CN111846308B - Liquid medicine filling method - Google Patents
Liquid medicine filling method Download PDFInfo
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- CN111846308B CN111846308B CN202010780256.4A CN202010780256A CN111846308B CN 111846308 B CN111846308 B CN 111846308B CN 202010780256 A CN202010780256 A CN 202010780256A CN 111846308 B CN111846308 B CN 111846308B
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- filling
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/003—Filling medical containers such as ampoules, vials, syringes or the like
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
- B65B3/10—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material
- B65B3/12—Methods of, or means for, filling the material into the containers or receptacles by application of pressure to material mechanically, e.g. by pistons or pumps
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/26—Methods or devices for controlling the quantity of the material fed or filled
- B65B3/28—Methods or devices for controlling the quantity of the material fed or filled by weighing
Abstract
The invention discloses a liquid medicine filling method, which is carried out by adopting a liquid medicine filling device, wherein the liquid medicine filling device comprises a weighing station and a liquid separation container, the bottom of the liquid separation container is obliquely arranged and is provided with a plurality of liquid outlets along the length direction, a plurality of filling needles which are arranged side by side are arranged above the weighing station, each liquid outlet is connected with each filling needle through a pipeline, each pipeline is provided with a filling pump, and the filling method comprises the following steps: and quantitatively filling the medicine bottles on a weighing station, weighing and replenishing liquid so as to enable the dosage of each medicine bottle to reach the standard. The liquid medicine filling method has the advantages of improving the production efficiency, reducing the waste amount of liquid medicine and the like.
Description
Technical Field
The invention relates to the technical field of food and medicine packaging mechanical equipment, in particular to a liquid medicine filling method.
Background
The existing liquid medicine filling device comprises a filling needle, a filling station, a front weighing station and a rear weighing station, wherein the front weighing station is used for weighing empty bottles before the filling station, the rear weighing station is used for weighing total bottles filled with liquid medicine after the filling station, and the filling needle is fixedly arranged above the filling station, so that a liquid supplementing mechanism is required to be arranged on a subsequent station of the filling station, and liquid is supplemented to bottles which do not have the liquid injection up to the standard. Moreover, the existing fluid infusion mechanism has low fluid infusion efficiency and is difficult to fill the requirement of high-efficiency fluid infusion. Moreover, when the traditional liquid medicine filling device is used for filling liquid medicine, the waste amount of the liquid medicine is large. Meanwhile, the filling amount of liquid medicine filling needs to be strictly controlled, especially in the initial stage of medicine filling, air exists in a pipeline of a filling device, accurate quantitative filling is difficult during filling, medicine bottles are metered after filling, and if the filling amount standard is not met, the medicine bottles need to be rejected, so that medicine waste is caused. And at a batch liquid medicine filling process end stage, because total liquid medicine volume is not enough, when filling liquid medicine to a plurality of medicine bottles, hardly guarantee that the dress volume of filling in the medicine bottle is qualified, also must reject the unqualified medicine bottle of liquid medicine filling volume, lead to the medicine waste once more.
The filling system generally adopts a manual intervention mode to process in the emptying and tail liquid filling stages of the production preparation stage, and has low efficiency, large pollution risk and more liquid medicine residues. According to different filling specifications and filling head numbers, the general residual quantity is different from 500ml to 2000 ml. If the residual liquid medicine is well utilized, according to the medicine bottle loading amount of 2ml specification, about 500-1000 bottles of qualified products can be produced in one batch, according to the market value of 100 yuan/piece, 5-10 ten thousand products can be produced in one batch, and according to 100 batches in one year, 1000 ten thousand products with market value of 500-1000 ten thousand can be produced. For biological drugs and innovative drugs with high added values, the economic benefit generated by the method is huge.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a liquid medicine filling method which can improve the production efficiency and reduce the waste amount of liquid medicine.
In order to solve the technical problems, the invention adopts the following technical scheme:
the liquid medicine filling method is carried out by adopting a liquid medicine filling device, the liquid medicine filling device comprises a weighing station and a liquid separating container, the bottom of the liquid separating container is obliquely arranged and is provided with a plurality of liquid outlets along the length direction, a plurality of filling needles which are arranged side by side are arranged above the weighing station, each liquid outlet and each filling needle are respectively connected through a pipeline, each pipeline is provided with a filling pump, and the filling method comprises the following steps: and quantitatively filling the medicine bottles on a weighing station, weighing and replenishing liquid so as to enable the dosage of each medicine bottle to reach the standard.
As a further improvement of the above technical solution:
the filling method further comprises the following steps: weighing at a weighing station, synchronously filling, and filling the medicine bottles with unqualified filling amount with the liquid medicine by a low-level filling needle.
The synchronous filling is that all filling needles are filled simultaneously and are weighed while filling.
The filling method further comprises the following steps: and weighing at a weighing station, filling one by one, and filling the medicine bottles with unqualified filling amount with the liquid by a low-level filling needle which is connected with a low-level liquid outlet on the liquid separation container.
The filling one by one is that among the adjacent filling needles, a high-position filling needle is filled firstly, and a low-position filling needle is replenished with liquid, and the high-position filling needle is connected with a high-position liquid outlet on the liquid separating container.
And filling the rest of the liquid medicine in the liquid separating container by adopting a lowest filling needle, wherein the lowest filling needle is a filling needle connected with a liquid outlet at the lowest position on the liquid separating container.
And filling the medicine liquid into the medicine bottles with the unqualified filling amount from the lowest filling needle.
The liquid medicine filling device is characterized by further comprising a medicine supply device, a liquid inlet valve and a buffer tank, wherein the medicine supply device is connected with the buffer tank through a liquid inlet pipeline, the liquid inlet pipeline is provided with the liquid inlet valve, and the buffer tank is connected with the liquid separating container through a connecting pipeline.
The top of the liquid separation container is provided with a liquid inlet, and the buffer tank is connected with the liquid inlet of the liquid separation container through a connecting pipeline.
The inclination angle of the liquid separation container is a, and a is more than 0 degree and less than or equal to 10 degrees.
Compared with the prior art, the invention has the advantages that:
the liquid medicine filling method is carried out by adopting a liquid medicine filling device, the liquid medicine filling device comprises a weighing station and a liquid separating container, the bottom of the liquid separating container is obliquely arranged and is provided with a plurality of liquid outlets along the length direction, a plurality of filling needles which are arranged side by side are arranged above the weighing station, each liquid outlet is connected with each filling needle through a pipeline, each pipeline is provided with a filling pump, and the filling method comprises the following steps: and quantitatively filling the medicine bottles on a weighing station, weighing and replenishing liquid so as to enable the dosage of each medicine bottle to reach the standard. For example, tail liquid filling is carried out on a weighing station, and each filling needle can be used for quantitative filling and filling, so that the liquid filling efficiency is improved; and for another example, normal filling production is carried out on the weighing station, and filling and supplementing are carried out on the weighing station, so that the production efficiency is improved.
Drawings
Fig. 1 is a schematic structural view of the liquid medicine filling apparatus of the present invention.
Fig. 2 is a comparison diagram of the liquid medicine filling method of the present invention when the tail liquid is filled.
Fig. 3 is a schematic structural view of a liquid separation container of the chemical filling apparatus of the present invention.
The reference numerals in the figures denote:
1. a weighing station; 4. a liquid separation container; 41. a liquid outlet; 42. a liquid inlet; 5. filling a needle; 6. a pipeline; 61. a filling pump; 7. a drug delivery device; 8. a liquid inlet valve; 9. and a buffer tank.
Detailed Description
The invention will be described in further detail below with reference to the drawings and specific examples.
Fig. 1 to 3 show an embodiment of the liquid medicine filling method of the present invention, which is performed by using a liquid medicine filling device, the liquid medicine filling device includes a weighing station 1 and a liquid separation container 4, the bottom of the liquid separation container 4 is obliquely arranged and provided with a plurality of liquid outlets 41 along a length direction, a plurality of filling needles 5 arranged side by side are arranged above the weighing station 1, each liquid outlet 41 and each filling needle 5 are respectively connected by a pipeline 6, each pipeline 6 is provided with a filling pump 61, and the filling method includes: and (3) quantitatively filling the medicine bottles on a weighing station 1, weighing and replenishing liquid, so that the dosage of each medicine bottle reaches the standard. For example, the tail liquid filling is carried out on the weighing station 1, and each filling needle 5 can be used for quantitative filling and filling, so that the liquid filling efficiency is improved; for another example, normal filling production is carried out on the weighing station 1, and filling and supplementing are carried out on the weighing station 1, so that the production efficiency is improved.
In this embodiment, the filling method further includes: weighing is carried out on the weighing station 1, synchronous filling is carried out, and the medicine bottles with unqualified filling quantity are filled with liquid medicine by the low-level filling needle 5. The synchronous filling is that all filling needles 5 are filled simultaneously and are weighed while filling. If the tail liquid in the liquid separation container 4 is filled, the filling needles 5 are filled synchronously, and then the medicine bottles which do not reach the standard are filled by the lower filling needles 5, so that the tail liquid filling efficiency is improved, and the waste amount of the medicine liquid is reduced.
In this embodiment, the filling method further includes: and weighing the bottles at the weighing station 1, filling the bottles one by one, and filling the bottles with unqualified filling amount with the liquid medicine by using a low-level filling needle 5, wherein the low-level filling needle 5 is a filling needle 5 connected with a low-level liquid outlet 41 on the liquid separation container 4. The filling is carried out one by one, wherein in the adjacent filling needles 5, the high-position filling needle 5 is filled firstly, the low-position filling needle 5 is replenished with liquid, and the high-position filling needle 5 is the filling needle 5 connected with the high-position liquid outlet 41 on the liquid separation container 4. Specifically, among the adjacent filling needles 5, the front filling needle 5 is connected with the low-position liquid outlet 41 on the liquid separation container 4, the rear filling needle 5 is connected with the high-position liquid outlet 41 on the liquid separation container 4, and the filling needles 5 are filled one by one from back to front until no liquid medicine flows out of the filling needles 5, so that the waste amount of the liquid medicine is further reduced.
In this embodiment, the remaining liquid medicine in the liquid separation container 4 is filled by the lowest filling needle 5, and the lowest filling needle 5 is the filling needle 5 connected to the lowest liquid outlet 41 of the liquid separation container 4, so that the moving frequency of the medicine bottle is reduced, and the filling efficiency of the tail liquid is further improved.
In this embodiment, the medicine liquid is replenished to the medicine bottle with the substandard filling amount through the lowest filling needle 5. Specifically, on station 1 weighs, only adopt the extreme lower position to irritate 5 fluid infusion of needle, other irritate 5 normal filling of needle, until there is no liquid medicine outflow, the needle 5 fluid infusion is all irritated through the extreme lower position to the medicine bottle that does not reach standard to, reduced the removal number of times of medicine bottle, made the operation simpler, improved work efficiency.
The method comprises the following specific steps:
s1: as shown in fig. 1, in the preparation stage, a weighing station 1 pre-weighs an empty bottle, then each filling pump 61 is opened to carry out quantitative filling and emptying, and then liquid is replenished while weighing until the dosage of each medicine bottle reaches the standard; (8 bottles at a time, quantitative irrigation + supplement irrigation)
S2: as shown in fig. 1, normal quantitative filling production; (Once 8 bottles, quantitative filling)
S3: as shown in fig. 2, the tail liquid is filled by bottle, that is, of the adjacent filling needles 5, the filling needle 5 connected with the higher-level liquid outlet 41 of the liquid separation container 4 is filled first, and then the filling needle 5 connected with the lower-level liquid outlet 41 of the liquid separation container 4 is replenished. (one bottle at a time, 80% quantitative filling, A8 No. filling needle 5 is filled completely, then A7 No. filling needle 5 is filled, finally, A1 No. filling needle 5 is not qualified, stop production)
The filling prepares the stage earlier stage, carries out the exhaust to the air in the pipeline, and because of receiving the influence of air in the pipeline this moment, the medicine bottle filling volume is not up to standard, through the limit liquid infusion of weighing limit to make the medicine bottle internal loading volume qualified, can not cause the medicine extravagant. When the dosage of the liquid separation container 4 is insufficient, the high-position filling needles 5 are filled in a fixed quantity, and the low-position filling needles 5 are filled one by one, so that tail liquid (residual liquid medicine) is effectively utilized, and the unqualified filling of at most one bottle of liquid medicine is ensured.
In this embodiment, liquid medicine filling device is still including supplying medicine device 7, feed liquor valve 8 and buffer tank 9, supplies medicine device 7 and buffer tank 9 to pass through the feed liquor pipe connection, is equipped with feed liquor valve 8 on the feed liquor pipe, and buffer tank 9 passes through the connecting tube with dividing liquid container 4 and is connected. The top of the liquid separating container 4 is provided with a liquid inlet 42, and the buffer tank 9 is connected with the liquid inlet 42 of the liquid separating container 4 through a connecting pipeline. The inclined angle of the liquid separation container 4 is a, and a is more than 0 degree and less than or equal to 10 degrees.
The liquid medicine filling device comprises the following specific filling steps:
filling and emptying (for example, the number of filling needles 5 is 8, the number of scales at the weighing station 1 is 8, each filling needle 5 is marked with the numbers A1-A8 from front to back along the conveying direction F of the medicine bottle, each scale is marked with the numbers B1-B8 from front to back, each filling needle 5 is respectively aligned with each scale at the weighing station 1)
a) The buffer tank 9 intermittently feeds liquid into the liquid separation container 4 to realize bubble-free filling in the liquid separation container 4;
b) the medicine bottles are weighed forwards, the number of the medicine bottles in a single bottle walking is 8, and 3 groups of the medicine bottles are continuously fed onto a weighing station 1 (according to the period of a sector block);
c) when the medicine bottle reaches the upper part of the scale, the filling needle 5 is inserted into the bottle mouth;
d) using a side irrigation side scale to respectively empty each pipeline;
e) after single emptying, the bottle is continuously moved to finish the subsequent two groups of filling;
f) and finishing emptying and entering a loading calibration mode. (if quantitative filling exists, the filling amount calibration is carried out, and if no quantitative filling is carried out, the filling amount calibration is not carried out when the filling and weighing are carried out simultaneously);
second, load calibration
a) Continuously feeding 8 bottles in a single bottle feeding number;
b) after the whole group of 8 medicine bottles reaches the upper part of each scale, each filling needle 5 is inserted into the bottle mouth (the whole group of 8 medicine bottles is marked with the labels of C1-C8 from front to back);
c) respectively acquiring the empty bottle weight of each medicine bottle by 8 scales, and carrying out single filling according to the target filling amount;
d) acquiring the total filled weight, and calculating the net filled weight of each filling pump 61;
e) caching the net weight value of single filling for judging whether to carry out loading calibration or not;
f) judging whether the filling quantity of each bottle is qualified, and if so, continuing filling the next group of medicine bottles; if not, skipping to the step c, wherein the target filling amount is the deviation value obtained in the previous round of the medicine bottle;
g) continuously judging the net weight value of single filling of 2 groups of medicine bottles, and comparing the deviation values internally to satisfy the following conditions within a certain range (for example: the internal deviation is within 1 percent), and calculating the average value for calibration;
h) and (5) continuing filling until each filling needle 5 is qualified after single filling, and performing normal filling production.
Third, filling the tail liquid (first method)
a) Filling tail liquid when the weighing sensor of the buffer tank 9 detects the low liquid level of the liquid medicine in the buffer tank 9;
b) the number of bottles in a single bottle walking is 1, and the bottles are continuously fed until the medicine bottles reach a scale No. B8 on a weighing station 1;
c) acquiring the tare weight of the medicine bottle, filling once according to the target filling amount, and acquiring the total weight after filling;
d) calculating a deviation value and judging whether the loading is qualified or not;
e) if the quality is qualified, finishing the filling of the single bottle, and moving the bottle to continue the filling of the next bottle; if not, skipping to the step c to continue filling, wherein the target filling amount is the deviation value calculated last time;
f) continuing filling until the single bottle is qualified, and if the single bottle is not qualified after being filled for more than n times (n is 3, 4 and 5 … …, and n can be set), ending the filling of the A8 number filling needle 5 and moving the bottle forwards;
g) completing liquid supplement by an A7 filling needle 5 until the filling quantity is qualified;
h) continuously moving the bottle, and filling with an A7 filling needle 5;
j) and repeating the flow of the steps c to h until the filling of the filling needle No. A1 is finished.
Fourth, filling the tail liquid (second method)
a) Filling tail liquid when the weighing sensor of the buffer tank 9 detects the low liquid level of the liquid medicine in the buffer tank 9;
b) the number of bottles is 1 in a single-time bottle walking, and the bottles are continuously fed until the medicine bottles reach a weighing station 1 on a scale from B2 to B8;
c) filling the medicine bottles of No. B2-B8 once after the tare weight of the medicine bottles is obtained, and continuing to move the bottles singly;
d) deviation values of the medicine bottles of No. B2-B8 are obtained one by one on a scale of No. B1, and liquid is replenished one by one;
e) after finishing the group of medicine bottles, continuously weighing the tare weight of the next medicine bottle No. B2-B8, filling and moving the medicine bottles individually;
f) if the filling amount of a certain filling pump 61 is lower than 20% in a single medicine bottle, stopping the corresponding filling of the filling pump 61 and directly rejecting waste;
g) and finally, only feeding the No. 2 medicine bottle, and stopping production when the filling pump 61 connected with the No. A1 filling needle 5 runs for more than 30s and the filling amount still does not reach the target filling amount, and finishing the whole process.
Although the present invention has been described with reference to the preferred embodiments, it is not intended to be limited thereto. Those skilled in the art can make numerous possible variations and modifications to the present invention, or modify equivalent embodiments to equivalent variations, without departing from the scope of the invention, using the teachings disclosed above. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical spirit of the present invention should fall within the protection scope of the technical scheme of the present invention, unless the technical spirit of the present invention departs from the content of the technical scheme of the present invention.
Claims (8)
1. A liquid medicine filling method is characterized in that: adopt liquid medicine filling device to go on, liquid medicine filling device is including weighing station (1) and branch liquid container (4), divide liquid container (4) bottom slope to set up and be equipped with a plurality of liquid outlets (41) along length direction, weigh station (1) top and be equipped with a plurality of needles (5) of irritating of arranging side by side, each liquid outlet (41) and each irritate needle (5) and be connected through pipeline (6) respectively, each all be equipped with filling pump (61) on pipeline (6), the filling method includes: quantitatively filling the medicine bottles on a weighing station (1), and weighing and replenishing liquid to ensure that the dosage in each medicine bottle reaches the standard; the liquid medicine bottle filling machine is characterized in that weighing is carried out on a weighing station (1), filling is carried out one by one, medicine bottles with unqualified filling amount are filled with medicine liquid by a low-position filling needle (5), the low-position filling needle (5) is a filling needle (5) connected with a low-position liquid outlet (41) on a liquid separating container (4), filling is carried out one by one, in the adjacent filling needles (5), the high-position filling needle (5) is filled firstly, the low-position filling needle (5) is filled with liquid again, and the high-position filling needle (5) is a filling needle (5) connected with the high-position liquid outlet (41) on the liquid separating container (4).
2. The medical liquid filling method according to claim 1, wherein: the filling method further comprises the following steps: weighing is carried out on the weighing station (1), synchronous filling is carried out, and the medicine liquid is filled into the medicine bottles with the unqualified filling quantity through the low-level filling needle (5).
3. The medical liquid filling method according to claim 2, wherein: the synchronous filling is that all filling needles (5) are filled simultaneously and are weighed while filling.
4. The medical liquid filling method according to claim 1, wherein: and the rest part of the liquid medicine in the liquid separating container (4) is filled by adopting a lowest filling needle (5), and the lowest filling needle (5) is the filling needle (5) connected with a lowest liquid outlet (41) on the liquid separating container (4).
5. The medical liquid filling method according to claim 1, wherein: the medicine liquid is filled in the medicine bottle with the filling quantity not reaching the standard through the lowest filling needle (5).
6. The liquid medicine filling method according to any one of claims 1 to 5, wherein: liquid medicine filling device is still including supplying medicine device (7), feed liquor valve (8) and buffer tank (9), supply medicine device (7) and buffer tank (9) to pass through the feed liquor pipe connection, be equipped with feed liquor valve (8) on the feed liquor pipe way, buffer tank (9) are connected through connecting tube with dividing liquid container (4).
7. The medical liquid filling method according to claim 6, wherein: the top of the liquid separating container (4) is provided with a liquid inlet (42), and the buffer tank (9) is connected with the liquid inlet (42) of the liquid separating container (4) through a connecting pipeline.
8. The liquid medicine filling method according to any one of claims 1 to 5, wherein: the inclination angle of the liquid separation container (4) is a, and a is more than 0 degree and less than or equal to 10 degrees.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010780256.4A CN111846308B (en) | 2020-08-05 | 2020-08-05 | Liquid medicine filling method |
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| CN202010780256.4A CN111846308B (en) | 2020-08-05 | 2020-08-05 | Liquid medicine filling method |
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| CN111846308B true CN111846308B (en) | 2022-02-22 |
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| CN111792065B (en) * | 2020-08-05 | 2021-09-24 | 楚天科技股份有限公司 | Filling method for reducing liquid medicine loss |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| IT1321270B1 (en) * | 2000-05-19 | 2004-01-08 | Ima Spa | DOSING UNIT. |
| CN202508290U (en) * | 2012-04-20 | 2012-10-31 | 常德市汇美食品有限公司 | Filling weighing device |
| DE102012208060A1 (en) * | 2012-05-14 | 2013-11-14 | Robert Bosch Gmbh | Filling machine for filling of containers with liquid e.g. medicinal substance, has handling device arranged out of containers or cavity of containers and out of weighing apparatus, to withdraw container cavity from weighing apparatus |
| CN202879860U (en) * | 2012-10-29 | 2013-04-17 | 中国石油化工股份有限公司 | Weighting type filling equipment calculating on line statistical process control (SPC) controlling system |
| DE102017207307A1 (en) * | 2017-03-13 | 2018-09-13 | Bausch + Ströbel Maschinenfabrik Ilshofen GmbH + Co. KG | System with alternating filling of containers and method for this |
| CN110077638A (en) * | 2019-04-30 | 2019-08-02 | 楚天科技股份有限公司 | A kind of medical fluid automatic filling control system, bulking system and control method |
| CN210653719U (en) * | 2019-08-09 | 2020-06-02 | 江苏金旺智能科技有限公司 | Feed supplement device and material bagging equipment |
| CN210528431U (en) * | 2019-09-10 | 2020-05-15 | 楚天科技股份有限公司 | Filling system |
| CN111483631A (en) * | 2020-05-19 | 2020-08-04 | 楚天科技股份有限公司 | Filling system and filling method |
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