WO2022022464A8 - 新型双特异性抗cd3/cd20多肽复合物配制剂 - Google Patents

新型双特异性抗cd3/cd20多肽复合物配制剂 Download PDF

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WO2022022464A8
WO2022022464A8 PCT/CN2021/108455 CN2021108455W WO2022022464A8 WO 2022022464 A8 WO2022022464 A8 WO 2022022464A8 CN 2021108455 W CN2021108455 W CN 2021108455W WO 2022022464 A8 WO2022022464 A8 WO 2022022464A8
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formulation
polypeptide complex
bispecific anti
novel bispecific
antigen
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PCT/CN2021/108455
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English (en)
French (fr)
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WO2022022464A1 (zh
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朱友伟
李盈淳
程艳菊
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正大天晴药业集团股份有限公司
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Priority to CN202180041422.1A priority Critical patent/CN115715200A/zh
Priority to EP21849910.1A priority patent/EP4190352A1/en
Priority to CA3217391A priority patent/CA3217391A1/en
Priority to US18/007,012 priority patent/US20230279138A1/en
Publication of WO2022022464A1 publication Critical patent/WO2022022464A1/zh
Publication of WO2022022464A8 publication Critical patent/WO2022022464A8/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
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  • Mycology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

本发明提供一种含有第一抗原结合部分和第二抗原结合部分的新型双特异性抗CD3/CD20多肽复合物配制剂，具体而言，其包括液体配制剂和冻干配制剂。
PCT/CN2021/108455 2020-07-27 2021-07-26 新型双特异性抗cd3/cd20多肽复合物配制剂 WO2022022464A1 (zh)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN202180041422.1A CN115715200A (zh) 2020-07-27 2021-07-26 新型双特异性抗cd3/cd20多肽复合物配制剂
EP21849910.1A EP4190352A1 (en) 2020-07-27 2021-07-26 Formulation of novel bispecific anti-cd3/cd20 polypeptide complex
CA3217391A CA3217391A1 (en) 2020-07-27 2021-07-26 Formulation of novel bispecific anti-cd3/cd20 polypeptide complex
US18/007,012 US20230279138A1 (en) 2020-07-27 2021-07-26 Novel bispecific anti-cd3/cd20 polypeptide complex formulation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN202010733597 2020-07-27
CN202010733597.6 2020-07-27

Publications (2)

Publication Number Publication Date
WO2022022464A1 WO2022022464A1 (zh) 2022-02-03
WO2022022464A8 true WO2022022464A8 (zh) 2022-03-03

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ID=80037593

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PCT/CN2021/108455 WO2022022464A1 (zh) 2020-07-27 2021-07-26 新型双特异性抗cd3/cd20多肽复合物配制剂

Country Status (5)

Country Link
US (1) US20230279138A1 (zh)
EP (1) EP4190352A1 (zh)
CN (1) CN115715200A (zh)
CA (1) CA3217391A1 (zh)
WO (1) WO2022022464A1 (zh)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011007589A (es) 2009-01-16 2011-08-17 Glaxosmithkline Llc Tratamiento de un cancer usando una combinacion de bendamustine y un anticuerpo anti-cd20.
US20140004037A1 (en) 2012-01-19 2014-01-02 Therapeutic Proteins, Inc. Stabilization of the anti-cd20 antibody rituximab
TWI701042B (zh) 2014-03-19 2020-08-11 美商再生元醫藥公司 用於腫瘤治療之方法及抗體組成物
CA3074130A1 (en) * 2017-09-21 2019-03-28 WuXi Biologics Ireland Limited Novel anti-cd3epsilon antibodies
JP7337079B2 (ja) * 2018-02-15 2023-09-01 マクロジェニクス，インコーポレーテッド 変異型ｃｄ３結合ドメイン、及び疾患の治療のための併用療法におけるその使用
WO2019228406A1 (en) * 2018-05-29 2019-12-05 Wuxi Biologics (Shanghai) Co., Ltd. A novel anti-cd3/anti-cd20 bispecific antibody
WO2020084608A1 (en) * 2018-10-22 2020-04-30 Explore Bio 1 Ltd Precursor bispecific antibody constructs and methods of use thereof
CA3118397A1 (en) * 2018-11-01 2020-05-07 Shandong Newtime Pharmaceutical Co., Ltd. Bispecific antibody targeting cd3 and bcma, and uses thereof

Also Published As

Publication number Publication date
US20230279138A1 (en) 2023-09-07
CA3217391A1 (en) 2022-02-03
EP4190352A1 (en) 2023-06-07
CN115715200A (zh) 2023-02-24
WO2022022464A1 (zh) 2022-02-03

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