WO2022008480A1 - Dispositif d'administration de médicament - Google Patents

Dispositif d'administration de médicament Download PDF

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Publication number
WO2022008480A1
WO2022008480A1 PCT/EP2021/068587 EP2021068587W WO2022008480A1 WO 2022008480 A1 WO2022008480 A1 WO 2022008480A1 EP 2021068587 W EP2021068587 W EP 2021068587W WO 2022008480 A1 WO2022008480 A1 WO 2022008480A1
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WO
WIPO (PCT)
Prior art keywords
plunger rod
drug delivery
delivery device
tapered portion
cavity
Prior art date
Application number
PCT/EP2021/068587
Other languages
English (en)
Inventor
Adrien Plouvier
Marc FLIPPE
Original Assignee
Becton Dickinson France
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson France filed Critical Becton Dickinson France
Publication of WO2022008480A1 publication Critical patent/WO2022008480A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1458—Means for capture of the plunger flange
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M5/1456—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic

Definitions

  • the present disclosure relates generally to a drug delivery device and, more particularly, to an auto-injector.
  • Various types of automatic injection devices e.g., auto-injectors
  • drug solutions and other liquid therapeutic preparations e.g., medicaments
  • these injection devices include a reservoir that is pre-filled with the medicaments, and some type of automatic needle- injection mechanism that can be triggered by the user.
  • injection devices are designed so that the reservoir, such as a pre-filled syringe, is disposed in the device during assembly thereof.
  • the pre-filled syringe is provided with a stopper in a syringe barrel.
  • the stopper is capable of being moved within the barrel so as to expel the medicament to be injected.
  • a plunger which is uncoupled from (e.g., disengaged with) the stopper in an initial locked configuration of the injection device and coupled to an actuation device, is moved by the actuation device upon triggering of the injection device by the user. In a released position, the plunger subsequently contacts the stopper to displace the stopper and dispense medicament from the injection device.
  • One objective of the present disclosure is to provide a drug delivery device that prevents total or partial failure of the device as a result of improper contact between the stopper and the plunger rod.
  • Another objective of the present disclosure is to provide a drug delivery device that prevents total or partial failure of the device as a result of improper contact between the plunger rod and the actuation device.
  • the invention proposes a drug delivery device comprising: a drive assembly configured to displace a plunger rod within a barrel, the drive assembly comprising an actuation body moveable between a locked position in which displacement of the drive assembly is prevented and a released position in which displacement of the drive assembly in a proximal direction is permitted, the actuation body comprising an engagement surface configured to contact a distal end of the plunger rod, the engagement surface having a centering portion configured to guide engagement of the distal end of the plunger rod with the engagement surface of the actuation body to align a longitudinal axis of the plunger rod to be parallel to an axis of displacement along which the actuation body moves upon displacement of the drive assembly from the locked position to the released position.
  • the engagement surface of the actuation body comprises a proximal surface and a cavity distally recessed relative to the proximal surface
  • the cavity comprises the centering portion, and the centering portion comprising a tapered portion such that the cavity increases in lateral dimension in the proximal direction,
  • the cavity increases gradually in the lateral dimension in the proximal direction along the tapered portion
  • the cavity is configured to receive the distal end of the plunger rod therein
  • the engagement surface comprises a distal planar surface and a protrusion extending axially and proximally beyond the planar surface, the protrusion comprising the centering portion
  • the centering portion of the protrusion comprises a first tapered portion and a second tapered portion, the second tapered portion having a greater lateral dimension than the first tapered portion, the first tapered portion located in front of the second tapered portion in the proximal direction
  • the first and second tapered portion of the protrusion decrease gradually in the lateral dimension in the proximal direction
  • the drug delivery device further comprises a syringe assembly, the syringe assembly comprising a barrel, a stopper disposed in the barrel, and the plunger rod, the distal end of the plunger rod coupled to the stopper, [0017] the distal end of the plunger rod comprises a flanged portion, the flanged portion configured to be received in the cavity of the actuation body,
  • a lateral dimension of the cavity is greater than or equal to a lateral dimension of the distal end of the plunger rod
  • the distal end of the plunger rod comprises a cavity, the cavity configured to receive the protrusion of the actuation body therein,
  • the cavity comprises a first tapered portion and a second tapered portion, and a lateral dimension of the cavity decreases in the proximal direction along the first and second tapered portions,
  • the first tapered portion is located in front of the second tapered portion in the proximal direction, and wherein a minimum lateral dimension of the cavity along the first tapered portion is less than a minimum lateral dimension of the cavity along the second tapered portion, [0022] the engagement surface is spaced apart from the distal end of the plunger rod in the locked position,
  • the drug delivery device further comprises a housing in which the drive assembly and the syringe assembly are disposed, and
  • the drive assembly further comprises a biasing member operatively coupled to the actuation body to displace the actuation body relative to the housing along the axis of displacement.
  • FIG. 1 is a perspective view of a drug delivery device
  • FIGS. 2A and 2B are cross-sectional views of the drug delivery device according to one embodiment.
  • FIGS. 3A and 3B are cross-sectional views of the drug delivery device according to another embodiment.
  • spatially relative terms such as “beneath,” “below,” “lower,” “bottom,” “above,” “over,” “upper,” “top,” “front,” “rear,” “left,” “right,” and the like, may be used for ease of description to describe one element's or feature's relationship to another element(s) or feature(s) as illustrated in the figures. Unless otherwise specified, the spatially relative terms are intended to encompass different orientations of the devices in addition to the orientation depicted in the figures.
  • proximal refers to a location, such as a proximal end, that is nearer to a point of reference such as a point of contact on a patient.
  • distal refers to a location, such as a distal end, that is farther from a point of reference such as a point of contact on a patient.
  • proximal and distal refer to, for example, directions nearer to and farther from, respectively a patient’s body against which a portion of the drug delivery device, such as at a proximal end thereof, may be disposed in use.
  • axial As used herein, the terms “axial,” “axially,” “longitudinal,” and “longitudinally” generally mean and refer to a direction along or parallel to a longitudinal axis of an element(s) of the drug delivery device described herein.
  • radial generally mean and refer to a direction perpendicular to the central, longitudinal axis of the elements) of the drug delivery device described herein.
  • the term “configured” refers to a size, shape, material composition, material distribution, orientation, and arrangement of one or more of at least one structure and at least one apparatus facilitating operation of one or more of the structure and the apparatus in a pre determined way.
  • FIG. 1 illustrates a perspective view of a drug delivery device 100 according to embodiments of the present disclosure.
  • FIGS. 2A and 3A illustrate cross-sectional views of the drug delivery device 100.
  • the drug delivery device 100 may comprise a first subassembly 102, a second subassembly 104, and a syringe assembly 120.
  • the first subassembly 102 may comprise a cap 106 having an outer portion 108, a needle cover 110, a syringe holder 112, a cassette body 114, and a lower housing shell 116.
  • the second subassembly 104 may comprise a drive assembly 140, a motor body 142, a lever actuation member 144, and an upper housing shell 146.
  • the lower housing shell 116, the cassette body 114, and the upper housing shell 146 collectively form a housing 101.
  • the housing 101 may be configured to receive and enclose a plurality of the components of the drug delivery device 100 therein.
  • the upper housing shell 146 has been removed in the views of FIGS.
  • the first subassembly 102 and the second subassembly 104 may be coupled together during assembly of the drug delivery device 100 by a locking clip.
  • the syringe assembly 120 may comprise a barrel 122, a stopper 124, a cannula 134 (e.g., needle), a rigid needle shield (RNS) 136, and a plunger rod 126.
  • the barrel 122 may be disposed in the syringe holder 112.
  • the stopper 124 may be disposed in the barrel 122.
  • the plunger rod 126 extends along a longitudinal axis 132 between a distal end 128 and a proximal end 130.
  • the distal end 128 of the plunger rod 126 may comprise a flanged portion 129.
  • the distal end 129 of the plunger rod 126 may comprise a planar surface.
  • the proximal end 130 of the plunger rod 126 may be disposed in the barrel 122.
  • the proximal end 130 of the plunger rod 126 may be coupled to the stopper 124.
  • the plunger rod 126 may be coupled to the stopper 124 by a threaded connection.
  • the present disclosure is not so limited and the plunger rod 126 may be coupled to the stopper 124 by other mechanical connections and/or by a non-mechanical connections, such as by adhesives.
  • the drive assembly 140 may comprise an actuation body 148.
  • the actuation body 148 may be moveable between a locked position in which displacement of the drive assembly 140 is prevented and a released position in which displacement of the drive assembly 140 in a proximal direction is permitted.
  • the proximal direction is indicated by the arrow 153 in FIGS. 2 A and 3 A.
  • the drive assembly 140 may further comprise a drive member 156 and a drive guide member 157.
  • the drive member 156 may be a biasing element such as a compression spring.
  • the drive member 156 may be, but is not limited to, compressed gas, an electric motor, hydraulic pressure, and other types of springs.
  • the drive member 156 is restricted to movement within the drive guide member 157 may be received within a drive opening defined by the actuation body 148.
  • the drive member 156 engages the actuation body 148 and the motor body 142 and biases the actuation body 148 in the proximal direction 153.
  • the lever actuation member 144 is moveable (e.g., rotatable) between a locked position and a released position.
  • the lever actuation member 144 is engaged with the motor body 142 to prevent movement of the drive assembly 140 in the proximal direction toward the syringe assembly 120.
  • the lever actuation member 144 is rotated into the released position, the lever actuation member 144 is disengaged with the motor body 142 allowing movement of the drive assembly 40 in the proximal direction toward the syringe assembly 120.
  • the drive assembly 140 may be configured to engage and displace the syringe assembly 120 such that the cannula 134 pierces the skin of the patient and the stopper 124 is displaced with the plunger rod 126 so as to deliver medicament from within the barrel 122, through the cannula 134, and into the patient.
  • the drug delivery device 100 is shown in the locked position.
  • the distal end 128 of the plunger rod 126 may be spaced apart from the actuation body 148.
  • the drive assembly 140 may be configured to automatically delivery a dose of medicament from the syringe assembly 120 to a patient. More particularly, upon actuation of the drug delivery device 100, the actuation body 148 of the drive assembly 140 contacts the distal end 128 of the plunger rod 126 to displace the plunger rod 126 and the stopper 124 within the barrel 122.
  • the actuation body 148 may also include an audio indicator member 149.
  • the audio indicator member 149 may be configured to provide an audible indication to a user when the device 100 transitions from the locked to the release position.
  • the audio indicator member 149 may engage with one or more ribs 151 of the cassette body 114 when the device 100 may be in the released position, thereby deflecting the audio indicator member 149. Subsequently, the audio indicator member 149 disengages the ribs 151 of the cassette body 114 and contacts the lower housing shell 116 to provide an audible click.
  • the drive assembly 140 may be actuated by movement of the needle cover 110. Movement of the needle cover 100 causes the lever actuation member 144 to rotate to the released position thereby releasing or allowing the drive assembly 140 to move into engagement with the stopper 124 and dispense medicament from the barrel 122.
  • the actuation body 148 may comprise an engagement surface 150 configured to contact the distal end 128 of the plunger rod 126. As previously discussed, in the locked position, the plunger rod 126 and the actuation body 148 are spaced apart from each other. In other words, the plunger rod 126 may be disengaged from the actuation body 148 such that the engagement surface 150 does not contact the distal end 128 of the plunger rod 126 in the locked position. [0052] A distance by which the distal end 128 of the plunger rod 126 and the engagement surface 150 are separated may be adjustable.
  • the stopper 124 and the plunger rod 126 coupled thereto may be disposed at various positions within the barrel 122 depending upon the volume of medicament disposed in the barrel 122.
  • the distance between the plunger rod 126 and the engagement surface 150 may be smaller when a relatively larger volume of medicament is disposed in the barrel 122 than when a relatively smaller volume of medicament in the barrel 122. The distance may also depend upon the length of the plunger rod 126 assembled within the barrel 122.
  • the plunger rod 126 When the syringe assembly 120 is assembled and ready for use by the patient, the plunger rod 126 may be inadvertently tilted within the barrel 122 or otherwise offset within the barrel 122. Put differently, the longitudinal axis 132 of the plunger rod 126 may be disposed at an angle relative to the axis of displacement 154 and/or the longitudinal axis 132 of the plunger rod 126 may not be coaxial with a longitudinal axis of the barrel 122.
  • the force of the actuation body 128 acting on the plunger rod 126 may cause the plunger rod 126 and the stopper 124 to be displaced toward an inner wall of the barrel 122 and/or may cause an interference between the plunger rod 126 and the barrel 122 that inhibits displacement of the plunger rod 126 within the barrel 122.
  • Such lateral displacement and/or interference may result in failure of the barrel 122, may prevent or limit displacement of the stopper 124 and plunger rod 126 within the barrel 122, and/or otherwise prevent proper functioning of the syringe assembly 120 such that the proper dosage of medicament is not dispensed from the drug delivery device 100.
  • the engagement surface 150 may be configured to align the longitudinal axis 132 of the plunger rod 126 to be parallel to the axis of displacement 154 along which the actuation body 148 moves.
  • the engagement surface 150 may be configured to align the longitudinal axis 132 of the plunger rod 126 to be coaxial with a longitudinal axis 131 extending central through the barrel 122 when the plunger rod 126 is engaged with the actuation body 148.
  • the engagement surface 150 may be a longitudinal axis 161 extending centrally through the cavity 162 such that the engagement surface 150 may be configured to align the longitudinal axis 132 of the plunger rod 126 to be coaxial with the longitudinal axis 161 of the cavity 162 when the plunger rod 126 is engaged with the actuation body 148.
  • FIGS. 2B and 3B Enlarged views of an interface between the plunger rod 126 and the actuation body 148 including the engagement surface 150 according to embodiments of the present disclosure are illustrated in FIGS. 2B and 3B.
  • the engagement surface 150 of the actuation body 148 may comprise a proximal surface 160 and a cavity 162 that is distally recessed relative to the proximal surface 160.
  • the proximal surface 160 may be a planar surface.
  • the cavity 162 may be configured to receive the distal end 128 of the plunger rod 126 therein. More particularly, the cavity 162 may be configured to receive the flanged portion 129 therein. In some embodiments, at least a portion of the cavity 162 may have a shape that is complementary to the shape of the flanged portion 129 of the plunger rod 126.
  • the cavity 162 may have a lateral dimension that is greater than a lateral dimension of the distal end 128 of the plunger rod 126.
  • the cavity 162 may comprise at least one centering portion 152.
  • the centering portion 152 of the cavity 162 is configured to center the distal end 128 of the plunger rod 126 therein.
  • the actuation body 148 is displaced along the axis of displacement 154 in the proximal direction 153, the distal end 128 of the plunger rod 126 initially contacts the centering portion 152 of the cavity 162.
  • the centering portion 152 guides the plunger rod 126 within the cavity 162.
  • the centering portion 152 acts on the plunger rod 126 to vary (e.g., reduce) the angle between the longitudinal axis 132 and the axis of displacement 154 so as to align the longitudinal axis 132 of the plunger rod 126 to be parallel to the axis of displacement 154.
  • the centering portion 152 may be a tapered portion.
  • the term “tapered” means and refers to a portion of the drug delivery device 100 that decreases gradually and/or intermittently in a given dimension in a given direction.
  • the tapered portion may decrease gradually in a given dimension such that the tapered portion is defined by a sloped (e.g., inclined) surface. Alternatively or additionally, the tapered portion may decrease intermittently such that the tapered portion is defined by a stepped surface.
  • the centering portion 152 increases in a lateral dimension (e.g., width) in the proximal direction 153 and, correspondingly, the lateral dimension diminishes (e.g. decreases) in a distal direction opposite the proximal direction 153.
  • the centering portion 152 may have a conical shape. Accordingly, the centering portion 152 may increase in diameter in the proximal direction 153 or decrease in diameter in the distal direction.
  • the cavity 162 may also comprise a receiving portion 163 that receives the flanged portion 129 of the plunger rod 126 therein.
  • the receiving portion 163 may be defined an untapered surface.
  • untapered means and refers to a portion of the drug delivery device 100 that is substantially constant in a given dimension in a given direction.
  • the centering portion 152 may be located in front of the receiving portion 163 in the proximal direction 153.
  • the lateral dimension (e.g., width) of centering portion 152 and the lateral dimension of the receiving portion 163 may be greater than or equal to a lateral dimension of the flanged portion 129 of the plunger rod 126.
  • the cavity 162 may be sized and configured to engage with any plunger rod known in the art without requiring modification to such plunger rods.
  • the distal end 128 of the plunger rod 126 may comprise a planar surface.
  • a base of the cavity 162 within the receiving portion 163 may comprise a planar surface.
  • the planar surface of the plunger rod 126 and the planar surface of the cavity 162 extend parallel to each other such that the planar surfaces may abut against each other when the distal end 128 of the plunger rod 126 is received within the cavity 162.
  • the cavity 162 is configured to center the distal end 128 of the plunger rod 126 therein.
  • the taper e.g., slope
  • the centering portion 152 gradually reduces the angle between the longitudinal axis 132 and the axis of displacement 154 as the distal end 128 of the plunger rod 126 contacts and slides along the tapered surface of the centering portion 152 so as to align the longitudinal axis 132 of the plunger rod 126 to be parallel to the axis of displacement 154.
  • the longitudinal axis 132 is substantially parallel to the axis of displacement 154 as the actuation body 148 displaces the plunger rod 126 within the barrel 122 to dispense medicament therefrom.
  • This alignment or centering reduces or prevents failure of the barrel 122 or proper functioning of the device 100, may prevent or limit displacement of the stopper 124 and plunger rod 126 within the barrel 122, and/or otherwise prevent proper functioning of the syringe assembly 120 such that the proper dosage of medicament is not dispensed from the drug delivery device 100.
  • the actuation body 148 may comprise a protruding surface rather than a recessed surface that is configured to center the plunger rod 126 with the actuation body 148.
  • an engagement surface 150' of the actuation body 148 may comprise a distal planar surface 170 and a protrusion 172 extending axially and proximally beyond the planar surface 170 in the proximal direction 153.
  • the protrusion 172 may comprise at least one centering portion configured to center the distal end 128 of the plunger rod 126.
  • the centering portion acts on the plunger rod 126 to vary (e.g., reduce) the angle between the longitudinal axis 132 and the axis of displacement 154 so as to align the longitudinal axis 132 of the plunger rod 126 to be parallel to the axis of displacement 154.
  • the at least one centering portion of the protrusion 172 may comprise at least one tapered portion such that the protrusion 172 decreases gradually and/or intermittently in the lateral dimension in the proximal direction.
  • the protrusion 172 may comprise a first tapered portion 174. In other embodiments, the protrusion 172 may comprise the first tapered portion 174 and a second tapered portion 176. The first tapered portion 174 may be located in front of the second tapered portion 176 in the proximal direction 153. An untapered portion 175 may be provided between the first and second tapered portions 174, 176.
  • the second tapered portion 176 may have a greater lateral dimension than the first tapered portion 174. Put differently, the minimum lateral dimension of the first tapered portion 174 may be less than the minimum lateral dimension of the second tapered portion 176.
  • the distal end 128 of the plunger rod 126 may comprise the cavity 178 recessed relative to a distal planar surface 177 in the proximal direction. The cavity 178 is configured to receive the protrusion 172 of the actuation body 148 therein.
  • the cavity 178 may comprise at least one tapered portion.
  • the cavity 178 comprises a first tapered portion 180 and a second tapered portion 182.
  • the first tapered portion 180 may be located in front of the second tapered portion 182 in the proximal direction 153.
  • An untapered portion 181 may be located between the tapered portions 180, 182.
  • the first and second tapered portions 180, 182 of the cavity 178 may be complementary in shape to the first and second tapered portions 174, 176 of the protrusion 172, respectively.
  • the untapered portion 181 of the cavity 178 may be complementary in shape to the shape of the untapered portion 175 of the protrusion 172.
  • a longitudinal axis of the untampered portion 175 of the protrusion may be coaxial with a longitudinal axis of the untapered portion 181 of the cavity 178.
  • the longitudinal axis of the untampered portion 181 will be coaxial with the longitudinal axis 132 of the plunger rod 126.
  • the lateral dimension of the cavity 178 along the first tapered portion 180 may be greater than or equal to the lateral dimension of the protrusion 172 along the first tapered portion 174, and the lateral dimension of the cavity 178 along the second tapered portion 182 may be greater than or equal to the lateral dimension of the protrusion 172 along the second tapered portion 176.
  • An axial dimension (e.g., length) of the cavity 178 may be substantially equal to or greater than an axial dimension of the protrusion 172.
  • the planar surface 170 of the actuation body 148 may abut against the planar surface 177 of the plunger rod 126.
  • the first tapered portion 174 of the protrusion 172 contacts the second tapered portion 182 of the cavity 178 prior to being received in the untapered portion 181 or the first tapered portion 180 of the cavity 178. Subsequently, the first tapered portion 174 of the protrusion 172 contacts the first tapered portion 180 of the cavity 178 and the second tapered portion 174 contacts the second tapered portion 180 of the cavity 178.
  • the taper e.g., slope
  • the taper e.g., slope of the first and second tapered portions 174, 176 and the corresponding taper of the first and second tapered portion 180, 182 of the cavity 178 varies the angle between the longitudinal axis 132 and the axis of displacement 154 so as to align the longitudinal axis 132 of the plunger rod 126 to be parallel to the axis of displacement 154.
  • the longitudinal axis 132 is substantially parallel to the axis of displacement 154 as the actuation body 148 displaces the plunger rod 126 within the barrel 122 to dispense medicament therefrom.
  • the protrusion 172 and cavity 178 may be configured to align the longitudinal axis 132 of the plunger rod 126 to be coaxial with the longitudinal axis 131 extending central through the barrel 122 when the plunger rod 126 is engaged with the actuation body 148 having the engagement surface 150'.
  • the protrusion 172 may comprise a longitudinal axis 171 and the cavity 178 may comprise a longitudinal axis 173, and the protrusion 172 and thecavity 178 may be configured such that the longitudinal axes 171, 173 are coaxial when the plunger rod 126 is engaged with the actuation body 148 having the engagement surface 150'.
  • aligning the longitudinal axis 132 with the axis of displacement 154 centers the plunger rod 126 relative to the actuation body 148 and allows the plunger rod 126 and the stopper 124 to be axially displaced by the actuation body 148 within the barrel 122 with limited to no lateral displacement of the plunger rod 126 and stopper 124 in the barrel 122. Accordingly, this alignment reduces or prevents the force of the actuation body 148 from acting on the plunger rod 126 in a manner that drives the plunger rod 126 and/or the stopper 124 laterally toward the inner wall barrel 122. Further, in comparison to the embodiment of FIGS. 2A and 2B, the size of the actuation body 148 can be reduced in order to make the device 100 more compact.
  • the interface of the plunger rod 126 between the actuation device 148 and the engagement surfaces 150, 150' associated therewith may be employed in other drug delivery devices.
  • the plunger rod 126 and the actuation device 148 having the engagement surface 150, 150' as described herein may be incorporated into drug delivery devices as described in US Pat. No. 9,526,837, entitled “Automatic Injection Device,” issued December 27, 2016, and in US Pat. No. 7,976,499, entitled “Automatic Injection Device,” issued July 12, 2011, the disclosure of each of which is incorporated herein in its entirety by this reference.

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  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne un dispositif d'administration de médicament qui comprend un ensemble d'entraînement configuré pour déplacer une tige de piston à l'intérieur d'un cylindre. L'ensemble d'entraînement comprend un corps d'actionnement mobile entre une position verrouillée dans laquelle le déplacement de l'ensemble d'entraînement est empêché et une position libérée dans laquelle le déplacement de l'ensemble d'entraînement dans une direction proximale est autorisé. Le corps d'actionnement comprend une surface de mise en prise configurée pour entrer en contact avec une extrémité distale de la tige de piston. La surface de mise en prise comporte une partie de centrage pour guider la mise en prise de l'extrémité distale de la tige de piston avec la surface de mise en prise du corps d'actionnement pour aligner un axe longitudinal de la tige de piston de façon à être parallèle à un axe de déplacement le long duquel le corps d'actionnement se déplace lors du déplacement de l'ensemble d'entraînement de la position verrouillée à la position libérée.
PCT/EP2021/068587 2020-07-08 2021-07-06 Dispositif d'administration de médicament WO2022008480A1 (fr)

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0426632A2 (fr) * 1989-10-28 1991-05-08 Atlas Copco Berema Aktiebolag Moteur à percussion
US5219099A (en) * 1991-09-06 1993-06-15 California Institute Of Technology Coaxial lead screw drive syringe pump
US20040152979A1 (en) * 2003-02-04 2004-08-05 Nemoto Kyorindo Co., Ltd. Liquid injection system for detecting when piston pusher of liquid injector grips piston flange of liquid syringe
US7862543B2 (en) * 2002-08-05 2011-01-04 Glide Pharmaceutical Technologies Limited Drug delivery system
US7976499B2 (en) 2006-04-11 2011-07-12 Becton, Dickinson And Company Automatic injection device
NO338662B1 (no) * 2004-05-28 2016-09-26 Cilag Gmbh Int Injeksjonsanordning
US9526837B2 (en) 2012-09-05 2016-12-27 Becton Dickinson France Automatic injection device
US10046115B2 (en) * 2012-07-05 2018-08-14 Unl Holdings Llc Drive control mechanisms and automatic injectors for injectable cartridges

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0426632A2 (fr) * 1989-10-28 1991-05-08 Atlas Copco Berema Aktiebolag Moteur à percussion
US5219099A (en) * 1991-09-06 1993-06-15 California Institute Of Technology Coaxial lead screw drive syringe pump
US7862543B2 (en) * 2002-08-05 2011-01-04 Glide Pharmaceutical Technologies Limited Drug delivery system
US20040152979A1 (en) * 2003-02-04 2004-08-05 Nemoto Kyorindo Co., Ltd. Liquid injection system for detecting when piston pusher of liquid injector grips piston flange of liquid syringe
NO338662B1 (no) * 2004-05-28 2016-09-26 Cilag Gmbh Int Injeksjonsanordning
US7976499B2 (en) 2006-04-11 2011-07-12 Becton, Dickinson And Company Automatic injection device
US10046115B2 (en) * 2012-07-05 2018-08-14 Unl Holdings Llc Drive control mechanisms and automatic injectors for injectable cartridges
US9526837B2 (en) 2012-09-05 2016-12-27 Becton Dickinson France Automatic injection device

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