WO2021258639A1 - Procédé d'évaluation d'effet thérapeutique dans une ablation par micro-ondes sur la base d'un champ de température simulé - Google Patents

Procédé d'évaluation d'effet thérapeutique dans une ablation par micro-ondes sur la base d'un champ de température simulé Download PDF

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WO2021258639A1
WO2021258639A1 PCT/CN2020/132359 CN2020132359W WO2021258639A1 WO 2021258639 A1 WO2021258639 A1 WO 2021258639A1 CN 2020132359 W CN2020132359 W CN 2020132359W WO 2021258639 A1 WO2021258639 A1 WO 2021258639A1
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Prior art keywords
ablation
simulated
data
temperature field
temperature
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PCT/CN2020/132359
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English (en)
Chinese (zh)
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蔡惠明
钱志余
冯宇
方舟
晋晓飞
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南京诺源医疗器械有限公司
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Publication of WO2021258639A1 publication Critical patent/WO2021258639A1/fr

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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/40—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B34/00—Computer-aided surgery; Manipulators or robots specially adapted for use in surgery
    • A61B34/10—Computer-aided planning, simulation or modelling of surgical operations
    • A61B2034/101—Computer-aided simulation of surgical operations

Definitions

  • the invention relates to the medical field, and in particular to a method for evaluating the therapeutic effect of microwave ablation based on a simulated temperature field.
  • Microwave thermal ablation therapy is considered to be another new and effective treatment method for malignant tumors after surgery, chemotherapy, radiotherapy, immunotherapy, etc., because of its obvious curative effect, minimal invasiveness, less toxic and side effects, and fewer complications. It has played a huge role in tumor treatment and has been widely used in common tumors such as liver cancer, lung cancer, and kidney cancer.
  • One of the most important is the problem of real-time efficacy evaluation in microwave ablation therapy. At present, clinically, the degree of ablation of tumor tissue cannot be accurately reflected.
  • the establishment of an intraoperative synchronous microwave ablation simulation model to achieve real-time evaluation of the efficacy has become a difficult point for precise ablation.
  • the process of tumor hyperthermia involves the process of heat generation and heat dissipation.
  • the size and shape of the temperature field are not only affected by the shape of the heating radiator, emission power, action time and other factors, but also related to the thermal conductivity and blood perfusion rate of the tumor tissue.
  • isothermal properties Due to the high complexity of human tissue and the limitations of measurement methods, the above-mentioned biological visualization indicators are often difficult to accurately measure; also in liver tissue, it is also difficult to understand the distribution of the three-dimensional temperature field through precise temperature measurement at multiple points.
  • Temperature field simulation is an important part of the preoperative planning system of microwave hyperthermia surgery, which can help doctors effectively predict the distribution of thermal field.
  • the current main thermotherapy temperature data are based on body models or animal liver experiments, and the current simulation simulation is simulated before surgery, and doctors cannot effectively evaluate the temperature field during the operation.
  • the purpose of the present invention is to overcome the shortcomings in the prior art and provide a method for evaluating the curative effect of microwave ablation based on a simulated temperature field.
  • the present invention adopts the following technical solutions to solve the above technical problems:
  • a method for evaluating the curative effect of microwave ablation based on simulated temperature field which includes the following steps:
  • the method of drawing the temperature at any point includes: obtaining the mouse position of the user, obtaining the temperature value of the corresponding position and refreshing with time;
  • the ablation length and short path and the change curve include: selecting the ablation area according to the ablation boundary temperature input by the user, and querying the ablation area
  • the maximum and minimum values of the abscissa and ordinate, the long diameter a and short diameter b of the ablation area are estimated according to the maximum and minimum values of the abscissa and ordinate, and the visualization index is refreshed according to time changes;
  • the ablation volume and change curve include: estimation of the ablation area according to the long diameter a and short diameter b Volume, the calculation formula is:
  • Alarming the treatment progress according to the preset treatment end information includes: reading the long diameter and short diameter of the treatment cut-off boundary input by the user, judging the long diameter and short diameter of the current simulated ablation border in real time, and setting the current ablation long and short diameter to the preset cut-off The boundary long diameter and short diameter are compared. If the long diameter or short diameter is greater than the preset value, an automatic alarm will be automatically issued.
  • the missing data filling includes cyclically checking the original simulation data to determine whether it is missing at the original resolution, and automatically filling it with the closest non-missing value if there is a missing value, and filling it row by row.
  • the generating of the linear spacing vector includes generating two vectors with a size of 512, which are respectively used to represent the abscissa x and the ordinate y of the temperature field, and the beginning and the end of the vector respectively read the abscissa and ordinate of the original simulation data.
  • the calculation of the actual distance between the two points includes the calculation of the stretching ratio coefficient of the horizontal and vertical coordinates of the display window, the acquisition of the horizontal and vertical coordinates of the two points and the calculation of the pixel distance, and the actual distance calculation formula is:
  • Y represents the length of the display window
  • X represents the width of the display window
  • x represents the abscissa of the current data
  • y represents the ordinate of the current data.
  • the simulated 3D simulation effect diagram is obtained by rotating a certain temperature line of the 2D simulation image along the central axis for one cycle.
  • the present invention adopts the above technical solutions and has the following technical effects:
  • Figure 1 is a flow chart of a method for evaluating therapeutic effects in microwave ablation based on a simulated temperature field provided by the present invention
  • Figure 2 is a schematic diagram of the lack of value filling of a method for evaluating the therapeutic effect of microwave ablation based on a simulated temperature field provided by the present invention
  • Fig. 3 is a schematic diagram of two-dimensional linear interpolation of a method for evaluating therapeutic effects in microwave ablation based on a simulated temperature field provided by the present invention.
  • Fig. 4 is a visualization interface of a method for evaluating therapeutic effects in microwave ablation based on a simulated temperature field provided by the present invention.
  • FIG. 1 it is a flow chart of a method for evaluating therapeutic effects in microwave ablation based on a simulated temperature field of the present invention. According to the simulation result of the discrete coordinate position of the temperature field, evaluate and visualize the actual curative effect state of the temperature field and various visualization indicators, including the following steps:
  • the missing data filling includes cyclically checking the original simulation data to determine whether it is missing at the original resolution. If there is a missing value, it will be automatically filled with the closest non-missing value and filled line by line; generating linear spacing vectors includes generating separately Two vectors with a size of 512 are used to represent the abscissa (x) and ordinate (y) of the temperature field. The first and end of the vectors read the maximum and minimum values of the abscissa of the original simulation data.
  • the high-resolution simulation temperature field topographic map after the difference is drawn, including: corresponding temperature and color, and plotting points according to pixel coordinates.
  • the corresponding process of temperature and color is to normalize the temperature value of 512*512 points to 0-255, and calculate the RGB value according to the jot topographic map specification.
  • the calculation method of isotherms includes: selecting data points with temperature values of 40°C, 50°C, 60°C, 70°C, 80°C, 90°C, 100°C, 110°C, 120°C, and performing data points with the same temperature value.
  • the drawing point connection; the boundary line drawing process is to read the boundary temperature input by the user, find the temperature data point, and connect the data points to the drawing point;
  • the calculation of the actual distance between the two points includes: the calculation of the stretching ratio coefficient of the horizontal and vertical coordinates of the display window, Obtain the horizontal and vertical coordinates of two points, calculate the pixel distance, and calculate the actual distance.
  • the calculation formula is:
  • the method of drawing the temperature at any point includes: obtaining the user's mouse position, obtaining the temperature value of the corresponding position, and refreshing with time (Resolution is 1s); simulated 3D simulation renderings, obtained by rotating a certain temperature line of the 2D simulation image along the central axis for one circle; ablation length and short diameter and change curve include: according to the ablation boundary temperature input by the user, select the ablation area and query the ablation area The maximum and minimum values of the abscissa and ordinate, the long and short diameters a and b of the ablation area are estimated according to the maximum and minimum values of the abscissa, and the parameters are refreshed according to time changes and the change curve is drawn (time resolution is 1s); the ablation volume and change curve include: Estimating the volume of the ablation area and drawing the change curve according to the
  • Alarming the treatment process according to the preset treatment end information includes: reading the long diameter and short diameter of the treatment cut-off boundary input by the user and judging the long diameter and short diameter of the current simulated ablation border in real time, and comparing the current long diameter and short diameter of ablation with The preset cut-off boundary long diameter and short diameter comparison, if the long diameter or short diameter is greater than the preset value, it will automatically alarm and automatically alarm.
  • 1 is the boundary line display button
  • 2 is the isotherm display button
  • 3 is the measurement button
  • 4 is the single-point temperature measurement button
  • 5 is the 3D/2D rendering conversion button
  • 6 is the clear screen display visualization indicator button
  • 7 is Simulation display screen
  • 9 is the display frame of long and short diameter
  • 10 is the change curve of long and short diameter.
  • microwave ablation when the treatment is started, the simulation display screen 7 will display the treatment simulation animation in synchronization with the treatment process, and the time resolution of the image refresh is 1 second; after the treatment starts, the time progress bar 8 will time according to the real time.
  • the diameter change curve will be drawn at a refresh rate of 1 second.
  • FIG. 3 it is the reading sequence of the simulation data used in the present invention.
  • the data search and missing data filling used in the present invention adopts horizontal data reading.
  • FIG 4 it is a schematic diagram of the difference filling algorithm used in the invention.
  • the present invention adopts two-dimensional linear interpolation, based on the principle of triangulation, that is, the temperature p1, p2, p3 of 3 points in the known plane, u and v exist at any point P in the triangle (because the triangle is a 2D figure , There are only two degrees of freedom, so as long as u and v are enough), so that
  • Point P is in the triangle, so (u,v) must satisfy the conditions u ⁇ 0, v ⁇ 0, u+v ⁇ 1.
  • u and v reflect the weight contribution of each vertex to a specific area, and (1-u-v) is the third weight.
  • (1-u-v) is the third weight.
  • the weighted average of the color values of P1, P2, and P3 can get the temperature value of point P.
  • the present invention obtains low-resolution tumor thermal ablation discrete coordinate position temperature values through simulation, and quickly obtains high-resolution topographic maps of the temperature field and various important visual indicators of the temperature field through simple operations; the simulation results are synchronized with the operation process , The time resolution is high, various visual indicators can be displayed simultaneously in real time, and automatic alarms are set; the evaluation method is low in cost and high in accuracy.

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  • Health & Medical Sciences (AREA)
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  • Public Health (AREA)
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Abstract

L'invention concerne un procédé d'évaluation d'effet thérapeutique dans une ablation par micro-ondes sur la base d'un champ de température simulé, consistant à : S1, construire un algorithme d'interpolation de données de champ de température en points discrets; S2, dessiner une carte topographique de champ de température simulé à haute résolution après la différence, comprenant la correspondance de la température aux points de couleur et de dessin en fonction de coordonnées de point de pixel; S3, calculer des indicateurs visuels de données interpolées, comprenant des calculs de : l'isotherme, la ligne de limite, la distance réelle entre deux points, la température de tout point, un graphique d'effet de simulation 3D simulé, des diamètres longs et courts d'ablation et une courbe de changement, et le volume d'ablation et une courbe de changement; S4, visualiser et afficher de manière synchrone le résultat de simulation et la progression de traitement peropératoire; et S5, signaler le processus de traitement conformément à des informations de fin de traitement prédéfinies. Le procédé d'évaluation d'effet thérapeutique dans l'ablation par micro-ondes sur la base d'un champ de température simulé présente un faible coût et une précision élevée.
PCT/CN2020/132359 2020-06-23 2020-11-27 Procédé d'évaluation d'effet thérapeutique dans une ablation par micro-ondes sur la base d'un champ de température simulé WO2021258639A1 (fr)

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CN114861279A (zh) * 2022-05-24 2022-08-05 中国水利水电科学研究院 水工混凝土结构温度仿真一致性检验方法及其检验系统
CN117637173A (zh) * 2023-11-29 2024-03-01 南京诺源医疗器械有限公司 微波消融参数的确定方法、装置及电子设备

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CN113842210A (zh) * 2021-08-02 2021-12-28 应葵 椎骨肿瘤微波消融手术仿真方法及装置

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