WO2021257006A1 - A phytomedicine and its derivatives effective against hand, foot and mouth disease (hfmd) based upon oroxylum indicum - Google Patents

A phytomedicine and its derivatives effective against hand, foot and mouth disease (hfmd) based upon oroxylum indicum Download PDF

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Publication number
WO2021257006A1
WO2021257006A1 PCT/TH2021/000015 TH2021000015W WO2021257006A1 WO 2021257006 A1 WO2021257006 A1 WO 2021257006A1 TH 2021000015 W TH2021000015 W TH 2021000015W WO 2021257006 A1 WO2021257006 A1 WO 2021257006A1
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WO
WIPO (PCT)
Prior art keywords
extract
indicum
plant part
leaves
pharmaceutical composition
Prior art date
Application number
PCT/TH2021/000015
Other languages
English (en)
French (fr)
Inventor
Boonrat TASSANEETRITAP
Chintana PHAWONG
Natsajee NUALKAEW
Thongkoon PRIENGPROM
Jantip SAELEE
Original Assignee
Mahidol University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mahidol University filed Critical Mahidol University
Priority to CN202180035984.5A priority Critical patent/CN115666609A/zh
Publication of WO2021257006A1 publication Critical patent/WO2021257006A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Definitions

  • Fig. 1 is a graph showing cytotoxicity test results with respect to different concentration of crude extraction of O. indicum on viability of the Vero cell lines used;
  • the disclosed composition may adopt an emulsified formulation for being administered orally that the like emulsified formulation may comprise one or more buffering agent and/or stabilizer to preserve the emulsion prepared thus facilitating absorption of the bioactive compounds.
  • the disclosed composition may take the form of cream, lotion, ointment, etc. to be applied topically on the skin especially foot and hands of the subject inflicted with lesions thereto.
  • the extract is acquired by way of bringing the plant part into contact with an extraction solvent for a predetermined of period.
  • the corresponding bioactive compounds resided in the plant parts of the O. indicum becomes dissolved into the solvent upon contacting with the solvent hence being extracted out from the matrix of the plant parts.
  • the used solvent is subsequently concentrated to remove the solvent until acquiring the extract preferably in a powder form.
  • the used solvent can be removed or concentrated by drying under vacuum or reduced pressure. It is possible to remove the used solvent through heating despite exposing the extract to excessive heating may risk to decomposing the bioactive compounds.
  • the extraction begins with cleaning the leaves, roots, rootbarks, and barks of O.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)
PCT/TH2021/000015 2020-06-15 2021-04-30 A phytomedicine and its derivatives effective against hand, foot and mouth disease (hfmd) based upon oroxylum indicum WO2021257006A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202180035984.5A CN115666609A (zh) 2020-06-15 2021-04-30 一种基于Oroxylum indicum的对手足口病(HFMD)有效的植物药及其衍生物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TH2001003373 2020-06-15
TH2001003373 2020-06-15

Publications (1)

Publication Number Publication Date
WO2021257006A1 true WO2021257006A1 (en) 2021-12-23

Family

ID=79268150

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TH2021/000015 WO2021257006A1 (en) 2020-06-15 2021-04-30 A phytomedicine and its derivatives effective against hand, foot and mouth disease (hfmd) based upon oroxylum indicum

Country Status (2)

Country Link
CN (1) CN115666609A (zh)
WO (1) WO2021257006A1 (zh)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102366428B (zh) * 2007-08-07 2013-10-09 北京北大维信生物科技有限公司 中草药木蝴蝶提取物在制备减肥降脂药物或制备具有脂肪酶活性抑制作用的药物中的应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101711796B (zh) * 2008-10-06 2012-10-24 北京五和博澳医药科技发展有限公司 黄芩黄酮在制备治疗肠道病毒感染药物的应用
KR101646009B1 (ko) * 2015-11-25 2016-08-08 강원대학교산학협력단 오록실린(oroxylin) A 화합물을 유효성분으로 함유하는 엔테로 바이러스에 기인한 질환의 예방 및 치료용 조성물

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102366428B (zh) * 2007-08-07 2013-10-09 北京北大维信生物科技有限公司 中草药木蝴蝶提取物在制备减肥降脂药物或制备具有脂肪酶活性抑制作用的药物中的应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MOHAMAT SYUHADARATUL AINI; SHUEB RAFIDAH HANIM; CHE MAT NOR FAZILA: "Anti-viral Activities ofOroxylum indicumExtracts on Chikungunya Virus Infection", INDIAN JOURNAL OF MICROBIOLOGY., HISAR, IN, vol. 58, no. 1, 28 November 2017 (2017-11-28), IN , pages 68 - 75, XP036424027, ISSN: 0046-8991, DOI: 10.1007/s12088-017-0695-8 *
SANNIGRAHI S, SANNIGRAHI, MISHRA, SINHAMAHAPATRA, NAYAK, DAS: "In vitro Antioxidant Potential of Different Parts of Oroxylum indicum: A Comparative Study", INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, MEDKNOW PUBLICATIONS PVT LTD., IN, vol. 72, no. 2, 1 March 2010 (2010-03-01), IN , pages 267, XP055894369, ISSN: 0250-474X, DOI: 10.4103/0250-474X.65013 *
SHRIKANT V. J. ET AL.: "Protective effect of aqueous extract of Oroxylum indicum Linn. (root bark) against DNBS-induced colitis in rats", INDIAN J PHARMACOL, vol. 43, no. 6, November 2011 (2011-11-01), pages 656 - 661, DOI: 10.4103/0253-7613.89821 *

Also Published As

Publication number Publication date
CN115666609A (zh) 2023-01-31

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