WO2021251920A1 - Utilisation de propolis obtenue par un procédé d'extraction spécial dans des mélanges liquides - Google Patents

Utilisation de propolis obtenue par un procédé d'extraction spécial dans des mélanges liquides Download PDF

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Publication number
WO2021251920A1
WO2021251920A1 PCT/TR2020/051486 TR2020051486W WO2021251920A1 WO 2021251920 A1 WO2021251920 A1 WO 2021251920A1 TR 2020051486 W TR2020051486 W TR 2020051486W WO 2021251920 A1 WO2021251920 A1 WO 2021251920A1
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charactarized
propolis
grams
product according
liquid
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PCT/TR2020/051486
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English (en)
Inventor
Asli Elif TANUĞUR SAMANCI
Taylan Samanci
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Sbs Bi̇li̇msel Bi̇o Çözümler Sanayi̇ Ve Ti̇caret A.Ş.
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Publication of WO2021251920A1 publication Critical patent/WO2021251920A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
    • A23L21/20—Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Definitions

  • the invention relates to propolis products.
  • the invention relates in particular to liquid propolis products which can be used in many sectors such as food, health and cosmetics that offer them for human consumption in their most suitable and in the highest form of bioavailability, in a fast and easy consumable state by properly extracting propolis which cause development of antioxidant, antimicrobial, antifungal, antivirus, anti - inflammatory, anti - cancerogen and anesthetic effects as well as many beneficial biological activities, and production methods thereof.
  • Propolis is a bee product which the bees process the resinous substances that they collect from the buds and bodies of plants.
  • the bees produce propolis for protecting the hive against micro - organisms and external factors by repairing the cracks in the hive with propolis.
  • the bees use the resins of mostly poplar and pinaceae while producing this.
  • Propolis basically has antimicrobial, anti - inflammatory, antioxidant, anti - cancerogen and anesthetic effects, and it provides supporting the immunity system as well. Because of the fact that it is being used frequently in important fields such as medical, apitherapy, healthy nutrition and biocosmetic fields, it is a rather popular component.
  • Propolis basically comprises 150 chemical compounds, more than 20 minerals, beeswax, resin and pollen.
  • Propolis which is produced by bees to protect their hives cannot be consumed as it is taken from the hive because it comprises high content of beeswax and parasites which try to reach the honey in the hive.
  • propolis In order for propolis to be converted to a suitable form for human consumption, it is necessary to remove the beeswax and impurities in its content. Following removal of beeswax and other impurities from propolis with its bioavailability of 2 % in its raw state, the bioavailability can rise up to 100 %.
  • our body employs propolis that converted to completely pure form composed of antioxidant substances such as phenolic and flavonoid.
  • Chinese patent application number CN105560289A relates to the preparation technique of liquid propolis.
  • Said technology includes the following steps: disintegration of propolis raw material, preparation of a liquid mixture composed of caprilic / capric triglyceride, propylene glycol, glycerin, pure water and an amount of alcohol mixture, mixing both components, filling liquid propolis mixture and packaging.
  • propolis content information written on the label is wrong, or extraction methods are insufficient. It is necessary for the raw propolis to be extracted correctly due to the indigestible components such as impurities and beeswax in its content, and to be supplied to consumption in its highest state of bioavailability by preserving the beneficial components in its content in the maximum amount. Antioxidant content and bioavailability of the products in the market are rather low.
  • the composed mixtures comprise components which can be harmful to human health. The insufficient content of these products which are bought to increase body resistance and to fight with diseases is not suitable for the purpose.
  • propolis direct consumption of propolis is rather difficult due to its bitter taste and resinous structure. Therefore, products available in the market use many additives and chemicals to overcome this consumption difficulty. The purpose of using these chemicals is to bring in solubility to the resinous structure and to try to mask the bitter taste with the artificial sweeteners used. Moreover, the firms are unable to purify propolis correctly or import it from countries such as China. Residue and additive problems are frequently encountered in the imported propolis. Consequently, the firms are obliged to add chemical preservatives and additives to the final product due to the fact that they cannot make use of the antioxidant, antimicrobial, antifungal and similar bioactive effects of propolis. And this in turn causes the product to attain an undesirable condition.
  • the present invention relates to liquid propolis products which meet the above mentioned requirements, which eliminate all disadvantages and which offer some additional advantages, and its method of production and liquid propolis product.
  • the prioritized purpose of the invention is to provide the method to obtain a properly extracted liquid propolis extract with high bioavailability and liquid propolis product.
  • An object of the invention is to provide a liquid propolis product and a method of obtaining liquid propolis extract without side effects or drug-food interaction.
  • Another purpose of invention is to form the steps applied during the method in a way not to disturb the stability of propolis product in a suitable and efficient result manner.
  • Another purpose of invention is to obtain properly extracted liquid propolis extract with high flavonoid content which causes development of antioxidant, antimicrobial, antifungal, antivirus, anti - inflammatory, anti - cancerogen and anesthetic effects as well as many beneficial biological activities.
  • the invention relates to a method of obtaining liquid propolis product which comprises the following process steps and which has high antioxidant capacity (a) disintegrating the raw propolis by passing it through a grinder; (b) mixing the disintegrated propolis with at least one fruit juice selected from a group consisting of ethyl alcohol, propylene glycol, ultra pure water, balsam apple and black elderberry extract and a solvent selected from a group consisting of carob extract; (c) mixing the obtained solution by adding lemon juice or apple cider vinegar as acid regulator; (d) shaking the degassed solution; (e) degassing the shaken solution in ultrasonic bath; (f) centrifuging the degassed solution; (g) removal of volatile substances by drying the centrifuged mixture in a rotary evaporator until the extent of dryness; (a) disintegrating the raw propolis by passing it through a grinder; (b) mixing the disintegrated propolis with at least one fruit juice selected from a group consisting of ethyl alcohol, propylene glycol,
  • the invention also includes the propolis products obtained by the above mentioned method and the use of these products for healthy nutrition, apitherapy and biocosmetic purposes in food, health and cosmetics sectors.
  • liquid propolis products of the invention and production methods thereof are described aimed at only better understanding of the subject and without forming any limiting effects.
  • the invention relates in particular to liquid propolis products which can be used in many sectors such as food, health and cosmetics that offer them for human consumption in their most suitable and in the highest form of bioavailability, in a fast and easy consumable state by properly extracting propolis which cause development of antioxidant, antimicrobial, antifungal, antivirus, anti - inflammatory, anti-cancerogen and anesthetic effects as well as many beneficial biological activities, and production methods thereof.
  • the invention is also a liquid propolis extract suitable for healthy nutrition, apitherapy and biocosmetic purposes for use in food, health and cosmetic sectors offered as drops, syrup or drinks wherein liquid propolis obtained by extracting pure propolis with of at least one fruit juice selected from ethyl alcohol, propylene glycol, ultrapure water, potion pomegranate and black elderberry extract; and a solvent selected from group consisting of carob extract; and lemon juice or apple cider vinegar as acid regulator comprises honey, ginseng, royal jelly, pomegranate, at least one fruit juice selected from black elderberry extract, perga, pollen, salt, menthol and/or spices.
  • the raw propolis cannot be digested directly due to the indigestible components such as impurities and beeswax in its content; it has to be freed of the impurities by extracting with a solvent.
  • Table 1 preferred raw materials of the invention and their amounts in the method of invention are given.
  • the liquid propolis product which has been developed accordingly comprise honey preferably in an amount from 12.5 % to 37.5 % (more preferably 25 %) based on total weight, salt preferably in an amount from 12.5 % to 37.5 % (more preferably 25 %) based on total weight, ginseng preferably in an amount from 0.5 % to 2.5 % (more preferably 1 %) based on total weight, royal jelly preferably in an amount from 0.5 % to 2.5 % (more preferably 1 %) based on total weight menthol preferably in an amount from 0.05 % to 0.5 % (more preferably 0.25 %) based on total weight, spices preferably in an amount from 0.05 % to 0.5 % (more preferably 0.25 %) based on total weight, pollen preferably in an amount from 0.5 % to 2.5 % (more preferably 1 %) based on total weight, - perga preferably in an amount from 0.5 % to 2.5 % (more preferably 1 %) based on total weight.
  • Raw propolis is a plantal substance in the form of a sticky resin which is collected by bees from the trees and carried to the hives. It is a bee product having natural antibiotic property. Propolis which has a natural antibiotic property causes implementation of antioxidant, antimicrobial, antifungal, antivirus, anti - inflammatory, anti - cancerogen and anesthetic effects as well as many useful biological activities. It reinforces the immunological system. It is known to be effective against cancer, inflammatory diseases, diseases of viral and bacterial origin. The raw propolis should be freed of the impurities by extraction since it cannot be directly consumed due to the indigestible components such as impurities and beeswax in its content. Therefore, the raw propolis should be extracted with the correct solvents.
  • Solvent should be freed of the impurities by extraction since it cannot be directly consumed due to the indigestible components such as impurities and beeswax in its content.
  • Solvent is the agent which provides the dissolution of the raw propolis and transport of the active materials.
  • as a solvent at least one fruit juice selected from the group consisting of suitable for use in foods ethanol (ethanol) with a purity of more than 90%, propylene glycol, pomegranate and black elderberry extract; carob extract or ultrapure are used.
  • Fruit juices mentioned herein can use different solvents which are not harmful against human health according to the form and composition of the desired final product to be obtained by pomegranate juice, orange juice, strawberry juice, apple juice, peach juice, sour cherry juice or similar fruit juices.
  • Solvents which are not suitable for human health such as methanol, ethyl acetate, chloroform and hexane are not preferred in the invention.
  • Ethanol, ethyl alcohol or plantal alcohol is a colorless chemical compound obtained from plants. It is currently being used as solvent in vitamin syrups.
  • Ultra pure water is the more purified state of pure water. Pure water is the water in which mineral substances present in the water have been removed. And ultra pure water is water with a conductivity value of 0.055 pS / cm (25 ⁇ ) or electrical resistivity of 18.2 Megaohm - cm.
  • Propylene glycol is a petroleum oil derivative compound that has many uses in the commercial industry. It is odorless and it does not have any certain taste definition. Propylene glycol is being used in food, cosmetics, pharmaceutical and plastics industries. Ethyl alcohol and propylene glycol are suitable to be used in foods and are not subjected to any dissolver heating process.
  • Balsam apple extract Balsam apple (Momordica charantia) is being used in diabetes patients as an alternative treatment for lowering the glycose levels in the blood. Research on animals and humans show balsam apple to comprise hypoglisemic substances. In a study made on mice, the results have shown a significant increase in b cell count in the animals treated with M. charantia as compared to untreated diabetes patients. M. charantia extracts are being used as a potentially cytotoxic agent for certain cancer types in addition to being used in clinical conditions such as diabetes, dyslipidemia, microbial infections.
  • balsam apple extract modulates the signal pathways for the inhibition of breast cancer cell growth and that it could be used as a diet supplement for preventing breast cancer.
  • Black elderberry extract is a good source of protein, and they are the free and conjugated form of amino acids, unsaturated fatty acids, fiber fractions, vitamins, antioxidants and minerals.
  • Polyphenols comprise mostly anthocyanins, flavonols, phenolic acids and proanthocyanidins as well as high biological activity components such as terpens and lectins.
  • Anthocyanins and other flavonoids show antioxidant, anticarcinogenic, immuno - stimulating, antibacterial, antiallergic and antiviral properties; therefore their consumption can contribute to the prevention of various degenerative diseases such as cardiovascular disease, cancer, inflammatory diseases and diabetes.
  • Acid regulating substance is being used to increase the acidity of the solution consisting of propolis and solvent in the method of obtaining high flavonoid content propolis extract of the invention.
  • solvent preferably 1 ml of lemon juice can be used as acid regulating substance.
  • propylene glycol, carob extract or at least one of the above mentioned fruit juices is being used as solvent, preferably 1 ml of apple cider vinegar can be used as acid regulating substance.
  • Different acid regulators too can be preferred for different solvents other than these.
  • Ginger turmeric and cinnamon are preferably being used as spices in a preferred embodiment of the invention.
  • Spices are food supplements that have been used as flavoring and coloring agents and as preservatives for thousands of years.
  • the digestion stimulating effect, hypolipidemic effect, antidiabetic effect, antilithogenic property, antioxidant potential, anti - inflammatory property, antimutagenic and anticarcinogenic properties of the spices have been documented.
  • hypocholesterolemic and antioxidant properties of a few specific spices have a wide range nutraceutical value. These useful physiological effects also have possible therapeutical treatment potential under various disease conditions.
  • Turmeric (Curcuma longa) is used in many urinary disases, liver diseases and in jaundice.
  • Turmeric extract and curcumin isolated from it are rather cytotoxic in mammalian cells and are effective in reducing animal tumors and shows potential of usage in cancer treatment.
  • Ginger Zaingiber officinale Rose.
  • Ginger is one of the richest sources of antioxidants which cleanse the free radicals and the health inconsistencies that they bring along with them.
  • Ginger comprises gingerols as active components which exhibit antioxidant activity determined by in vitro studies.
  • Pollen is a product of a great veriety and rich in biologically active substances. In pollen grains from different plant kinds 200 substances have been found. Proteins, amino acids, carbohydrates, lipids and fatty acids, phenolic compounds, enzymes and coenzymes, vitamins and bioelements are included in the fundamental chemical substances. Bee pollen is used in apitherapeutical treatment since it shows a series of actions such as antifungal, antimicrobial, antiviral, antiinflammatory, immuno-stimulant and local analgesic action and also because it facilitates the granulation process of burn wound healing. Bee pollen is a precious nutritive substance and a natural product of honey bee advertized as a source of energy.
  • the health promoting value of bee pollen originates from the presence of enzymes and co-enzymes in the bee pollen as well as secondary plant metabolites (tocopherol, niacine, thiamine, biotine and folic acid, polyphenols, carotenoid pigments, phytosterols).
  • enzymes and co-enzymes in the bee pollen as well as secondary plant metabolites (tocopherol, niacine, thiamine, biotine and folic acid, polyphenols, carotenoid pigments, phytosterols).
  • ginseng include ginsenosids, polysaccharides, peptides, polyacetilenic alcohols and fatty acids.
  • ginsenosids polysaccharides
  • peptides polypeptides
  • polyacetilenic alcohols fatty acids
  • fatty acids a wide variation in the ginsenosid content of different ginseng species.
  • ginseng There are many clinical studies on ginseng to characterize its therapeutic properties such as improvement of physical performance, cancer treatment, diabetes and hypertension.
  • Royal jelly is a very precious bee product having a great number of functional properties such as antibacterial activity, anti - inflammatory activity, vasodilatative and hypotensive activities, disinfectant effect, antioxidant activity, antihypercholesterolemic activity and antitumor activity.
  • Salt currently plays a multi-purpose role in many produced foods and drinks in addition to its roles in human physiology, nutrition and health.
  • Salt which encompasses sodium and chlorine in its content is an important compound in meeting the sodium requirement of the body in addition to giving flavor.
  • Salt also possesses specific properties which are important for the processing of these products in many food products.
  • Salt possesses an effect primarily on the water activity and a protective duty against microbes generally in combination with other antimicrobial agents in addition the mentioned properties. In addition to its protective duty, it provides stability of the product by effecting the acid base balance. Salt content in the products not only effects their tastes but also their microbiological shelf life and in some instances their texture and mouthfeel too.
  • Menthol plant oriented menthol is the product of natural distillation of mint leaves. Menthol which is structurally similar to mint is denser in terms of elements that it comprises. Menthol which is used in food usually to give aroma is also antiseptic for the intestines with its anti - inflammatory and vasodilatator property. It plays an important role in the treatment of respiratory tract diseases. Menthol is being preferred in respiratory tract ailments and in allergical situations in nasal sprays with its anesthetic and deconjestant properties.
  • Perga is pollen in the form of pellets collected by the bees and carried back to the hive by mixing them with their own digestive enzymes, comprising a little amount of honey and beeswax.
  • perga which is formed by melting of the outer membrane of the pollens encompasses many useful microorganisms thereby showing probiotic property.
  • Perga which comprises many vitamins, phenolics and antioxidants is also being used as a natural food supplement.
  • honey as a sweetener.
  • Honey is a natural product that changes the plant nectars, secretions in the living parts of the plants or the secretions of the plant sucking insects living on the living parts of the plants by combining them with specific substances after being collected by the honey bee, reducing the water content and maturing by storing with honeycomb.
  • Honey which is a source of vitamins and minerals has a lot of benefits to the body, especially in the immunological system.
  • lemon juice can be used as acid regulating substance in the amounts given in Table 1.
  • apple cider vinegar can be used as acid regulating substance in the amounts given in Table 1.
  • a sample is taken from the supernatant which is formed following the centrifuging process, and bioavailable phenolic flavonoid substance content which the propolis comprises is analyzed in LC - MSMS (Liquid Chromatography - Mass / Mass Spectrometer).
  • MSMS Liquid Chromatography - Mass / Mass Spectrometer
  • the condition of galangine, pinocembrin, crisine, cinnamic acid to be above 10 mg / g and p - coumaric acid, ferulic acid, cafeic acid phenethyl ester (CAPE) to be above 5 mg / g is sought.
  • dry matter determination of the sample is carried out.
  • said solution is again subjected to the processes of continuous stirring in a medium temperature of 20 - 30 ⁇ C for at least 7 d ays in darkness; degassing in an ultrasonic bath for 3 hours at 25 ‘C; centrifuging at 10 000 g for 20 - 30 minutes, in sequence.
  • a new sample is taken from the supernatant which forms as a result of centrifuging process and phenolic flavonoid substance content is analyzed again in LC - MSMS.
  • At least one fruit juice selected from the extract of black elderberry extract; honey, ginseng and royal jelly are added to the mixture that solvents are removed by drying.
  • Perga, pollen, salt, menthol and / or spices are added to the mixture.
  • the mixture is stirred in a homogenizer preferably at 30 ‘C preferably for 15 - 30 minutes and is degassed in an ultrasonic bath. Filling and packaging of the final products are carried out to be offered to the health and cosmetics sector for the purpose of healthy nutrition, apytherapy and biocosmetics.
  • Useful components that are present in the propolis are preserved by the method described above, and products which have high bioavailability, which are suitable for human consumption, in different liquid forms such as drops, syrups, drinks and in consumption ways can be produced.

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Insects & Arthropods (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Animal Husbandry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Jellies, Jams, And Syrups (AREA)

Abstract

L'invention concerne des produits liquides de propolis qui peuvent être utilisés dans de nombreux secteurs tels que des aliments, la santé et les cosmétiques qui les contiennent pour une consommation humaine dans leur forme la plus appropriée et sous la forme de biodisponibilité la plus élevée, dans un état de consommation rapide et facile par extraction appropriée de propolis qui provoquent le développement d'effets antioxydants, antimicrobiens, antifongiques, antiviraux, anti-inflammatoires, anti-cancérogènes et anesthésiques, ainsi que de nombreuses activités biologiques bénéfiques, et des procédés de production associés.
PCT/TR2020/051486 2020-06-08 2020-12-31 Utilisation de propolis obtenue par un procédé d'extraction spécial dans des mélanges liquides WO2021251920A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2020/08787A TR202008787A2 (tr) 2020-06-08 2020-06-08 Özel ekstraksi̇yon yöntemi̇ i̇le elde edi̇len propoli̇si̇n sivi karişimlarda kullanilmasi
TR2020/08787 2020-06-08

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115873411A (zh) * 2022-10-26 2023-03-31 凤阳加松新型材料科技有限公司 一种抗病毒硅胶垫的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2070543A1 (fr) * 2007-12-12 2009-06-17 Bios Line S.p.a. Procédé à haute efficacité pour la production d'un extrait de propolis
CN101978969A (zh) * 2010-10-22 2011-02-23 王志军 蜂胶溶液的制备方法
TR201908777A2 (tr) * 2019-06-13 2019-07-22 Sbs Bilimsel Bio Coezuemler Sanayi Ve Ticaret A S Suda Çözünür ve Suda Çözünür Olmayan Özellikte Yüksek Antioksidan Kapasitesine Sahip Propolis Ürünleri ve Üretim Yöntemi

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2070543A1 (fr) * 2007-12-12 2009-06-17 Bios Line S.p.a. Procédé à haute efficacité pour la production d'un extrait de propolis
CN101978969A (zh) * 2010-10-22 2011-02-23 王志军 蜂胶溶液的制备方法
TR201908777A2 (tr) * 2019-06-13 2019-07-22 Sbs Bilimsel Bio Coezuemler Sanayi Ve Ticaret A S Suda Çözünür ve Suda Çözünür Olmayan Özellikte Yüksek Antioksidan Kapasitesine Sahip Propolis Ürünleri ve Üretim Yöntemi

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115873411A (zh) * 2022-10-26 2023-03-31 凤阳加松新型材料科技有限公司 一种抗病毒硅胶垫的制备方法
CN115873411B (zh) * 2022-10-26 2023-10-13 凤阳加松新型材料科技有限公司 一种抗病毒硅胶垫的制备方法

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