WO2021213363A1 - Implant de lentille intraoculaire complet pour la cataracte congénitale - Google Patents

Implant de lentille intraoculaire complet pour la cataracte congénitale Download PDF

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Publication number
WO2021213363A1
WO2021213363A1 PCT/CN2021/088305 CN2021088305W WO2021213363A1 WO 2021213363 A1 WO2021213363 A1 WO 2021213363A1 CN 2021088305 W CN2021088305 W CN 2021088305W WO 2021213363 A1 WO2021213363 A1 WO 2021213363A1
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WO
WIPO (PCT)
Prior art keywords
ring
intraocular lens
boss
adjustable
shaped
Prior art date
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PCT/CN2021/088305
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English (en)
Chinese (zh)
Inventor
杨愔
彭群
田奎
Original Assignee
西安眼得乐医疗科技有限公司
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Publication of WO2021213363A1 publication Critical patent/WO2021213363A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1662—Instruments for inserting intraocular lenses into the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2002/1681—Intraocular lenses having supporting structure for lens, e.g. haptics
    • A61F2002/16901—Supporting structure conforms to shape of capsular bag
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/0097—Coating or prosthesis-covering structure made of pharmaceutical products, e.g. antibiotics

Definitions

  • the present invention mainly relates to the technical field of ophthalmic intraocular lens, and more specifically relates to an integrated intraocular lens implant for congenital cataract.
  • the most basic function of the human eye is to transmit light through the cornea, the transparent refractive part at the front of the eye, and then gather on the retina after imaging through the natural lens to achieve visual function.
  • the quality of the focused image depends on many factors, including the size and shape of the eye and the transparency of the cornea and natural lens. Aging, heredity, immune and metabolic abnormalities, trauma and other reasons cause metabolic disorders in the natural lens, leading to protein denaturation of the natural lens. This phenomenon is called cataract in medicine.
  • the most effective way to treat cataracts is to surgically remove the natural lens and then replace it with an artificial lens. Most of the cataract lens is removed by a surgical procedure-phacoemulsification.
  • the ultra-emulsion probe needs to go deep into the small incision of the anterior capsular bag to break the cloudy natural lens and cortex into chylo, and then suck out the chylo with the aid of a suction and perfusion system. After the cloudy natural lens is removed, an intraocular lens is implanted.
  • An intraocular lens is an artificial lens that can be implanted in the eye. After the turbid natural lens is removed during cataract surgery, the artificial lens is implanted into the eye to replace the original natural lens for vision correction. Replacement of intraocular lens is currently the most effective treatment for cataract.
  • the most commonly used intraocular lens in the market is an open-loop intraocular lens, such as the SN60WF intraocular lens produced by ALCON, the ZCB00 intraocular lens produced by AMO, etc.
  • These intraocular lenses are mainly for senile cataract patients, and are they suitable for congenital cataract patients? There are many controversies.
  • the average refractive power shift from infancy to adolescence is 5 to 6D, and the eye axis becomes longer, leading to more and more myopia. It is quite difficult to reach the ideal refractive power in adulthood. (5) Compared with ordinary aging intraocular lenses, the placement time of intraocular lenses in children is almost a lifetime, and the possibility of intraocular lens replacement is increased.
  • one method is to directly place an intraocular lens suitable for the child after the cataract surgery, leaving a 20% shortfall during the operation Diopter, after the operation, you must wear glasses to correct your vision. I hope that the offset can be compensated for in puberty.
  • the refractive results of this treatment method are often unsatisfactory, and there are still fibrosis and recurrence caused by the severe inflammatory reaction after the above-mentioned operation. It also makes surgery difficult for the required replacement intraocular lens and increases the risk of capsular bag damage.
  • Another method is to keep the capsular bag after the cataract removal operation, but do not place the intraocular lens to allow the baby to wear corrective glasses, and wait until the baby reaches a certain age before placing the intraocular lens.
  • This method is called secondary implantation.
  • the placement position of the secondary intraocular lens depends on the condition of the capsular bag after the operation. If the capsular bag is intact and there is no shrinkage, fibrosis or adhesion, the intraocular lens can be directly implanted into the capsular bag. This possibility is quite small. .
  • the capsular bag of most patients undergoes severe contraction, fibrosis, and adhesion after cataract surgery. The intraocular lens cannot be placed in the capsular bag at a later stage.
  • the intracapsular ring implanted in the capsular bag can not only maintain the shape of the capsular bag, but also reserve a place for the intraocular lens to be placed.
  • the intraocular lens implanted in the capsular bag has better long-term safety; therefore, the integrated intraocular lens implant composed of the intracapsular ring and the intraocular lens provides a new alternative for patients with congenital cataracts.
  • the invention provides an integrated intraocular lens implant for congenital cataracts.
  • the integrated intraocular lens implant consists of an adjustable intra-capsular ring and an intraocular lens arranged on the adjustable intra-capsular ring.
  • an adjustable intracapsular ring can be implanted before cataract removal.
  • the intracapsular ring maintains the contour of the pediatric capsular bag to the greatest extent.
  • the lens is implanted at the right time. It is also possible to implant the entire combination in one operation according to the needs of the patient.
  • Both the adjustable intracapsular ring and the intraocular lens can be made of biocompatible materials such as silica gel, polymethyl methacrylate, hydrophobic acrylate, and cross-linked polyolefin materials.
  • An integrated intraocular lens implant for congenital cataracts including an adjustable intracapsular ring and an intraocular lens assembled on the adjustable intracapsular ring;
  • the adjustable intracapsular ring includes a ring-shaped body and an artificial lens for assembling artificial
  • the boss of the lens is arranged on the inner surface of the ring-shaped body, the ring-shaped body has a closed-loop structure or a C-shaped open-loop structure. The circumference can be in contact with the inner surface of the capsular bag.
  • one intraocular lens or two intraocular lenses are assembled on the adjustable intracapsular ring.
  • the intraocular lens is assembled on the front side of the boss and/or the back side of the boss.
  • the ring-shaped body when the ring-shaped body is a C-shaped open-loop structure, the ring-shaped body is composed of a segment of arc structure; when the ring-shaped body is a closed-loop structure, the ring-shaped body is connected by two or more segments of arc structures through the connecting portion As a result, the connecting portion has a V-shaped or U-shaped structure, and the opening of the V-shaped or U-shaped structure faces outward.
  • a plurality of bosses are provided in the ring-shaped main body, and a notch groove is provided between two adjacent bosses; the thickness H1 of the ring-shaped main body is greater than the thickness H2 of the bosses.
  • the ring-shaped main body and the boss are integrally formed.
  • the outer surface of the ring-shaped body is a planar structure, a concave arc structure or a convex arc structure; the cross-sectional shape of the boss is a rectangle or a trapezoid.
  • the boss is provided with a first through hole; the first through hole is a waist-shaped, polygonal, or circular through hole, and the first through hole is used to ensure the flow of the aqueous humor from the front and rear or for placement Sustained release drugs.
  • the ring-shaped body is provided with a second through hole; the second through hole is a waist-shaped, polygonal or circular through hole, and the second through hole is used to ensure the flow of the aqueous humor from the front and rear or for placement Sustained release drugs.
  • annular body and/or the boss is provided with a blind hole for placing a slow-release drug, and the blind hole is waist-shaped, polygonal or circular.
  • the ring body, the boss and the intraocular lens are all made of biocompatible materials; no polymerizable dye is added or added to the biocompatible materials; the biocompatible materials
  • the materials are silica gel, polymethyl methacrylate, hydrophobic acrylate or cross-linked polyolefin materials.
  • the intraocular lens includes an optical surface and a loop; the optical surface of the intraocular lens is any one of a spherical surface, an aspheric surface, astigmatism or a multifocal optical surface, and the intraocular lens has two or more loops.
  • the adjustable intracapsular ring and the intraocular lens are implanted in the same operation.
  • the adjustable intracapsular ring and the intraocular lens are implanted separately in multiple operations.
  • the invention relates to a comprehensive intraocular lens implant for congenital cataracts, including an adjustable intracapsular ring and an intraocular lens arranged on the adjustable intracapsular ring.
  • the adjustable intracapsular ring is a specially designed intraocular lens
  • the ring which has a certain thickness, shape and elasticity, can maintain the contour and elasticity of the pediatric capsular bag after the cataract is removed, and prevent the capsular bag from being severely contracted due to the absence of natural crystals.
  • the intracapsular ring can not only produce corresponding size changes with the growth of the pediatric capsular bag, but also prevent the migration of epithelial cells. More importantly, the structure of the adjustable intracapsular ring is specially designed to accept the intraocular lens implanted later.
  • the adjustable intracapsular ring is used in the capsular bag to provide convenience for the second implantation of the intraocular lens. It is no longer necessary to put the loop of the intraocular lens into the ciliary sulcus, which greatly reduces the stimulation to the ciliary sulcus and reduces the possibility of pigmentation and glaucoma.
  • the intraocular lens placed on the adjustable intracapsular ring is used in conjunction with the adjustable intracapsular ring. It consists of an optical part and a loop part.
  • the optical part can be any spherical, aspheric or multifocal intraocular lens.
  • the design of the loop can be
  • the intraocular lens can be placed on the inner ring of the capsule, and the intraocular lens can be fixed in the center. It is possible to add through holes or/and blind holes on the inner ring of the capsule for placing sustained-release drugs to effectively reduce and control postoperative inflammation.
  • the intraocular lens placed on the adjustable intracapsular ring can be replaced according to the needs of the patient, and it can also be added to the adjustable intracapsular ring
  • An intraocular lens is used to change the diopter, because the adjustable intracapsular ring also reserves a place for the second artificial lens. The above methods can effectively solve the problem of continuous diopter changes in adolescent cataract patients.
  • FIG. 1 is a schematic diagram of the structure of the adjustable intracapsular ring described in Example 3;
  • Example 2 is a schematic diagram of the structure of the adjustable intracapsular ring described in Example 4.
  • FIG. 3 is a schematic diagram of the structure of the adjustable inner ring of the capsule according to the embodiment 5;
  • Example 4 is a schematic diagram of the structure of the adjustable intracapsular ring described in Example 6;
  • Fig. 5 is a schematic structural diagram of the adjustable intra-capsular ring of embodiment 7;
  • Example 6 is a schematic diagram of the structure of the adjustable inner ring of the capsule in Example 8.
  • FIG. 7 is a schematic diagram of the structure of the adjustable inner ring of the capsule according to the embodiment 9;
  • Fig. 9 is a partial enlarged view of a concave arc structure on the outer side of the ring body
  • Fig. 10 is a partial enlarged view of a convex arc structure on the outer side of the ring body
  • FIG. 11 is a partial enlarged view of the cross-sectional shape of the ring-shaped main body being a trapezoid
  • FIG. 12 is a schematic diagram of the structure of the adjustable intracapsular ring of embodiment 17;
  • FIG. 13 is a schematic diagram of the structure of the adjustable intracapsular ring of embodiment 18;
  • Example 14 is a schematic diagram of the structure of the adjustable intra-capsular ring described in Example 19;
  • 15 is a schematic diagram of the structure of the adjustable intracapsular ring of embodiment 20;
  • FIG. 16 is a schematic diagram of the structure of the adjustable intracapsular ring of embodiment 21;
  • 17 is a schematic diagram of the structure of the adjustable intra-capsular ring of embodiment 22;
  • Figure 18 is a schematic diagram of the meaning designation of the front side, the back side and the inner side of the ring body and the boss;
  • Example 19 is a schematic diagram of the structure of the integrated intraocular lens implant for congenital cataract described in Example 26;
  • Example 20 is a schematic diagram of the structure of the integrated intraocular lens implant for congenital cataract described in Example 27;
  • Example 21 is a schematic diagram of the structure of the integrated intraocular lens implant for congenital cataract described in Example 28;
  • 1 ring body, 11 arc structure, 12 connecting part, 13 second through hole, 2 boss, 21 notch groove, 22 first through hole, 23 blind hole, H1 thickness of ring body, H2 convex The thickness of the platform, the front side of the A1 ring body, the back side of the B1 ring body, the inner side of the C1 ring body, the outer side of the D1 ring body, the front side of the A2 boss, the back side of the B2 boss, The inner side of the C2 boss.
  • the integrated intraocular lens implant for congenital cataracts of the present invention includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100.
  • the adjustable intracapsular ring 100 includes a ring A shaped body 1 and a boss 2 for assembling an intraocular lens.
  • the annular body 1, the boss 2, and the intraocular lens 200 of the adjustable intracapsular ring 100 are all made of biocompatible materials; the biocompatible materials may not be added or added with polymerizable dyes. When dyes of different colors are added, the manufactured adjustable intracapsular ring 100 presents different colors, so that the intracapsular ring can be clearly distinguished during surgical implantation.
  • the material with biocompatibility can be silica gel, polymethyl methacrylate, hydrophobic acrylate, and cross-linked polyolefin material.
  • the sustained-release medicine mentioned in the present invention can effectively reduce and control postoperative inflammation.
  • the shape of the first through hole 22, the second through hole 13 and the blind hole 23 of the present invention may be other shapes in addition to the shapes listed in this specification, as long as the functions described in the present invention can be realized.
  • the adjustable intracapsular ring of this embodiment includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens.
  • the boss 2 is provided on the inner side of the ring body 1.
  • the boss 2 is located at the lower part of the thickness of the ring body 1, the thickness H1 of the ring body 1 is greater than the thickness H2 of the boss 2, the boss The front side of 2 is lower than the front side of the ring body 1, and the rear side of the boss 2 is higher than the back side of the ring body 1.
  • the ring body 1 is a closed-loop structure, and the ring body 1 consists of two or two sections
  • the above arc structure 11 is connected by a connecting portion 12, the connecting portion 12 is a V-shaped or U-shaped structure, the opening of the V-shaped or U-shaped structure faces outward, and the ring-shaped body 1 and the boss 2 are One-piece structure.
  • the adjustable intracapsular ring of this embodiment includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens.
  • the boss 2 is provided on the inner surface of the ring body 1.
  • the boss 2 is located at the upper part of the thickness of the ring body 1, the thickness H1 of the ring body 1 is greater than the thickness H2 of the boss 2, the boss The front side of 2 is lower than the front side of the ring body 1, and the rear side of the boss 2 is higher than the back side of the ring body 1.
  • the ring body 1 has a C-shaped open-loop structure, and the ring body 1 is a section of circle.
  • the arc structure 11 is formed, and the ring-shaped body 1 and the boss 2 are integrally formed.
  • the adjustable intracapsular ring described in this embodiment is shown in Fig. 1, and includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens.
  • the ring-shaped body 1 and the boss 2 are an integral structure.
  • the main body 1 has a C-shaped open-loop structure, the boss 2 is provided on the inner side of the ring-shaped main body 1, and the ring-shaped main body 1 is composed of a section of arc structure 11, and the inner side of the ring-shaped main body 1 is provided with two protrusions.
  • a notch 21 is provided between the two bosses 2.
  • the thickness H1 of the ring body 1 is greater than the thickness H2 of the boss 2.
  • the boss 2 is located in the middle of the thickness of the ring body 1, and the front side of the boss 2 is low On the front side of the ring body 1, the back side of the boss 2 is higher than the back side of the ring body 1.
  • the outer circumference of the annular body 1 can contact the inner surface of the capsule.
  • the outer surface of the ring-shaped body 1 is a plane structure
  • the cross-sectional shape of the ring-shaped body 1 is a rectangle
  • the cross-sectional shape of the boss 2 is a rectangle.
  • the adjustable intracapsular ring described in this embodiment is shown in Fig. 2. It includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens.
  • the ring-shaped body 1 and the boss 2 are integrally formed.
  • the main body 1 has a closed-loop structure.
  • the boss 2 is provided on the inner side of the ring-shaped main body 1.
  • the ring-shaped main body 1 is formed by connecting two arc structures 11 through a connecting portion 12, and the connecting portion 12 is a V-shaped structure.
  • the opening of the V-shaped structure faces outward, the inner side of the ring-shaped body 1 is provided with two bosses 2, and a gap groove 21 is provided between the two bosses 2, and the thickness H1 of the ring-shaped body 1 is greater than that of the bosses.
  • the thickness of the boss 2 is H2
  • the boss 2 is located in the middle of the thickness of the ring body 1, the front side of the boss 2 is lower than the front side of the ring body 1, and the back side of the boss 2 is higher than the back side of the ring body 1.
  • the boss 2 is provided with a first through hole 22; the first through hole 22 is a waist-shaped through hole, and the first through hole 22 is used to ensure the flow of front and back aqueous humor or to place a slow-release drug .
  • the outer circumference of the annular body 1 can contact the inner surface of the capsule.
  • the cross-sectional shape of the annular body 1 is rectangular, and the cross-sectional shape of the boss 2 is rectangular.
  • the adjustable intracapsular ring described in this embodiment is shown in Fig. 3, and includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens.
  • the ring-shaped body 1 and the boss 2 are integrally formed.
  • the main body 1 has a C-shaped open-loop structure
  • the boss 2 is provided on the inner side of the ring-shaped main body 1
  • the ring-shaped main body 1 is composed of a section of arc structure 11, and the inner side of the ring-shaped main body 1 is provided with two protrusions.
  • a notch 21 is provided between the two bosses 2.
  • the thickness H1 of the ring body 1 is greater than the thickness H2 of the boss 2.
  • the boss 2 is located in the middle of the thickness of the ring body 1, and the front side of the boss 2 is low On the front side of the ring body 1, the back side of the boss 2 is higher than the back side of the ring body 1.
  • the boss 2 is provided with a first through hole 22; the first through hole 22 is a circular through hole, and the annular body 1 is provided with a second through hole 13, and the second through hole 13 It is a circular through hole, and the first through hole 22 and the second through hole 13 are used to ensure the flow of aqueous humor before and after or to place a slow-release drug.
  • the outer circumference of the annular body 1 can contact the inner surface of the capsule.
  • the cross-sectional shape of the annular body 1 is rectangular, and the cross-sectional shape of the boss 2 is rectangular.
  • the adjustable intracapsular ring described in this embodiment is shown in Fig. 4, and includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens.
  • the ring-shaped body 1 and the boss 2 are an integral structure.
  • the main body 1 has a C-shaped open-loop structure, and the boss 2 is provided on the inner side of the ring-shaped main body 1.
  • the arc shape of the boss 2 is different from that of the embodiment 3.
  • the ring-shaped main body 1 is composed of a circular arc structure 11,
  • the inner side of the ring-shaped body 1 is provided with two bosses 2, and a gap groove 21 is provided between the two bosses 2.
  • the thickness H1 of the ring-shaped body 1 is greater than the thickness H2 of the bosses 2, and the bosses 2 are located in the ring In the middle of the thickness of the main body 1, the front side of the boss 2 is lower than the front side of the ring body 1, and the back side of the boss 2 is higher than the back side of the ring body 1.
  • the boss 2 is provided with a first through hole 22; the first through hole 22 is a waist-shaped through hole, and the first through hole 22 is used to ensure the flow of front and back aqueous humor or to place a slow-release drug .
  • the outer circumference of the annular body 1 can contact the inner surface of the capsule.
  • the cross-sectional shape of the ring-shaped body 1 is rectangular.
  • the adjustable bladder inner ring of this embodiment is shown in Fig. 5.
  • the difference from embodiment 6 is that a second through hole 13 is provided on the annular body 1, and the second through hole 13 is circular Through holes, the second through holes 13 are used to ensure the flow of aqueous humor before and after or to place slow-release drugs.
  • the remaining features are the same as those described in Example 6.
  • the adjustable intracapsular ring of this embodiment is shown in Fig. 6, and includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens.
  • the ring-shaped body 1 and the boss 2 are an integral structure.
  • the main body 1 has a closed-loop structure.
  • the boss 2 is provided on the inner side of the ring-shaped main body 1.
  • the ring-shaped main body 1 is formed by connecting two arc structures 11 through a connecting portion 12, and the connecting portion 12 is a U-shaped structure.
  • the opening of the U-shaped structure faces outward, and two bosses 2 are provided on the inner side of the ring-shaped body 1.
  • the arc shape of the bosses 2 is different from that of the third embodiment, and a notch groove is provided between the two bosses 2 21.
  • the thickness H1 of the ring body 1 is greater than the thickness H2 of the boss 2.
  • the boss 2 is located in the middle of the thickness of the ring body 1.
  • the front side of the boss 2 is lower than the front side of the ring body 1, and the back of the boss 2
  • the side surface is higher than the rear side surface of the ring body 1.
  • the adjustable bladder inner ring of this embodiment is shown in Fig. 7.
  • the difference from embodiment 8 is that the boss 2 is provided with a first through hole 22; the first through hole 22 is a circular through hole.
  • the ring-shaped body 1 is provided with a second through hole 13, the second through hole 13 is a circular through hole, the first through hole 22 and the second through hole 13 are used to ensure the front and rear aqueous humor It can be used to place slow-release drugs to effectively ensure the flow of aqueous humor before and after.
  • the remaining features are the same as those described in Example 8.
  • the adjustable bladder inner ring of this embodiment is shown in Fig. 8.
  • the difference from embodiment 4 is that a second through hole 13 is provided on the annular body 1, and the second through hole 13 is circular Through holes, the second through holes 13 are used to ensure the flow of aqueous humor before and after or to place slow-release drugs.
  • the remaining features are the same as those described in Example 4.
  • the adjustable inner bag ring of this embodiment is different from the embodiment 4 in that the ring-shaped body 1 is provided with a second through hole 13, and the second through hole 13 is a waist-shaped through hole, which is effective Ensure the flow of aqueous humor before and after.
  • the remaining features are the same as those described in Example 4.
  • the adjustable bladder ring of this embodiment is different from the embodiment 4 in that the ring body 1 is provided with a second through hole 13, and the second through hole 13 is a polygonal through hole, which effectively guarantees The flow of aqueous humor before and after.
  • the remaining features are the same as those described in Example 4.
  • the adjustable bladder inner ring of this embodiment is different from the embodiment 8 in that the boss 2 is provided with a first through hole 22; the first through hole 22 is a polygonal through hole, which effectively guarantees the front and rear The flow of aqueous humor.
  • the remaining features are the same as those described in Example 8.
  • the adjustable inner balloon ring of this embodiment is different from the embodiment 4 in that the outer surface of the ring body 1 is a concave arc structure, as shown in Fig. 9 a partial enlarged view.
  • the remaining features are the same as those described in Example 4.
  • the adjustable inner balloon ring of this embodiment is different from the embodiment 4 in that the outer surface of the ring body 1 is a convex arc structure, as shown in Fig. 10, a partial enlarged view.
  • the remaining features are the same as those described in Example 4.
  • the adjustable inner balloon ring of this embodiment is different from the third embodiment in that the cross-sectional shape of the annular body 1 is a trapezoid, as shown in FIG. 11, a partial enlarged view, and the cross-sectional shape of the boss 2 is a trapezoid.
  • the remaining features are the same as those described in Example 4.
  • the adjustable inner ring of the capsule in this embodiment is shown in Fig. 12.
  • the difference from embodiment 4 is that the front side of the boss 2 is also provided with a blind hole 23 for placing a slow-release drug. It is circular, the inner surface of the boss 2 is provided with a blind hole 23 for placing slow-release drugs, the blind hole is a waist-shaped groove, and the front side of the ring-shaped body 1 is also provided with a blind hole 23 for placing the slow-release drug.
  • the blind hole 23 of the medicine, the blind hole is circular.
  • the adjustable bladder inner ring of this embodiment is shown in Fig. 13.
  • the difference from the embodiment 17 is that the outer surface of the ring body 1 is a concave arc structure.
  • the remaining features are the same as those described in Example 17.
  • the adjustable balloon inner ring of this embodiment is shown in Fig. 14.
  • the difference from embodiment 10 is that the outer surface of the ring body 1 is a convex arc structure; the front side of the boss 2 A blind hole 23 for placing a slow-release drug is also provided, the blind hole is circular, the inner side of the boss 2 is provided with a blind hole 23 for placing a slow-release drug, and the blind hole is a waist-shaped groove.
  • the remaining features are the same as those described in Example 10.
  • the adjustable balloon inner ring of this embodiment is shown in Fig. 15.
  • the difference from embodiment 3 is that the outer surface of the ring body 1 is a concave arc structure; the inner surface of the boss 2 is provided There is a blind hole 23 for placing sustained-release drugs, and the blind hole is a waist-shaped groove.
  • the remaining features are the same as those described in Example 3.
  • the adjustable sac inner ring of this embodiment is shown in Fig. 16.
  • the front side of the boss 2 is also provided with a blind hole 23 for placing a slow-release drug.
  • the inner surface of the boss 2 is provided with a blind hole 23 for placing sustained-release drugs
  • the blind hole is a waist-shaped groove
  • the ring-shaped body 1 is provided with a second through hole 13
  • the second through hole 13 is a circular through hole
  • the second through hole 13 is used to ensure the flow of aqueous humor or to place slow-release drugs.
  • the outer surface of the ring body 1 is a convex arc structure. The remaining features are the same as those described in Example 6.
  • the adjustable intracapsular ring of this embodiment is shown in Fig. 17, and includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens.
  • the ring-shaped body 1 and the boss 2 are an integral structure.
  • the main body 1 has a closed-loop structure.
  • the boss 2 is provided on the inner side of the ring-shaped main body 1.
  • the ring-shaped main body 1 is formed by connecting two arc structures 11 through a connecting portion 12, and the connecting portion 12 is a V-shaped structure.
  • the opening of the V-shaped structure faces outward, and the thickness of the connecting portion 12 is the same as the thickness of the annular body 1.
  • the inner side of the ring-shaped body 1 is provided with two bosses 2, and a gap groove 21 is provided between the two bosses 2.
  • the thickness H1 of the ring-shaped body 1 is greater than the thickness H2 of the bosses 2, and the bosses 2 are located in the ring At the lower part of the thickness of the shaped body 1, the front side of the boss 2 is lower than the front side of the ring body 1, and the back side of the boss 2 and the back side of the ring body 1 are on the same plane.
  • the boss 2 is provided with a first through hole 22; the first through hole 22 is a waist-shaped through hole, and the first through hole 22 is used to ensure the flow of front and back aqueous humor or to place a slow-release drug .
  • the adjustable inner ring of the capsule in this embodiment is shown in Fig. 18.
  • the difference from the embodiment 10 is that the front side of the boss 2 is also provided with a blind hole 23 for placing a slow-release drug.
  • the inner surface of the boss 2 is provided with a blind hole 23 for placing a slow-release drug
  • the blind hole is a waist-shaped groove
  • the outer surface of the ring body 1 has a concave arc structure.
  • the integrated intraocular lens implant for congenital cataracts described in this embodiment includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100;
  • the adjustable intracapsular ring 100 includes a ring A shaped body 1 and a boss 2 for assembling an intraocular lens.
  • the boss 2 is arranged on the inner side of the ring-shaped body 1.
  • the ring-shaped body 1 has a closed-loop structure.
  • the integrated intraocular lens implant for congenital cataracts described in this embodiment includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100;
  • the adjustable intracapsular ring 100 includes a ring A shaped body 1 and a boss 2 for assembling an intraocular lens.
  • the boss 2 is arranged on the inner surface of the ring body 1.
  • the ring body 1 has a C-shaped open ring structure.
  • the integrated intraocular lens implant for congenital cataract described in this embodiment is shown in Fig. 19, which includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100;
  • the ring 100 includes a ring body 1 and a boss 2 for assembling an intraocular lens.
  • the boss 2 is arranged on the inner surface of the ring body 1.
  • the ring body 1 has a C-shaped open ring structure. After the inner ring is implanted in the capsular bag, the outer circumference of the annular body 1 can contact the inner surface of the capsular bag.
  • two different types of intraocular lenses 200 are assembled on the front side of the boss 2 and the back side of the boss 2 of the adjustable intracapsular ring 100.
  • the optical surface of the intraocular lens 200 can be spherical, aspherical, astigmatic or multi-faceted. There are two haptics of the intraocular lens 200 for any one of the optical surfaces such as the focal point.
  • the difference between the adjustable inner balloon ring 100 used in this embodiment and the adjustable inner balloon ring 100 described in Example 6 is that the upper surface of the boss 2 is also provided with a blind hole 23, and the boss 2 A blind hole 23 is provided on the inner side of the ring, and a blind hole 23 is also provided on the ring-shaped body 1.
  • the blind hole 23 is used for placing sustained-release drugs.
  • the remaining features are the same as those described in Example 6.
  • the integrated intraocular lens implant for congenital cataract described in this embodiment is shown in Fig. 20, which includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100; the adjustable intracapsular
  • the ring 100 includes a ring body 1 and a boss 2 for assembling an intraocular lens.
  • the boss 2 is arranged on the inner side of the ring body 1.
  • the ring body 1 is a closed ring structure. After being inserted into the capsular bag, the outer circumference of the annular body 1 can be in contact with the inner surface of the capsular bag.
  • an intraocular lens 200 is assembled on the front side of the boss 2 of the adjustable intracapsular ring 100.
  • the optical surface of the intraocular lens 200 can be any one of spherical, aspherical, astigmatic or multifocal optical surfaces.
  • the intraocular lens There are 2 loops of 200.
  • the adjustable inner bag ring 100 used in this embodiment is different from the embodiment 9 in that the inner surface of the boss 2 is provided with a blind hole 23.
  • the blind hole 23 is used for placing sustained-release drugs.
  • the remaining features are the same as those described in Example 9.
  • the integrated intraocular lens implant for congenital cataract described in this embodiment is shown in Fig. 21. It includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100;
  • the ring 100 includes a ring body 1 and a boss 2 for assembling an intraocular lens.
  • the boss 2 is arranged on the inner surface of the ring body 1.
  • the ring body 1 has a C-shaped open ring structure. After the inner ring is implanted in the capsular bag, the outer circumference of the annular body 1 can contact the inner surface of the capsular bag.
  • an intraocular lens 200 is assembled on the back side of the boss 2 of the adjustable intracapsular ring 100.
  • the optical surface of the intraocular lens 200 can be any one of spherical, aspherical, astigmatic or multifocal optical surfaces.
  • the intraocular lens There are 2 loops of 200.
  • the adjustable inner balloon ring 100 used in this embodiment is the adjustable inner balloon ring 100 described in Embodiment 21.
  • phacoemulsification is used to remove the cloudy natural lens of the cataract patient, and then select the adjustable intracapsular ring 100 suitable for the size of the patient's capsular bag, and slowly push the intracapsular ring into the patient with tweezers or a special intracapsular injection device. Inside the bag, and adjust the position of the adjustable inner ring 100;
  • an intraocular lens 200 can be placed on the front or back side of the boss 2 of the adjustable intracapsular ring 100 when appropriate.
  • the intraocular lens 200 placed on the adjustable intracapsular ring 100 can be replaced at an appropriate time according to the needs of the patient, or another intraocular lens 200 can be added to the intracapsular ring to change the diopter.
  • the manufacturing method of the integrated intraocular lens implant for congenital cataract of the present invention is the manufacturing method of the integrated intraocular lens implant for congenital cataract of the present invention.
  • Adjustable inner sac ring 100 It is injection molded into a blank, processed by mechanical processing, and then subjected to post-processing such as grinding, polishing, cleaning, and drying. After that, it is packaged and sterilized, and it is implanted into the human eye sac through a special injection device or tweezers. Inside.
  • Intraocular lens 200 After injection molding, the blank is mechanically processed, and then chemical treatment, cleaning, drying and other post-treatments are carried out, and then packaged and sterilized. After the intraocular lens bolus is implanted in the human eye capsule, it is placed in the capsule One side of the inner ring.
  • the intraocular lens 200 of the present invention may be an intraocular lens in the prior art or a new type of intraocular lens developed in the future. As long as it can be assembled on the boss 2 of the adjustable intracapsular ring 100 of the present invention, it is protected by the present invention. Design concept.
  • the integrated intraocular lens implant for congenital cataracts of the present invention includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100.
  • the adjustable intracapsular ring 100 An intraocular lens 200 can be mounted on it. According to the actual situation of the patient, place an intraocular lens 200 on the anterior or posterior side of the boss 2 of the adjustable intracapsular ring 100.
  • the intraocular lens can also be replaced according to the needs of the patient, and another intraocular lens can be added to the boss 2 200 to adjust the diopter of the patient.
  • the combined implants can be implanted separately.
  • the adjustable intracapsular ring 100 is first implanted to protect the pediatric capsular bag.
  • the intraocular lens 200 can be implanted in the adjustable intracapsular ring 100.
  • the adjustable intracapsular ring 100 and the intraocular lens 200 can also be implanted in one operation.
  • the unique structural design of the adjustable intracapsular ring 100 of the present invention enables the intracapsular ring to produce corresponding size changes with the growth of the pediatric capsular bag, maintain the circular contour of the capsular bag, and help maintain the normal lens capsular bag Physiological position to prevent tilt and eccentricity of the intraocular lens.
  • the intraocular lens is in contact with the inner surface of the adjustable intracapsular ring instead of the capsular bag, it reduces the surgical difficulty that the intraocular lens may adhere to the capsular bag and is not easy to remove.
  • the outer circumference of the ring body 1 can contact the inner surface of the capsular bag, which can play a barrier function and contact inhibition effect, prevent the proliferation and migration of lens epithelial cells, and reduce After the occurrence of cataract, to prevent the occurrence of turbidity of the capsule before and after.
  • the boss 2 is provided with a first through hole 22; the first through hole 22 is a waist-shaped, polygonal or circular through hole, and the first through hole 22 is used to ensure the front and back of the aqueous humor It is mobile or used to place sustained-release drugs.
  • the annular body 1 is provided with a second through hole 13; the second through hole 13 is a waist-shaped, polygonal, or circular through hole, and the second through hole 13 is used to ensure the flow or use of aqueous humor before and after. Place sustained-release drugs.
  • the annular body 1 and/or the boss 2 are provided with a blind hole 23 for placing a slow-release drug, and the blind hole is waist-shaped, polygonal or circular.
  • the ring-shaped body 1 and the boss 2 are made of biocompatible materials; the biocompatible materials may not be added or added with polymerizable dyes, and when necessary, they may have biological phases.
  • the polymerizable dye is added to the capacitive material, the adjustable intracapsular ring of the present invention presents different colors, which is convenient for making the intracapsular ring clearly distinguishable during surgical implantation.

Abstract

La présente invention concerne un implant de lentille intraoculaire complet pour la cataracte congénitale. L'implant de lentille intraoculaire complet comprend un anneau intracapsulaire ajustable (100) et une lentille intraoculaire commune (200) assemblée sur l'anneau intracapsulaire ajustable (100). L'anneau intracapsulaire ajustable (100) comprend un corps en forme d'anneau (1) et un bossage (2) utilisé pour assembler la lentille intraoculaire (200), le bossage (2) étant disposé sur la surface latérale interne du corps en forme d'anneau (1) et le corps en forme d'anneau (1) bénéficiant d'une structure en anneau fermé ou d'une structure en anneau ouvert en forme de C. L'anneau intracapsulaire ajustable (100) est un anneau intracapsulaire spécialement conçu qui présente une épaisseur, une forme et une élasticité spécifiques, le contour et l'élasticité d'un sac capsulaire de nourrisson pouvant être conservés après que le cristallin naturel a été retiré et la contraction du sac capsulaire provoquée par l'absence de cristallin naturel étant empêchée. L'anneau intracapsulaire ajustable (100) permet non seulement de générer un changement de taille correspondant conjointement avec la croissance du sac capsulaire de nourrisson afin d'empêcher la migration de cellules épithéliales, mais peut également être utilisé pour fixer une lentille intraoculaire implantée ultérieurement tout en facilitant l'implantation secondaire de la lentille intraoculaire dans le sac capsulaire.
PCT/CN2021/088305 2020-04-20 2021-04-20 Implant de lentille intraoculaire complet pour la cataracte congénitale WO2021213363A1 (fr)

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CN202010311743.6A CN111467077B (zh) 2020-04-20 2020-04-20 一种用于先天性白内障的综合人工晶状体植入体
CN202010311743.6 2020-04-20

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CN111467077B (zh) * 2020-04-20 2022-02-15 西安眼得乐医疗科技有限公司 一种用于先天性白内障的综合人工晶状体植入体

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