WO2021213363A1

WO2021213363A1 - Comprehensive intraocular lens implant for congenital cataract

Info

Publication number: WO2021213363A1
Application number: PCT/CN2021/088305
Authority: WO
Inventors: 杨愔; 彭群; 田奎
Original assignee: 西安眼得乐医疗科技有限公司
Priority date: 2020-04-20
Filing date: 2021-04-20
Publication date: 2021-10-28
Also published as: CN111467077A; CN111467077B

Abstract

A comprehensive intraocular lens implant for congenital cataract. The comprehensive intraocular lens implant comprises an adjustable intracapsular ring (100) and a common intraocular lens (200) assembled on the adjustable intracapsular ring (100). The adjustable intracapsular ring (100) comprises a ring-shaped body (1) and a boss (2) used for assembling the intraocular lens (200), the boss (2) is provided on the inner side surface of the ring-shaped body (1), and the ring-shaped body (1) is of a closed-ring structure or a C-shaped open-ring structure. The adjustable intracapsular ring (100) is an intracapsular ring which is specially designed and has certain thickness, shape and elasticity, the contour and elasticity of an infant capsular bag after the natural crystalline lens is removed can be kept, and capsular bag contraction caused by no natural crystalline lens is prevented. The adjustable intracapsular ring (100) not only can generate a corresponding size change along with the growth of the infant capsular bag to prevent migration of epithelial cells, but also can be used for fixing an intraocular lens implanted in the later period, and provides convenience for secondary implantation of the intraocular lens in the capsular bag.

Description

A comprehensive intraocular lens implant for congenital cataract

Technical field

The present invention mainly relates to the technical field of ophthalmic intraocular lens, and more specifically relates to an integrated intraocular lens implant for congenital cataract.

Background technique

The most basic function of the human eye is to transmit light through the cornea, the transparent refractive part at the front of the eye, and then gather on the retina after imaging through the natural lens to achieve visual function. The quality of the focused image depends on many factors, including the size and shape of the eye and the transparency of the cornea and natural lens. Aging, heredity, immune and metabolic abnormalities, trauma and other reasons cause metabolic disorders in the natural lens, leading to protein denaturation of the natural lens. This phenomenon is called cataract in medicine. At present, the most effective way to treat cataracts is to surgically remove the natural lens and then replace it with an artificial lens. Most of the cataract lens is removed by a surgical procedure-phacoemulsification. During the operation, the ultra-emulsion probe needs to go deep into the small incision of the anterior capsular bag to break the cloudy natural lens and cortex into chylo, and then suck out the chylo with the aid of a suction and perfusion system. After the cloudy natural lens is removed, an intraocular lens is implanted.

An intraocular lens (IOL) is an artificial lens that can be implanted in the eye. After the turbid natural lens is removed during cataract surgery, the artificial lens is implanted into the eye to replace the original natural lens for vision correction. Replacement of intraocular lens is currently the most effective treatment for cataract. At present, the most commonly used intraocular lens in the market is an open-loop intraocular lens, such as the SN60WF intraocular lens produced by ALCON, the ZCB00 intraocular lens produced by AMO, etc. These intraocular lenses are mainly for senile cataract patients, and are they suitable for congenital cataract patients? There are many controversies. The proportion of congenital cataract patients in the world population is 0.01-0.06%, and the proportion of congenital cataract patients in China is 0.05%. For pediatric patients with congenital cataract, the sooner the cataract is removed, the better, because cataract will hinder the development of vision. However, whether the intraocular lens is replaced at the same time as the cataract surgery, or what kind of intraocular lens is replaced is quite controversial.

The capsular bag of children aged two years and older is close to adults. Therefore, cataract surgery and intraocular lens replacement for children over two years old are internationally recognized methods for the treatment of children with congenital cataract; The following problems: (1) Postoperative inflammation leads to severe fibrotic uveitis and dense fibers. (2) Severe late-onset obstacles. (3) Place the intraocular lens in the ciliary sulcus with secondary implantation, resulting in secondary glaucoma. (4) Difficulties in biometric measurement before surgery lead to uncertainty in the calculation of diopter, and it is difficult to achieve the ideal diopter. In addition, the baby's refractive power shifts rapidly after the operation. The average refractive power shift from infancy to adolescence is 5 to 6D, and the eye axis becomes longer, leading to more and more myopia. It is quite difficult to reach the ideal refractive power in adulthood. (5) Compared with ordinary aging intraocular lenses, the placement time of intraocular lenses in children is almost a lifetime, and the possibility of intraocular lens replacement is increased.

At present, there are two main methods for congenital cataract surgery and intraocular lens placement for pediatric patients in the world: one method is to directly place an intraocular lens suitable for the child after the cataract surgery, leaving a 20% shortfall during the operation Diopter, after the operation, you must wear glasses to correct your vision. I hope that the offset can be compensated for in puberty. The refractive results of this treatment method are often unsatisfactory, and there are still fibrosis and recurrence caused by the severe inflammatory reaction after the above-mentioned operation. It also makes surgery difficult for the required replacement intraocular lens and increases the risk of capsular bag damage.

Another method is to keep the capsular bag after the cataract removal operation, but do not place the intraocular lens to allow the baby to wear corrective glasses, and wait until the baby reaches a certain age before placing the intraocular lens. This method is called secondary implantation. The placement position of the secondary intraocular lens depends on the condition of the capsular bag after the operation. If the capsular bag is intact and there is no shrinkage, fibrosis or adhesion, the intraocular lens can be directly implanted into the capsular bag. This possibility is quite small. . The capsular bag of most patients undergoes severe contraction, fibrosis, and adhesion after cataract surgery. The intraocular lens cannot be placed in the capsular bag at a later stage. Most of the second-implanted intraocular lenses can only be placed in the anterior ciliary sulcus of the capsular bag. The long-term safety of intraocular lens placement in the ciliary sulcus has always been quite controversial. The more serious side effect is secondary glaucoma. The relevant literature has found that the second time the intraocular lens is implanted into the ciliary sulcus in pediatric cataract patients produces secondary glaucoma. The main risk factors for

Therefore, it is of great significance to provide a comprehensive intraocular lens implant that can meet the requirements of pediatric congenital cataract patients.

Summary of the invention

(1) Technical problems to be solved by the present invention

(1) Solve the secondary glaucoma caused by most congenital cataract patients who need to be implanted into the ciliary sulcus intraocular lens twice. The intracapsular ring implanted in the capsular bag can not only maintain the shape of the capsular bag, but also reserve a place for the intraocular lens to be placed. The intraocular lens implanted in the capsular bag has better long-term safety; therefore, the integrated intraocular lens implant composed of the intracapsular ring and the intraocular lens provides a new alternative for patients with congenital cataracts.

(2) Solve the problem of inaccuracy of refractive power caused by the difficulty of preoperative biometric measurement in children and the problem of inaccurate refractive correction caused by the deviation of children's refractive power after surgery; provide patients with more suitable replacement intraocular lenses Plan.

(3) Reduce fibrosis caused by postoperative inflammatory reaction, and alleviate hindrance;

(4) Pediatric intraocular lens implantation capsular bag is placed for a long time, and the possibility of intraocular lens replacement is much higher than that of senile cataract patients. At the same time, the difficulty of long-term intraocular lens replacement surgery will increase due to fibrosis. Reduce the risk of capsular bag rupture caused by the replacement of the intraocular lens.

The invention provides an integrated intraocular lens implant for congenital cataracts. The integrated intraocular lens implant consists of an adjustable intra-capsular ring and an intraocular lens arranged on the adjustable intra-capsular ring. According to the actual situation of the patient, an adjustable intracapsular ring can be implanted before cataract removal. The intracapsular ring maintains the contour of the pediatric capsular bag to the greatest extent. There is a structure on the intracapsular ring that can accept intraocular lenses. The lens is implanted at the right time. It is also possible to implant the entire combination in one operation according to the needs of the patient. Provide patients with an alternative to replace the intraocular lens. Both the adjustable intracapsular ring and the intraocular lens can be made of biocompatible materials such as silica gel, polymethyl methacrylate, hydrophobic acrylate, and cross-linked polyolefin materials.

(2) The implementation process of the present invention is as follows:

An integrated intraocular lens implant for congenital cataracts, including an adjustable intracapsular ring and an intraocular lens assembled on the adjustable intracapsular ring; the adjustable intracapsular ring includes a ring-shaped body and an artificial lens for assembling artificial The boss of the lens, the boss is arranged on the inner surface of the ring-shaped body, the ring-shaped body has a closed-loop structure or a C-shaped open-loop structure. The circumference can be in contact with the inner surface of the capsular bag.

Further, one intraocular lens or two intraocular lenses are assembled on the adjustable intracapsular ring.

Further, the intraocular lens is assembled on the front side of the boss and/or the back side of the boss.

Further, when the ring-shaped body is a C-shaped open-loop structure, the ring-shaped body is composed of a segment of arc structure; when the ring-shaped body is a closed-loop structure, the ring-shaped body is connected by two or more segments of arc structures through the connecting portion As a result, the connecting portion has a V-shaped or U-shaped structure, and the opening of the V-shaped or U-shaped structure faces outward.

Further, a plurality of bosses are provided in the ring-shaped main body, and a notch groove is provided between two adjacent bosses; the thickness H1 of the ring-shaped main body is greater than the thickness H2 of the bosses.

Further, the ring-shaped main body and the boss are integrally formed.

Further, the outer surface of the ring-shaped body is a planar structure, a concave arc structure or a convex arc structure; the cross-sectional shape of the boss is a rectangle or a trapezoid.

Further, the boss is provided with a first through hole; the first through hole is a waist-shaped, polygonal, or circular through hole, and the first through hole is used to ensure the flow of the aqueous humor from the front and rear or for placement Sustained release drugs.

Further, the ring-shaped body is provided with a second through hole; the second through hole is a waist-shaped, polygonal or circular through hole, and the second through hole is used to ensure the flow of the aqueous humor from the front and rear or for placement Sustained release drugs.

Further, the annular body and/or the boss is provided with a blind hole for placing a slow-release drug, and the blind hole is waist-shaped, polygonal or circular.

Further, the ring body, the boss and the intraocular lens are all made of biocompatible materials; no polymerizable dye is added or added to the biocompatible materials; the biocompatible materials The materials are silica gel, polymethyl methacrylate, hydrophobic acrylate or cross-linked polyolefin materials.

Further, the intraocular lens includes an optical surface and a loop; the optical surface of the intraocular lens is any one of a spherical surface, an aspheric surface, astigmatism or a multifocal optical surface, and the intraocular lens has two or more loops.

Furthermore, during use, according to the patient's condition, the adjustable intracapsular ring and the intraocular lens are implanted in the same operation.

Furthermore, during use, according to the patient's condition, the adjustable intracapsular ring and the intraocular lens are implanted separately in multiple operations.

(3) Positive effects of the present invention:

The invention relates to a comprehensive intraocular lens implant for congenital cataracts, including an adjustable intracapsular ring and an intraocular lens arranged on the adjustable intracapsular ring. The adjustable intracapsular ring is a specially designed intraocular lens The ring, which has a certain thickness, shape and elasticity, can maintain the contour and elasticity of the pediatric capsular bag after the cataract is removed, and prevent the capsular bag from being severely contracted due to the absence of natural crystals. The intracapsular ring can not only produce corresponding size changes with the growth of the pediatric capsular bag, but also prevent the migration of epithelial cells. More importantly, the structure of the adjustable intracapsular ring is specially designed to accept the intraocular lens implanted later. The adjustable intracapsular ring is used in the capsular bag to provide convenience for the second implantation of the intraocular lens. It is no longer necessary to put the loop of the intraocular lens into the ciliary sulcus, which greatly reduces the stimulation to the ciliary sulcus and reduces the possibility of pigmentation and glaucoma. The intraocular lens placed on the adjustable intracapsular ring is used in conjunction with the adjustable intracapsular ring. It consists of an optical part and a loop part. The optical part can be any spherical, aspheric or multifocal intraocular lens. The design of the loop can be The intraocular lens can be placed on the inner ring of the capsule, and the intraocular lens can be fixed in the center. It is possible to add through holes or/and blind holes on the inner ring of the capsule for placing sustained-release drugs to effectively reduce and control postoperative inflammation.

For pediatric patients with integrated intraocular lens implants, after the growth period, the intraocular lens placed on the adjustable intracapsular ring can be replaced according to the needs of the patient, and it can also be added to the adjustable intracapsular ring An intraocular lens is used to change the diopter, because the adjustable intracapsular ring also reserves a place for the second artificial lens. The above methods can effectively solve the problem of continuous diopter changes in adolescent cataract patients.

Description of the drawings

FIG. 1 is a schematic diagram of the structure of the adjustable intracapsular ring described in Example 3;

2 is a schematic diagram of the structure of the adjustable intracapsular ring described in Example 4;

3 is a schematic diagram of the structure of the adjustable inner ring of the capsule according to the embodiment 5;

4 is a schematic diagram of the structure of the adjustable intracapsular ring described in Example 6;

Fig. 5 is a schematic structural diagram of the adjustable intra-capsular ring of embodiment 7;

6 is a schematic diagram of the structure of the adjustable inner ring of the capsule in Example 8;

FIG. 7 is a schematic diagram of the structure of the adjustable inner ring of the capsule according to the embodiment 9;

FIG. 8 is a schematic diagram of the structure of the adjustable inner ring of the capsule according to the embodiment 10; FIG.

Fig. 9 is a partial enlarged view of a concave arc structure on the outer side of the ring body;

Fig. 10 is a partial enlarged view of a convex arc structure on the outer side of the ring body;

11 is a partial enlarged view of the cross-sectional shape of the ring-shaped main body being a trapezoid;

FIG. 12 is a schematic diagram of the structure of the adjustable intracapsular ring of embodiment 17;

13 is a schematic diagram of the structure of the adjustable intracapsular ring of embodiment 18;

14 is a schematic diagram of the structure of the adjustable intra-capsular ring described in Example 19;

15 is a schematic diagram of the structure of the adjustable intracapsular ring of embodiment 20;

FIG. 16 is a schematic diagram of the structure of the adjustable intracapsular ring of embodiment 21;

17 is a schematic diagram of the structure of the adjustable intra-capsular ring of embodiment 22;

Figure 18 is a schematic diagram of the meaning designation of the front side, the back side and the inner side of the ring body and the boss;

19 is a schematic diagram of the structure of the integrated intraocular lens implant for congenital cataract described in Example 26;

20 is a schematic diagram of the structure of the integrated intraocular lens implant for congenital cataract described in Example 27;

21 is a schematic diagram of the structure of the integrated intraocular lens implant for congenital cataract described in Example 28;

In the figure, 1 ring body, 11 arc structure, 12 connecting part, 13 second through hole, 2 boss, 21 notch groove, 22 first through hole, 23 blind hole, H1 thickness of ring body, H2 convex The thickness of the platform, the front side of the A1 ring body, the back side of the B1 ring body, the inner side of the C1 ring body, the outer side of the D1 ring body, the front side of the A2 boss, the back side of the B2 boss, The inner side of the C2 boss.

Detailed ways

The present invention will be further described below in conjunction with the embodiments.

The integrated intraocular lens implant for congenital cataracts of the present invention includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100. The adjustable intracapsular ring 100 includes a ring A shaped body 1 and a boss 2 for assembling an intraocular lens. The annular body 1, the boss 2, and the intraocular lens 200 of the adjustable intracapsular ring 100 are all made of biocompatible materials; the biocompatible materials may not be added or added with polymerizable dyes. When dyes of different colors are added, the manufactured adjustable intracapsular ring 100 presents different colors, so that the intracapsular ring can be clearly distinguished during surgical implantation. The material with biocompatibility can be silica gel, polymethyl methacrylate, hydrophobic acrylate, and cross-linked polyolefin material. The sustained-release medicine mentioned in the present invention can effectively reduce and control postoperative inflammation. In addition, the shape of the first through hole 22, the second through hole 13 and the blind hole 23 of the present invention may be other shapes in addition to the shapes listed in this specification, as long as the functions described in the present invention can be realized.

(1) Different types of adjustable intracapsular rings

Example 1

The adjustable intracapsular ring of this embodiment includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens. The boss 2 is provided on the inner side of the ring body 1. When the adjustable intracapsular ring is implanted After the capsular bag, the outer circumference of the ring body 1 can be in contact with the inner surface of the capsular bag, the boss 2 is located at the lower part of the thickness of the ring body 1, the thickness H1 of the ring body 1 is greater than the thickness H2 of the boss 2, the boss The front side of 2 is lower than the front side of the ring body 1, and the rear side of the boss 2 is higher than the back side of the ring body 1. The ring body 1 is a closed-loop structure, and the ring body 1 consists of two or two sections The above arc structure 11 is connected by a connecting portion 12, the connecting portion 12 is a V-shaped or U-shaped structure, the opening of the V-shaped or U-shaped structure faces outward, and the ring-shaped body 1 and the boss 2 are One-piece structure.

Example 2

The adjustable intracapsular ring of this embodiment includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens. The boss 2 is provided on the inner surface of the ring body 1. When the adjustable intracapsular ring is implanted After the capsular bag, the outer circumference of the ring body 1 can contact the inner surface of the capsular bag, the boss 2 is located at the upper part of the thickness of the ring body 1, the thickness H1 of the ring body 1 is greater than the thickness H2 of the boss 2, the boss The front side of 2 is lower than the front side of the ring body 1, and the rear side of the boss 2 is higher than the back side of the ring body 1. The ring body 1 has a C-shaped open-loop structure, and the ring body 1 is a section of circle. The arc structure 11 is formed, and the ring-shaped body 1 and the boss 2 are integrally formed.

Example 3

The adjustable intracapsular ring described in this embodiment is shown in Fig. 1, and includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens. The ring-shaped body 1 and the boss 2 are an integral structure. The main body 1 has a C-shaped open-loop structure, the boss 2 is provided on the inner side of the ring-shaped main body 1, and the ring-shaped main body 1 is composed of a section of arc structure 11, and the inner side of the ring-shaped main body 1 is provided with two protrusions. A notch 21 is provided between the two bosses 2. The thickness H1 of the ring body 1 is greater than the thickness H2 of the boss 2. The boss 2 is located in the middle of the thickness of the ring body 1, and the front side of the boss 2 is low On the front side of the ring body 1, the back side of the boss 2 is higher than the back side of the ring body 1. After the adjustable inner ring of the capsule is implanted in the capsule, the outer circumference of the annular body 1 can contact the inner surface of the capsule. In this embodiment, the outer surface of the ring-shaped body 1 is a plane structure, the cross-sectional shape of the ring-shaped body 1 is a rectangle, and the cross-sectional shape of the boss 2 is a rectangle.

Example 4

The adjustable intracapsular ring described in this embodiment is shown in Fig. 2. It includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens. The ring-shaped body 1 and the boss 2 are integrally formed. The main body 1 has a closed-loop structure. The boss 2 is provided on the inner side of the ring-shaped main body 1. The ring-shaped main body 1 is formed by connecting two arc structures 11 through a connecting portion 12, and the connecting portion 12 is a V-shaped structure. The opening of the V-shaped structure faces outward, the inner side of the ring-shaped body 1 is provided with two bosses 2, and a gap groove 21 is provided between the two bosses 2, and the thickness H1 of the ring-shaped body 1 is greater than that of the bosses. The thickness of the boss 2 is H2, the boss 2 is located in the middle of the thickness of the ring body 1, the front side of the boss 2 is lower than the front side of the ring body 1, and the back side of the boss 2 is higher than the back side of the ring body 1. The boss 2 is provided with a first through hole 22; the first through hole 22 is a waist-shaped through hole, and the first through hole 22 is used to ensure the flow of front and back aqueous humor or to place a slow-release drug . After the adjustable inner ring of the capsule is implanted in the capsule, the outer circumference of the annular body 1 can contact the inner surface of the capsule. In this embodiment, the cross-sectional shape of the annular body 1 is rectangular, and the cross-sectional shape of the boss 2 is rectangular.

Example 5

The adjustable intracapsular ring described in this embodiment is shown in Fig. 3, and includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens. The ring-shaped body 1 and the boss 2 are integrally formed. The main body 1 has a C-shaped open-loop structure, the boss 2 is provided on the inner side of the ring-shaped main body 1, and the ring-shaped main body 1 is composed of a section of arc structure 11, and the inner side of the ring-shaped main body 1 is provided with two protrusions. A notch 21 is provided between the two bosses 2. The thickness H1 of the ring body 1 is greater than the thickness H2 of the boss 2. The boss 2 is located in the middle of the thickness of the ring body 1, and the front side of the boss 2 is low On the front side of the ring body 1, the back side of the boss 2 is higher than the back side of the ring body 1. The boss 2 is provided with a first through hole 22; the first through hole 22 is a circular through hole, and the annular body 1 is provided with a second through hole 13, and the second through hole 13 It is a circular through hole, and the first through hole 22 and the second through hole 13 are used to ensure the flow of aqueous humor before and after or to place a slow-release drug. After the adjustable inner ring of the capsule is implanted in the capsule, the outer circumference of the annular body 1 can contact the inner surface of the capsule. In this embodiment, the cross-sectional shape of the annular body 1 is rectangular, and the cross-sectional shape of the boss 2 is rectangular.

Example 6

The adjustable intracapsular ring described in this embodiment is shown in Fig. 4, and includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens. The ring-shaped body 1 and the boss 2 are an integral structure. The main body 1 has a C-shaped open-loop structure, and the boss 2 is provided on the inner side of the ring-shaped main body 1. The arc shape of the boss 2 is different from that of the embodiment 3. The ring-shaped main body 1 is composed of a circular arc structure 11, The inner side of the ring-shaped body 1 is provided with two bosses 2, and a gap groove 21 is provided between the two bosses 2. The thickness H1 of the ring-shaped body 1 is greater than the thickness H2 of the bosses 2, and the bosses 2 are located in the ring In the middle of the thickness of the main body 1, the front side of the boss 2 is lower than the front side of the ring body 1, and the back side of the boss 2 is higher than the back side of the ring body 1. The boss 2 is provided with a first through hole 22; the first through hole 22 is a waist-shaped through hole, and the first through hole 22 is used to ensure the flow of front and back aqueous humor or to place a slow-release drug . After the adjustable inner ring of the capsule is implanted in the capsule, the outer circumference of the annular body 1 can contact the inner surface of the capsule. In this embodiment, the cross-sectional shape of the ring-shaped body 1 is rectangular.

Example 7

The adjustable bladder inner ring of this embodiment is shown in Fig. 5. The difference from embodiment 6 is that a second through hole 13 is provided on the annular body 1, and the second through hole 13 is circular Through holes, the second through holes 13 are used to ensure the flow of aqueous humor before and after or to place slow-release drugs. The remaining features are the same as those described in Example 6.

Example 8

The adjustable intracapsular ring of this embodiment is shown in Fig. 6, and includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens. The ring-shaped body 1 and the boss 2 are an integral structure. The main body 1 has a closed-loop structure. The boss 2 is provided on the inner side of the ring-shaped main body 1. The ring-shaped main body 1 is formed by connecting two arc structures 11 through a connecting portion 12, and the connecting portion 12 is a U-shaped structure. The opening of the U-shaped structure faces outward, and two bosses 2 are provided on the inner side of the ring-shaped body 1. The arc shape of the bosses 2 is different from that of the third embodiment, and a notch groove is provided between the two bosses 2 21. The thickness H1 of the ring body 1 is greater than the thickness H2 of the boss 2. The boss 2 is located in the middle of the thickness of the ring body 1. The front side of the boss 2 is lower than the front side of the ring body 1, and the back of the boss 2 The side surface is higher than the rear side surface of the ring body 1. After the adjustable inner ring of the capsule is implanted in the capsule, the outer circumference of the annular body 1 can contact the inner surface of the capsule. In this embodiment, the cross-sectional shape of the annular body 1 is rectangular, and the cross-sectional shape of the boss 2 is rectangular.

Example 9

The adjustable bladder inner ring of this embodiment is shown in Fig. 7. The difference from embodiment 8 is that the boss 2 is provided with a first through hole 22; the first through hole 22 is a circular through hole. Hole, the ring-shaped body 1 is provided with a second through hole 13, the second through hole 13 is a circular through hole, the first through hole 22 and the second through hole 13 are used to ensure the front and rear aqueous humor It can be used to place slow-release drugs to effectively ensure the flow of aqueous humor before and after. The remaining features are the same as those described in Example 8.

Example 10

The adjustable bladder inner ring of this embodiment is shown in Fig. 8. The difference from embodiment 4 is that a second through hole 13 is provided on the annular body 1, and the second through hole 13 is circular Through holes, the second through holes 13 are used to ensure the flow of aqueous humor before and after or to place slow-release drugs. The remaining features are the same as those described in Example 4.

Example 11

The adjustable inner bag ring of this embodiment is different from the embodiment 4 in that the ring-shaped body 1 is provided with a second through hole 13, and the second through hole 13 is a waist-shaped through hole, which is effective Ensure the flow of aqueous humor before and after. The remaining features are the same as those described in Example 4.

Example 12

The adjustable bladder ring of this embodiment is different from the embodiment 4 in that the ring body 1 is provided with a second through hole 13, and the second through hole 13 is a polygonal through hole, which effectively guarantees The flow of aqueous humor before and after. The remaining features are the same as those described in Example 4.

Example 13

The adjustable bladder inner ring of this embodiment is different from the embodiment 8 in that the boss 2 is provided with a first through hole 22; the first through hole 22 is a polygonal through hole, which effectively guarantees the front and rear The flow of aqueous humor. The remaining features are the same as those described in Example 8.

Example 14

The adjustable inner balloon ring of this embodiment is different from the embodiment 4 in that the outer surface of the ring body 1 is a concave arc structure, as shown in Fig. 9 a partial enlarged view. The remaining features are the same as those described in Example 4.

Example 15

The adjustable inner balloon ring of this embodiment is different from the embodiment 4 in that the outer surface of the ring body 1 is a convex arc structure, as shown in Fig. 10, a partial enlarged view. The remaining features are the same as those described in Example 4.

Example 16

The adjustable inner balloon ring of this embodiment is different from the third embodiment in that the cross-sectional shape of the annular body 1 is a trapezoid, as shown in FIG. 11, a partial enlarged view, and the cross-sectional shape of the boss 2 is a trapezoid. The remaining features are the same as those described in Example 4.

Example 17

The adjustable inner ring of the capsule in this embodiment is shown in Fig. 12. The difference from embodiment 4 is that the front side of the boss 2 is also provided with a blind hole 23 for placing a slow-release drug. It is circular, the inner surface of the boss 2 is provided with a blind hole 23 for placing slow-release drugs, the blind hole is a waist-shaped groove, and the front side of the ring-shaped body 1 is also provided with a blind hole 23 for placing the slow-release drug. The blind hole 23 of the medicine, the blind hole is circular. The remaining features are the same as those described in Example 4.

Example 18

The adjustable bladder inner ring of this embodiment is shown in Fig. 13. The difference from the embodiment 17 is that the outer surface of the ring body 1 is a concave arc structure. The remaining features are the same as those described in Example 17.

Example 19

The adjustable balloon inner ring of this embodiment is shown in Fig. 14. The difference from embodiment 10 is that the outer surface of the ring body 1 is a convex arc structure; the front side of the boss 2 A blind hole 23 for placing a slow-release drug is also provided, the blind hole is circular, the inner side of the boss 2 is provided with a blind hole 23 for placing a slow-release drug, and the blind hole is a waist-shaped groove. The remaining features are the same as those described in Example 10.

Example 20

The adjustable balloon inner ring of this embodiment is shown in Fig. 15. The difference from embodiment 3 is that the outer surface of the ring body 1 is a concave arc structure; the inner surface of the boss 2 is provided There is a blind hole 23 for placing sustained-release drugs, and the blind hole is a waist-shaped groove. The remaining features are the same as those described in Example 3.

Example 21

The adjustable sac inner ring of this embodiment is shown in Fig. 16. The difference from embodiment 6 is that the front side of the boss 2 is also provided with a blind hole 23 for placing a slow-release drug. In the shape of a circle, the inner surface of the boss 2 is provided with a blind hole 23 for placing sustained-release drugs, the blind hole is a waist-shaped groove, and the ring-shaped body 1 is provided with a second through hole 13, the The second through hole 13 is a circular through hole, and the second through hole 13 is used to ensure the flow of aqueous humor or to place slow-release drugs. The outer surface of the ring body 1 is a convex arc structure. The remaining features are the same as those described in Example 6.

Example 22

The adjustable intracapsular ring of this embodiment is shown in Fig. 17, and includes a ring-shaped body 1 and a boss 2 for assembling an intraocular lens. The ring-shaped body 1 and the boss 2 are an integral structure. The main body 1 has a closed-loop structure. The boss 2 is provided on the inner side of the ring-shaped main body 1. The ring-shaped main body 1 is formed by connecting two arc structures 11 through a connecting portion 12, and the connecting portion 12 is a V-shaped structure. The opening of the V-shaped structure faces outward, and the thickness of the connecting portion 12 is the same as the thickness of the annular body 1. The inner side of the ring-shaped body 1 is provided with two bosses 2, and a gap groove 21 is provided between the two bosses 2. The thickness H1 of the ring-shaped body 1 is greater than the thickness H2 of the bosses 2, and the bosses 2 are located in the ring At the lower part of the thickness of the shaped body 1, the front side of the boss 2 is lower than the front side of the ring body 1, and the back side of the boss 2 and the back side of the ring body 1 are on the same plane. The boss 2 is provided with a first through hole 22; the first through hole 22 is a waist-shaped through hole, and the first through hole 22 is used to ensure the flow of front and back aqueous humor or to place a slow-release drug . After the adjustable inner ring of the capsule is implanted in the capsule, the outer circumference of the annular body 1 can contact the inner surface of the capsule.

Example 23

The adjustable inner ring of the capsule in this embodiment is shown in Fig. 18. The difference from the embodiment 10 is that the front side of the boss 2 is also provided with a blind hole 23 for placing a slow-release drug. In a circular shape, the inner surface of the boss 2 is provided with a blind hole 23 for placing a slow-release drug, the blind hole is a waist-shaped groove, and the outer surface of the ring body 1 has a concave arc structure. The remaining features are the same as those described in Example 10.

(2) Assembly example of integrated intraocular lens implant for congenital cataract

Example 24

The integrated intraocular lens implant for congenital cataracts described in this embodiment includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100; the adjustable intracapsular ring 100 includes a ring A shaped body 1 and a boss 2 for assembling an intraocular lens. The boss 2 is arranged on the inner side of the ring-shaped body 1. The ring-shaped body 1 has a closed-loop structure. When the adjustable intracapsular ring is implanted in the capsular bag , The outer circumference of the ring body 1 can be in contact with the inner surface of the capsular bag.

Example 25

The integrated intraocular lens implant for congenital cataracts described in this embodiment includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100; the adjustable intracapsular ring 100 includes a ring A shaped body 1 and a boss 2 for assembling an intraocular lens. The boss 2 is arranged on the inner surface of the ring body 1. The ring body 1 has a C-shaped open ring structure. When the adjustable intracapsular ring is implanted After the capsular bag, the outer circumference of the ring-shaped body 1 can contact the inner surface of the capsular bag.

Example 26

The integrated intraocular lens implant for congenital cataract described in this embodiment is shown in Fig. 19, which includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100; The ring 100 includes a ring body 1 and a boss 2 for assembling an intraocular lens. The boss 2 is arranged on the inner surface of the ring body 1. The ring body 1 has a C-shaped open ring structure. After the inner ring is implanted in the capsular bag, the outer circumference of the annular body 1 can contact the inner surface of the capsular bag.

In this embodiment, two different types of intraocular lenses 200 are assembled on the front side of the boss 2 and the back side of the boss 2 of the adjustable intracapsular ring 100. The optical surface of the intraocular lens 200 can be spherical, aspherical, astigmatic or multi-faceted. There are two haptics of the intraocular lens 200 for any one of the optical surfaces such as the focal point.

The difference between the adjustable inner balloon ring 100 used in this embodiment and the adjustable inner balloon ring 100 described in Example 6 is that the upper surface of the boss 2 is also provided with a blind hole 23, and the boss 2 A blind hole 23 is provided on the inner side of the ring, and a blind hole 23 is also provided on the ring-shaped body 1. The blind hole 23 is used for placing sustained-release drugs. The remaining features are the same as those described in Example 6.

Example 27

The integrated intraocular lens implant for congenital cataract described in this embodiment is shown in Fig. 20, which includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100; the adjustable intracapsular The ring 100 includes a ring body 1 and a boss 2 for assembling an intraocular lens. The boss 2 is arranged on the inner side of the ring body 1. The ring body 1 is a closed ring structure. After being inserted into the capsular bag, the outer circumference of the annular body 1 can be in contact with the inner surface of the capsular bag.

In this embodiment, an intraocular lens 200 is assembled on the front side of the boss 2 of the adjustable intracapsular ring 100. The optical surface of the intraocular lens 200 can be any one of spherical, aspherical, astigmatic or multifocal optical surfaces. The intraocular lens There are 2 loops of 200.

The adjustable inner bag ring 100 used in this embodiment is different from the embodiment 9 in that the inner surface of the boss 2 is provided with a blind hole 23. The blind hole 23 is used for placing sustained-release drugs. The remaining features are the same as those described in Example 9.

Example 28

The integrated intraocular lens implant for congenital cataract described in this embodiment is shown in Fig. 21. It includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100; The ring 100 includes a ring body 1 and a boss 2 for assembling an intraocular lens. The boss 2 is arranged on the inner surface of the ring body 1. The ring body 1 has a C-shaped open ring structure. After the inner ring is implanted in the capsular bag, the outer circumference of the annular body 1 can contact the inner surface of the capsular bag.

In this embodiment, an intraocular lens 200 is assembled on the back side of the boss 2 of the adjustable intracapsular ring 100. The optical surface of the intraocular lens 200 can be any one of spherical, aspherical, astigmatic or multifocal optical surfaces. The intraocular lens There are 2 loops of 200.

The adjustable inner balloon ring 100 used in this embodiment is the adjustable inner balloon ring 100 described in Embodiment 21.

The method of using the integrated intraocular lens implant for congenital cataracts of the present invention:

(1) First, phacoemulsification is used to remove the cloudy natural lens of the cataract patient, and then select the adjustable intracapsular ring 100 suitable for the size of the patient's capsular bag, and slowly push the intracapsular ring into the patient with tweezers or a special intracapsular injection device. Inside the bag, and adjust the position of the adjustable inner ring 100;

(2) According to the actual situation of the patient, an intraocular lens 200 can be placed on the front or back side of the boss 2 of the adjustable intracapsular ring 100 when appropriate. The intraocular lens 200 placed on the adjustable intracapsular ring 100 can be replaced at an appropriate time according to the needs of the patient, or another intraocular lens 200 can be added to the intracapsular ring to change the diopter.

The manufacturing method of the integrated intraocular lens implant for congenital cataract of the present invention:

Adjustable inner sac ring 100: It is injection molded into a blank, processed by mechanical processing, and then subjected to post-processing such as grinding, polishing, cleaning, and drying. After that, it is packaged and sterilized, and it is implanted into the human eye sac through a special injection device or tweezers. Inside.

Intraocular lens 200: After injection molding, the blank is mechanically processed, and then chemical treatment, cleaning, drying and other post-treatments are carried out, and then packaged and sterilized. After the intraocular lens bolus is implanted in the human eye capsule, it is placed in the capsule One side of the inner ring. The intraocular lens 200 of the present invention may be an intraocular lens in the prior art or a new type of intraocular lens developed in the future. As long as it can be assembled on the boss 2 of the adjustable intracapsular ring 100 of the present invention, it is protected by the present invention. Design concept.

The innovation of the present invention:

(1) The integrated intraocular lens implant for congenital cataracts of the present invention includes an adjustable intracapsular ring 100 and an intraocular lens 200 assembled on the adjustable intracapsular ring 100. The adjustable intracapsular ring 100 An intraocular lens 200 can be mounted on it. According to the actual situation of the patient, place an intraocular lens 200 on the anterior or posterior side of the boss 2 of the adjustable intracapsular ring 100. The intraocular lens can also be replaced according to the needs of the patient, and another intraocular lens can be added to the boss 2 200 to adjust the diopter of the patient. The combined implants can be implanted separately. When cataracts are removed, the adjustable intracapsular ring 100 is first implanted to protect the pediatric capsular bag. When appropriate, the intraocular lens 200 can be implanted in the adjustable intracapsular ring 100. As a secondary implant. The adjustable intracapsular ring 100 and the intraocular lens 200 can also be implanted in one operation.

(2) The unique structural design of the adjustable intracapsular ring 100 of the present invention enables the intracapsular ring to produce corresponding size changes with the growth of the pediatric capsular bag, maintain the circular contour of the capsular bag, and help maintain the normal lens capsular bag Physiological position to prevent tilt and eccentricity of the intraocular lens.

(3) Since the intraocular lens is in contact with the inner surface of the adjustable intracapsular ring instead of the capsular bag, it reduces the surgical difficulty that the intraocular lens may adhere to the capsular bag and is not easy to remove.

(4) When the adjustable intracapsular ring is implanted in the capsular bag, the outer circumference of the ring body 1 can contact the inner surface of the capsular bag, which can play a barrier function and contact inhibition effect, prevent the proliferation and migration of lens epithelial cells, and reduce After the occurrence of cataract, to prevent the occurrence of turbidity of the capsule before and after.

(5) The boss 2 is provided with a first through hole 22; the first through hole 22 is a waist-shaped, polygonal or circular through hole, and the first through hole 22 is used to ensure the front and back of the aqueous humor It is mobile or used to place sustained-release drugs. The annular body 1 is provided with a second through hole 13; the second through hole 13 is a waist-shaped, polygonal, or circular through hole, and the second through hole 13 is used to ensure the flow or use of aqueous humor before and after. Place sustained-release drugs.

(6) The annular body 1 and/or the boss 2 are provided with a blind hole 23 for placing a slow-release drug, and the blind hole is waist-shaped, polygonal or circular.

(7) The ring-shaped body 1 and the boss 2 are made of biocompatible materials; the biocompatible materials may not be added or added with polymerizable dyes, and when necessary, they may have biological phases. When the polymerizable dye is added to the capacitive material, the adjustable intracapsular ring of the present invention presents different colors, which is convenient for making the intracapsular ring clearly distinguishable during surgical implantation.

The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be considered that the specific implementation of the present invention is limited to these descriptions. For those of ordinary skill in the art to which the present invention belongs, several simple deductions or substitutions can be made without departing from the concept of the present invention, which should be regarded as belonging to the protection scope of the present invention.

Claims

A comprehensive intraocular lens implant for congenital cataract, which is characterized in that it comprises an adjustable intracapsular ring (100) and an intraocular lens (200) assembled on the adjustable intracapsular ring (100); The adjustable intracapsular ring (100) includes a ring-shaped body (1) and a boss (2) for assembling the intraocular lens. The boss (2) is arranged on the inner side of the ring-shaped body (1). The main body (1) has a closed-loop structure or a C-shaped open-loop structure. After the adjustable intra-capsular ring is implanted in the capsular bag, the outer circumference of the annular main body (1) can be in contact with the inner surface of the capsular bag.
The integrated intraocular lens implant for congenital cataracts according to claim 1, wherein the adjustable intracapsular ring (100) is equipped with one intraocular lens (200) or two intraocular lenses (200).
The integrated intraocular lens implant for congenital cataracts according to claim 1, characterized in that: the intraocular lens (200) is assembled on the front side of the boss (2) and/or the back of the boss (2) On the side.
The integrated intraocular lens implant for congenital cataracts according to claim 1, characterized in that: when the ring-shaped body (1) has a C-shaped open ring structure, the ring-shaped body (1) has a circular arc structure ( ( 12) It is a V-shaped or U-shaped structure, and the opening of the V-shaped or U-shaped structure faces outward.
The integrated intraocular lens implant for congenital cataracts according to claim 1, characterized in that: the annular body (1) is provided with a plurality of bosses (2), two adjacent bosses (2) A gap groove (21) is arranged between ); the thickness (H1) of the annular body (1) is greater than the thickness (H2) of the boss (2).
The integrated intraocular lens implant for congenital cataracts according to claim 1, characterized in that the ring-shaped body (1) and the boss (2) are integrally formed.
The integrated intraocular lens implant for congenital cataracts according to claim 1, characterized in that: the outer surface of the ring-shaped body (1) is a plane structure, a concave arc structure or a convex arc Structure; the cross-sectional shape of the boss (2) is rectangular or trapezoidal.
The integrated intraocular lens implant for congenital cataracts according to claim 1, characterized in that: the boss (2) is provided with a first through hole (22); the first through hole (22) It is a waist-shaped, polygonal or circular through hole, and the first through hole (22) is used to ensure the flow of aqueous humor before and after or to place a slow-release drug.
The integrated intraocular lens implant for congenital cataracts according to claim 1, characterized in that: the annular body (1) is provided with a second through hole (13); the second through hole (13) It is a waist-shaped, polygonal or circular through hole, and the second through hole (13) is used to ensure the flow of front and back aqueous humor or to place slow-release drugs.
The integrated intraocular lens implant for congenital cataracts according to claim 1, characterized in that: the annular body (1) and/or the boss (2) is provided with a blind hole ( 23) The blind hole is waist-shaped, polygonal or circular.
The integrated intraocular lens implant for congenital cataracts according to claim 1, characterized in that: the annular body (1), the boss (2) and the intraocular lens (200) are all made of biocompatible The material with biocompatibility is not added or added with polymerizable dye; the material with biocompatibility is silica gel, polymethyl methacrylate, hydrophobic acrylate or cross-linked polymer Olefin material.
The integrated intraocular lens implant for congenital cataracts according to claim 1, characterized in that: the intraocular lens (200) includes an optical surface and a loop; the optical surface of the intraocular lens (200) is spherical, non-spherical Any one of spherical surface, astigmatism or multifocal optical surface, the number of loops of the intraocular lens (200) is 2 or more.
The integrated intraocular lens implant for congenital cataracts according to claim 1, characterized in that: during use, according to the patient's condition, the adjustable intracapsular ring (100) and the intraocular lens (200) are at the same time Implanted during surgery.
The integrated intraocular lens implant for congenital cataract according to claim 1, characterized in that: during use, according to the patient's condition, the adjustable intracapsular ring (100) and the intraocular lens (200) are used for multiple times They were implanted separately during the operation.