WO2019094768A1 - Lentille intraoculaire - Google Patents

Lentille intraoculaire Download PDF

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Publication number
WO2019094768A1
WO2019094768A1 PCT/US2018/060095 US2018060095W WO2019094768A1 WO 2019094768 A1 WO2019094768 A1 WO 2019094768A1 US 2018060095 W US2018060095 W US 2018060095W WO 2019094768 A1 WO2019094768 A1 WO 2019094768A1
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WO
WIPO (PCT)
Prior art keywords
haptic
lens
ocular implant
refractive
eye
Prior art date
Application number
PCT/US2018/060095
Other languages
English (en)
Inventor
Manus KRAFF
Original Assignee
Kraff Manus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kraff Manus filed Critical Kraff Manus
Publication of WO2019094768A1 publication Critical patent/WO2019094768A1/fr

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1602Corrective lenses for use in addition to the natural lenses of the eyes or for pseudo-phakic eyes
    • A61F2/1605Anterior chamber lenses for use in addition to the natural lenses of the eyes, e.g. iris fixated, iris floating
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A61B3/125Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes with contact lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2/1602Corrective lenses for use in addition to the natural lenses of the eyes or for pseudo-phakic eyes
    • A61F2/161Posterior chamber lenses for use in addition to the natural lenses of the eyes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/14Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16Intraocular lenses
    • A61F2002/1681Intraocular lenses having supporting structure for lens, e.g. haptics

Definitions

  • the present disclosure relates generally to a refractive intraocular implant for placement in either the anterior or posterior chamber of an eye.
  • the present disclosure is further directed to a method for treating refractive errors in a patient by anchoring the intraocular lens into the anterior or posterior chamber of the eye.
  • Intraocular implants for the posterior chamber have been designed to treat myopia (nearsightedness), astigmatism, and hyperopia (farsightedness), but are predominantly designed to replace a previously or simultaneously removed crystalline lens (aphakic eye) in a cataract patient.
  • Intraocular lenses are surgically implanted into the aphakic eye in order to take the place of the previously or simultaneously removed natural crystalline lens. These intraocular lenses are implanted into the posterior chamber of the eye to compensate for refractive errors or to create a specific refraction to assist in visual function. Anterior chamber lenses are also available for complicated cases.
  • the anterior chamber of an eye is an area in front of the iris and behind the cornea.
  • the iris acts as a divider between the anterior chamber and the posterior chamber with the iris constricting and expanding an aperture (pupil) to affect the amount of light captured by the eye.
  • Intraocular lenses have not been predominately designed for the phakic eye (crystalline lens not removed) in the anterior chamber of eye as certain difficulties have been associated with implanting in the phakic eye. Such difficulties include the fact that the phakic eye is a substantially more reactive environment than the aphakic eye. Inflammatory reactions tend to be greater in the anterior chamber of the phakic eye. Such damage may include uveitis hyphemia glaucoma (UGH) syndrome, cataracts, pain, corneal edema, progressive endothelial cell loss, and discomfort.
  • UDH uveitis hyphemia glaucoma
  • Some of these effects may be due to poor lens design or may be due to the presence of the natural crystalline lens in the phakic eye crowding the anterior chamber.
  • the phakic eye has a shallower anterior chamber than the aphakic eye, and the iris is in broad posterior contact with the natural crystalline lens. Therefore, if an inflammatory reaction occurs in the phakic eye, there can be adherence of the iris to an anterior surface of the intraocular lens.
  • intraocular lens of the present disclosure may be appropriate for implantations of a primary lens to be used after cataract extraction for optical correction of the eye.
  • the disclosed intraocular lens has at least three angled fixation haptics that support any type of optic body including a negative, positive, astigmatic, or multifocal power lens to correct refractive errors resulting from conditions such as myopia, hyperopia, presbyopia, astigmatism or previous surgery.
  • the haptic design precludes necrosis of angle tissue and does not distort the iris's architecture.
  • the disclosed intraocular lens includes a refractive lens having a front surface and a back surface, and at least three haptics for positioning into the anatomic or iridocorneal angle of the eye.
  • the distal end of each haptic includes a contact pad for engaging the anatomic angle, the width or radius of the contact pad being greater than that of the haptic.
  • the haptic is curved in both a horizontal and vertical direction, such that the haptic slopes downward in a curved or spiral shape.
  • three haptics are positioned away from the lens such that the center of each contact pad at the distal end of each haptic forms an end to an imaginary equilateral triangle.
  • the refractive ocular lens is centered on the eye.
  • the sloped nature of the haptics ensures that the refractive lens is suspended over the eye, creating a vault between the eye and the refractive lens.
  • the vertical and horizontal curvature of the haptics, as well as the positioning of the contact pads provides both columnar and cantilever support, ensuring that the refractive lens will not rotate in the eye, even when external pressure is applied.
  • the refractive lens is supported by the anatomic angle, it does not require sutures to anchor the lens to the eye, and therefore is easier to implant as well as extract (if needed).
  • the large footprint of the contact pads ensures that that the contact pads do not adhere to the anatomic angle structures, thus avoiding intraocular damage.
  • Fig. 1 is a front view of an anterior chamber intraocular lens according to an embodiment.
  • Fig. 2 is a side view of the anterior chamber intraocular lens of Fig. 1.
  • Fig. 3A is a cross section view of the intraocular lens of Fig. 1 in use in a phakic eye.
  • Fig. 3B is a cross section view of the intraocular lens of Fig. 1 in use with an aphakic eye.
  • Fig. 4 is a front view of an intraocular lens according to a second embodiment.
  • Fig. 5 is a front view of an intraocular lens according to a third embodiment.
  • a refractive anterior chamber ocular implant 1 having three haptics 11, 11 ', 11" being integral or attached to the refracting lens 14.
  • the lens 14 When implanted into the anterior chamber 16 of a phakic eye 18, the lens 14 is positioned and maintained by the haptics 1 1, 11 ', 11" to prevent contact between it and other anatomical bodies such as the anatomical crystalline lens or other intraocular implant 20, the iris 22, and the corneal endothelium 24 (Fig. 3A).
  • the optic lens 14 is in a plane perpendicular to the optic axis 4 of the eye 18, and the three points of contact B, C, D of the haptic 11, 11 ', 11" are distributed on the circumference of the iridocorneal or anatomic angle 31. More particularly, the ends 26, 26', 26" of the respective haptics 11, 11 ', 11" may be configured to situate within the iris plane or angle 31 to prevent irritation of consequential anterior synechia formation, fibrosis and anisocoria.
  • the implant 1 may be implanted into an individual that either has no crystalline lens 20 or pseudophake (surgically implanted lens to replace crystalline lens), as both the lens and capsule may have been removed, such as through a surgery, i.e. intracapsular cataract extraction (ICCE).
  • ICCE intracapsular cataract extraction
  • the intraocular lens 1 is shown in Fig. 3B in use positioned within the capsular bay (aperture left from crystalline lens removal) of the posterior chamber or posterior chamber configuration.
  • the lens 14 may be concave, convex, aspheric, multi-order diffractive, planar, or any combination thereof, in order to achieve the desired degree of corrective refraction.
  • the optical portion of lens 14, may be fabricated from compounds such as silicone polymer, HEMA, acrylic, polymethylmethacrylate (PMMA), polyimide, hydrogel (formed from a certain percentage of water).
  • the artificial refracting lens 14 of the present invention may be foldable (elastic), rigid, or a combination, depending upon the particular selected composition of the lens.
  • the lens 14 may be folded and inserted into a cartridge to be injected into the anterior chamber. After insertion of the implant 1, the flexible lens 14 may be released and recover to its initial shape.
  • the refracting lens 14 of the inventive implant has a lens shape with two surfaces, a front and a back surface 30, 32, such that the combined refractive powers of the two surfaces provides the desired degree of refraction.
  • Lenses 14 having at least one convex surface are typically employed to correct hyperopia.
  • Lenses 14 having at least one concave surface are typically employed to correct myopia.
  • Lenses 14 may have astigmatic correction on either surface.
  • the lens 14 may have a diameter between 5.0 mm and 7.0 mm, preferably at 6.0 mm.
  • the implant surfaces 30, 32 may be coated with a biocompatible polysaccharide medicament. Other compounds well known to those skilled in the art may also be used in fabricating the anterior chamber ocular implant employed in this invention.
  • the haptics 11, 11 ', 11" slope downward, preferably in a curved, parabolic, or spiral shape, suspending the lens 14 in the anterior chamber 16 of the eye 18 at a vault V between the range of 0.6 mm to 1.0 mm, preferably 0.8 mm. This configuration prevents contact of the refracting lens 14 with the natural crystalline lens 20 or iris 22, and prevents pupillary occlusion.
  • the vault V is measured in relation to a flat bottom surface 40, 40, 40" of respective contact pads, duct plate, or footplates 34, 34', 34" and the back surface 32 of the optic 14, when the implant 1 is in a resting position or implanted in the eye 18. Displacement may be either positive or negative along a sagittal direction. The change in position of the optic 14 from a resting position to a position in a posterior or anterior direction to the anatomic crystalline lens 20.
  • the haptics 11, 11 ', 11" also have a curved, parabolic, or spiral configuration in the horizontal direction.
  • the haptics 11, 11 ', 11" are designed having one or more extension pad or contact pads 34, 34', 34" that radially extend or curve at angle A from the lens 14 while maintaining uniformity in thickness in a radial direction to anchor the implant 1 in an anatomic or iridocorneal angle 31 of the eye near the scleral spur and beneath Schwalbe's line. It is foreseen that the thickness of the haptics 11, 11 ', 11" may taper towards the contact pads 34, 34', 34". The thickness of the optic lens 14 will change dependent on refractive power of lens.
  • the extension pads 34, 34', 34" create three points of contact with the iridocorneal angle 31 as will be further discussed below.
  • the haptics 11, 11 ', 11" are illustrated with a left handed orientation, but just as easily may switch to a right handed orientation (Fig. 4). Having the extension pads 34, 34', 34" radially extending in an outward direction to the iris reduces axial displacement of the implant 1 and leaves the iris free to dilate and constrict without restriction, thus avoiding the cat's eye effect.
  • the haptics 11, 11 ', 11" may be attached to the lens 14 at three points B, C, D that if linearly connected substantially create an equilateral triangle. This means that point B may be equally spaced or equal arc lengths 35, 35' from both points C and D and C is equally spaced from D.
  • the haptics 11, 11 ', 11" have a blend zone or transition 12, 12', 12" at an end of the haptics 11, 11 ', 11" that connects to the lens 14.
  • the transition 12, 12', 12" preferably has a larger width or radius than the hap tic arm 15, 15 ', 15".
  • the haptics 11, 11 ', 11" may have an inner arc length 17, 17, 17" from transition 12, 12', 12" to respective ends 26, 26', 26" that is substantially equivalent to the arc length 35, 35', 35" between contact points B, C, and D (or the arc length between transition points 12, 12', and 12").
  • the haptics arc length 17, 17', 17" may be dependent upon the iris 22 of the patient it is to be implanted in.
  • transitional portion 12, 12', 12" of the haptics 11, 1 ⁇ , 11" creates a difference in plane between the proximal and distal ends 26, 26', 26" of the haptics 11, 11 ', 11" to reduce risk of: endothelial cell 24 damage, damage to the natural crystalline lens 20 during and after surgical implantation in the anterior chamber of a phakic eye 18, glare and haloing, and ovaling of the pupil 23.
  • the contact or extension pads 34, 34', 34" are located at haptic distal ends 26, 26', 26".
  • the center 38, 38', 38" of each haptic end 26, 26', 26" runs tangential to two of the three points B, C, D.
  • An imaginary linear connection of each center 38, 38', 38" of the haptic ends 26, 26', 26” creates an equilateral triangle.
  • An imaginary circular connection of each center 38, 38', 38" of haptic ends 26, 26', 26” creates a circle. This outer circle may have a diameter of 12.0 mm, if the lens 14 diameter is 6.0 mm, i.e. about double the lens diameter.
  • the distance from the center of the lens to the haptic ends 26, 26', 26" is twice the radius of the lens.
  • the contact pads 34, 34', 34" have an outer radii 42, 42', 42" that corresponds with the contour of the anatomic angle 31.
  • the vertical and horizontal curvature of the haptics 11, 11 ', 11", as well as the positioning of the contact pads 34, 34', 34", provides both columnar and cantilever support to the implant 1, ensuring that the implant 1 will not rotate in the eye, even when external pressure is applied.
  • the refractive lens is supported by the anatomic angle 31 , it does not require sutures to anchor the lens to the eye, and therefore is easier to implant as well as extract (if needed).
  • the three-point attachment of the three contact or extension pads 34, 34', 34 minimizes contact with or adherence to the anatomic angle 31 and iris 22, and minimizes or eliminates damage to the corneal endothelium 24.
  • the haptics 11, 11 ', 11" may be made from highly flexible material, semi- flexible material, or material having varying degrees of flexibility or elasticity.
  • the haptics 11, 11 ', 11" may be made of the same material as described above for the optical portion 14 of the implant 1, or may be made of materials such as polypropylene or medical grade silicone. Depending on the composition selected, elasticity of each the haptics 11, 11 ', 11" may be varied.
  • the implant 1 may be made from a material that is invisible to someone looking at an eye 18 with an implant 1 rooted.
  • the thickness T of each haptic 11, 11 ', 11" is greater than its width or radius in order to reduce displacement of the implant 1 under diametrical compression.
  • the thickness T is between 0.1 mm and 1.0 mm, preferably around 0.6 mm.
  • FIG. 4 another embodiment of an intraocular lens implant 101 is illustrated.
  • the implant 101 and the components of the implant 101 are substantially similar to the counterparts in implant 1 , except as specifically noted and/or shown, or as would be inherent.
  • the intraocular lens implant 101 is substantially similar to the intraocular implant 1 as discussed above, with the exception that haptics 111, 111 ', 111" may have a body or frame 133.
  • the body 133 has an aperture 140 through the center defined by an inner surface 142.
  • the inner surface 142 surround a lens (not shown) and the haptics 111, 111 ', 111" are attached therein at points B', C, D' (Fig. 4) on the body 133.
  • the haptics 1 11, ⁇ ⁇ , 111" are illustrated with a right hand orientation or curvature.
  • FIG. 5 another embodiment of an intraocular lens implant 101 is illustrated.
  • the implant 201 and the components of the implant 101 are substantially similar to the counterparts in implant 1 , except as specifically noted and/or shown, or as would be inherent.
  • the intraocular lens implant 201 is substantially similar to the intraocular implant 1 as discussed above, with the exception that haptics 211, 211 ', 211", 21 ⁇ " are located 90 degrees apart and an equal or substantially equal arc length apart and there is a fourth haptic 21 ⁇ ".
  • the haptics 211, 211 ', 211", 211"' are attached at points B", C", D", E" on the lens 14.
  • the haptics 111, 111 ', 111" are illustrated with a left hand orientation or curvature.
  • the implants are constructed from a soft and flexible material, and are inserted into an eye via a 1.0 to 3.0 mm incision made in the eye via methods known in the art. Prior to the incision, the pupil is constricted to 1.0-1.5 mm via methods known in the art.
  • the implant is then folded or rolled into a configuration that can be inserted into the cartridge of an intraocular lens delivery system. After being loaded into the cartridge, the cartridge is inserted into the eye via the incision. The implant is then expelled from the cartridge and deposited into the anterior or posterior chamber of the eye, depending on whether the treated eye is phakic or aphakic.
  • the intraocular implant Upon being deposited, the intraocular implant will unfold or unroll into its original shape. The intraocular implant is then manipulated such that the lens of the intraocular implant is centered on the eye and the contact pads of the intraocular implant are positioned on the anatomic angle of the eye.
  • the intraocular implant is positioned on the eye via contact pads, there is no need to anchor the intraocular implant to the eye via sutures. Given this, the procedure can be easily reversed. Upon explantation the intraocular implant will fold on itself and have a thickness of approximately 0.2 mm, allowing the implant to be removed with ease.

Abstract

La présente invention comprend des implants intraoculaires, comprenant des lentilles intraoculaires de chambre antérieure et postérieure. Spécifiquement, l'invention concerne une lentille intraoculaire destinée à être placée dans l'angle anatomique de l'œil, l'implant comprenant une lentille réfractive ayant une surface avant et une surface arrière. De plus, l'implant comporte au moins trois projections haptiques pour le positionnement dans l'angle anatomique de l'œil, chaque projection haptique comprenant un coussinet de contact pour être en prise avec l'angle anatomique.
PCT/US2018/060095 2017-11-10 2018-11-09 Lentille intraoculaire WO2019094768A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762584184P 2017-11-10 2017-11-10
US62/584,184 2017-11-10

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WO2019094768A1 true WO2019094768A1 (fr) 2019-05-16

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10973624B1 (en) 2020-04-29 2021-04-13 Long Bridge Medical, Inc. Devices to support and position an intraocular lens within the eye and methods of use

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629460A (en) * 1984-06-25 1986-12-16 Dyer Robert L Intraocular lens
US5652014A (en) * 1991-08-16 1997-07-29 Galin; Miles A. Medicament coated refractive anterior chamber ocular implant
US20140066946A1 (en) * 2012-09-04 2014-03-06 Aaren Scientific, Inc. Preloaded Intraocular Lens (IOL) System and Method
US20160331521A1 (en) * 2015-05-11 2016-11-17 Charles DeBoer Accommodation-responsive intraocular lenses

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4629460A (en) * 1984-06-25 1986-12-16 Dyer Robert L Intraocular lens
US5652014A (en) * 1991-08-16 1997-07-29 Galin; Miles A. Medicament coated refractive anterior chamber ocular implant
US20140066946A1 (en) * 2012-09-04 2014-03-06 Aaren Scientific, Inc. Preloaded Intraocular Lens (IOL) System and Method
US20160331521A1 (en) * 2015-05-11 2016-11-17 Charles DeBoer Accommodation-responsive intraocular lenses

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10973624B1 (en) 2020-04-29 2021-04-13 Long Bridge Medical, Inc. Devices to support and position an intraocular lens within the eye and methods of use
US11759309B2 (en) 2020-04-29 2023-09-19 Long Bridge Medical, Inc. Devices to support and position an intraocular lens within the eye and methods of use

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