WO2021205144A1 - Sels d'addition d'acide organique de s-pindolol - Google Patents

Sels d'addition d'acide organique de s-pindolol Download PDF

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WO2021205144A1
WO2021205144A1 PCT/GB2021/050799 GB2021050799W WO2021205144A1 WO 2021205144 A1 WO2021205144 A1 WO 2021205144A1 GB 2021050799 W GB2021050799 W GB 2021050799W WO 2021205144 A1 WO2021205144 A1 WO 2021205144A1
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Prior art keywords
pindolol
pharmaceutically acceptable
addition salt
acid addition
pattern
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PCT/GB2021/050799
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English (en)
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Robin Chandra BHATTACHERJEE
Andrew Justin Stewart Coats
Elaine MORTEN
Ronnie Maxwell Lawrence
Jaclyn RAEBURN
Kiara Marissa LOBATO
Jonathan James LOUGHREY
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Actimed Therapeutics Ltd
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Priority to LTEPPCT/GB2021/050799T priority Critical patent/LT4132909T/lt
Priority to MX2022012492A priority patent/MX2022012492A/es
Priority to CN202180040441.2A priority patent/CN115916751A/zh
Priority to FIEP21717172.7T priority patent/FI4132909T3/fi
Priority to EP21717172.7A priority patent/EP4132909B1/fr
Priority to BR112022020198A priority patent/BR112022020198A2/pt
Priority to US17/995,621 priority patent/US20230190706A1/en
Priority to KR1020227037233A priority patent/KR20220164521A/ko
Priority to AU2021253747A priority patent/AU2021253747A1/en
Priority to DK21717172.7T priority patent/DK4132909T3/da
Priority to CA3173878A priority patent/CA3173878A1/fr
Priority to IL297045A priority patent/IL297045A/en
Priority to JP2022561648A priority patent/JP2023521985A/ja
Publication of WO2021205144A1 publication Critical patent/WO2021205144A1/fr

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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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Definitions

  • the present invention relates to a salt of S-pindolol and pharmaceutical compositions comprising the salt. Medical uses of the salt are also described. BACKGROUND OF THE INVENTION
  • S-pindolol is a b-adrenergic receptor antagonist and is also known as (-)-pindolol.
  • S-pindolol has affinity for both beta-adrenergic receptors and 5-HT 1 a receptors and is useful in treating a number of disorders.
  • WO 2008/068477 A1 describes the treatment of cachexia with S-pindolol.
  • Pindolol is authorised for the treatment of certain conditions in the form of the racemate. It has been found that S-pindolol is the more pharmacologically active enantiomer. It is a finding of the present invention that S-pindolol has characteristics which can make it difficult to formulate as an oral medicament, for instance a tablet. In particular, S-pindolol can on occasion and under certain conditions degrade and discolour during storage.
  • S-pindolol tartrate is described in Kaumann et al, British Journal of Pharmacology 1986 89 (1) 207-218.
  • S-pindolol hydrochloride is described in Japanese patent application JPH01287064 (A).
  • the racemic benzoate salt of pindolol is described in Pietilainen et al, Drug Development and Industrial Pharmacy, 22(11 ), 1063-1073 (1996).
  • salts of S-pindolol formed with organic mono- and di- carboxylic acids having a pK a of at least 2.5 are well suited to pharmaceutical formulation.
  • these salts have been found to be stable, crystalline and to have increased melting points compared to S-pindolol free base.
  • Several of the S- pindolol salts also have a pure white colour which is desirable for clinical use of the solid form.
  • the invention provides a pharmaceutically acceptable acid addition salt of: (i) S- pindolol; and (ii) an organic acid, wherein the organic acid has: a pK ai of greater than or equal to 2.5; and a chemical formula of Cxhly(C02pl)z, where x is from 1 to 10, y is from 2 to 20 and z is 1 or 2.
  • the invention also provides a composition comprising at least 60 wt% of the pharmaceutically acceptable acid addition salt.
  • composition comprising (i) the pharmaceutically acceptable acid addition salt and (ii) a pharmaceutically acceptable excipient, carrier or diluent.
  • the pharmaceutically acceptable acid addition salt for use in the treatment of the human or animal body is also provided by the invention.
  • Figure 1 shows the XRPD 2Q diffractogram of S-pindolol free base Pattern 1.
  • Figure 2 shows the XRPD 2Q diffractograms of the solids obtained from treatment of S-pindolol with fumaric acid.
  • Figure 3 shows the TG/DSC thermogram of S-pindolol hemi-fumarate Pattern 1 .
  • Figure 4 shows the TG/DSC thermogram of S-pindolol hemi-fumarate Pattern 2.
  • Figure 5 shows the TG/DSC thermogram of S-pindolol hemi-fumarate Pattern 3.
  • Figure 6 shows the XRPD 2Q Diffractogram of S-pindolol benzoate Pattern 1.
  • Figure 7 shows the FT-IR spectrum of S-pindolol benzoate Pattern 1 .
  • Figure 8 shows the TG/DSC thermogram of S-pindolol benzoate Pattern 1.
  • Figure 9 shows the DSC thermogram of S-pindolol benzoate Pattern 1 (first heating cycle).
  • Figure 10 shows the DSC thermogram of S-pindolol benzoate Pattern 1 (second heating cycle).
  • Figure 11 shows the XRPD 2Q diffractogram of S-pindolol benzoate Pattern 2.
  • Figure 12 shows the FT-IR Spectrum of S-pindolol benzoate Pattern 2.
  • Figure 13 shows the TG/DSC thermogram of S-pindolol benzoate Pattern 2.
  • Figure 14 shows the DSC thermogram of S-pindolol benzoate Pattern 2 (first heating cycle).
  • Figure 15 shows the DSC thermogram of S-pindolol benzoate Pattern 2 (second heating cycle).
  • Figure 16 shows the XRPD 2Q diffractogram of S-pindolol succinate Pattern 1 .
  • Figure 17 shows the FT-IR Spectrum of S-pindolol succinate Pattern 1 .
  • Figure 18 shows the TG/DSC thermogram of S-pindolol succinate Pattern 1 .
  • Figure 19 shows the DSC thermogram of S-pindolol succinate Pattern 1 (first heating cycle).
  • Figure 20 shows the DSC thermogram of S-pindolol succinate Pattern 1 (second heating cycle).
  • Figure 21 shows the XRPD diffractogram of S-pindolol benzoate Pattern 2 obtained from methlylethyl ketone.
  • Figure 22 shows the XRPD diffractograms of samples of S-pindolol benzoate obtained from the competitive slurry experiments.
  • the organic acid has a pK ai of greater than or equal to 2.5.
  • the organic acid is a relatively weak acid.
  • the organic acid preferably has a pKai of from 3.0 to 5.0.
  • the pKai of the organic acid may be from 4.0 to 4.5.
  • pKai is the acid dissociation constant of the first proton to dissociate from the acid.
  • pKai corresponds simply to the acid dissociation constant pK a .
  • the pKai values are as measured at 25 °C.
  • pKa and pKai values for organic acids are readily available to the skilled person.
  • the organic acid has the chemical formula of CxH y (C02H) z , where x is from 1 to 10, y is from 2 to 20 and z is 1 or 2.
  • the organic acid comprises a hydrocarbyl moiety (CxH y , consisting of hydrogen and carbon) and one or two carboxylic acid groups (CO2H).
  • x is from 2 to 7 and H is from 2 to 6.
  • the CxH y group may be an arenyl group, an alkyl group or an alkenyl group.
  • the CxH y group may be a divalent C2-7 alkyl group, a divalent C2-7 alkenyl group or a divalent phenyl group optionally substituted with one or two methyl groups.
  • the organic acid may, for instance, be benzoic acid, succinic acid, fumaric acid, malonic acid, acetic acid, propionic acid, glutaric acid, adipic acid, phenylacetic acid, toluic acid (including 0-, m- and p-toluic acid) and naphthoic acid (including 1 - and 2- naphthoic acid).
  • the pKai of these acids are shown in the table below. Where the acid is a monocarboxylic acid, the stated pKai is the pKa for that acid.
  • the organic acid is benzoic acid or succinic acid.
  • the organic acid is benzoic acid.
  • the pharmaceutically acceptable acid addition salt is a salt of S-pindolol and therefore comprises a cation formed from S-pindolol.
  • the cation formed from S- pindolol typically has the following structure:
  • the enantiomeric excess of the S-enantiomer of the cation of pindolol in the pharmaceutically acceptable salt is typically at least 80 %. Thus, of the cations in the salt, at least 90 mol% are typically in the S-configuration. The enantiomeric excess is typically at least 95 %.
  • the cation of S-pindolol in the pharmaceutically acceptable acid addition salt is typically substantially in S-configuration and therefore may have an enantiomeric excess of at least 99 %. Enantiomeric excess may be measured by any standard technique, for instance by measuring optical rotation or using chiral high performance liquid chromatography (HPLC).
  • the pharmaceutically acceptable acid addition salt typically does not therefore comprise greater than 10 mol% of the R-enantiomer of pindolol or a salt comprising a cation which is a protonated R-pindolol molecule.
  • the pharmaceutically acceptable acid addition salt is typically substantially free of the R- enantiomer of pindolol or a salt comprising a cation which is a protonated R-pindolol molecule.
  • the pharmaceutically acceptable acid addition salt is typically crystalline.
  • the salt accordingly may have a three dimensional crystal structure comprising repeating unit cells.
  • the pharmaceutically acceptable acid addition salt may be in a solid form, for instance a solid form comprising crystals or crystallites of the pharmaceutically acceptable acid addition salt.
  • the pharmaceutically acceptable acid salt may be in the form of a solvate.
  • a solvate of a salt is a solid form of the salt which comprises molecules of a solvent.
  • the salt may be a hydrate.
  • the salt is not a solvate.
  • the pharmaceutically acceptable acid addition salt may be anhydrous.
  • the pharmaceutically acceptable acid addition salt typically has a melting point which is greater than the melting point of S-pindolol free base.
  • the salt may have a melting point of greater than or equal to 100 °C, for instance from 110 °C to 170 °C.
  • the salt has a melting point of 130 °C to 160 °C.
  • the melting point may, for instance, be as determined used differential scanning calorimetry (DSC).
  • the pharmaceutically acceptable acid addition salts may be formed by any suitable method.
  • S-pindolol free base is treated with the organic acid in a solvent.
  • the solvent may be water, an alcohol (for instance ethanol or 2-propanol), an ester (for instance ethyl acetate), a ketone (for instance acetone) or an ether (for instance tetrahydrofuran (THF) or ethyl ether).
  • the pharmaceutically acceptable acid addition salt produced may be dissolved in the solvent or may precipitate out of solution.
  • the pharmaceutically acceptable acid addition salt may be isolated by a suitable method, for instance by filtration or by solvent evaporation.
  • the pharmaceutically acceptable acid addition salt may be S-pindolol benzoate.
  • the salt may accordingly comprise the cation derived from S-pindolol and a benzoate anion.
  • the stoichiometry of the cation and anion is typically about 1 :1 , for instance from 0.9:1.0 to 1.1 :1.0 (i.e. for each mole of the anion, there may be from 0.9 to 1.1 moles of the cation).
  • the S-pindolol benzoate is S-pindolol monobenzoate.
  • the salt may be of formula [Ci4H2iN202] + [C6H6C00] .
  • the pharmaceutically acceptable acid addition salt is typically crystalline.
  • the S-pindolol benzoate may be in the form of the crystalline polymorph of S- pindolol benzoate designated as Pattern 1 .
  • Pattern 1 of S-pindolol benzoate typically has an x-ray powder diffraction (XRPD) pattern comprising peaks at 8.1 °, 11.4° and 17.0° ⁇ 0.2° 2Q.
  • XRPD x-ray powder diffraction
  • the XRPD pattern of S-pindolol benzoate Pattern 1 typically further comprises peaks at 5.7°, 12.5° and 18.4° ⁇ 0.2° 2Q.
  • the XRPD pattern of S-pindolol benzoate Pattern 1 may comprise five or more peaks selected from 5.7°, 8.1°, 11.4°, 12.5°, 12.8°, 15.4°, 16.2°, 17.0°, 18.4°, 20.2°, 23.0°, 23.8°, 24.0° and 25.1 ° ⁇ 0.2° 2Q.
  • the XRPD pattern may comprise all of these peaks.
  • the XRPD pattern of S-pindolol benzoate Pattern 1 may comprise the following peaks.
  • the XRPD pattern of S-pindolol benzoate Pattern 1 may be substantially as shown in figure 6.
  • the infrared spectrum of S-pindolol benzoate Pattern 1 typically comprises one or more peaks in the following ranges: 1638-1648 cm 1 , 2964-2974 cm -1 , 3022-3032 cm 1 and 3250-3260 cm 1 .
  • the infrared spectrum may comprise peaks at about 1643 cm -1 , 2969 cnr 1 , 3027 cnr 1 and 3255 cm -1 .
  • the melting point of S-pindolol benzoate Pattern 1 is typically in the range of 130 to 140°C, for instance about 135 °C.
  • S-pindolol benzoate Pattern 1 may be produced by a process comprising recrystallizing S-pindolol benzoate from a solvent which is 1 -butanol, 1 -propanol, 1 ,2-dichloroethane, 1 ,4-dioxane, 2-methyl THF, 2-methyl-1 -propanol, 2-propanol, acetone, acetonitrile, ethyl acetate, isopropyl acetate, methanol, methylisobutyl ketone and 2-ethoxyethanol.
  • a solvent which is 1 -butanol, 1 -propanol, 1 ,2-dichloroethane, 1 ,4-dioxane, 2-methyl THF, 2-methyl-1 -propanol, 2-propanol, acetone, acetonitrile, ethyl acetate, isopropyl acetate, methanol
  • S-pindolol benzoate may be in the form of the crystalline polymorph of S- pindolol benzoate designated as Pattern 2.
  • S-pindolol benzoate Pattern 2 typically has an x-ray powder diffraction (XRPD) pattern comprising a peak at 9.2° ⁇ 0.2° 2Q.
  • S-pindolol benzoate Pattern 2 typically has an x-ray powder diffraction (XRPD) pattern comprising peaks at 16.9°, 18.9° and 20.1° ⁇ 0.2° 2Q.
  • the XRPD pattern of S-pindolol benzoate Pattern 2 typically further comprises peaks at 9.2°, 13.9° and 20.7° ⁇ 0.2° 2Q.
  • the XRPD pattern of S-pindolol benzoate Pattern 2 may comprise five or more peaks at selected from 8.3°, 9.2°, 12.4°, 13.0°, 13.9°, 16.9°, 18.5°, 18.9°, 19.1°,
  • the XRPD pattern may comprise all of these peaks.
  • the XRPD pattern of S-pindolol benzoate Pattern 2 may comprise the following peaks.
  • the XRPD pattern of S-pindolol benzoate Pattern 2 may be substantially as shown in figure 11 or figure 21 .
  • the infrared spectrum of S-pindolol benzoate Pattern 2 typically comprises one or more peaks in the following ranges: 1630-1640 cm -1 , 2924-2934 cm -1 , 3093-3103 cm -1 and 3214-3224 cm 1 .
  • the infrared spectrum may comprise peaks at about 1635 cm 1 , 2929 cm 1 , 3098 cm 1 and 3219 cm 1 .
  • the melting point of S-pindolol benzoate Pattern 2 is typically in the range of 153 to 163°C, for instance about 158 °C.
  • S-pindolol benzoate Pattern 2 may be produced by a process comprising recrystallizing S-pindolol benzoate from a solvent which is ethanol, methanol:water (for instance 95:5 % v/v), methylethyl ketone, tetrahydrofuran and water.
  • S-pindolol benzoate Pattern 2 may be obtained by recrystallizing S-pindolol benzoate from methylethyl ketone.
  • S-pindolol benzoate Pattern 2 has been found to be the thermodynamically stable form of S-pindolol benzoate.
  • the S-pindolol benzoate is accordingly preferably in the form of S-pindolol benzoate Pattern 2.
  • the pharmaceutically acceptable acid addition salt may be S-pindolol succinate.
  • the salt may accordingly comprise the cation derived from S-pindolol and a succinate anion.
  • the stoichiometry of the cation and anion is typically about 1 :1 or about 2:1 , for instance from 0.9:1 .0 to 11 :1.0 or from 1 .9:1.0 to 2.1 :10.
  • the S- pindolol succinate may accordingly be S-pindolol hemisuccinate or S-pindolol monosuccinate.
  • the S-pindolol succinate is S-pindolol monosuccinate.
  • the salt may be of formula [Ci4H2iN202] + [H00C(C2H4)C00] or ([C14H2I N202] + )2[00C(C2H4)C00] 2 -.
  • the S-pindolol succinate may be in the form of the crystalline polymorph of S- pindolol succinate designated as Pattern 1.
  • S-pindolol succinate Pattern 1 typically has an x-ray powder diffraction (XRPD) pattern comprising peaks at 13.3°, 16.7° and 19.5° ⁇ 0.2° 2Q.
  • the XRPD pattern of S-pindolol succinate Pattern 1 typically further comprises peaks at 8.3°, 12.2° and 12.8° ⁇ 0.2° 2Q.
  • the error margin in the peak locations may be t 0.1° 2Q.
  • the XRPD pattern of S-pindolol succinate Pattern 1 may comprise five or more peaks at selected from 8.3°, 12.2°, 12.8°, 13.3°, 16.7°, 16.9°, 19.5°, 21.5°, 22.0°, 22.7°, 24.1°, 24.3°, 25.0° ⁇ 0.2° 2Q.
  • the XRPD pattern of S-pindolol succinate Pattern 1 may comprise the following peaks.
  • the XRPD pattern of S-pindolol succinate Pattern 1 may be substantially as shown in figure 16.
  • the infrared spectrum of S-pindolol succinate Pattern 1 typically comprises one or more peaks in the following ranges: 1685-1695 cm 1 , 2965-2975 cm -1 , 3148-3158 cm -1 and 3384-3394 cm -1 .
  • the infrared spectrum may comprise peaks at about 1690 cm 1 , 2970 cm 1 , 3153 cm 1 and 3389 cm 1 .
  • the melting point of S-pindolol succinate Pattern 1 is typically in the range of 110 to 120°C, for instance about 115 °C.
  • S-pindolol succinate Pattern 1 may be produced by a process comprising: (i) providing S-pindolol free base and succinic acid; (ii) adding THF to the S-pindolol free base and succinic acid to produce a mixture; (iii) cycling the temperature of the mixture from a lower of 15 °C to 30 °C to a higher temperature of 35 °C to 50 °C and back again over cycles lasting from 3 to 5 hours for a total time of from 60 to 120 hours; (iv) filtering the salt produced; and (v) drying the salt at a temperature of from 35 °C to 50 °C for from 18 to 48 hours.
  • the pharmaceutically acceptable acid addition salt typically has a purity of greater than or equal to about 90%, greater than or equal to about 95% or greater than or equal to about 97%.
  • the percentage purity may be calculated as area % based on HPLC separation.
  • the composition of the invention comprises at least 60 wt% of the pharmaceutically acceptable acid addition salt.
  • the composition may comprise at least 80 wt% or at least 95 wt% of the pharmaceutically acceptable acid addition salt relative to the total weight of the composition.
  • the composition may consist essentially of the pharmaceutically acceptable acid addition salt.
  • the composition may consist of the pharmaceutically acceptable acid addition salt.
  • the composition accordingly typically comprises no more than 30 wt% of R-pindolol or a salt thereof relative to the total weight of the composition.
  • the composition may comprise no more than 10 wt%, or no more than 1 wt%, of R- pindolol or a salt thereof relative to the total weight of the composition.
  • the pharmaceutical composition of the invention comprises (i) the pharmaceutically acceptable acid addition salt and (ii) a pharmaceutically acceptable excipient, carrier or diluent.
  • the pharmaceutical composition may, for instance, be: a tablet, capsule, powder, solution or suspension for oral administration; a solution or suspension for injection; or a solution, suspension or powder for inhalation.
  • the pharmaceutical composition is typically a tablet.
  • the diluent may be any pharmaceutically acceptable diluent.
  • the diluent is typically suitable for parenteral administration or for oral administration.
  • suitable liquid diluents include water, ethanol and glycerol.
  • the diluent may alternatively be selected from solid diluents such as lactose, dextrose, saccharose, cellulose, corn starch and potato starch.
  • the diluent may contain buffer components to control the pH.
  • the buffers may be derived from phosphate, citrate or acetate.
  • the diluent may also contain sodium chloride.
  • the pharmaceutical composition may comprise an excipient selected from: lubricants, e.g. silica, talc, stearic acid, magnesium or calcium stearate, and/or polyethylene glycols; binding agents, e.g. starches, arabic gums, gelatin, methylcellulose, carboxymethylcellulose or polyvinyl pyrrolidone; disaggregating agents, e.g. starch, alginic acid, alginates or sodium starch glycolate; effervescing mixtures; dyestuffs; sweeteners; wetting agents, such as lecithin, polysorbates, laurylsulphates; and, in general, non-toxic and pharmacologically inactive substances used in pharmaceutical formulations.
  • lubricants e.g. silica, talc, stearic acid, magnesium or calcium stearate, and/or polyethylene glycols
  • binding agents e.g. starches, arabic gums, gelatin, methylcellulose, carboxymethylcellulose
  • Such pharmaceutical preparations may be manufactured in known manner, for example, by means of mixing, granulating, tableting, sugar coating, or film coating processes.
  • the pharmaceutical composition may for instance be a tablet comprising one or more excipients selected from magnesium stearate, colloidal silica, microcrystalline cellulose, strearyl fumarate and starch.
  • compositions which are liquid dispersions for oral administration may be syrups, emulsions and suspensions.
  • the syrups may contain as carriers, for example, saccharose, glycerine, mannitol or sorbitol.
  • compositions which are suspensions or emulsions may contain as carrier, for example a natural gum, agar, sodium alginate, pectin, methylcellulose, carboxymethylcellulose, or polyvinyl alcohol.
  • the suspension or solutions for intramuscular injections may contain, together with the pharmaceutically acceptable acid addition sat, a pharmaceutically acceptable carrier, e.g. sterile water, olive oil, ethyl oleate, glycols, e.g. propylene glycol, and if desired, a suitable amount of lidocaine hydrochloride.
  • Solutions for injection or infusion, or for inhalation may contain as carrier, for example, sterile water or they may be in the form of sterile, aqueous, isotonic saline solutions.
  • the pharmaceutical composition may comprise the pharmaceutically acceptable acid addition salt in an amount equivalent to from 0.1 to 1000 mg of S-pindolol free base.
  • the pharmaceutical composition may comprise the pharmaceutically acceptable acid addition salt in an amount equivalent to from 80 to 160 mg or from 2.5 to 50 mg of S-pindolol free base.
  • the pharmaceutical composition may comprise the salt in an amount equivalent to from 2.5 to 15 mg of S-pindolol free base.
  • 3.7 mg of S-pindolol benzoate (molecular weight 370.4 gmol -1 ) is equivalent to 2.5 mg S-pindolol free base (molecular weight 248.3 gmol 1 ).
  • the pharmaceutical composition is typically substantially free of R-pindolol or a salt thereof.
  • the pharmaceutical composition may comprise less than 1.0 wt%, or less than 0.5 wt%, of R-pindolol or a salt thereof. Medical uses
  • the pharmaceutically acceptable acid addition salt is useful in the treatment or prevention of a disease or condition selected from cachexia, sarcopenia, a neuromuscular disorder, muscle weakness, hypertension, heart failure, atrial fibrillation, heart attack, angina pectoris, glaucoma and anxiety.
  • a disease or condition selected from cachexia, sarcopenia, a neuromuscular disorder, muscle weakness, hypertension, heart failure, atrial fibrillation, heart attack, angina pectoris, glaucoma and anxiety.
  • a disease or condition selected from cachexia and muscle weakness.
  • the cachexia may be caused by an underlying condition.
  • the cachexia may be caused by cancer, heart failure, chronic obstructive pulmonary diseases (COPD), liver failure, kidney failure, stroke, rheumatoid arthritis, severe burn injury or HIV/ AIDS.
  • COPD chronic obstructive pulmonary diseases
  • the muscle weakness may be caused by an underlying condition.
  • the muscle weakness may be caused by trauma, musculoskeletal injury, surgery or immobilization.
  • the muscle weakness may be intensive care unit acquired weakness (ICUAW).
  • the neuromuscular disorder may for instance be amyotrophic lateral sclerosis.
  • the invention also provides a method of treating or preventing a disease or condition selected from cachexia, sarcopenia, a neuromuscular disorder, muscle weakness, hypertension, heart failure, atrial fibrillation, heart attack, angina pectoris, glaucoma and anxiety in an individual, the method comprising administering a therapeutically effective amount of the pharmaceutically acceptable acid addition salt to the individual.
  • a disease or condition selected from cachexia, sarcopenia, a neuromuscular disorder, muscle weakness, hypertension, heart failure, atrial fibrillation, heart attack, angina pectoris, glaucoma and anxiety
  • the pharmaceutically acceptable acid addition salt is typically administered orally or parenterally.
  • An effective amount of the pharmaceutically acceptable acid addition salt is typically an amount equivalent to from 0.1 to 1000 mg of S-pindolol free base for a single dose.
  • a single dose of the pharmaceutically acceptable acid addition salt may be a dose equivalent to from 2.5 to 50 mg or from 80 to 160 mg of S- pindolol free base.
  • a single dose may be an amount of the salt equivalent to from 2.5 to 15 mg of S-pindolol free base.
  • the dose may be administered once, twice or three times a day.
  • Infrared spectroscopy was carried out on a Bruker ALPHA P spectrometer. Sufficient material was placed onto the centre of the plate of the spectrometer and the spectra were obtained using the following parameters:
  • NMR experiments were performed on a Bruker AVI I IHD spectrometer equipped with a DCH cryoprobe operating at 500.12 MHz for protons. Experiments were performed in deuterated DMSO or methanol and each sample was prepared to ca. 10 mM concentration.
  • TG/DSC analysis found no mass losses by TG until degradation from ca. 200 °C. This indicated that the material was anhydrous and non-solvated.
  • An endothermic event was observed in the DSC with an onset of 82 °C and peak of 84 °C which was attributed to a solid-solid transition.
  • a larger endothermic event was observed with an onset of 93 °C and peak of 95 °C due to melting.
  • the counterions used were those derived from the following acids: hydrochloric acid (pKai of -6), sulfuric acid (pKai of -3), p-toluenesulfonic acid.hteO (pKai of -1.34), methanesulfonic acid (pKai of -1.2), maleic acid (pKai of 1.92), phosphoric acid (pKai of 1.96), L-tartaric acid (pKai of 3.02), fumaric acid (pKai of 3.03), citric acid (pKai of 3.13), S-(+)-mandelic acid (pKai of 3.37), benzoic acid (pKai of 4.19) and succinic acid (pKai of 4.21).
  • hydrochloric acid pKai of -6
  • sulfuric acid pKai of -3
  • p-toluenesulfonic acid.hteO pKai of -1.3
  • the solvents used were water, ethanol, 2-propanol, ethyl acetate, acetone and tetrahydrofuran (THF).
  • the samples were temperature cycled between ambient temperature and 40 °C in 4 hour cycles for 72 hours. Any solids formed were isolated via centrifugation before being analysed by XRPD. A number of the solids obtained after initial temperature cycling were found to be coloured. In particular, the products formed using sulfuric acid, p-toluenesulfonic acid, methanesulfonic acid, maleic acid, phosphoric acid, L-tartaric acid, fumaric acid and citric acid were coloured when certain solvents were used. 0.5 mL of anti-solvent was then added to vials that contained insufficient solids for
  • the XRPD of the product formed using hydrochloric acid was found to correspond to that of S-pindolol free base.
  • Gums were formed from most solvents when S-pindolol was treated with tartaric acid.
  • a solid product was formed when ethyl acetate was used as the solvent.
  • the solid product from ethyl acetate and tartaric acid was found to be S-pindolol free base. It was not therefore possible to produce a crystalline salt of S-pindolol with tartaric acid.
  • the salts formed with fumaric acid, benzoic acid and succinic acid were found to be crystalline, with XRPD patterns different from that of S-pindolol free base.
  • the fumaric acid salts were coloured when formed from water, ethanol, 2-propanol and acetone, and white when formed from ethyl acetate and THF.
  • the succinic acid salts were coloured when formed from water, and were otherwise white.
  • the benzoic acid salts were white when formed from any solvent.
  • the primary salt screen therefore found that crystalline solid salt forms could be formed from fumaric acid, benzoic acid and succinic acid. Salts formed with these three acids were characterised further.
  • Pattern 1 and 2 are similar, although peaks below 10° 2Q were not present in Pattern 1. Therefore, Pattern 2 may be a mixture containing Pattern 1 .
  • Patterns 1 , 2 and 3 were characterised as follows. Hemi-fumarate Pattern 1
  • Samples of S-pindolol hemi-fumarate Pattern 2 was stored at 60°C (sealed vial) or 40°C/75% RH (open vial) for 7 days.
  • the sample stored at 60°C converted to Pattern 1.
  • the sample stored at 40°C/75% RH converted to a different form, Pattern 4.
  • the scintillation vial was capped and sealed with parafilm and then temperature cycled between ambient temperature and 40°C over 4-hour cycles for ca. 72 hours.
  • the benzoate salt was characterised by XRPD, 1 H NMR, TG/DSC, DSC, and FT-IR.
  • S-pindolol benzoate Pattern 1 The 2Q values and peak intensities for S-pindolol benzoate Pattern 1 are shown in Table 2 below.
  • Flack -0.03(4)
  • a 1 : 1 ratio of benzoic acid and S-pindolol was observed and a broad water peak was present, indicating salt formation was successful.
  • the presence of 0.69 wt. % (0.03 eq.) of ethyl acetate was observed.
  • TG and DSC scans of S-pindolol benzoate Pattern 1 are shown in figures 8 to 10.
  • TG/DSC analysis found a 40 % mass loss by TG between 150 °C and 250 °C followed by degradation. This weight loss was likely due to degradation but also equates to 2 eq. of benzoic acid. An endothermic event was observed in the DSC with an onset of 130 °C and peak of 135 °C.
  • DSC analysis found a sharp endothermic event with an onset at 130 °C and peak at 135 °C. This corresponds to the melt and matches the TG/DSC data. No events were observed in the cooling cycle. A glass transition with a midpoint at 44 °C and an endothermic event with an onset at 133 °C and peak at 136 °C were observed in the second heating cycle.
  • the sample was temperature cycled between ambient and 40 °C over 4-hour cycles for ca. 24 hours.
  • the material was filtered on a BCichner funnel and left to dry on the filter paper for ca. 5 minutes. The material was then returned to the sample vial and dried under vacuum at 40 °C for ca. 6 hours.
  • the benzoate salt was characterised by XRPD, 1 H NMR, TG/DSC, DSC, and FT-IR. S-pindolol benzoate Pattern 2 characterisation
  • S-pindolol benzoate Pattern 2 The 2Q values and peak intensities for S-pindolol benzoate Pattern 2 are shown in Table 3 below.
  • TG and DSC scans of S-pindolol benzoate Pattern 2 are shown in figures 13 to 15.
  • TG/DSC analysis found a 42.8 wt. % mass loss in the TG trace. This was likely due to decomposition.
  • a sharp endothermic event was observed in the DSC trace associated with melting with an onset at 156 °C and peak at 158 °C.
  • the succinate salt was characterised by XRPD, 1 H NMR, TG/DSC, DSC, and FT-IR.
  • S-pindolol succinate Pattern 1 The 2Q values and peak intensities for S-pindolol succinate Pattern 1 are shown in Table 4 below.
  • 1 H NMR found a 1 : 1 ratio of ACM-001 to succinic acid and 0.04 equiv. of THF.
  • TG and DSC scans of S-pindolol succinate Pattern 1 are shown in figures 18 to 20.
  • TG/DSC analysis found a 12 % mass loss by TG between 160 °C and 250 °C followed by degradation. This weight loss could be due to degradation but also corresponds to 0.42 eq. succinic acid.
  • An endothermic event was observed in the DSC with an onset of 111 °C and peak of 115 °C.
  • DSC analysis found a sharp endothermic event with an onset at 110 °C and peak at 114 °C. This corresponds to the melt and matches the TG/DSC data. No events were observed in the cooling cycle. A glass transition was observed with a midpoint at 39 °C in the second heating cycle.
  • the stability of S-pindolol succinate Pattern 1 was assessed.
  • the succinate Pattern 1 salt retained its form after storage for 7 days at 60 °C and 40 °C/75 % RH. No colour changes were observed, purity was maintained and there was no change in the solid form of succinate Pattern 1 after storage at four weeks under all conditions.
  • the succinate salt was also analysed by DVS. During DVS analysis, succinate Pattern 1 was retained with mass uptake of 0.70 wt% (0.14 eq.) water at 90 % RH.
  • S-pindolol free base was found to be crystalline with an unclear morphology.
  • the thermal properties found were: degradation after 200 °C; a solid-solid transition at 83 °C; and a melt at 93 °C.
  • the free base was slightly hygroscopic with an uptake of 0.05 eq. water up to 90 % RH.
  • a salt screen was carried out successfully on S-pindolol. With many counterions, only amorphous products or gums were identified. Crystalline salt forms were identified using fumaric acid, benzoic acid and succinic acid.
  • the hemi-fumarate salts were found to interconvert between different polymorphic forms during stability testing and were deemed less desirable salt forms.
  • the fumaric salt products also tended to be coloured.
  • S-pindolol benzoate Pattern 1 was found to be a crystalline white solid with a higher melting point than the free base (with an onset at 130 °C, while decomposition started around 150 °C).
  • S-pindolol benzoate Pattern 2 was found to be a crystalline white solid with a higher melting point than the free base (with a melting point onset at 156 °C associated with concurrent decomposition).
  • S-pindolol succinate Pattern 1 was found to be a crystalline off-white solid with a higher melting point than the free base (with an onset at 111 °C, while decomposition started around 160 °C).
  • the chemical and physical properties of S-pindolol benzoate and S-pindolol succinate are highly advantageous and make them well suited to development for pharmaceutical uses.
  • the pure white colour, better morphology, higher melting point, lower hygroscopicity, and stability determined for S-pindolol benzoate means that this salt is particularly preferred.
  • Pattern 2 was obtained from solvents such as methylethyl ketone, ethanol, THF and water.
  • the XRPD pattern of Pattern 2 obtained from methylethyl ketone is shown in figure 21.
  • Pattern 2 S-pindolol benzoate Pattern 1.
  • Pattern 2 a different pattern, Pattern 2 was recovered from ethanol, methanol/water mixtures, methylethyl ketone, THF and water. Mixtures of Patterns 1 and 2 were observed from anisole, butyl acetate and toluene.
  • benzoate Pattern 2 was obtained from all polymorph screen experiments that yielded crystalline material and appeared to be the thermodynamic form based on competitive slurry experiments and higher melt onset compared to Pattern 1.
  • S-pindolol benzoate Pattern 2 was found to be a crystalline white solid with birefringent crystals ca. 10 pm in size with an unclear morphology. Pattern 2 was an anhydrous mono-benzoate salt. The thermal properties of S-pindolol benzoate Pattern 2 improved upon Pattern 1 , which supported the theory of Pattern 2 being the thermodynamic form. A higher melting point was obtained with an onset at 156 °C compared to 130 °C for Pattern 1. Decomposition of Pattern 2 occurred at the same temperature as the melt onset. Additionally, a glass transition was observed in the second heating cycle with a midpoint at 27 °C.
  • S-pindolol benzoate Pattern 2 was non-hygroscopic with an uptake of 0.045 wt. % (0.01 eq.) water at 90 %RH.
  • HPLC analysis found the material to be of 99.9 % purity by relative area and an 99.4 % ee by chiral HPLC.
  • Pattern 2 found that Pattern 2 retained its XRPD pattern and high chemical purity (above 99.8 % by relative area) at all stability conditions. Pattern 2 retained its white colour for 7 days at all stability conditions and for 14 days at 60 °C and elevated humidity.
  • S-pindolol benzoate Pattern 2 showed fairly high solubility (with free base concentrations of 23.5 mg/mL, 17.6 mg/mL, 9.9 mg/mL, and 10.3 mg/mL) observed in pH 1.2, 4.5, 6.8 buffers and unbuffered water, respectively.
  • S-pindolol benzoate Pattern 2 improved upon the solubility in unbuffered water of the free base which was 1.8 mg/mL
  • the chemical and physical properties of S-pindolol benzoate Patterns 1 and 2 make them both developable salt forms. However, S-pindolol benzoate Pattern 2 was the preferred salt form due to it being the thermodynamic form.

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Abstract

L'invention concerne un sel d'addition d'acide pharmaceutiquement acceptable de : (I) S-pindolol ; et (ii) un acide organique, l'acide organique ayant : un pKa1 supérieur ou égal à 2,5 ; et une formule chimique de CxHy(CO2H)z, x étant de 1 à 10, y étant de 2 à 20 et z étant 1 ou 2. Le sel d'addition d'acide pharmaceutiquement acceptable est utile dans le traitement d'états tels que la cachexie, la sarcopénie, un trouble neuromusculaire et une faiblesse musculaire.
PCT/GB2021/050799 2020-04-07 2021-03-31 Sels d'addition d'acide organique de s-pindolol WO2021205144A1 (fr)

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LTEPPCT/GB2021/050799T LT4132909T (lt) 2020-04-07 2021-03-31 S-pindololio organinės rūgšties prisijungimo druska
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CN202180040441.2A CN115916751A (zh) 2020-04-07 2021-03-31 S-吲哚洛尔的有机酸加成盐
FIEP21717172.7T FI4132909T3 (fi) 2020-04-07 2021-03-31 S-pindololin orgaanisia happolisäyssuoloja
EP21717172.7A EP4132909B1 (fr) 2020-04-07 2021-03-31 Sels d'addition d'acide organique de s-pindolol
BR112022020198A BR112022020198A2 (pt) 2020-04-07 2021-03-31 Sal de adição de ácido farmaceuticamente aceitável, composição, composição farmacêutica e método de tratamento ou prevenção de uma doença ou condição
US17/995,621 US20230190706A1 (en) 2020-04-07 2021-03-31 Organic acid addition salts of s-pindolol
KR1020227037233A KR20220164521A (ko) 2020-04-07 2021-03-31 S-핀돌롤의 유기산 부가염
AU2021253747A AU2021253747A1 (en) 2020-04-07 2021-03-31 Organic acid addition salts of S-pindolol
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IL297045A IL297045A (en) 2020-04-07 2021-03-31 salts of s-pindolol
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WO2023062351A1 (fr) * 2021-10-12 2023-04-20 Actimed Therapeutics Ltd Formulation orale

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WO2023062351A1 (fr) * 2021-10-12 2023-04-20 Actimed Therapeutics Ltd Formulation orale

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