WO2021187729A1 - 혈압측정 시스템 및 이를 이용한 혈압 측정 방법 - Google Patents

혈압측정 시스템 및 이를 이용한 혈압 측정 방법 Download PDF

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Publication number
WO2021187729A1
WO2021187729A1 PCT/KR2020/019031 KR2020019031W WO2021187729A1 WO 2021187729 A1 WO2021187729 A1 WO 2021187729A1 KR 2020019031 W KR2020019031 W KR 2020019031W WO 2021187729 A1 WO2021187729 A1 WO 2021187729A1
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Prior art keywords
blood pressure
pressure
sensor
arterial wave
wave
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PCT/KR2020/019031
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English (en)
French (fr)
Korean (ko)
Inventor
이동화
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Charmcare Co Ltd
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Charmcare Co Ltd
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Priority to US17/912,859 priority Critical patent/US20230181049A1/en
Priority to JP2022556661A priority patent/JP2023518092A/ja
Priority to CN202080098799.6A priority patent/CN115334960A/zh
Publication of WO2021187729A1 publication Critical patent/WO2021187729A1/ko
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A61B5/02116—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics of pulse wave amplitude
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/02108—Measuring pressure in heart or blood vessels from analysis of pulse wave characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/024—Measuring pulse rate or heart rate
    • A61B5/02416—Measuring pulse rate or heart rate using photoplethysmograph signals, e.g. generated by infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/053—Measuring electrical impedance or conductance of a portion of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0247—Pressure sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14552—Details of sensors specially adapted therefor

Definitions

  • the present invention relates to a blood pressure monitor and a blood pressure measuring method, and more particularly, to a blood pressure measuring system capable of quickly calculating a blood pressure value by detecting an arterial wave for a short time, and a blood pressure measuring method using the same.
  • blood pressure is a measure of the pressure that blood exerts on the walls of blood vessels, and the heart repeats contraction and relaxation about 60 to 80 times per minute.
  • the pressure exerted on the blood vessels when the heart contracts and pushes blood is called 'systolic pressure' and is called 'systolic blood pressure' because it is the highest.
  • the blood vessel pressure is called 'diastolic blood pressure', and it is called 'low blood pressure' because it is the lowest.
  • Normal blood pressure is 120 mmHg systolic and 80 mmHg diastolic. More than 1 in 4 Korean adults has high blood pressure, and after the age of 40, this ratio rapidly increases. Conversely, some patients are classified as hypotensive.
  • the high blood pressure is a problem because, if left uncontrolled without proper management of high blood pressure, it can cause other complications that can be life-threatening, such as eye disease, kidney disease, arterial disease, brain disease, and heart disease. In patients at risk for or with complications, continuous blood pressure measurement and management should be performed.
  • Blood pressure measurement methods include auscultation (Korotkoff sounds) method, oscillometric method, and tonometric method.
  • the auscultation method is a typical pressure measurement method, and in the process of applying sufficient pressure to a body part through which arterial blood passes to block the blood flow and then decompressing the pressure, the pressure at the moment when a pulse is first heard is measured as systolic pressure. It is a method of measuring the pressure at the moment the pulse sound disappears as the diastolic pressure.
  • the oscillometric method and the tonometric method are methods applied to a digitized blood pressure measuring apparatus.
  • the pulse wave generated in the process of decompressing the body part through which the arterial blood passes so as to block the blood flow of the artery sufficiently and then decompressing the body part at a constant rate, or in the process of pressurizing the body part to increase the pressure at a constant rate, like the auscultation method It measures systolic and diastolic blood pressure.
  • the pressure when the amplitude of the pulse wave is at a certain level compared to the moment when the amplitude is maximum may be measured as the systolic or diastolic blood pressure, and the pressure when the rate of change of the pulse wave amplitude is rapidly changed is measured as the systolic or diastolic blood pressure. You may.
  • the systolic blood pressure is measured before the moment when the amplitude of the pulse wave is maximum, and the diastolic blood pressure is measured later than the moment when the amplitude of the pulse wave is maximum.
  • the systolic blood pressure is measured later than the moment when the amplitude of the pulse wave is maximum, and the diastolic blood pressure is measured before the moment when the amplitude of the pulse wave is maximum.
  • the tonometric method is a method in which a predetermined pressure of a size that does not completely block arterial blood flow is applied to a body part, and the blood pressure can be continuously measured using the size and shape of the generated pulse wave.
  • a device for measuring blood pressure in various ways that is, a blood pressure monitor, is the most basic medical device for measuring blood pressure, which is the basis of a health index. It is widely used to measure blood pressure.
  • Most of the currently used blood pressure monitors are designed to measure blood pressure on the upper arm, which is similar to the height of the heart.
  • the above-described wrist blood pressure monitor or finger blood pressure monitor is smaller in size than the upper arm blood pressure monitor, so it is convenient to carry and easy to measure at any time.
  • an oscillometric blood pressure monitor detects multiple arterial pulses and measures blood pressure, it takes more than 40 seconds to measure blood pressure.
  • the present invention relates to a blood pressure monitor for measuring blood pressure, and an object of the present invention is to provide a blood pressure measuring system capable of quickly calculating a blood pressure value by detecting two types of arterial waves, and a blood pressure measuring method using the same.
  • One aspect of the present invention includes: a sensor unit for detecting a human arterial wave and a variable pressure arterial wave; and a blood pressure calculator configured to calculate a blood pressure value by using the human body arterial wave and the variable pressure arterial wave detected by the sensor unit, wherein the sensor unit is configured to detect the variable pressure arterial wave.
  • a blood pressure measurement system capable of detecting a pulse wave at a site where this is applied.
  • a sensor unit capable of detecting an arterial wave from one part of the human body and detecting a variable pressure arterial wave from another part to which the fluctuating pressure is applied;
  • a blood pressure measurement system including a blood pressure calculator configured to calculate a blood pressure value by using the human body arterial wave and the variable pressure arterial wave detected by the sensor unit.
  • the sensor unit may simultaneously measure the human body arterial wave and the variable pressure arterial wave at different positions.
  • the sensor unit includes a first sensor for detecting the arterial wave of the human body, and a second sensor for detecting the variable pressure arterial wave at a position different from that of the first sensor.
  • the second sensor may be configured as a pressure sensor. More specifically, an air pressure sensor may be applied as the second sensor. The second sensor may detect the variable pressure arterial wave at a position different from that of the first sensor.
  • the sensor unit may include a first sensor for detecting the human arterial wave below the diastolic blood pressure, and a second sensor for detecting the variable pressure arterial wave having a pulse wave equal to or greater than the diastolic blood pressure.
  • the blood pressure measurement system may further include a pulse wave processing unit configured to calculate a relative ratio value of the change amount of the variable pressure arterial wave to the change amount of the human body arterial wave measured by the sensor unit.
  • the blood pressure calculator may calculate the blood pressure value using the relative ratio value.
  • the highest value of the relative ratio value may be set as the highest fluctuating pressure value, and the systolic blood pressure and the diastolic blood pressure may be determined based on the highest fluctuating pressure value.
  • the blood pressure measurement system may further include a pulse wave processor configured to calculate a mapped arterial wave by mapping the human arterial wave to the variable pressure arterial wave measured by the sensor unit.
  • the blood pressure calculator may calculate the blood pressure value using the mapped arterial wave.
  • the mapped arterial wave may be calculated by mapping the human arterial wave to a predetermined position based on the deformation time of the variable pressure arterial wave.
  • the blood pressure measurement system may further include a pressing device for applying the fluctuation pressure to the measurement site of the fluctuation pressure arterial wave.
  • the pressurizing device is capable of raising or lowering the pressure in order to generate the fluctuating pressure; the sensor unit;
  • the variable pressure arterial wave may be sensed, ie, measured, during pressure increase or decompression by the pressure device.
  • the pressurizing device may include one or more selected from the group consisting of a compression band, an air bag, a tightening device, a thermal expansion material, a shape-changing alloy, a hole, a solenoid valve, and an air pump.
  • the pressing device may be implemented by one or a suitable combination of two or more of a compression band, an air bag, a tightening device, a thermally expandable material, a shape-changing alloy, a hole, a solenoid valve, and an air pump.
  • the sensor unit may include a sensor selected from the group consisting of a pressure sensor, an optical sensor, and an impedance sensor for measuring the impedance of blood vessels.
  • the implementation of the sensor unit may be applied to at least one sensor such as a pressure sensor, an optical sensor, and an impedance sensor for measuring the impedance of blood vessels.
  • the pressure sensor may include a sensor selected from the group consisting of a pneumatic pressure sensor, a film type pressure sensor, a strain gauge, and the like.
  • the sensor unit includes a first sensor and a second sensor capable of detecting arterial waves at different sites, respectively, and any one of the first sensor and the second sensor detects the variable pressure arterial wave at a site under variable pressure. It can be applied as a measuring sensor.
  • the sensor unit for example, the first sensor may measure the human arterial wave at a site under isobaric pressure.
  • Another aspect of the present invention provides a blood pressure measurement method using a blood pressure measurement system having a sensor unit for detecting an arterial wave, wherein a processor for calculating blood pressure includes a human arterial wave and a variable pressure artery detected by the sensor unit.
  • a blood pressure measurement method including a blood pressure calculation step of calculating blood pressure using waves.
  • the blood pressure measuring method may further include a pulse wave detecting step of detecting the human arterial wave and the variable pressure arterial wave using the sensor unit.
  • the pulse wave detecting step the human arterial wave and the variable pressure arterial wave may be simultaneously detected, that is, in the same time period.
  • a pulse wave processing step of calculating a relative ratio value of the variation amount of the variable pressure arterial wave to the variation amount of the human body arterial wave measured by the sensor unit may be performed;
  • the blood pressure calculation step may include calculating the blood pressure value using the relative ratio value.
  • the step of calculating the blood pressure may include; and setting a maximum value of the relative ratio value as a maximum fluctuation pressure value, and determining a systolic blood pressure and a diastolic blood pressure based on the maximum fluctuation pressure value.
  • a pulse wave processing step of calculating the mapped arterial wave by mapping the human body arterial wave to the variable pressure arterial wave measured by the sensor unit may be performed;
  • the calculating of the blood pressure may include calculating the blood pressure value using the mapped arterial wave.
  • the processing of the pulse wave may include calculating the mapped arterial wave by mapping the other arterial wave to a predetermined position based on the time of deformation of the variable pressure arterial wave.
  • the blood pressure measurement method may further include a pressure change step for adjusting a pressing force on a portion where the variable pressure arterial wave is measured while the variable pressure arterial wave is measured by the sensor unit.
  • the present invention can calculate and output a blood pressure value from a human arterial wave detected from one part of the body and an arterial wave detected from another part of the body to which a variable pressure is applied (variable pressure arterial wave), so the conventional oscillometric method Compared to a blood pressure monitor that takes 40 seconds or more to measure the blood pressure, it is possible to calculate the blood pressure more quickly to calculate an accurate blood pressure value, thereby significantly reducing the time required for calculating the blood pressure.
  • the blood pressure value can be calculated through an easy and simple process using the relative ratio values or mapping arterial waves obtainable from two waveforms consisting of the human arterial wave and the variable pressure arterial wave, so a complex blood pressure calculation algorithm This is not required.
  • FIG. 1 is a block diagram showing the configuration of a blood pressure measurement system according to the present invention.
  • FIG. 2 is a view schematically showing an embodiment of a blood pressure measurement system according to the present invention
  • FIG. 3 is a view showing a blood pressure measurement method by the blood pressure measurement system shown in FIG. 2 ;
  • FIG. 4 is a view schematically showing another embodiment of the blood pressure measurement system according to the present invention.
  • FIG. 5 is a view showing a blood pressure measurement method by the blood pressure measurement system shown in FIG. 4;
  • FIG. 6 is a diagram schematically showing another embodiment of a blood pressure measurement system according to the present invention.
  • FIG. 7 is a view showing a blood pressure measurement method by the blood pressure measurement system shown in FIG. 6;
  • FIG. 8 is a diagram schematically showing another embodiment of a blood pressure measurement system according to the present invention.
  • FIG. 9 is a view schematically showing another embodiment of the blood pressure measurement system according to the present invention.
  • FIG. 10 is a diagram schematically showing another embodiment of a blood pressure measurement system according to the present invention.
  • FIG. 11 is a flowchart schematically illustrating an embodiment of a method for measuring blood pressure according to the present invention.
  • FIG. 12 is a graph for explaining an embodiment of a method for measuring blood pressure according to the present invention.
  • FIG. 13 is a flowchart schematically illustrating another embodiment of a method for measuring blood pressure according to the present invention.
  • FIG. 14 is a graph for explaining another embodiment of the method for measuring blood pressure according to the present invention.
  • a component when it is said that a component is "connected” or “connected” to another component, it may be directly connected or connected to the other component, but a connection in which another component exists in the middle. It should be understood to include a relationship, that is, a relationship that is indirectly connected.
  • embodiments of the present invention provide a sensor unit 100 for detecting a sanche arterial wave such as a human arterial wave and a variable pressure arterial wave, and a signal detected by the sensor unit 100, that is,
  • the present invention relates to a blood pressure measuring system including a blood pressure calculating unit 200 for calculating blood pressure from the above-described human arterial wave and variable pressure arterial wave, and a blood pressure measuring method using the same.
  • the sensor unit 100 for an embodiment of the blood pressure measurement system according to the present invention has a configuration capable of detecting a pulse wave at a site to which a fluctuating pressure is applied for detecting the variable pressure arterial wave, that is, a site under the fluctuating pressure. It is a component that can detect variable pressure arterial waves in
  • the sensor unit 100 of the blood pressure measurement system can detect an arterial wave from one part of the human body, and a variable pressure from another part to which the fluctuating pressure is applied. It is a biosignal detector that can detect arterial waves.
  • the blood pressure calculating unit 200 is a component that calculates a blood pressure value by using the signals (human arterial wave and variable pressure arterial wave) detected by the sensor unit 200 .
  • the sensor unit 100 may simultaneously measure the above-described human arterial wave and variable pressure arterial wave at different positions.
  • the sensor unit 100 may include a first sensor 110 for detecting the above-described human arterial wave and a second sensor 120 for detecting the variable pressure arterial wave,
  • the second sensor 120 measures a biosignal, that is, the above-described variable pressure arterial wave at a position different from that of the first sensor 110 .
  • the first sensor 110 and the second sensor 120 simultaneously measure the aforementioned arterial wave (human arterial wave) and variable pressure arterial wave at different positions of the body, respectively.
  • the first sensor 110 detects an arterial wave in a region under isobaric pressure, more specifically, in a region to which a constant pressure is applied.
  • the second sensor 120 detects the aforementioned variable pressure arterial wave at a location different from that of the first sensor 110 .
  • the second sensor 120 detects the above-described variable pressure arterial wave at a portion to which the variable pressure is applied, that is, a portion to which an external force is changed.
  • the sensor unit 100 measures one arterial wave at a site under isobaric pressure, and measures the other variable pressure arterial wave at a site under variable pressure, that is, a pressure change environment. That is, the sensor unit 100 is capable of detecting the above-described human arterial wave at a site under isobaric pressure (eg, at a site under constant pressure or on which external force is not applied), and can detect the above-described human arterial wave at a site under fluctuating pressure. It is possible to detect variable pressure arterial waves.
  • the arterial wave and the variable pressure arterial wave may be simultaneously detected by the first sensor 110 and the second sensor 120 described above, that is, at the same time period.
  • the human arterial wave and the variable pressure arterial wave may be sequentially measured at the same location.
  • the sensor unit 100 includes a first sensor 110 and a second sensor 120 capable of detecting arterial waves at different sites, respectively, and any one of the first sensor and the second sensor One may measure the variable pressure arterial wave at a site under variable pressure.
  • the variable pressure arterial wave detection sensor is applied as the second sensor 120 .
  • the arterial wave (human arterial wave) may be measured below diastolic blood pressure, and the variable pressure arterial wave may include a pulse wave equal to or greater than diastolic blood pressure.
  • the human arterial wave may be a pulse wave measured in a state where the external pressure applied to the artery is equal to or less than the diastolic blood pressure, for example, a pulse wave measured in a state in which the arterial wave is not deformed by the external pressure.
  • the variable pressure arterial wave may be a pulse wave measured in a state in which the external pressure applied to the artery is equal to or greater than the diastolic blood pressure, for example, a pulse wave measured in a state in which the arterial wave is deformed by the external pressure.
  • an optical sensor such as a pressure sensor and an optical blood flow meter (PPG sensor) and a sensor such as an impedance sensor for measuring the impedance of blood vessels may be applied.
  • the pressure sensor may include at least one of an air pressure sensor, a film pressure sensor, and a strain gauge. Since the above-described sensors themselves are known, an additional description thereof will be omitted.
  • the blood pressure calculation unit 200 calculates a blood pressure value using a relative ratio value or a mapped arterial wave, as will be described later.
  • the blood pressure measurement system includes a pulse wave processing unit 300 that calculates the above-described relative ratio value or mapped arterial wave from the arterial wave (human arterial wave) and the variable pressure arterial wave. do.
  • the pulse wave processing unit 300 may calculate a ratio value of the change amount of the variable pressure arterial wave to the change amount of the human arterial wave measured by the sensor unit 100 , that is, the above-described relative ratio value.
  • the blood pressure calculator 200 may calculate a blood pressure value using the above-described relative ratio value.
  • the blood pressure calculator 200 may set the maximum value of the relative ratio value as the maximum fluctuation pressure value, and determine the systolic blood pressure and the diastolic blood pressure based on the maximum fluctuation pressure value.
  • the pulse wave processing unit 300 may calculate the above-described mapped arterial wave by mapping the human arterial wave to the variable pressure arterial wave measured by the sensor unit 100 .
  • the blood pressure calculator 200 may calculate the blood pressure value using the mapped arterial wave.
  • the pulse wave processing unit 300 may calculate the mapped arterial wave by mapping the human body arterial wave to the variable pressure arterial wave based on the time point at which the variable pressure arterial wave is deformed.
  • the blood pressure measurement system 10 is a pressurizing device for applying a variable pressure to the portion where the variable pressure arterial wave is measured, that is, the portion where the signal is detected by the second sensor 120 (the measurement location of the second sensor described above). (400) may be further included.
  • variable pressure may be implemented manually while the examinee pressurizes or presses the measurement site by the second sensor 120 by himself/herself, and the variable pressure is automatically implemented by the above-described pressurizing device 400 . This may be implemented.
  • the pressurization device 400 is capable of increasing the pressure (increasing the pressing force on the part to be inspected) or reducing the pressure (reducing the pressing force on the inspected part) in order to generate the above-described fluctuating pressure, and the sensor unit 100, especially the first
  • the second sensor 120 detects the above-described variable pressure arterial wave during pressure increase or decompression of the part to be inspected (measured position of the second sensor) by the pressure device 400 .
  • the pressing device 400 includes a compression band that presses the to-be-tested part, and a tightener (for example, Patent Publication Nos. 10-2018-0019325 and 10-2017-0042118) for clamping the part to be tested (a detection site of a variable pressure arterial wave).
  • a tightener for example, Patent Publication Nos. 10-2018-0019325 and 10-2017-0042118
  • clamping the part to be tested a detection site of a variable pressure arterial wave.
  • air bag 410, refer to the drawings of embodiments to be described later
  • air pump thermal expansion material
  • shape-changing alloy such as shape memory alloy, etc. It may include any one configuration or configurations by a combination thereof.
  • the pressurizing device 400 may be provided with a valve (not shown) for opening and closing a passage for guiding air to the air bag 410 and an exhaust port (exhaust hole) for discharging air of the air bag. have.
  • the second sensor 120 measures the variable pressure 2 arterial wave described above during the pressure increase or decompression process of the part to be tested by the pressure device 400 .
  • the second sensor 120 may measure the variable pressure arterial wave while the part to be tested is pressurized or depressurized at a constant rate by the pressurizing device 400 .
  • the air bag 410 that presses the part to be inspected (measured position of the second sensor) is gradually expanded by the air supply action of the air pump, or is gradually exhausted from the air bag 410 inflated by the air pump. During discharge), the variable pressure arterial wave is measured by the second sensor 120 .
  • the pulse wave processing unit 300 when the human arterial wave is detected by the first sensor 110 and the variable pressure arterial wave is detected by the second sensor 120 , the pulse wave processing unit 300 generates the human arterial wave and the variable pressure arterial wave. A relative ratio value or a mapped arterial wave is obtained using the wave, and the blood pressure calculating unit 200 calculates a blood pressure value from the above-described relative ratio value or the mapped arterial wave.
  • the blood pressure calculating unit 200 determines the maximum variable pressure value based on the maximum value of the relative ratio value. In addition, the blood pressure calculator 200 determines a systolic blood pressure and a diastolic blood pressure based on the maximum fluctuating pressure value.
  • the blood pressure calculator 200 calculates the arterial wave deformation time point (time points a and b in the graph shown at the top of FIG. 14 ) when the variable pressure arterial wave is measured.
  • the human body arterial wave is mapped as a reference to calculate the mapped arterial wave, and the blood pressure is calculated using the above-described mapped arterial wave. More specifically, the blood pressure calculator 200 determines the highest value of the mapped arterial wave as the systolic blood pressure, and determines the lowest value of the mapped arterial wave as the diastolic blood pressure.
  • the sensor unit 100 that is, the first sensor 110 and the second sensor 120 is controlled by a processor, that is, the control unit C, and the pressurizing device 400 is also controlled by the above-described control unit C.
  • a processor that is, the control unit C
  • the pressurizing device 400 is also controlled by the above-described control unit C.
  • filling and exhausting of the air bag to be described later may be performed.
  • the blood pressure values calculated in the above-described manner for example, the systolic blood pressure and the diastolic blood pressure, are displayed on the blood pressure output unit 500 such as a digital monitor.
  • FIGS. 2 to 10 Specific embodiments of the blood pressure measurement system according to the present invention will be described with reference to FIGS. 2 to 10 .
  • the first embodiment 10 of the blood pressure measurement system is a blood pressure monitor that detects arterial signals, ie, human arterial waves and variable pressure arterial waves, from a finger.
  • the first sensor Reference numeral 110 is an optical sensor, and the above-described second sensor 120 is an example of a film-type pressure sensor.
  • the first sensor 110 may be disposed on the finger pad 101 .
  • the examinee places the fingers F1 and F2 on the portion where the first sensor 110 (optical sensor) is disposed and the portion where the second sensor 120 (film-type pressure sensor) is disposed, respectively.
  • a single finger F1 is raised and brought into contact with a constant pressure, and the pressure is increased while gradually pressing the finger F2 placed on the portion where the second sensor 120 (film-type pressure sensor) is disposed.
  • the first sensor 110 detects a human arterial wave
  • the second sensor 120 detects a variable pressure arterial wave under a variable pressure.
  • the finger pad 101 may be provided in a band type that can be wound around a finger to be fixed, and the second sensor 120 may also be fixed to the finger in a band type.
  • the second embodiment 10A of the blood pressure measurement system is also a blood pressure monitor that detects a signal of an artery from a finger, wherein the first sensor 110 is an optical sensor.
  • the above-described second sensor 120 is an example of an air pressure sensor, and the second sensor 120 is provided in the air bag 410 .
  • the first sensor 110 and the second sensor 120 may be fixed by being wound around a finger in a band type as in the above-described embodiment.
  • the examinee puts one finger (F1) in contact with the area where the first sensor 110 (optical sensor) is disposed, and uses the other finger (F2) to place the second sensor 120 (air pressure sensor) in the air bag 410 . Press . Exhaust is made in the air hole (not shown) of the air bag 410 while the examinee presses the air bag 410 with a finger F2 to a predetermined pressure, for example, a pressure of 300 mmHg, such an exhaust process , the detection of the variable pressure arterial wave is performed by the second sensor 120 (air pressure sensor).
  • a linear valve for controlling the flow rate may be provided in the air hole, that is, the exhaust hole of the air bag.
  • the relative ratio value or the mapping arterial wave is performed by the pulse wave processing unit 300 described above. is obtained, and the blood pressure calculator 200 calculates the blood pressure using the above-described relative ratio value or the mapped arterial wave.
  • a third embodiment 10B of the blood pressure measurement system according to the present invention is a brachial cuff type blood pressure monitor.
  • a second sensor 120 for detection is included, wherein the first sensor 110 is made of an optical sensor, and the second sensor 120 is an example of a pneumatic sensor.
  • the first sensor 110 and the second sensor 120 are provided on a cuff belt 600 worn on the upper arm. More specifically, the cuff belt 600 is provided with an air bag 410 , and the air bag 410 may be filled by a manual or automatic pumping mechanism (air pump). And the second sensor 120 , that is, the air pressure sensor is provided in the air bag 410 , and the first sensor 110 is affected by the pressure of the outer area of the air bag 410 , that is, the air bag 410 . It is placed in an area that does not receive it.
  • the air is pressed so that the subject's upper arm is pressed.
  • the pocket 410 is filled with air, and the portion measured by the first sensor 110, for example, at the height of the heart, is not subjected to pressure from the cuff belt 600 or a constant pressure, for example, is weak without a change in the tightening force. It is in a state of simple contact with the cuff belt by force, and the portion measured by the second sensor 120 is in a state of being pressed by the air bag 410 .
  • the pressure of the target part is gradually reduced at a certain rate by the exhaust of the air bag 410, and in this exhaust process, the first sensor 110 detects a human arterial wave (optical arterial wave), and at the same time, the Detection of the variable pressure arterial wave by the second sensor 120 (air pressure sensor) is performed.
  • a human arterial wave optical arterial wave
  • a relative ratio value or a mapped arterial wave is obtained by the pulse wave processing unit 300 described above, and the blood pressure calculating unit 200 . ) calculates the blood pressure using the above-described relative ratio value or the mapped arterial wave.
  • a fourth embodiment of the blood pressure measurement system is a wrist blood pressure monitor 10C, which includes the first sensor 110 for detecting human arterial waves and the detection of variable pressure arterial waves. It includes a second sensor 120 for, the first sensor 110 is made of an optical sensor, the second sensor 120 is an example made of a pneumatic sensor.
  • the first sensor 110 and the second sensor 120 are provided on a wrist cuff 700 worn on the wrist, that is, a wrist strap. More specifically, the wrist cuff 700 is provided with an air bag 410, and the air bag 410 may be filled by a manual or automatic pumping mechanism (air pump). And the second sensor 120 , that is, the air pressure sensor is provided in the air bag 410 , and the first sensor 110 is affected by the pressure of the outer area of the air bag 410 , that is, the air bag 410 . It is provided at the lower side of the case 710 for a display device (blood pressure output unit) that outputs a blood pressure value, for example, a portion that is not received.
  • the wrist cuff 700 is connected by a strap detachable means 720 such as a clasp (velcro), a button, or a buckle.
  • the wrist blood pressure monitor 10C After the above-described wrist blood pressure monitor 10C is worn on the wrist of the subject, air is placed in the air bag 410 up to a predetermined pressure so that the wrist of the subject is locally compressed (for example, compression of the area through which the radial artery or the ulnar artery passes). is filled Thereafter, the pressure is gradually reduced at a certain rate by the exhaust of the air bag 410, and in this exhaust process, the first sensor 110 detects a human arterial wave (optical arterial wave), and at the same time, the second sensor ( 120; detection of the variable pressure arterial wave by the pneumatic sensor) is performed.
  • a human arterial wave optical arterial wave
  • a relative ratio value or a mapping arterial wave is obtained by the pulse wave processing unit 300 described above, and the blood pressure calculating unit 200 . ) calculates the blood pressure using the above-described relative ratio value or the mapped arterial wave.
  • a fifth embodiment 10D of the blood pressure measurement system is a blood pressure measurement system implemented as a patient monitoring device, connected to a monitoring monitor 800 and separated from each other by an oxygen saturation meter ( 900) and the upper arm cuff 600, and the upper arm cuff 600 is provided with an air bag 410 and an air pressure sensor 120, that is, a second sensor.
  • the oxygen saturation meter 900 measures the arterial wave of the human body using a sensor for measuring oxygen saturation, for example, an optical sensor (first sensor; 110), and the upper arm cuff 600 is a belt worn on the subject's upper arm.
  • a sensor for measuring oxygen saturation for example, an optical sensor (first sensor; 110)
  • the upper arm cuff 600 is a belt worn on the subject's upper arm.
  • the variable pressure arterial wave is measured in the same manner as in the third embodiment described above by the air bag and the air pressure sensor provided in the upper arm cuff 600 , that is, the cuff belt. That is, in the present embodiment, the air bag and the second sensor are provided in the upper arm cuff 600 , but there is no first sensor, and the oxygen saturation meter functions as the first sensor.
  • a relative ratio value or a mapped arterial wave is obtained by the pulse wave processing unit 300 described above, and the blood pressure calculating unit 200 . ) calculates the blood pressure using the above-described relative ratio value or the mapped arterial wave.
  • a sixth embodiment 10E of the blood pressure measurement system according to the present invention is a brachial cuff type blood pressure monitor.
  • a second sensor 120 for detection is included, and the first sensor 110 and the second sensor 120 are each an example of a pneumatic sensor.
  • the first sensor 110 and the second sensor 120 are provided on a cuff belt 600 worn on the upper arm. More specifically, the cuff belt 600 is provided with a first air bag 410, and the first air bag 410 may be filled by a manual or automatic pumping mechanism (air pump). And the second sensor 120 , that is, the air pressure sensor is provided in the first air bag 410 , and the first sensor 110 is an external area of the first air bag 410 , that is, the pressure of the air bag 410 . It is provided in an area not affected by
  • a separate air bag that is, a second air bag 420 is provided in the cuff belt 600 , and the first sensor 110 is provided in the second air bag 420 .
  • the upper arm cuff type blood pressure monitor is worn on the subject's upper arm using a belt fixing means such as a Velcro 610 called a squeak or a button provided in the cuff belt 600, the upper arm of the subject is pressed.
  • Air is filled in the first air bag 410 and the second air bag 420.
  • the second air bag 420 may have a sealed structure by being filled with a predetermined amount of air in advance.
  • the portion measured by the first sensor 110 is pressed by the second air bag 420 at a predetermined pressure, and the second sensor 120 .
  • the measurement site by is in a state of being pressed by the first air bag (410).
  • the pressure of the target part (the measurement site of the second sensor) is gradually reduced at a certain rate by the exhaust of the first air bag 410, and the pressure of the second air bag 420 is maintained as well.
  • the first sensor 110 detects a human arterial wave (optical arterial wave)
  • the second sensor 120 air pressure sensor
  • a relative ratio value or a mapping arterial wave is obtained by the above-described pulse wave processing unit 300 , and the blood pressure calculating unit 200 . ) calculates the blood pressure using the above-described relative ratio value or the mapped arterial wave.
  • an embodiment of a blood pressure measurement method by a blood pressure measurement system having a sensor unit for detecting an arterial wave includes a processor that calculates blood pressure, that is, a control unit C, in particular, the above-described blood pressure calculation.
  • the unit 200 includes a blood pressure calculation step of calculating a blood pressure value using the human body arterial wave and the variable pressure arterial wave detected by the sensor unit 100 described above.
  • the step of calculating the blood pressure in the present embodiment includes calculating the blood pressure value using the above-described relative ratio value.
  • a pulse wave detection step of detecting the above-described human arterial wave and variable pressure at different positions of the human body by the above-described sensor unit 100 is performed.
  • the above-described human arterial wave and the detection of the fluctuating pressure are simultaneously performed in the same time period.
  • variable pressure arterial wave In the detecting of the pulse wave, the variable pressure arterial wave may be measured during a pressure increase or decompression process of a region where the variable pressure arterial wave is measured. More specifically, in the detecting of the pulse wave, the variable pressure arterial wave may be detected by detecting a pressure signal during a pressure increase or decompression process at a constant rate of a pressure in a region where the variable pressure arterial wave is measured.
  • the first embodiment of the method for measuring blood pressure according to the present invention is a pulse wave processing that calculates the ratio of the change amount of the variable pressure arterial wave to the change amount of the human arterial wave detected by the sensor unit 100, that is, the above-described relative ratio value. includes steps.
  • the pulse wave processing step that is, the calculation of the relative ratio value is performed before the blood pressure calculation step, and the step of calculating the blood pressure value using the above-described relative ratio value is performed in the blood pressure calculation step.
  • the highest value of the relative ratio value is used to determine the highest variable pressure value. Then, the systolic blood pressure and the diastolic blood pressure are determined on the basis of the maximum fluctuating pressure value to calculate the blood pressure value.
  • a signal measured by the above-described second sensor 120 for example, a variable pressure is converted into a pressure-to-variable pressure arterial wave, and the first sensor 110 measures an arterial wave by an optical signal. do.
  • the uppermost graph in the graph shown in FIG. 12 is a graph showing an arterial wave detected by the first sensor, that is, a human arterial wave.
  • the second graph from the top of FIG. 12 shows a variable pressure arterial wave detected by the second sensor in a fluctuating pressure environment, for example, a decompression process
  • the third graph from the top shows the amount of change in the arterial wave (the amount of change in the arterial wave of the human body,
  • it is a waveform graph showing a 'first change amount'
  • the fourth graph from the top is a waveform graph showing a change amount of the variable pressure arterial wave (hereinafter referred to as a 'second change amount').
  • the graph shown at the bottom of FIG. 12 is a graph showing the relative ratio value of the second change amount compared to the first change amount, that is, a waveform graph of the relative ratio value (relative ratio wave), and the largest value (the highest value) among the relative ratio values value) is the maximum fluctuating pressure value, and the values at the left and right constant points based on this value become the systolic and diastolic blood pressure values.
  • a relative ratio value is calculated (calculated) based on the human arterial wave and the variable pressure arterial wave, and the blood pressure calculation is performed using the relative ratio value.
  • t denotes time and P denotes pressure.
  • FIGS. 13 and 14 another embodiment (the second embodiment) of a blood pressure measurement method by a blood pressure measurement system having a sensor unit for detecting an arterial signal is a processor for calculating blood pressure, that is, a control unit.
  • C includes a blood pressure calculation step of calculating a blood pressure value using the human arterial wave and the variable pressure arterial wave, and more specifically, mapping the human arterial wave to the signal measured under the fluctuating pressure, that is, the variable pressure arterial wave. An arterial wave is calculated, and a blood pressure value is calculated using the mapped arterial wave.
  • the step of calculating the blood pressure in this embodiment includes calculating the blood pressure value using the above-described mapped arterial wave.
  • a pulse wave detection step of detecting the above-described human arterial wave and variable pressure at different positions of the human body by the above-described sensor unit 100 is performed.
  • the above-described human arterial wave and the detection of the fluctuating pressure are simultaneously performed in the same time period.
  • variable pressure arterial wave In the detecting of the pulse wave, the variable pressure arterial wave may be measured during a pressure increase or decompression process of a region where the variable pressure arterial wave is measured. More specifically, in the detecting of the pulse wave, the variable pressure arterial wave may be detected by detecting a pressure signal during a pressure increase or decompression process at a constant rate of a pressure in a region where the variable pressure arterial wave is measured.
  • a second embodiment of the method for measuring blood pressure according to the present invention includes a pulse wave processing step of calculating the mapped arterial wave by mapping the human arterial wave to the variable pressure arterial wave detected by the sensor unit 100 .
  • the pulse wave processing step that is, the calculation of the mapped arterial wave is performed before the blood pressure calculation step, and the step of calculating the blood pressure value using the above-described mapped arterial wave is performed in the blood pressure calculation step.
  • the calculation of the mapping arterial wave is performed based on a deformation time point (deformation time) of the variable pressure arterial wave when the variable pressure arterial wave is measured.
  • the human arterial wave measured under isostatic pressure for example, an artery detected by an optical sensor
  • a blood pressure value is calculated using the above-described mapped arterial wave.
  • the highest value of the mapped arterial wave is determined as the systolic blood pressure, and the lowest value of the mapped arterial wave is determined as the diastolic blood pressure.
  • the signal measured by the above-described second sensor 120 for example, the arterial pressure of the site to be tested is converted into a pressure-varying arterial wave with respect to the pressure, and in the first sensor 110, the artery at a constant pressure.
  • the wave that is, the human arterial wave is measured.
  • the uppermost graph in the graph shown in FIG. 14 is the pressure measured by the second sensor, such as the above-described air pressure sensor, during the pressure increase process, for example, in the process of filling the air bag with air, the pressure of the air bag itself and It is a graph in which the pressure of blood vessels is reflected together, and points a and b are the time points at which the variable pressure arterial wave is deformed.
  • the second sensor such as the above-described air pressure sensor
  • the second graph from the top of FIG. 14 is a graph showing a signal measured by the first sensor, that is, a human arterial wave.
  • the graph shown at the bottom of FIG. 14 is a graph showing the above-described mapping arterial wave, and the human arterial wave is located at a and b at the time points a and b at which the variable pressure arterial wave of the uppermost graph (variable pressure arterial wave graph) is modified. It is a graph showing the human arterial wave graph superimposed on the variable pressure arterial wave graph so that it overlaps with the same time point (points c and d) of the graph of (the second graph from the top). In these mapped sinus waves, the highest value is determined as the systolic blood pressure, and the lowest value of the mapped arterial wave becomes the diastolic blood pressure. For reference, when mapping two arterial waves, the amplitude of the human arterial wave is adjusted so that the c and d points of the human arterial wave are accurately superimposed on the a and b points of the variable pressure arterial wave.
  • the blood pressure calculation can be performed using the mapping arterial wave and the relative ratio values obtained based on the above-described two biosignals, particularly the human arterial wave and the variable pressure arterial wave.
  • the deformation time point of the variable pressure arterial wave is used.
  • the present invention relates to a blood pressure measuring device and a blood pressure measuring method for measuring blood pressure in a human body, and is applicable to the medical device field, particularly the blood pressure monitor-related technical field.

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