WO2021177065A1

WO2021177065A1 - Composition for oral cavity

Info

Publication number: WO2021177065A1
Application number: PCT/JP2021/006558
Authority: WO
Inventors: 高橋　雅人; 飯島　浩; 理加小田; 松田　賢治
Original assignee: ライオン株式会社
Priority date: 2020-03-02
Filing date: 2021-02-22
Publication date: 2021-09-10
Also published as: JPWO2021177065A1

Abstract

Provided is a composition for the oral cavity in which bitterness is suppressed and the taste is good, and which allows berberine contained in Phellodendron amurense extract to penetrate to the connective tissue layer and exert a preventative or ameliorating effect on periodontal disease.　A composition for the oral cavity that contains (A) 0.02-0.5 mass% of Phellodendron amurense extract as a powder extract, (B) 0.5-3 mass% of sodium alkyl sulfate, and (C) 0.2-2 mass% of polyoxyethylene hydrogenated castor oil having an average number of added mol of ethylene oxide of 3-7 mol, (C)/(A) being 1-20 as a mass ratio and (B)/(C) being 1.2-3.5 as a mass ratio. The composition for the oral cavity also contains (D) 0.01-1 mass% of isopropyl methyl phenol.

Description

Oral composition

The present invention relates to an oral composition in which berberine contained in Phellodendron amur extract penetrates into the connective tissue layer in the gingiva and exerts a preventive or ameliorating effect on periodontal disease.

Oubaku extract containing berberine as an active ingredient (plant extract of Rutaceae containing Phellodendron amur (Phellodendron amurensis)) is an ingredient having an excellent effect of preventing or improving periodontal disease, and is an oral composition such as a dentifrice composition. When blended in, anti-inflammatory and antibacterial effects can be expected. Furthermore, it has been reported that berberine contained in Phellodendron amur extract acts on macrophages to suppress osteoclast formation (osteoclast differentiation inhibitory effect) (Non-Patent Document 1). Therefore, it was expected that this function could prevent or ameliorate the periodontal disease more effectively by preventing the alveolar bone from being destroyed by the overformation of osteoclasts due to the inflammation associated with the periodontal disease. In the oral composition, it is technically difficult to infiltrate velberin into the gingival connective tissue layer in which macrophages in the gingival epithelium are present, and the above function could not be satisfactorily expressed.

By the way, it is known that the stability of berberine is improved by adding the nonionic surfactant polyoxyethylene hydrogenated castor oil to the oral composition containing berberine. In Patent Document 1 (Japanese Unexamined Patent Publication No. 8-179541), a toothpaste composition containing polyoxyethylene hydrogenated castor oil having an average addition molar number of ethylene oxide of 20 or more is stored at 50 ° C. for 3 months. It is disclosed that velverin remains at a high rate, and Patent Documents 2 to 4 (Japanese Patent Laid-Open Nos. 2012-92042, 2012-158559, and 2011-132137) are also blended in the dentifrice composition. Polyoxyethylene hydrogenated castor oil is used to improve the storage stability of the velverin. Patent Document 5 (Japanese Unexamined Patent Publication No. 2005-187329) proposes that when berberine is blended with condensed phosphate and polyoxyethylene hydrogenated castor oil, irritation can be suppressed and the storage stability of berberine can be improved. There is. However, neither document pays attention to the permeability of berberine into the gingival tissue, and the conventional technique can enhance the permeability of berberine into the gingival tissue to reach and penetrate the connective tissue layer. There wasn't.

Japanese Unexamined Patent Publication No. 8-175941 Japanese Unexamined Patent Publication No. 2012-92042 Japanese Unexamined Patent Publication No. 2012-158559 Japanese Unexamined Patent Publication No. 2011-132137 Japanese Unexamined Patent Publication No. 2005-187329

The present invention has been made in view of the above circumstances, and is an oral composition in which berberine contained in Phellodendron amurensis extract reaches and permeates the binding tissue layer in the gingiva and effectively prevents or ameliorate the periodontal disease. The purpose is to provide things.

As a result of diligent studies to achieve the above object, the present inventors have specified a specific amount of a specific anionic surfactant and a specific nonionic surfactant in an oral composition containing a specific amount of Phellodendron amur extract. When combined in proportion, the permeability of berberine contained in Phellodendron amur extract to the gingival tissue is enhanced, and berberine can reach and permeate the connective tissue layer in the gingival epithelium, and is derived from Phellodendron amur extract. It was found that the bitterness can be suppressed and a good feeling of use can be ensured. That is, in the present invention, (A) gingival extract is 0.02 to 0.5% by mass, (B) sodium alkyl sulfate is 0.5 to 3% by mass, and (C) the average number of moles of ethylene oxide added is 3. About 7 mol of polyoxyethylene hydrogenated gum oil was blended in an amount of 0.2 to 2% by mass, and (C) / (A) had a mass ratio of 1 to 20 and (B) / (C) had a mass ratio of 1. When the content is 2 to 3.5, the permeability of velverine contained in the component (A) into the gingival tissue is enhanced, and the permeation into the gingival tissue layer in the gingiva is effective, and the effect of preventing or improving periodontal disease is effective. It has been found that an oral composition having a good taste can be provided, and the present invention has been made.

More specifically, when the present inventors focused on an anionic surfactant which is said to contribute to the permeability of the water-soluble active ingredient, the oral cavity containing (A) Phellodendron amur extract was examined. By blending (B) sodium alkylsulfate among the anionic surfactants in the composition for use, the permeability of berberine contained in the component (A) into the gingival tissue could be improved to some extent. On the other hand, the combined use of the component (B) amplifies the unique bitterness derived from the component (A), which deteriorates the taste and causes a problem that it is not suitable for use. If a nonionic surfactant is added inappropriately for masking the unique bitterness, the function of the component (B) for berberine is inactivated, and the permeability of berberine to the gingival tissue is not improved. rice field. However, when (C) specific polyoxyethylene hydrogenated castor oil among nonionic surfactants is blended in combination with (B) component, the amount of each component is in a specific range and the mass of (C) / (A). Within a specific range of the ratio and the mass ratio of (B) / (C), the components (B) and (C) interact with each other, whereby the component (A) is subjected to the combined system of the specific surfactant. It was possible to reach and permeate the connective tissue layer in the gingival epithelium with velverin contained in the component (A) while suppressing the peculiar bitterness of the origin without amplifying it and maintaining the good taste.
Therefore, in the oral composition of the present invention, not only the anti-inflammatory action and antibacterial action of velverin contained in the component (A), but also velverin acts on macrophages of the gingival connective tissue layer to suppress osteoclast formation. It is also possible to prevent bone destruction due to abnormal activation of osteoclasts by a function (osteoclast differentiation inhibitory action), and it is possible to more effectively provide a preventive or inhibitory effect on periodontal disease.
As shown in Examples described later, the components (A), (B) and (C) of the present invention are in a specific amount, and the mass ratio of (C) / (A) and the mass ratio of (B) / (C). In the oral composition in which each of the above is blended within a specific range, velverin reaches and penetrates into the gingival connective tissue layer, and the reachability of velverine to the gingival connective tissue (reaching to the gingival connective tissue layer, degree of penetration). Was excellent, and the feeling of use (no bitterness) was also good. On the other hand, as shown in the comparative example described later, if the mass ratio of (C) / (A) or the mass ratio of (B) / (C) is inappropriate, velverin reaches the gingival connective tissue. In Comparative Examples 3 and 9 in which the sex or usability (no bitterness) was poor (Comparative Examples 2 to 4, 7, 9, and 10), and the mass ratio of (B) / (C) was too small, the gingival bond of velverin was obtained. It had poor reach to the tissue and did not penetrate into the connective tissue layer. Further, when the anionic surfactant sodium lauroylmethyltaurine was blended in place of the component (B), the reachability of velverine to the gingival connective tissue was poor (Comparative Example 11), and the component (C) was replaced. When polyoxyethylene hydrogenated castor oil having an average number of added moles of ethylene oxide exceeding 7 was blended, the reachability of velverine to the gingival connective tissue was poor (Comparative Examples 5, 6 and 8).

Therefore, the present invention provides the following oral compositions.
[1]
(A) 0.02 to 0.5% by mass of Phellodendron amur extract as a powder extract,
(B) 0.5 to 3% by mass of sodium alkyl sulfate
And (C) 0.2 to 2% by mass of polyoxyethylene hydrogenated castor oil having an average number of moles of ethylene oxide added of 3 to 7 mol.
An oral composition containing 1 to 20 by mass ratio of (C) / (A) and 1.2 to 3.5 by mass ratio of (B) / (C).
[2]
(A) The oral composition according to [1], wherein the Phellodendron amur extract has a berberine content of 3% by mass or more in the powder extract.
[3]
The oral composition according to [1] or [2], which further contains (D) isopropylmethylphenol in an amount of 0.01 to 1% by mass.
[4]
The oral composition according to any one of [1] to [3], which is a dentifrice composition.

According to the present invention, the permeability of berberine contained in the component (A) into the gingival tissue is enhanced, and the berberine reaches and penetrates into the connective tissue layer in the gingiva, effectively preventing or improving the periodontal disease. It is possible to provide an oral composition in which bitterness is suppressed and the taste is good. In addition to the anti-inflammatory and antibacterial effects of velverine, the oral composition of the present invention can also prevent bone destruction due to abnormal activation of osteoclasts by suppressing osteoclast differentiation, and thus periodontal disease. It is effective for prevention or improvement of.

Hereinafter, the present invention will be described in more detail. The oral composition of the present invention comprises (A) Oubaku extract, (B) sodium alkyl sulfate, and (C) polyoxyethylene hydrogenated castor oil having an average addition molar number of 3 to 7 moles in specific amounts. The mass ratios of (C) / (A) and (B) / (C) are in a specific range.

(A) Phellodendron amur extract contains berberine as an active ingredient, and berberine has anti-inflammatory and antibacterial effects, and also has an osteoclast differentiation inhibitory effect by acting on macrophages to prevent periodontal disease. Or give a suppressive effect.
The Oubaku extract is a solvent extract of a plant such as Rutaceae containing Phellodendron amur (Phellodendron amurensis), and one obtained by a known method can be used.
The Phellodendron amur extract may be in a liquid state, may be in a dried solid state, or may be a powdered powder extract.
Specifically, the bark of a Rutaceae plant such as Phellodendron amur can be used as the raw material.
As the extraction solvent, a hydrophilic solvent can be used, and examples thereof include water, lower monohydric alcohols such as ethanol and propanol, and hydrophilic solvents such as polyhydric alcohols such as 1,3-butylene glycol and propylene glycol, and are selected from these. A single solvent of the species or a mixed solvent of two or more species can be used. Normal methods can be used for extraction conditions and post-processing.
As the Phellodendron amur extract, the Phellodendron amur extract listed in the quasi-drug raw material standard and the Phellodendron amur powder listed in the pharmaceutical additive standard can be used, and commercially available products can be used, but particularly in the powder extract. The berberine content is preferably 3% (mass%, the same applies hereinafter), more preferably 5% or more, and particularly preferably 5 to 7%, from the viewpoint of exhibiting the effects of the present invention.
As a commercial product of such Oubaku extract, specifically, as a powder extract obtained by extracting the bark of Phellodendron amur with hot water and spray-drying it, a trade name manufactured by Koshiro Pharmaceutical Co., Ltd .; Examples of the liquid extract contained include a trade name manufactured by Maruzen Pharmaceuticals Co., Ltd .; Phellodendron amur extract-J and the like.

The blending amount of (A) Phellodendron amur extract is 0.02 to 0.5% of the entire composition as a powder extract, and 0.02 to 0.2% is particularly preferable. If the blending amount of the component (A) is less than 0.02%, the reachability of berberine to the gingival connective tissue is poor, and if it exceeds 0.5%, the bitterness due to itself is too strong and the taste deteriorates.
Further, the blending amount of (A) Phellodendron amur extract is preferably 0.001 to 0.025%, more preferably 0.0025 to 0.01% of the whole composition as berberine, and is within this range. The reach of berberine to the gingival connective tissue is sufficient, and the bitterness is sufficiently suppressed.

(B) Sodium alkyl sulfate promotes the penetration of berberine contained in the component (A) into the gingival tissue, and has the effect of reaching and penetrating berberine into the gingival connective tissue layer.
(B) Sodium alkyl sulfate preferably has an alkyl group having a carbon chain length of 8 to 18, particularly 10 to 16, and examples thereof include sodium lauryl sulfate and sodium myristyl sulfate. Commercially available products such as those manufactured by BASF Japan Ltd. can be used.
The blending amount of (B) sodium alkyl sulfate is 0.5 to 3%, preferably 0.7 to 2% of the total composition. If the blending amount is less than 0.5%, the reachability of berberine to the gingival connective tissue is poor, and if it exceeds 3%, the bitterness derived from the component (A) is amplified and cannot be suppressed, resulting in poor taste.

(C) Polyoxyethylene hydrogenated castor oil having an average number of moles of ethylene oxide added of 3 to 7 moles can be used in combination with the component (B) to produce berberine contained in the component (A) according to the component (B). It maintains the action of reaching and penetrating into the binding tissue layer without inhibiting the action of promoting penetration into the gingival bond, and also has the action of suppressing the bitterness derived from the component (A).
The average number of moles of ethylene oxide added to polyoxyethylene hydrogenated castor oil is 3 to 7 moles, and if it exceeds 7 moles, the above-mentioned action of component (B) on velverin is inhibited, and the reachability to the gingival connective tissue is poor. Those less than 3 mol are generally not commercially available.
As such polyoxyethylene hydrogenated castor oil, commercially available products such as Nippon Emulsion Co., Ltd. and Aoki Oil & Fat Industry Co., Ltd. can be used.

The blending amount of the component (C) is 0.2 to 2%, preferably 0.3 to 1.5% of the entire composition. If the blending amount is less than 0.2%, the bitterness derived from the component (A) is not suppressed and the taste is deteriorated, and if it exceeds 2%, the reachability of berberine to the gingival connective tissue is deteriorated.

In the present invention, (C) / (A) indicating the ratio of the component (A) (the amount of the component (A) blended as a powder extract) to the blended amount of the component (C) is 1 to 20 as a mass ratio. Yes, preferably 5 to 15. If the mass ratio of (C) / (A) is less than 1, the bitterness derived from the component (A) is not suppressed and the taste is poor. Poor reachability to the tissue.

Further, (B) / (C) indicating the quantitative ratio of the component (B) to the component (C) is 1.2 to 3.5, preferably 2.0 to 3.5, as a mass ratio. .. When the mass ratio of (B) / (C) is less than 1.2, the effect of promoting gingival tissue penetration of berberine is low, and the reachability to the gingival connective tissue is poor. The derived bitterness is not suppressed and the taste deteriorates.

It is preferable to further add (D) isopropylmethylphenol (3-methyl-4-isopropylphenol) to the oral composition of the present invention. When the component (D) is blended in addition to the components (B) and (C), the gingival tissue penetration promoting action of berberine contained in the component (A) is enhanced, and the reachability to the gingival connective tissue is more excellent.
As the isopropylmethylphenol, a commercially available product such as that manufactured by Osaka Kasei Co., Ltd. can be used.
The blending amount of (D) isopropylmethylphenol is preferably 0.01 to 1%, more preferably 0.05 to 0.5% of the total composition. The larger the blending amount, the higher the reachability of berberine to the gingival connective tissue, but it is preferably 1% or less in terms of ensuring solubility.

The oral composition of the present invention is particularly preferably prepared as a dentifrice composition such as dentifrice and liquid dentifrice, particularly as dentifrice. Moreover, in addition to the above-mentioned components, other known components can be blended as necessary within a range that does not interfere with the effects of the present invention. For example, in a dentifrice, an abrasive, a thickener, a binder, a surfactant, and if necessary, a sweetener, a colorant, a preservative, a fragrance, and an active ingredient can be blended. The blending amount thereof may be a normal amount as long as the effect of the present invention is not impaired, and the blending amounts shown below are all blending amounts with respect to the entire composition.

Examples of the abrasive include silica-based abrasives such as silicon dioxide, precipitated silica, aluminosilicate, and zirconosilicate, calcium phosphate-based compounds, calcium carbonate, and synthetic resin-based abrasives. The blending amount of the abrasive is usually 2 to 50%, particularly 10 to 40%.

Examples of the viscous agent include sugar alcohols such as sorbitol and xylit, and polyhydric alcohols such as glycerin and propylene glycol. The blending amount of the thickener is usually 5 to 50%, particularly 10 to 30%.

As the binder, an organic or inorganic binder can be blended. Specifically, cellulose derivatives such as sodium carboxymethyl cellulose, methyl cellulose, and hydroxymethyl cellulose, gums such as alginic acid derivatives and xanthan gum, organic binders such as carrageenan, and inorganic binders such as thickening anhydrous silicic acid and thickening aluminum silica. Can be mentioned. The blending amount of the binder is usually 0.1 to 10%, particularly 0.2 to 5%.

As an arbitrary surfactant, a surfactant other than the components (B) and (C), such as an amphoteric surfactant and a cationic surfactant, can be blended as long as the effects of the present invention are not impaired. The blending amount thereof is preferably 0 to 10%, particularly 0.001 to 5%, and any of these surfactants may not be blended.

Examples of the sweetener include sodium saccharin and the like.
Examples of the colorant include Blue No. 1, Yellow No. 4, Titanium Dioxide and the like.
Examples of the preservative include paraoxybenzoic acid ester, benzoic acid or a salt thereof.

As fragrances, peppermint oil, sparemint oil, anis oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamon oil, coriander oil, mandarin oil, Lime oil, lavender oil, rosemary oil, laurel oil, camomill oil, caraway oil, majorum oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, grapefruit oil, sweetie Natural fragrances such as oil, yuzu oil, iris concrete, absolute peppermint, absolute rose, orange flower, and processing of these natural fragrances (front reservoir cut, rear reservoir cut, distilling, liquid extraction, essence, powder Perfume (scented, etc.) and menthol, carboxylic, anator, cineole, methyl salicylate, synamic aldehyde, eugenol, 3-l-mentoxypropane-1,2-diol, timol, linalol, linalyl acetate, limonene, menton , Menthylacetate, N-substituted-paramentan-3-carboxamide, pinen, octylaldehyde, citral, pregon, calbeer acetate, anisaldehyde, ethylacetate, ethylbutyrate, allylcyclohexanepropionate, methylanthranilate, ethylmethyl Single fragrances such as phenylglycidate, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethylsulfide, cycloten, furfural, trimethylpyrazine, ethyllactate, ethylthioacetate, strawberry flavor, apple flavor, banana flavor , Peppermint flavor, Grape flavor, Mango flavor, Butter flavor, Milk flavor, Fruit mix flavor, Tropical fruit flavor and other blended fragrances, and other known fragrance materials used in oral compositions can be used in combination.
The blending amount of the fragrance is not particularly limited, but it is preferable to use 0.000001 to 1% of the above fragrance material in the composition, and the fragrance for fragrance using the above fragrance material is 0. It is preferable to use 1 to 2%.

Optional active ingredients are cationic bactericides such as cetylpyridinium chloride, anti-inflammatory agents such as tranexamic acid and allantin, enzymes such as dextranase, fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate, and water-soluble. Examples thereof include inorganic salts such as phosphate compounds, sodium chloride, potassium nitrate and aluminum lactate, vitamins such as ascorbic acid and tocopherol acetate, anti-dental agents and anti-plaque agents. These active ingredients can be blended in an effective amount within a range that does not interfere with the effects of the present invention.

Hereinafter, the present invention will be specifically described with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. In the following examples,% indicates mass% unless otherwise specified.

[Examples, comparative examples]
Toothpaste compositions (dentifrices) having the compositions shown in Tables 1 to 4 were prepared by a conventional method and evaluated by the following methods. The results are also shown in the table.

(1) Reachability of berberine to gingival connective tissue A pig mandible for meat (manufactured by Tokyo Shibaura Organ Co., Ltd.) was immersed in a solution obtained by diluting 80 g of a dentifrice composition with artificial saliva three times, and allowed to stand at 37 ° C. Placed. After 6 hours, the pig mandible was removed and washed thoroughly with purified water. The gingiva was cut out with a biopsy trepan (8 mm), and the epithelium and connective tissue were peeled off. After measuring the mass of connective tissue, it was shredded with a surgical scalpel, 0.5 mL of methanol was added, and berberine was extracted.
Berberine was quantified by high performance liquid chromatography (HPLC), and the amount of berberine per mass of connective tissue (μg / g, amount of berberine per unit tissue) was calculated.
The equipment used and the test conditions are as follows.
(Used equipment)
・ Pump: LC-20AD manufactured by Shimadzu Corporation
-Sample introduction part: SIL-20AC manufactured by Shimadzu Corporation
・ Detector: SPD-20A manufactured by Shimadzu Corporation
・ Column constant temperature bath: CTO-20AC manufactured by Shimadzu Corporation
・ Eluent flow rate: 1 mL / min
(Test conditions)
-Detector: Ultraviolet absorptiometer (measurement wavelength: 273 nm)
-Column: COSMOSIL 5C _18- MS-II
-Column temperature: 40 ° C
-Mobile phase: 5 g of sodium lauryl sulfate and 3 g of L-tartaric acid were dissolved in 400 mL of water, and 400 mL of acetonitrile and 200 mL of methanol were added.

From the amount of berberine per mass of the obtained connective tissue (μg / g), the reachability of berberine to the gingival connective tissue (the reach of berberine to the gingival connective tissue layer, the degree of penetration) was determined by the following scoring criteria. Berberine reached and penetrated the gingival connective tissue of two or more points, and it was judged that the reachability to the gingival connective tissue was acceptable.
Rating criteria 4 points: Berberine amount is 0.3 μg / g or more 3 points: Berberine amount is 0.2 μg / g or more and less than 0.3 μg / g 2 points: Berberine peak is detected and berberine amount is 0.2 μg / g
Less than 1 point: Berberine peak not detected

(2) Usability (no bitterness)
Nine subject monitors extruded 1 g of the dentifrice composition filled in a general laminated tube container, placed it on a toothbrush, and judged the taste (bitter taste) when the oral cavity was brushed for 3 minutes according to the following scoring criteria. .. The average of the evaluation points of 9 people was calculated, and the usability (no bitterness) was evaluated according to the following evaluation criteria. Those with 〇 or ◎ were judged to have a good taste with suppressed bitterness and a good usability.
Rating criteria 4 points: No bitterness in the oral cavity 3 points: Almost no bitterness in the oral cavity 2 points: Slight bitterness in the oral cavity but acceptable level 1 point: Very bitter taste in the oral cavity Evaluation criteria ◎: Average score is 3.0 points or more and 4.0 points or less 〇: Average score is 2.0 points or more and less than 3.0 points ×: Average score is less than 2.0 points

Details of the raw materials used are shown below.
(A) Phellodendron extract:
Made by Koshiro Pharmaceutical Co., Ltd., trade name; Phellodendron amur extract (dry powder extract)
In this experiment, Oubaquex containing 5% berberine in the powder extract was used.
(B) Sodium lauryl sulfate:
Made by BASF Japan Ltd., trade name; Texas OC-P
Lauroylmethyl taurine sodium (comparative product):
Made by Nikko Chemicals Co., Ltd., trade name; NIKKOL LMT
(C) Polyoxyethylene (5) Hardened castor oil:
Made by Nippon Emulsion Co., Ltd., Product name: EMALEX HC-5
Average number of moles of ethylene oxide added 5
(C) Polyoxyethylene (3) Hardened castor oil;
Made by Aoki Oil & Fat Industry Co., Ltd., Product name: CW-3
Average number of moles of ethylene oxide added 3
(C) Polyoxyethylene (7) Hardened castor oil:
Made by Nippon Emulsion Co., Ltd., Product name: EMALEX HC-7
Average number of moles of ethylene oxide added 7
Polyoxyethylene (10) hardened castor oil (comparative product):
Made by Nippon Emulsion Co., Ltd., Product name: EMALEX HC-10
Average number of moles of ethylene oxide added 10
Polyoxyethylene (20) hardened castor oil (comparative product):
Made by Nippon Emulsion Co., Ltd., Product name: EMALEX HC-20
Average number of moles of ethylene oxide added 20
(D) Isopropylmethylphenol:
Made by Osaka Kasei Co., Ltd., Product name: Isopropylmethylphenol

Claims

(A) 0.02 to 0.5% by mass of Phellodendron amur extract as a powder extract,
(B) 0.5 to 3% by mass of sodium alkyl sulfate
And (C) 0.2 to 2% by mass of polyoxyethylene hydrogenated castor oil having an average number of moles of ethylene oxide added of 3 to 7 mol.
An oral composition containing 1 to 20 by mass ratio of (C) / (A) and 1.2 to 3.5 by mass ratio of (B) / (C).
(A) The oral composition according to claim 1, wherein the Phellodendron amur extract has a berberine content of 3% by mass or more in the powder extract.
The oral composition according to claim 1 or 2, further containing 0.01 to 1% by mass of (D) isopropylmethylphenol.
The oral composition according to any one of claims 1 to 3, which is a dentifrice composition.