WO2021169063A1 - 一种直接种植的个性化牙槽骨修复假体及其制备方法 - Google Patents

一种直接种植的个性化牙槽骨修复假体及其制备方法 Download PDF

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WO2021169063A1
WO2021169063A1 PCT/CN2020/091754 CN2020091754W WO2021169063A1 WO 2021169063 A1 WO2021169063 A1 WO 2021169063A1 CN 2020091754 W CN2020091754 W CN 2020091754W WO 2021169063 A1 WO2021169063 A1 WO 2021169063A1
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alveolar bone
personalized
prosthesis
filling body
implant
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PCT/CN2020/091754
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English (en)
French (fr)
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张春雨
季方秋
陈贤帅
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广州市健齿生物科技有限公司
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Publication of WO2021169063A1 publication Critical patent/WO2021169063A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0018—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the shape
    • A61C8/0037—Details of the shape
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C13/00—Dental prostheses; Making same
    • A61C13/0003—Making bridge-work, inlays, implants or the like
    • A61C13/0004—Computer-assisted sizing or machining of dental prostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C13/00—Dental prostheses; Making same
    • A61C13/0003—Making bridge-work, inlays, implants or the like
    • A61C13/0006—Production methods
    • A61C13/0019—Production methods using three dimensional printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0093—Features of implants not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material

Definitions

  • the invention relates to the technical field of dental implants, in particular to a directly implanted personalized alveolar bone restoration prosthesis, and a method for preparing the alveolar bone restoration prosthesis.
  • Dental implant surgery is currently the best way to repair missing dentition.
  • the principle is to drill an implant hole in the alveolar bone in advance, and then screw the implant into the implant hole to make the bone union with the alveolar bone. If the patient's alveolar bone is missing due to tumor or mechanical damage, the patient needs to be repaired by bone grafting or bone powder filling, and then a second dental implant surgery is performed for the patient who needs dental implantation.
  • a prosthesis for repair.
  • the prosthesis generally simulates the shape of the patient's natural bones and plays the role of retaining the bones while supporting the shape.
  • the technical solution aims to provide a directly implanted personalized alveolar bone restoration prosthesis to solve one or more technical problems existing in the prior art, and at least provide a beneficial choice or create conditions.
  • a directly implanted personalized alveolar bone restoration prosthesis comprising a filling body, a left wing part and a right wing part, the left wing part is provided with a retention plate extending to the left, and the right wing part is provided with a right wing extending A retention plate, the filling body is a metal porous body formed by 3D printing, the upper end of the filling body is provided with an implant mounting end surface, and at least one implant abutment is provided on the mounting end surface.
  • the pore diameter of the porous metal body is 600 um, and the gap between the pores is 1.2 mm.
  • the length of the retention plate is greater than or equal to 10 mm, and at least two through holes are provided on the retention plate.
  • the thickness of the retention plate is greater than or equal to 0.3 mm.
  • the filling body is provided with a cavity, and the bottom of the filling body is provided with an opening, and the opening is in communication with the cavity.
  • the planting abutment is in the shape of a truncated cone, a hexagonal groove is arranged in the middle of the top surface, and a screw hole is arranged in the hexagonal groove.
  • this technical solution also provides a method for preparing a directly implanted personalized alveolar bone restoration prosthesis, which includes the steps:
  • step 5 Combine the retaining plate of step 4 and the three-dimensional model of the filling body of step 3 into one to obtain a personalized alveolar bone restoration model;
  • the metal particles are pure titanium particles.
  • the present invention ensures the initial stability of the restoration prosthesis by combining the implant abutment and the filling body, and at the same time, replaces the combination of the dental implant and the bone by the mechanical combination and fixation of the filling body and the implant abutment. Thereby ensuring the stability of the dental implant effect.
  • the filling body adopts a porous structure design, which can fill the patient's autologous bone and osteoinductive factors inside the prosthesis, induce bones to grow into the porous, so as to achieve better biocompatibility and binding stability.
  • the invention significantly reduces the number of operations and the difficulty of operations, at the same time shortens the recovery time of patients, and improves the success rate of dental implantation.
  • Fig. 1 is a front view of the directly implanted personalized alveolar bone prosthesis in embodiment 1;
  • Figure 2 is a right view of the directly implanted personalized alveolar bone prosthesis described in Example 1;
  • FIG. 3 is a top view of the personalized alveolar bone restoration prosthesis directly implanted in Example 1.
  • Example 1 the directly implanted personalized alveolar bone restoration prosthesis was prepared according to the following steps:
  • step 3 import the alveolar bone model of step 2 into Magics software, and obtain a three-dimensional model of the filling body suitable for the defect of the alveolar bone through the Boolean operation function.
  • the patient's autologous bone fragments and bone-inducing factors are filled into the cavity of the personalized alveolar bone repair model prosthesis, and then the patient's alveolar bone defect can be implanted.
  • the prepared personalized alveolar bone repair model prosthesis is shown in Figures 1 to 3, including a filling body 001, a left wing part and a right wing part.
  • the left wing part is provided with a retention plate 002 extending to the left, and the right wing part
  • the part is provided with a retention plate 002 extending to the right.
  • the filling body 001 is a metal porous body made by 3D printing.
  • the upper end of the filling body 001 is provided with an implant mounting end surface, and at least one Implant abutment 003.
  • the pore diameter of the porous metal body is 600 um, and the gap between the pores is 1.2 mm.
  • the length of the retention plate 002 is greater than or equal to 10 mm, the retention plate 002 is provided with at least two through holes 004, and the thickness of the retention plate 002 is greater than or equal to 0.3 mm.
  • the filling body 001 is provided with a cavity, and the bottom of the filling body 001 is provided with an opening, and the opening is in communication with the cavity.
  • the planting base 003 is in the shape of a truncated cone, a hexagonal groove is arranged in the middle of the top surface, and a screw hole is arranged in the hexagonal groove.

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dentistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Prostheses (AREA)

Abstract

一种直接种植的个性化牙槽骨修复假体，包括填充体（001）、左翼部和右翼部，左翼部设有向左侧延伸的固位板（002），右翼部设有向右侧延伸的固位板（002），填充体（001）为3D打印而成的金属多孔体，填充体（001）上端设有种植体安装端面，安装端面上设有至少一个种植体基台（003）。通过将种植体基台（003）与填充体（001）结合在一起的方式保证了修复假体的初期稳定性，同时通过填充体（001）与种植体基台（003）的机械结合固定的方式取代了牙种植体与骨骼结合，从而保证了牙种植效果的稳定。

Description

一种直接种植的个性化牙槽骨修复假体及其制备方法 技术领域
本发明涉及牙种植体技术领域，特别涉及一种直接种植的个性化牙槽骨修复假体，以及制备该牙槽骨修复假体的方法。
背景技术
牙种植手术是目前牙列缺失进行修复的最佳修复方式，其原理是通过事先在牙槽骨上钻取种植孔，然后将种植体旋入种植孔使其与牙槽骨进行骨结合。因肿瘤或者机械损伤等原因造成患者牙槽骨缺失的情况需要对患者进行植骨或者填充骨粉等方式进行修复，然后对于需要牙种植的患者进行二次牙种植手术。对于牙槽骨缺损较大的患者，自体骨无法完全进行修复的时候需要使用修复假体进行修复。修复假体一般模拟患者自然骨骼的外形，起到固位骨骼同时支撑外形的作用。
传统牙种植技术需要事先进行骨移植或者骨粉填充手术，操作复杂，成本较高。尤其对于较大范围的牙槽骨缺损病例需要大块的自体骨进行修复，损伤较大。同时患者需要大量时间来进行恢复，继续进行牙种植手术同样需要大量时间进行恢复。整个种植手术的难度较大且需要多次手术，过程繁琐。同时又需要考虑牙种植体的初期稳定性与骨结合性能，因此骨缺损较大患者的牙种植成功率不高。
发明内容
本技术方案旨在提供一种直接种植的个性化牙槽骨修复假体，以 解决现有技术中所存在的一个或多个技术问题，至少提供一种有益的选择或创造条件。
一种直接种植的个性化牙槽骨修复假体，包括填充体、左翼部和右翼部，所述左翼部设有向左侧延伸的固位板，所述右翼部设有向右侧延伸的固位板，所述填充体为3D打印而成的金属多孔体，所述填充体上端设有种植体安装端面，所述安装端面上设有至少一个种植体基台。
进一步，所述金属多孔体的孔径为600um，孔的间隙为1.2mm。
进一步，所述固位板长度大于等于10mm，所述固位板上设置有至少两个贯穿孔。优选地，所述固位板的厚度大于等于0.3mm。
进一步，所述填充体内设有空腔，所述填充体底部设有开口，所述开口与所述空腔连通。
进一步，所述种植基台呈圆台状，顶面中部设有六边形凹槽，所述六边形凹槽内设有螺孔。
另一方面，本技术方案还提供了制备直接种植的个性化牙槽骨修复假体的方法，其包括步骤：
1)获取牙槽骨缺损处及周边骨骼的形态数据，将形态数据导入软件，生成与牙槽骨缺损处相适配的填充体三维模型；
2)确定填充体三维模型的种植体安装端面，以及种植体安装端面上的种植体基台的位置与数目；
3)对填充体三维模型进行结构化多孔设计；
4)生成与牙槽骨缺损处周边骨骼轮廓贴合的固位板，并在固位 板上设置贯穿孔；
5)将步骤4的固位板与步骤3的填充体三维模型并为一体，得到个性化牙槽骨修复模型；
6)将个性化牙槽骨修复模型导入SLM打印机中进行打印制造得到个性化牙槽骨修复模型假体，通过喷砂与抛光处理去除粘附在个性化牙槽骨修复模型假体上的未熔的金属颗粒。
具体地，所述金属颗粒为纯钛颗粒。
本发明通过将种植体基台与填充体结合在一起的方式保证了修复假体的初期稳定性，同时通过填充体与种植体基台的机械结合固定的方式取代了牙种植体与骨骼结合，从而保证了牙种植效果的稳定。填充体采用多孔结构设计，可在假体内部填充患者自体骨与骨诱导因子，诱导骨骼长入多孔中，从而达到较好的生物相容性与结合稳定性。本发明显著减少了手术的次数以及降低了手术的难度，同时缩短了患者的恢复时间，提高了牙种植的成功率。
附图说明
为了更清楚地说明本发明实施例中的技术方案，下面将对实施例描述中所需要使用的附图作简单说明。显然，所描述的附图只是本发明的一部分实施例，而不是全部实施例，本领域的技术人员在不付出创造性劳动的前提下，还可以根据这些附图获得其他设计方案和附图。
图1是实施例1所述直接种植的个性化牙槽骨修复假体的主视图；
图2是实施例1所述直接种植的个性化牙槽骨修复假体的右视图；
图3是实施例1所述直接种植的个性化牙槽骨修复假体的俯视图。
具体实施方式
下面详细描述本发明的实施例，所述实施例的示例在附图中示出，其中自始至终相同或类似的标号表示相同或类似的元件或具有相同或类似功能的元件。下面通过参考附图描述的实施例是示例性的，仅用于解释本发明，而不能理解为对本发明的限制。
在本发明的描述中，若干的含义是一个或者多个，多个的含义是两个以上，大于、小于、超过等理解为不包括本数，以上、以下、以内等理解为包括本数。如果有描述到第一、第二只是用于区分技术特征为目的，而不能理解为指示或暗示相对重要性或者隐含指明所指示的技术特征的数量或者隐含指明所指示的技术特征的先后关系。
本发明的描述中，除非另有明确的限定，设置、安装、连接等词语应做广义理解，所属技术领域技术人员可以结合技术方案的具体内容合理确定上述词语在本发明中的具体含义。
实施例1，根据以下步骤制备直接种植的个性化牙槽骨修复假体：
1、通过CT扫描患者牙槽骨缺损处及周边骨骼获取所需形态数据，再将数据导入MIMICS软件中生成STL格式的牙槽骨模型，再进行修复。
2、将患者带有缺损部分的牙槽骨模型导入Magics软件中，通过 拉伸功能修复好缺损。
3、再将步骤2的牙槽骨模型导入Magics软件中，通过布尔运算功能得到与牙槽骨缺损处相适配的填充体三维模型。
4、确定填充体三维模型的种植体安装端面，以及种植体安装端面上的种植体基台的位置与数目，然后通过布尔运算功能去除填充体三维模型内部的填充，最后得到薄壁结构的填充体三维模型。
5、对填充体三维模型进行修复然后进行结构化多孔设计。
6、在PRO/E软件中绘制出种植体基台的模型，将其以STL的格式保存导入到Magics软件中。
7、通过Magics软件的移动与约束功能将种植体基台与填充体三维模型组装在一起，然后通过布尔运算功能将两者并为一体。
8、利用Magics软件中的拉伸与切割功能在第2步得到牙槽骨模型上得到固位板模型并打孔。
9、通过Magics软件中布尔运算功能将固位板模型与步骤7所得的填充体三维模型并为一体，进行修复后得到直接种植的个性化牙槽骨修复模型。
10、将个性化牙槽骨修复模型导入SLM打印机中进行打印制造得到个性化牙槽骨修复模型假体，通过喷砂与抛光处理去除粘附在个性化牙槽骨修复模型假体上的未熔的金属颗粒。
11、进行灭菌处理后，在个性化牙槽骨修复模型假体空腔中填充患者的自体骨碎片与诱骨因子，然后可以植入患者牙槽骨缺损处。
制得的个性化牙槽骨修复模型假体如图1～3所示，包括填充体 001、左翼部和右翼部，所述左翼部设有向左侧延伸的固位板002，所述右翼部设有向右侧延伸的固位板002，所述填充体001为3D打印而成的金属多孔体，所述填充体001上端设有种植体安装端面，所述安装端面上设有至少一个种植体基台003。所述金属多孔体的孔径为600um，孔的间隙为1.2mm。所述固位板002长度大于等于10mm，所述固位板002上设置有至少两个贯穿孔004，所述固位板002的厚度大于等于0.3mm。所述填充体001内设有空腔，所述填充体001底部设有开口，所述开口与所述空腔连通。所述种植基台003呈圆台状，顶面中部设有六边形凹槽，所述六边形凹槽内设有螺孔。
在本说明书的描述中，参考术语“一个实施例”、“一些实施例”、“示意性实施例”、“示例”、“具体示例”、或“一些示例”等的描述意指结合该实施例或示例描述的具体特征、结构、材料或者特点包含于本发明的至少一个实施例或示例中。在本说明书中，对上述术语的示意性表述不一定指的是相同的实施例或示例。而且，描述的具体特征、结构、材料或者特点可以在任何的一个或多个实施例或示例中以合适的方式结合。
尽管已经示出和描述了本发明的实施例，本领域的普通技术人员可以理解：在不脱离本发明的原理和宗旨的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由权利要求及其等同物限定。

Claims (8)

  1. 一种直接种植的个性化牙槽骨修复假体，其特征在于：包括填充体、左翼部和右翼部，所述左翼部设有向左侧延伸的固位板，所述右翼部设有向右侧延伸的固位板，所述填充体为3D打印而成的金属多孔体，所述填充体上端设有种植体安装端面，所述安装端面上设有至少一个种植体基台。
  2. 根据权利要求1所述的直接种植的个性化牙槽骨修复假体，其特征在于：所述金属多孔体的孔径为600um，孔的间隙为1.2mm。
  3. 根据权利要求1所述的直接种植的个性化牙槽骨修复假体，其特征在于：所述固位板长度大于等于10mm，所述固位板上设置有至少两个贯穿孔。
  4. 根据权利要求3所述的直接种植的个性化牙槽骨修复假体，其特征在于：所述固位板的厚度大于等于0.3mm。
  5. 根据权利要求1所述的直接种植的个性化牙槽骨修复假体，其特征在于：所述填充体内设有空腔，所述填充体底部设有开口，所述开口与所述空腔连通。
  6. 根据权利要求1所述的直接种植的个性化牙槽骨修复假体，其特征在于：所述种植基台呈圆台状，顶面中部设有六边形凹槽，所述六边形凹槽内设有螺孔。
  7. 一种直接种植的个性化牙槽骨修复假体的制备方法，其特征在于，包括步骤：
    1)获取牙槽骨缺损处及周边骨骼的形态数据，将形态数据导入软 件，生成与牙槽骨缺损处相适配的填充体三维模型；
    2)确定填充体三维模型的种植体安装端面，以及种植体安装端面上的种植体基台的位置与数目；
    3)对填充体三维模型进行结构化多孔设计；
    4)生成与牙槽骨缺损处周边骨骼轮廓贴合的固位板，并在固位板上设置贯穿孔；
    5)将步骤4的固位板与步骤3的填充体三维模型并为一体，得到个性化牙槽骨修复模型；
    6)将个性化牙槽骨修复模型导入SLM打印机中进行打印制造得到个性化牙槽骨修复模型假体，通过喷砂与抛光处理去除粘附在个性化牙槽骨修复模型假体上的未熔的金属颗粒。
  8. 根据权利要求7所述的直接种植的个性化牙槽骨修复假体的制备方法，其特征在于，所述金属颗粒为纯钛颗粒。
PCT/CN2020/091754 2020-02-28 2020-05-22 一种直接种植的个性化牙槽骨修复假体及其制备方法 WO2021169063A1 (zh)

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