WO2021160030A1 - 一种体内肺膜氧合多功能球囊扩张导管及使用方法 - Google Patents
一种体内肺膜氧合多功能球囊扩张导管及使用方法 Download PDFInfo
- Publication number
- WO2021160030A1 WO2021160030A1 PCT/CN2021/075458 CN2021075458W WO2021160030A1 WO 2021160030 A1 WO2021160030 A1 WO 2021160030A1 CN 2021075458 W CN2021075458 W CN 2021075458W WO 2021160030 A1 WO2021160030 A1 WO 2021160030A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- catheter
- channel
- balloon
- expansion
- lung
- Prior art date
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 28
- 238000006213 oxygenation reaction Methods 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims description 20
- 210000004072 lung Anatomy 0.000 claims abstract description 51
- 230000028327 secretion Effects 0.000 claims abstract description 37
- 238000001514 detection method Methods 0.000 claims abstract description 35
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000001301 oxygen Substances 0.000 claims abstract description 34
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 34
- 238000011282 treatment Methods 0.000 claims abstract description 26
- 239000003814 drug Substances 0.000 claims abstract description 16
- 206010036790 Productive cough Diseases 0.000 claims abstract description 15
- 208000024794 sputum Diseases 0.000 claims abstract description 15
- 210000003802 sputum Anatomy 0.000 claims abstract description 15
- 238000003780 insertion Methods 0.000 claims abstract description 11
- 230000037431 insertion Effects 0.000 claims abstract description 11
- 210000003123 bronchiole Anatomy 0.000 claims abstract description 10
- 238000001574 biopsy Methods 0.000 claims abstract description 8
- 210000000621 bronchi Anatomy 0.000 claims description 18
- 208000031481 Pathologic Constriction Diseases 0.000 claims description 12
- 238000001727 in vivo Methods 0.000 claims description 12
- 208000037804 stenosis Diseases 0.000 claims description 12
- 238000011010 flushing procedure Methods 0.000 claims description 11
- 230000036262 stenosis Effects 0.000 claims description 11
- 230000008569 process Effects 0.000 claims description 8
- 238000002627 tracheal intubation Methods 0.000 claims description 7
- 239000013307 optical fiber Substances 0.000 claims description 5
- 230000010412 perfusion Effects 0.000 claims description 5
- 230000010339 dilation Effects 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 238000002955 isolation Methods 0.000 claims description 3
- 239000002861 polymer material Substances 0.000 claims description 2
- 206010035664 Pneumonia Diseases 0.000 abstract description 12
- 230000006378 damage Effects 0.000 abstract description 10
- 230000002685 pulmonary effect Effects 0.000 abstract description 5
- 208000025721 COVID-19 Diseases 0.000 abstract description 2
- 230000000916 dilatatory effect Effects 0.000 abstract 1
- 230000004083 survival effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 210000004379 membrane Anatomy 0.000 description 16
- 230000006870 function Effects 0.000 description 12
- 230000002757 inflammatory effect Effects 0.000 description 10
- 239000008280 blood Substances 0.000 description 9
- 210000004369 blood Anatomy 0.000 description 9
- 229940079593 drug Drugs 0.000 description 9
- 210000002345 respiratory system Anatomy 0.000 description 9
- 238000010586 diagram Methods 0.000 description 8
- 238000002618 extracorporeal membrane oxygenation Methods 0.000 description 8
- 239000007921 spray Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 241000711573 Coronaviridae Species 0.000 description 4
- 206010021143 Hypoxia Diseases 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000002560 therapeutic procedure Methods 0.000 description 4
- 102100035765 Angiotensin-converting enzyme 2 Human genes 0.000 description 3
- 108090000975 Angiotensin-converting enzyme 2 Proteins 0.000 description 3
- 208000028399 Critical Illness Diseases 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 3
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 3
- 206010038687 Respiratory distress Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000007954 hypoxia Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 229920000642 polymer Polymers 0.000 description 3
- 201000004193 respiratory failure Diseases 0.000 description 3
- 238000012800 visualization Methods 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 208000001572 Mycoplasma Pneumonia Diseases 0.000 description 2
- 201000008235 Mycoplasma pneumoniae pneumonia Diseases 0.000 description 2
- 201000010001 Silicosis Diseases 0.000 description 2
- 230000008382 alveolar damage Effects 0.000 description 2
- 238000000889 atomisation Methods 0.000 description 2
- 238000013276 bronchoscopy Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 238000012377 drug delivery Methods 0.000 description 2
- 210000003191 femoral vein Anatomy 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- 230000002980 postoperative effect Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 210000003437 trachea Anatomy 0.000 description 2
- 201000008827 tuberculosis Diseases 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 206010001881 Alveolar proteinosis Diseases 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- 206010018691 Granuloma Diseases 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920002614 Polyether block amide Polymers 0.000 description 1
- 239000004721 Polyphenylene oxide Substances 0.000 description 1
- 206010039580 Scar Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003872 anastomosis Effects 0.000 description 1
- 239000010425 asbestos Substances 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 238000011888 autopsy Methods 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 201000009267 bronchiectasis Diseases 0.000 description 1
- 230000007883 bronchodilation Effects 0.000 description 1
- 230000003139 buffering effect Effects 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000002612 cardiopulmonary effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000002639 hyperbaric oxygen therapy Methods 0.000 description 1
- 230000001146 hypoxic effect Effects 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 210000004731 jugular vein Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000011418 maintenance treatment Methods 0.000 description 1
- 238000005399 mechanical ventilation Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000002640 oxygen therapy Methods 0.000 description 1
- 238000010827 pathological analysis Methods 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- -1 polyethylene terephthalate Polymers 0.000 description 1
- 208000005069 pulmonary fibrosis Diseases 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000004202 respiratory function Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 229910052895 riebeckite Inorganic materials 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000003319 supportive effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0402—Special features for tracheal tubes not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0463—Tracheal tubes combined with suction tubes, catheters or the like; Outside connections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0486—Multi-lumen tracheal tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
- A61M29/02—Dilators made of swellable material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0434—Cuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0475—Tracheal tubes having openings in the tube
- A61M16/0477—Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0475—Tracheal tubes having openings in the tube
- A61M16/0477—Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids
- A61M16/0484—Tracheal tubes having openings in the tube with incorporated means for delivering or removing fluids at the distal end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/04—Tracheal tubes
- A61M16/0488—Mouthpieces; Means for guiding, securing or introducing the tubes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0036—Multi-lumen catheters with stationary elements with more than four lumina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M2025/0037—Multi-lumen catheters with stationary elements characterized by lumina being arranged side-by-side
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0208—Oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/10—Trunk
- A61M2210/1025—Respiratory system
- A61M2210/1035—Bronchi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/0021—Catheters; Hollow probes characterised by the form of the tubing
- A61M25/0023—Catheters; Hollow probes characterised by the form of the tubing by the form of the lumen, e.g. cross-section, variable diameter
- A61M25/0026—Multi-lumen catheters with stationary elements
- A61M25/0032—Multi-lumen catheters with stationary elements characterized by at least one unconventionally shaped lumen, e.g. polygons, ellipsoids, wedges or shapes comprising concave and convex parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
- A61M25/06—Body-piercing guide needles or the like
- A61M25/0662—Guide tubes
Definitions
- the invention relates to the field of membrane lung oxygenation, in particular to a multifunctional balloon expansion catheter and method for lung membrane oxygenation in vivo.
- the novel coronavirus pneumonia epidemic is the COVID-19 (novel Coronavirus Disease 2019) coronavirus.
- COVID-19 novel Coronavirus Disease 2019
- ACE2 receptors are widely present on various mucosal cells of the human body.
- the virus invades the human body, it incubates for 2-3 weeks, and then rapidly multiplies and stimulates the patient's autoimmune mechanism to develop the disease.
- the initial symptoms are similar to the common cold. If it cannot be effectively controlled, about 20% of patients become severely ill in about 1 week.
- CT films showed limited (early) or diffuse (late) hairy shadows (white lungs) of the lungs on both sides.
- Pathology showed that the patient’s lungs began to have an inflammatory response from the end, a large amount of viscous inflammatory secretions covering the bronchioles and alveoli (formed the white lungs seen in the CT film) blocking the normal gas exchange of the lung membranes, resulting in blood oxygen saturation The rapid decline. Hypoxia further exacerbates the damage of other organs, especially in the elderly or patients who suffer from other diseases at the same time.
- the current treatment methods for the new coronavirus are currently not perfect, and various supportive treatments are the main clinical treatment.
- the only rescue measures for critically ill patients are mechanical oxygen supply and artificial lung (ECMO), and the success rate is very low.
- ECMO mechanical oxygen supply and artificial lung
- the latest pathological analysis results show that a large number of viscous secretions accumulated in the lungs of critically ill patients block the respiratory tract, hinder the lung ventilation function, and even make the mechanical oxygen unable to reach the end of the bronchus and hypoxia, and the long-term hypoxia of the peripheral and alveoli makes the alveolar damage and leads to the ventilation function. obstacle.
- a common treatment method is maintenance treatment with tracheal intubation and ventilator.
- assisted breathing becomes a necessary measure.
- mucin secreted by the epidermal cells of the respiratory tract in the late stage of the new crown the viscous secretions block the airway, so that the input oxygen cannot effectively reach the alveoli for gas exchange, causing alveolar damage.
- high-flow, hyperbaric oxygen therapy may push the clogged viscous secretions in the patient's airway to the lower respiratory tract to form a sputum plug, which further blocks the microbronchi and can cause bacterial infection. Therefore, before oxygen therapy, it is necessary to dilute, dissolve and eliminate the viscous secretions in the patient's airway.
- ECMO extracorporeal membrane oxygenation
- ECMO extracorporeal membrane oxygenation
- the ventilator cannot maintain the patient's blood oxygen level
- the patient needs to be transferred to the ICU for extracorporeal membrane oxygenation (ECMO).
- ECMO is the last treatment when the patient is unable to effectively receive mechanical ventilation due to various reasons.
- the patient’s femoral vein puncture will lead the blood out and the blood will be drawn through the femoral vein puncture, and the ECMO machine will be used to artificially oxygenate the hypoxic blood.
- the oxygen-rich blood will then be artificially oxygenated by the neck machine to enrich the oxygen.
- the blood is returned to the patient's heart through the jugular vein.
- ECMO replaces the cardiopulmonary function of new coronary patients with respiratory failure and heart failure to perform blood purification and oxygenation, so that the patient's heart and lungs can rest and fight for time for self-healing.
- Long-term use of ECMO can cause serious side effects to patients, such as abnormal blood coagulation, kidney function damage, circulatory function damage (decreased tissue perfusion capacity) and respiratory function damage (lung perfusion).
- the cost of using ECMO is also very expensive, because it must be used in the ICU, and the daily cost of ICU use is also very considerable (about 100,000 yuan). The price of this equipment is high, and small town hospitals are hardly equipped.
- the most commonly used respiratory tract interventional therapy is the treatment of bronchial stenosis by bronchoscope balloon dilatation.
- a special three-stage dilatation balloon catheter is inserted into a narrow airway through a bronchoscope to perform step-by-step expansion.
- a number of clinical data have proved that the postoperative expansion rate of balloon dilatation for benign airway stenosis is 90%-100%, and the re-stenosis rate after 6 months is less than 20%.
- Bronchoalveolar lavage is a new technology developed on the basis of fiberoptic bronchoscopy. It is to infuse physiological saline into the lungs through a bronchoscope and then suck it out with negative pressure to collect the surface fluid of the alveoli for various lung diseases, such as alveoli
- a method for differential diagnosis of inflammation, pulmonary fibrosis, asbestos lung, lung cancer, pneumocysticercosis, and alveolar proteinosis In recent years, it has gradually been used to treat patients with severe respiratory failure. The clinical manifestations of postoperative patients have improved. Saturation and oxygen partial pressure increased significantly, while carbon dioxide partial pressure decreased significantly.
- Interventional therapy has not been reported in the current treatment of patients with new coronary pneumonia. This is because any single device used for pulmonary interventional therapy internationally has limited functions and cannot meet the complex and rapidly evolving course of the treatment of patients with severe new coronary pneumonia.
- the latest autopsy results show that the main reason for the current poor treatment effect is that a large number of viscous inflammatory secretions in the lung tissue accumulate in the bronchus and the surface of the lung membrane at the bottom of the lung, hindering the normal oxygenation of the lung membrane. Therefore, quickly and effectively clearing the "silt" on the bronchi and lung membranes is the key to first aid for new coronary pneumonia.
- bronchoscopy and conventional sputum aspiration techniques can be used to cleanse sputum, they are limited to high air ducts and have a single function. They are basically ineffective for pulmonary inflammatory storms in patients with new coronary disease. Therefore, clinically there is an urgent need for a set of "bronchodilation, sputum discharge” , Alveolar lavage, continuous oxygen supply, atomization and drug delivery” a multi-functional device for the first aid of patients with new coronary disease.
- the purpose of the present invention is to provide a multifunctional balloon dilatation catheter for lung membrane oxygenation in vivo and a method of use.
- a multifunctional balloon dilatation catheter for lung membrane oxygenation in vivo comprising a catheter base at the proximal end of the catheter, an expansion balloon at the distal end of the catheter, and M in the catheter
- the M channels include at least a balloon expansion channel, a positioning detection channel, a supply channel, and a secretion removal channel;
- M is an integer greater than or equal to 4;
- the catheter adapter is a multi-channel connection device, and the M channels are respectively The treatment device connected to the outside of the catheter through the catheter base;
- the catheter is inserted into the pulmonary bronchioles, the balloon expansion channel is used to expand the narrowed part of the airway, the positioning detection channel is used to locate or detect during the insertion process; the supply channel is used to perform treatment on the patient With continuous oxygen or administration, the secretion removal channel is used to remove secretions in the airway.
- the balloon expansion channel is connected to the balloon inflation device through the catheter socket;
- the expansion balloon includes an expansion port;
- the secretion drainage channel is connected to a sputum suction machine or a pressure syringe through a catheter base, and the secretion drainage channel includes a flushing air port;
- the supply channel is connected to the supply device through the catheter socket, and the supply channel includes a supply air port;
- the positioning detection channel runs through both ends of the catheter and can be passed through by a guide wire, a biopsy forceps or an optical fiber endoscope.
- cross-sectional area of the secretion removal channel is larger than the cross-sectional area of the balloon expansion channel and the supply channel.
- the positioning detection channel is a cylindrical channel; the inner diameter of the positioning detection channel is greater than 0.1 mm and less than or equal to 5.0 mm
- the expansion balloon is a three-stage expansion balloon
- the expansion pressure of the three-stage expansion balloon is 3-18 atm
- the outer diameter of the third-stage expansion balloon is 3 mm-24 mm under inflated conditions.
- the expansion balloon is a single-stage expansion balloon
- the expansion pressure range of the single-stage expansion balloon is 3-30 atm
- the outer diameter of the single-stage expansion balloon is 3 mm-30 mm under inflated conditions.
- the catheter is a polymer material catheter, and the material of the isolation between the M channels in the catheter is the same as that of the catheter.
- the catheter socket is connected to a Luer connector, and the Luer connector and the catheter socket connect the M channels with external corresponding treatment devices.
- a method for using the above catheter to perform intracorporeal membrane lung oxygenation includes the following steps:
- the catheter is inserted into the lung bronchus through a tracheal intubation or through a tracheal endoscope.
- the positioning detection channel is used to guide the forward direction of the catheter, and the balloon expansion channel controls the balloon to expand the stenosis;
- the secretion removal channel is used to perform perfusion and flushing and sputum suction to the designated position.
- the present invention organically combines the expansion balloon and the multi-lumen catheter technology, and has a small outer diameter, which can be directly inserted into the lung bronchus under the guidance of a bronchoscope or an optical fiber endoscope;
- the expansion of the expansion balloon is used to open up the obstructed airway;
- the secretion removal channel through the secretion removal channel, the inflammatory discharge on the surface of the lung membrane can be sucked and flushed, and the oxygenation function of the lung membrane itself can be restored.
- This product can also be used to treat pneumonia caused by various reasons (such as mycoplasma pneumonia, respiratory tract stenosis caused by tuberculosis, pneumonia), silicosis, etc.
- Figure 1 is a schematic diagram of the structure of the catheter of the present invention.
- Figure 2 is a schematic diagram of each channel in the catheter of the present invention.
- Figure 3 is a schematic diagram of the balloon part in the catheter of the present invention.
- Fig. 4 is a schematic diagram of the position of the balloon when the catheter is inserted into the lower respiratory tract of the lung according to the present invention
- FIG. 5 is a physical diagram of the catheter socket in the present invention.
- Fig. 6 is a physical diagram of the catheter of the present invention.
- a multifunctional balloon dilatation catheter for lung membrane oxygenation in vivo comprising a catheter base 5 located at the proximal end of the catheter, an expansion balloon 6 located at the distal end of the catheter, and M channels located in the catheter.
- the catheter base is a multi-channel connection device, and the M channels are respectively connected to the treatment device outside the catheter through the catheter base.
- the catheter socket can also be connected with a Luer connector. The Luer connector and the catheter socket connect the M channels with the external corresponding treatment devices, and enable switching between the external corresponding treatment devices.
- the M channels include at least the balloon expansion channel 3, the positioning detection channel 4, the supply channel 2 and the secretion removal channel; M is an integer greater than or equal to 4.
- FIG. 6 it is a physical diagram of the catheter of the present invention when it contains four channels. In the specific implementation process, the number of channels and their realized functions can be added or replaced according to the function of the catheter and the purpose of treatment, which can cover channels of any function during bronchiolar treatment.
- the balloon expansion channel is connected to the balloon inflation device through the catheter socket, and the balloon expansion channel 3 is in communication with the expansion balloon 6.
- the expansion balloon 6 is expanded under certain circumstances, so as to break open the blocked or narrowed part in the human body, and thus enable the catheter to advance smoothly.
- the positioning detection channel in the present invention is used for guidance during the insertion process, and can also be used for biopsy or fiber-optic endoscope insertion.
- the positioning detection channel 4 can be used as a guide wire channel, or a biopsy channel, or an endoscopic channel; a guide wire can be inserted into the positioning detection channel 4 to guide the insertion of a catheter; the interior of the positioning detection channel 4 can also be connected to a visualization system through a catheter socket , Insert the catheter under the instruction; the biopsy forceps can also be inserted into the positioning detection channel 4, and the detection system is connected through the catheter socket, after the catheter is inserted into the lung, the lung tissue sample is obtained.
- the positioning detection channel is a cylindrical channel; the inner diameter of the positioning detection channel is greater than 0.1 mm and less than or equal to 5.0 mm.
- the supply channel is connected to the supply device through the catheter socket.
- the supply device can be an oxygen source or a drug source.
- the supply channel includes a supply port, which is generally set at the end of the catheter; the supply channel and the supply port are used to supply oxygen and / Or supply of medicine. Specifically, the supply channel can atomize oxygen and spray it into the bronchus accurately. At the same time, patients in need of drug treatment can atomize and spray the medicine together with oxygen for local administration to minimize the effect of the drug. Damage caused by the system.
- the secretion drainage channel 1 is connected to a sputum suction machine or a pressure syringe through a catheter seat, and is used for perfusion and flushing of the bronchus or alveoli and sputum suction and liquid suction.
- the shape of the catheter and the channel inside the catheter in the present invention can be any shape, as long as it can achieve the purpose of treating bronchioles in the present invention.
- FIG. 2 is a schematic diagram of the internal cross-section corresponding to Section A in FIG.
- the substance removal channel 1, the supply channel 2 and the balloon expansion channel 3 are distributed between the positioning detection channel 4 and the outside of the catheter, resembling a fan-shaped distribution.
- the channel cross-sectional area of the secretion removal channel 1 is generally larger than the channel cross-sectional area of the balloon expansion channel 3 and the supply channel 2.
- the flushing air port 10, the expansion air port 9 and the supply air port 8 are all located on the outer surface of the catheter.
- the inner diameter of the positioning detection channel 4 is greater than 0.1 mm and less than or equal to 5.0 mm.
- a guide wire with a diameter of 0.05 mm or more and 5.0 mm or less can pass through the positioning detection channel.
- the start end of the positioning detection channel is connected to the visualization system, and the position of the catheter in the human body can be observed at any time, which is used to navigate the insertion process and position of the catheter, or the optical fiber endoscope is embedded in the positioning detection channel to guide the insertion of the catheter.
- the positioning detection channel 4 can also be connected to a detection device through the catheter base, which is used to perform a biopsy on the end position of the catheter, so as to know the condition of the patient at any time.
- the balloon expansion channel 3 also includes an expansion port 9, the front end of the balloon expansion channel 3 is connected to an air pump, and the expansion port 9 is located inside the balloon 6.
- the balloon 6 is located near the end of the catheter.
- the outer diameter of the balloon is larger than the outer diameter of other parts of the catheter when inflated.
- the outer diameter of the balloon can be expanded to different outer diameters under different inflation pressures.
- the narrow or blocked part of the human body expands.
- the expansion balloon can be a three-stage expansion balloon, the expansion pressure range of the three-stage expansion balloon is 3-18 atm, and the outer diameter of the third-stage expansion balloon is 3mm-24mm under inflated conditions.
- the expansion balloon can also be a single-stage expansion balloon, the expansion pressure range of the single-stage expansion balloon is 3-30 atm, and the outer diameter of the single-stage expansion balloon is 3 mm-30 mm under inflated conditions.
- the position and number of expansion ports in the balloon can be set according to specific requirements.
- the catheter in the present invention can be, but is not limited to, a polymer catheter, and the isolation material between the M channels inside the catheter is the same as that of the catheter; the hardness of the polymer catheter is greater than that of the balloon, so that the guide ribbon moves the catheter and the catheter drives the ball The sac is inserted into the bronchi of the lungs.
- the balloon in the present invention includes a bridge portion, a tapered portion and a cylindrical portion, wherein the bridge portions are located at both ends of the balloon and are fixedly connected to the outside of the catheter; the tapered portion connects the bridge portion and the cylindrical portion, and the outer diameter of the tapered portion It increases sequentially from the bridge portion to the cylindrical portion, and the outer diameter of the cylindrical portion is larger than the outer diameter of the bridge portion.
- the outer diameter of the bridging part is the same as the outer diameter of the catheter.
- the outer diameter of the cylindrical part needs to be larger than the outer diameter of the catheter. It needs to be slightly larger than the outer diameter of the catheter.
- the balloon In order to ensure that the balloon has a better flushing effect during the catheterization of the bronchioles, it can be set in the forward direction of the catheter.
- the function of the balloon is to break through the narrow or blocked part of the human body.
- the balloon does not need to be inflated. Only when obstacles or narrow parts are encountered during the advancement of the catheter, it needs to pass
- the air pump inflates the balloon. Since the expansion port is located inside the balloon, the balloon can be inflated by inflating, and the stenosis or blockage can be opened, so that the catheter can continue to advance.
- the balloon material can include but is not limited to one of nylon and its copolymers, PET (polyethylene terephthalate), PEBAX (polyether block polyamide) and other polymers or copolymers .
- the supply channel 2 also includes a supply port 8; the front end of the supply channel 2 is connected to an oxygen source, and the supply port is located at the front and/or rear end of the balloon in the catheter; the front end of the supply channel can be connected to a mechanical ventilator In, deliver atomized oxygen to specific parts of the human body.
- the front end of the supply channel can also be connected with a medicine source for supplying medicine to the lungs.
- patients who need medication can spray the medication together with oxygen for local administration to minimize the damage caused by the medication to the system.
- the position and number of air supply ports can be set according to specific requirements. Generally, air supply ports must be provided at the lower end of the balloon, and air supply ports can be selectively provided at the upper end of the balloon.
- the secretion removal channel 1 also includes a flushing port 10, the front end of the secretion removal channel is connected to a suction machine or a pressure syringe, and the flushing port is located at the distal end of the balloon in the catheter and is used to infuse the bronchi or alveoli Rinse and aspirate liquid.
- the secretions can be drawn out of the body through the sputum suction machine and secretion drainage channel, and the cleaning fluid such as normal saline can be pressed into the designated part through the secretion drainage channel. Flushing, promptly perfusing the inflammatory site of patients with new coronary pneumonia, excluding the bronchus, and draining the effusion in the alveoli can effectively alleviate the respiratory distress caused by the verification storm.
- the catheter end 7 can be set to a suitable hardness, which will not damage the human tissue, and can be smoothly inserted into the bronchioles under the guidance of the guide wire or the fiber optic endoscope.
- the range of the outer diameter of the catheter is about 2-10mm. As shown in Figure 4, because the outer diameter of the catheter is small, it can be easily passed through the tracheal intubation or endotracheal endoscope at the bedside.
- the introduction process is less traumatic and easy to operate, which not only shortens the time that medical staff are exposed to the virus, but also reduces the patient intubation
- the pain is especially suitable for the treatment of bronchiectasis.
- a method for oxygenation of the inner membrane lung by using the above catheter includes the following steps:
- the catheter is inserted into the bronchus of the lung through a tracheal intubation or a tracheal endoscope.
- the guide wire in the positioning detection channel is used to guide the forward direction of the catheter, and the balloon in the balloon expansion channel is used for expansion Narrow part
- the oxygen source atomizes the oxygen to the designated position through the supply channel.
- the supply channel can atomize the oxygen and spray it into the bronchus accurately.
- patients who need medication can spray the medication together with oxygen for local administration to minimize the damage caused by the medication to the system.
- the secretion drainage channel is connected with a sputum suction machine or a pressure syringe, which is used to flush and eliminate inflammatory secretions, and timely perfuse patients with new coronary pneumonia at the inflammation site and drain the bronchus. It is effective to drain the fluid in the alveoli Relieve the respiratory distress caused by the inflammatory storm.
- the invention organically combines the expansion balloon and the multi-lumen catheter technology, and has a small outer diameter, which can be directly inserted into the bronchioles of the lung under the guidance of a bronchoscope or an optical fiber endoscope; in the first aid, an expansion ball is used on the one hand
- the expansion and contraction of the sac opens up the blocked respiratory tract; on the other hand, through the secretion removal channel, the inflammatory discharge on the surface of the lung membrane can be sucked and flushed, and the oxygenation function of the lung membrane itself is restored.
- the supply channel is used to continuously supply oxygen and atomize.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Endoscopes (AREA)
Abstract
一种体内肺膜氧合多功能球囊扩张导管,包括位于导管近端的导管座(5)、位于导管远端的扩张球囊(6)和位于导管内的M个通道,M个通道至少包括球囊扩张通道(3)、定位检测通道(4)、供给通道(2)、分泌物排除通道(1);导管座(5)为多通道连接装置,M个通道分别通过导管座(5)连接至导管外部的治疗装置;导管插入至肺部细支气管(13)中,球囊扩张通道(3)用于扩张气道狭窄部分,定位检测通道(4)用于在插入过程中进行定位,供给通道(2)用于对患者进行持续给氧或给药,分泌物排除通道(5)用于排除气道中的分泌物。使用体内肺膜氧合多功能球囊扩张导管对肺炎病人,特别是新冠肺炎的急救时,可以同时实现气道扩张、给氧、吸痰及活检等措施同步进行,从而提高患者的生存率,降低肺部损害。
Description
优先权申明
本申请要求以2020年02月16日提交的申请号为US62977325(Intracorporeal Membrane Oxygenation Balloon Catheter System for Rapid Treatment of Novel Corona virus Disease(COVID-19))的美国专利申请的优先权。
本发明涉及膜肺氧合领域,具体涉及一种体内肺膜氧合多功能球囊扩张导管及方法。
2019年12月以来,新冠肺炎(COVID)疫情在世界各国陆续爆发,成为全世界亟需解决的重大医疗问题。导致新型冠状病毒肺炎流行是COVID-19(novel Coronavirus Disease 2019)冠状病毒,该病毒主要通过呼吸、消化道等途径进入人体后,与粘膜组织中血管紧张素转化酶2受体(ACE2)结合。ACE2受体广泛存在于人体各种粘膜细胞上。病毒入侵人体后,潜伏2-3周,之后迅速繁殖并激发患者的自身免疫机制而发病,初期类似于普通感冒症状,若不能有效控制,约20%的病人在1周左右转为重症。
重症病人主要起源于肺部炎症风暴导致的呼吸道快速衰竭,临床表现为极度呼吸困难及血氧饱和度快速下降。CT片显示双侧肺脏局限(早期)或弥漫(晚期)的毛片状阴影(白肺)。病理显示患者肺部开始由末端出现炎症反应,大量粘性炎症分泌物覆盖于细支气管及肺泡内(形成了CT片中看到的白肺)阻隔肺膜的正常的气体交换,导致血氧饱和度的快速下降。缺氧又进一步加剧其他器官 的损害,特别在老年人或同时患有其他疾病的患者尤为严重。
目前针对新冠病毒的治疗方法目前尚不完善,临床以各种支持治疗为主。针对危重症患者抢救措施仅有机械给氧和人工肺(ECMO)),且成功率非常低。最新的病理分析结果表明危重期患者肺部积攒的大量粘性分泌物阻塞呼吸道,阻碍肺脏通气功能,更使机械输氧无法到达支气管末梢而缺氧,末梢、肺泡长期缺氧使得肺泡损伤导致换气功能障碍。
目前较为通用的一种治疗方法为采用气管插管与呼吸机的维持治疗,当患者呼吸窘迫和氧饱和度下降时,辅助呼吸成为必要措施。由于新冠后期呼吸道表皮细胞分泌的黏蛋白增多,黏性分泌物阻塞气道从而使输入的氧气无法有效到达肺泡进行气体交换,造成肺泡损伤。此外,高流量、高压氧疗可能会将患者气道中堵塞的黏性分泌物向下呼吸道推送形成痰栓,进一步堵塞微细支气管,并可由此引发细菌感染。因此,在进行氧疗前,对患者气道中黏性分泌物进行稀释、溶解及排除是必要的。
目前较为通用的另一种治疗方法为体外肺膜氧合(ECMO)急救治疗;当呼吸机无法维持患者血氧水平时,患者需移入ICU进行体外膜肺氧合治疗(ECMO)。ECMO是在病人因各种原因导致无法有效接受机械通气时的最后治疗手段。使用时,在患者股静脉穿刺将血液引出并通过股静脉穿刺将血液引出并通ECMO机器对缺氧血液进行人工氧合,富氧血液再由颈机器对缺氧血液进行人工氧合,富氧血液再由颈静脉静脉输回患者心脏。ECMO代替出现呼吸衰竭,心脏衰竭的新冠患者的心肺功能进行血液净化氧合,从而使患者的心肺得到休息,争取自愈的时间。长期使用ECMO会对患者造成严重副作用,如凝血功能异常,肾脏功能损害,循环功能损伤(组织灌注能力下降)及呼吸功能损伤(灌 注肺)。ECMO的使用费用也是非常昂贵的,因其必须在ICU内使用,每日的ICU使用费用也非常可观(10万人民币左右次)。此设备价格高昂,小型城镇医院几乎没有配备。
目前临床上最常用的呼吸道介入治疗是经气管镜支气管球囊扩张治疗支气管狭窄。该方法通过支气管镜,将特殊的三级扩张球囊导管插到狭窄的呼吸道内进行逐级扩张。主要用于治疗手术瘢痕,肺移植吻合口、先天发育异常、肉芽肿疾病、气管插管术后等各种原因导致的支气管狭窄。多项临床数据证明球囊扩张术对良性气道狭窄的术后扩张率为90%-100%,且6个月后复狭窄率低于20%。
支气管肺泡灌洗术是在纤维支气管镜检查基础上发展起来的一项新技术,是通过支气管镜向肺内输入生理盐水后用负压吸出,收集肺泡表面液体进行多种肺部疾病,如肺泡炎、肺纤维化、石棉肺、肺癌、肺囊虫病、肺泡蛋白沉积症进行鉴别诊断的一种手段,近年来也逐渐用于治疗重症呼吸衰竭患者,术后患者临床表现均有提升,氧饱和度及氧分压明显上升,同时二氧化碳分压显著下降。
介入治疗在目前的新冠肺炎病人治疗中还未见报道,这是由于国际范围内用于肺部介入治疗的任何单一器械功能有限,无法满足治疗重症新冠肺炎患者之复杂、快速演变的病程需要。最新尸检结果表明:造成目前治疗效果不好的主要原因是肺组织内大量的粘性炎症分泌物堆积在支气管内及肺底部的肺膜表面,阻碍着肺膜的正常氧合。因而快速有效的清理支气管及肺膜上的“淤泥”是新冠肺炎急救的关键。目前支气管镜及常规吸痰技术虽然可以用来清洗排痰,但仅限于高位大气管,且功能单一,对新冠病人的肺部炎症风暴基本无效,因而临床上急需一集“气管扩张、排痰、肺泡灌洗、持续给氧、雾化与给药”于一体的多功能器械用于新冠病人的急救。
发明内容
针对现有技术的不足,本发明的目的旨在提供一种体内肺膜氧合多功能球囊扩张导管及使用方法。
为实现上述目的,本发明采用如下技术方案:一种体内肺膜氧合多功能球囊扩张导管,包括位于导管近端的导管座、位于导管远端的扩张球囊和位于导管内的M个通道,所述M个通道至少包括球囊扩张通道、定位检测通道、供给通道、分泌物排除通道;M为大于等于4的整数;所述导管座为多通道连接装置,所述M个通道分别通过导管座连接至导管外部的治疗装置;
所述导管插入至肺部细支气管中,所述球囊扩张通道用于扩张气道狭窄部分,所述定位检测通道用于在插入过程中进行定位或检测;所述供给通道用于对患者进行持续给氧或给药,所述分泌物排除通道用于排除气道中的分泌物。
进一步的,所述球囊扩张通道通过导管座连接球囊充气装置;所述扩张球囊内部包括扩张气口;
所述分泌物排除通道通过导管座连接吸痰机或压力注射器,所述分泌物排除通道包括冲洗气口;
所述供给通道通过导管座连接供给装置,所述供给通道包括供给气口;
所述定位检测通道贯穿导管两端,可供导引导丝、活检钳子或光纤内窥镜通过。
进一步的,所述分泌物排除通道的截面面积大于所述球囊扩张通道和供给通道的截面面积。
进一步的,所述定位检测通道为圆柱状通道;所述定位检测通道的内径大于0.1mm,且小于等于5.0mm
进一步的,所述扩张球囊为三级扩张球囊,所述三级扩张球囊的扩张压力范围为3-18atm,所述三级扩张球囊外径在充气条件下为3mm-24mm。
进一步的,所述扩张球囊为单级扩张球囊,所述单级扩张球囊的扩张压力范围为3-30atm,所述单级扩张球囊外径在充气条件下为3mm-30mm。
进一步的,所述导管为高分子材料导管,且导管内部M个通道之间的隔离材质与导管材质相同。
进一步的,所述导管座连接鲁尔接头,所述鲁尔接头和导管座使得M个通道与外部相对应的治疗装置连接。
一种采用上述的导管进行体内膜肺氧合的方法,包括如下步骤:
S01:导管通过气管插管或者通过气管内窥镜插入至肺部支气管中,在插入过程中,定位检测通道用于引导导管的前进方向,球囊扩张通道控制球囊对狭窄部分进行扩张;
S02:所述导管到达指定位置之后,供给通道对指定位置进行给氧或给药;
S03:所述导管到达指定位置之后,分泌物排除通道用于对指定位置进行灌注冲洗及吸痰吸液。
本发明的有益效果在于:本发明将扩张球囊与多腔导管技术有机结合,且外径较小,可在支气管镜或光纤内窥镜的引导下被直接插入到肺部支气管;在急救时,一方面用扩张球囊的扩张打通阻塞的呼吸道;另一方面,通过分泌物排除通道可以抽吸、冲洗肺膜表面炎症排出物,恢复肺膜自身的氧合功能,同时用供给通道持续给氧、雾化治疗或连接人工呼吸机,最大程度的保证病人的氧气供应,从而在一根导管上实现全部位(大、小支气管、肺泡)与全方位(气管扩张、排痰、给氧与给药)的急救;本产品还可适用于治疗各种原因导致的肺炎(如支原 体肺炎,结核导致的呼吸道狭窄、肺炎)、矽肺等。
附图1为本发明导管的结构示意图;
附图2为本发明导管中各个通道的示意图;
附图3为本发明导管中球囊部位的示意图;
附图4为本发明中导管插入肺部下呼吸道时球囊位置示意图;
附图5为本发明中导管座的实物图;
附图6本发明中导管的实物图。
附图标记:1分泌物排除通道,2供给通道,3球囊扩张通道,4定位检测通道,5导管座,6扩张球囊,7导管末端,8供给气口,9扩张气口,10冲洗气口,11气管,12主支气管,13细支气管。
下面,结合附图以及具体实施方式,对本发明做进一步描述:
请参阅附图1-5,一种体内肺膜氧合多功能球囊扩张导管,包括位于导管近端的导管座5、位于导管远端的扩张球囊6和位于导管内的M个通道,其中,导管座为多通道连接装置,M个通道分别通过导管座连接至导管外部的治疗装置。如附图5所示,导管座上还可以连接鲁尔接头,鲁尔接头和导管座使得M个通道与外部相对应的治疗装置连接,并使得外部对应的治疗装置之间可以实现切换。本发明中M个通道至少包括球囊扩张通道3、定位检测通道4、供给通道2和分泌物排除通道;M为大于等于4的整数。如附图6所示,为本发明导管包含四个通道时的实物图。在具体实施过程中,通道的个数以及其实现的功能可以根 据导管的功能以及治疗目的进行增加或者更换,可以涵盖细支气管治疗过程中任意功能的通道。
球囊扩张通道通过导管座连接球囊充气装置,且球囊扩张通道3与扩张球囊6相通,扩张球囊内部包括扩张气口,球囊充气装置通过球囊扩张通道和扩张气口将气体充至扩张球囊中,使得扩张球囊6在特定情况下进行扩张,从而冲开人体中堵塞或者狭窄部位,进而使得导管顺利前进。
本发明中定位检测通道用于在插入过程中进行指引,也可用于活检或光纤内窥镜插入。具体的,定位检测通道4可以作为导丝通道,或者活检通道,或者内窥通道;定位检测通道4内部可插入导丝,引导导管的插入;定位检测通道4内部也可通过导管座连接可视化系统,在指示下插入导管;定位检测通道4内部还可以插入活检钳,且通过导管座连接检测系统,在导管插入肺部后,获取肺部组织样本。定位检测通道为圆柱状通道;定位检测通道的内径大于0.1mm,且小于等于5.0mm。当定位检测通道4连接可视化系统时,用于对导管的前进方向及位置进行导航;当定位检测通道4连接检测系统时,用于对导管末端位置进行活检,随时了解病人的状况。
供给通道通过导管座连接供给装置,供给装置可以为氧气源或者药物源,供给通道包括供给气口,供给气口一般设置在导管末端;供给通道和供给气口用于对导管所到达的部位进行供氧和/或供药,具体的,供给通道可将氧气雾化后精准喷至支气管内,同时,需药物治疗的患者可将药物与氧气一起雾化喷入进行局部给药,以最大程度减轻药物对系统造成的损伤。
分泌物排除通道1通过导管座连接吸痰机或压力注射器,用于对支气管或肺泡进行灌注冲洗及吸痰吸液。
本发明中导管以及导管内部的通道形状可以为任意形状,只需能够实现本发明中对细支气管治疗的目的即可。作为一种优选的实施例,请参阅附图2,附图2中示例为附图1中SectionA部位对应的内部截面示意图:导管可以设置为圆柱状导管,定位检测通道4为圆柱状通道,分泌物排除通道1、供给通道2和球囊扩张通道3分布在定位检测通道4和导管外侧之间,类似扇形分布。分泌物排除通道1的通道截面面积通常大于球囊扩张通道3和供给通道2的通道截面面积。冲洗气口10、扩张气口9和供给气口8均位于导管的外侧表面。
本发明中定位检测通道4的内径大于0.1mm,且小于等于5.0mm。可以使得直径为0.05mm以上,5.0mm以下的导丝通过定位检测通道。定位检测通道起始端连接可视化系统,可以随时观测到导管在人体中的位置,用于对导管的插入过程以及位置进行导航,或者定位检测通道中内嵌光纤内窥镜,以引导导管的插入。同时,定位检测通道4通过导管座还可以连接检测装置,用于对导管末端位置进行活检,随时了解病人的状况。
请参阅附图3,球囊扩张通道3还包括扩张气口9,球囊扩张通道3的前端连接气泵,扩张气口9位于球囊6内部。球囊6位于导管中间靠末端的位置,球囊的外径在充气状态下大于导管其他部分的外径,球囊的外径在不同充气气压下,可以扩张为不同外径大小,用于对人体中狭窄或者堵塞部分进行扩张。实际使用中,扩张球囊可以为三级扩张球囊,三级扩张球囊的扩张压力范围为3-18atm,三级扩张球囊外径在充气条件下为3mm-24mm。扩张球囊还可以为单级扩张球囊,单级扩张球囊的扩张压力范围为3-30atm,单级扩张球囊外径在充气条件下为3mm-30mm。扩张气口在球囊中的位置以及个数可以根据具体需求进行设定。
本发明中导管可以但不限于为高分子导管,且导管内部M个通道之间的隔离材质与导管材质相同;高分子导管的硬度大于球囊的硬度,从而使得导丝带动导管,导管带动球囊插入至肺部支气管中。优选的,本发明中球囊包括桥接部、渐变部和圆柱部,其中,桥接部分别位于球囊的两端,固定连接在导管外侧;渐变部连接桥接部和圆柱部,渐变部的外径从桥接部至圆柱部依次增大,圆柱部的外径大于桥接部的外径。桥接部的外径与导管外径相同,圆柱部的外径需要大于导管的外径,具体大多少,可以根据球囊的充气状态进行决定,当球囊未被充气时,球囊外径只需要稍大于导管外径即可。为了在导管插入细支气管过程中,确保球囊获得更好的冲开效果,可以设置在导管前进方向上,桥接部的长度:渐变部的长度:圆柱状的长度=1:2:7;该长度比例下可以确保球囊被牢固固定在导管外侧,且在冲开狭窄部位时,渐变部可以起到对狭窄部位的缓冲作用,避免圆柱状直接冲击狭窄部件,造成人体组织的损伤。
球囊的作用是为了冲开人体中狭窄或者堵塞的部分,在导管正常的前进过程中,是不需要对球囊进行充气的,只有在导管前进过程中遇到障碍或者狭窄部件时,需要通过气泵对球囊进行充气,由于扩张气口位于球囊内部,通过充气,可以使得球囊膨胀,冲开狭窄或者堵塞部位,使得导管继续前进。球囊材料可以包括但不限于尼龙及其共聚物、PET(polyethylene terephthalate,聚对苯二甲酸乙二醇酯)、PEBAX(聚醚嵌段聚酰胺)和其他聚合物或共聚物中的一种。
请继续参阅附图3,供给通道2还包括供给气口8;供给通道2的前端连接氧气源,供给气口位于导管中球囊的前端和/或后端;供给通道的前端可以连接到机械呼吸机中,为人体中特定部位输送雾化氧。供给通道前端还可以连接药物源,用于对肺部进行供药。同时,需药物治疗的患者可将药物与氧气一起雾化喷入进 行局部给药,以最大程度减轻药物对系统造成的损伤。供给气口的位置和个数可以根据具体需求进行设置,通常,在球囊的下端必定设置供给气口,在球囊的上端可以选择性设置供给气口。
请继续参阅附图3,分泌物排除通道1还包括冲洗气口10,分泌物排除通道前端连接吸痰机或压力注射器,冲洗气口位于导管中球囊的远端,用于对支气管或肺泡进行灌注冲洗及吸痰吸液。当导管所到区域有炎症时,可能会存在炎症分泌物等,可以通过吸痰机和分泌物排除通道对分泌物抽出体外,并将生理盐水等清洗液通过分泌物排除通道压入指定部位进行冲洗,及时对新冠肺炎患者进行炎症部位灌注并排除支气管,排出肺泡内积液能有效缓解验证风暴带来的呼吸窘迫。
为了保持导管远端更好地在人体中前进插入,可以将导管末端7设置为合适的硬度,既不会损伤人体组织,又能在导丝或光纤内窥镜指引下顺利插入细支气管中。导管外径周长范围为2-10mm左右,如附图4所示,由于导管外径较小,可在床边轻松通过气管插管或气管内窥镜,在导丝或光纤内窥镜的引导下依次经过气管11和主支气管12进入至肺部的任何细支气管13或者肺泡中;导入过程创伤小,操作容易,这既缩短了医护人员暴露在病毒下的时间,也减低了病人插管的痛苦,尤其适合于细支气管的扩张治疗。
一种采用上述导管进行体内膜肺氧合的方法,包括如下步骤:
S01:导管通过气管插管或者通过气管内窥镜插入至肺部支气管中,在插入过程中,定位检测通道中的导丝用于引导导管的前进方向,球囊扩张通道中球囊用于扩张狭窄部分;
S02:导管到达指定位置之后,氧气源通过供给通道对指定位置进行雾化给 氧,供给通道可将氧气雾化后精确喷至支气管内。同时,需药物治疗的患者可将药物与氧气一起雾化喷入进行局部给药,以最大程度减轻药物对系统造成的损伤
S03:导管到达指定位置之后,分泌物排除通道与吸痰机或压力注射器连接,用于冲洗、排除炎症分泌物,及时对新冠肺炎患者进行炎症部位灌注并排出支气管,排出肺泡内积液能有效减缓炎症风暴带来的呼吸窘迫。
本发明将扩张球囊与多腔导管技术有机结合,且外径较小,可在支气管镜或光纤内窥镜的引导下被直接插入到肺部细支气管;在急救时,一方面用扩张球囊的扩张和收缩打通阻塞的呼吸道;另一方面,通过分泌物排除通道可以抽吸、冲洗肺膜表面炎症排出物,恢复肺膜自身的氧合功能,同时用供给通道持续给氧、雾化治疗或连接人工呼吸机,最大程度的保证病人的氧气供应,从而在一根导管上实现全部位(大、小支气管、肺泡)与全方位(气管扩张、排痰、给氧与给药)的急救;本产品还可适用于治疗各种原因导致的肺炎(如支原体肺炎,结核导致的呼吸道狭窄、肺炎)、矽肺等。
对本领域的技术人员来说,可根据以上描述的技术方案以及构思,做出其它各种相应的改变以及形变,而所有的这些改变以及形变都应该属于本发明权利要求的保护范围之内。
Claims (9)
- 一种体内肺膜氧合多功能球囊扩张导管,其特征在于,包括位于导管近端的导管座、位于导管远端的扩张球囊和位于导管内的M个通道,所述M个通道至少包括球囊扩张通道、定位检测通道、供给通道、分泌物排除通道;M为大于等于4的整数;所述导管座为多通道连接装置,所述M个通道分别通过导管座连接至导管外部的治疗装置;所述导管插入至肺部细支气管中,所述球囊扩张通道用于扩张气道狭窄部分,所述定位检测通道用于在插入过程中进行定位或检测,所述供给通道用于对患者进行持续给氧或给药,所述分泌物排除通道用于排除气道中的分泌物。
- 根据权利要求1所述的一种体内肺膜氧合多功能球囊扩张导管,其特征在于,所述球囊扩张通道通过导管座连接球囊充气装置;所述扩张球囊内部包括扩张气口;所述分泌物排除通道通过导管座连接吸痰机或压力注射器,所述分泌物排除通道包括冲洗气口;所述供给通道通过导管座连接供给装置,所述供给通道包括供给气口;所述定位检测通道贯穿导管两端,可供导引导丝、活检钳子或光纤内窥镜通过。
- 根据权利要求2所述的一种体内肺膜氧合多功能球囊扩张导管,其特征在于,所述分泌物排除通道的截面面积大于所述球囊扩张通道和供给通道的截面面积。
- 根据权利要求1所述的一种体内肺膜氧合多功能球囊扩张导管,其特征在于,所述定位检测通道为圆柱状通道;所述定位检测通道的内径大于0.1mm,且小于等于5.0mm。
- 根据权利要求1所述的一种体内肺膜氧合多功能球囊扩张导管,其特征在于,所述扩张球囊为三级扩张球囊,所述三级扩张球囊的扩张压力范围为3-18atm,所述三级扩张球囊外径在充气条件下为3mm-24mm。
- 根据权利要求1所述的一种体内肺膜氧合多功能球囊扩张导管,其特征在于,所述扩张球囊为单级扩张球囊,所述单级扩张球囊的扩张压力范围为3-30atm,所述单级扩张球囊外径在充气条件下为3mm-30mm。
- 根据权利要求1所述的一种体内肺膜氧合多功能球囊扩张导管,其特征在于,所述导管为高分子材料导管,且导管内部M个通道之间的隔离材质与导管材质相同。
- 根据权利要求1所述的一种体内肺膜氧合多功能球囊扩张导管,其特征在于,所述导管座上连接鲁尔接头,所述鲁尔接头和导管座使得M个通道与外部相对应的治疗装置连接。
- 一种采用权利要求1所述的导管进行体内膜肺氧合的方法,其特征在于,包括如下步骤:S01:导管通过气管插管或者通过气管内窥镜插入至肺部支气管中,在插入过程中,定位检测通道用于引导导管的前进方向,球囊扩张通道控制球囊对狭窄部分进行扩张;S02:所述导管到达指定位置之后,供给通道对指定位置进行给氧或给药;S03:所述导管到达指定位置之后,分泌物排除通道用于对指定位置进行灌注冲洗及吸痰吸液。
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP21754312.3A EP4104889A4 (en) | 2020-02-16 | 2021-02-05 | MULTIFUNCTIONAL BALLOON DILATION CATHETER FOR INTRACORPOREAL MEMBRANE OXYGENATION AND METHOD OF USE THEREOF |
US17/888,187 US20230023758A1 (en) | 2020-02-16 | 2022-08-15 | Multifunctional balloon dilatation catheter for intracorporeal membrane oxygenation and usage method therefor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202062977325P | 2020-02-16 | 2020-02-16 | |
US62/977,325 | 2020-02-16 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US17/888,187 Continuation US20230023758A1 (en) | 2020-02-16 | 2022-08-15 | Multifunctional balloon dilatation catheter for intracorporeal membrane oxygenation and usage method therefor |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2021160030A1 true WO2021160030A1 (zh) | 2021-08-19 |
Family
ID=76006972
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CN2021/075458 WO2021160030A1 (zh) | 2020-02-16 | 2021-02-05 | 一种体内肺膜氧合多功能球囊扩张导管及使用方法 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20230023758A1 (zh) |
EP (1) | EP4104889A4 (zh) |
CN (1) | CN112843436A (zh) |
WO (1) | WO2021160030A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN115212377A (zh) * | 2022-08-09 | 2022-10-21 | 西安国际医学中心有限公司 | 一种妇科护理宫腔给药器 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN202802443U (zh) * | 2012-09-24 | 2013-03-20 | 南京双威生物医学科技有限公司 | 一种多功能气管导管 |
CN104434258A (zh) * | 2014-11-28 | 2015-03-25 | 苏州亘科医疗科技有限公司 | 一种多功能球囊扩张导管 |
CN204995953U (zh) * | 2015-07-17 | 2016-01-27 | 罗航宇 | 气管内插管 |
JP2019093071A (ja) * | 2017-11-28 | 2019-06-20 | クリエートメディック株式会社 | バルーンカテーテル |
CN209827881U (zh) * | 2018-08-21 | 2019-12-24 | 珠海市美浩科技有限公司 | 一种多腔气管插管 |
CN209899351U (zh) * | 2019-03-19 | 2020-01-07 | 牛斌 | 一种肺段灌洗管 |
US20200030557A1 (en) * | 2018-07-27 | 2020-01-30 | Guillermo L. Pol | Medical tubes for selective mechanical ventilation of the lungs |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4584998A (en) * | 1981-09-11 | 1986-04-29 | Mallinckrodt, Inc. | Multi-purpose tracheal tube |
AUPP229498A0 (en) * | 1998-03-11 | 1998-04-09 | Oldfield Family Holdings Pty Limited | Endotracheal tube for selective bronchial occlusion |
US6610043B1 (en) * | 1999-08-23 | 2003-08-26 | Bistech, Inc. | Tissue volume reduction |
US6398775B1 (en) * | 1999-10-21 | 2002-06-04 | Pulmonx | Apparatus and method for isolated lung access |
US6835189B2 (en) * | 2002-10-15 | 2004-12-28 | Scimed Life Systems, Inc. | Controlled deployment balloon |
US7478636B2 (en) * | 2005-08-08 | 2009-01-20 | Kimberly-Clark Worldwide, Inc. | Multilumen tracheal catheter to prevent cross contamination |
CN102125721A (zh) * | 2011-03-10 | 2011-07-20 | 微创医疗器械(上海)有限公司 | 一种新型介入医疗器械 |
US10898700B2 (en) * | 2012-10-26 | 2021-01-26 | Urotronic, Inc. | Balloon catheters for body lumens |
CN203342179U (zh) * | 2013-06-25 | 2013-12-18 | 邢西迁 | 一种支气管镜下气道扩张球囊导管 |
CN103893900A (zh) * | 2014-04-14 | 2014-07-02 | 李建树 | 一种高弹球囊及其制造方法、以及带该球囊的支气管导管 |
CN105705192A (zh) * | 2014-07-22 | 2016-06-22 | 潘湘斌 | 用于超声引导下经皮肺动脉瓣球囊扩张术的新型球囊导管 |
US10413408B2 (en) * | 2015-08-06 | 2019-09-17 | Evalve, Inc. | Delivery catheter systems, methods, and devices |
CN105854143B (zh) * | 2016-04-18 | 2019-02-19 | 江苏立峰生物科技有限公司 | 一种加药吸痰测温型气管插管 |
CN206391345U (zh) * | 2016-05-31 | 2017-08-11 | 李坤营 | 支气管肺泡灌洗及肺脓腔灌洗注药用球囊导管 |
US10799092B2 (en) * | 2016-09-19 | 2020-10-13 | Covidien Lp | System and method for cleansing segments of a luminal network |
EP3781011A4 (en) * | 2018-04-17 | 2022-01-12 | The Board of Trustees of the Leland Stanford Junior University | AIRWAY VISUALIZATION SYSTEM |
CN108498928B (zh) * | 2018-05-08 | 2023-11-21 | 复旦大学附属金山医院 | 一种可在纤支镜引导下行支气管堵塞的气管插管套件 |
CN210096520U (zh) * | 2019-05-24 | 2020-02-21 | 上海蕴箬生物科技有限公司 | 一种肺泡灌洗球囊导管 |
-
2021
- 2021-01-15 CN CN202110057974.3A patent/CN112843436A/zh active Pending
- 2021-02-05 WO PCT/CN2021/075458 patent/WO2021160030A1/zh unknown
- 2021-02-05 EP EP21754312.3A patent/EP4104889A4/en active Pending
-
2022
- 2022-08-15 US US17/888,187 patent/US20230023758A1/en active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN202802443U (zh) * | 2012-09-24 | 2013-03-20 | 南京双威生物医学科技有限公司 | 一种多功能气管导管 |
CN104434258A (zh) * | 2014-11-28 | 2015-03-25 | 苏州亘科医疗科技有限公司 | 一种多功能球囊扩张导管 |
CN204995953U (zh) * | 2015-07-17 | 2016-01-27 | 罗航宇 | 气管内插管 |
JP2019093071A (ja) * | 2017-11-28 | 2019-06-20 | クリエートメディック株式会社 | バルーンカテーテル |
US20200030557A1 (en) * | 2018-07-27 | 2020-01-30 | Guillermo L. Pol | Medical tubes for selective mechanical ventilation of the lungs |
CN209827881U (zh) * | 2018-08-21 | 2019-12-24 | 珠海市美浩科技有限公司 | 一种多腔气管插管 |
CN209899351U (zh) * | 2019-03-19 | 2020-01-07 | 牛斌 | 一种肺段灌洗管 |
Non-Patent Citations (1)
Title |
---|
See also references of EP4104889A4 * |
Also Published As
Publication number | Publication date |
---|---|
EP4104889A4 (en) | 2024-05-15 |
EP4104889A1 (en) | 2022-12-21 |
US20230023758A1 (en) | 2023-01-26 |
CN112843436A (zh) | 2021-05-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11744994B2 (en) | Devices and method for maxillary sinus lavage | |
US9095646B2 (en) | Devices and methods for transnasal dilation and irrigation of the sinuses | |
US10898693B2 (en) | Nasal delivery of agents with nested balloon catheter | |
JP6389433B2 (ja) | 気管支内チューブ | |
US4969878A (en) | Thick-walled flexible probe for insertion in the trachea or respectively in the bronchial system | |
US4584998A (en) | Multi-purpose tracheal tube | |
CA2620146C (en) | Multilumen tracheal catheter with rinse lumen | |
EP1658866A1 (en) | Pulmonary drug delivery | |
EP1658868A1 (en) | Devices for controlling collateral ventilation | |
JP2006142028A (ja) | 局所胸膜癒着排出装置 | |
US20140305430A1 (en) | Probe for medical use | |
WO2021160030A1 (zh) | 一种体内肺膜氧合多功能球囊扩张导管及使用方法 | |
CN215309538U (zh) | 一种体内肺膜氧合多功能球囊扩张导管 | |
Downing et al. | Excision of subglottic stenosis with the urethral resectoscope | |
CN211962767U (zh) | 一种双腔支气管导管 | |
CN219354969U (zh) | 一种具有双摄像头的可视双腔支气管导管 | |
CN115581838B (zh) | 一种气管单侧支气管导管 | |
CN219462230U (zh) | 一种双管腔支气管封堵器 | |
Wood | Whole-lung lavage | |
CN117598653A (zh) | 一种预防大出血的支气管套管及其使用方法 | |
ALBERT | A Simple Method for Differential Block-Inflation in Anesthesia for Lung Surgery | |
MXPA06001220A (en) | A probe for medical use | |
JPWO2012124560A1 (ja) | 内視鏡装置 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 21754312 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2021754312 Country of ref document: EP Effective date: 20220916 |