WO2021153651A1 - Composition d'écran solaire - Google Patents

Composition d'écran solaire Download PDF

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Publication number
WO2021153651A1
WO2021153651A1 PCT/JP2021/002968 JP2021002968W WO2021153651A1 WO 2021153651 A1 WO2021153651 A1 WO 2021153651A1 JP 2021002968 W JP2021002968 W JP 2021002968W WO 2021153651 A1 WO2021153651 A1 WO 2021153651A1
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mass
oil
sunscreen composition
content
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PCT/JP2021/002968
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English (en)
Japanese (ja)
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進宇 鄭
百合香 西田
宏一 長井
昭夫 那須
隆志 福原
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株式会社資生堂
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Publication of WO2021153651A1 publication Critical patent/WO2021153651A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
    • A61K8/894—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone modified by a polyoxyalkylene group, e.g. cetyl dimethicone copolyol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • the present invention relates to a sunscreen composition.
  • a sunscreen composition As a sunscreen composition, a water-in-oil type or an oil-in-water type containing an ultraviolet protection functional component such as an inorganic fine powder is known. Further, those containing silicone oil, polyglycerin-modified silicone, or the like are also known for the purpose of improving usability and stability over time (for example, Patent Document 1).
  • a sunscreen composition having a high UV protection function has been demanded, but in order to improve the UV protection function, it is generally necessary to increase the content of a UV scattering agent or a UV absorber.
  • a UV scattering agent or a UV absorber depending on the content of the UV scatterer and the UV absorber, the dispersibility of the UV scatterer or the solubility of the UV absorber in the cosmetics becomes poor, and the UV absorber or the UV scatterer sufficiently functions. It may not be possible to demonstrate.
  • the rheological physical properties (viscosity, etc.) of the sunscreen composition may change, impairing the usability.
  • the sunscreen composition according to one aspect of the present invention contains (A) polar oil, (B) silicone oil, (C) inorganic fine powder, and (D) polyglycerin-modified silicone.
  • the value of the ratio of the content of the silicone oil (B) to the content of the polar oil (A) is 0.01 or more and 0.75 or less.
  • a sunscreen composition that exhibits a good ultraviolet protection function and is also excellent in usability.
  • Polar oil is a lipophilic component generally used in cosmetics and has a relatively high polarity. Further, as is clear from the following examples, the polar oil (A) may be a solid or a liquid at room temperature (25 ° C.).
  • the (A) polar oil used in the sunscreen composition according to this embodiment may contain an ultraviolet absorber.
  • the polar oil (A) may contain a polar oil having an ultraviolet absorbing function (hereinafter, may be referred to as an ultraviolet absorbing polar oil).
  • an ultraviolet absorbing polar oil When the polar oil contains an ultraviolet absorber, the ultraviolet protection effect of the sunscreen composition can be enhanced.
  • the ultraviolet absorber (ultraviolet absorbing polar oil) contained in the polar oil is not particularly limited, and for example, a benzoic acid derivative, a salicylic acid derivative, a silicic acid derivative, a dibenzoylmethane derivative, and a ⁇ , ⁇ -diphenylacrylate derivative.
  • benzoic acid derivative examples include p-aminobenzoic acid (PABA) ethyl, ethyl-dihydroxypropyl PABA, ethylhexyl-dimethyl PABA, glyceryl PABA, PEG-25 PABA, diethylaminohydroxybenzoyl hexyl benzoate and the like.
  • PABA p-aminobenzoic acid
  • salicylic acid derivatives include homosalate, ethylhexyl salicylate (octyl salicylate), dipropylene glycol salicylate, and TEA salicylate.
  • Examples of the cinnamic acid derivative include octylmethoxycinnamate (ethylhexyl methoxycinnamate), isopropyl methoxycinnamate, isoamyl methoxycinnamate, cinoxate, DEA methoxycinnamate, diisopropyl methylsilicate, and glyceryl-ethylhexanoate-. Examples thereof include dimethoxycinnamate and di- (2-ethylhexyl) -4'-methoxybenzalmalonate.
  • dibenzoylmethane derivative examples include butylmethoxide benzoylmethane (4-tert-butyl-4'-methoxydibenzoylmethane).
  • ⁇ and ⁇ -diphenylacrylate derivatives examples include octocrylene and the like.
  • benzophenone derivative examples include benzophenone-1, benzophenone-2, benzophenone-3 or oxybenzone, benzophenone-4, benzophenone-5, benzophenone-6, benzophenone-8, benzophenone-9, benzophenone-12 and the like.
  • benzylidene sulphate derivative examples include 3-benzylidene sulphate, 4-methylbenzylidene sulphonic acid, benzylidene sulphonic acid, sulphonic acid sulphate benzalkonium, terephthalilidene sulphonic acid, polyacrylamide methylbenzylidene sulphonic acid and the like.
  • phenylbenzimidazole derivative examples include phenylbenzoimidazole sulfonic acid and disodium phenyldibenzoimidazole tetrasulfonate.
  • triazine derivatives examples include anisotriazine (bisethylhexyloxyphenol methoxyphenyl triazine), ethylhexyltriazone, diethihexylbutamidotriazine, and 2,4,6-tris (diisobutyl-4'-aminobenzalmaronate) -s.
  • anisotriazine bisethylhexyloxyphenol methoxyphenyl triazine
  • ethylhexyltriazone diethihexylbutamidotriazine
  • 2,4,6-tris diisobutyl-4'-aminobenzalmaronate
  • phenylbenzotriazole derivative examples include drometrizoletrisiloxane and methylenebis (benzotriazolyltetramethylbutylphenol).
  • Examples of the anthranil derivative include menthyl anthranilate.
  • Examples of the imidazoline derivative include ethylhexyldimethoxybenzylidene dioxoimidazolidine propionate.
  • Examples of the benzalmalonate derivative include polyorganosiloxane having a benzalmalonate functional group.
  • Examples of the 4,4-diarylbutadiene derivative include 1,1-dicarboxy (2,2'-dimethylpropyl) -4,4-diphenylbutadiene.
  • silicone derivative examples include polysilicone-14 and polysilicone-15.
  • the above-mentioned ultraviolet absorbing polar oil may be used alone or in combination of two or more. Further, it is preferable to use a plurality of ultraviolet absorbing polar oils having different compounds as the base of the derivative in combination because a wide range of ultraviolet protective action can be obtained.
  • a dibenzoylmethane derivative, a silicone derivative, a triazine derivative, a benzoic acid derivative, and a salicylic acid derivative can be used in combination.
  • octocrylene polysilicone-15, anisotriazine (bisethylhexyloxyphenol methoxyphenyltriazine), diethylaminohydroxybenzoyl hexyl benzoate, and ethylhexyl salicylate (octyl salicylate) in combination.
  • anisotriazine bisethylhexyloxyphenol methoxyphenyltriazine
  • diethylaminohydroxybenzoyl hexyl benzoate diethylaminohydroxybenzoyl hexyl benzoate
  • ethylhexyl salicylate octyl salicylate
  • the type of ultraviolet absorbing polar oil used in this embodiment is not particularly limited. However, depending on the type of ultraviolet absorber, there are some that can be affected by light (ultraviolet rays) and have a reduced ultraviolet absorbing action when used continuously. Therefore, from the viewpoint of improving the stability to light, the sunscreen composition according to this embodiment preferably contains octylmethoxycinnamate in an amount of 3% by mass or less, and more preferably 1% by mass or less. In addition, the sunscreen composition according to this embodiment preferably contains substantially no octylmethoxycinnamate, and more preferably no octylmethoxycinnamate.
  • the content of the ultraviolet absorbing polar oil which is a cinnamic acid derivative in the sunscreen composition is preferably 3% by mass or less, and the sunscreen composition is a cinnamic acid. It is more preferable that the acid derivative is substantially or not contained at all.
  • substantially not contained or “substantially not contained” means that the content with respect to the total amount of the composition or the amount of a predetermined portion in the composition is preferably 0.1% by mass or less. , More preferably 0.05% by mass or less, still more preferably 0.01% by mass or less, still more preferably 0.001% by mass or less.
  • the polar oil may contain only the ultraviolet absorbing polar oil, or may contain the ultraviolet absorbing polar oil and the polar oil having no ultraviolet absorbing function.
  • polar oils having no ultraviolet absorbing function include ester oils, ether oils, higher fatty acids, higher alcohols, liquid fats and oils, solid fats and oils, amide compounds, higher amines, triglyceride oils, sugars and the like. Ester oils are preferably used because they can provide ease of use and a good feeling of use.
  • the ester oil may be a monoester, a diester, a carbonic acid ester, or the like.
  • Specific examples of the ester oil include isononyl isononanoate, isopropyl myristate, cetyl 2-ethylhexanate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, and dimethyl.
  • the above ester oil may be used alone or in combination of two or more.
  • the polar oil (A) preferably contains an ultraviolet absorbing polar oil and an ester oil.
  • both aliphatic ester oils and aromatic ester oils are mentioned as specific examples of the above-mentioned ester oils, they are included in (A) polar oils because they can improve the stability of the dosage form of the sunscreen composition.
  • higher fatty acids include lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, undecylene acid, tollic acid, isostearic acid, linoleic acid, linoleic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid. (DHA) and the like.
  • higher alcohols include linear alcohols (eg, lauryl alcohols, cetyl alcohols, stearyl alcohols, behenyl alcohols, myristyl alcohols, oleyl alcohols, cetostearyl alcohols, etc.), and branched alcohols (eg, monostearyl glycerin ethers (eg, monostearyl glycerin ethers).
  • Bacil alcohol -2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, etc.
  • linear alcohols eg, lauryl alcohols, cetyl alcohols, stearyl alcohols, behenyl alcohols, myristyl alcohols, oleyl alcohols, cetostearyl alcohols, etc.
  • branched alcohols eg, monostearyl glycerin ethers (eg, monoste
  • the IOB value of the polar oil (A) may be preferably 0.1 or more and 0.5 or less, more preferably 0.1 or more and 0.4 or less, regardless of the presence or absence of the ultraviolet absorbing function.
  • the IOB value of the ultraviolet absorbing polar oil is preferably 0.1 or more and 0.3 or less.
  • the IOB value of the polar oil having no ultraviolet absorbing function, particularly the ester oil is preferably 0.05 or more and 0.8 or less.
  • the "inorganic value” and “organic value” are various atoms such as 20 for one carbon atom in the molecule and 100 for one hydroxyl group. It is determined according to the functional group.
  • the IOB value of the compound can be calculated (for example, by Fujita, "Chemical Area”). Volume 11, No. 10, pp. 719-725, 1957).
  • the content of the polar oil (A) is preferably more than 10% by mass, 15% by mass or more, more preferably 19% by mass or more, still more preferably 20% by mass or more, still more preferably 20% by mass or more, based on the total amount of the sunscreen composition. It may be 25% by mass or more.
  • the content of the polar oil (A) may be preferably 50% by mass or less, more preferably 45% by mass or less, still more preferably 40% by mass or less, based on the total amount of the sunscreen composition.
  • the content of the ultraviolet absorbing polar oil in the polar oil (A) is preferably 10% by mass or more, more preferably 20% by mass or more, still more preferably 30% by mass or more, based on the total amount of the (A) polar oil. It may be there.
  • the content of the ultraviolet absorbing polar oil with respect to the total amount of the polar oil (A) is not particularly limited, but may be preferably 70% by mass or less, more preferably 60% by mass or less, and further preferably 50% by mass or less.
  • the content of the ultraviolet absorbing polar oil may be preferably 3% by mass or more, more preferably 5% by mass or more, based on the total amount of the sunscreen composition.
  • the content of the ultraviolet absorbing polar oil may be preferably 35% by mass or less, more preferably 25% by mass or less, based on the total amount of the sunscreen composition.
  • the ultraviolet absorbing function of the sunscreen composition can be enhanced.
  • the content of the ultraviolet absorbing polar oil is 35% by mass or less, good solubility of the ultraviolet absorbing polar oil in the sunscreen composition can be maintained.
  • the content of the polar oil (A) may be preferably 10% by mass or more and 90% by mass or less, more preferably 20% by mass or more and 80% by mass or less, based on the total amount of the oily components in the sunscreen composition. ..
  • the total amount of the oily component in the sunscreen composition may be preferably 20% by mass or more and 80% by mass or less, more preferably 30% by mass or more and 70% by mass or less, based on the total amount of the sunscreen composition.
  • the silicone oil may be a volatile oil or a non-volatile oil. Further, the silicone oil (B) preferably has a viscosity at 25 ° C. of 1 mPa ⁇ s or more and 500 mPa ⁇ s or less, and more preferably 1 mPa ⁇ s or more and 100 mPa ⁇ s or less.
  • silicone oil (B) examples include chain polysiloxanes such as dimethylpolysiloxane (dimethicone), methylphenylpolysiloxane, and diphenylpolysiloxane; octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, and dodecamethylcyclohexasiloxane.
  • chain polysiloxanes such as dimethylpolysiloxane (dimethicone), methylphenylpolysiloxane, and diphenylpolysiloxane
  • octamethylcyclotetrasiloxane decamethylcyclopentasiloxane
  • dodecamethylcyclohexasiloxane examples include chain polysiloxanes such as dimethylpolysiloxane (dimethicone), methylphenylpolysiloxane, and diphenylpolysiloxane;
  • Cyclic polysiloxanes such as; silicone resins forming a three-dimensional network structure; silicone rubbers; modified polysiloxanes such as amino-modified polysiloxanes, polyether-modified polysiloxanes, alkyl-modified polysiloxanes, and fluorine-modified polysiloxanes; and acrylic silicones. And so on.
  • modified polysiloxanes such as amino-modified polysiloxanes, polyether-modified polysiloxanes, alkyl-modified polysiloxanes, and fluorine-modified polysiloxanes
  • acrylic silicones and so on.
  • chain polyloxane since a good tactile sensation of the sunscreen composition can be obtained by blending, it is preferable to use chain polyloxane, and it is more preferable to use dimethylpolysiloxane.
  • the composition according to this embodiment contains substantially no cyclic polysiloxane or no cyclic polysiloxane in consideration of the environment.
  • cyclotetrasiloxane, cyclopentasiloxane, and cyclohexasiloxane are substantially free or completely free.
  • the content of (B) silicone oil is preferably selected according to the content of (A) polar oil.
  • the value of the ratio of the content of (B) silicone oil to the content of (A) polar oil ([(B) content of silicone oil] / [(content of (A) polar oil]) is 0.01 or more. It may be 0.75 or less, preferably 0.01 or more and 0.65 or less, more preferably 0.02 or more and 0.55 or less, still more preferably 0.02 or more and 0.45 or less, still more preferably 0.02. It may be 0.35 or more, more preferably 0.03 or more and 0.25 or less.
  • the dispersibility of each component can be improved. Improves, which improves the UV protection of the sunscreen composition.
  • the content of (B) silicone oil is preferably 0.1% by mass or more and less than 20% by mass, more preferably 0.5% by mass or more and 15% by mass or less, more preferably, based on the total amount of the sunscreen composition. May be 0.7% by mass or more and 13% by mass or less, more preferably 1% by mass or more and 10% by mass or less.
  • the dispersibility of each component particularly the dispersibility of the ultraviolet absorber, the ultraviolet scattering agent, or both, is improved, and thereby the ultraviolet protective action of the sunscreen composition. Is improved.
  • the (C) inorganic fine powder in this embodiment is a fine powder having an average particle size of primary particles of 100 nm or less.
  • the average particle size may be the average diameter (median diameter) of the major axis based on the image taken by a transmission electron microscope (TEM).
  • Inorganic fine powder is not particularly limited, and titanium oxide, zinc oxide, talc, silica, mica, sericite, kaolin, mica, black iron oxide, yellow iron oxide, red iron oxide, ultramarine, dark blue, chromium oxide, hydroxylated.
  • the inorganic powder may be a composite powder in which particles other than titanium oxide, such as mica titanium, are coated with titanium oxide. These inorganic powders may be used alone or in combination of two or more.
  • the inorganic fine powder may be an inorganic fine powder having an ultraviolet scattering function, that is, an ultraviolet scattering agent.
  • an ultraviolet scattering agent As the (C) inorganic fine powder having an ultraviolet scattering function, one or more of titanium oxide and zinc oxide can be preferably used from the viewpoint of high ultraviolet scattering function and easy handling, particularly titanium oxide and zinc oxide. It is preferable to use zinc oxide in combination.
  • the particle surface of the (C) inorganic fine powder may be hydrophobized.
  • (C) the inorganic fine powder can be satisfactorily dispersed in the oil phase.
  • Hydrophobicization of the inorganic fine powder can be obtained by introducing a hydrophobic group onto the particle surface of the inorganic fine powder or by a hydrophobizing treatment for forming a coating of a hydrophobic substance.
  • the hydrophobic treatment may be a wet method using a solvent, a vapor phase method, a mechanochemical method or the like.
  • silicones such as methylhydrogenpolysiloxane, dimethylpolysiloxane, triethoxycaprylylsilane, dextrin fatty acid ester, higher fatty acid, higher alcohol, fatty acid ester, metal soap, alkyl phosphate ether, etc.
  • a fluorine compound or a hydrocarbon such as squalane or paraffin can be used.
  • the content of the inorganic fine powder (C) is preferably 5% by mass or more and 60% by mass or less, more preferably 8% by mass or more and 30% by mass or less, still more preferably 8% by mass or more, based on the total amount of the sunscreen composition. It can be 25% by mass or less, more preferably 8% by mass or more and 22% by mass or less, and further preferably 8% by mass or more and 20% by mass or less.
  • the ultraviolet protection function of the (C) inorganic fine powder in the sunscreen composition can be improved.
  • the dispersibility of the (C) inorganic fine powder can be maintained well.
  • the hydrophobized (C) inorganic fine powder is dispersed in oily components such as silicone oil, ester oil, polar oil, hydrocarbon oil, higher fatty acid, and higher alcohol. It is preferable to obtain a dispersion and then mix it with other components. As a result, the dispersibility of the (C) inorganic fine powder can be improved, and the ultraviolet scattering function of the (C) inorganic fine powder can be satisfactorily exhibited in the sunscreen composition.
  • oily components such as silicone oil, ester oil, polar oil, hydrocarbon oil, higher fatty acid, and higher alcohol. It is preferable to obtain a dispersion and then mix it with other components. As a result, the dispersibility of the (C) inorganic fine powder can be improved, and the ultraviolet scattering function of the (C) inorganic fine powder can be satisfactorily exhibited in the sunscreen composition.
  • a gelling agent can be added in order to stabilize the dispersed state of the (C) inorganic fine powder.
  • the sunscreen composition according to this embodiment may contain an inorganic powder other than the above-mentioned (C) inorganic fine powder.
  • the sunscreen composition according to this embodiment may contain an inorganic powder having an average particle size of more than 100 nm.
  • the inorganic powder other than the (C) inorganic fine powder for example, it may be capable of imparting functions such as coloring and improving the aesthetics of the coated surface (giving gloss, covering uneven color).
  • Polyglycerin-modified silicone is a polymer compound having both a glycerin chain portion and a silicone chain portion. Since the glycerin chain portion can be well adsorbed to the inorganic powder, particularly the (C) inorganic fine powder having a small particle size, and the silicone chain portion can be well dissolved in the oily component, (D) poly By using glycerin-modified silicone, the inorganic powder can be well dispersed in the oil phase.
  • the polyglycerin-modified silicone may be a compound in which a polyglycerin side chain is introduced into a silicone main chain, or may be a block copolymer of a silicone chain and a polyglycerin chain (polyether group). ..
  • the (D) polyglycerin-modified silicone used in this embodiment is particularly preferably glycerin or polyglycerin having both ends modified with silicone (sometimes referred to as double-ended silicone-modified glycerin or both-ended silicone-modified polyglycerin). ..
  • the (D) polyglycerin-modified silicone may be both-terminal silicone-modified glycerin represented by the following structural formula (1), preferably structural formula (2).
  • R1 is a linear or branched alkyl group having 1 to 12 carbon atoms or a phenyl group
  • R2 is an alkyl group having 2 to 11 carbon atoms
  • m is 10 to 120
  • n is 1 to 11. be.
  • R1 is a linear or branched alkyl group having 1 to 12 carbon atoms, or a phenyl group, m is 10 to 120, and n is 1 to 11.
  • the hydrophilic lipophilic balance (HLB) of the polyglycerin-modified silicone is preferably 0.2 to 3.0.
  • the molecular weight of the (D) polyglycerin-modified silicone is preferably 2000 to 20000.
  • the (D) polyglycerin-modified silicone examples include polyglyceryl-3 disiloxane dimethicone, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, lauryl polyglyceryl-3 polydimethylsiloxyethyl dimethicone, bis-butyl dimethicone polyglyceryl-3, (dimethicone /).
  • examples thereof include polyglycerin-3) crosspolymer, (lauryldimethicone / polyglycerin-3) crosspolymer, and (polyglyceryl-3 / laurylpolydimethylsiloxyethyldimethicone) crosspolymer.
  • These (D) polyglycerin-modified silicones can be used alone or in combination of two or more.
  • Examples of commercially available products of the polyglycerin-modified silicone include KF-6100, KF-6104, KF-6105, KF-6106, and KF-6109 manufactured by Shin-Etsu Chemical Co., Ltd.
  • (D) polyglycerin-modified silicone used in this embodiment a non-crosslinked polyglycerin-modified silicone that does not constitute a cross polymer is preferable, and polyglyceryl-3 disiloxane dimethicone, polyglyceryl-3 polydimethylsiloxyethyl dimethicone, and lauryl polyglyceryl- 3 It is more preferable that it is one or more of polydimethylsiloxyethyl dimethicone and bisbutyldimethicone polyglyceryl-3.
  • (C) the function of dispersing the inorganic fine powder in the oil phase is particularly high, it is preferable to use 1 or more of polyglyceryl-3 polydimethylsiloxyethyl dimethicone and bisbutyldimethicone polyglyceryl-3, and bisbutyldimethicone polyglyceryl. It is more preferable to use -3.
  • the content of the polyglycerin-modified silicone (D) is preferably 0.05% by mass or more and 5% by mass or less, more preferably 0.1% by mass or more and 4% by mass or less, still more preferably, based on the total amount of the sunscreen composition. May be 0.5% by mass or more and 3% by mass or less.
  • (D) polyglycerin-modified silicone By setting the content of (D) polyglycerin-modified silicone to 0.05% by mass or more, (C) the dispersibility of the inorganic fine powder can be improved, and an excessive increase in viscosity can be prevented, thus improving the usability. Can be done.
  • the content is 5% by mass or less, the stability of the emulsified system of the sunscreen composition can be maintained satisfactorily.
  • the value of the ratio of the content of (D) polyglycerin-modified silicone to the content of (C) inorganic fine powder may be preferably 0.015 or more and 0.6 or less, and more preferably 0.03 or more and 0.5 or less.
  • the sunscreen composition according to this embodiment preferably contains (E) hydrocarbon oil in addition to the above-mentioned components (A) to (D).
  • the (E) hydrocarbon oil has high compatibility with (A) polar oil, and also has high compatibility with (B) silicone oil. Therefore, by adding (E) hydrocarbon oil, (A) polar oil and (B) silicone oil can be mixed well in the sunscreen composition according to this embodiment. Further, by adding (E) hydrocarbon oil, the dispersibility of (C) inorganic fine powder can be improved.
  • (E) hydrocarbon oil examples include isododecane, isohexadecane, isoparaffin, liquid paraffin, ozokerite, squalene, pristane, paraffin, selecin, squalene, petrolatum, microcrystalline wax and the like.
  • These (E) hydrocarbon oils can be used alone or in combination of two or more.
  • isododecane because it has high compatibility with (A) polar oil and (B) silicone oil and can improve the tactile sensation of the obtained sunscreen composition.
  • the content of the hydrocarbon (E) is preferably 0.5% by mass or more and 30% by mass or less, more preferably 1% by mass or more and 20% by mass or less, still more preferably 5% by mass, based on the total amount of the sunscreen composition. It may be% or more and 15% by mass or less.
  • the sunscreen composition according to this embodiment may contain other optional components in addition to the above-mentioned components (A) to (E).
  • Other components include other oily components (ie, (A) polar oils, (B) silicone oils, and (E) oily components other than hydrocarbon oils), aqueous components, oil gelling agents, surfactants, chelates. Agents, thickeners and the like can be mentioned. These components can be added in an amount that does not interfere with the effect of improving the stability of the dosage form of the composition obtained by the present embodiment.
  • oily components are not particularly limited, and can be oily components usually used in external compositions such as cosmetics and quasi-drugs.
  • oily components other than polar oils include waxes, fragrances and the like.
  • the aqueous component is not particularly limited as long as it is an aqueous component usually used in external compositions such as cosmetics and quasi-drugs.
  • aqueous component water, a water-soluble alcohol, a thickener, a moisturizer, a chelating agent, a preservative, a pigment and the like can be used.
  • purified water As water, purified water, ion-exchanged water, tap water, etc. can be used.
  • water-soluble alcohol examples include lower alcohols, polyhydric alcohols, polyhydric alcohol polymers, alcohol alkyl ethers, alcohol ether esters, glycerin monoalkyl ethers, sugar alcohols, monosaccharides, oligosaccharides, polysaccharides and derivatives thereof. Can be mentioned.
  • Examples of the lower alcohol include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.
  • Polyhydric alcohols include dihydric alcohols (eg, dipropylene glycol, 1,3-butylene glycol, ethylene glycol, trimethylene glycol, 1,2-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene).
  • dihydric alcohols eg, dipropylene glycol, 1,3-butylene glycol, ethylene glycol, trimethylene glycol, 1,2-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene.
  • Trihydric alcohol eg, glycerin, trimethylolpropane, etc.
  • tetrahydric alcohol diglycerin, 1,2,6-hexane, etc.
  • pentaerythritol such as triol
  • pentahydric alcohols xylitol, triglycerin, etc.
  • hexahydric alcohols eg, sorbitol, mannitol, etc.
  • oil gelling agents examples include dextrin fatty acid esters such as dextrin palmitate, dextrin oleate, dextrin stearate, dextrin myristin, and (palmitic acid / 2-ethylhexanoic acid) dextrin; sucrose caprylic acid ester, sucrose caprin.
  • dextrin fatty acid esters such as dextrin palmitate, dextrin oleate, dextrin stearate, dextrin myristin, and (palmitic acid / 2-ethylhexanoic acid) dextrin
  • sucrose caprylic acid ester sucrose caprin.
  • Sucrose fatty acid esters such as acid esters, sucrose lauric acid esters, sucrose myristic acid esters, sucrose palmitate esters, sucrose stearate esters, sucrose oleic acid esters, sucrose erucic acid esters; Glyceryl fatty acid esters such as isostearic acid / eicosandioic acid) glyceryl, (bechenic acid / eicosandiic acid) glyceryl, (bechenic acid / eicosandioic acid) polyglyceryl-10; and salts or derivatives thereof.
  • the oil gelling agent may be an organically modified clay mineral such as disteardimonium hectorite, dimethylalkylammonium hectorite, and benzyldimethylstearylammonium hectorite.
  • the surfactant may be a cationic surfactant, an anionic surfactant, a nonionic surfactant, an amphoteric surfactant, or the like. Of these, it is preferable to use a nonionic surfactant.
  • the surfactant component can act as an emulsifier and improve the stability of the emulsion system in the dosage form.
  • the nonionic surfactant is not particularly limited as long as it is a nonionic surfactant usually used for external preparations such as cosmetics and quasi-drugs.
  • Specific examples of the nonionic surfactant include polyoxyethylene hydrogenated castor oil such as PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil, and PEG-100 hydrogenated castor oil.
  • Polyoxyethylene / methylpolysiloxane copolymers such as PEG-3 dimethicone, PEG-9 dimethicone, PEG10-dimethicone, PEG12-dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone; polyglyceryl-2 diisostearate, polyglyceryl triisostearate Polyglycerin fatty acid ester such as -2; monoglycerin fatty acid ester such as glyceryl stearate and glyceryl oleate; polyoxyethylene sorbitan sorbitan fatty acid ester such as polyoxyethylene sorbitan monooleate and polyoxyethylene sorbitan monostearate; sesquioleic acid Examples thereof include sorbitan fatty acid esters such as sorbitan, sorbitan sesquiisostearate, sorbitan isostearate, and sorbitan palmitate; and self-emulsifying propylene glycol
  • the content of the surfactant is preferably 0.5% by mass or more and 8% by mass or less, and more preferably 1% by mass or more and 5% by mass or less, based on the total amount of the sunscreen composition.
  • thickener examples include plant-based polymers (eg, arabic gum, tragant gum, galactan, guagam, carrageenan, etc.), microbial-based polymers (eg, xanthan gum, dextran, succinoglycan, purulan, etc.), and animal-based polymers (eg, xanthan gum, dextran, succinoglycan, purulan, etc.).
  • plant-based polymers eg, arabic gum, tragant gum, galactan, guagam, carrageenan, etc.
  • microbial-based polymers eg, xanthan gum, dextran, succinoglycan, purulan, etc.
  • animal-based polymers eg, xanthan gum, dextran, succinoglycan, purulan, etc.
  • collagen, casein, albumin, gelatin, etc. starch-based polymers (for example, carboxymethyl starch, methylhydroxypropyl starch, etc.),
  • antioxidants include antioxidants, preservatives, anti-inflammatory agents, whitening agents, plant extracts, activators, blood circulation promoters, anti-seborrheic agents and the like. These components can also be added in an amount that does not interfere with the UV protection action of the sunscreen composition according to the present embodiment and does not impair the usability of the sunscreen composition.
  • composition according to this embodiment may contain an organic powder containing a resin powder such as polyamide or polyethylene, but it is preferable that the composition does not substantially contain such an organic powder. It is more preferable that it is not contained at all.
  • the dosage form of the sunscreen composition obtained by this embodiment may be a water-in-oil type or an oil-in-water type, but a water-in-oil type is preferable.
  • the sunscreen composition according to this embodiment may be a sunscreen for the body or face (sunscreen), or a cosmetic having a high sunscreen effect (for example, a basic cosmetic such as foundation or base makeup). , Makeup cosmetics, etc.).
  • the viscosity of the sunscreen composition obtained by this embodiment may be preferably 100 mPa ⁇ s or more and 100,000 mPa ⁇ s or less, and more preferably 1,000 mPa ⁇ s or more and 40,000 mPa ⁇ s or less.
  • the viscosity is in the above range, a good feeling of use can be obtained, and the sunscreen composition can be applied on the skin at a uniform thickness to some extent at the time of use, so that a high UV protection function can be obtained. Obtainable.
  • the components shown in Table 1 were mixed by a conventional method to prepare and evaluate the compositions of Examples 1 to 5 and Comparative Examples 1 to 4. At the time of mixing, the mixtures of (I) to (IV) shown in Table 1 were prepared in advance, and they were mixed to obtain a composition.
  • the obtained composition was evaluated as follows.
  • the sunscreen composition of each example was added dropwise to a measurement plate (S plate; 5 ⁇ 5 cm V-groove PMMA plate, SPFMASTER-PA01) at an amount of 2 mg / cm 2, applied with a finger for 60 seconds, and dried for 15 minutes.
  • the absorbance was measured with a U-3500 self-recording spectrophotometer manufactured by Hitachi, Ltd.
  • the absorbance (Abs) was calculated by the following formula using glycerin having no ultraviolet absorption as a control.
  • T the transmittance of the sample
  • To the transmittance of glycerin
  • the absorbance was measured in the wavelength range of 280 to 400 nm, and the peak top and the integrated value (area integrated value) were determined. Table 1 shows the results of the integrated values of each example.
  • FIG. 1 shows the relationship between the value of the ratio of the content of the silicone oil to the content of the polar oil and the integrated amount of the intensity of the absorbance (Examples 1, 4 and 5 and Comparative Examples 1 and 2).
  • Example 1 Compared Examples 1 to 3 in which different types of dispersants ((D) polyglycerin-modified silicone) were blended in the same amount, the absorbance of Example 1 containing bisbutyldimethicone polyglyceryl-3 was found. It turned out to be the highest. It was also found that the absorbance of Comparative Example 4 containing the same amount of isostearic acid instead of (D) polyglycerin-modified silicone was inferior to that of Examples 1 to 3.
  • Examples 1, 4 and 5 and Comparative Examples 2 and 3 containing the same type and the same amount of dispersant ((D) polyglycerin-modified silicone) and an ultraviolet absorber but different in the content of dimethicone (silicone oil) are compared. In this case, it was found that the absorbance decreased as the amount of dimethicone increased. On the other hand, it was found that Comparative Example 1 containing no silicone oil also had a small absorbance and a small UV protection effect.

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Abstract

L'invention concerne une composition d'écran solaire comprenant (A) une huile polaire, (B) une huile de silicone, (C) une poudre fine inorganique et (D) une silicone modifiée par polyglycérine, le rapport de la teneur en huile de silicone (B) sur la teneur en huile polaire (A) étant de 0,01 à 0,75 inclus.
PCT/JP2021/002968 2020-01-31 2021-01-28 Composition d'écran solaire WO2021153651A1 (fr)

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
WO2022185977A1 (fr) * 2021-03-03 2022-09-09 株式会社資生堂 Composition mixte huile-eau

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007008916A (ja) * 2005-06-01 2007-01-18 Shiseido Co Ltd 油中水型皮膚外用組成物
JP2007145722A (ja) * 2005-11-24 2007-06-14 Shiseido Co Ltd 日焼け止め化粧料
JP2010159229A (ja) * 2009-01-08 2010-07-22 Tokiwa Corp 油中水型日焼け止め化粧料
JP2010222349A (ja) * 2009-02-27 2010-10-07 Shiseido Co Ltd 日焼け止め化粧料
WO2016068298A1 (fr) * 2014-10-31 2016-05-06 株式会社 資生堂 Produit cosmétique de protection solaire sous forme d'émulsion eau-dans-huile
JP2018076283A (ja) * 2016-11-02 2018-05-17 ロート製薬株式会社 有機紫外線吸収剤の光耐久性向上剤
JP2020007379A (ja) * 2016-03-02 2020-01-16 株式会社ファンケル 油中水型乳化化粧料

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007008916A (ja) * 2005-06-01 2007-01-18 Shiseido Co Ltd 油中水型皮膚外用組成物
JP2007145722A (ja) * 2005-11-24 2007-06-14 Shiseido Co Ltd 日焼け止め化粧料
JP2010159229A (ja) * 2009-01-08 2010-07-22 Tokiwa Corp 油中水型日焼け止め化粧料
JP2010222349A (ja) * 2009-02-27 2010-10-07 Shiseido Co Ltd 日焼け止め化粧料
WO2016068298A1 (fr) * 2014-10-31 2016-05-06 株式会社 資生堂 Produit cosmétique de protection solaire sous forme d'émulsion eau-dans-huile
JP2020007379A (ja) * 2016-03-02 2020-01-16 株式会社ファンケル 油中水型乳化化粧料
JP2018076283A (ja) * 2016-11-02 2018-05-17 ロート製薬株式会社 有機紫外線吸収剤の光耐久性向上剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022185977A1 (fr) * 2021-03-03 2022-09-09 株式会社資生堂 Composition mixte huile-eau

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