WO2021143042A1 - 一种治疗重度烧伤及皮肤坏疽的药物组合物及其应用 - Google Patents

一种治疗重度烧伤及皮肤坏疽的药物组合物及其应用 Download PDF

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WO2021143042A1
WO2021143042A1 PCT/CN2020/096298 CN2020096298W WO2021143042A1 WO 2021143042 A1 WO2021143042 A1 WO 2021143042A1 CN 2020096298 W CN2020096298 W CN 2020096298W WO 2021143042 A1 WO2021143042 A1 WO 2021143042A1
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parts
skin
servings
raw materials
traditional chinese
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PCT/CN2020/096298
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English (en)
French (fr)
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陈伟
万美蓉
高云
杨若霖
时晰
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北京光捷扬基健康科技有限公司
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    • A61K35/56—Materials from animals other than mammals
    • A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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Definitions

  • the present invention relates to the field of medicine, in particular, to a pharmaceutical composition for treating severe burns and skin gangrene and its application.
  • Burns refer to heat, including skin and/or mucous membranes, even muscles, bones, and joints caused by hydrothermal fluid (water, soup, oil, etc.), steam, high-temperature gas, flame, hot metal liquid or solid (such as molten steel, steel ingot), etc. Even internal organs are damaged. Scald is a kind of tissue damage caused by hot liquid, steam, etc., which is a kind of thermal burn.
  • Deep burns refer to burns that require more than 21 days for the wound to heal on its own. Including deep second-degree burns, third-degree burns, and fourth-degree burns with infection, which usually require surgical treatment.
  • the epidermis of deep second-degree burns is whitish or brownish-yellow. After removing the necrotic skin, the wound surface is slightly wet or red and white, and the sensation is dull. There are red spots of millet size. It usually takes 3 to 4 weeks to heal.
  • the local manifestations of third-degree burns may be Pale, yellow-brown, brown, and severe cases are scorched or charred, the skin loses elasticity, it is as hard as leather, it is dry and non-exudative, and it feels poor. It requires surgical skin grafting, and there will be scars after healing.
  • Gangrene refers to special morphological changes such as black and dark green after tissue necrosis due to secondary spoilage infection and other factors.
  • Gangrene is divided into dry gangrene and wet gangrene, and wet gangrene includes gas gangrene.
  • Dry gangrene is mostly seen in the extremities, such as atherosclerosis, thromboangiitis obliterans and other diseases.
  • the arteries are blocked and the veins return smoothly, so the water content of the necrotic tissue is low, and the water on the body surface is easy to evaporate, causing the lesion to dry and shrink and appear dark brown (the necrotic tissue is decomposed by spoilage bacteria to produce hydrogen sulfide, which interacts with hemoglobin.
  • the iron that is decomposed in it combines to form iron sulfide, which makes the necrotic tissue appear black), and there is a clear boundary between it and the surrounding healthy tissue. Because the necrotic tissue is relatively dry, the spoilage bacteria infection is generally mild.
  • necrotic tissue contains more water, the spoilage bacteria infection is serious, the local area is obviously swollen, and it is blue-green.
  • the putrefaction bacteria decompose protein, produce indole, skatole, etc., causing bad odor. Due to the rapid development of lesions and diffuse inflammation, there is no obvious dividing line between necrotic tissue and healthy tissue.
  • Common wet gangrene includes gangrenous appendicitis, intestinal gangrene, pulmonary gangrene and postpartum gangrenous endometritis.
  • Gas gangrene is also a wet gangrene, which is caused by anaerobic bacteria such as Perfringens perfringens infecting deeper tissues. It develops quickly and has serious consequences. In addition to necrosis, it also produces a large amount of gas, causing the necrotic area to be twisted. feel. The incubation period is 6 hours to 6 days. The clinical symptoms are severe pain like swelling and cracking, the wound begins to be red and swollen, the skin is pale, and the skin is tense and shiny. Subsequently, the skin of the wound turned purple-black, blisters of dark red liquid appeared, and foul-smelling liquid could flow out. The muscles in the wound are dark red and swollen, lose their elasticity, and the knife does not contract or bleed. Systemic symptoms including sepsis appear later.
  • the present invention provides a pharmaceutical composition for treating severe burns and skin gangrene, which can quickly heal severe burns.
  • the invention also provides a medicine based on the medicine composition and a preparation method.
  • the invention develops a traditional Chinese medicine formula capable of effectively resisting infection, promoting skin growth, and activating the tendons and collaterals to treat severe burns and skin gangrene.
  • the technology of the present invention is as follows:
  • composition A The pharmaceutical composition for treating severe burns and skin gangrene of the present invention includes composition A and composition B, wherein:
  • the pharmaceutical composition A includes the following traditional Chinese medicine raw materials:
  • the pharmaceutical composition B includes the following traditional Chinese medicine raw materials:
  • 15-25 parts of wild chrysanthemum 15-25 parts of Aesculus vulgaris, 15-25 parts of Xu Changqing, 15-25 parts of gentian, 15-25 parts of Bupleurum, 15-25 parts of scutellaria, 15-25 parts of ghost and arrow feather , Alisma 15-25 parts, Dilong 15-25 parts, Mutong 15-25 parts, Plantain 15-25 parts, Atractylodes 15-25 parts, Tangerine peel 15-25 parts, Wild chrysanthemum 15-25 parts, Dandelion 15-25 servings.
  • the invention also provides the application of the above-mentioned pharmaceutical composition in the preparation of a medicine for treating severe burns and skin gangrene.
  • the present invention also provides a pharmaceutical preparation for treating severe burns and skin gangrene.
  • the pharmaceutical preparation includes the above-mentioned Chinese medicine composition.
  • the pharmaceutical preparations of the present invention include external spray A and internal powder B;
  • the external spray A includes the following Chinese medicine raw materials:
  • the oral powder B includes the following traditional Chinese medicine raw materials:
  • 15-25 parts of wild chrysanthemum 15-25 parts of Aesculus vulgaris, 15-25 parts of Xu Changqing, 15-25 parts of gentian, 15-25 parts of Bupleurum, 15-25 parts of scutellaria, 15-25 parts of ghost and arrow feather , Alisma 15-25 parts, Dilong 15-25 parts, Mutong 15-25 parts, Plantain 15-25 parts, Atractylodes 15-25 parts, Tangerine peel 15-25 parts, Wild chrysanthemum 15-25 parts, Dandelion 15-25 servings.
  • the external spray A includes the following traditional Chinese medicine materials: 20 parts of honeysuckle, 20 parts of Isatis root, 20 parts of toad skin, 20 parts of rhubarb, 20 parts of angelica, bitter 20 copies of Ginseng, 20 copies of White Moss Bark, 20 copies of Gongying, 20 copies of Wang Buliu Xing, 10 copies of Indigo Naturalis;
  • the oral powder B includes the following raw materials of Chinese medicine: 20 parts of wild chrysanthemum, 20 parts of Aesculus vulgaris, 20 parts of Xu Changqing, 20 parts of Gentian, 20 parts of Bupleurum, 20 parts of Scutellaria baicalensis, 20 parts of Ghost Arrow Feather, 20 parts of Alisma orientalis Parts, 20 parts of Dilong, 20 parts of Plantago Seed, 20 parts of Atractylodes macrocephala, 20 parts of dried tangerine peel, 20 parts of wild chrysanthemum, 20 parts of dandelion.
  • the present invention also provides a method for preparing any one of the above-mentioned pharmaceutical preparations, including the following steps:
  • the external spray A is to soak the raw materials of traditional Chinese medicine (refer to the conventional operation in the field for the specific soaking time) and then boil for 20-30 minutes, and then continue to decoct for 1-3 hours. After the decoction, the residue is removed and the liquid medicine is left (or The raw materials of traditional Chinese medicine are brewed with 40-65° white wine for more than one month, then the residue is removed and the liquid is left);
  • the powder B for oral administration is pulverized and ground through a 60-200 mesh sieve.
  • topical spray A three times a day, 10 mL each time
  • internal powder B three times a day, 20 g each time.
  • Gentian grass relieves the heat of the Jueyin and Liver Meridian of the foot, Chaihu clears the heat of the Shaoyang Meridian of the foot, Scutellaria baicalensis clears the lungs and the heat of the Triple Burner, Alisma orientalis, Mutong, and Psyllium purify the small intestine, and the wet bladder comes out of urine, so it gets wet. Heat up.
  • the combination of these bitter and cold medicines can easily damage the spleen and stomach, but also reduce dryness and yin. Therefore, adding licorice to reconcile the nature of bitter and cold, and angelica nourishes blood and nourishes the liver.
  • the liver and gallbladder meridian has real fire, damp heat and pain in the hypochondrium. Deafness, ear swelling, poor urine color, urethral pain, swelling and itching, etc. can be eliminated by this prescription. Wild chrysanthemum and dandelion can enhance detoxification and swelling. Aesculus and Xu Changqing can clear away heat and detoxify and cool the liver.
  • Atractylodes macrocephala invigorating the spleen and drying dampness, tangerine peel, regulating qi and helping the movement and transformation of water and dampness, ghosts and arrows feathers, Yanhu, removing blood stasis and relieving pain, rhubarb to clear away heat and blood stasis, and has the beauty of axe, in short
  • the taste of bitter and cold is used to break its heat to prevent it from escaping and deepening or spreading, qi and blood stagnation, meridian blocking, and pain if it is blocked.
  • the prescription re-uses the ghost arrow feathers that promote blood circulation and break blood stasis, rhubarb, relieves meridians, and clears away heat. , Promote qi and blood dredging, and relieve pain.
  • the essence of the whole prescription is to take the meaning of "combating its heat, fighting poison with poison, expelling the basic evil, and restoring its righteousness". It has the meaning of extinguishing the fire when the virus is not congregating, and following the "external governance is the same as According to the principle that internal and external medicines are also internal medicines, according to the principle of treating different diseases at the same time in Chinese medicine, satisfactory results have been achieved in clinical application.
  • the improved medicament of the present invention has strong broad-spectrum bactericidal power, removes heat and clears away heat, detoxifies, cools the liver and calms convulsions, promotes blood circulation and breaks blood stasis, relaxes meridians, has strong penetrating power, and controls infection It has a good effect, protects injured and uninjured tissues, reduces the chance of infection, accelerates tissue repair, shortens the treatment time, and generally has no scars after healing, no sequelae, short course of disease, 3-10 days recovery, average 6.5 days, low treatment cost, It reduces the economic burden of patients, reduces the unbearable pain, and has received satisfactory clinical results.
  • Fig. 1 is a schematic diagram of the experimental group in Example 4 of the present invention
  • Fig. A shows a scald area of 9*10cm
  • Fig. B shows the surgical removal of dead skin on the second day, and a wound area of 10*14cm
  • Fig. C shows a wound infection 10 days after the operation
  • D shows the wound area enlarged to 11*15cm due to infection at 17 days
  • Figure E shows the wound area is 9*10cm due to heavy infection and treated with the Chinese medicine spray and powder of the present invention
  • Figure F shows the wound at 7 days of treatment The area is 5*11cm
  • Figure G shows the wound area of 3*6cm (11 days), after which the medication is stopped
  • Figure H shows the wound area of 1*2.5cm (25 days).
  • Figure 2 is a schematic diagram of the control group in Example 4 of the present invention.
  • Figure A shows a burn area of 12*13 cm
  • Figure B shows the 5th day after surgical removal of dead skin
  • Figures C and D show death 10 days after surgery.
  • Figure 3 is a schematic diagram of the drug of the present invention used to treat skin gangrene, in the figure, A is before treatment, and B is 15 days after treatment.
  • a medicine for treating severe burns and skin gangrene comprising topical spray A and oral powder B; in parts by weight, said topical spray A includes the following traditional Chinese medicine raw materials: honeysuckle 20g, isatis root 20g, toad skin 20g, rhubarb 20g , Angelica 20g, Sophora flavescens 20g, White moss bark 20g, Gong Ying 20g, Wang Buliu line 20g, Indigo Naturalis 10g;
  • the oral powder B includes the following traditional Chinese medicine materials: 20g wild chrysanthemum, 20g Aesculus aesculus 20g, 20g Xu Changqing, 20g gentian, 20g Bupleurum, 20g scutellaria, 20g ghost arrow feather 20g, Alisma orientalis 20g, earthworm 20g, Mutong 20g, Plantago Seed 20g, Atractylodes Macrocephala 20g, Tangerine Peel 20g, Wild Chrysanthemum 20g, Dandelion 20g;
  • Powder B is obtained by pulverizing the above-mentioned medicine and sieving through 80 mesh.
  • a medicine for treating severe burns and skin gangrene comprising topical spray A and oral powder B; by weight, the topical spray A includes the following Chinese medicine raw materials: honeysuckle 15g, isatis root 15g, toad skin 15g, rhubarb 15g , Angelica 15g, Sophora flavescens 15g, White moss bark 15g, Gongying 15g, Wangbuliuxing 15g, Indigo Naturalis 5g;
  • the oral powder B includes the following raw materials of traditional Chinese medicine: 15g wild chrysanthemum, 15g aesculus aesculus 15g, 15g Xu Changqing, 15g gentian, 15g Bupleurum, 15g scutellaria, 15g ghost arrow feather, 15g Alisma, 15g earthworm, Mutong 15g, Plantago Seed 15g, Atractylodes macrocephala 15g, Tangerine Peel 15g, Wild Chrysanthemum 15g, Dandelion 15g;
  • Powder B is obtained by pulverizing the above-mentioned drug and sieving through a 60-mesh sieve.
  • a medicine for treating severe burns and skin gangrene comprising topical spray A and oral powder B; by weight, the topical spray A includes the following Chinese medicine raw materials: honeysuckle 25g, isatis root 25g, toad skin 25g, rhubarb 25g , Angelica 25g, Sophora flavescens 25g, White moss bark 25g, Gong Ying 25g, Wang Buliu Xing 25g, Indigo Naturalis 15g;
  • the oral powder B includes the following raw materials of traditional Chinese medicine: 25g wild chrysanthemum, 25g Aesculus aesculus 25g, 25g Xu Changqing, 25g gentian, 25g Bupleurum, 25g scutellaria, 25g ghost arrow feather, 25g Alisma, 25g earthworm, Mutong 25g, Plantago Seed 25g, Baizhu 25g, Tangerine Peel 25g, Wild Chrysanthemum 25g, Dandelion 25g;
  • the powder B is obtained by pulverizing the above-mentioned medicine through a 200-mesh sieve.
  • Example 1 The medicine prepared in Example 1 was used for the animal pig skin scald model test. When taking the medicine, follow the topical spray A, three times a day, 10mL each time; oral powder B, three times a day, 20g each time.
  • the burn area is 9*10cm
  • Figure B is the second day of surgery to remove dead skin
  • the wound area is 10*14cm
  • C is the wound infection 10 days after the operation
  • D is the wound area expanded to 11*15cm due to infection on the 17th day
  • E The wound area is 9*10cm when the infection is too heavy, using the Chinese medicine spray and powder of the present invention, the wound area is 9*10cm
  • F is the wound area of 5*11cm when the treatment is 7 days
  • G the wound area is 3*6cm (11 days), After that, the medication was stopped
  • H wound area was 1*2.5cm (25 days).
  • Control group 114-day-old sow weighing 11.6kg, burned area of 12*13cm, soldering iron burn (deep third degree burn); operation started 3 days after the burn, wound area of 10*11cm, and died of infection 10 days after the operation ( Figure 2).
  • Example 1 of the present invention is administered as external spray A, three times a day, 10 mL each time; powder B is internally taken three times a day, 20 g each time.
  • Figure 3 a schematic diagram for the treatment of skin gangrene. After 15 days of treatment, the gangrene skin grows with new fleshy teeth and gradually removes the scabs, and it healed after 25 days of treatment ( Figure 3).
  • the invention can effectively achieve the effects of anti-infection, anti-inflammatory, activating blood circulation, promoting ischemic tissue regeneration, etc., and can effectively treat deep burns and gangrenous skin defects.
  • the burn treatment effect has been verified in a large animal pig model.
  • the legs of patients with gangrene have been validated for the treatment of clinical skin defects.
  • the overall effect is very satisfactory, meets expectations, and can meet the needs of large-scale promotion.

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Abstract

一种治疗重度烧伤及皮肤坏疽的药物组合物，由A剂和B剂组成，A喷剂包括：金银花15-25份，板蓝根15-25份，蟾蜍皮15-25份，大黄15-25份，当归15-25份，苦参15-25份，白鲜皮15-25份，蒲公英15-25份，王不留行15-25份，青黛5-15份；B粉剂包括：野菊花15-25份，七叶一枝花15-25份，徐长卿15-25份，龙胆草15-25份，柴胡15-25份，黄芩15-25份，鬼箭羽15-25份，泽泻15-25份，地龙15-25份，木通15-25份，车前子15-25份，白术15-25份，陈皮15-25份，野菊花15-25份，蒲公英15-25份。

Description

一种治疗重度烧伤及皮肤坏疽的药物组合物及其应用
相关申请的交叉参考
该申请要求2020年01月17日提交的中国专利申请号为202010052933.0的专利申请的优先权，该专利申请在此被完全引入作为参考。
技术领域
本发明涉及医药领域，具体地，涉及一种治疗重度烧伤及皮肤坏疽的药物组合物及其应用。
背景技术
烧伤指热力，包括热液(水、汤、油等)、蒸气、高温气体、火焰、炽热金属液体或固体(如钢水、钢锭)等所引起的皮肤和/或黏膜，乃至肌肉、骨、关节甚至内脏组织损害。烫伤是由热液、蒸气等所引起的组织损伤，是热力烧伤的一种。
深度烧伤指创面自行愈合需要21天以上的烧伤。包括较深或伴感染的深Ⅱ度烧伤、Ⅲ度烧伤和Ⅳ度烧伤，通常需要手术治疗。深Ⅱ度烧伤表皮发白或棕黄，去除坏死皮后，创面微湿或红白相间，感觉迟钝，可见粟粒大小的红色小点，一般需3～4周愈合，Ⅲ度烧伤局部表现可为苍白、黄褐色、焦黄，严重者呈焦灼状或炭化，皮肤失去弹性，触之硬如皮革，干燥无渗液，感觉差，需要手术植皮治疗，愈合后有瘢痕。
严重烧伤病人由于体表、体内防御屏障的破坏，机体免疫功能的下降，广泛坏死组织的存在和体外、体内菌群的侵袭等引起的全身感染，是威胁患者生命的重要原因。目前主要抗感染治疗依赖经验性应用抗生素，即根据烧伤感染常见病原菌和该时期的烧伤创面细菌的一般资料，并参考细菌耐药现状和根据细菌耐药机制，选用可能敏感的抗生素。
坏疽(gangrene)，是指组织坏死后因继发腐败菌感染和其他因素影响而呈现黑色、暗绿色等特殊形态改变。坏疽分为干性坏疽和湿性坏疽，而湿性坏疽又包含了气性坏疽。
干性坏疽大多见于四肢末端，如动脉粥样硬化、血栓闭塞性脉管炎等疾患时。此时动脉受阻而静脉回流通畅，故坏死组织水分含量少，再加上体表水分易于蒸发，致使病变部位干燥皱缩，呈黑褐色(坏死组织经腐败菌分解产生硫化氢，后 者与血红蛋白中分解出来的铁相结合形成硫化铁，使坏死组织呈黑色)，与周围健康组织之间有明显的分界线。由于坏死组织比较干燥，因此腐败菌感染一般较轻。
湿性坏疽多发生于与外界相通的内脏(肠、子宫、肺、阑尾、胆囊等)，也可见于四肢(伴有淤血水肿时)。此时由于坏死组织含水分较多，故腐败菌感染严重，局部明显肿胀，呈蓝绿色。腐败菌分解蛋白质，产生吲哚、粪臭素等，造成恶臭。由于病变发展较快，炎症比较弥漫，故坏死组织与健康组织间无明显分界线。同时组织坏死腐败所产生的毒性产物及细菌毒素被吸收后，可引起全身中毒症状，甚至可发生中毒性休克而死亡。常见的湿性坏疽有坏疽性阑尾炎、肠坏疽、肺坏疽及产后坏疽性子宫内膜炎等。
气性坏疽也属湿性坏疽，由产气荚膜杆菌等厌氧菌感染侵入较深的组织引起，发展很快而且后果严重，除发生坏死外还产生大量气体，使坏死区按之有捻发感。潜伏期6小时至6日，临床症状为胀裂样剧痛，伤口开始红肿，皮肤苍白，紧张发亮。随后创周皮肤转紫黑色，出现有暗红液体的水疱，并且可流出恶臭液体。创口内肌肉暗红肿胀，失去弹性，刀割不收缩亦不出血。后期出现包括脓毒症在内的全身症状。
与烧伤类似，一些气血不通导致坏疽并伴随感染，同样依赖抗感染及活血化瘀等治疗。中药是我国传承至今的瑰宝，许多草药都具有抗炎症抗感染及活血功效，现在亟需研发出具有显著治愈效果的治疗重度烧伤及皮肤坏疽的中药配方。
发明内容
针对上述现有技术存在的问题，本发明提供一种治疗重度烧伤及皮肤坏疽的药物组合物，能快速治愈重度烧伤。本发明还提供了基于该药物组合物的药物及制备方法。
本发明借助祖传中药配方，开发出一种能够有效抗感染、促进皮肤增长，通筋活络的治疗重度烧伤及皮肤坏疽的中药配方。
为了实现上述目的，本发明技术如下：
本发明的治疗重度烧伤及皮肤坏疽的药物组合物，包括组合物A和组合物B，其中，
按重量份计，所述药物组合物A包括以下中药原料：
金银花15-25份，板蓝根15-25份，蟾蜍皮15-25份，大黄15-25份，当归15-25份，苦参15-25份，白藓皮15-25份，公英15-25份，王不留行15-25份， 青黛5-15份；
按重量份计，所述药物组合物B包括以下中药原料：
野菊花15-25份，七叶一枝花15-25份，徐长卿15-25份，龙胆草15-25份，柴胡15-25份，黄芩15-25份，鬼箭羽15-25份，泽泻15-25份，地龙15-25份，木通15-25份，车前子15-25份，白术15-25份，陈皮15-25份，野菊花15-25份，蒲公英15-25份。
本发明还提供上述药物组合物在制备治疗重度烧伤及皮肤坏疽的药物中的应用。
本发明还提供了一种治疗重度烧伤及皮肤坏疽的药物制剂，所述药物制剂包括上述的中药组合物。
本发明所述的药物制剂包括外用喷剂A和内服粉剂B；
按重量份计，所述外用喷剂A包括以下中药原料：
金银花15-25份，板蓝根15-25份，蟾蜍皮15-25份，大黄15-25份，当归15-25份，苦参15-25份，白藓皮15-25份，公英15-25份，王不留行15-25份，青黛5-15份；
所述内服粉剂B包括以下中药原料：
野菊花15-25份，七叶一枝花15-25份，徐长卿15-25份，龙胆草15-25份，柴胡15-25份，黄芩15-25份，鬼箭羽15-25份，泽泻15-25份，地龙15-25份，木通15-25份，车前子15-25份，白术15-25份，陈皮15-25份，野菊花15-25份，蒲公英15-25份。
进一步优选的，本发明所述药物制剂中，按重量份计，所述外用喷剂A包括以下中药原料：金银花20份，板蓝根20份，蟾蜍皮20份，大黄20份，当归20份，苦参20份，白藓皮20份，公英20份，王不留行20份，青黛10份；
所述内服粉剂B包括以下中药原料：野菊花20份，七叶一枝花20份，徐长卿20份，龙胆草20份，柴胡20份，黄芩20份，鬼箭羽20份，泽泻20份，地龙20份，车前子20份，白术20份，陈皮20份，野菊花20份，蒲公英20份。
本发明还提供了上述任一所述药物制剂的制备方法，包括以下步骤：
所述外用喷剂A是将各中药原料浸泡(具体浸泡时间参照本领域常规操作即可)后煮沸20-30min，然后文火继续煎煮1-3小时，煎煮后去渣留药液(或将各中药原料用40-65°白酒泡制一月以上后去渣留药液)；
所述内服粉剂B是将各中药原料粉碎研磨后过60-200目筛。
另外，外用喷剂A，一日三次，每次10mL；内服粉剂B一日三次，每次20g。
龙胆草泻足厥阴肝经之热，柴胡清足少阳经之热，黄芩清肺与三焦之热，泽泻、木通、车前子泻小肠，膀胱之湿从小便出，于是湿去热清。但是这些苦寒药合在一起，既易伤脾胃，又会化燥伤阴，因此加甘草调和苦寒之性，当归养血补肝，所以对于肝胆经有实火湿热而致的胁痛口苦，耳聋耳肿，小便赤色不畅，尿道疼痛，以及阴肿阴痒等证，此方都能消除，野菊花，蒲公英有增强解毒消肿作用，七叶一枝花和徐长卿有清热解毒、凉肝定惊之功，白术，健脾燥湿，陈皮，理气和中以助水湿之运化，鬼箭羽，延胡，化瘀止痛，大黄清热破瘀，并有斧底抽薪之妙，总之先以苦寒之味直折其热，以防其窜延深入或扩散，气血凝滞，经络阻隔，不通则痛，故方药重用活血破瘀的鬼箭羽，大黄，舒通经络，清热之剂，促进气血疏通，通则不痛。全方精华在于取其“折伏其热势、以毒攻毒、驱逐基邪恶、还其之正气”之义，具有在病毒未结聚之际，火势方张之时即给予扑灭，遵循“外治同于内治、外治之药亦是内治之药”的原则，根据中医异病同治的法则，在临床上应用取得了满意的疗效。
经临床实践证明，改良后的本发明中药剂，具有较强的广谱杀菌力，湿去热清，解毒、凉肝定惊之功，活血破瘀，舒通经络，浸透力强，控制感染作用好，保护受伤和未受伤的组织减少感染机会，加速组织修复，使缩短治疗时间，而且愈后一般无瘢痕，无后遗症，病程短、3-10天痊愈，平均6.5天，治疗费用低，减轻了患者的经济负担，减轻了难以承受的痛苦，在临床上收到了满意的效果。
附图说明
图1为本发明实施例4中实验组的示意图；图A中烫伤面积9*10cm，图B为第二天手术去死皮，伤口面积10*14cm；图C为手术10天后伤口感染；图D为17天时因感染，伤口面积扩大为11*15cm；图E为因感染过重，使用本发明的中药喷剂和粉剂进行治疗，伤口面积为9*10cm；图F为治疗7天时，伤口面积为5*11cm；图G为伤口面积为3*6cm(11天)，之后停止用药；图H为伤口面积1*2.5cm(25天)。
图2为本发明实施例4中对照组的示意图；图A中烫伤面积12*13cm，图B为手术去死皮后第5天，图C、D为术后10天，死亡。
图3为本发明的药物用于治疗皮肤坏疽的示意图，图中A为治疗前，B为 治疗15天后。
具体实施方式
为使本发明的目的、技术方案和优点更加清楚明了，下面对本发明进行进一步详细说明。但是应该理解，此处所描述的具体实施例仅仅用以解释本发明，并不用于限制本发明的范围。
实施例1
一种治疗治疗重度烧伤及皮肤坏疽的药物，包括外用喷剂A和内服粉剂B；按重量份计，所述外用喷剂A包括以下中药原料：金银花20g，板蓝根20g，蟾蜍皮20g，大黄20g，当归20g，苦参20g，白藓皮20g，公英20g，王不留行20g，青黛10g；
以上药材，流水清洗，去杂质，去泥土，加水浸过药材，然后放置在不绣钢容器内，加自来水1000mL，浸泡2小时后煮沸30分钟，然后文火继续煎煮3小时，过滤除渣得喷剂A；
所述内服粉剂B包括以下中药原料：野菊花20g，七叶一枝花20g，徐长卿20g，龙胆草20g，柴胡20g，黄芩20g，鬼箭羽20g，泽泻20g，地龙20g，木通20g，车前子20g，白术20g，陈皮20g，野菊花20g，蒲公英20g；
将上述药物粉碎后过80目筛得粉剂B。
实施例2
一种治疗治疗重度烧伤及皮肤坏疽的药物，包括外用喷剂A和内服粉剂B；按重量份计，所述外用喷剂A包括以下中药原料：金银花15g，板蓝根15g，蟾蜍皮15g，大黄15g，当归15g，苦参15g，白藓皮15g，公英15g，王不留行15g，青黛5g；
以上药材，流水清洗，去杂质，去泥土，加水浸过药材，然后放置在不绣钢容器内，用500mL的65°粮食酒泡制一月后去渣用200目过滤得喷剂A；
所述内服粉剂B包括以下中药原料：野菊花15g，七叶一枝花15g，徐长卿15g，龙胆草15g，柴胡15g，黄芩15g，鬼箭羽15g，泽泻15g，地龙15g，木通15g，车前子15g，白术15g，陈皮15g，野菊花15g，蒲公英15g；
将上述药物粉碎后过60目筛得粉剂B。
实施例3
一种治疗治疗重度烧伤及皮肤坏疽的药物，包括外用喷剂A和内服粉剂B； 按重量份计，所述外用喷剂A包括以下中药原料：金银花25g，板蓝根25g，蟾蜍皮25g，大黄25g，当归25g，苦参25g，白藓皮25g，公英25g，王不留行25g，青黛15g；
以上药材，流水清洗，去杂质，去泥土，加水浸过药材，然后放置在不绣钢容器内，加自来水800mL，浸泡2小时后煮沸20分钟，然后文火继续煎煮1小时，过滤除渣得喷剂A；
所述内服粉剂B包括以下中药原料：野菊花25g，七叶一枝花25g，徐长卿25g，龙胆草25g，柴胡25g，黄芩25g，鬼箭羽25g，泽泻25g，地龙25g，木通25g，车前子25g，白术25g，陈皮25g，野菊花25g，蒲公英25g；
将上述药物粉碎后过200目筛得粉剂B。
实施例4
取实施例1制得药物进行动物猪皮肤烫伤模型试验。用药时，按照外用喷剂A，一日三次，每次10mL；内服粉剂B，一日三次，每次20g。
处理方式：
实验组：117天龄，体重10.0kg的公猪，烫伤面积9*10cm，烙铁烫伤(III度烫伤)，具体变化如图1所示；
图A中烫伤面积9*10cm，图B为第二天手术去死皮，伤口面积10*14cm；C为手术10天后伤口感染；D为17天时因感染，伤口面积扩大为11*15cm；E：因感染过重，使用本发明的中药喷剂和粉剂进行治疗，伤口面积为9*10cm；F为治疗7天时，伤口面积为5*11cm；G伤口面积为3*6cm(11天)，之后停止用药；H伤口面积1*2.5cm(25天)。
对照组：114天龄，体重11.6kg的母猪，烫伤面积12*13cm，烙铁烫伤(深III度烫伤)；烫伤3天后开始手术，伤口面积10*11cm，术后10天因感染死亡(图2)。
本发明实施例1中的药物，按照外用喷剂A，一日三次，每次10mL；内服粉剂B，一日三次，每次20g。如图3，用于治疗皮肤坏疽的示意图，治疗15天后，坏疽皮肤长新肉牙逐浙脱痂，用药25天后痊愈(图3)。
本发明能够有效实现抗感染，消炎，活血通络，促进缺血性组织再生等功效，能够有效治疗包括深度烧伤以及坏疽性皮肤缺损，并在大动物猪模型中进行了烧伤治疗效果验证，在坏疽病人腿部进行了临床皮肤缺损治疗的相关验证。总体效果非常理想，达到预期，能够满足进行大规模推广的需要。
最后所应说明的是，以上实施例仅用以说明本发明的技术方案而非限制。尽管参照实施例对本发明进行了详细说明，本领域的普通技术人员应该理解，对本发明的技术方案进行修改或者等同替换，都不脱离本发明技术方案的精神和范围，其均应涵盖在本发明的权利要求范围当中。

Claims (6)

  1. 一种治疗重度烧伤及皮肤坏疽的药物组合物，其特征在于，所述药物组合物包括组合物A和组合物B，
    按重量份计，所述药物组合物A包括以下中药原料：
    金银花15-25份，板蓝根15-25份，蟾蜍皮15-25份，大黄15-25份，当归15-25份，苦参15-25份，白藓皮15-25份，公英15-25份，王不留行15-25份，青黛5-15份；
    按重量份计，所述药物组合物B包括以下中药原料：
    野菊花15-25份，七叶一枝花15-25份，徐长卿15-25份，龙胆草15-25份，柴胡15-25份，黄芩15-25份，鬼箭羽15-25份，泽泻15-25份，地龙15-25份，木通15-25份，车前子15-25份，白术15-25份，陈皮15-25份，野菊花15-25份，蒲公英15-25份。
  2. 权利要求1所述药物组合物在制备治疗重度烧伤及皮肤坏疽的药物中的应用。
  3. 一种治疗重度烧伤及皮肤坏疽的药物制剂，其特征在于，所述药物制剂包括权利要求1所述的中药组合物。
  4. 根据权利要求3所述的药物制剂，其特征在于，所述的药物制剂包括外用喷剂A和内服粉剂B；
    按重量份计，所述外用喷剂A包括以下中药原料：
    金银花15-25份，板蓝根15-25份，蟾蜍皮15-25份，大黄15-25份，当归15-25份，苦参15-25份，白藓皮15-25份，公英15-25份，王不留行15-25份，青黛5-15份；
    所述内服粉剂B包括以下中药原料：
    野菊花15-25份，七叶一枝花15-25份，徐长卿15-25份，龙胆草15-25份，柴胡15-25份，黄芩15-25份，鬼箭羽15-25份，泽泻15-25份，地龙15-25份，木通15-25份，车前子15-25份，白术15-25份，陈皮15-25份，野菊花15-25份，蒲公英15-25份。
  5. 根据权利要求4所述的药物制剂，其特征在于，按重量份计，所述外用喷剂A包括以下中药原料：金银花20份，板蓝根20份，蟾蜍皮20份，大黄20份，当归20份，苦参20份，白藓皮20份，公英20份，王不留行20份，青黛10份；
    所述内服粉剂B包括以下中药原料：野菊花20份，七叶一枝花20份，徐长卿20份，龙胆草20份，柴胡20份，黄芩20份，鬼箭羽20份，泽泻20份，地龙20份，车前子20份，白术20份，陈皮20份，野菊花20份，蒲公英20份。
  6. 一种权利要求4或5任一项所述药物制剂的制备方法，包括以下步骤：
    所述外用喷剂A是将各中药原料浸泡后煮沸，然后文火煎煮后去渣留药液；或者，将各中药原料用40-65°白酒泡制一月以上后去渣留药液；
    所述内服粉剂B是将各中药原料粉碎研磨后过60-200目筛。
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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1157734A (zh) * 1996-08-21 1997-08-27 姚明佐 烧创溃康药
US6468553B1 (en) * 2000-05-05 2002-10-22 Pharmaceutical Industry Technology And Development Center Formula and preparation method of an improved ointment for treating burns and scalds
CN1709331A (zh) * 2005-06-11 2005-12-21 范传运 一种烧烫创疡油及其配制方法和用途
US20080181919A1 (en) * 2007-01-31 2008-07-31 Kaohsiung Medical University Shiunko nanomicell for skin treatment and preparation method for the same
CN102091257A (zh) * 2011-02-19 2011-06-15 孙铭晓 一种治疗新生儿脓疱疮的中药洗剂
CN104740039A (zh) * 2013-12-25 2015-07-01 盖春美 一种治疗脓耳的中药口服汤剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1164299C (zh) * 2001-09-07 2004-09-01 张印昌 治疗急慢性炎症的中药制剂克炎口服液及制作方法
CN102048894B (zh) * 2010-12-22 2013-03-13 陈远征 一种治疗烧伤的中药组合物及其制备方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1157734A (zh) * 1996-08-21 1997-08-27 姚明佐 烧创溃康药
US6468553B1 (en) * 2000-05-05 2002-10-22 Pharmaceutical Industry Technology And Development Center Formula and preparation method of an improved ointment for treating burns and scalds
CN1709331A (zh) * 2005-06-11 2005-12-21 范传运 一种烧烫创疡油及其配制方法和用途
US20080181919A1 (en) * 2007-01-31 2008-07-31 Kaohsiung Medical University Shiunko nanomicell for skin treatment and preparation method for the same
CN102091257A (zh) * 2011-02-19 2011-06-15 孙铭晓 一种治疗新生儿脓疱疮的中药洗剂
CN104740039A (zh) * 2013-12-25 2015-07-01 盖春美 一种治疗脓耳的中药口服汤剂

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