WO2021125075A1 - 低用量ピル服用者への月経関連情報報知システム - Google Patents

低用量ピル服用者への月経関連情報報知システム Download PDF

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Publication number
WO2021125075A1
WO2021125075A1 PCT/JP2020/046218 JP2020046218W WO2021125075A1 WO 2021125075 A1 WO2021125075 A1 WO 2021125075A1 JP 2020046218 W JP2020046218 W JP 2020046218W WO 2021125075 A1 WO2021125075 A1 WO 2021125075A1
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Prior art keywords
information
dose
low
pill
user
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English (en)
French (fr)
Japanese (ja)
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石井　健一
弘一 渡部
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Nextinnovation Inc
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Nextinnovation Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients

Definitions

  • the present invention relates to a system for notifying menstruation-related information (eg, menstrual days, side effect information) to users taking oral contraceptives OC (Oral Controltives), so-called low-dose pills.
  • menstruation-related information eg, menstrual days, side effect information
  • oral contraceptives OC Oral Controltives
  • Low-dose pills are being taken as one of the contraceptive measures.
  • low-dose pills are not only a means of contraception, but also reduce dysmenorrhea (dysmenorrhea), improve menstrual irregularities, prevent and improve endometriosis, reduce premenstrual symptoms (PMS), and acne / hirsutism. It is also used to improve menopausal symptoms and prevent dysmenorrhea.
  • low-dose pills should be taken at approximately fixed times each day.
  • menstrual period menstrual period
  • QOL quality of life
  • the present invention provides novel menstruation-related information that allows a low-dose pill user to be notified by a third party of, for example, near the menstrual day (menstrual day) without having to manage the menstrual day by himself / herself.
  • the main issue is to provide a notification system.
  • Examples of the present invention include the following.
  • the devices) and the information device (administrator information device) on the administration side and the information device terminal (user terminal) on the low-dose pill user side are connected via a telecommunication line, and the following A system for notifying low-dose pill users of menstruation-related information, which comprises the steps 1 to 3 of the above: 1.
  • the user terminal in the process of transmitting the dose execution information together with the user ID to the administrator information device, 2.
  • the administrator information device that has received the dosing execution information accumulates the electronic data information, and monitors the dosing progress of the ID taker based on the accumulated information, and 3. Based on the monitoring of the progress of administration, the administrator information device is a step of transmitting menstruation-related information to the user terminal or information communication device of the ID user.
  • the menstruation-related information notification system for low-dose pill users according to the above [1], which further comprises one or more steps of any one of the following a to d: a.
  • the administrator information device that determines from the monitoring of the course of administration that the low-dose pill has not been taken within the range of 1 to 3 days, or that the low-dose pill has not been taken at the time of taking the ID user, is the same.
  • the process of transmitting information notifying that to the user terminal or information communication device of the ID user b.
  • the administrator information device is a process of transmitting information notifying that the time is around the time of administration of the ID user to the user terminal or information communication device of the ID user.
  • the administrator information device is information for accelerating or delaying the menstruation of the ID user, and transmits the start date or end date of taking the medium-dose pill to the user terminal or information communication device of the ID user. Steps and d.
  • the administrator information device is a process of transmitting information on side effects that may occur due to taking a low-dose pill to a user terminal or an information communication device.
  • the present invention even if a person taking a low-dose pill does not manage or be aware of the menstrual day, he / she can lead a daily life while grasping the menstrual day (menstrual day) by a report from a third party. Can improve medication compliance for low-dose pill users.
  • the menstruation-related information notification system (hereinafter referred to as "the system of the present invention") for low-dose pill users according to the present invention is installed in a pill case capable of storing a PTP packaging sheet containing a low-dose pill.
  • the system of the present invention is installed in a pill case capable of storing a PTP packaging sheet containing a low-dose pill.
  • devices capable of telecommunications (information and communication devices) and information devices on the dose manager side (administrator information device) and between information devices on the dose manager side (administrator information device) and low-dose pills
  • the information device terminals (user terminals) on the user side are connected via a telecommunication line, and are characterized by including the following steps 1 to 3. 1. 1.
  • the information and communication device contained in the pill case, or taking the low-dose pill which senses that the low-dose pill is about to be taken or would have been taken due to the actions of the low-dose pill taker.
  • the user terminal on the user side sends the dose execution information to the administrator information device together with the user ID. 2.
  • the administrator information device that has received the dosing execution information accumulates the electronic data information, and monitors the dosing progress of the ID taker based on the accumulated information, and 3. Based on the monitoring of the progress of administration, the administrator information device transmits menstruation-related information to the user terminal or information communication device of the ID user.
  • the information communication device and the administrator information device, and the administrator information device and the user terminal are usually connected wirelessly or by wire via a telecommunication line such as the Internet.
  • the information communication device and the user terminal may be connected wirelessly or by wire via a telecommunication line such as the Internet.
  • the "telecommunications line” refers to a communication network capable of electrically transmitting information such as video, audio, and text, and specific examples thereof include the Internet and (mobile) telephone lines. However, it is usually the Internet.
  • “Low-dose pills” are drugs (tablets) in which the amount of two types of female hormone drugs, such as progesterone and estrogen, is reduced to the minimum amount at which a contraceptive effect can be obtained.
  • the female hormone drug reduces follicle-stimulating hormone (FSH) and luteinizing hormone (LH) secreted from the brain, inhibits follicle growth, and prevents ovulation.
  • FSH follicle-stimulating hormone
  • LH luteinizing hormone
  • progesterone thickens the endometrium, making it difficult for sperms to implant in the uterus, and thickens the mucus in the cervical canal at the entrance of the uterus, making it difficult for sperms to enter the uterus.
  • low-dose pill progesterone drugs examples include desogestrel, levonorgestrel, norethisterone, and drospirenone.
  • low-dose pill egg yolk hormone drugs examples include ethinyl estradiol and estradiol.
  • Low-dose pills are available in Japan, for example, as Tricular® Tablets, Maveron® Tablets, Labelfille® Tablets, Synphase® Tablets, Anju® Tablets, France (Registered Trademark). It is sold under trade names such as Trademark) Tablets, Yards® Combination Tablets, Lunabell® Combination Tablets, and Friwell® Combination Tablets.
  • Low-dose pills include those containing 21 tablets in a PTP packaging sheet (1 cycle to 1 course) and those containing 28 tablets.
  • the 21-tablet type contains the active ingredient (female hormone drug), and after taking the drug for 3 weeks, the drug is withdrawn for 1 week, and this is considered as 1 course.
  • the 28-tablet type is a placebo drug that contains the active ingredient (female hormone drug) in 21 tablets and no active ingredient in the remaining 7 tablets, and after taking the drug for 3 weeks. I took a placebo for a week, and this is one course. Also, regarding the 21 tablets containing the active ingredient, the hormone amount is all constant, 6 tablets taken first, 5 tablets taken next, and 10 tablets taken last. Is gradually increasing. For low-dose pills such as Trickular® tablets and Labelfille® tablets, there are 21-tablet type and 28-tablet type in PTP packaging sheets, but the amount of hormone is gradually increased. ..
  • the content of the first 6 tablets is 0.050 mg for progesterone, 0.030 mg for progesterone, and then For the 5 tablets taken in, the progesterone drug is 0.075 mg and the egg yolk hormone drug is 0.040 mg, and for the last 10 tablets taken, the progesterone drug is 0.125 mg and the egg yolk hormone drug is 0.030 mg. ..
  • the progesterone drug is 0.125 mg and the egg yolk hormone drug is 0.030 mg. ..
  • low-dose pills such as Maveron (registered trademark)
  • there are 21-tablet type and 28-tablet type in the PTP packaging sheet similar to Trickular (registered trademark) tablets, but the amount of hormone is constant. ..
  • the content thereof is 0.15 mg for the progesterone drug and 0.03 mg for the egg yolk hormone drug.
  • low-dose pills depends on the type of low-dose pill, but as a general rule, it should be started on the first or second day of menstruation or on the Sunday when menstruation begins. Then, take one tablet daily in the determined tablet order at the time determined by oneself. Because the tablets are taken daily in a fixed order, which of the blister packs containing low-dose pills is usually taken from the first tablet to the 21st to 28th tablets. Is there or is basically shown. Failure to adhere to this may result in insufficient effectiveness as a low-dose pill. In that respect, it differs from general drugs.
  • Step 1 is an information and communication device included in the pill case that senses that the low-dose pill is about to be taken or would have been taken due to the actions of the low-dose pill taker.
  • reference numeral 2 or the user terminal on the side of the user who took the low-dose pill (reference numeral 4 in the drawing) transmits the administration execution information together with the user ID to the administrator information device (reference numeral B in the drawing). Is.
  • the pill case according to the present invention can store a PTP packaging sheet (reference numeral 1 in the drawing) containing a low-dose pill, and has a low dose due to the actions of a low-dose pill user. It is not particularly limited as long as it has a device capable of detecting that the pill is about to be taken or that it will have been taken (hereinafter, also referred to as "dose sensing device"; reference numeral 3 in the drawing).
  • the dose sensing device 3 is connected to the information communication device 2. Examples of the form of the pill case include a wallet type, a business card case type, a pouch type, and a box type.
  • the information communication device 2 is not particularly limited as long as it can transmit electronic data information via a telecommunication line. This is usually installed in a pill case containing a PTP packaging sheet 1 containing a low dose pill.
  • the taker takes the PTP packaging sheet 1 out of the pill case and after taking it.
  • the dosing sensing device 3 senses that the weight of the PTP packaging sheet 1 is decreasing, and a low-dose pill is released from the PTP packaging sheet 1. This can be done by sensing traces of extruding (eg, tearing of the discharge surface of the PTP packaging sheet 1 or disappearance of one low-dose pill).
  • the dosing sensing device 3 detects that the pill case has been opened. Can be done.
  • the dose sensing device 3 can transmit the sensing information to the information communication device 2.
  • the sensed information is the information communication included in the pill case.
  • the information and communication device 2 transmitted to the device 2 and received the transmission considers that the user has taken the low-dose pill, and transmits the administration execution information together with the user ID to the administrator information device B.
  • the user ID is for identifying the user, and if it is possible, the type of ID is not particularly limited. Generally, the ID is a character string consisting of numbers, alphabets (uppercase and lowercase letters), hyphens, etc., or electronic data corresponding thereto.
  • the user who has taken the low-dose pill can also use the user terminal 4 to transmit the administration execution information to the administrator information device B. In this case, the user terminal 4 transmits the dose execution information together with the user ID to the administrator information device B.
  • the administrator information device B that receives the transmitted dose execution information and the user ID (hereinafter, also referred to as “dose execution information, etc.”) can receive at least electronic data information, and stores and stores the information.
  • the device is not particularly limited as long as it is a device capable of monitoring the administration progress of the ID user according to the next step.
  • Examples of the administrator information device B include computers such as personal computers (PCs), supercomputers, and embedded computers, and mobile terminals such as smartphones, tablets, and mobile phones, which are terminal devices having a user interface function. It may be a host computer such as a server.
  • Step 2 is a step in which the administrator information device B, which has received the dosing execution information and the like, accumulates the electronic data information and monitors the dosing progress of the ID user based on the accumulated information. ..
  • the administrator information device B mainly stores the dose execution information, etc., grasps the transmission date, etc. of the dose execution information, etc. from the user terminal 4, and calculates the transmission days, period, etc. Is done by.
  • the transmission date and time and the user information and the like are usually grasped by the data processing means in the administrator information device B.
  • the number of non-transmission days, the period of administration and the period of non-administration of the user are calculated. All of these data are usually stored (stored) in a suitable storage medium.
  • the data processing means include processors such as CPUs, MPUs, and GPUs.
  • Suitable storage media include, for example, magnetic recording devices (hard disks, etc.), optical disks (CD, DVD, Blu-ray (registered trademark), etc.), optical magnetic recording media, semiconductor memories (flash memory, DRAM, SRAM, etc.). Can be mentioned.
  • time of administration As mentioned above, those who take low-dose pills for the first time should take the first tablet on the first or second day of menstruation, or on the first Sunday when menstruation begins, at a time determined by themselves (hereinafter referred to as "time of administration"). .) Take around.
  • the administrator information device B When the dose execution information and the user ID of the user are transmitted from the information communication device 2 or the user terminal 4 to the administrator information device B, the administrator information device B receives them and processes internal data.
  • the means grasps that the user has taken the first tablet and the date and time thereof, and stores these data in the storage medium.
  • the dosing time can be stored and managed in the administrator information device B in advance by notification from the taking person, but it is also possible to store and manage the time when the first tablet is transmitted as the taking time.
  • the tablets taken from the first tablet to the 21st tablet (final) to the 28th tablet (final) are basically taken on the PTP packaging sheet in which it is stored. It is decided to. If you do not follow it, you may not be able to get the desired low-dose pill effect.
  • the administrator information The device B grasps that the user has taken the second tablet and the date and time of taking the second tablet by the data processing means, and stores it in the storage medium together with the administration execution information and the like. Similarly, every day, the dose execution information and the like of the user are stored in the storage medium of the administrator information device B. In this way, the administration information and the like of the user are accumulated in the administrator information device B. At this time, the total number of transmission days and non-transmission days up to that point, the dosing period and the non-dosing period of the user are calculated by the data processing means, and these data are also accumulated in the same manner.
  • the administrator information device B does not receive the dosing execution information, etc. within the range of 1 to 3 days, or even if one hour has passed from the dosing time of the ID user, the dosing execution information, etc. If the administrator information device B does not receive the information, the administrator information device B can also transmit information notifying the fact to the user terminal 4 or the information communication device 2 of the ID user. Examples of the notification information include "I cannot confirm the previous day's dose” and "I cannot confirm today's dose even after 1 hour has passed from the time of administration.” Such notifications can inform you that you have forgotten to take the drug and improve your compliance with low-dose pills. If the low-dose pill is not taken for 3 days or more, the effect of the low-dose pill cannot be fully obtained (reset). Therefore, in order to obtain the effect, tablets (21 tablets) for the total number of days taken. Or you may have to start over with a new PTP packaging sheet containing (28 tablets).
  • the administrator information device B can also transmit information notifying that the time is taken by the ID user to the user terminal 4 or the information communication device 2 of the ID user. Such notifications can help prevent forgetting to take the day and improve low-dose pill compliance.
  • Step 3 is a step in which the administrator information device B transmits menstruation-related information to the user terminal 4 or the information communication device 2 of the ID user based on the monitoring of the administration progress.
  • the administrator information that normally receives the low-dose pill administration execution information and the like from the first tablet to the 21st tablet, and stores and accumulates the above-mentioned data grasped and calculated from them.
  • the device B calculates the menstrual-related information of the ID user by the data processing means and notifies the user terminal 4 or the information communication device 2 of the ID user.
  • Menstruation-related information may include, for example, the day when menstruation will begin.
  • the notification date in addition to the date desired by the user, for example, the date when the administrator information device B receives the 21st tablet, and the day between the following day and about 3 days later can be mentioned. Further, the notification date may be a day (eg, the day before, the day before the previous day) before the day when the administrator information device B receives the 21st tablet, if necessary.
  • the notification may be performed not only once but also a plurality of times, and the content of the notification may be different for each time. As a result, the user can easily grasp the day when menstruation begins without having to manage the menstrual period by himself / herself. If menstruation does not start even if the notification is given, the possibility of pregnancy can be suspected.
  • the administrator information device B When the administrator information device B receives the administration information of all 21 tablets for 21 days, it is preferable that the administrator information device B notifies the user terminal 4 or the like that menstruation starts, but one day in 21 days. Alternatively, even if the administration information for the 2nd day is not received, the administrator information device B can notify the user terminal 4 or the like of the ID user that menstruation will start. In that case, it is also possible to notify that there is a day when the patient did not take the drug and that the day when menstruation starts may be different.
  • the administrator information device B may notify the user terminal 4 or the information communication device 2 of the ID user to that effect. This allows the recipient to know that the next course is about to begin, i.e., that the next new low-dose pill on the PTP packaging sheet must be taken, and can improve medication compliance.
  • 28 days is one course, and steps 1 to 3 of the system of the present invention are usually repeated every 28 days.
  • steps 1 to 3 of the system of the present invention are usually repeated every 28 days.
  • the menstrual start date of the ID user is almost specified, so that the administrator information device B can notify the user of highly accurate information. Will be.
  • the date when menstruation starts may not be sufficiently specified, so the administrator information device B notifies the user's terminal etc. to that effect. You may.
  • the administrator information device B is information for accelerating or delaying the menstruation of the ID user, and sets the start date or end date of taking the medium-dose pill to the user terminal 4 or the information communication device 2 of the ID user.
  • the administrator information device B is a step of transmitting information on side effects that may occur due to taking a low-dose pill to the user terminal 4 or the information communication device 2.
  • Step c relates to the step of notifying information for menstrual transfer with medium dose pills.
  • Step d relates to a step of notifying side effect information due to taking a low dose pill.
  • the administrator information device B may, for example, start menstruation on the day when the menstruation notified by step 3 starts or actually starts menstruation. Information that you should start taking medium-dose pills on the day between the first day and the 5th day, and stop taking medium-dose pills on the day 2-3 days before the desired start date of menstruation that you want to accelerate. Information that should be done can be transmitted to the user terminal 4 or information communication device 2 of the low-dose pill user.
  • the administrator information device B that has received the dosing execution information around the 17th to 19th tablets starts taking the medium-dose pill. If the administrator information device B knows in advance the information that it should be avoided and the day when you want to avoid menstruation by prior notification etc., for example, the information that you should stop taking the medium-dose pill on that day, It can be transmitted to the user terminal 4 or the information communication device 2 of the low-dose pill user. As a result of the above, low-dose pill users who desire menstrual transfer can know when to take the medium-dose pill by notification from a third party, and can improve the compliance with the medium-dose pill.
  • Medium-dose pills like low-dose pills, contain progesterone and estrogen, but in larger amounts than low-dose pills.
  • Medium-dose pills are commercially available under trade names such as Planovar® and Sophia A®.
  • Planovar® a combination tablet of norgestrel and ethinyl estradiol, contains 0.5 mg of norgestrel (progesterone) and 0.05 mg of ethinyl estradiol (egg yolk hormone), more than low-dose pills.
  • the above-mentioned side effect information can be transmitted to the user terminal 4 or the like of the low-dose pill user to notify the user.
  • the user terminal 4 of the person taking the low-dose pill transmits information on the side effect caused to the person taking the low-dose pill to the administrator information device B, the administrator information device B accumulates the side effect information, and the administrator information device B Can be transmitted to the user terminal 4 or the like of another user.
  • the administrator information device B can be transmitted to the user terminal 4 or the like of another user.
  • information on side effects caused by taking low-dose pills can be returned to low-dose pill users and shared among low-dose pill users.
  • the system of the present invention includes a step in which the administrator information device B, which has accumulated information on side effects that may occur due to taking a low-dose pill, transmits the information to the user terminal 4 or the information communication device 2. Can be done.
  • the pill case (hereinafter referred to as “the pill case of the present invention") that can store the PTP packaging sheet containing the low-dose pill according to the present invention is a low-dose pill.
  • the pill case of the present invention usually has a size, shape, and the like that can accommodate a commercially available low-dose pill PTP packaging sheet. It is preferable that the PTP packaging sheet has a size and shape that can store one to several sheets so that it can be easily carried, but the PTP packaging sheet is not limited thereto.
  • Examples of the form of the pill case of the present invention include a wallet type, a business card case type, a pouch type, a box type, a smartphone case type, a compact (foundation case) type, and a pen case type.
  • the taker is the PTP.
  • a weigh scale that can detect that the weight of the PTP packaging sheet is decreasing when the packaging sheet is taken out of the pill case, taken, and then returned to the pill case, and a low-dose pill is the subject. Examples include sensors capable of detecting traces of being extruded from a PTP packaging sheet (eg, tearing of the discharge surface of the PTP packaging sheet or disappearance of one low-dose pill). Alternatively, in the case of a pill case in which the removal of the PTP packaging sheet is limited to, for example, once a day, a sensor capable of detecting that the pill case has been opened or that the PTP packaging sheet has been taken out. And so on.
  • a device capable of transmitting the information detected by the dose sensing device to the administrator information device via the telecommunication line
  • electronic data information can be transmitted via the telecommunication line.
  • a device having a computer having various functions can be mentioned.
  • the computer of the device has a built-in processor such as a CPU, MPU, and GPU.
  • the system of the present invention is useful for low-dose pill users to know the menstrual period (the day when menstruation begins) and for to safely and safely take low-dose pills. Therefore, the system of the present invention is also useful for market distribution of low-dose pills.
  • a pill case (pill case of the present invention)
  • B Administrator information device 1
  • Low-dose pill storage PTP packaging sheet 2
  • Information and communication device 3
  • Dosing detector 4 Taker terminal

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
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PCT/JP2020/046218 2019-12-18 2020-12-11 低用量ピル服用者への月経関連情報報知システム Ceased WO2021125075A1 (ja)

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Citations (3)

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JP2003016185A (ja) * 2001-06-27 2003-01-17 Casio Joho Kiki Kk 医薬品服用督促通知システムおよび方法、管理センタ、及びプログラム
JP2018068743A (ja) * 2016-10-31 2018-05-10 株式会社Ｙｏｏｄｓ 服薬管理装置とそのシステム
JP2019510587A (ja) * 2016-04-08 2019-04-18 クアンテッド・エルエルシー 向上した投薬計画順守のための装置及び方法

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JP2016091419A (ja) * 2014-11-07 2016-05-23 株式会社Ｎｔｔドコモ 端末装置、服薬支援方法、プログラム
JP6697951B2 (ja) * 2016-05-18 2020-05-27 株式会社エムティーアイ 経口避妊薬服用スケジューリングシステム、経口避妊薬服用スケジューリング方法、及びプログラム

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JP2003016185A (ja) * 2001-06-27 2003-01-17 Casio Joho Kiki Kk 医薬品服用督促通知システムおよび方法、管理センタ、及びプログラム
JP2019510587A (ja) * 2016-04-08 2019-04-18 クアンテッド・エルエルシー 向上した投薬計画順守のための装置及び方法
JP2018068743A (ja) * 2016-10-31 2018-05-10 株式会社Ｙｏｏｄｓ 服薬管理装置とそのシステム

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