WO2021121149A1 - 一种全血分离结构 - Google Patents

一种全血分离结构 Download PDF

Info

Publication number
WO2021121149A1
WO2021121149A1 PCT/CN2020/135696 CN2020135696W WO2021121149A1 WO 2021121149 A1 WO2021121149 A1 WO 2021121149A1 CN 2020135696 W CN2020135696 W CN 2020135696W WO 2021121149 A1 WO2021121149 A1 WO 2021121149A1
Authority
WO
WIPO (PCT)
Prior art keywords
flow channel
tank
separation
separation tank
plasma
Prior art date
Application number
PCT/CN2020/135696
Other languages
English (en)
French (fr)
Inventor
郝书顺
Original Assignee
石家庄禾柏生物技术股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 石家庄禾柏生物技术股份有限公司 filed Critical 石家庄禾柏生物技术股份有限公司
Publication of WO2021121149A1 publication Critical patent/WO2021121149A1/zh

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B01D17/02—Separation of non-miscible liquids
    • B01D17/0217—Separation of non-miscible liquids by centrifugal force

Definitions

  • the invention relates to a whole blood separation structure.
  • the technical problem to be solved by the present invention is to provide a whole blood separation structure that can automatically separate and take out the whole blood.
  • the technical solution adopted by the present invention is: a whole blood separation structure, which includes a turntable, a liquid storage tank arranged on the turntable, a separation tank connected with the liquid storage tank through a first flow channel, and a second separation tank arranged on the separation tank. Runner.
  • An inflection point is provided on the second flow path, and the radial distance between the inflection point and the rotation axis of the turntable is smaller than the radial distance between the liquid surface in the separation groove and the rotation axis of the turntable.
  • volume of the outside of the communication point between the separation tank and the second flow channel is greater than 70% of the volume of blood added in the liquid storage tank.
  • the separation tank includes a blood cell tank and a plasma tank that are connected through a third flow path, the second flow path is in communication with the third flow path, and the third flow path is located outside the connection point with the second flow path.
  • the sum of the volume of the blood cell tank is greater than 70% of the volume of blood added in the reservoir.
  • the second flow channel is U-shaped, and the position of the U-shaped bottom end is radially inward with respect to the liquid surface in the separation tank.
  • the blood plasma tank is connected with an overflow tank through a fourth flow channel.
  • the radial distance between the overflow groove and the rotation axis of the turntable is greater than the radial distance between the plasma tank and the rotation axis of the turntable.
  • the positive effect of the present invention is that the present invention generates centrifugal force through the turntable. Under the action of the centrifugal force, the whole blood added from the liquid storage tank is pushed into the separation tank, and the plasma and blood cells are separated in the separation tank. Due to the quality of blood cells Larger, it will be located at the end of the separation tank far away from the rotation axis, and the plasma is located at the end of the separation tank close to the rotation axis. Since the separation tank has no vent, when the liquid level in the separation tank is below the gap between it and the second flow channel After the connection point, the gas in it will be compressed.
  • the turntable When the separation is completed, the turntable will decelerate, and the plasma will be pushed into the second flow channel under the action of air pressure, bypassing the inflection point of the second flow channel, and then the turntable will accelerate again , The plasma will be discharged from the second flow channel for the next step.
  • Figure 1 is a schematic diagram of the structure of the present invention.
  • the present invention includes a turntable 1, a liquid storage tank arranged on the turntable 1 near the position of its axis of rotation 2, a separation tank communicating with the liquid storage tank 2 through a first flow channel 3, and a separation tank arranged in the separation tank On the upper second flow channel 6, the distance between the separation groove and the rotation axis is greater than the distance between the liquid storage tank 2 and the rotation axis, that is, the separation groove is more radially outward than the liquid storage tank 2.
  • An inflection point is provided on the second flow channel 6, and the radial distance between the inflection point and the rotation axis of the turntable 1 is smaller than the radial distance between the liquid level in the separation groove and the rotation axis of the turntable 1. In this way, according to the principle of the communicating device, it can be ensured that when the turntable rotates for centrifugal separation, the liquid in the second flow channel 6 will not bypass the inflection point and flow out.
  • the second flow channel 6 is U-shaped, and the position of the bottom end of the U-shape is the inflection point.
  • the volume outside the communication point between the separation tank and the second flow channel 6 is greater than 70% of the blood volume in the reservoir 2, and of course it cannot exceed the volume of blood added. Blood volume, otherwise the liquid cannot be discharged.
  • the separation tank includes a blood cell tank 4 and a plasma tank 5 connected by a third flow channel, the first flow channel 3 is in communication with the blood cell tank 4, and the second flow channel 6 is in communication with the third flow channel.
  • the sum of the volume of the part of the third flow channel outside the connection point with the second flow channel 6 and the volume of the blood cell tank 4 is greater than 70% of the blood volume added in the liquid storage tank 2.
  • an overflow groove 8 is connected to the blood plasma tank 5 through the fourth flow channel 7.
  • the radial distance between the overflow groove 8 and the rotation axis of the turntable 1 is greater than that of the blood plasma tank 5 and the turntable 1 The radial distance of the axis.
  • the turntable 1 can be driven to rotate in various forms, for example, in a form of an optical disc drive similar to a CD/DVD, which belongs to the prior art for those skilled in the art, and will not be repeated here.
  • the present invention When the present invention is in use, blood is added to the liquid storage tank 2 from the liquid filling port on the liquid storage tank 2, and then the turntable rotates. Under the action of centrifugal force, the whole blood is pushed into the blood cell tank 4, and the tank is centrifuged. , The gas in the plasma tank 5 is compressed. After the separation is completed, the turntable 1 decelerates and the compressed gas expands, pushing the plasma into the second flow path 6 and bypassing the inflection point of the second flow path 6, and the turntable 1 accelerates again. Based on the principle of the device, the plasma will be discharged from the second flow channel 6 for the next test and detection operation.

Landscapes

  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Centrifugal Separators (AREA)
  • External Artificial Organs (AREA)

Abstract

一种全血分离结构，其包括转盘(1)、储液槽(2)、分离槽以及第二流道(6)，在第二流道(6)上设置有一拐点，该拐点与转盘(1)旋转轴心的径向距离小于分离槽内的液面与转盘(1)旋转轴心的径向距离。通过转盘(1)产生离心力，将从储液槽(2)内加入的全血推入到分离槽内，在分离槽内进行血浆与血细胞的分离，由于血细胞质量较大，会位于分离槽远离旋传轴心的一端，血浆位于分离槽靠近旋转轴心的一端，而由于分离槽没有排气口，当分离槽内的液面没过其与第二流道(6)的连通点之后便会对其中的气体进行压缩，当分离完成后，转盘(1)减速，在空气压力作用下便会将血浆推入到第二流道(6)内，绕过第二流道(6)的拐点，然后转盘(1)再次加速，血浆便会从第二流道(6)排出，进行下一步的操作。

Description

一种全血分离结构 技术领域
本发明涉及一种全血分离结构。
 背景技术
在试验与现代医疗中，经常需要对全血进行分离，提取血浆进行进一步的试验或检测，目前采用的分离方式多为采用专门的离心机，利用离心力将全血进行分离，再将分离出的血浆取出，进行下一步的操作。虽然全血离心可以由机械自动完成，但是取出血浆进行下一步操作需要由人工完成，耗费一定的人力。
 技术问题
本发明所要解决的技术问题是提供一种可以自动实现全血分离并取出的全血分离结构。
 技术解决方案
本发明所采用的技术方案是：一种全血分离结构，其包括转盘、设置在转盘上的储液槽、通过第一流道与储液槽连通的分离槽以及设置在分离槽上的第二流道。
在第二流道上设置有一拐点，该拐点与转盘旋转轴心的径向距离小于分离槽内的液面与转盘旋转轴心的径向距离。
进一步的，所述分离槽内与第二流道连通点外侧的容积大于储液槽内加血量的70%。
进一步的，所述分离槽包括通过第三流道连通的血细胞槽以及血浆槽，所述第二流道与第三流道连通，第三流道位于与第二流道连接点外侧的部分与血细胞槽的容积之和大于储液槽内加血量的70%。
进一步的，所述第二流道呈U形，其U形底端的位置相对于分离槽内的液面径向靠内。
进一步的，所述血浆槽通过第四流道连通有溢流槽。
进一步的，所述溢流槽与转盘旋转轴心的径向距离大于血浆槽与转盘旋转轴心的径向距离。
 有益效果
本发明的积极效果为：本发明通过转盘产生离心力，在离心力的作用下将从储液槽内加入的全血推入到分离槽内，在分离槽内进行血浆与血细胞的分离，由于血细胞质量较大，会位于分离槽远离旋转轴心的一端，血浆位于分离槽靠近旋转轴心的一端，而由于分离槽没有排气口，当分离槽内的液面没过其与第二流道的连通点之后便会对其中的气体进行压缩，当分离完成后，转盘减速，在空气压力作用下便会将血浆推入到第二流道内，绕过第二流道的拐点，然后转盘再次加速，血浆便会从第二流道排出，进行下一步的操作。
 附图说明
图1为本发明结构示意图。
 本发明的实施方式
如附图1所示，本发明包括转盘1、设置在转盘1上靠近其旋转轴心位置处的储液槽2、通过第一流道3与储液槽2连通的分离槽以及设置在分离槽上的第二流道6，分离槽与旋转轴心之间的距离大于储液槽2与旋转轴心之间的距离，也即分离槽相对于储液槽2更加径向靠外。
在第二流道6上设置有一拐点，该拐点与转盘1旋转轴心的径向距离小于分离槽内的液面与转盘1旋转轴心的径向距离。这样根据连通器原理，可以保证当转盘旋转进行离心分离时，第二流道6内液体不会绕过该拐点流出。第二流道6呈U形，其U形底端的位置即为拐点。
根据全血内血浆与血细胞的占比，为了只排出血浆，所述分离槽内与第二流道6连通点外侧的容积大于储液槽2内加血量的70%，当然也不能超过加血量，否则液体无法排出。
作为本发明的另一个实施例，所述分离槽包括通过第三流道连通的血细胞槽4以及血浆槽5，第一流道3与血细胞槽4连通，第二流道6与第三流道连通，第三流道位于与第二流道6连接点外侧的部分与血细胞槽4的容积之和大于储液槽2内加血量的70%。
作为本发明的进一步改进，在所述血浆槽5通过第四流道7连通有溢流槽8，所述溢流槽8与转盘1旋转轴心的径向距离大于血浆槽5与转盘1旋转轴心的径向距离。当储液槽2内加入的血量较多时，多余的血液进入到溢流槽8内。
转盘1可以通过多种形式驱动旋转，比如采用类似于CD/DVD的光盘驱动的形式，这对于本领域技术人员来说属于现有技术，此处不再赘述。
本发明在使用时，从储液槽2上的加液口向储液槽2加入血液，然后转盘旋转，在离心力的作用下全血被推入到血细胞槽4内，在槽内进行离心分离，血浆槽5内的气体被压缩，分离完成后，转盘1减速，压缩气体膨胀，将血浆从推入第二流道6并绕过第二流道6的拐点，转盘1再次加速，根据连通器的原理，血浆便会从第二流道6排出，以进行下一步的试验检测操作。

Claims (6)

  1. 一种全血分离结构，其特征在于其包括转盘（1）、设置在转盘（1）上的储液槽（2）、通过第一流道（3）与储液槽（2）连通的分离槽以及设置在分离槽上的第二流道（6）；
    在第二流道（6）上设置有一拐点，该拐点与转盘（1）旋转轴心的径向距离小于分离槽内的液面与转盘（1）旋转轴心的径向距离。
  2. 根据权利要求1所述的一种全血分离结构，其特征在于所述分离槽内与第二流道（6）连通点外侧的容积大于储液槽（2）内加血量的70%。
  3. 根据权利要求1或2所述的一种全血分离结构，其特征在于所述分离槽包括通过第三流道连通的血细胞槽（4）以及血浆槽（5），所述第二流道（6）与第三流道连通，第三流道位于与第二流道（6）连接点外侧的部分与血细胞槽（4）的容积之和大于储液槽（2）内加血量的70%。
  4. 根据权利要求1所述的一种全血分离结构，其特征在于所述第二流道（6）呈U形，其U形底端的位置即为拐点。
  5. 根据权利要求3所述的一种全血分离结构，其特征在于所述血浆槽（5）通过第四流道（7）连通有溢流槽（8）。
  6. 根据权利要求5所述的一种全血分离结构，其特征在于所述溢流槽（8）与转盘（1）旋转轴心的径向距离大于血浆槽（5）与转盘（1）旋转轴心的径向距离。
PCT/CN2020/135696 2019-12-19 2020-12-11 一种全血分离结构 WO2021121149A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201911316824.9 2019-12-19
CN201911316824.9A CN110841335A (zh) 2019-12-19 2019-12-19 一种全血分离结构

Publications (1)

Publication Number Publication Date
WO2021121149A1 true WO2021121149A1 (zh) 2021-06-24

Family

ID=69609929

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2020/135696 WO2021121149A1 (zh) 2019-12-19 2020-12-11 一种全血分离结构

Country Status (2)

Country Link
CN (1) CN110841335A (zh)
WO (1) WO2021121149A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110841335A (zh) * 2019-12-19 2020-02-28 石家庄禾柏生物技术股份有限公司 一种全血分离结构
CN111308107A (zh) * 2020-03-02 2020-06-19 石家庄禾柏生物技术股份有限公司 针对新型冠状病毒感染从诊断到确诊的试剂盘及使用方法
CN114509323A (zh) * 2022-02-24 2022-05-17 含光微纳科技(太仓)有限公司 一种离心式微流控全血分离血浆结构

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103464230A (zh) * 2013-09-25 2013-12-25 中国科学院长春光学精密机械与物理研究所 离心式全血分析微流控芯片、制备方法及其应用方法
WO2018078325A1 (en) * 2016-10-24 2018-05-03 Entia Limited A system and method for calibrating a centrifuge
CN108444802A (zh) * 2018-05-11 2018-08-24 石家庄禾柏生物技术股份有限公司 一种测试反应囊
CN108593382A (zh) * 2018-05-11 2018-09-28 石家庄禾柏生物技术股份有限公司 一种全血血浆自动分离装置
CN108982824A (zh) * 2018-05-11 2018-12-11 石家庄禾柏生物技术股份有限公司 一种试剂盘测试装置
CN208270312U (zh) * 2018-05-11 2018-12-21 石家庄禾柏生物技术股份有限公司 一种测试反应囊
CN208270290U (zh) * 2018-05-11 2018-12-21 石家庄禾柏生物技术股份有限公司 一种全血血浆自动分离装置
CN208399504U (zh) * 2018-05-11 2019-01-18 石家庄禾柏生物技术股份有限公司 一种试剂盘测试装置
CN109939754A (zh) * 2019-04-11 2019-06-28 石家庄禾柏生物技术股份有限公司 一种基于离心力的液体输送模块
CN110841335A (zh) * 2019-12-19 2020-02-28 石家庄禾柏生物技术股份有限公司 一种全血分离结构
CN212308929U (zh) * 2019-12-19 2021-01-08 石家庄禾柏生物技术股份有限公司 一种全血分离结构

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103464230A (zh) * 2013-09-25 2013-12-25 中国科学院长春光学精密机械与物理研究所 离心式全血分析微流控芯片、制备方法及其应用方法
WO2018078325A1 (en) * 2016-10-24 2018-05-03 Entia Limited A system and method for calibrating a centrifuge
CN108444802A (zh) * 2018-05-11 2018-08-24 石家庄禾柏生物技术股份有限公司 一种测试反应囊
CN108593382A (zh) * 2018-05-11 2018-09-28 石家庄禾柏生物技术股份有限公司 一种全血血浆自动分离装置
CN108982824A (zh) * 2018-05-11 2018-12-11 石家庄禾柏生物技术股份有限公司 一种试剂盘测试装置
CN208270312U (zh) * 2018-05-11 2018-12-21 石家庄禾柏生物技术股份有限公司 一种测试反应囊
CN208270290U (zh) * 2018-05-11 2018-12-21 石家庄禾柏生物技术股份有限公司 一种全血血浆自动分离装置
CN208399504U (zh) * 2018-05-11 2019-01-18 石家庄禾柏生物技术股份有限公司 一种试剂盘测试装置
CN109939754A (zh) * 2019-04-11 2019-06-28 石家庄禾柏生物技术股份有限公司 一种基于离心力的液体输送模块
CN110841335A (zh) * 2019-12-19 2020-02-28 石家庄禾柏生物技术股份有限公司 一种全血分离结构
CN212308929U (zh) * 2019-12-19 2021-01-08 石家庄禾柏生物技术股份有限公司 一种全血分离结构

Also Published As

Publication number Publication date
CN110841335A (zh) 2020-02-28

Similar Documents

Publication Publication Date Title
WO2021121149A1 (zh) 一种全血分离结构
KR101466923B1 (ko) 재생성 세포 추출장치, 재생성 세포 추출 시스템, 이를 이용한 재생성 세포 추출방법
JP2004531321A5 (zh)
JPH0683801B2 (ja) 血液と生化学的薬液の遠心沈殿セル
JP2008220969A (ja) 血小板及びその他の血液成分を収集するための装置及び方法
CN105251241B (zh) 除泡系统
EP3068542B1 (en) Method and apparatus for controlling flow of components separated from whole blood
EP2826503B1 (en) Blood components separation device, and centrifugal separator
WO2022252910A1 (zh) 一种带内核的活塞式生物液体分离杯及其分离方法
CN212308929U (zh) 一种全血分离结构
CA2258350A1 (fr) Dispositif de compression de gaz humide comportant un etage de compression/separation integrees
EP3974009A1 (en) Centrifuge bowl and blood centrifuge system
CN211133084U (zh) 一种胶粘剂生产用脱泡设备
CN207756296U (zh) 一种水质监测用差速离心装置
CN207839201U (zh) 血液检测用离心装置
CN215308954U (zh) 一种带内核的活塞式生物液体分离杯
CN216396706U (zh) 液肥轻组分分离装置
CN108722685A (zh) 一种生物提取装置
CN212335187U (zh) 一种血液成分自动平衡分离装置
CN203425932U (zh) 一种适用于原油水分测定的离心机用水平转子
CN205164978U (zh) 一种prp专用离心机
CN209138887U (zh) 一种用于离心机的封盖装置
CN206139352U (zh) 一种离心机用浓缩布料机构
CN207203534U (zh) 一种萃取机导流机构
CN207769851U (zh) 血液离心分离用试管固定结构

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20902597

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20902597

Country of ref document: EP

Kind code of ref document: A1