WO2021104171A1 - 杀菌组合物及其应用 - Google Patents

杀菌组合物及其应用 Download PDF

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WO2021104171A1
WO2021104171A1 PCT/CN2020/130513 CN2020130513W WO2021104171A1 WO 2021104171 A1 WO2021104171 A1 WO 2021104171A1 CN 2020130513 W CN2020130513 W CN 2020130513W WO 2021104171 A1 WO2021104171 A1 WO 2021104171A1
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alkyl
halogenated
alkoxy
halogen
hydrogen
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PCT/CN2020/130513
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English (en)
French (fr)
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王军锋
李志念
刘君丽
关爱莹
兰杰
刘长令
孙芹
单忠刚
赵杰
孙庚�
颜克成
王斌
李轲轲
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沈阳中化农药化工研发有限公司
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Publication of WO2021104171A1 publication Critical patent/WO2021104171A1/zh

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
    • A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
    • A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
    • A01N47/44—Guanidine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P3/00—Fungicides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention belongs to the field of agricultural bactericides, and specifically relates to a bactericidal composition of a pyrimidine-containing substituted pyrazole compound and a bactericide and its application.
  • Patent WO2016184378 discloses a pyrimidine-containing substituted pyrazole compound and its use, in which it is reported that the compounds represented by the following general formulas I-A and I-B have good activity against a variety of diseases.
  • Respiratory inhibitor fungicides nucleic acid metabolism inhibitor fungicides, cell wall synthesis inhibitor fungicides, signal transduction inhibitor fungicides, cytoskeleton and motor protein inhibitor fungicides, sterol biosynthesis inhibitors
  • Fungicides, phospholipid synthesis inhibitor fungicides, cell wall synthesis inhibitor fungicides, and methionine biosynthesis inhibitor fungicides are widely used in agricultural production and have outstanding control effects. Because of its single site of action, after long-term repeated use, the field efficacy of some varieties will decrease significantly. Multi-site inhibitor fungicides are a broad-spectrum protective fungicide, but this type of fungicide has poor therapeutic activity and is used in large fields.
  • Pesticide combination application is an important means to delay the development of resistance of pathogenic bacteria, and it is also an effective way to reduce the dosage of pesticides.
  • the scientific nature of the combined application of fungicides depends not only on the control object and mechanism of action, but also on the nature of the combined action after the medicaments are mixed. Therefore, the development of a high-efficiency bactericide composition with complementary effects and significant synergy has many constraints, and the success rate is extremely low.
  • the purpose of the present invention is to provide a synergistic bactericidal composition of a pyrimidine-containing substituted pyrazole compound and a bactericide and its use.
  • a bactericidal composition the composition is composed of two active components A and B, and the weight ratio between the active component A and the active component B is 1:99-99:1;
  • the active component A is one or more of pyrimidine-containing substituted pyrazole compounds or their salts; the active component B is selected from a fungicide.
  • Active component A is a compound represented by general formula I-A or I-B or a salt thereof:
  • R 1 is selected from hydrogen, halogen, cyano, nitro, amino, carboxy, C 1 -C 4 alkyl, halo C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, halogenated C 1 -C 4 alkylthio, C 1 -C 4 alkylsulfinyl, C 1 -C 4 alkylsulfonyl, C 2 -C 4 alkenyl, halo C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, halo C 2 -C 4 alkynyl, C 3 -C 4 alkenyloxy , Halogenated C 3 -C 4 alkenyloxy, C 3 -C 4 alkynyloxy, halogenated C 3 -C 4 alkynyloxy, C
  • R 2 is selected from hydrogen, halogen, cyano, nitro, amino, carboxy, formyl, C 1 -C 4 alkyl, halo C 1 -C 4 alkyl, C 1 -C 4 alkoxy or halo C 1 -C 4 alkoxy;
  • R 3 is selected from hydrogen, hydroxyl, formyl, C 1 -C 4 alkyl, halogenated C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogenated C 1 -C 4 alkoxy, C 3 -C 4 cycloalkyl, C 1 -C 4 alkylthio, C 2 -C 4 alkenylthio, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, halogenated C 2 -C 4 Alkenyl, halogenated C 2 -C 4 alkynyl, C 1 -C 4 alkoxy C 1 -C 4 alkyl, halogenated C 1 -C 4 alkoxy C 1 -C 4 alkyl, C 1- C 4 alkylthio C 1 -C 4 alkyl, halogenated C 1 -C 4 alkylthio C 1 -C 4 alkyl, C 1 -C 4 alkylsulfin
  • R 4 and R 5 may be the same or different, and are respectively selected from hydrogen, halogen, C 1 -C 4 alkyl, halo C 1 -C 4 alkyl, C 1 -C 4 alkoxy or halo C 1 -C 4 Alkoxy; wherein R 4 , R 5 and the C connected to it can also form a C 3 -C 4 ring;
  • R 6 and R 7 may be the same or different, and are respectively selected from hydrogen, halogen, C 1 -C 4 alkyl, halo C 1 -C 4 alkyl, C 1 -C 4 alkoxy or halo C 1 -C 4 Alkoxy; wherein R 6 , R 7 and the C connected to it can also form a C 3 -C 4 ring;
  • R 8 and R 9 may be the same or different, and are selected from hydrogen, cyano, halogen, C 1 -C 4 alkyl, halogenated C 1 -C 4 alkyl, C 1 -C 4 alkoxycarbonyl, halogenated C 1 -C 4 alkoxycarbonyl, unsubstituted or substituted with 1-5 R 11 aryl, arylmethyl, arylcarbonyl, arylmethylcarbonyl, aryloxycarbonyl, heteroaryl, heteroaryl Methyl, heteroarylcarbonyl, heteroarylmethylcarbonyl or heteroaryloxycarbonyl;
  • R 11 is selected from halogen, hydroxy, amino, cyano, nitro, C 1 -C 4 alkyl, halo C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halo C 1 -C 4 Alkoxy, C 3 -C 4 cycloalkyl, C 1 -C 4 alkylamino, halogenated C 1 -C 4 alkylamino, two (C 1 -C 4 alkyl) amino, halogenated two (C 1 -C 4 alkyl) amino, C 1 -C 4 alkylthio, halogenated C 1 -C 4 alkylthio, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, C 2 -C 4 Alkenyloxy, halogenated C 2 -C 4 alkenyloxy, C 2 -C 4 alkynyloxy, halogenated C 2 -C 4 alkynyloxy, C 1 -C
  • R 14 , R 15 , R 16 or R 17 may be the same or different, and are respectively selected from hydrogen, halogen, hydroxyl, amino, cyano, nitro, C 1 -C 4 alkyl, and halogenated C 1 -C 4 alkyl , C 1 -C 4 alkoxy, halogenated C 1 -C 4 alkoxy or C 3 -C 4 cycloalkyl;
  • W is selected from hydrogen, halogen, C 1 -C 4 alkyl, halogenated C 1 -C 4 alkyl, C 3 -C 4 cycloalkyl, C 1 -C 4 alkoxy, C 1 -C 4 alkyl sulfide Group or C 1 -C 4 alkylsulfonyl;
  • the salt of the substituted pyrazole compound containing pyrimidine is a compound represented by general formula IA or IB and hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid , Phthalic acid, maleic acid, fumaric acid, sorbic acid, malic acid or citric acid;
  • Active component B is selected from the group consisting of respiratory inhibitor fungicides, nucleic acid metabolism inhibitor fungicides, cell wall synthesis inhibitor fungicides, signal transduction inhibitor fungicides, cytoskeleton and motor protein inhibitor fungicides, solid One or more of alcohol biosynthesis inhibitor fungicides, phospholipid synthesis inhibitor fungicides, methionine biosynthesis inhibitor fungicides, multi-site inhibitor fungicides, and unknown mechanism of action fungicideskind.
  • the composition is the active component A and the active component B in a weight ratio of 1:50-50:1;
  • the active component A is selected from one or more of the compounds in the general formula I-A or their salts;
  • R 3 is selected from hydrogen, hydroxy, formyl, C 1 -C 4 alkyl, halogenated C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogenated C 1 -C 4 alkoxy Group, C 3 -C 4 cycloalkyl, C 1 -C 4 alkylthio, C 2 -C 4 alkenylthio, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, halo C 2 -C 4 alkenyl or halo C 2 -C 4 alkynyl; R 4 and R 5 may be the same or different, and are respectively selected from hydrogen, halogen, C 1 -C 4 alkyl, and halo C 1 -C 4 alkyl , C 1 -C 4 alkoxy or halogenated C 1 -C 4 alkoxy; R 6 and R 7 may be the same or different, and are selected from hydrogen, halogen, C 1 -
  • the salt of the compound represented by the general formula IA is a compound of the general formula with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid.
  • Acid salt is a compound of the general formula with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid.
  • the active component B is selected from benzovindiflupyr B1, penflufen B2, isopyrazam B3, fluxapyroxad B4, fluopyroxad ( fluopyram B5, flubeneteram B6, sedaxane B7, penthiopyrad B8, boscalid B9, bixafen B10 , Flutolanil B11, furametpyr B12, thifluzamide B13, pydiflumetofen B14, fluindapyr B15, fluindapyr B15 ( fluopimomide) B16, isofetamid B17, inpyrfluxam B18, isoflucypram B19, pyraziflumid B20, pyrapropoyne B21, carboxin B22, oxycarboxin B23, fenfuram B24 , Mepronil B25, benodanil B26, fluopicolide B27, fenamidone B28, famoxa
  • composition is active component A and active component B in a weight ratio of 1:20-20:1;
  • the active component A is one or more of the compounds represented by the general formula I-A or their salts;
  • the salt of the compound represented by the general formula I-A is a salt formed by the compound of the general formula with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;
  • the active component B is selected from benzovindiflupyr B1, penflufen B2, isopyrazam B3, fluxapyroxad B4, fluopyroxad ( fluopyram B5, flubeneteram B6, sedaxane B7, penthiopyrad B8, boscalid B9, bixafen B10 , Flutolanil B11, furametpyr B12, thifluzamide B13, pydiflumetofen B14, fluindapyr B15, fluindapyr B15 ( fluopimomide) B16, isofetamid B17, inpyrfluxam B18, isoflucypram B19, pyraziflumid B20, pyrapropoyne B21, benodanil B26, fluopicolide B27, fenamidone B28 , Famoxadone B29, cyazofamid B30, ametoctradin B31, fluazinam B32
  • composition is active component A and active component B in a weight ratio of 1:10-10:1;
  • the active component A is selected from one or more of the compounds in the general formula I-A or their salts;
  • R 3 is selected from hydrogen, hydroxy, formyl or C 1 -C 4 alkyl;
  • R 4 and R 5 may be the same or different, and are selected from hydrogen, halogen or C 1 -C 4 alkyl;
  • R 6 , R 7 can be the same or different and are selected from hydrogen, halogen or C 1 -C 4 alkyl;
  • R 8 and R 9 can be the same or different and are respectively selected from hydrogen, cyano, halogen or C 1 -C 4 alkyl;
  • R 11 is selected from halogen, hydroxyl, amino, cyano, nitro or C 1 -C 4 alkyl;
  • n is selected from an integer from 0 to 5, when n is 0, there is no substituent on the benzene ring; when n is greater than 1
  • R 11 may be the same or different;
  • R 14 , R 15 , R 16 or R 17 may be the same or different, and are respectively selected from hydrogen, halogen, hydroxyl, amino,
  • the salt of the compound represented by the general formula I-A is a salt formed by the compound of the general formula with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;
  • the active component B is selected from benzovindiflupyr B1, penflufen B2, isopyrazam B3, fluxapyroxad B4, fluopyroxad ( fluopyram B5, flubeneteram B6, sedaxane B7, penthiopyrad B8, boscalid B9, bixafen B10 , Thifluzamide B13, pydiflumetofen B14, fluindapyr B15, fluopimomide B16, inpyrfluxam B18, isoflucypram B19, pyraziflumid B20, pyrapropoyne B21, Benodanil B26, fluopicolide B27, fenamidone B28, famoxadone B29, cyazofamid B30, ametoctradin B31 , Fluazinam B32, fenpicoxamid B33, florylpicoxamid B34, silthiopham B36, flu
  • the composition is the active component A and the active component B in a weight ratio of 1:50-50:1;
  • the active component A is selected from one or more of the compounds in the general formula I-B or their salts;
  • R 6 and R 7 may be the same or different, and are selected from hydrogen, halogen, C 1 -C 4 alkyl, halo C 1 -C 4 alkyl, C 1 -C 4 alkoxy or halo C 1 -C 4 alkoxy;
  • R 8 and R 9 may be the same or different, and are selected from hydrogen, cyano, halogen, C 1 -C 4 alkyl, halogenated C 1 -C 4 alkyl, and C 1 -C 4 Alkoxycarbonyl or halogenated C 1 -C 4 alkoxycarbonyl;
  • R 11 is selected from halogen, hydroxyl, amino, cyano, nitro, C 1 -C 4 alkyl, halogenated C 1 -C 4 alkyl , C 1 -C 4 alkoxy, halogenated C 1 -C 4 alkoxy, C 3 -C 4 cycloalkyl, C 1 -C 4 alkylamino, halogenated C
  • the salt of the compound represented by the general formula IB is a compound of the general formula with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid.
  • Acid salt is a compound of the general formula with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid, methanesulfonic acid, p-toluenesulfonic acid, benzoic acid, phthalic acid or maleic acid.
  • the active component B is selected from benzovindiflupyr B1, penflufen B2, isopyrazam B3, fluxapyroxad B4, fluopyroxad ( fluopyram B5, flubeneteram B6, sedaxane B7, penthiopyrad B8, boscalid B9, bixafen B10 , Flutolanil B11, furametpyr B12, thifluzamide B13, pydiflumetofen B14, fluindapyr B15, fluindapyr B15 ( fluopimomide) B16, isofetamid B17, inpyrfluxam B18, isoflucypram B19, pyraziflumid B20, pyrapropoyne B21, carboxin B22, oxycarboxin B23, fenfuram B24 , Mepronil B25, benodanil B26, fluopicolide B27, fenamidone B28, famoxa
  • composition is active component A and active component B in a weight ratio of 1:20-20:1;
  • the active component A is selected from one or more of the compounds in the general formula I-B or their salts;
  • R 1 is selected from hydrogen, halogen, cyano, nitro, amino, carboxy, C 1 -C 4 alkyl or halo C 1 -C 4 alkyl
  • R 2 is selected from hydrogen, halogen, cyano, Nitro, amino, carboxyl, formyl, C 1 -C 4 alkyl or halo C 1 -C 4 alkyl
  • R 3 is selected from hydrogen, hydroxy, formyl, C 1 -C 4 alkyl, halo C 1 -C 4 alkyl, C 1 -C 4 alkoxy, halogenated C 1 -C 4 alkoxy, C 3 -C 4 cycloalkyl, C 1 -C 4 alkylthio, C 2 -C 4 Alkenylthio, C 2 -C 4 alkenyl, C 2 -C 4 alkynyl, halo C 2 -C 4 alkenyl or halo C 2 -C 4 alkynyl; R 4 and R
  • R 8 and R 9 may be the same or different, and are selected from hydrogen, cyano, halogen, C 1 -C 4 alkyl, halo C 1 -C 4 alkyl, C 1 -C 4 alkoxycarbonyl or halo Substituted C 1 -C 4 alkoxycarbonyl;
  • R 11 is selected from halogen, hydroxyl, amino, cyano, nitro, C 1 -C 4 alkyl, halogenated C 1 -C 4 alkyl, C 1 -C 4 Alkoxy, halogenated C 1 -C 4 alkoxy, C 3 -C 4 cycloalkyl, C 1 -C 4 alkylamino or halogenated C 1 -C 4 alkylamino;
  • n is selected from 0 to 5 When n is 0, there are no substituents on the benzene ring; when n is greater than 1, R 11 may be the same or different;
  • W is selected from hydrogen, halogen
  • the salt of the compound represented by the general formula I-B is a salt formed by the compound of the general formula with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, trifluoroacetic acid, oxalic acid or methanesulfonic acid;
  • the active component B is selected from benzovindiflupyr B1, penflufen B2, isopyrazam B3, fluxapyroxad B4, fluopyroxad ( fluopyram B5, flubeneteram B6, sedaxane B7, penthiopyrad B8, boscalid B9, bixafen B10 , Flutolanil B11, furametpyr B12, thifluzamide B13, pydiflumetofen B14, fluindapyr B15, fluindapyr B15 ( fluopimomide) B16, isofetamid B17, inpyrfluxam B18, isoflucypram B19, pyraziflumid B20, pyrapropoyne B21, benodanil B26, fluopicolide B27, fenamidone B28 , Famoxadone B29, cyazofamid B30, ametoctradin B31, fluazinam B32
  • composition is active component A and active component B in a weight ratio of 1:10-10:1;
  • the active component A is selected from one or more of the compounds in the general formula I-B or their salts;
  • R 1 is selected from hydrogen, halogen, cyano, nitro, amino, carboxy or C 1 -C 4 alkyl
  • R 2 is selected from hydrogen, halogen, cyano, nitro, amino, carboxy, formyl or C 1 -C 4 alkyl
  • R 3 is selected from hydrogen, hydroxy, formyl or C 1 -C 4 alkyl
  • R 4 and R 5 may be the same or different, and are respectively selected from hydrogen, halogen or C 1 -C 4 alkane
  • R 6 and R 7 may be the same or different, and are each selected from hydrogen, halogen or C 1 -C 4 alkyl
  • R 8 and R 9 may be the same or different, and are respectively selected from hydrogen, cyano, halogen or C 1- C 4 alkyl
  • R 11 is selected from halogen, hydroxy, amino, cyano, nitro or C 1 -C 4 alkyl
  • n is selected from an integer of 0 to 5, when n is 0, there is no substitu
  • the salt of the compound represented by the general formula I-B is a salt formed by the compound of the general formula with hydrochloric acid, sulfuric acid, phosphoric acid, formic acid or acetic acid;
  • the active component B is selected from benzovindiflupyr B1, penflufen B2, isopyrazam B3, fluxapyroxad B4, fluopyroxad ( fluopyram B5, flubeneteram B6, sedaxane B7, penthiopyrad B8, boscalid B9, bixafen B10 , Thifluzamide B13, pydiflumetofen B14, fluindapyr B15, fluopimomide B16, inpyrfluxam B18, isoflucypram B19, pyraziflumid B20, pyrapropoyne B21, Benodanil B26, fluopicolide B27, fenamidone B28, famoxadone B29, cyazofamid B30, ametoctradin B31 , Fluazinam B32, fenpicoxamid B33, florylpicoxamid B34, silthiopham B36, flu
  • An application of a bactericidal composition which is used to prepare a medicine for preventing and treating plant pathogenic fungi and bacterial diseases
  • the plant pathogenic fungi and bacterial diseases are plant powdery mildew, rust, scab, leaf mold, sheath blight, wilt, mole, smut, smut, downy mildew, and late blight , Blight, downy blight, black shank, cotton rot, damping-off, cotton blight, white rust, black spot, leaf spot, early blight, anthracnose, brown spot, vine blight, gray mold Disease, sclerotinia, rot, root rot, head blight, soft rot, bacterial leaf blight, leaf blight, angular leaf spot, round spot, bacterial leaf blight, bacterial wilt, canker or Huanglong disease.
  • a bactericidal preparation the effective ingredient of the preparation is the bactericidal composition, and the weight percentage of the bactericidal composition is 0.1-95%.
  • the concentration of the composition of the present invention is 5-500mg/L (active ingredient content, the same below) in the crop planting area, preferably 50-200mg/L.
  • the active component A and at least one active component B in the composition of the present invention are pre-prepared according to the appropriate ratio provided by the present invention or prepared on site or the two components are used separately and sequentially.
  • composition of the present invention is suitable for use in trees (apple, rubber, pear, citrus, hawthorn, chestnut, Chinese pepper, wolfberry, mango, papaya, lychee, banana, peach, etc.), vine plants (grapes, etc.), melons and vegetables (tomatoes, etc.) , Eggplant, pepper, cucumber, melon, wax gourd, watermelon, pumpkin, bitter gourd, loofah, chayote, gourd, zucchini, lettuce, potato, carrot), legumes (pea, kidney bean, cowpea), cereals (wheat, rice, Corn, sorghum, etc.), oil crops (canola, soybeans, peanuts, sesame, etc.), onions and garlic (onions, garlic, onions), cash crops (tobacco, etc.), fungi, bacterial disease control of flower plants and lawns, and seeds Processing, fruit preservation and other applications.
  • the bactericidal composition of the present invention is particularly suitable for the prevention and treatment of the following plant diseases: apple tree powdery mildew, rubber tree powdery mildew, citrus powdery mildew, hawthorn powdery mildew, chestnut powdery mildew, pepper powdery mildew, wolfberry powdery mildew, mango powdery mildew, papaya powdery mildew, sticks Powdery mildew, grape powdery mildew, tomato powdery mildew, eggplant powdery mildew, pepper powdery mildew, cucumber powdery mildew, melon powdery mildew, wax gourd powdery mildew, watermelon powdery mildew, pumpkin powdery mildew, bitter melon powdery mildew, loofah powdery mildew, chayote powdery mildew Disease, squash powdery mildew, zucchini powdery mildew, lettuce powdery mildew, pea powdery mildew, bean powdery mildew, wheat powdery mildew, barley powder
  • the active component A and the bactericide active component B are combined in different proportions, and the "observation effect" is greater than the "calculated effect", the synergistic effect is very obvious, the dosage of the medicine can be reduced, and the environmental pollution can be reduced.
  • the invention selects fungicides with different action mechanisms to be mixed, which helps delay pathogenic bacteria to develop resistance, provides an effective solution to the problem of fungicide resistance faced by agricultural production and the pesticide industry, and prolongs the service life of the medicament.
  • the synergistic effect of the composition of the present invention on harmful fungi and bacterial diseases can be further illustrated by the following examples, but the present invention is by no means limited to this.
  • the active components are the compound A and the bactericide B in the bactericidal composition of the present invention;
  • the fungicide B is selected from the group consisting of respiratory inhibitor fungicides, nucleic acid metabolism inhibitor fungicides, cell wall synthesis inhibitor fungicides, signal transduction inhibitor fungicides, cytoskeleton and Sports protein inhibitor fungicides, sterol biosynthesis inhibitor fungicides, phospholipid synthesis inhibitor fungicides, cell wall synthesis inhibitor fungicides, methionine biosynthesis inhibitor fungicides, multi-site inhibition One or more of the type of fungicides and fungicides with unknown mechanism of action.
  • test method and evaluation method are as follows:
  • the active samples to be tested are the combination of active component A, active component B, active component A and active component B respectively.
  • the active component A is one or more of active component A1, active component A2, active component A3 and active component A4;
  • the active component A1 is the compound A1 represented by the general formula I-A;
  • Active component A2 is a salt formed by compound A1 and sulfuric acid
  • R 3 is selected from hydrogen
  • R 4 and R 5 are each selected from hydrogen
  • R 6 and R 7 are each selected from hydrogen
  • R 8 and R 9 are each selected from hydrogen
  • R 11 is selected from 4-chloro
  • W is selected from hydrogen, that is, compound A1;
  • Active component A3 is compound A3 represented by general formula I-B;
  • the active component A4 is a salt formed by compound A3 and sulfuric acid:
  • R 3 is selected from hydrogen
  • R 4 and R 5 are each selected from hydrogen
  • R 6 and R 7 are each selected from hydrogen
  • R 8 and R 9 are each selected from hydrogen
  • R 11 is selected from 4-chloro
  • n 1
  • R 14 , R 15 , R 16 or R 17 are each selected from hydrogen
  • W is selected from hydrogen, that is, compound A3.
  • the active component B is benzodifluconazole B1, fluconazole B4, fluopyram B5, boscalid B9, thiafluzamide B13, fluconazole hydroxylamine B14, fluopyram B27, azole Azoxystrobin B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimethomorph B42, dipropargyl B43, Benoxystrobin B44, methoxamyl B46, ethoxyfensulfonate B56 , Ethiprofen B58, Fludioxonil B65, Ethomycarb B73, Benzoconazole B74, Cyclofenac B78, Clofluconazole B91, Prochloraz B95, Fluoxamol B116, fluoxapiproline B117, more Antimycin B124, Kasugamycin B129, Mancozeb B134, Mancozeb B135, Mancozeb B136, Prosenzin
  • the composition to be tested is the active component A1, each active component B, active component A1, and each active component B; among them, the active component B is benzoenfluconazole B1, fluconazole B4, fluorine Pyraclostrobin B5, Boscalid B9, Thiofuramid B13, Fluconidal Hydroxylamide B14, Fluopyram B27, Pyraclostrobin B31, Fluazinam B32, fenpicoxamid B33, Flumorph B41, Dienoyl Morpholine B42, Dipropargyl B43, Benzoamide B44, Metalaxyl B46, Ethidium Sulfonate B56, Ethiprofen B58, Fludioxonil B65, Ethimeprocarb B73, Benzophenone B74 , Cyanoxystrobin B78, Cloflufenazone B91, Prochloraz B95, Fluoxapiproline B116, Fluoxapiproline B117, Polyoxin B124,
  • composition to be tested is the active component A2 and/or with benzodifluconazole B1, fluconazole B4, fluopyram B5, boscalid B9, thiafluzamide B13, fluconazole amide B14, fluopyram B27, pyraclostrobin B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimethomorph B42, dipropysmid B43, benzfluramide B44, methoxamyl B46, ethoxylated sulfonate B56, ethoxylate B58, fludioxonil B65, dimethocarb B73, benzoxanone B74, cyanostrobin B78, clofluconazole B91, prochloraz B95, fluthiazole Picophenone B116, fluoxapiproline B117, polyoxin B124, kasugamycin B129, mancozeb B134, mancozeb
  • composition to be tested is the active component A3 and/or with benzodifluconazole B1, fluconazole B4, fluopyram B5, boscalid B9, thiafluzamide B13, and fluconazole amide B14, fluopyram B27, pyraclostrobin B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimethomorph B42, dipropysmid B43, benzfluramide B44, methoxamid B46, ethoxylated sulfonate B56, ethoxylate B58, fludioxonil B65, dimethocarb B73, benzoxanone B74, cyanostrobin B78, clofluconazole B91, prochloraz B95, fluthiazole Picophenone B116, fluoxapiproline B117, polyoxin B124, kasugamycin B129, mancozeb B134, mancozeb
  • composition to be tested is the active component A4 and/or with benzodifluconazole B1, fluconazole B4, fluopyram B5, boscalid B9, thiafluzamide B13, and fluconazole amide B14, fluopyram B27, pyraclostrobin B31, fluazinam B32, fenpicoxamid B33, flumorph B41, dimethomorph B42, dipropysmid B43, benzfluramide B44, methoxamid B46, ethoxylated sulfonate B56, ethoxylate B58, fludioxonil B65, dimethocarb B73, benzoxanone B74, cyanostrobin B78, clofluconazole B91, prochloraz B95, fluthiazole Picophenone B116, fluoxapiproline B117, polyoxin B124, kasugamycin B129, mancozeb B134, mancozeb
  • the disease After the disease is infected, they are moved into the greenhouse for cultivation; the diseased plants that do not need moisturizing culture are inoculated and directly moved into the greenhouse for cultivation. After the control is fully onset, the disease condition is investigated, and the total number of leaves, the number of diseased leaves and the number of disease grades under investigation are recorded.
  • Grade 0 The whole plant is disease-free
  • Grade 1 The area of the diseased spot is less than 5% of the entire leaf area
  • Grade 3 Disease spot area is 6-10% of the entire leaf area
  • Grade 5 The area of diseased spots is 11-20% of the entire leaf area
  • Grade 7 diseased spot area points 21-50% of the entire leaf area
  • Grade 9 The diseased spot area is more than 51% of the entire leaf area.
  • An efficacy of "0" indicates that the infection level of the treated crop is the same as that of the untreated control crop; an efficacy of "100" indicates that the treated crop is not infected.
  • C exp The expected efficacy (C exp ) of the composition is determined using the Abbott method (see Liu Xuemin et al., Synergism of Fungicide Mixing, Pesticide Science and Management, 2002, 23(5), 12-15).
  • Y The effectiveness of the active ingredient B when the concentration is b.
  • the synergy of the composition is evaluated by the ratio of the observed efficacy (C obs ) and the expected efficacy (C exp ).
  • C obs the observed efficacy
  • C exp the expected efficacy
  • the potted two-leaf cucumber seedlings of the variety "Jinyan-4" were sprayed with the aqueous solutions of the active ingredients or compositions (the active ingredient concentration is described in the table below), and after 24 hours, the spores of the yellow powdery mildew fungus were treated with an adapter Spray on the leaves and cultivate in the greenhouse. After 10 days, the disease will be investigated after the control has fully developed disease.
  • the potted two-leaf cucumber seedlings of the variety "Xin Tai Mi Ci” were sprayed with the aqueous solution of each active ingredient or composition (the active ingredient concentration is described in the table below). After 24 hours, the spores of the yellow powdery mildew fungus were treated with an adapter Spray on the leaves and cultivate in the greenhouse. After 10 days, the disease will be investigated after the control has fully developed disease.
  • Table 5 shows the activity data of the individual active components of the present invention for preventing and curing melon powdery mildew.
  • Table 6 shows the activity data and synergistic effect of the composition of the present invention in preventing and curing melon powdery mildew.
  • the potted six-leaf pepper seedlings of "green bell pepper” were sprayed with the aqueous solutions of each active ingredient or composition (the active ingredient concentration is described in the table below). After 24 hours, the spores of Capsicum powdery mildew were inoculated on the back of the leaves. , And cultivated in the climate room, after the disease is infected, moved to the greenhouse for cultivation, 20-25 days later, after the control has fully developed disease, the disease condition will be investigated.
  • the two-leaf stage kidney bean seedlings in pots with the variety "Fengshou No. 1" were sprayed with the aqueous solutions of the active ingredients or compositions (the active ingredient concentration is described in the table below), and dried naturally after spraying. After 24 hours, the bean powder An aqueous suspension of pathogenic bacteria spores (5 ⁇ 10 6 /ml) was inoculated on kidney bean leaves, dried naturally, and then moved to a greenhouse for cultivation. The culture conditions (temperature: 23-28°C in day, 18-20°C at night), wait for control Investigate the condition after fully onset.
  • Table 11 shows the activity data of each individual active component of the present invention for preventing and controlling powdery mildew of kidney bean.
  • Table 12 shows the activity data and synergistic effect of the composition of the present invention for preventing and controlling powdery mildew of kidney bean.
  • the potted six-leaf tobacco seedlings of the variety "CN89" were sprayed with the aqueous solutions (concentrations described in the table below) of each active component or composition. After 24 hours, the tobacco powdery mildew spore suspension was inoculated on the tobacco seedling leaves , Directly transferred to the greenhouse for cultivation, 20 days later, the disease condition investigation will be carried out after the control has fully developed the disease.
  • Table 13 shows the activity data of the individual active components of the present invention for preventing and treating tobacco powdery mildew.
  • Table 14 shows the activity data and synergistic effect of the composition of the present invention in preventing and treating tobacco powdery mildew.
  • Example 7 Experiments on the prevention and control of corn rust
  • the potted two-leaf corn seedlings of "Golden Waxy” were sprayed with the aqueous solution of each active component or composition (the active ingredient concentration is described in the table below). After 24 hours, the corn rust fungus spore suspension was inoculated on the corn On the leaves, and cultivated in a climate chamber, after the disease is infected, moved to the greenhouse for cultivation, 7 days later, after the control has fully developed disease, the disease condition will be investigated.
  • Table 15 shows the activity data of each individual active component of the present invention for preventing and controlling corn rust.
  • Table 16 shows the activity data and synergistic effect of the composition of the present invention for preventing and controlling corn rust.
  • the potted two-leaf cucumber seedlings of the variety "Xin Tai Mi Ci” were sprayed with the aqueous solution of each active ingredient or composition (the active ingredient concentration is described in the table below), and 24 hours later, the sporangia of the pathogen of cucumber downy mildew
  • the suspension was inoculated on cucumber leaves and cultivated in a climate chamber. After the disease was infected, it was moved to the greenhouse for cultivation. After 7 days, the disease was investigated after the control had fully developed disease.
  • Table 17 shows the activity data of each individual active component of the present invention for preventing and controlling cucumber downy mildew.
  • Table 18 shows the activity data and synergistic effect of the composition of the present invention for preventing and controlling cucumber downy mildew.
  • the potted two-leaf cucumber seedlings of the variety "Xin Tai Mi Ci” were sprayed with the aqueous solution of each active ingredient or composition (the active ingredient concentration is described in the table below), and 24 hours later, the sporangia of the pathogen of cucumber downy mildew
  • the suspension was inoculated on cucumber leaves and cultivated in a climate chamber. After the disease was infected, it was moved to the greenhouse for cultivation. After 7 days, the disease was investigated after the control had fully developed disease.
  • Table 19 shows the activity data of each individual active component of the present invention against cucumber downy mildew.
  • Table 20 shows the activity data and synergistic effect of the composition of the present invention in preventing and treating cucumber downy mildew.
  • the test was carried out with reference to the national standard GB/T 17980.26-2000: Guidelines for Pesticide Field Efficacy Tests (1)-Fungicides to control cucumber downy mildew
  • the test site was set up in the protected area of Bayi Town, Sujiatun District, Shenyang City.
  • the cucumber variety was Xintaimi thorn.
  • the management level was at the level of management.
  • the plot area was about 25m 2 ;
  • According to the test set dose the cucumber was sprayed with pesticide; the test was applied 2 times, the interval of application was 7 days, and the incidence of cucumber downy mildew in each plot was investigated 10 days after the second application. Samples were taken at 4 points in each subdivision, and 8 plants were taken from each point, and each plant was investigated from top to bottom for the disease of the whole plant's leaves.
  • Table 21 shows the activity data of each individual active component of the present invention for controlling cucumber downy mildew.
  • Table 22 shows the activity data and synergistic effect of the composition of the present invention for preventing and controlling cucumber downy mildew.
  • the potted two-leaf cucumber seedlings of the variety "Xin Tai Mi Ci” were sprayed with the aqueous solution of each active ingredient or composition (the active ingredient concentration is described in the table below), and 24 hours later, the sporangia of the pathogen of cucumber downy mildew
  • the suspension was inoculated on cucumber leaves and cultivated in a climate chamber. After the disease was infected, it was moved to the greenhouse for cultivation. After 7 days, the disease was investigated after the control had fully developed disease.
  • Table 23 shows the activity data of each individual active component of the present invention for controlling cucumber downy mildew.
  • Table 24 shows the activity data and synergistic effect of the composition of the present invention for preventing and controlling cucumber downy mildew.
  • the potted five-leaf grape seedlings of "Seedless White Chicken Heart” were sprayed with the aqueous solution of each active component or composition (the active ingredient concentration is described in the table below). After 24 hours, the sporangia of the pathogen of grape downy mildew were removed. The suspension was inoculated on grape leaves, and the grape seedlings were placed in a climate room for cultivation. After the disease was infected, it was moved to the greenhouse for cultivation. After 7 days, the disease was investigated after the control had fully developed the disease.
  • Table 25 shows the activity data of the individual active components of the present invention against grape downy mildew.
  • Table 26 shows the activity data and synergistic effect of the composition of the present invention in preventing and controlling grape downy mildew.
  • the potted five-leaf grape seedlings of "Seedless White Chicken Heart” were sprayed with the aqueous solution of each active component or composition (the active ingredient concentration is described in the table below). After 24 hours, the sporangia of the pathogen of grape downy mildew were removed. The suspension was inoculated on grape leaves, and the grape seedlings were placed in a climate room for cultivation. After the disease was infected, it was moved to the greenhouse for cultivation. After 7 days, the disease was investigated after the control had fully developed the disease.
  • Table 27 shows the activity data of the individual active components of the present invention against grape downy mildew.
  • Table 28 shows the activity data and synergistic effect of the composition of the present invention in preventing and treating grape downy mildew.
  • the potted five-leaf grape seedlings of "Seedless White Chicken Heart” were sprayed with the aqueous solution of each active component or composition (the active ingredient concentration is described in the table below). After 24 hours, the sporangia of the pathogen of grape downy mildew were removed. The suspension was inoculated on grape leaves, and the grape seedlings were placed in a climate room for cultivation. After the disease was infected, it was moved to the greenhouse for cultivation. After 7 days, the disease was investigated after the control had fully developed the disease.
  • Table 29 shows the activity data of the individual active components of the present invention against grape downy mildew.
  • Table 30 shows the activity data and synergistic effect of the composition of the present invention in preventing and treating grape downy mildew.
  • the potted five-leaf grape seedlings of "Seedless White Chicken Heart” were sprayed with the aqueous solution of each active component or composition (the active ingredient concentration is described in the table below). After 24 hours, the sporangia of the pathogen of grape downy mildew were removed. The suspension was inoculated on grape leaves, and the grape seedlings were placed in a climate room for cultivation. After the disease was infected, it was moved to the greenhouse for cultivation. After 7 days, the disease was investigated after the control had fully developed the disease.
  • Table 31 shows the activity data of the individual active components of the present invention against grape downy mildew.
  • Table 32 shows the activity data and synergistic effect of the composition of the present invention in preventing and controlling grape downy mildew.
  • the potted five-leaf cabbage seedlings of the variety "Four Seasons Chinese Cabbage” were sprayed with the aqueous solutions of the active ingredients or compositions (the active ingredient concentration is described in the table below). After 24 hours, the spores of Downy mildew of cabbage were inoculated in The back of the leaves were cultivated in a climate room. After the disease was infected, it was moved to the greenhouse for cultivation. After 5-7 days, the disease was investigated after the control had fully developed disease.
  • Table 33 shows the activity data of each individual active component of the present invention for controlling downy mildew of cabbage.
  • Table 34 shows the activity data and synergistic effect of the composition of the present invention for preventing and treating downy mildew of cabbage.
  • Table 35 shows the activity data of each individual active component of the present invention for controlling sunflower downy mildew.
  • Table 36 shows the activity data and synergistic effect of the composition of the present invention in preventing and controlling sunflower downy mildew.
  • the potted five-leaf tomato seedlings of "Fen Tai Yin” were sprayed with the aqueous solution of each active ingredient or composition (the active ingredient concentration is as described in the table below). After 24 hours, the sporangia suspension of the tomato late blight pathogen Inoculate the tomato leaves and place the tomato seedlings in a climatic room for cultivation. After the disease is infested, move to the greenhouse for cultivation. After 7 days, the disease will be investigated after the control has fully developed the disease.
  • Table 37 shows the activity data of each individual active component of the present invention for controlling tomato late blight.
  • Table 38 shows the activity data and synergistic effect of the composition of the present invention in preventing and curing tomato late blight.
  • the potted five-leaf tomato seedlings of "Fen Tai Yin” were sprayed with the aqueous solution of each active ingredient or composition (the active ingredient concentration is described in the table below).
  • the sporangia suspension of the tomato late blight pathogen Inoculate the tomato leaves and place the tomato seedlings in a climatic room for cultivation. After the disease is infested, move to the greenhouse for cultivation. After 7 days, the disease will be investigated after the control has fully developed the disease.
  • Table 39 shows the activity data of each individual active component of the present invention for controlling tomato late blight.
  • Table 40 shows the activity data and synergistic effect of the composition of the present invention in preventing and curing tomato late blight.
  • the potted two-leaf cucumber seedlings of "Xin Tai Mi Ci” were sprayed with the aqueous solution of each active component or composition, and dried naturally after spraying. After 24 hours, the cucumber anthracnose pathogen spore suspension was inoculated in Cucumber leaves and cultivated in a climate chamber. After the disease is infected, move to the greenhouse for cultivation. After 7 days, the disease will be investigated. The leaves will be graded according to the development degree of pathogen infection on the leaves, and the total number of leaves and diseased leaves will be recorded. According to the formula to calculate the efficacy of the medicine.
  • Table 41 shows the activity data of each individual active component of the present invention for preventing and controlling cucumber anthracnose.
  • Table 42 shows the activity data and synergistic effect of the composition of the present invention for preventing and controlling cucumber anthracnose.
  • the potted two-leaf cucumber seedlings of "Xin Tai Mi Ci” were sprayed with an aqueous solution of each active component or composition, and dried naturally after spraying. After 24 hours, an aqueous suspension of cucumber anthracnose pathogen spores was inoculated in Cucumber leaves and cultivated in a climate chamber. After the disease is infected, move to the greenhouse for cultivation. After 7 days, the disease will be investigated. The leaves will be graded according to the development degree of pathogen infection on the leaves, and the total number of leaves and diseased leaves will be recorded. According to the formula to calculate the efficacy of the medicine.
  • Table 43 shows the activity data of each individual active component of the present invention for preventing and controlling cucumber anthracnose.
  • Table 44 shows the activity data and synergistic effect of the composition of the present invention for preventing and controlling cucumber anthracnose.
  • the potted six-leaf pepper seedlings of the variety "green bell pepper” were sprayed with the aqueous solutions of the active ingredients or compositions (the active ingredient concentration is described in the table below). After 24 hours, the pepper anthracnose pathogen spore suspension was inoculated in The back of the leaves were cultivated in a climate room. After the disease was infected, it was moved to the greenhouse for cultivation. After 5-7 days, the disease was investigated after the control had fully developed disease.
  • Table 45 shows the activity data of each individual active component of the present invention for preventing and controlling pepper anthracnose.
  • Table 46 shows the activity data and synergistic effect of the composition of the present invention in preventing and treating pepper anthracnose.
  • the potted five-leaf eggplant seedlings of the variety "Liaoqie No. 1" were sprayed with the aqueous solutions of the active components or compositions (concentrations as described in the table below). After 24 hours, the spore suspension of the brown spot disease fungus was inoculated in Eggplant leaves and cultivated in a climate chamber. After the disease is infested, it is moved to the greenhouse for cultivation. After 10 days, the disease is investigated after the control has fully developed disease.
  • Table 47 shows the activity data of each individual active component of the present invention for preventing and curing eggplant brown spot.
  • Table 48 shows the activity data and synergistic effect of the composition of the present invention in preventing and treating eggplant brown spot disease.
  • the potted five-leaf eggplant seedlings of the variety "Liaoqie No. 1" were sprayed with the aqueous solutions of the active components or compositions (concentrations as described in the table below). After 24 hours, the spore suspension of Corynespora aubergii Inoculated on eggplant leaves and cultivated in a climate room. After the disease is infested, it is moved to the greenhouse for cultivation. After 8 days, the disease is investigated after the control has fully developed disease.
  • Table 49 shows the activity data of the individual active components of the present invention for preventing and controlling Corynespora leaf spot of eggplant.
  • Table 50 shows the activity data and the synergistic effect of the composition of the present invention in preventing and treating Corynespora leaf spot of eggplant.
  • Table 52 shows the activity data and synergistic effect of the composition of the present invention in preventing and treating pear black spot disease.
  • Table 53 shows the activity data of each individual active component of the present invention for preventing and curing peanut leaf spot.
  • Table 54 shows the activity data and synergistic effect of the composition of the present invention in preventing and treating peanut leaf spot.
  • Table 55 shows the activity data of each individual active component of the present invention for preventing and curing peanut leaf spot.
  • Table 56 shows the activity data and synergistic effect of the composition of the present invention in preventing and treating peanut leaf spot.
  • the potted two-leaf wheat seedlings of "Liaochun 18" were sprayed with the aqueous solutions (concentrations as described in the table below) of each active component or composition. After 24 hours, the spore suspension of Fusarium graminearum was inoculated on the leaves And cultivated in the greenhouse. After 5 days, the disease condition investigation will be carried out after the control has fully developed the disease.
  • Table 58 shows the activity data and synergistic effect of the composition of the present invention for preventing and controlling wheat head blight.
  • the potted two-leaf rice seedlings of the variety "Longdao 18" were sprayed with the aqueous solutions (concentrations as described in the table below) of each active component or composition. After 24 hours, the rice sheath blight fungus hypha suspension was inoculated Cultivate them on rice leaves and in a greenhouse. After 5 days, the disease will be investigated after the control has fully developed disease.
  • Table 59 shows the activity data of each individual active component of the present invention for controlling rice sheath blight.
  • Table 60 shows the activity data and synergistic effect of the composition of the present invention for preventing and controlling rice sheath blight.
  • the potted two-leaf rice seedlings of the variety "Longdao 18" were sprayed with the aqueous solutions (concentrations as described in the table below) of each active component or composition. After 24 hours, the rice sheath blight fungus hypha suspension was inoculated Cultivate them on rice leaves and in a greenhouse. After 5 days, the disease will be investigated after the control has fully developed disease.
  • Table 61 shows the activity data of each individual active component of the present invention for controlling rice sheath blight.
  • Table 62 shows the activity data and synergistic effect of the composition of the present invention for preventing and curing rice sheath blight.
  • the rice bacterial blight strains were sprayed evenly on the rice leaves, kept in artificial air for 24 hours, and then moved to the greenhouse to continue cultivation. After the clear water control is fully onset, the length of the diseased spots on the leaves of each treatment is measured, and the disease inhibition rate is calculated by the following formula, which is the observation effect.
  • Table 63 shows the activity data of each individual active component of the present invention for controlling rice bacterial blight.
  • Table 64 shows the activity data and synergistic effect of the composition of the present invention for preventing and curing rice bacterial blight.
  • Potted six-leaf pepper seedlings of "green bell pepper” were inoculated with the spore suspension of Capsicum anthracnose and cultivated in a climate chamber. After 24 hours, the active ingredients or compositions were used in aqueous solutions (the concentration of active ingredients is shown in the table below). Said) spray treatment, and then moved to the greenhouse for cultivation, 5-7 days later, after the control has fully developed disease, the disease condition will be investigated.
  • Example 33 Test on the persistence of preventing and controlling powdery mildew of pepper
  • the potted six-leaf pepper seedlings of the variety "green bell pepper” were sprayed with the aqueous solutions of the active ingredients or compositions (the active ingredient concentration is described in the table below) for 1 day, 3 days, 5 days, and 7 days. After 10 days, the spores of Capsicum powdery mildew fungus were sprayed on the back of the leaves with an inoculator, and cultured in a greenhouse. After 20-25 days, the disease was investigated after the control had fully developed the disease.
  • Table 67 shows the activity data of each individual active component and the composition of the present invention for preventing and controlling powdery mildew of pepper.
  • Table 68 shows the activity data of each individual active component of the present invention for preventing and curing cucumber powdery mildew.
  • Table 69 shows the activity data and synergistic effect of the composition of the present invention in preventing and curing cucumber powdery mildew.

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Abstract

本发明属于农用杀菌剂领域，具体的说是一种杀菌组合物及其应用。组合物为A、B两种活性组分，活性组分A和活性组分B之间的重量比为1:99-99:1；活性组分A为含嘧啶的取代吡唑类化合物或其盐中的一种或几种，活性组分B选自一种杀菌剂。本发明杀菌组合物特别适合防治多种植物病原性真菌、细菌病害。

Description

杀菌组合物及其应用 技术领域
本发明属于农用杀菌剂领域，具体涉及一种含嘧啶的取代吡唑类化合物与一种杀菌剂的杀菌组合物及其应用。
背景技术
专利WO2016184378公开了一种含嘧啶的取代吡唑类化合物及其用途,其中报道了如下通式I-A、I-B所示的化合物对多种病害具有良好的活性。
Figure PCTCN2020130513-appb-000001
呼吸抑制剂类杀菌剂、核酸代谢抑制剂类杀菌剂、细胞壁合成抑制剂类杀菌剂、信号传导作用抑制剂类杀菌剂、细胞骨架和运动蛋白抑制剂类杀菌剂、固醇生物合成抑制剂类杀菌剂、磷脂合成抑制剂类杀菌剂、细胞壁合成抑制剂类杀菌剂、甲硫氨酸生物合成抑制剂类杀菌剂是农业生产中广泛使用且防治效果突出的杀菌剂。因其作用位点单一，长期重复使用后，部分品种的田间药效显著下降。多位点抑制剂类杀菌剂是一类广谱的保护性杀菌剂，但该类杀菌剂治疗活性差，田间用量大。
在杀菌剂应用的实践中，人们经常发现一种药剂在初期具有很好的防病效果，但随着使用次数增多，用药量也逐渐加大，而药效提高甚微，有时甚至是完全失去了防病作用。其主要原因在于病原菌种群发生了变化，即部分病原菌通过突变获得了耐药质粒而产生抗药性，并在自然选择中逐步形成优势种群，导致了杀菌剂的药效降低。同时，人们也认识到，农药施用后，一部分会散落在土壤上或散逸到空气中，或随雨水及农田排水流入河、湖中，造成环境污染。为此，人们迫切需要药效高，用量小，环境污染少，并能延缓病原菌抗药性的农药产品。
农药组合应用是延缓病原菌产生抗药性的重要手段，也是减小农 药用量有效方法。杀菌剂组合应用的科学性不但取决于防治对象、作用机理，也取决于药剂混用后联合作用性质。因此，开发一种作用互补、增效性显著的高效杀菌剂组合物存在着多种制约因素，成功率极低。
发明内容
本发明目的在于提供一种含嘧啶的取代吡唑类化合物与一种杀菌剂的增效性杀菌组合物及其用途。
为实现上述目的，本发明采用技术方案为：
一种杀菌组合物，组合物为A、B两种活性组分，活性组分A和活性组分B之间的重量比为1:99-99:1；
其中，活性组分A为含嘧啶的取代吡唑类化合物或其盐中的一种或几种；活性组分B选自一种杀菌剂。
活性组分A为通式I-A或I-B所示的化合物或其盐：
Figure PCTCN2020130513-appb-000002
式中：
R 1选自氢、卤素、氰基、硝基、氨基、羧基、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 1-C 4烷硫基、卤代C 1-C 4烷硫基、C 1-C 4烷基亚磺酰基、C 1-C 4烷基磺酰基、C 2-C 4烯基、卤代C 2-C 4烯基、C 2-C 4炔基、卤代C 2-C 4炔基、C 3-C 4烯氧基、卤代C 3-C 4烯氧基、C 3-C 4炔氧基、卤代C 3-C 4炔氧基、C 1-C 4烷基氨基、二(C 1-C 4烷基)氨基、C 1-C 4烷基氨基羰基、卤代C 1-C 4烷基氨基羰基、C 1-C 4烷氧基羰基、卤代C 1-C 4烷氧基羰基、C 1-C 4烷氧基C 1-C 4烷基或C 1-C 4烷硫基C 1-C 4烷基；
R 2选自氢、卤素、氰基、硝基、氨基、羧基、甲酰基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；
R 3选自氢、羟基、甲酰基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷硫基、C 2-C 4烯基 硫基、C 2-C 4烯基、C 2-C 4炔基、卤代C 2-C 4烯基、卤代C 2-C 4炔基、C 1-C 4烷氧基C 1-C 4烷基、卤代C 1-C 4烷氧基C 1-C 4烷基、C 1-C 4烷硫基C 1-C 4烷基、卤代C 1-C 4烷硫基C 1-C 4烷基、C 1-C 4烷基亚磺酰基、卤代C 1-C 4烷基亚磺酰基、C 1-C 4烷基磺酰基、卤代C 1-C 4烷基磺酰基、C 1-C 4烷基氨基磺酰基、二(C 1-C 4烷基)氨基磺酰基、C 1-C 4烷基磺酰基氨基羰基、C 1-C 4烷基羰基氨基磺酰基、C 3-C 4环烷基氧基羰基、C 1-C 4烷基羰基、卤代C 1-C 4烷基羰基、C 1-C 4烷氧基羰基、卤代C 1-C 4烷氧基羰基、C 1-C 4烷基羰基C 1-C 4烷基、C 1-C 4烷氧基羰基C 1-C 4烷基、C 1-C 4烷基氨基羰基、二(C 1-C 4烷基)氨基羰基、C 2-C 4烯氧基羰基、C 2-C 4炔氧基羰基、C 1-C 4烷氧基C 1-C 4烷氧基羰基、C 1-C 4烷基氨基硫基、二(C 1-C 4烷基)氨基硫基、芳基羰基C 1-C 4烷基、芳基羰基、芳氧基羰基、芳基C 1-C 4烷基氧基羰基、芳基C 1-C 4烷基、杂芳基羰基C 1-C 4烷基、杂芳基羰基、杂芳氧基羰基、杂芳基C 1-C 4烷基氧基羰基或杂芳基C 1-C 4烷基；
R 4、R 5可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；其中，R 4、R 5与其相连的C还可组成C 3-C 4的环；
R 6、R 7可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；其中，R 6、R 7与其相连的C还可组成C 3-C 4的环；
R 8、R 9可相同或不同，分别选自氢、氰基、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基羰基、卤代C 1-C 4烷氧基羰基、未取代的或被1-5个R 11取代的芳基、芳甲基、芳基羰基、芳甲基羰基、芳氧基羰基、杂芳基、杂芳甲基、杂芳基羰基、杂芳甲基羰基或杂芳氧基羰基；
R 11选自卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷基氨基、卤代C 1-C 4烷基氨基、二(C 1-C 4烷基)氨基、卤代二(C 1-C 4烷基)氨基、C 1-C 4烷硫基、卤代C 1-C 4烷硫基、C 2-C 4烯基、C 2-C 4炔基、C 2-C 4烯氧基、卤代C 2-C 4烯氧基、C 2-C 4炔氧基、卤代C 2-C 4炔氧基、C 1-C 4烷基磺酰基、卤代C 1-C 4烷基磺酰基、C 1-C 4烷基羰基、卤代C 1-C 4烷基羰基、C 1-C 4烷氧基羰基、卤代C 1-C 4烷氧基羰基、C 1-C 4烷氧基C 1-C 4烷基、卤代C 1-C 4烷氧基C 1-C 4烷基、C 1-C 4烷硫基C 1-C 4烷基、卤代C 1-C 4烷硫基C 1-C 4烷基、C 1-C 4烷氧基羰基C 1-C 4烷基、卤代C 1-C 4烷氧基羰基C 1-C 4烷基、C 1-C 4烷硫基羰基C 1-C 4烷基、卤代C 1-C 4烷硫基羰基C 1-C 4烷基、C 1-C 4烷基羰基氧基、卤代C 1-C 4烷基羰基氧基、C 1-C 4烷氧基羰基氧基、卤代C 1-C 4烷氧基羰基氧基、C 1-C 4烷基磺酰基氧基、卤代C 1-C 4烷基磺酰基氧基、C 1-C 4烷氧基C 1-C 4烷氧基或卤 代C 1-C 4烷氧基C 1-C 4烷氧基；n选自0至5的整数，当n大于1时，R 11可相同或不同；
R 14、R 15、R 16或R 17可相同或不同，分别选自氢、卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基或C 3-C 4环烷基；
W选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基、C 1-C 4烷硫基或C 1-C 4烷基磺酰基；
所述含嘧啶的取代吡唑类化合物的盐为通式I-A或I-B所示的化合物与盐酸、硫酸、磷酸、甲酸、乙酸、三氟乙酸、草酸、甲磺酸、对甲苯磺酸、苯甲酸、邻苯二甲酸、马来酸、富马酸、山梨酸、苹果酸或柠檬酸形成的盐；
活性组分B选自呼吸抑制剂类杀菌剂、核酸代谢抑制剂类杀菌剂、细胞壁合成抑制剂类杀菌剂、信号传导作用抑制剂类杀菌剂、细胞骨架和运动蛋白抑制剂类杀菌剂、固醇生物合成抑制剂类杀菌剂、磷脂合成抑制剂类杀菌剂、甲硫氨酸生物合成抑制剂类杀菌剂、多位点抑制剂类杀菌剂、作用机制未知类杀菌剂中的一种或几种。
当活性组分A为通式I-A中的化合物或其盐时，优选，所述组合物为按重量比为1:50-50:1的活性组分A和活性组分B；
其中，活性组分A选自通式I-A中的化合物或其盐中的一种或几种；
式中：R 3选自氢、羟基、甲酰基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷硫基、C 2-C 4烯基硫基、C 2-C 4烯基、C 2-C 4炔基、卤代C 2-C 4烯基或卤代C 2-C 4炔基；R 4、R 5可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 6、R 7可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 8、R 9可相同或不同，分别选自氢、氰基、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基羰基或卤代C 1-C 4烷氧基羰基；R 11选自卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷基氨基、卤代C 1-C 4烷基氨基、二(C 1-C 4烷基)氨基、卤代二(C 1-C 4烷基)氨基或C 1-C 4烷硫基；n选自0至5的整数，当n为0时，苯环上无取代基；当n大于1时，R 11可相同或不同；R 14、R 15、R 16或R 17可相同或不同，分别选自氢、卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基或C 1-C 4烷氧基；W选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基或C 1-C 4烷硫基；
所述通式I-A所示化合物的盐为通式化合物与盐酸、硫酸、磷酸、甲酸、乙酸、三氟乙酸、草酸、甲磺酸、对甲苯磺酸、苯甲酸、邻苯 二甲酸或马来酸形成的盐；
活性组分B选自苯并烯氟菌唑(benzovindiflupyr)B1、氟唑菌苯胺(penflufen)B2、吡唑萘菌胺(isopyrazam)B3、氟唑菌酰胺(fluxapyroxad)B4、氟吡菌酰胺(fluopyram)B5、氟苯醚酰胺(flubeneteram)B6、氟唑环菌胺(sedaxane)B7、吡噻菌胺(penthiopyrad)B8、啶酰菌胺(boscalid)B9、联苯吡菌胺(bixafen)B10、氟酰胺(flutolanil)B11、呋吡菌胺(furametpyr)B12、噻呋酰胺(thifluzamide)B13、氟唑菌酰羟胺(pydiflumetofen)B14、氟茚唑菌胺(fluindapyr)B15、氟醚菌酰胺(fluopimomide)B16、异丙噻菌胺(isofetamid)B17、inpyrfluxam B18、isoflucypram B19、pyraziflumid B20、pyrapropoyne B21、萎锈灵(carboxin)B22、氧化萎锈灵(oxycarboxin)B23、甲呋酰胺(fenfuram)B24、灭锈胺(mepronil)B25、麦锈灵(benodanil)B26、氟吡菌胺(fluopicolide)B27、咪唑菌酮(fenamidone)B28、噁唑菌酮(famoxadone)B29、氰霜唑(cyazofamid)B30、唑嘧菌胺(ametoctradin)B31、氟啶胺(fluazinam)B32、fenpicoxamid B33、florylpicoxamid B34、吲唑磺菌胺(amisulbrom)B35、硅噻菌胺(silthiopham)B36、吡菌苯威(pyribencarb)B37、三苯基氯化锡(triphenyltin chloride)B38、二硝巴豆酸酯(cincxap)B39、敌螨普(dinocap)B40、氟吗啉(flumorph)B41、烯酰吗啉(dimethomorph)B42、双炔酰菌胺(mandipropamid)B43、苯酰菌胺(zoxamide)B44、甲霜灵(metalaxyl)B45、精甲霜灵(metalaxyl-M)B46、异丙菌胺(iprovalicarb)B47、霜脲氰(cymoxanil)B48、精苯霜灵(benalaxyl-M)B49、磺菌胺(flusulfamide)B50、噻酰菌胺(tiadinil)B51、噻唑菌胺(ethaboxam)B52、环氟菌胺(cyflufenamid)B53、环酰菌胺(fenhexamid)B54、双氯氰菌胺(diclocymet)B55、乙嘧酚磺酸酯(bupirimate)B56、二甲嘧酚(dimethirimol)B57、乙嘧酚(ethirimol)B58、噁霉灵(hymexazol)B59、辛噻酮(octhilinone)B60、呋酰胺(ofurace)B61、喹菌酮(chinomethionat)B62、噁霜灵(metidaxyl)B63、呋霜灵(furalaxyl)B64、咯菌腈(fludioxonil)B65、拌种咯(fenpicloni)B66、异菌脲(iprodione)B67、腐霉利(procymidone)B68、甲菌利(meclozolin)B69、乙菌利(chlozolinate)B70、菌核净(dimethachlon)B71、乙烯菌核利(vinclozolin)B72、乙霉威(diethofencarb)B73、苯菌酮(metrafenone)B74、pyriofenone B75、多菌灵(carbendazim)B76、甲基硫菌灵(thiophanate-methyl)B77、氰烯菌酯(phenamacril)B78、苯菌灵(benomyl)B79、麦穗宁(fuberidazole)B80、噻菌灵(thiabendazole)B81、硫菌灵(thiophanate)B82、戊菌隆(pencycuron)B83、乙环唑(etaconazole)B84、啶斑肟(ethanone)B85、氯苯嘧 啶醇(fenarimol)B86、腈苯唑(fenbuconazole)B87、苯锈啶(fenpropidine)B88、丁苯吗啉(fenpropimorph)B89、胺苯吡菌酮(fenpyrazamine)B90、氯氟醚菌唑(mefentrifluconazole)B91、氟苯嘧啶醇(nuarimol)B92、恶咪唑(oxpoconazole)B93、稻瘟酯(pefurazoate)B94、咪鲜胺(prochloraz)B95、螺环菌胺(spiroxamine)B96、啶菌噁唑(pyrisoxazole)B97、十三吗啉(tridemorph)B98、嗪氨灵(triforine)B99、十二环吗啉(dodemorph)B100、糠菌唑(bromuconazole)B101、抑芽唑(triapenthenol)B102、萘替芬(naftifine)B103、硅氟唑(simeconazole)B104、氟菌唑(triflumizole)B105、ipfentrifluconazole B106、四氯硝基苯(tecnazene)B107、地茂散(chloroneb)B108、氯硝胺(dicloran)B109、联苯(biphenyl)B110、敌瘟磷(edifenphos)B111、土菌灵(etridiazole)B112、碘代丙炔基丁基甲胺酸酯(iodocarb)B113、异稻瘟净(iprobenfos)B114、稻瘟灵(isoprothiolane)B115、氟噻唑吡乙酮(oxathiapiprolin)B116、fluoxapiproline B117、霜霉威(propamocarb)B118、硫菌威(prothiocarb)B119、吡菌磷(pyrazophos)B120、五氯硝基苯(quintozene)B121、甲基立枯磷(tolclofos-methyl)B122、苯噻菌胺(benthiavalicarb-isopropyl)B123、多抗霉素(polyoxin)B124、缬菌胺(valifenalate)B125、丁吡吗啉(pyrimorph)B126、灭瘟素(blasticidin-s)B127、嘧菌环胺(cyprodinil)B128、春雷霉素(kasugamycin)B129、嘧菌胺(mepanipyrim)B130、嘧霉胺(pyrimethanil)B131、链霉素(streptomycin)B132、土霉素(oxytetracycline)B133、代森锌(zineb)B134、代森锰锌(mancozeb)B135、代森联(metiram)B136、丙森锌(propineb)B137、代森锰(maneb)B138、代森铵(amobam)B139、代森钠(nabam)B140、代森硫(etem)B141、代森环(milneb)B142、代森锰铜(mancopper)B143、呋菌清(cufraneb)B144、硫黄(sulphur)B145、敌菌灵(anilazine)B146、克菌丹(captan)B147、灭螨猛(chinomethionat)B148、百菌清(chlorothalonil)B149、苯氟磺胺(dichlofluanid)B150、甲苯氟磺胺(tolylfluanid)B151、二氰蒽醌(dithianon)B152、氟酰亚胺(fluoroimide)B153、磺菌威(methasulfocarb)B154、敌菌丹(captafol)B155、灭菌丹(folpet)B156、双胍辛胺(iminoctadine)B157、双胍盐(guazatine)B158、噻唑锌(zinc thiazole)B159、喹啉铜(oxine-copper)B160、噻菌铜(thiodiazole-copper)B161、壬菌铜(cuppric nonyl phenolsulfonate)B162、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165、多果定(dodine)B166、pyridachlometyl B167、哒菌酮(diclomezine)B168、井冈霉素(validamycin)B169、嘧菌腙(ferimzone)B170、tebufloquin B171、咪唑嗪(triazoxide)B172、 quinofumelin B173、ipflufenoquin B174、dipymetitrone B175、teclofthalam B176中的一种或几种。
进一步优选，所述组合物为按重量比为1:20-20:1的活性组分A和活性组分B；
其中，活性组分A为通式I-A所示化合物或其盐中的一种或几种；
式中，R 3选自氢、羟基、甲酰基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷硫基、C 2-C 4烯基硫基、C 2-C 4烯基、C 2-C 4炔基、卤代C 2-C 4烯基或卤代C 2-C 4炔基；R 4、R 5可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 6、R 7可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 8、R 9可相同或不同，分别选自氢、氰基、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基羰基或卤代C 1-C 4烷氧基羰基；R 11选自卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷基氨基或卤代C 1-C 4烷基氨基；n选自0至5的整数，当n为0时，苯环上无取代基；当n大于1时，R 11可相同或不同；R 14、R 15、R 16或R 17可相同或不同，分别选自氢、卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；W选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基或C 1-C 4烷硫基；
所述通式I-A所示化合物的盐为通式化合物与盐酸、硫酸、磷酸、甲酸、乙酸、三氟乙酸、草酸或甲磺酸形成的盐；
活性组分B选自苯并烯氟菌唑(benzovindiflupyr)B1、氟唑菌苯胺(penflufen)B2、吡唑萘菌胺(isopyrazam)B3、氟唑菌酰胺(fluxapyroxad)B4、氟吡菌酰胺(fluopyram)B5、氟苯醚酰胺(flubeneteram)B6、氟唑环菌胺(sedaxane)B7、吡噻菌胺(penthiopyrad)B8、啶酰菌胺(boscalid)B9、联苯吡菌胺(bixafen)B10、氟酰胺(flutolanil)B11、呋吡菌胺(furametpyr)B12、噻呋酰胺(thifluzamide)B13、氟唑菌酰羟胺(pydiflumetofen)B14、氟茚唑菌胺(fluindapyr)B15、氟醚菌酰胺(fluopimomide)B16、异丙噻菌胺(isofetamid)B17、inpyrfluxam B18、isoflucypram B19、pyraziflumid B20、pyrapropoyne B21、麦锈灵(benodanil)B26、氟吡菌胺(fluopicolide)B27、咪唑菌酮(fenamidone)B28、噁唑菌酮(famoxadone)B29、氰霜唑(cyazofamid)B30、唑嘧菌胺(ametoctradin)B31、氟啶胺(fluazinam)B32、fenpicoxamid B33、florylpicoxamid B34、吲唑磺菌胺(amisulbrom)B35、硅噻菌胺(silthiopham)B36、吡菌苯威(pyribencarb)B37、氟吗啉(flumorph)B41、烯酰吗啉 (dimethomorph)B42、双炔酰菌胺(mandipropamid)B43、苯酰菌胺(zoxamide)B44、精甲霜灵(metalaxyl-M)B46、异丙菌胺(iprovalicarb)B47、霜脲氰(cymoxanil)B48、精苯霜灵(benalaxyl-M)B49、噻酰菌胺(tiadinil)B51、噻唑菌胺(ethaboxam)B52、乙嘧酚磺酸酯(bupirimate)B56、二甲嘧酚(dimethirimol)B57、乙嘧酚(ethirimol)B58、噁霉灵(hymexazol)B59、辛噻酮(octhilinone)B60、呋酰胺(ofurace)B61、喹菌酮(chinomethionat)B62、咯菌腈(fludioxonil)B65、拌种咯(fenpicloni)B66、异菌脲(iprodione)B67、腐霉利(procymidone)B68、菌核净(dimethachlon)B71、乙烯菌核利(vinclozolin)B72、乙霉威(diethofencarb)B73、苯菌酮(metrafenone)B74、pyriofenone B75、多菌灵(carbendazim)B76、甲基硫菌灵(thiophanate-methyl)B77、氰烯菌酯(phenamacril)B78、苯菌灵(benomyl)B79、啶斑肟(ethanone)B85、氯苯嘧啶醇(fenarimol)B86、腈苯唑(fenbuconazole)B87、苯锈啶(fenpropidine)B88、胺苯吡菌酮(fenpyrazamine)B90、氯氟醚菌唑(mefentrifluconazole)B91、氟苯嘧啶醇(nuarimol)B92、恶咪唑(oxpoconazole)B93、稻瘟酯(pefurazoate)B94、咪鲜胺(prochloraz)B95、螺环菌胺(spiroxamine)B96、啶菌噁唑(pyrisoxazole)B97、硅氟唑(simeconazole)B104、ipfentrifluconazole B106、敌瘟磷(edifenphos)B111、异稻瘟净(iprobenfos)B114、稻瘟灵(isoprothiolane)B115、氟噻唑吡乙酮(oxathiapiprolin)B116、fluoxapiproline B117、霜霉威(propamocarb)B118、硫菌威(prothiocarb)B119、吡菌磷(pyrazophos)B120、五氯硝基苯(quintozene)B121、甲基立枯磷(tolclofos-methyl)B122、苯噻菌胺(benthiavalicarb-isopropyl)B123、多抗霉素(polyoxin)B124、缬菌胺(valifenalate)B125、丁吡吗啉(pyrimorph)B126、嘧菌环胺(cyprodinil)B128、春雷霉素(kasugamycin)B129、嘧菌胺(mepanipyrim)B130、嘧霉胺(pyrimethanil)B131、链霉素(streptomycin)B132、代森锌(zineb)B134、代森锰锌(mancozeb)B135、代森联(metiram)B136、丙森锌(propineb)B137、代森锰(maneb)B138、代森铵(amobam)B139、代森环(milneb)B142、代森锰铜(mancopper)B143、硫黄(sulphur)B145、敌菌灵(anilazine)B146、克菌丹(captan)B147、百菌清(chlorothalonil)B149、苯氟磺胺(dichlofluanid)B150、甲苯氟磺胺(tolylfluanid)B151、磺菌威(methasulfocarb)B154、敌菌丹(captafol)B155、灭菌丹(folpet)B156、噻唑锌(zinc thiazole)B159、喹啉铜(oxine-copper)B160、噻菌铜(thiodiazole-copper)B161、壬菌铜(cuppric nonyl phenolsulfonate)B162、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165、pyridachlometyl B167、井冈霉素(validamycin) B169、嘧菌腙(ferimzone)B170、tebufloquin B171、quinofumelin B173、ipflufenoquin B174、dipymetitrone B175、teclofthalam B176中的一种或几种。
再进一步优选，所述组合物为按重量比为1:10-10:1的活性组分A和活性组分B；
其中，活性组分A选自通式I-A中的化合物或其盐中的一种或几种；
式中，R 3选自氢、羟基、甲酰基或C 1-C 4烷基；R 4、R 5可相同或不同，分别选自氢、卤素或C 1-C 4烷基；R 6、R 7可相同或不同，分别选自氢、卤素或C 1-C 4烷基；R 8、R 9可相同或不同，分别选自氢、氰基、卤素或C 1-C 4烷基；R 11选自卤素、羟基、氨基、氰基、硝基或C 1-C 4烷基；n选自0至5的整数，当n为0时，苯环上无取代基；当n大于1时，R 11可相同或不同；R 14、R 15、R 16或R 17可相同或不同，分别选自氢、卤素、羟基、氨基、氰基、硝基或C 1-C 4烷基；W选自氢、卤素或C 1-C 4烷基；
所述通式I-A所示化合物的盐为通式化合物与盐酸、硫酸、磷酸、甲酸或乙酸形成的盐；
活性组分B选自苯并烯氟菌唑(benzovindiflupyr)B1、氟唑菌苯胺(penflufen)B2、吡唑萘菌胺(isopyrazam)B3、氟唑菌酰胺(fluxapyroxad)B4、氟吡菌酰胺(fluopyram)B5、氟苯醚酰胺(flubeneteram)B6、氟唑环菌胺(sedaxane)B7、吡噻菌胺(penthiopyrad)B8、啶酰菌胺(boscalid)B9、联苯吡菌胺(bixafen)B10、噻呋酰胺(thifluzamide)B13、氟唑菌酰羟胺(pydiflumetofen)B14、氟茚唑菌胺(fluindapyr)B15、氟醚菌酰胺(fluopimomide)B16、inpyrfluxam B18、isoflucypram B19、pyraziflumid B20、pyrapropoyne B21、麦锈灵(benodanil)B26、氟吡菌胺(fluopicolide)B27、咪唑菌酮(fenamidone)B28、噁唑菌酮(famoxadone)B29、氰霜唑(cyazofamid)B30、唑嘧菌胺(ametoctradin)B31、氟啶胺(fluazinam)B32、fenpicoxamid B33、florylpicoxamid B34、硅噻菌胺(silthiopham)B36、氟吗啉(flumorph)B41、烯酰吗啉(dimethomorph)B42、双炔酰菌胺(mandipropamid)B43、苯酰菌胺(zoxamide)B44、精甲霜灵(metalaxyl-M)B46、异丙菌胺(iprovalicarb)B47、霜脲氰(cymoxanil)B48、噻酰菌胺(tiadinil)B51、噻唑菌胺(ethaboxam)B52、乙嘧酚磺酸酯(bupirimate)B56、乙嘧酚(ethirimol)B58、噁霉灵(hymexazol)B59、辛噻酮(octhilinone)B60、喹菌酮(chinomethionat)B62、咯菌腈(fludioxonil)B65、异菌脲(iprodione)B67、腐霉利(procymidone)B68、乙霉威(diethofencarb)B73、苯菌酮(metrafenone)B74、pyriofenone B75、多菌灵(carbendazim) B76、甲基硫菌灵(thiophanate-methyl)B77、氰烯菌酯(phenamacril)B78、腈苯唑(fenbuconazole)B87、、氯氟醚菌唑(mefentrifluconazole)B91、氟苯嘧啶醇(nuarimol)B92、咪鲜胺(prochloraz)B95、螺环菌胺(spiroxamine)B96、啶菌噁唑(pyrisoxazole)B97、硅氟唑(simeconazole)B104、ipfentrifluconazole B106、异稻瘟净(iprobenfos)B114、稻瘟灵(isoprothiolane)B115、氟噻唑吡乙酮(oxathiapiprolin)B116、fluoxapiproline B117、霜霉威(propamocarb)B118、五氯硝基苯(quintozene)B121、甲基立枯磷(tolclofos-methyl)B122、苯噻菌胺(benthiavalicarb-isopropyl)B123、多抗霉素(polyoxin)B124、缬菌胺(valifenalate)B125、丁吡吗啉(pyrimorph)B126、嘧菌环胺(cyprodinil)B128、春雷霉素(kasugamycin)B129、嘧霉胺(pyrimethanil)B131、链霉素(streptomycin)B132、代森锌(zineb)B134、代森锰锌(mancozeb)B135、代森联(metiram)B136、丙森锌(propineb)B137、硫黄(sulphur)B145、克菌丹(captan)B147、百菌清(chlorothalonil)B149、苯氟磺胺(dichlofluanid)B150、敌菌丹(captafol)B155、灭菌丹(folpet)B156、噻唑锌(zinc thiazole)B159、喹啉铜(oxine-copper)B160、噻菌铜(thiodiazole-copper)B161、壬菌铜(cuppric nonyl phenolsulfonate)B162、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165、pyridachlometyl B167、井冈霉素(validamycin)B169、tebufloquin B171、quinofumelin B173、ipflufenoquin B174、dipymetitrone B175、teclofthalam B176中的一种或几种。
当活性组分A为通式I-B中的化合物或其盐时，优选，所述组合物为按重量比为1:50-50:1的活性组分A和活性组分B；
其中，活性组分A选自通式I-B中的化合物或其盐中的一种或几种；
式中，R 1选自氢、卤素、氰基、硝基、氨基、羧基、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 1-C 4烷硫基、卤代C 1-C 4烷硫基、C 1-C 4烷基亚磺酰基、C 1-C 4烷基磺酰基、C 2-C 4烯基、卤代C 2-C 4烯基、C 2-C 4炔基或卤代C 2-C 4炔基；R 2选自氢、卤素、氰基、硝基、氨基、羧基、甲酰基、C 1-C 4烷基或卤代C 1-C 4烷基；R 3选自氢、羟基、甲酰基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷硫基、C 2-C 4烯基硫基、C 2-C 4烯基、C 2-C 4炔基、卤代C 2-C 4烯基或卤代C 2-C 4炔基；R 4、R 5可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 6、R 7可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 8、R 9可相同或不同，分别选自氢、氰基、卤素、 C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基羰基或卤代C 1-C 4烷氧基羰基；R 11选自卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷基氨基、卤代C 1-C 4烷基氨基、二(C 1-C 4烷基)氨基、卤代二(C 1-C 4烷基)氨基或C 1-C 4烷硫基；n选自0至5的整数，当n为0时，苯环上无取代基；当n大于1时，R 11可相同或不同；W选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基或C 1-C 4烷硫基；
所述通式I-B所示化合物的盐为通式化合物与盐酸、硫酸、磷酸、甲酸、乙酸、三氟乙酸、草酸、甲磺酸、对甲苯磺酸、苯甲酸、邻苯二甲酸或马来酸形成的盐；
活性组分B选自苯并烯氟菌唑(benzovindiflupyr)B1、氟唑菌苯胺(penflufen)B2、吡唑萘菌胺(isopyrazam)B3、氟唑菌酰胺(fluxapyroxad)B4、氟吡菌酰胺(fluopyram)B5、氟苯醚酰胺(flubeneteram)B6、氟唑环菌胺(sedaxane)B7、吡噻菌胺(penthiopyrad)B8、啶酰菌胺(boscalid)B9、联苯吡菌胺(bixafen)B10、氟酰胺(flutolanil)B11、呋吡菌胺(furametpyr)B12、噻呋酰胺(thifluzamide)B13、氟唑菌酰羟胺(pydiflumetofen)B14、氟茚唑菌胺(fluindapyr)B15、氟醚菌酰胺(fluopimomide)B16、异丙噻菌胺(isofetamid)B17、inpyrfluxam B18、isoflucypram B19、pyraziflumid B20、pyrapropoyne B21、萎锈灵(carboxin)B22、氧化萎锈灵(oxycarboxin)B23、甲呋酰胺(fenfuram)B24、灭锈胺(mepronil)B25、麦锈灵(benodanil)B26、氟吡菌胺(fluopicolide)B27、咪唑菌酮(fenamidone)B28、噁唑菌酮(famoxadone)B29、氰霜唑(cyazofamid)B30、唑嘧菌胺(ametoctradin)B31、氟啶胺(fluazinam)B32、fenpicoxamid B33、florylpicoxamid B34、吲唑磺菌胺(amisulbrom)B35、硅噻菌胺(silthiopham)B36、吡菌苯威(pyribencarb)B37、三苯基氯化锡(triphenyltin chloride)B38、二硝巴豆酸酯(cincxap)B39、敌螨普(dinocap)B40、氟吗啉(flumorph)B41、烯酰吗啉(dimethomorph)B42、双炔酰菌胺(mandipropamid)B43、苯酰菌胺(zoxamide)B44、甲霜灵(metalaxyl)B45、精甲霜灵(metalaxyl-M)B46、异丙菌胺(iprovalicarb)B47、霜脲氰(cymoxanil)B48、精苯霜灵(benalaxyl-M)B49、磺菌胺(flusulfamide)B50、噻酰菌胺(tiadinil)B51、噻唑菌胺(ethaboxam)B52、环氟菌胺(cyflufenamid)B53、环酰菌胺(fenhexamid)B54、双氯氰菌胺(diclocymet)B55、乙嘧酚磺酸酯(bupirimate)B56、二甲嘧酚(dimethirimol)B57、乙嘧酚(ethirimol)B58、噁霉灵(hymexazol)B59、辛噻酮(octhilinone)B60、呋酰胺(ofurace)B61、喹菌酮 (chinomethionat)B62、噁霜灵(metidaxyl)B63、呋霜灵(furalaxyl)B64、咯菌腈(fludioxonil)B65、拌种咯(fenpicloni)B66、异菌脲(iprodione)B67、腐霉利(procymidone)B68、甲菌利(meclozolin)B69、乙菌利(chlozolinate)B70、菌核净(dimethachlon)B71、乙烯菌核利(vinclozolin)B72、乙霉威(diethofencarb)B73、苯菌酮(metrafenone)B74、pyriofenone B75、多菌灵(carbendazim)B76、甲基硫菌灵(thiophanate-methyl)B77、氰烯菌酯(phenamacril)B78、苯菌灵(benomyl)B79、麦穗宁(fuberidazole)B80、噻菌灵(thiabendazole)B81、硫菌灵(thiophanate)B82、戊菌隆(pencycuron)B83、乙环唑(etaconazole)B84、啶斑肟(ethanone)B85、氯苯嘧啶醇(fenarimol)B86、腈苯唑(fenbuconazole)B87、苯锈啶(fenpropidine)B88、丁苯吗啉(fenpropimorph)B89、胺苯吡菌酮(fenpyrazamine)B90、氯氟醚菌唑(mefentrifluconazole)B91、氟苯嘧啶醇(nuarimol)B92、恶咪唑(oxpoconazole)B93、稻瘟酯(pefurazoate)B94、咪鲜胺(prochloraz)B95、螺环菌胺(spiroxamine)B96、啶菌噁唑(pyrisoxazole)B97、十三吗啉(tridemorph)B98、嗪氨灵(triforine)B99、十二环吗啉(dodemorph)B100、糠菌唑(bromuconazole)B101、抑芽唑(triapenthenol)B102、萘替芬(naftifine)B103、硅氟唑(simeconazole)B104、氟菌唑(triflumizole)B105、ipfentrifluconazole B106、四氯硝基苯(tecnazene)B107、地茂散(chloroneb)B108、氯硝胺(dicloran)B109、联苯(biphenyl)B110、敌瘟磷(edifenphos)B111、土菌灵(etridiazole)B112、碘代丙炔基丁基甲胺酸酯(iodocarb)B113、异稻瘟净(iprobenfos)B114、稻瘟灵(isoprothiolane)B115、氟噻唑吡乙酮(oxathiapiprolin)B116、fluoxapiproline B117、霜霉威(propamocarb)B118、硫菌威(prothiocarb)B119、吡菌磷(pyrazophos)B120、五氯硝基苯(quintozene)B121、甲基立枯磷(tolclofos-methyl)B122、苯噻菌胺(benthiavalicarb-isopropyl)B123、多抗霉素(polyoxin)B124、缬菌胺(valifenalate)B125、丁吡吗啉(pyrimorph)B126、灭瘟素(blasticidin-s)B127、嘧菌环胺(cyprodinil)B128、春雷霉素(kasugamycin)B129、嘧菌胺(mepanipyrim)B130、嘧霉胺(pyrimethanil)B131、链霉素(streptomycin)B132、土霉素(oxytetracycline)B133、代森锌(zineb)B134、代森锰锌(mancozeb)B135、代森联(metiram)B136、丙森锌(propineb)B137、代森锰(maneb)B138、代森铵(amobam)B139、代森钠(nabam)B140、代森硫(etem)B141、代森环(milneb)B142、代森锰铜(mancopper)B143、呋菌清(cufraneb)B144、硫黄(sulphur)B145、敌菌灵(anilazine)B146、克菌丹(captan)B147、灭螨猛(chinomethionat)B148、百 菌清(chlorothalonil)B149、苯氟磺胺(dichlofluanid)B150、甲苯氟磺胺(tolylfluanid)B151、二氰蒽醌(dithianon)B152、氟酰亚胺(fluoroimide)B153、磺菌威(methasulfocarb)B154、敌菌丹(captafol)B155、灭菌丹(folpet)B156、双胍辛胺(iminoctadine)B157、双胍盐(guazatine)B158、噻唑锌(zinc thiazole)B159、喹啉铜(oxine-copper)B160、噻菌铜(thiodiazole-copper)B161、壬菌铜(cuppric nonyl phenolsulfonate)B162、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165、多果定(dodine)B166、pyridachlometyl B167、哒菌酮(diclomezine)B168、井冈霉素(validamycin)B169、嘧菌腙(ferimzone)B170、tebufloquin B171、咪唑嗪(triazoxide)B172、quinofumelin B173、ipflufenoquin B174、dipymetitrone B175、teclofthalam B176中的一种或几种。
进一步优选，所述组合物为按重量比为1:20-20:1的活性组分A和活性组分B；
其中，活性组分A选自通式I-B中的化合物或其盐中的一种或几种；
式中，R 1选自氢、卤素、氰基、硝基、氨基、羧基、C 1-C 4烷基或卤代C 1-C 4烷基；R 2选自氢、卤素、氰基、硝基、氨基、羧基、甲酰基、C 1-C 4烷基或卤代C 1-C 4烷基；R 3选自氢、羟基、甲酰基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷硫基、C 2-C 4烯基硫基、C 2-C 4烯基、C 2-C 4炔基、卤代C 2-C 4烯基或卤代C 2-C 4炔基；R 4、R 5可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 6、R 7可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 8、R 9可相同或不同，分别选自氢、氰基、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基羰基或卤代C 1-C 4烷氧基羰基；R 11选自卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷基氨基或卤代C 1-C 4烷基氨基；n选自0至5的整数，当n为0时，苯环上无取代基；当n大于1时，R 11可相同或不同；W选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基或C 1-C 4烷硫基；
所述通式I-B所示化合物的盐为通式化合物与盐酸、硫酸、磷酸、甲酸、乙酸、三氟乙酸、草酸或甲磺酸形成的盐；
活性组分B选自苯并烯氟菌唑(benzovindiflupyr)B1、氟唑菌苯胺(penflufen)B2、吡唑萘菌胺(isopyrazam)B3、氟唑菌酰胺(fluxapyroxad)B4、氟吡菌酰胺(fluopyram)B5、氟苯醚酰胺(flubeneteram)B6、氟唑环菌胺(sedaxane)B7、吡噻菌胺 (penthiopyrad)B8、啶酰菌胺(boscalid)B9、联苯吡菌胺(bixafen)B10、氟酰胺(flutolanil)B11、呋吡菌胺(furametpyr)B12、噻呋酰胺(thifluzamide)B13、氟唑菌酰羟胺(pydiflumetofen)B14、氟茚唑菌胺(fluindapyr)B15、氟醚菌酰胺(fluopimomide)B16、异丙噻菌胺(isofetamid)B17、inpyrfluxam B18、isoflucypram B19、pyraziflumid B20、pyrapropoyne B21、麦锈灵(benodanil)B26、氟吡菌胺(fluopicolide)B27、咪唑菌酮(fenamidone)B28、噁唑菌酮(famoxadone)B29、氰霜唑(cyazofamid)B30、唑嘧菌胺(ametoctradin)B31、氟啶胺(fluazinam)B32、fenpicoxamid B33、florylpicoxamid B34、吲唑磺菌胺(amisulbrom)B35、硅噻菌胺(silthiopham)B36、吡菌苯威(pyribencarb)B37、氟吗啉(flumorph)B41、烯酰吗啉(dimethomorph)B42、双炔酰菌胺(mandipropamid)B43、苯酰菌胺(zoxamide)B44、精甲霜灵(metalaxyl-M)B46、异丙菌胺(iprovalicarb)B47、霜脲氰(cymoxanil)B48、精苯霜灵(benalaxyl-M)B49、噻酰菌胺(tiadinil)B51、噻唑菌胺(ethaboxam)B52、乙嘧酚磺酸酯(bupirimate)B56、二甲嘧酚(dimethirimol)B57、乙嘧酚(ethirimol)B58、噁霉灵(hymexazol)B59、辛噻酮(octhilinone)B60、呋酰胺(ofurace)B61、喹菌酮(chinomethionat)B62、咯菌腈(fludioxonil)B65、拌种咯(fenpicloni)B66、异菌脲(iprodione)B67、腐霉利(procymidone)B68、菌核净(dimethachlon)B71、乙烯菌核利(vinclozolin)B72、乙霉威(diethofencarb)B73、苯菌酮(metrafenone)B74、pyriofenone B75、多菌灵(carbendazim)B76、甲基硫菌灵(thiophanate-methyl)B77、氰烯菌酯(phenamacril)B78、苯菌灵(benomyl)B79、啶斑肟(ethanone)B85、氯苯嘧啶醇(fenarimol)B86、腈苯唑(fenbuconazole)B87、苯锈啶(fenpropidine)B88、胺苯吡菌酮(fenpyrazamine)B90、氯氟醚菌唑(mefentrifluconazole)B91、氟苯嘧啶醇(nuarimol)B92、恶咪唑(oxpoconazole)B93、稻瘟酯(pefurazoate)B94、咪鲜胺(prochloraz)B95、螺环菌胺(spiroxamine)B96、啶菌噁唑(pyrisoxazole)B97、硅氟唑(simeconazole)B104、ipfentrifluconazole B106、敌瘟磷(edifenphos)B111、异稻瘟净(iprobenfos)B114、稻瘟灵(isoprothiolane)B115、氟噻唑吡乙酮(oxathiapiprolin)B116、fluoxapiproline B117、霜霉威(propamocarb)B118、硫菌威(prothiocarb)B119、吡菌磷(pyrazophos)B120、五氯硝基苯(quintozene)B121、甲基立枯磷(tolclofos-methyl)B122、苯噻菌胺(benthiavalicarb-isopropyl)B123、多抗霉素(polyoxin)B124、缬菌胺(valifenalate)B125、丁吡吗啉(pyrimorph)B126、嘧菌环胺(cyprodinil)B128、春雷霉素(kasugamycin)B129、嘧菌胺(mepanipyrim)B130、嘧霉胺(pyrimethanil)B131、链霉素 (streptomycin)B132、代森锌(zineb)B134、代森锰锌(mancozeb)B135、代森联(metiram)B136、丙森锌(propineb)B137、代森锰(maneb)B138、代森铵(amobam)B139、代森环(milneb)B142、代森锰铜(mancopper)B143、硫黄(sulphur)B145、敌菌灵(anilazine)B146、克菌丹(captan)B147、百菌清(chlorothalonil)B149、苯氟磺胺(dichlofluanid)B150、甲苯氟磺胺(tolylfluanid)B151、磺菌威(methasulfocarb)B154、敌菌丹(captafol)B155、灭菌丹(folpet)B156、噻唑锌(zinc thiazole)B159、喹啉铜(oxine-copper)B160、噻菌铜(thiodiazole-copper)B161、壬菌铜(cuppric nonyl phenolsulfonate)B162、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165、pyridachlometyl B167、井冈霉素(validamycin)B169、嘧菌腙(ferimzone)B170、tebufloquin B171、quinofumelin B173、ipflufenoquin B174、dipymetitrone B175、teclofthalam B176中的一种或几种。
再进一步优选，所述组合物为按重量比为1:10-10:1的活性组分A和活性组分B；
其中，活性组分A选自通式I-B中的化合物或其盐中的一种或几种；
式中，R 1选自氢、卤素、氰基、硝基、氨基、羧基或C 1-C 4烷基；R 2选自氢、卤素、氰基、硝基、氨基、羧基、甲酰基或C 1-C 4烷基；R 3选自氢、羟基、甲酰基或C 1-C 4烷基；R 4、R 5可相同或不同，分别选自氢、卤素或C 1-C 4烷基；R 6、R 7可相同或不同，分别选自氢、卤素或C 1-C 4烷基；R 8、R 9可相同或不同，分别选自氢、氰基、卤素或C 1-C 4烷基；R 11选自卤素、羟基、氨基、氰基、硝基或C 1-C 4烷基；n选自0至5的整数，当n为0时，苯环上无取代基；当n大于1时，R 11可相同或不同；W选自氢、卤素或C 1-C 4烷基；
所述通式I-B所示化合物的盐为通式化合物与盐酸、硫酸、磷酸、甲酸或乙酸形成的盐；
活性组分B选自苯并烯氟菌唑(benzovindiflupyr)B1、氟唑菌苯胺(penflufen)B2、吡唑萘菌胺(isopyrazam)B3、氟唑菌酰胺(fluxapyroxad)B4、氟吡菌酰胺(fluopyram)B5、氟苯醚酰胺(flubeneteram)B6、氟唑环菌胺(sedaxane)B7、吡噻菌胺(penthiopyrad)B8、啶酰菌胺(boscalid)B9、联苯吡菌胺(bixafen)B10、噻呋酰胺(thifluzamide)B13、氟唑菌酰羟胺(pydiflumetofen)B14、氟茚唑菌胺(fluindapyr)B15、氟醚菌酰胺(fluopimomide)B16、inpyrfluxam B18、isoflucypram B19、pyraziflumid B20、pyrapropoyne B21、麦锈灵(benodanil)B26、氟吡菌胺(fluopicolide)B27、咪唑菌酮(fenamidone)B28、噁唑菌酮(famoxadone)B29、 氰霜唑(cyazofamid)B30、唑嘧菌胺(ametoctradin)B31、氟啶胺(fluazinam)B32、fenpicoxamid B33、florylpicoxamid B34、硅噻菌胺(silthiopham)B36、氟吗啉(flumorph)B41、烯酰吗啉(dimethomorph)B42、双炔酰菌胺(mandipropamid)B43、苯酰菌胺(zoxamide)B44、精甲霜灵(metalaxyl-M)B46、异丙菌胺(iprovalicarb)B47、霜脲氰(cymoxanil)B48、噻酰菌胺(tiadinil)B51、噻唑菌胺(ethaboxam)B52、乙嘧酚磺酸酯(bupirimate)B56、乙嘧酚(ethirimol)B58、噁霉灵(hymexazol)B59、辛噻酮(octhilinone)B60、喹菌酮(chinomethionat)B62、咯菌腈(fludioxonil)B65、异菌脲(iprodione)B67、腐霉利(procymidone)B68、乙霉威(diethofencarb)B73、苯菌酮(metrafenone)B74、pyriofenone B75、多菌灵(carbendazim)B76、甲基硫菌灵(thiophanate-methyl)B77、氰烯菌酯(phenamacril)B78、腈苯唑(fenbuconazole)B87、、氯氟醚菌唑(mefentrifluconazole)B91、氟苯嘧啶醇(nuarimol)B92、咪鲜胺(prochloraz)B95、螺环菌胺(spiroxamine)B96、啶菌噁唑(pyrisoxazole)B97、硅氟唑(simeconazole)B104、ipfentrifluconazole B106、异稻瘟净(iprobenfos)B114、稻瘟灵(isoprothiolane)B115、氟噻唑吡乙酮(oxathiapiprolin)B116、fluoxapiproline B117、霜霉威(propamocarb)B118、五氯硝基苯(quintozene)B121、甲基立枯磷(tolclofos-methyl)B122、苯噻菌胺(benthiavalicarb-isopropyl)B123、多抗霉素(polyoxin)B124、缬菌胺(valifenalate)B125、丁吡吗啉(pyrimorph)B126、嘧菌环胺(cyprodinil)B128、春雷霉素(kasugamycin)B129、嘧霉胺(pyrimethanil)B131、链霉素(streptomycin)B132、代森锌(zineb)B134、代森锰锌(mancozeb)B135、代森联(metiram)B136、丙森锌(propineb)B137、硫黄(sulphur)B145、克菌丹(captan)B147、百菌清(chlorothalonil)B149、苯氟磺胺(dichlofluanid)B150、、敌菌丹(captafol)B155、灭菌丹(folpet)B156、噻唑锌(zinc thiazole)B159、喹啉铜(oxine-copper)B160、噻菌铜(thiodiazole-copper)B161、壬菌铜(cuppric nonyl phenolsulfonate)B162、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165、pyridachlometyl B167、井冈霉素(validamycin)B169、tebufloquin B171、quinofumelin B173、ipflufenoquin B174、dipymetitrone B175、teclofthalam B176中的一种或几种。
一种杀菌组合物的应用，所述杀菌组合物用于制备防治植物病原性真菌、细菌病害的药物
所述植物病原性真菌、细菌病害为植物白粉病、锈病、黑星病、叶霉病、纹枯病、立枯病、黑痣病、黑穗病、黑粉病、霜霉病、晚疫病、疫病、霜疫霉病、黑胫病、绵腐病、猝倒病、绵疫病、白锈病、 黑斑病、叶斑病、早疫病、炭疽病、褐斑病、蔓枯病、灰霉病、菌核病、腐烂病、根腐病、赤霉病、软腐病、白叶枯病、叶枯病、角斑病、圆斑病、白叶枯病、青枯病、溃疡病或黄龙病。
一种杀菌制剂，制剂有效成分为所述的杀菌组合物，杀菌组合物的重量百分含量为0.1-95％。
根据农作物病害的发生程度，在农作物种植区域内，本发明组合物的使用浓度为5-500mg/L(有效成分含量，下同)，优选50-200mg/L。
本发明组合物中活性组分A和至少一种活性组分B按照本发明提供的合适配比，预先配制好或在使用现场配制或将两组分单独依次使用。
本发明组合物适合用于树木(苹果、橡胶、梨、柑橘、山楂、板栗、花椒、枸杞、芒果、木瓜、荔枝、香蕉、桃树等)、藤蔓植物(葡萄等)、瓜菜类(番茄、茄子、辣椒、黄瓜、甜瓜、冬瓜、西瓜、南瓜、苦瓜、丝瓜、佛手瓜、葫芦、西葫芦、莴苣、马铃薯、胡萝卜)、豆类(豌豆、菜豆、豇豆)、禾谷类(小麦、水稻、玉米、高粱等)、油料作物(油菜、大豆、花生、芝麻等)、葱蒜类(葱、蒜、洋葱)、经济作物(烟草等)、花卉植物和草坪的真菌、细菌病害防治，以及种子处理、水果保鲜等应用。
本发明杀菌组合物特别适合防治下列植物病害：苹果树白粉病、橡胶树白粉病、柑橘白粉病、山楂白粉病、板栗白粉病、花椒白粉病、枸杞白粉病、芒果白粉病、木瓜白粉病、棒子白粉病、葡萄白粉病、番茄白粉病、茄子白粉病、辣椒白粉病、黄瓜白粉病、甜瓜白粉病、冬瓜白粉病、西瓜白粉病、南瓜白粉病、苦瓜白粉病、丝瓜白粉病、佛手瓜白粉病、葫芦白粉病、西葫芦白粉病、莴苣白粉病、豌豆白粉病、菜豆白粉病、小麦白粉病、大麦白粉病、月季白粉病、玫瑰白粉病、菊花白粉病、草坪草白粉病、胡萝卜白粉病、苹果树锈病、梨树锈病、大豆锈病、豌豆锈病、菜豆锈病、豇豆锈病、小麦锈病、大麦锈病、玉米锈病、葱锈病、蒜锈病、洋葱锈病、草坪草锈病、苹果树炭疽病、橡胶树炭疽病、梨树炭疽病、柑橘炭疽病、山楂炭疽病、板栗炭疽病、花椒炭疽病、枸杞炭疽病、芒果炭疽病、木瓜炭疽病、榛子炭疽病、葡萄炭疽病、番茄炭疽病、茄子炭疽病、辣椒炭疽病、甜瓜炭疽病、冬瓜炭疽病、西瓜炭疽病、南瓜炭疽病、苦瓜炭疽病、丝瓜炭疽病、佛手瓜炭疽病、葫芦炭疽病、西葫芦炭疽病、莴苣炭疽病、黄瓜霜霉病、葡萄霜霉病、甜瓜霜霉病、苦瓜霜霉病、丝瓜霜霉病、番茄晚疫病、马铃薯晚疫病、辣椒疫病、黄瓜猝倒病、茄子猝倒病、辣椒猝倒病、梨树褐斑病、黄瓜褐斑病、梨树黑斑病、月季黑斑病、玫瑰黑斑病、菊花黑斑病、大豆褐斑病、豇豆红斑病、苹果斑点落叶病、菜豆轮斑病、茄子棒孢叶斑病、马铃薯黑痣病、小麦纹枯病、水 稻纹枯病、水稻恶苗病、大豆立枯病、豌豆立枯病、菜豆立枯病、葱立枯病、蒜立枯病、洋葱立枯病、草坪草立枯病、柑橘溃疡病、柑橘黄龙病、水稻白叶枯病、水稻细菌性条斑病、番茄青枯病、黄瓜细菌性角斑病及由灰葡萄孢属和核盘菌属病原菌引起的作物灰霉病、菌核病等。
本发明所具有优点：
本发明按不同比例将活性组分A和杀菌剂活性组分B组合，“观察效力”大于“计算效力”，协同增效作用十分明显，能降低药剂的用量，减少环境污染。本发明选用不同作用机理的杀菌剂混合，有助于延缓病原菌产生抗药性，为农业生产和农药工业所面临的杀菌剂抗性问题提供一种有效的解决手段，延长药剂的使用寿命。
具体实施方式
本发明组合物对有害真菌、细菌病害的协同增效作用可通过下列实施例作进一步说明，但本发明绝非仅限于此。其中所述的活性组分即为本发明的杀菌组合物中的化合物A与杀菌剂B；
化合物A的制备参见WO2016184378中的记载，杀菌剂B选自呼吸抑制剂类杀菌剂、核酸代谢抑制剂类杀菌剂、细胞壁合成抑制剂类杀菌剂、信号传导作用抑制剂类杀菌剂、细胞骨架和运动蛋白抑制剂类杀菌剂、固醇生物合成抑制剂类杀菌剂、磷脂合成抑制剂类杀菌剂、细胞壁合成抑制剂类杀菌剂、甲硫氨酸生物合成抑制剂类杀菌剂、多位点抑制剂类杀菌剂、作用机制未知类杀菌剂中的一种或几种。
测试方法及评价方法如下：
待测活性样品分别为活性组分A、活性组分B、活性组分A与活性组分B的组合物。
所述活性组分A为活性组分A1、活性组分A2、活性组分A3和活性组分A4中的一种或几种；
其中，活性组分A1为通式I-A所示的化合物A1；
活性组分A2为由化合物A1与硫酸形成的盐；
化合物A1为
Figure PCTCN2020130513-appb-000003
式中，R 3选自氢，R 4、R 5分别选自氢，R 6、R 7分别选自氢，R 8、R 9分别选自氢，R 11选自4-氯，n＝1,R 14、R 15、R 16或R 17分别选自氢，W选自氢，即为化合物A1；
活性组分A3为通式I-B所示的化合物A3；
活性组分A4为由化合物A3与硫酸形成的盐：
化合物A3为
Figure PCTCN2020130513-appb-000004
式中：
R 3选自氢，R 4、R 5分别选自氢R 6、R 7分别选自氢，R 8、R 9分别选自氢，R 11选自4-氯，n＝1，R 14、R 15、R 16或R 17分别选自氢，W选自氢，即为化合物A3。
活性组分B为苯并烯氟菌唑B1、氟唑菌酰胺B4、氟吡菌酰胺B5、啶酰菌胺B9、噻呋酰胺B13、氟唑菌酰羟胺B14、氟吡菌胺B27、唑嘧菌胺B31、氟啶胺B32、fenpicoxamid B33、氟吗啉B41、烯酰吗啉B42、双炔酰菌胺B43、苯酰菌胺B44、精甲霜灵B46、乙嘧酚磺酸酯B56、乙嘧酚B58、咯菌腈B65、乙霉威B73、苯菌酮B74、氰烯菌酯B78、氯氟醚菌唑B91、咪鲜胺B95、氟噻唑吡乙酮B116、fluoxapiproline B117、多抗霉素B124、春雷霉素B129、代森锌B134、代森锰锌B135、代森联B136、丙森锌B137、克菌丹B147、百菌清B149、噻唑锌B159、喹啉铜B160、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165。
待测组合物为活性组分A1、各活性组分B、活性组分A1分别和各活性组分B；其中，活性组分B为苯并烯氟菌唑B1、氟唑菌酰胺B4、氟吡菌酰胺B5、啶酰菌胺B9、噻呋酰胺B13、氟唑菌酰羟胺B14、氟吡菌胺B27、唑嘧菌胺B31、氟啶胺B32、fenpicoxamid B33、氟吗啉B41、烯酰吗啉B42、双炔酰菌胺B43、苯酰菌胺B44、精甲霜灵B46、乙嘧酚磺酸酯B56、乙嘧酚B58、咯菌腈B65、乙霉威B73、苯菌酮B74、氰烯菌酯B78、氯氟醚菌唑B91、咪鲜胺B95、氟噻唑吡乙酮B116、fluoxapiproline B117、多抗霉素B124、春雷霉素B129、代森锌B134、代森锰锌B135、代森联B136、丙森锌B137、克菌丹B147、百菌清B149、噻唑锌B159、喹啉铜B160、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165组成的组合物。
待测组合物为活性组分A2分别与/或与苯并烯氟菌唑B1、氟唑菌酰胺B4、氟吡菌酰胺B5、啶酰菌胺B9、噻呋酰胺B13、氟唑菌酰羟胺B14、氟吡菌胺B27、唑嘧菌胺B31、氟啶胺B32、fenpicoxamid B33、氟吗啉B41、烯酰吗啉B42、双炔酰菌胺B43、苯酰菌胺B44、 精甲霜灵B46、乙嘧酚磺酸酯B56、乙嘧酚B58、咯菌腈B65、乙霉威B73、苯菌酮B74、氰烯菌酯B78、氯氟醚菌唑B91、咪鲜胺B95、氟噻唑吡乙酮B116、fluoxapiproline B117、多抗霉素B124、春雷霉素B129、代森锌B134、代森锰锌B135、代森联B136、丙森锌B137、克菌丹B147、百菌清B149、噻唑锌B159、喹啉铜B160、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165组成的组合物。
待测组合物为活性组分A3分别与/或与苯并烯氟菌唑B1、氟唑菌酰胺B4、氟吡菌酰胺B5、啶酰菌胺B9、噻呋酰胺B13、氟唑菌酰羟胺B14、氟吡菌胺B27、唑嘧菌胺B31、氟啶胺B32、fenpicoxamid B33、氟吗啉B41、烯酰吗啉B42、双炔酰菌胺B43、苯酰菌胺B44、精甲霜灵B46、乙嘧酚磺酸酯B56、乙嘧酚B58、咯菌腈B65、乙霉威B73、苯菌酮B74、氰烯菌酯B78、氯氟醚菌唑B91、咪鲜胺B95、氟噻唑吡乙酮B116、fluoxapiproline B117、多抗霉素B124、春雷霉素B129、代森锌B134、代森锰锌B135、代森联B136、丙森锌B137、克菌丹B147、百菌清B149、噻唑锌B159、喹啉铜B160、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165组成的组合物。
待测组合物为活性组分A4分别与/或与苯并烯氟菌唑B1、氟唑菌酰胺B4、氟吡菌酰胺B5、啶酰菌胺B9、噻呋酰胺B13、氟唑菌酰羟胺B14、氟吡菌胺B27、唑嘧菌胺B31、氟啶胺B32、fenpicoxamid B33、氟吗啉B41、烯酰吗啉B42、双炔酰菌胺B43、苯酰菌胺B44、精甲霜灵B46、乙嘧酚磺酸酯B56、乙嘧酚B58、咯菌腈B65、乙霉威B73、苯菌酮B74、氰烯菌酯B78、氯氟醚菌唑B91、咪鲜胺B95、氟噻唑吡乙酮B116、fluoxapiproline B117、多抗霉素B124、春雷霉素B129、代森锌B134、代森锰锌B135、代森联B136、丙森锌B137、克菌丹B147、百菌清B149、噻唑锌B159、喹啉铜B160、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165组成的组合物。
具体方式：
将上述各活性组分或组合物用丙酮溶解(丙酮量与喷液量的体积比等于或小于0.05)，用含有0.1％吐温80的水稀释，配制成所需浓度待测液，另按设定比例配制组合物的待测液。在作物喷雾机上，将待测液喷施于温室培养的整齐一致寄主植物(施药前未接种，未用其它药物)上，24小时后进行病害接种。依据病害特点，将需要控温保湿培养的病害植物接种后放在气候室中培养，待病害完成侵染后，移入温室培养；将不需要保湿培养的病害植物接种后直接移入温室培养。待对照充分发病后进行病情调查，记录调查的总叶数、病叶数和病级数。
病害分级方法：
0级：全株无病；
1级：病斑面积点整个叶面积的5％以下；
3级：病斑面积点整个叶面积的6-10％；
5级：病斑面积点整个叶面积的11-20％；
7级：病斑面积点整个叶面积的21-50％；
9级：病斑面积点整个叶面积的51％以上。
活性组分或组合物的观察效力(C obs)使用农药药效评价常用公式(校正防效计算公式)计算：
Figure PCTCN2020130513-appb-000005
Figure PCTCN2020130513-appb-000006
效力为“0”表示处理作物的侵染水平与未处理对照作物的侵染水平相同；效力为“100”表示处理作物未受侵染。
组合物的预期效力(C exp)使用Abbott方法(见刘学敏等，杀菌剂混用的增效作用，农药科学与管理，2002，23(5)，12-15)确定。
C exp＝X+Y–XY/100
式中：
X：使用浓度为a时的活性组分A的效力；
Y：使用浓度为b时的活性组分B的效力。
组合物的协同作用用观察效力(C obs)和预期效力(C exp)的比值评价。当比值(增效比)>1，组合物表现增效作用；当比值(增效比)＝1，组合物表现加合作用；当比值(增效比)<1，表示组合物为拮抗作用。
实施例1 防治黄瓜白粉病试验1
将品种为“津研-4”的盆栽两叶期黄瓜幼苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将黄白粉病菌孢子用接器喷雾于叶片上，并在温室内培养，10天后待对照充分发病后进行病情调查。
各单独活性组分及本发明组合物防治黄瓜白粉病的活性数据及协同作用见表1和表2。
下述表2结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对黄瓜白粉病表现为增效作用。
表1单独活性组分的活性
Figure PCTCN2020130513-appb-000007
Figure PCTCN2020130513-appb-000008
表2本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000009
Figure PCTCN2020130513-appb-000010
Figure PCTCN2020130513-appb-000011
实施例2 防治黄瓜白粉病试验2
将品种为“新泰密刺”的盆栽两叶期黄瓜幼苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将黄白粉病菌孢子用接器喷雾于叶片上，并在温室内培养，10天后待对照充分发病后进行病情调查。
各单独活性组分及本发明组合物防治黄瓜白粉病的活性数据及协同作用见表3和表4。
下述表4结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对黄瓜白粉病表现为增效作用。
表3单独活性组分的活性
Figure PCTCN2020130513-appb-000012
Figure PCTCN2020130513-appb-000013
表4本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000014
实施例3 防治甜瓜白粉病试验
将品种为“蜜仙甜瓜”的盆栽四叶期甜瓜苗(试验前已剪除1-2叶，只保留3-4叶)用各活性组分或组合物的水溶液(浓度如下表所述)喷雾处理，24小时后，将甜瓜白粉病菌孢子悬浮液接种在叶片上，并在温室内培养，15天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治甜瓜白粉病的活性数据见表5。
本发明组合物防治甜瓜白粉病的活性数据及协同作用见表6。
下述表6结果显示，组合物的观察效力(C obs)和预期效力(C exp) 的比值均>1，说明组合物在试验配比范围内对甜瓜白粉病表现为增效作用。
表5单独活性组分的活性
Figure PCTCN2020130513-appb-000015
表6本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000016
Figure PCTCN2020130513-appb-000017
实施例4 防治辣椒白粉病试验
将品种为“青圆椒”的盆栽六叶期辣椒苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将辣椒白粉病菌孢子接种在叶片背面，并在气候室中培养，待病害完成侵染后，移入温室培养，20-25天后待对照充分发病后进行病情调查。
本发明各单独活性组分防治辣椒白粉病的活性数据见表7和表8。
本发明组合物防治辣椒白粉病的活性数据及协同作用见表9和表10。
下述表9、表10结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对辣椒白粉病表现为增效作用。
表7单独活性组分的活性
Figure PCTCN2020130513-appb-000018
表8单独活性组分的活性
Figure PCTCN2020130513-appb-000019
Figure PCTCN2020130513-appb-000020
表9本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000021
表10本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000022
实施例5 防治菜豆白粉病试验
将品种为“丰收1号”的盆栽两叶期菜豆幼苗用各活性组份或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，喷雾后自然晾干，24小时后，将菜豆白粉病病原菌孢子水悬浮液(5×10 6个/ml)接种在菜豆叶片上，自然晾干后，移入温室培养，培养条件(温度：昼23-28℃，夜18-20℃)，待对照充分发病后进行病情调查。
本发明各单独活性组分防治菜豆白粉病的活性数据见表11。
本发明组合物防治菜豆白粉病的活性数据及协同作用见表12。
下述表12结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对菜豆白粉病表现为增效作用。
表11单独活性组分的活性
Figure PCTCN2020130513-appb-000023
表12本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000024
实施例6 防治烟草白粉病试验
将品种为“CN89”的盆栽六叶期烟苗用各活性组分或组合物的水溶液(浓度如下表所述)喷雾处理，24小时后，将烟草白粉病菌孢子悬浮液接种在烟苗叶片上，直接移入温室培养，20天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治烟草白粉病的活性数据见表13。
本发明组合物防治烟草白粉病的活性数据及协同作用见表14。
下述表14结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对烟草白粉病表现为增效作用。
表13单独活性组分的活性
Figure PCTCN2020130513-appb-000025
表14本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000026
Figure PCTCN2020130513-appb-000027
实施例7 防治玉米锈病试验
将品种为“金黄糯”的盆栽两叶期玉米幼苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将玉米锈病菌孢子悬浮液接种在玉米叶片上，并在气候室中培养，待病害完成侵染后，移入温室培养，7天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治玉米锈病的活性数据见表15。
本发明组合物防治玉米锈病的活性数据及协同作用见表16。
下述表16结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对玉米锈病表现为增效作用。
表15单独活性组分的活性
Figure PCTCN2020130513-appb-000028
Figure PCTCN2020130513-appb-000029
表16本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000030
Figure PCTCN2020130513-appb-000031
实施例8 防治黄瓜霜霉病试验1
将品种为“新泰密刺”的盆栽两叶期黄瓜幼苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将黄瓜霜霉病病原菌孢子囊悬浮液接种在黄瓜叶片上，并在气候室中培养，待病害完成侵染后，移入温室培养，7天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治黄瓜霜霉病的活性数据见表17。
本发明组合物防治黄瓜霜霉病的活性数据及协同作用见表18。
下述表18结果显示，组合物的观察效力(Cobs)和预期效力(Cexp)的比值均大于1，说明组合物在试验配比范围内对黄瓜霜霉病表现为增效作用。
表17单独活性组分的活性
Figure PCTCN2020130513-appb-000032
表18本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000033
Figure PCTCN2020130513-appb-000034
Figure PCTCN2020130513-appb-000035
Figure PCTCN2020130513-appb-000036
实施例9 防治黄瓜霜霉病试验2
将品种为“新泰密刺”的盆栽两叶期黄瓜幼苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将黄瓜霜霉病病原菌孢子囊悬浮液接种在黄瓜叶片上，并在气候室中培养，待病害完成侵染后，移入温室培养，7天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治黄瓜霜霉病的活性数据见表19。
本发明组合物防治黄瓜霜霉病的活性数据及协同作用见表20。
下述表20结果显示，组合物的观察效力(Cobs)和预期效力(Cexp)的比值均大于1，说明组合物在试验配比范围内对黄瓜霜霉病表现为增效作用。
表19单独活性组分的活性
Figure PCTCN2020130513-appb-000037
Figure PCTCN2020130513-appb-000038
表20本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000039
Figure PCTCN2020130513-appb-000040
Figure PCTCN2020130513-appb-000041
实施例10 防治黄瓜霜霉病试验3
试验参照国家标准GB/T 17980.26-2000：农药田间药效试验准则(一)-杀菌剂防治黄瓜霜霉病的相关内容执行。试验地设在沈阳市苏家屯区八一镇保护地，黄瓜品种为新泰密刺，管理水平中，试验时，黄瓜处于结瓜期，霜霉病轻度发生，小区面积约为25m 2；按试验设定剂量对黄瓜进行药剂喷雾处理；试验共施药2次，施药间隔7天，第二次药后10天，调查各小区黄瓜霜霉病发病情况。每小区分4点取样，每点取8株，每株自上而下调查全株叶片发病情况。
本发明各单独的活性组分防治黄瓜霜霉病的活性数据见表21。
本发明组合物防治黄瓜霜霉病的活性数据及协同作用见表22。
下述表22结果显示，组合物的观察效力(Cobs)和预期效力(Cexp)的比值均大于1，说明组合物在试验配比范围内对黄瓜霜霉病表现为增效作用。
表21单独活性组分的活性
Figure PCTCN2020130513-appb-000042
Figure PCTCN2020130513-appb-000043
表22本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000044
实施例11 防治黄瓜霜霉病试验4
将品种为“新泰密刺”的盆栽两叶期黄瓜幼苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将黄瓜霜霉病病原菌孢子囊悬浮液接种在黄瓜叶片上，并在气候室中培养，待病害完成侵染后，移入温室培养，7天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治黄瓜霜霉病的活性数据见表23。
本发明组合物防治黄瓜霜霉病的活性数据及协同作用见表24。
下述表24结果显示，组合物的观察效力(Cobs)和预期效力(Cexp)的比值均大于1，说明组合物在试验配比范围内对黄瓜霜霉病表现为增效作用。
表23单独活性组分的活性
Figure PCTCN2020130513-appb-000045
Figure PCTCN2020130513-appb-000046
表24本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000047
Figure PCTCN2020130513-appb-000048
实施例12 防治葡萄霜霉病试验1
将品种为“无核白鸡心”的盆栽五叶期葡萄苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将葡萄霜霉病病原菌孢子囊悬浮液接种在葡萄叶片上，并将葡萄苗放置于气候室中培养，待病害完成侵染后，移入温室培养，7天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治葡萄霜霉病的活性数据见表25。
本发明组合物防治葡萄霜霉病的活性数据及协同作用见表26。
下述表26结果显示，组合物的观察效力(Cobs)和预期效力(Cexp)的比值均大于1，说明组合物在试验配比范围内对葡萄霜霉病表现为增效作用。
表25单独活性组分的活性
Figure PCTCN2020130513-appb-000049
表26本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000050
Figure PCTCN2020130513-appb-000051
Figure PCTCN2020130513-appb-000052
实施例13 防治葡萄霜霉病试验2
将品种为“无核白鸡心”的盆栽五叶期葡萄苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将葡萄霜霉病病原菌孢子囊悬浮液接种在葡萄叶片上，并将葡萄苗放置于气候室中培养，待病害完成侵染后，移入温室培养，7天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治葡萄霜霉病的活性数据见表27。
本发明组合物防治葡萄霜霉病的活性数据及协同作用见表28。
下述表28结果显示，组合物的观察效力(Cobs)和预期效力(Cexp)的比值均大于1，说明组合物在试验配比范围内对葡萄霜霉病表现为增效作用。
表27单独活性组分的活性
Figure PCTCN2020130513-appb-000053
Figure PCTCN2020130513-appb-000054
表28本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000055
Figure PCTCN2020130513-appb-000056
实施例14 防治葡萄霜霉病试验3
将品种为“无核白鸡心”的盆栽五叶期葡萄苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将葡萄霜霉病病原菌孢子囊悬浮液接种在葡萄叶片上，并将葡萄苗放置于气候室中培养，待病害完成侵染后，移入温室培养，7天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治葡萄霜霉病的活性数据见表29。
本发明组合物防治葡萄霜霉病的活性数据及协同作用见表30。
下述表30结果显示，组合物的观察效力(Cobs)和预期效力(Cexp)的比值均大于1，说明组合物在试验配比范围内对葡萄霜霉病表现为增效作用。
表29单独活性组分的活性
Figure PCTCN2020130513-appb-000057
Figure PCTCN2020130513-appb-000058
表30本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000059
Figure PCTCN2020130513-appb-000060
实施例15 防治葡萄霜霉病试验4
将品种为“无核白鸡心”的盆栽五叶期葡萄苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将葡萄霜霉病病原菌孢子囊悬浮液接种在葡萄叶片上，并将葡萄苗放置于气候室中培养，待病害完成侵染后，移入温室培养，7天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治葡萄霜霉病的活性数据见表31。
本发明组合物防治葡萄霜霉病的活性数据及协同作用见表32。
下述表32结果显示，组合物的观察效力(Cobs)和预期效力(Cexp)的比值均大于1，说明组合物在试验配比范围内对葡萄霜霉病表现为增效作用。
表31单独活性组分的活性
Figure PCTCN2020130513-appb-000061
表32本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000062
Figure PCTCN2020130513-appb-000063
实施例16 防治白菜霜霉病试验
将品种为“四季小白菜”的盆栽五叶期白菜苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将白菜霜霉病菌孢子囊接种在叶片背面，并在气候室中培养，待病害 完成侵染后，移入温室培养，5-7天后待对照充分发病后进行病情调查。
本发明各单独活性组分防治白菜霜霉病的活性数据见表33。
本发明组合物防治白菜霜霉病的活性数据及协同作用见表34。
下述表34结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对白菜霜霉病表现为增效作用。
表33单独活性组分的活性
Figure PCTCN2020130513-appb-000064
表34本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000065
Figure PCTCN2020130513-appb-000066
实施例17 防治向日葵霜霉病试验
将品种为“三道眉”的盆栽六叶期向日葵苗(试验前已剪除1-4叶，只保留5-6叶)用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将向日葵霜霉病病菌孢子囊悬液接种在叶片上，并在气候室中培养，待病害完成侵染后，移入温室培养，12天后待对照充分发病后进行病情调查。
本发明各单独活性组分防治向日葵霜霉病的活性数据见表35。
本发明组合物防治向日葵霜霉病的活性数据及协同作用见表36。
下述表36结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对向日葵霜霉病表现为增效作用。
表35单独活性组分的活性
Figure PCTCN2020130513-appb-000067
Figure PCTCN2020130513-appb-000068
表36本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000069
实施例18 防治番茄晚疫病试验1
将品种为“粉太郞”的盆栽五叶期番茄苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将番茄晚疫病病原菌孢子囊悬浮液接种在番茄叶片上，并将番茄苗放置于气候室中培养，待病害完成侵染后，移入温室培养，7天后待对照充 分发病后进行病情调查。
本发明各单独活性组分防治番茄晚疫病的活性数据见表37。
本发明组合物防治番茄晚疫病的活性数据及协同作用见表38。
下述表38结果显示，组合物的观察效力(Cobs)和预期效力(Cexp)的比值均大于1，说明组合物在试验配比范围内对番茄晚疫病表现为增效作用。
表37单独活性组分的活性
Figure PCTCN2020130513-appb-000070
表38本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000071
Figure PCTCN2020130513-appb-000072
实施例19 防治番茄晚疫病试验2
将品种为“粉太郞”的盆栽五叶期番茄苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将番茄晚疫病病原菌孢子囊悬浮液接种在番茄叶片上，并将番茄苗放置于气候室中培养，待病害完成侵染后，移入温室培养，7天后待对照充分发病后进行病情调查。
本发明各单独活性组分防治番茄晚疫病的活性数据见表39。
本发明组合物防治番茄晚疫病的活性数据及协同作用见表40。
下述表40结果显示，组合物的观察效力(Cobs)和预期效力(Cexp)的比值均大于1，说明组合物在试验配比范围内对番茄晚疫病表现为增效作用。
表39单独活性组分的活性
Figure PCTCN2020130513-appb-000073
Figure PCTCN2020130513-appb-000074
表40本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000075
Figure PCTCN2020130513-appb-000076
实施例20 防治黄瓜炭疽病试验1
将品种为“新泰密刺”的盆栽两叶期黄瓜幼苗用各活性组分或组合物的水溶液喷雾处理，喷雾后自然晾干，24小时后，将黄瓜炭疽病病原菌孢子水悬浮液接种在黄瓜叶片上，并在气候室中培养，待病害完成侵染后，移入温室培养，7天后进行病情调查，根据叶片上病菌侵染的发展程度对叶片分级，记录调查的总叶数、病叶数和病级数，根据公式计算药剂效力。
本发明各单独活性组分防治黄瓜炭疽病的活性数据见表41。
本发明组合物防治黄瓜炭疽病的活性数据及协同作用见表42。
下述表42结果显示，组合物的观察效力(Cobs)和预期效力(Cexp)的比值均大于1，说明组合物在试验配比范围内对黄瓜炭疽病表现为增效作用。
表41单独活性组分的活性
Figure PCTCN2020130513-appb-000077
表42本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000078
实施例21 防治黄瓜炭疽病试验2
将品种为“新泰密刺”的盆栽两叶期黄瓜幼苗用各活性组分或组合物的水溶液喷雾处理，喷雾后自然晾干，24小时后，将黄瓜炭疽病病原菌孢子水悬浮液接种在黄瓜叶片上，并在气候室中培养，待病害完成侵染后，移入温室培养，7天后进行病情调查，根据叶片上病菌侵染的发展程度对叶片分级，记录调查的总叶数、病叶数和病级数，根据公式计算药剂效力。
本发明各单独活性组分防治黄瓜炭疽病的活性数据见表43。
本发明组合物防治黄瓜炭疽病的活性数据及协同作用见表44。
下述表44结果显示，组合物的观察效力(Cobs)和预期效力(Cexp)的比值均大于1，说明组合物在试验配比范围内对黄瓜炭疽病表现为增效作用。
表43单独活性组分的活性
Figure PCTCN2020130513-appb-000079
Figure PCTCN2020130513-appb-000080
表44本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000081
实施例22 防治辣椒炭疽病试验
将品种为“青圆椒”的盆栽六叶期辣椒苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，24小时后，将辣椒炭疽病菌孢子悬浮液接种在叶片背面，并在气候室中培养，待病害完成侵染后，移入温室培养，5-7天后待对照充分发病后进行病情调查。
本发明各单独活性组分防治辣椒炭疽病的活性数据见表45。
本发明组合物防治辣椒炭疽病的活性数据及协同作用见表46。
下述表46结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对辣椒炭疽病表现为增效作用。
表45单独活性组分的活性
Figure PCTCN2020130513-appb-000082
Figure PCTCN2020130513-appb-000083
表46本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000084
Figure PCTCN2020130513-appb-000085
实施例23 防治茄子褐斑病试验
将品种为“辽茄1号”的盆栽五叶期茄子苗用各活性组分或组合物的水溶液(浓度如下表所述)喷雾处理，24小时后，将茄子褐斑病菌孢子悬浮液接种在茄子叶片上，并在气候室中培养，待病害完成侵染后，移入温室培养，10天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治茄子褐斑病的活性数据见表47。
本发明组合物防治茄子褐斑病的活性数据及协同作用见表48。
下述表48结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对茄子褐斑病表现为增效作用。
表47单独活性组分的活性
Figure PCTCN2020130513-appb-000086
表48本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000087
实施例24 防治茄子棒孢叶斑病试验
将品种为“辽茄1号”的盆栽五叶期茄子苗用各活性组分或组合物的水溶液(浓度如下表所述)喷雾处理，24小时后，将茄子棒孢叶斑病菌孢子悬浮液接种在茄子叶片上，并在气候室中培养，待病害完成侵染后，移入温室培养，8天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治茄子棒孢叶斑病的活性数据见表49。
本发明组合物防治茄子棒孢叶斑病的活性数据及协同作用见表50。
下述表50结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对茄子棒孢叶斑病表现为增效作用。
表49单独活性组分的活性
Figure PCTCN2020130513-appb-000088
Figure PCTCN2020130513-appb-000089
表50本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000090
Figure PCTCN2020130513-appb-000091
实施例25 防治梨黑斑病试验
取品种为“香梨”的盆栽苗嫩叶，表面消毒后用无菌水冲洗干净并阴干，备用。用各活性组分或组合物的水溶液(浓度如下表所述)浸渍处理，24小时后，将梨黑斑病菌孢子悬浮液接种在叶片上，置于培养皿内(含2％水琼脂)恒温光照培养，14天后，待对照充分发病后进行病情调查。
本发明各单独的活性组分防治梨黑斑病的活性数据见表51。
本发明组合物防治梨黑斑病的活性数据及协同作用见表52。
下述表52结果显示，组合物的观察效力(C obs)和预期效力(C exp) 的比值均>1，说明组合物在试验配比范围内对梨黑斑病表现为增效作用。
表51单独活性组分的活性
Figure PCTCN2020130513-appb-000092
表52本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000093
Figure PCTCN2020130513-appb-000094
实施例26 防治花生叶斑病试验1
将品种为“白沙”的盆栽两对复叶平展期花生苗用各活性组分或组合物的水溶液(浓度如下表所述)喷雾处理，24小时后，将花生褐病菌孢子悬浮液接种在叶片上，并在气候室中培养，待病害完成侵染后，移入温室培养，10-12天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治花生叶斑病的活性数据见表53。
本发明组合物防治花生叶斑病的活性数据及协同作用见表54。
下述表54结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对花生叶斑病表现为增效作用。
表53单独活性组分的活性
Figure PCTCN2020130513-appb-000095
表54本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000096
实施例27 防治花生叶斑病试验2
将品种为“白沙”的盆栽两对复叶平展期花生苗用各活性组分或组合物的水溶液(浓度如下表所述)喷雾处理，24小时后，将花生褐病菌孢子悬浮液接种在叶片上，并在气候室中培养，待病害完成侵染后，移入温室培养，10-12天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治花生叶斑病的活性数据见表55。
本发明组合物防治花生叶斑病的活性数据及协同作用见表56。
下述表56结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对花生叶斑病表现为增效作用。
表55单独活性组分的活性
Figure PCTCN2020130513-appb-000097
Figure PCTCN2020130513-appb-000098
表56本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000099
实施例28 防治小麦赤霉病试验
将品种为“辽春18”的盆栽二叶期小麦苗用各活性组分或组合物的水溶液(浓度如下表所述)喷雾处理，24小时后，将小麦赤霉病菌孢子悬浮液接种在叶片上，并在温室内培养，5天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治小麦赤霉病的活性数据见表57。
本发明组合物防治小麦赤霉病的活性数据及协同作用见表58。
下述表58结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对小麦赤霉病表现为增效作用。
表57单独活性组分的活性
Figure PCTCN2020130513-appb-000100
Figure PCTCN2020130513-appb-000101
表58本发明组合物的活性及协同作用及协同作用
Figure PCTCN2020130513-appb-000102
实施例29 防治水稻纹枯病试验1
将品种为“龙稻18”的盆栽二叶期水稻苗用各活性组分或组合物的水溶液(浓度如下表所述)喷雾处理，24小时后，将水稻纹枯病菌菌丝悬浮液接种在水稻叶片上，并在温室内培养，5天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治水稻纹枯病的活性数据见表59。
本发明组合物防治水稻纹枯病的活性数据及协同作用见表60。
下述表60结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对水稻纹枯病表现为增效作用。
表59单独活性组分的活性
Figure PCTCN2020130513-appb-000103
表60本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000104
Figure PCTCN2020130513-appb-000105
实施例30 防治水稻纹枯病试验2
将品种为“龙稻18”的盆栽二叶期水稻苗用各活性组分或组合物的水溶液(浓度如下表所述)喷雾处理，24小时后，将水稻纹枯病菌菌丝悬浮液接种在水稻叶片上，并在温室内培养，5天后待对照充分发病后进行病情调查。
本发明各单独的活性组分防治水稻纹枯病的活性数据见表61。
本发明组合物防治水稻纹枯病的活性数据及协同作用见表62。
下述表62结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对水稻纹枯病表现为增效作用。
表61单独活性组分的活性
Figure PCTCN2020130513-appb-000106
表62本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000107
Figure PCTCN2020130513-appb-000108
实施例31 防治水稻白叶枯病试验
将水稻(品种为越光)种植于温室的相同盆钵中，8株/钵，待生长至四叶期时，用各活性组分或组合物的水溶液喷雾处理，24小时后，将活化好的水稻白叶枯病菌株均匀喷洒于水稻叶片，并在人工气保湿24小时，然后移入温室继续培养。待清水对照充分发病后，测量各处理的叶片病斑长度，通过下列公式计算病害抑制率即观察效力。
Figure PCTCN2020130513-appb-000109
本发明各单独的活性组分防治水稻白叶枯病的活性数据见表63。
本发明组合物防治水稻白叶枯病的活性数据及协同作用见表64。
下述表64结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对水稻白叶枯病表现为增效作用。
表63单独活性组分的活性
Figure PCTCN2020130513-appb-000110
表64本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000111
实施例32 对辣椒炭疽病治疗试验
将品种为“青圆椒”的盆栽六叶期辣椒苗接种辣椒炭疽病菌孢子悬浮液，并在气候室中培养，24小时后，用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，然后移入温室培养，5-7天后待对照充分发病后进行病情调查。
本发明各单独的活性组分和组合物对辣椒炭疽病的治疗活性数据见表65、表66。
下述表65、表66结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对辣椒炭疽病表现为增效作用。
表65活性组分的治疗效果及组合物的协同作用
Figure PCTCN2020130513-appb-000112
Figure PCTCN2020130513-appb-000113
表66活性组分的治疗效果及组合物的协同作用
Figure PCTCN2020130513-appb-000114
实施例33 防治辣椒白粉病持效性试验
将品种为“青圆椒”的盆栽六叶期辣椒苗用各活性组分或组合物的水溶液(有效成分浓度如下表所述)喷雾处理，于1天、3天、5天、7天、10天后，将辣椒白粉病菌孢子用接种器喷雾于叶片背面， 并在温室内培养，20-25天待对照充分发病后进行病情调查。
各单独活性组分及本发明组合物防治辣椒白粉病的活性数据见表67。
下述表67结果显示，药后随着接种时间延长，本发明单独组分和组合物对辣椒白粉病的观察效力也逐渐降低；相同浓度下，药后5天接种，单独组分的观察效力均低50％，组合物的观察效力均高于60％；药后10天接种，单独组分的观察效力不明显，组合物的观察效力均在30％左右，显示出明显的防治效果。说明本发明的单独组分以组合物形式使用，增强了药剂对辣椒白粉病的持效活性。
表67活性组分的持效活性及协同作用
Figure PCTCN2020130513-appb-000115
实施例34 防治黄瓜白粉病田间试验
在日光温室内，于黄瓜(品种为“水果黄瓜”)白粉病发病中期，用各活性组分或组合物的水溶液(浓度如下表所述)喷雾处理，并于15天后，进行病情调查。
本发明各单独的活性组分防治黄瓜白粉病的活性数据见表68。
本发明组合物防治黄瓜白粉病的活性数据及协同作用见表69。
下述表69结果显示，组合物的观察效力(C obs)和预期效力(C exp)的比值均>1，说明组合物在试验配比范围内对田间的黄瓜白粉病表现为增效作用。
表68单独活性组分的活性
Figure PCTCN2020130513-appb-000116
Figure PCTCN2020130513-appb-000117
表69本发明组合物的活性及协同作用
Figure PCTCN2020130513-appb-000118

Claims (10)

  1. 一种杀菌组合物，其特征在于：组合物为A、B两种活性组分，活性组分A和活性组分B之间的重量比为1:99-99:1；
    其中，活性组分A为含嘧啶的取代吡唑类化合物或其盐中的一种或几种；活性组分B选自一种杀菌剂。
  2. 根据权利要求1所述的杀菌组合物，其特征在于：所述含嘧啶的取代吡唑类化合物为通式I-A或I-B所示的化合物或其盐：
    Figure PCTCN2020130513-appb-100001
    式中：
    R 1选自氢、卤素、氰基、硝基、氨基、羧基、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 1-C 4烷硫基、卤代C 1-C 4烷硫基、C 1-C 4烷基亚磺酰基、C 1-C 4烷基磺酰基、C 2-C 4烯基、卤代C 2-C 4烯基、C 2-C 4炔基、卤代C 2-C 4炔基、C 3-C 4烯氧基、卤代C 3-C 4烯氧基、C 3-C 4炔氧基、卤代C 3-C 4炔氧基、C 1-C 4烷基氨基、二(C 1-C 4烷基)氨基、C 1-C 4烷基氨基羰基、卤代C 1-C 4烷基氨基羰基、C 1-C 4烷氧基羰基、卤代C 1-C 4烷氧基羰基、C 1-C 4烷氧基C 1-C 4烷基或C 1-C 4烷硫基C 1-C 4烷基；
    R 2选自氢、卤素、氰基、硝基、氨基、羧基、甲酰基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；
    R 3选自氢、羟基、甲酰基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷硫基、C 2-C 4烯基硫基、C 2-C 4烯基、C 2-C 4炔基、卤代C 2-C 4烯基、卤代C 2-C 4炔基、C 1-C 4烷氧基C 1-C 4烷基、卤代C 1-C 4烷氧基C 1-C 4烷基、C 1-C 4烷硫基C 1-C 4烷基、卤代C 1-C 4烷硫基C 1-C 4烷基、C 1-C 4烷基亚磺酰基、卤代C 1-C 4烷基亚磺酰基、C 1-C 4烷基磺酰基、卤代C 1-C 4烷基磺酰基、C 1-C 4烷基氨基磺酰基、二(C 1-C 4烷基)氨基磺酰基、C 1-C 4烷基磺 酰基氨基羰基、C 1-C 4烷基羰基氨基磺酰基、C 3-C 4环烷基氧基羰基、C 1-C 4烷基羰基、卤代C 1-C 4烷基羰基、C 1-C 4烷氧基羰基、卤代C 1-C 4烷氧基羰基、C 1-C 4烷基羰基C 1-C 4烷基、C 1-C 4烷氧基羰基C 1-C 4烷基、C 1-C 4烷基氨基羰基、二(C 1-C 4烷基)氨基羰基、C 2-C 4烯氧基羰基、C 2-C 4炔氧基羰基、C 1-C 4烷氧基C 1-C 4烷氧基羰基、C 1-C 4烷基氨基硫基、二(C 1-C 4烷基)氨基硫基、芳基羰基C 1-C 4烷基、芳基羰基、芳氧基羰基、芳基C 1-C 4烷基氧基羰基、芳基C 1-C 4烷基、杂芳基羰基C 1-C 4烷基、杂芳基羰基、杂芳氧基羰基、杂芳基C 1-C 4烷基氧基羰基或杂芳基C 1-C 4烷基；
    R 4、R 5可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；其中，R 4、R 5与其相连的C还可组成C 3-C 4的环；
    R 6、R 7可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；其中，R 6、R 7与其相连的C还可组成C 3-C 4的环；
    R 8、R 9可相同或不同，分别选自氢、氰基、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基羰基、卤代C 1-C 4烷氧基羰基、未取代的或被1-5个R 11取代的芳基、芳甲基、芳基羰基、芳甲基羰基、芳氧基羰基、杂芳基、杂芳甲基、杂芳基羰基、杂芳甲基羰基或杂芳氧基羰基；
    R 11选自卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷基氨基、卤代C 1-C 4烷基氨基、二(C 1-C 4烷基)氨基、卤代二(C 1-C 4烷基)氨基、C 1-C 4烷硫基、卤代C 1-C 4烷硫基、C 2-C 4烯基、C 2-C 4炔基、C 2-C 4烯氧基、卤代C 2-C 4烯氧基、C 2-C 4炔氧基、卤代C 2-C 4炔氧基、C 1-C 4烷基磺酰基、卤代C 1-C 4烷基磺酰基、C 1-C 4烷基羰基、卤代C 1-C 4烷基羰基、C 1-C 4烷氧基羰基、卤代C 1-C 4烷氧基羰基、C 1-C 4烷氧基C 1-C 4烷基、卤代C 1-C 4烷氧基C 1-C 4烷基、C 1-C 4烷硫基C 1-C 4烷基、卤代C 1-C 4烷硫基C 1-C 4烷基、C 1-C 4烷氧基羰基C 1-C 4烷基、卤代C 1-C 4烷氧基羰基C 1-C 4烷基、C 1-C 4烷硫基羰基C 1-C 4烷基、卤代C 1-C 4烷硫基羰基C 1-C 4烷基、C 1-C 4烷基羰基氧基、卤代C 1-C 4烷基羰基氧基、C 1-C 4烷氧基羰基氧基、卤代C 1-C 4烷氧基羰基氧基、C 1-C 4烷基磺酰基氧基、卤代C 1-C 4烷基磺酰基氧基、C 1-C 4烷氧基C 1-C 4烷氧基或卤代C 1-C 4烷氧基C 1-C 4烷氧基；n选自0至5的整数，当n大于1时，R 11可相同或不同；
    R 14、R 15、R 16或R 17可相同或不同，分别选自氢、卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基或C 3-C 4环烷基；
    W选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基、C 1-C 4烷硫基或C 1-C 4烷基磺酰基；
    所述含嘧啶的取代吡唑类化合物的盐为通式I-A或I-B所示的化合物与盐酸、硫酸、磷酸、甲酸、乙酸、三氟乙酸、草酸、甲磺酸、对甲苯磺酸、苯甲酸、邻苯二甲酸、马来酸、富马酸、山梨酸、苹果酸或柠檬酸形成的盐；
    活性组分B选自呼吸抑制剂类杀菌剂、核酸代谢抑制剂类杀菌剂、细胞壁合成抑制剂类杀菌剂、信号传导作用抑制剂类杀菌剂、细胞骨架和运动蛋白抑制剂类杀菌剂、固醇生物合成抑制剂类杀菌剂、磷脂合成抑制剂类杀菌剂、甲硫氨酸生物合成抑制剂类杀菌剂、多位点抑制剂类杀菌剂、作用机制未知类杀菌剂中的一种或几种。
  3. 根据权利要求1或2所述的杀菌组合物，其特征在于：所述组合物为按重量比为1:50-50:1的活性组分A和活性组分B；
    其中，活性组分A选自通式I-A中的化合物或其盐中的一种或几种；
    式中：R 3选自氢、羟基、甲酰基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷硫基、C 2-C 4烯基硫基、C 2-C 4烯基、C 2-C 4炔基、卤代C 2-C 4烯基或卤代C 2-C 4炔基；R 4、R 5可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 6、R 7可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 8、R 9可相同或不同，分别选自氢、氰基、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基羰基或卤代C 1-C 4烷氧基羰基；R 11选自卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷基氨基、卤代C 1-C 4烷基氨基、二(C 1-C 4烷基)氨基、卤代二(C 1-C 4烷基)氨基或C 1-C 4烷硫基；n选自0至5的整数，当n为0时，苯环上无取代基；当n大于1时，R 11可相同或不同；R 14、R 15、R 16或R 17可相同或不同，分别选自氢、卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基或C 1-C 4烷氧基；W选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基或C 1-C 4烷硫基；
    所述通式I-A所示化合物的盐为通式化合物与盐酸、硫酸、磷酸、甲酸、乙酸、三氟乙酸、草酸、甲磺酸、对甲苯磺酸、苯甲酸、邻苯二甲酸或马来酸形成的盐；
    活性组分B选自苯并烯氟菌唑(benzovindiflupyr)B1、氟唑菌苯胺(penflufen)B2、吡唑萘菌胺(isopyrazam)B3、氟唑菌酰胺(fluxapyroxad)B4、氟吡菌酰胺(fluopyram)B5、氟苯醚酰胺(flubeneteram)B6、氟唑环菌胺(sedaxane)B7、吡噻菌胺 (penthiopyrad)B8、啶酰菌胺(boscalid)B9、联苯吡菌胺(bixafen)B10、氟酰胺(flutolanil)B11、呋吡菌胺(furametpyr)B12、噻呋酰胺(thifluzamide)B13、氟唑菌酰羟胺(pydiflumetofen)B14、氟茚唑菌胺(fluindapyr)B15、氟醚菌酰胺(fluopimomide)B16、异丙噻菌胺(isofetamid)B17、inpyrfluxam B18、isoflucypram B19、pyraziflumid B20、pyrapropoyne B21、萎锈灵(carboxin)B22、氧化萎锈灵(oxycarboxin)B23、甲呋酰胺(fenfuram)B24、灭锈胺(mepronil)B25、麦锈灵(benodanil)B26、氟吡菌胺(fluopicolide)B27、咪唑菌酮(fenamidone)B28、噁唑菌酮(famoxadone)B29、氰霜唑(cyazofamid)B30、唑嘧菌胺(ametoctradin)B31、氟啶胺(fluazinam)B32、fenpicoxamid B33、florylpicoxamid B34、吲唑磺菌胺(amisulbrom)B35、硅噻菌胺(silthiopham)B36、吡菌苯威(pyribencarb)B37、三苯基氯化锡(triphenyltin chloride)B38、二硝巴豆酸酯(cincxap)B39、敌螨普(dinocap)B40、氟吗啉(flumorph)B41、烯酰吗啉(dimethomorph)B42、双炔酰菌胺(mandipropamid)B43、苯酰菌胺(zoxamide)B44、甲霜灵(metalaxyl)B45、精甲霜灵(metalaxyl-M)B46、异丙菌胺(iprovalicarb)B47、霜脲氰(cymoxanil)B48、精苯霜灵(benalaxyl-M)B49、磺菌胺(flusulfamide)B50、噻酰菌胺(tiadinil)B51、噻唑菌胺(ethaboxam)B52、环氟菌胺(cyflufenamid)B53、环酰菌胺(fenhexamid)B54、双氯氰菌胺(diclocymet)B55、乙嘧酚磺酸酯(bupirimate)B56、二甲嘧酚(dimethirimol)B57、乙嘧酚(ethirimol)B58、噁霉灵(hymexazol)B59、辛噻酮(octhilinone)B60、呋酰胺(ofurace)B61、喹菌酮(chinomethionat)B62、噁霜灵(metidaxyl)B63、呋霜灵(furalaxyl)B64、咯菌腈(fludioxonil)B65、拌种咯(fenpicloni)B66、异菌脲(iprodione)B67、腐霉利(procymidone)B68、甲菌利(meclozolin)B69、乙菌利(chlozolinate)B70、菌核净(dimethachlon)B71、乙烯菌核利(vinclozolin)B72、乙霉威(diethofencarb)B73、苯菌酮(metrafenone)B74、pyriofenone B75、多菌灵(carbendazim)B76、甲基硫菌灵(thiophanate-methyl)B77、氰烯菌酯(phenamacril)B78、苯菌灵(benomyl)B79、麦穗宁(fuberidazole)B80、噻菌灵(thiabendazole)B81、硫菌灵(thiophanate)B82、戊菌隆(pencycuron)B83、乙环唑(etaconazole)B84、啶斑肟(ethanone)B85、氯苯嘧啶醇(fenarimol)B86、腈苯唑(fenbuconazole)B87、苯锈啶(fenpropidine)B88、丁苯吗啉(fenpropimorph)B89、胺苯吡菌酮(fenpyrazamine)B90、氯氟醚菌唑(mefentrifluconazole)B91、氟苯嘧啶醇(nuarimol)B92、恶咪唑(oxpoconazole)B93、稻瘟酯(pefurazoate)B94、咪鲜胺(prochloraz)B95、螺环菌胺(spiroxamine) B96、啶菌噁唑(pyrisoxazole)B97、十三吗啉(tridemorph)B98、嗪氨灵(triforine)B99、十二环吗啉(dodemorph)B100、糠菌唑(bromuconazole)B101、抑芽唑(triapenthenol)B102、萘替芬(naftifine)B103、硅氟唑(simeconazole)B104、氟菌唑(triflumizole)B105、ipfentrifluconazole B106、四氯硝基苯(tecnazene)B107、地茂散(chloroneb)B108、氯硝胺(dicloran)B109、联苯(biphenyl)B110、敌瘟磷(edifenphos)B111、土菌灵(etridiazole)B112、碘代丙炔基丁基甲胺酸酯(iodocarb)B113、异稻瘟净(iprobenfos)B114、稻瘟灵(isoprothiolane)B115、氟噻唑吡乙酮(oxathiapiprolin)B116、fluoxapiproline B117、霜霉威(propamocarb)B118、硫菌威(prothiocarb)B119、吡菌磷(pyrazophos)B120、五氯硝基苯(quintozene)B121、甲基立枯磷(tolclofos-methyl)B122、苯噻菌胺(benthiavalicarb-isopropyl)B123、多抗霉素(polyoxin)B124、缬菌胺(valifenalate)B125、丁吡吗啉(pyrimorph)B126、灭瘟素(blasticidin-s)B127、嘧菌环胺(cyprodinil)B128、春雷霉素(kasugamycin)B129、嘧菌胺(mepanipyrim)B130、嘧霉胺(pyrimethanil)B131、链霉素(streptomycin)B132、土霉素(oxytetracycline)B133、代森锌(zineb)B134、代森锰锌(mancozeb)B135、代森联(metiram)B136、丙森锌(propineb)B137、代森锰(maneb)B138、代森铵(amobam)B139、代森钠(nabam)B140、代森硫(etem)B141、代森环(milneb)B142、代森锰铜(mancopper)B143、呋菌清(cufraneb)B144、硫黄(sulphur)B145、敌菌灵(anilazine)B146、克菌丹(captan)B147、灭螨猛(chinomethionat)B148、百菌清(chlorothalonil)B149、苯氟磺胺(dichlofluanid)B150、甲苯氟磺胺(tolylfluanid)B151、二氰蒽醌(dithianon)B152、氟酰亚胺(fluoroimide)B153、磺菌威(methasulfocarb)B154、敌菌丹(captafol)B155、灭菌丹(folpet)B156、双胍辛胺(iminoctadine)B157、双胍盐(guazatine)B158、噻唑锌(zinc thiazole)B159、喹啉铜(oxine-copper)B160、噻菌铜(thiodiazole-copper)B161、壬菌铜(cuppric nonyl phenolsulfonate)B162、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165、多果定(dodine)B166、pyridachlometyl B167、哒菌酮(diclomezine)B168、井冈霉素(validamycin)B169、嘧菌腙(ferimzone)B170、tebufloquin B171、咪唑嗪(triazoxide)B172、quinofumelin B173、ipflufenoquin B174、dipymetitrone B175、teclofthalam B176中的一种或几种。
  4. 根据权利要求3所述的杀菌组合物，其特征在于：所述组合物为按重量比为1:20-20:1的活性组分A和活性组分B；
    其中，活性组分A为通式I-A所示化合物或其盐中的一种或几种；
    式中，R 3选自氢、羟基、甲酰基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷硫基、C 2-C 4烯基硫基、C 2-C 4烯基、C 2-C 4炔基、卤代C 2-C 4烯基或卤代C 2-C 4炔基；R 4、R 5可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 6、R 7可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 8、R 9可相同或不同，分别选自氢、氰基、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基羰基或卤代C 1-C 4烷氧基羰基；R 11选自卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷基氨基或卤代C 1-C 4烷基氨基；n选自0至5的整数，当n为0时，苯环上无取代基；当n大于1时，R 11可相同或不同；R 14、R 15、R 16或R 17可相同或不同，分别选自氢、卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；W选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基或C 1-C 4烷硫基；
    所述通式I-A所示化合物的盐为通式化合物与盐酸、硫酸、磷酸、甲酸、乙酸、三氟乙酸、草酸或甲磺酸形成的盐；
    活性组分B选自苯并烯氟菌唑(benzovindiflupyr)B1、氟唑菌苯胺(penflufen)B2、吡唑萘菌胺(isopyrazam)B3、氟唑菌酰胺(fluxapyroxad)B4、氟吡菌酰胺(fluopyram)B5、氟苯醚酰胺(flubeneteram)B6、氟唑环菌胺(sedaxane)B7、吡噻菌胺(penthiopyrad)B8、啶酰菌胺(boscalid)B9、联苯吡菌胺(bixafen)B10、氟酰胺(flutolanil)B11、呋吡菌胺(furametpyr)B12、噻呋酰胺(thifluzamide)B13、氟唑菌酰羟胺(pydiflumetofen)B14、氟茚唑菌胺(fluindapyr)B15、氟醚菌酰胺(fluopimomide)B16、异丙噻菌胺(isofetamid)B17、inpyrfluxam B18、isoflucypram B19、pyraziflumid B20、pyrapropoyne B21、麦锈灵(benodanil)B26、氟吡菌胺(fluopicolide)B27、咪唑菌酮(fenamidone)B28、噁唑菌酮(famoxadone)B29、氰霜唑(cyazofamid)B30、唑嘧菌胺(ametoctradin)B31、氟啶胺(fluazinam)B32、fenpicoxamid B33、florylpicoxamid B34、吲唑磺菌胺(amisulbrom)B35、硅噻菌胺(silthiopham)B36、吡菌苯威(pyribencarb)B37、氟吗啉(flumorph)B41、烯酰吗啉(dimethomorph)B42、双炔酰菌胺(mandipropamid)B43、苯酰菌胺(zoxamide)B44、精甲霜灵(metalaxyl-M)B46、异丙菌胺(iprovalicarb)B47、霜脲氰(cymoxanil)B48、精苯霜灵(benalaxyl-M)B49、噻酰菌胺(tiadinil)B51、噻唑菌胺(ethaboxam)B52、乙嘧酚磺酸酯(bupirimate)B56、二甲嘧酚(dimethirimol)B57、乙嘧酚 (ethirimol)B58、噁霉灵(hymexazol)B59、辛噻酮(octhilinone)B60、呋酰胺(ofurace)B61、喹菌酮(chinomethionat)B62、咯菌腈(fludioxonil)B65、拌种咯(fenpicloni)B66、异菌脲(iprodione)B67、腐霉利(procymidone)B68、菌核净(dimethachlon)B71、乙烯菌核利(vinclozolin)B72、乙霉威(diethofencarb)B73、苯菌酮(metrafenone)B74、pyriofenone B75、多菌灵(carbendazim)B76、甲基硫菌灵(thiophanate-methyl)B77、氰烯菌酯(phenamacril)B78、苯菌灵(benomyl)B79、啶斑肟(ethanone)B85、氯苯嘧啶醇(fenarimol)B86、腈苯唑(fenbuconazole)B87、苯锈啶(fenpropidine)B88、胺苯吡菌酮(fenpyrazamine)B90、氯氟醚菌唑(mefentrifluconazole)B91、氟苯嘧啶醇(nuarimol)B92、恶咪唑(oxpoconazole)B93、稻瘟酯(pefurazoate)B94、咪鲜胺(prochloraz)B95、螺环菌胺(spiroxamine)B96、啶菌噁唑(pyrisoxazole)B97、硅氟唑(simeconazole)B104、ipfentrifluconazole B106、敌瘟磷(edifenphos)B111、异稻瘟净(iprobenfos)B114、稻瘟灵(isoprothiolane)B115、氟噻唑吡乙酮(oxathiapiprolin)B116、fluoxapiproline B117、霜霉威(propamocarb)B118、硫菌威(prothiocarb)B119、吡菌磷(pyrazophos)B120、五氯硝基苯(quintozene)B121、甲基立枯磷(tolclofos-methyl)B122、苯噻菌胺(benthiavalicarb-isopropyl)B123、多抗霉素(polyoxin)B124、缬菌胺(valifenalate)B125、丁吡吗啉(pyrimorph)B126、嘧菌环胺(cyprodinil)B128、春雷霉素(kasugamycin)B129、嘧菌胺(mepanipyrim)B130、嘧霉胺(pyrimethanil)B131、链霉素(streptomycin)B132、代森锌(zineb)B134、代森锰锌(mancozeb)B135、代森联(metiram)B136、丙森锌(propineb)B137、代森锰(maneb)B138、代森铵(amobam)B139、代森环(milneb)B142、代森锰铜(mancopper)B143、硫黄(sulphur)B145、敌菌灵(anilazine)B146、克菌丹(captan)B147、百菌清(chlorothalonil)B149、苯氟磺胺(dichlofluanid)B150、甲苯氟磺胺(tolylfluanid)B151、磺菌威(methasulfocarb)B154、敌菌丹(captafol)B155、灭菌丹(folpet)B156、噻唑锌(zinc thiazole)B159、喹啉铜(oxine-copper)B160、噻菌铜(thiodiazole-copper)B161、壬菌铜(cuppric nonyl phenolsulfonate)B162、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165、pyridachlometyl B167、井冈霉素(validamycin)B169、嘧菌腙(ferimzone)B170、tebufloquin B171、quinofumelin B173、ipflufenoquin B174、dipymetitrone B175、teclofthalam B176中的一种或几种。
  5. 根据权利要求4所述的杀菌组合物，其特征在于：所述组合物为按重量比为1:10-10:1的活性组分A和活性组分B；
    其中，活性组分A选自通式I-A中的化合物或其盐中的一种或几种；
    式中，R 3选自氢、羟基、甲酰基或C 1-C 4烷基；R 4、R 5可相同或不同，分别选自氢、卤素或C 1-C 4烷基；R 6、R 7可相同或不同，分别选自氢、卤素或C 1-C 4烷基；R 8、R 9可相同或不同，分别选自氢、氰基、卤素或C 1-C 4烷基；R 11选自卤素、羟基、氨基、氰基、硝基或C 1-C 4烷基；n选自0至5的整数，当n为0时，苯环上无取代基；当n大于1时，R 11可相同或不同；R 14、R 15、R 16或R 17可相同或不同，分别选自氢、卤素、羟基、氨基、氰基、硝基或C 1-C 4烷基；W选自氢、卤素或C 1-C 4烷基；
    所述通式I-A所示化合物的盐为通式化合物与盐酸、硫酸、磷酸、甲酸或乙酸形成的盐；
    活性组分B选自苯并烯氟菌唑(benzovindiflupyr)B1、氟唑菌苯胺(penflufen)B2、吡唑萘菌胺(isopyrazam)B3、氟唑菌酰胺(fluxapyroxad)B4、氟吡菌酰胺(fluopyram)B5、氟苯醚酰胺(flubeneteram)B6、氟唑环菌胺(sedaxane)B7、吡噻菌胺(penthiopyrad)B8、啶酰菌胺(boscalid)B9、联苯吡菌胺(bixafen)B10、噻呋酰胺(thifluzamide)B13、氟唑菌酰羟胺(pydiflumetofen)B14、氟茚唑菌胺(fluindapyr)B15、氟醚菌酰胺(fluopimomide)B16、inpyrfluxam B18、isoflucypram B19、pyraziflumid B20、pyrapropoyne B21、麦锈灵(benodanil)B26、氟吡菌胺(fluopicolide)B27、咪唑菌酮(fenamidone)B28、噁唑菌酮(famoxadone)B29、氰霜唑(cyazofamid)B30、唑嘧菌胺(ametoctradin)B31、氟啶胺(fluazinam)B32、fenpicoxamid B33、florylpicoxamid B34、硅噻菌胺(silthiopham)B36、氟吗啉(flumorph)B41、烯酰吗啉(dimethomorph)B42、双炔酰菌胺(mandipropamid)B43、苯酰菌胺(zoxamide)B44、精甲霜灵(metalaxyl-M)B46、异丙菌胺(iprovalicarb)B47、霜脲氰(cymoxanil)B48、噻酰菌胺(tiadinil)B51、噻唑菌胺(ethaboxam)B52、乙嘧酚磺酸酯(bupirimate)B56、乙嘧酚(ethirimol)B58、噁霉灵(hymexazol)B59、辛噻酮(octhilinone)B60、喹菌酮(chinomethionat)B62、咯菌腈(fludioxonil)B65、异菌脲(iprodione)B67、腐霉利(procymidone)B68、乙霉威(diethofencarb)B73、苯菌酮(metrafenone)B74、pyriofenone B75、多菌灵(carbendazim)B76、甲基硫菌灵(thiophanate-methyl)B77、氰烯菌酯(phenamacril)B78、腈苯唑(fenbuconazole)B87、氯氟醚菌唑(mefentrifluconazole)B91、氟苯嘧啶醇(nuarimol)B92、咪鲜胺(prochloraz)B95、螺环菌胺(spiroxamine)B96、啶菌噁唑(pyrisoxazole)B97、硅氟唑(simeconazole)B104、ipfentrifluconazole B106、异稻瘟净(iprobenfos) B114、稻瘟灵(isoprothiolane)B115、氟噻唑吡乙酮(oxathiapiprolin)B116、fluoxapiproline B117、霜霉威(propamocarb)B118、五氯硝基苯(quintozene)B121、甲基立枯磷(tolclofos-methyl)B122、苯噻菌胺(benthiavalicarb-isopropyl)B123、多抗霉素(polyoxin)B124、缬菌胺(valifenalate)B125、丁吡吗啉(pyrimorph)B126、嘧菌环胺(cyprodinil)B128、春雷霉素(kasugamycin)B129、嘧霉胺(pyrimethanil)B131、链霉素(streptomycin)B132、代森锌(zineb)B134、代森锰锌(mancozeb)B135、代森联(metiram)B136、丙森锌(propineb)B137、硫黄(sulphur)B145、克菌丹(captan)B147、百菌清(chlorothalonil)B149、苯氟磺胺(dichlofluanid)B150、敌菌丹(captafol)B155、灭菌丹(folpet)B156、噻唑锌(zinc thiazole)B159、喹啉铜(oxine-copper)B160、噻菌铜(thiodiazole-copper)B161、壬菌铜(cuppric nonyl phenolsulfonate)B162、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165、pyridachlometyl B167、井冈霉素(validamycin)B169、tebufloquin B171、quinofumelin B173、ipflufenoquin B174、dipymetitrone B175、teclofthalam B176中的一种或几种。
  6. 根据权利要求1或2所述的杀菌组合物，其特征在于：所述组合物为按重量比为1:50-50:1的活性组分A和活性组分B；
    其中，活性组分A选自通式I-B中的化合物或其盐中的一种或几种；
    式中，R 1选自氢、卤素、氰基、硝基、氨基、羧基、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 1-C 4烷硫基、卤代C 1-C 4烷硫基、C 1-C 4烷基亚磺酰基、C 1-C 4烷基磺酰基、C 2-C 4烯基、卤代C 2-C 4烯基、C 2-C 4炔基或卤代C 2-C 4炔基；R 2选自氢、卤素、氰基、硝基、氨基、羧基、甲酰基、C 1-C 4烷基或卤代C 1-C 4烷基；R 3选自氢、羟基、甲酰基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷硫基、C 2-C 4烯基硫基、C 2-C 4烯基、C 2-C 4炔基、卤代C 2-C 4烯基或卤代C 2-C 4炔基；R 4、R 5可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 6、R 7可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 8、R 9可相同或不同，分别选自氢、氰基、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基羰基或卤代C 1-C 4烷氧基羰基；R 11选自卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷基氨基、卤代C 1-C 4烷基氨基、二(C 1-C 4烷基)氨基、卤代二(C 1-C 4烷基)氨基或C 1-C 4烷硫基；n选自0至5的整数，当n为0时，苯 环上无取代基；当n大于1时，R 11可相同或不同；W选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基或C 1-C 4烷硫基；
    所述通式I-B所示化合物的盐为通式化合物与盐酸、硫酸、磷酸、甲酸、乙酸、三氟乙酸、草酸、甲磺酸、对甲苯磺酸、苯甲酸、邻苯二甲酸或马来酸形成的盐；
    活性组分B选自苯并烯氟菌唑(benzovindiflupyr)B1、氟唑菌苯胺(penflufen)B2、吡唑萘菌胺(isopyrazam)B3、氟唑菌酰胺(fluxapyroxad)B4、氟吡菌酰胺(fluopyram)B5、氟苯醚酰胺(flubeneteram)B6、氟唑环菌胺(sedaxane)B7、吡噻菌胺(penthiopyrad)B8、啶酰菌胺(boscalid)B9、联苯吡菌胺(bixafen)B10、氟酰胺(flutolanil)B11、呋吡菌胺(furametpyr)B12、噻呋酰胺(thifluzamide)B13、氟唑菌酰羟胺(pydiflumetofen)B14、氟茚唑菌胺(fluindapyr)B15、氟醚菌酰胺(fluopimomide)B16、异丙噻菌胺(isofetamid)B17、inpyrfluxam B18、isoflucypram B19、pyraziflumid B20、pyrapropoyne B21、萎锈灵(carboxin)B22、氧化萎锈灵(oxycarboxin)B23、甲呋酰胺(fenfuram)B24、灭锈胺(mepronil)B25、麦锈灵(benodanil)B26、氟吡菌胺(fluopicolide)B27、咪唑菌酮(fenamidone)B28、噁唑菌酮(famoxadone)B29、氰霜唑(cyazofamid)B30、唑嘧菌胺(ametoctradin)B31、氟啶胺(fluazinam)B32、fenpicoxamid B33、florylpicoxamid B34、吲唑磺菌胺(amisulbrom)B35、硅噻菌胺(silthiopham)B36、吡菌苯威(pyribencarb)B37、三苯基氯化锡(triphenyltin chloride)B38、二硝巴豆酸酯(cincxap)B39、敌螨普(dinocap)B40、氟吗啉(flumorph)B41、烯酰吗啉(dimethomorph)B42、双炔酰菌胺(mandipropamid)B43、苯酰菌胺(zoxamide)B44、甲霜灵(metalaxyl)B45、精甲霜灵(metalaxyl-M)B46、异丙菌胺(iprovalicarb)B47、霜脲氰(cymoxanil)B48、精苯霜灵(benalaxyl-M)B49、磺菌胺(flusulfamide)B50、噻酰菌胺(tiadinil)B51、噻唑菌胺(ethaboxam)B52、环氟菌胺(cyflufenamid)B53、环酰菌胺(fenhexamid)B54、双氯氰菌胺(diclocymet)B55、乙嘧酚磺酸酯(bupirimate)B56、二甲嘧酚(dimethirimol)B57、乙嘧酚(ethirimol)B58、噁霉灵(hymexazol)B59、辛噻酮(octhilinone)B60、呋酰胺(ofurace)B61、喹菌酮(chinomethionat)B62、噁霜灵(metidaxyl)B63、呋霜灵(furalaxyl)B64、咯菌腈(fludioxonil)B65、拌种咯(fenpicloni)B66、异菌脲(iprodione)B67、腐霉利(procymidone)B68、甲菌利(meclozolin)B69、乙菌利(chlozolinate)B70、菌核净(dimethachlon)B71、乙烯菌核利(vinclozolin)B72、乙霉威(diethofencarb)B73、苯菌酮 (metrafenone)B74、pyriofenone B75、多菌灵(carbendazim)B76、甲基硫菌灵(thiophanate-methyl)B77、氰烯菌酯(phenamacril)B78、苯菌灵(benomyl)B79、麦穗宁(fuberidazole)B80、噻菌灵(thiabendazole)B81、硫菌灵(thiophanate)B82、戊菌隆(pencycuron)B83、乙环唑(etaconazole)B84、啶斑肟(ethanone)B85、氯苯嘧啶醇(fenarimol)B86、腈苯唑(fenbuconazole)B87、苯锈啶(fenpropidine)B88、丁苯吗啉(fenpropimorph)B89、胺苯吡菌酮(fenpyrazamine)B90、氯氟醚菌唑(mefentrifluconazole)B91、氟苯嘧啶醇(nuarimol)B92、恶咪唑(oxpoconazole)B93、稻瘟酯(pefurazoate)B94、咪鲜胺(prochloraz)B95、螺环菌胺(spiroxamine)B96、啶菌噁唑(pyrisoxazole)B97、十三吗啉(tridemorph)B98、嗪氨灵(triforine)B99、十二环吗啉(dodemorph)B100、糠菌唑(bromuconazole)B101、抑芽唑(triapenthenol)B102、萘替芬(naftifine)B103、硅氟唑(simeconazole)B104、氟菌唑(triflumizole)B105、ipfentrifluconazole B106、四氯硝基苯(tecnazene)B107、地茂散(chloroneb)B108、氯硝胺(dicloran)B109、联苯(biphenyl)B110、敌瘟磷(edifenphos)B111、土菌灵(etridiazole)B112、碘代丙炔基丁基甲胺酸酯(iodocarb)B113、异稻瘟净(iprobenfos)B114、稻瘟灵(isoprothiolane)B115、氟噻唑吡乙酮(oxathiapiprolin)B116、fluoxapiproline B117、霜霉威(propamocarb)B118、硫菌威(prothiocarb)B119、吡菌磷(pyrazophos)B120、五氯硝基苯(quintozene)B121、甲基立枯磷(tolclofos-methyl)B122、苯噻菌胺(benthiavalicarb-isopropyl)B123、多抗霉素(polyoxin)B124、缬菌胺(valifenalate)B125、丁吡吗啉(pyrimorph)B126、灭瘟素(blasticidin-s)B127、嘧菌环胺(cyprodinil)B128、春雷霉素(kasugamycin)B129、嘧菌胺(mepanipyrim)B130、嘧霉胺(pyrimethanil)B131、链霉素(streptomycin)B132、土霉素(oxytetracycline)B133、代森锌(zineb)B134、代森锰锌(mancozeb)B135、代森联(metiram)B136、丙森锌(propineb)B137、代森锰(maneb)B138、代森铵(amobam)B139、代森钠(nabam)B140、代森硫(etem)B141、代森环(milneb)B142、代森锰铜(mancopper)B143、呋菌清(cufraneb)B144、硫黄(sulphur)B145、敌菌灵(anilazine)B146、克菌丹(captan)B147、灭螨猛(chinomethionat)B148、百菌清(chlorothalonil)B149、苯氟磺胺(dichlofluanid)B150、甲苯氟磺胺(tolylfluanid)B151、二氰蒽醌(dithianon)B152、氟酰亚胺(fluoroimide)B153、磺菌威(methasulfocarb)B154、敌菌丹(captafol)B155、灭菌丹(folpet)B156、双胍辛胺(iminoctadine)B157、双胍盐(guazatine)B158、噻唑锌(zinc thiazole)B159、喹啉铜(oxine-copper) B160、噻菌铜(thiodiazole-copper)B161、壬菌铜(cuppric nonyl phenolsulfonate)B162、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165、多果定(dodine)B166、pyridachlometyl B167、哒菌酮(diclomezine)B168、井冈霉素(validamycin)B169、嘧菌腙(ferimzone)B170、tebufloquin B171、咪唑嗪(triazoxide)B172、quinofumelin B173、ipflufenoquin B174、dipymetitrone B175、teclofthalam B176中的一种或几种。
  7. 根据权利要求6所述的杀菌组合物，其特征在于：所述组合物为按重量比为1:20-20:1的活性组分A和活性组分B；
    其中，活性组分A选自通式I-B中的化合物或其盐中的一种或几种；
    式中，R 1选自氢、卤素、氰基、硝基、氨基、羧基、C 1-C 4烷基或卤代C 1-C 4烷基；R 2选自氢、卤素、氰基、硝基、氨基、羧基、甲酰基、C 1-C 4烷基或卤代C 1-C 4烷基；R 3选自氢、羟基、甲酰基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷硫基、C 2-C 4烯基硫基、C 2-C 4烯基、C 2-C 4炔基、卤代C 2-C 4烯基或卤代C 2-C 4炔基；R 4、R 5可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 6、R 7可相同或不同，分别选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基或卤代C 1-C 4烷氧基；R 8、R 9可相同或不同，分别选自氢、氰基、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基羰基或卤代C 1-C 4烷氧基羰基；R 11选自卤素、羟基、氨基、氰基、硝基、C 1-C 4烷基、卤代C 1-C 4烷基、C 1-C 4烷氧基、卤代C 1-C 4烷氧基、C 3-C 4环烷基、C 1-C 4烷基氨基或卤代C 1-C 4烷基氨基；n选自0至5的整数，当n为0时，苯环上无取代基；当n大于1时，R 11可相同或不同；W选自氢、卤素、C 1-C 4烷基、卤代C 1-C 4烷基、C 3-C 4环烷基、C 1-C 4烷氧基或C 1-C 4烷硫基；
    所述通式I-B所示化合物的盐为通式化合物与盐酸、硫酸、磷酸、甲酸、乙酸、三氟乙酸、草酸或甲磺酸形成的盐；
    活性组分B选自苯并烯氟菌唑(benzovindiflupyr)B1、氟唑菌苯胺(penflufen)B2、吡唑萘菌胺(isopyrazam)B3、氟唑菌酰胺(fluxapyroxad)B4、氟吡菌酰胺(fluopyram)B5、氟苯醚酰胺(flubeneteram)B6、氟唑环菌胺(sedaxane)B7、吡噻菌胺(penthiopyrad)B8、啶酰菌胺(boscalid)B9、联苯吡菌胺(bixafen)B10、氟酰胺(flutolanil)B11、呋吡菌胺(furametpyr)B12、噻呋酰胺(thifluzamide)B13、氟唑菌酰羟胺(pydiflumetofen)B14、氟茚唑菌胺(fluindapyr)B15、氟醚菌酰胺(fluopimomide)B16、异丙噻菌胺(isofetamid)B17、inpyrfluxam B18、isoflucypram B19、pyraziflumid  B20、pyrapropoyne B21、麦锈灵(benodanil)B26、氟吡菌胺(fluopicolide)B27、咪唑菌酮(fenamidone)B28、噁唑菌酮(famoxadone)B29、氰霜唑(cyazofamid)B30、唑嘧菌胺(ametoctradin)B31、氟啶胺(fluazinam)B32、fenpicoxamid B33、florylpicoxamid B34、吲唑磺菌胺(amisulbrom)B35、硅噻菌胺(silthiopham)B36、吡菌苯威(pyribencarb)B37、氟吗啉(flumorph)B41、烯酰吗啉(dimethomorph)B42、双炔酰菌胺(mandipropamid)B43、苯酰菌胺(zoxamide)B44、精甲霜灵(metalaxyl-M)B46、异丙菌胺(iprovalicarb)B47、霜脲氰(cymoxanil)B48、精苯霜灵(benalaxyl-M)B49、噻酰菌胺(tiadinil)B51、噻唑菌胺(ethaboxam)B52、乙嘧酚磺酸酯(bupirimate)B56、二甲嘧酚(dimethirimol)B57、乙嘧酚(ethirimol)B58、噁霉灵(hymexazol)B59、辛噻酮(octhilinone)B60、呋酰胺(ofurace)B61、喹菌酮(chinomethionat)B62、咯菌腈(fludioxonil)B65、拌种咯(fenpicloni)B66、异菌脲(iprodione)B67、腐霉利(procymidone)B68、菌核净(dimethachlon)B71、乙烯菌核利(vinclozolin)B72、乙霉威(diethofencarb)B73、苯菌酮(metrafenone)B74、pyriofenone B75、多菌灵(carbendazim)B76、甲基硫菌灵(thiophanate-methyl)B77、氰烯菌酯(phenamacril)B78、苯菌灵(benomyl)B79、啶斑肟(ethanone)B85、氯苯嘧啶醇(fenarimol)B86、腈苯唑(fenbuconazole)B87、苯锈啶(fenpropidine)B88、胺苯吡菌酮(fenpyrazamine)B90、氯氟醚菌唑(mefentrifluconazole)B91、氟苯嘧啶醇(nuarimol)B92、恶咪唑(oxpoconazole)B93、稻瘟酯(pefurazoate)B94、咪鲜胺(prochloraz)B95、螺环菌胺(spiroxamine)B96、啶菌噁唑(pyrisoxazole)B97、硅氟唑(simeconazole)B104、ipfentrifluconazole B106、敌瘟磷(edifenphos)B111、异稻瘟净(iprobenfos)B114、稻瘟灵(isoprothiolane)B115、氟噻唑吡乙酮(oxathiapiprolin)B116、fluoxapiproline B117、霜霉威(propamocarb)B118、硫菌威(prothiocarb)B119、吡菌磷(pyrazophos)B120、五氯硝基苯(quintozene)B121、甲基立枯磷(tolclofos-methyl)B122、苯噻菌胺(benthiavalicarb-isopropyl)B123、多抗霉素(polyoxin)B124、缬菌胺(valifenalate)B125、丁吡吗啉(pyrimorph)B126、嘧菌环胺(cyprodinil)B128、春雷霉素(kasugamycin)B129、嘧菌胺(mepanipyrim)B130、嘧霉胺(pyrimethanil)B131、链霉素(streptomycin)B132、代森锌(zineb)B134、代森锰锌(mancozeb)B135、代森联(metiram)B136、丙森锌(propineb)B137、代森锰(maneb)B138、代森铵(amobam)B139、代森环(milneb)B142、代森锰铜(mancopper)B143、硫黄(sulphur)B145、敌菌灵(anilazine)B146、克菌丹(captan)B147、百菌清(chlorothalonil)B149、苯 氟磺胺(dichlofluanid)B150、甲苯氟磺胺(tolylfluanid)B151、磺菌威(methasulfocarb)B154、敌菌丹(captafol)B155、灭菌丹(folpet)B156、噻唑锌(zinc thiazole)B159、喹啉铜(oxine-copper)B160、噻菌铜(thiodiazole-copper)B161、壬菌铜(cuppric nonyl phenolsulfonate)B162、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165、pyridachlometyl B167、井冈霉素(validamycin)B169、嘧菌腙(ferimzone)B170、tebufloquin B171、quinofumelin B173、ipflufenoquin B174、dipymetitrone B175、teclofthalam B176中的一种或几种。
  8. 根据权利要求7所述的杀菌组合物，其特征在于：所述组合物为按重量比为1:10-10:1的活性组分A和活性组分B；
    其中，活性组分A选自通式I-B中的化合物或其盐中的一种或几种；
    式中，R 1选自氢、卤素、氰基、硝基、氨基、羧基或C 1-C 4烷基；R 2选自氢、卤素、氰基、硝基、氨基、羧基、甲酰基或C 1-C 4烷基；R 3选自氢、羟基、甲酰基或C 1-C 4烷基；R 4、R 5可相同或不同，分别选自氢、卤素或C 1-C 4烷基；R 6、R 7可相同或不同，分别选自氢、卤素或C 1-C 4烷基；R 8、R 9可相同或不同，分别选自氢、氰基、卤素或C 1-C 4烷基；R 11选自卤素、羟基、氨基、氰基、硝基或C 1-C 4烷基；n选自0至5的整数，当n为0时，苯环上无取代基；当n大于1时，R 11可相同或不同；W选自氢、卤素或C 1-C 4烷基；
    所述通式I-B所示化合物的盐为通式化合物与盐酸、硫酸、磷酸、甲酸或乙酸形成的盐；
    活性组分B选自苯并烯氟菌唑(benzovindiflupyr)B1、氟唑菌苯胺(penflufen)B2、吡唑萘菌胺(isopyrazam)B3、氟唑菌酰胺(fluxapyroxad)B4、氟吡菌酰胺(fluopyram)B5、氟苯醚酰胺(flubeneteram)B6、氟唑环菌胺(sedaxane)B7、吡噻菌胺(penthiopyrad)B8、啶酰菌胺(boscalid)B9、联苯吡菌胺(bixafen)B10、噻呋酰胺(thifluzamide)B13、氟唑菌酰羟胺(pydiflumetofen)B14、氟茚唑菌胺(fluindapyr)B15、氟醚菌酰胺(fluopimomide)B16、inpyrfluxam B18、isoflucypram B19、pyraziflumid B20、pyrapropoyne B21、麦锈灵(benodanil)B26、氟吡菌胺(fluopicolide)B27、咪唑菌酮(fenamidone)B28、噁唑菌酮(famoxadone)B29、氰霜唑(cyazofamid)B30、唑嘧菌胺(ametoctradin)B31、氟啶胺(fluazinam)B32、fenpicoxamid B33、florylpicoxamid B34、硅噻菌胺(silthiopham)B36、氟吗啉(flumorph)B41、烯酰吗啉(dimethomorph)B42、双炔酰菌胺(mandipropamid)B43、苯酰菌胺(zoxamide)B44、精甲霜灵(metalaxyl-M)B46、异丙菌胺(iprovalicarb)B47、霜脲 氰(cymoxanil)B48、噻酰菌胺(tiadinil)B51、噻唑菌胺(ethaboxam)B52、乙嘧酚磺酸酯(bupirimate)B56、乙嘧酚(ethirimol)B58、噁霉灵(hymexazol)B59、辛噻酮(octhilinone)B60、喹菌酮(chinomethionat)B62、咯菌腈(fludioxonil)B65、异菌脲(iprodione)B67、腐霉利(procymidone)B68、乙霉威(diethofencarb)B73、苯菌酮(metrafenone)B74、pyriofenone B75、多菌灵(carbendazim)B76、甲基硫菌灵(thiophanate-methyl)B77、氰烯菌酯(phenamacril)B78、腈苯唑(fenbuconazole)B87、氯氟醚菌唑(mefentrifluconazole)B91、氟苯嘧啶醇(nuarimol)B92、咪鲜胺(prochloraz)B95、螺环菌胺(spiroxamine)B96、啶菌噁唑(pyrisoxazole)B97、硅氟唑(simeconazole)B104、ipfentrifluconazole B106、异稻瘟净(iprobenfos)B114、稻瘟灵(isoprothiolane)B115、氟噻唑吡乙酮(oxathiapiprolin)B116、fluoxapiproline B117、霜霉威(propamocarb)B118、五氯硝基苯(quintozene)B121、甲基立枯磷(tolclofos-methyl)B122、苯噻菌胺(benthiavalicarb-isopropyl)B123、多抗霉素(polyoxin)B124、缬菌胺(valifenalate)B125、丁吡吗啉(pyrimorph)B126、嘧菌环胺(cyprodinil)B128、春雷霉素(kasugamycin)B129、嘧霉胺(pyrimethanil)B131、链霉素(streptomycin)B132、代森锌(zineb)B134、代森锰锌(mancozeb)B135、代森联(metiram)B136、丙森锌(propineb)B137、硫黄(sulphur)B145、克菌丹(captan)B147、百菌清(chlorothalonil)B149、苯氟磺胺(dichlofluanid)B150、敌菌丹(captafol)B155、灭菌丹(folpet)B156、噻唑锌(zinc thiazole)B159、喹啉铜(oxine-copper)B160、噻菌铜(thiodiazole-copper)B161、壬菌铜(cuppric nonyl phenolsulfonate)B162、picarbutrazox B163、aminopyrifen B164、metyltetraprole B165、pyridachlometyl B167、井冈霉素(validamycin)B169、tebufloquin B171、quinofumelin B173、ipflufenoquin B174、dipymetitrone B175、teclofthalam B176中的一种或几种。
  9. 一种根据权利要求1所述的杀菌组合物的应用，其特征在于：所述杀菌组合物用于制备防治植物病原性真菌、细菌病害的药物。
  10. 根据权利要求6所述的杀菌组合物的应用，其特征在于：所述植物病原性真菌、细菌病害为植物白粉病、锈病、黑星病、叶霉病、纹枯病、立枯病、黑痣病、黑穗病、黑粉病、霜霉病、晚疫病、疫病、霜疫霉病、黑胫病、绵腐病、猝倒病、绵疫病、白锈病、黑斑病、叶斑病、早疫病、炭疽病、褐斑病、蔓枯病、灰霉病、菌核病、腐烂病、根腐病、赤霉病、软腐病、白叶枯病、叶枯病、角斑病、圆斑病、白叶枯病、青枯病、溃疡病或黄龙病。
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2932925A1 (es) * 2021-07-21 2023-01-27 Qiuhua Huang Un uso de composicion bactericida
CN115868396A (zh) * 2022-12-16 2023-03-31 广西南亚热带农业科学研究所 一种澳洲坚果的生态育苗基质
CN115868396B (zh) * 2022-12-16 2024-05-24 广西南亚热带农业科学研究所 一种澳洲坚果的生态育苗基质

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024007376A1 (zh) * 2022-07-05 2024-01-11 浙江省化工研究院有限公司 杀菌组合物及其在防治作物镰刀菌病害中的应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106167484A (zh) * 2015-05-18 2016-11-30 沈阳中化农药化工研发有限公司 含嘧啶的取代吡唑类化合物及其制备方法和用途
CN108059629A (zh) * 2016-11-08 2018-05-22 沈阳中化农药化工研发有限公司 含嘧啶的取代吡唑类化合物及其制备方法和用途
CN109836417A (zh) * 2017-11-29 2019-06-04 沈阳中化农药化工研发有限公司 取代嘧啶类化合物及其制备方法和作为杀菌剂的用途
CN109836418A (zh) * 2017-11-29 2019-06-04 沈阳中化农药化工研发有限公司 取代吡唑类化合物及其制备方法和作为杀虫杀螨剂的用途
CN111316992A (zh) * 2018-12-14 2020-06-23 沈阳中化农药化工研发有限公司 一种杀真菌组合物及应用
CN111316987A (zh) * 2018-12-14 2020-06-23 沈阳中化农药化工研发有限公司 一种杀真菌组合物及其应用
CN111316990A (zh) * 2018-12-14 2020-06-23 沈阳中化农药化工研发有限公司 杀真菌组合物及其应用
CN111316991A (zh) * 2018-12-14 2020-06-23 沈阳中化农药化工研发有限公司 杀真菌组合物及应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0720943B2 (ja) * 1988-08-19 1995-03-08 宇部興産株式会社 アミノピリミジン誘導体、その製法及び殺虫・殺菌剤
AU7551894A (en) * 1993-09-09 1995-03-27 E.I. Du Pont De Nemours And Company Fungicidal, miticidal and arthropodicidal aminopyrimidines

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106167484A (zh) * 2015-05-18 2016-11-30 沈阳中化农药化工研发有限公司 含嘧啶的取代吡唑类化合物及其制备方法和用途
CN108059629A (zh) * 2016-11-08 2018-05-22 沈阳中化农药化工研发有限公司 含嘧啶的取代吡唑类化合物及其制备方法和用途
CN109836417A (zh) * 2017-11-29 2019-06-04 沈阳中化农药化工研发有限公司 取代嘧啶类化合物及其制备方法和作为杀菌剂的用途
CN109836418A (zh) * 2017-11-29 2019-06-04 沈阳中化农药化工研发有限公司 取代吡唑类化合物及其制备方法和作为杀虫杀螨剂的用途
CN111316992A (zh) * 2018-12-14 2020-06-23 沈阳中化农药化工研发有限公司 一种杀真菌组合物及应用
CN111316987A (zh) * 2018-12-14 2020-06-23 沈阳中化农药化工研发有限公司 一种杀真菌组合物及其应用
CN111316990A (zh) * 2018-12-14 2020-06-23 沈阳中化农药化工研发有限公司 杀真菌组合物及其应用
CN111316991A (zh) * 2018-12-14 2020-06-23 沈阳中化农药化工研发有限公司 杀真菌组合物及应用

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2932925A1 (es) * 2021-07-21 2023-01-27 Qiuhua Huang Un uso de composicion bactericida
CN115868396A (zh) * 2022-12-16 2023-03-31 广西南亚热带农业科学研究所 一种澳洲坚果的生态育苗基质
CN115868396B (zh) * 2022-12-16 2024-05-24 广西南亚热带农业科学研究所 一种澳洲坚果的生态育苗基质

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