WO2021104098A1 - 一种神经调控系统及可穿戴神经调控装置 - Google Patents

一种神经调控系统及可穿戴神经调控装置 Download PDF

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Publication number
WO2021104098A1
WO2021104098A1 PCT/CN2020/129213 CN2020129213W WO2021104098A1 WO 2021104098 A1 WO2021104098 A1 WO 2021104098A1 CN 2020129213 W CN2020129213 W CN 2020129213W WO 2021104098 A1 WO2021104098 A1 WO 2021104098A1
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Prior art keywords
stimulation
module
instruction
control module
electrical
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PCT/CN2020/129213
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English (en)
French (fr)
Inventor
罗余
蔚鹏飞
王立平
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中国科学院深圳先进技术研究院
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Publication of WO2021104098A1 publication Critical patent/WO2021104098A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0484—Garment electrodes worn by the patient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/369—Electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6802—Sensor mounted on worn items
    • A61B5/6803—Head-worn items, e.g. helmets, masks, headphones or goggles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36031—Control systems using physiological parameters for adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A61N1/36034—Control systems specified by the stimulation parameters

Definitions

  • This application relates to the technical field of medical circuit devices, and in particular to a nerve control system and a wearable nerve control device.
  • the brain is an organ composed of hundreds of billions of neurons. These neurons form an intertwined neural network.
  • the neural networks transmit and integrate information through the membrane potential of neurons. Therefore, the abnormality of the neural circuit It can also be considered a disorder of the electrical activity of the brain's neural network.
  • scientists have developed a neuromodulation technology that uses an invasive or non-invasive means to regulate the electrical activity of the brain, thereby achieving the purpose of regulating the state of the brain.
  • the technologies that can be used for neural circuit regulation include natural stimulation, drug intervention, electrical, magnetic, and force stimulation, etc., which essentially change the electrical activity of neural networks.
  • natural stimulation is the easiest for patients to accept, with few side effects, but the effect is minimal; drug intervention is the most widely used, but its way of affecting the neural circuit is indirect, and accompanied by greater side effects.
  • Electrical, magnetic, and force stimulation are more direct, especially through external non-invasive stimulation intervention, which can alleviate the suffering of patients.
  • non-invasive transcranial electrical stimulation transcranial Electrical Stimulation, tES
  • tES transcranial Electrical Stimulation
  • This application uses two stimulation modules to directly release electrical stimulation to the scalp, with minimal side effects, but the therapeutic effect is relatively obvious, and multiple stimulation modules can be installed at the same time. It is more efficient to treat multiple brain areas.
  • the first aspect of the application provides a neuromodulation system, which includes the first acquisition module, the first stimulation module, and the second stimulation module electrically connected to the first control module; the first control module receives the acquisition instruction, and The acquisition instruction is sent to the first acquisition module; after the first acquisition module receives the acquisition instruction, the first acquisition module acquires a first EEG signal; after the first EEG signal is diagnosed In the case of abnormality, the first control module receives the first instruction and the second instruction; the first control module sends the first instruction to the first stimulation module, and the first stimulation module receives After the first instruction, the first electrical stimulation is released to the first brain area; the first control module sends the second instruction to the second stimulation module, and the second stimulation module receives the first electrical stimulation. After the second instruction, release the second electrical stimulation to the second brain area.
  • the neuromodulation system as described above further comprising a second control module and a digital isolation unit, the second control module is connected between the first control module and the second stimulation module; the digital isolation unit Connected between the first control module and the second control module;
  • the first control module sends the second instruction to the digital isolation unit; after receiving the second instruction, the digital isolation unit performs galvanic interference isolation processing on the second instruction, and after the isolation processing
  • the second instruction of the isolation process is sent to the second control module; after the second control module receives the isolation process of the second instruction, it sends the isolation process of the second instruction to the second stimulus Module.
  • the neuromodulation system as described above further comprising a wireless module, the wireless module is electrically connected to the first control module; the wireless module is configured to receive the first instruction and the second instruction , Transmitting the first instruction and the second instruction to the first control module.
  • the neuromodulation system as described above further includes a main power supply unit; the main power supply unit is used to supply power to the first acquisition module, the first stimulation module, and the first control module.
  • the main power supply unit is used to provide electrical energy to the auxiliary power supply unit, and the auxiliary power supply unit is used to provide electrical energy to the second control module and the second stimulation module; the main power supply unit transmits the electrical energy to the Power isolation unit; after receiving the electrical energy, the power isolation unit performs galvanic interference isolation processing on the electrical energy, and transmits the isolated electrical energy to the auxiliary power supply unit; the auxiliary power supply unit After receiving the isolated electrical energy source, the isolated electrical energy source is transmitted to the second control module; after the second control module receives the isolated electrical energy source, the isolated electrical energy source is isolated The processed electrical energy source is transmitted to the second stimulation module.
  • the neuromodulation system as described above which further includes a third stimulation module, which is electrically connected to the first control module; when the first brain electrical signal is diagnosed as abnormal, The first control module receives a third instruction; the first control module sends the third instruction to the third stimulation module, and after receiving the third instruction, the third stimulation module sends the third instruction to the third brain Zone releases the third electrical stimulus.
  • a third stimulation module which is electrically connected to the first control module; when the first brain electrical signal is diagnosed as abnormal, The first control module receives a third instruction; the first control module sends the third instruction to the third stimulation module, and after receiving the third instruction, the third stimulation module sends the third instruction to the third brain Zone releases the third electrical stimulus.
  • the neuroregulation system as described above which further includes a second acquisition module that acquires a second EEG signal; when the first EEG signal and the second EEG signal are diagnosed as abnormal
  • the first control module receives the first instruction and the second instruction; the first control module sends the first instruction to the first stimulation module, and the first stimulation module receives the After the first instruction, release the first electrical stimulation to the first brain area; the first control module sends the second instruction to the second stimulation module, and the second stimulation module receives the second instruction Then, the second electrical stimulation is released to the second brain area; or, in the case that the first brain electrical signal is diagnosed as abnormal, the first control module receives the first instruction; in the second brain When the electrical signal is diagnosed as abnormal, the first control module receives the second instruction; the first control module sends the first instruction to the first stimulation module, and the first stimulation module After receiving the first instruction, release the first electrical stimulation to the first brain area; the first control module sends the second instruction to the second stimulation module, and the second stimulation module receives the After the second instruction, the second electrical stimulation
  • first electrical stimulation and the second electrical stimulation are any one of direct current stimulation, sine wave stimulation, square wave stimulation or random noise stimulation; the first electrical stimulation and the second electrical stimulation
  • the maximum amplitude of the electrical stimulation is 1.6 mA; the frequency of the sine wave stimulation and the square wave stimulation is 0 to 1000 Hz, and the adjustment accuracy is 1 Hz.
  • the first acquisition module includes an brain electricity acquisition electrode and a data acquisition unit; the data acquisition unit is electrically connected to the first control module, and the brain electricity acquisition electrode and the The data collection unit is electrically connected; the EEG collection electrode is used to collect the first EEG signal, is used to collect the first EEG signal, and sends the first EEG signal to the data collection unit; the data collection unit receives After the first brain electrical signal is received, the first brain electrical signal is converted into a digital signal and sent to the first control module.
  • the brain electricity collection electrode includes a brain electricity electrode, a reference electrode and a ground electrode.
  • the neuromodulation system as described above, which further includes a terminal in which an application program APP is installed; the APP performs wireless communication with the first control module; after the terminal receives the first brain electrical signal , Displaying the first brain electrical signal on the APP; the terminal sends the first instruction and the second instruction to the first control module.
  • a terminal in which an application program APP is installed; the APP performs wireless communication with the first control module; after the terminal receives the first brain electrical signal , Displaying the first brain electrical signal on the APP; the terminal sends the first instruction and the second instruction to the first control module.
  • a second aspect of the present application provides a wearable neuromodulation device, including a wearable stent and the neuromodulation system according to any one of the first aspect of the present application; the neuromodulation system is arranged on the wearable stent.
  • the neuromodulation system includes a first acquisition module, a first stimulation module, and a second stimulation module that are electrically connected to a first control module; the first control module receives the acquisition instruction, and sends the acquisition instruction to the first acquisition module; After an acquisition module receives the acquisition instruction, the first acquisition module acquires the first EEG signal; when the first EEG signal is diagnosed as abnormal, the first control module receives the first instruction and the second instruction; the first control The module sends the first instruction to the first stimulation module. After receiving the first instruction, the first stimulation module releases the first electrical stimulation to the first brain area; the first control module sends the second instruction to the second stimulation module. After receiving the second instruction, the second stimulation module releases the second electrical stimulation to the second brain area.
  • This application uses two stimulation modules to directly release electrical stimulation to the scalp, with minimal side effects, but the treatment effect is relatively obvious, and multiple stimulation modules are provided to simultaneously treat multiple brain regions with relatively high efficiency.
  • Figure 1 is a structural block diagram of the first neuromodulation system provided by the first embodiment of the present invention.
  • Fig. 2 is a structural block diagram of a second neuromodulation system provided by the first embodiment of the present invention
  • FIG. 4 is a structural block diagram of a fourth neuromodulation system provided by the first embodiment of the present invention.
  • Fig. 5 is a circuit diagram of a data acquisition unit of a neuromodulation system provided by an embodiment of the present invention.
  • Fig. 6 is a circuit diagram of a first control module of a neuromodulation system provided by an embodiment of the present invention.
  • Fig. 7 is a circuit diagram of a digital isolation unit of a neuromodulation system provided by an embodiment of the present invention.
  • Fig. 8 is a circuit diagram of a power isolation unit of a neuromodulation system provided by an embodiment of the present invention.
  • Fig. 9 is a structural block diagram of a neuroregulation system provided by a second embodiment of the present invention.
  • Fig. 10 is a structural block diagram of a neuroregulation system provided by a third embodiment of the present invention.
  • Fig. 11 is a schematic structural diagram of a fourth embodiment of the present invention.
  • the first neuromodulation system provided by the first embodiment of the present invention includes a first acquisition module 100, a first stimulation module 200, a first control module 300, and a second stimulation module 400; the first acquisition module 100. Both the first stimulation module 200 and the second stimulation module 400 are electrically connected to the first control module 300.
  • the first control module 300 receives the acquisition instruction, and transmits the acquisition instruction to the first acquisition module 100. After the first acquisition module 100 receives the acquisition instruction, the first acquisition module 100 acquires the first EEG signal; When the diagnosis is abnormal, the first control module 300 receives the first instruction and the second instruction; the first control module 300 sends the first instruction to the first stimulation module 200, and after the first stimulation module 200 receives the first instruction, Release the first electrical stimulation to the first brain area; the first control module 300 sends the second instruction to the second stimulation module 400, and after receiving the second instruction, the second stimulation module 400 releases the second electrical stimulation to the second brain area .
  • the above-mentioned first acquisition module 100 is made of a TGAT generation EEG acquisition chip, and the specific circuit diagram is shown in FIG. 5; the first control module 300 is made of an STM8 chip, and the specific circuit diagram is shown in FIG.
  • the first collection module 100 when in use, the first collection module 100 first collects the first EEG signal, and doctors and other professionals with professional knowledge judge the patient’s brain neural network level based on the first EEG signal. In the case of activity, if the doctor confirms that the electrical activity of the brain neural network of the patient is disordered, that is, it is judged that the first brain electrical signal is abnormal, the patient needs to be stimulated. Specifically, the treatment plan is to use the first stimulation module 200 to release the first electrical stimulation to the first brain area, and use the second stimulation module 400 to release the second electrical stimulation to the second brain area.
  • first brain area and the second brain area respectively correspond to different areas of the brain scalp.
  • the first brain area may be, for example, the hindbrain area, and the second brain area may be, for example, the parietal area; or the first brain area may be The forehead area, the second brain area can be the temple area and so on.
  • Both the first electrical stimulation and the second electrical stimulation may be direct current stimulation, alternating current stimulation, sine wave stimulation, square wave stimulation, random noise stimulation, and the like.
  • the maximum amplitude of the first electrical stimulation and the second electrical stimulation is 1.6 mA; the frequency of the sine wave stimulation and the square wave stimulation is 0 to 1000 Hz, and the adjustment accuracy is 1 Hz.
  • the parameters of the first electrical stimulation and the second electrical stimulation include current intensity, stimulation time, and stimulation frequency.
  • the first stimulation module 200 and the second stimulation module 400 described above are independent of each other. Therefore, the parameters of the first electrical stimulation and the second electrical stimulation released by each may be the same or different.
  • the first instruction and the second instruction received by the first control module 300 are issued by a terminal, and the terminal includes a first acquiring unit, a first sending unit, and a second sending unit; the first acquiring unit acquires The first EEG signal; the first sending unit sends the first instruction; the second sending unit sends the second instruction.
  • the terminal can be a computer, mobile phone, or IPAD, etc., and there is no restriction here.
  • the terminal can be used in any neuromodulation system in any embodiment of the present invention to send instructions and obtain collected brain electrical signals from it.
  • a corresponding application application, APP
  • the APP can be used on systems such as Windows, Andriod, or IOS.
  • the first collection module collects the first EEG signal. After the first collection module receives the collection instruction, it starts to collect the first EEG signal; The unit acquires the first EEG signal, that is, the first acquisition module sends the collected first EEG signal to the first control module 300, the first control module 300 receives the first EEG signal, and then the first acquisition unit receives the first EEG signal from The first control module 300 obtains the first brain electrical signal.
  • the terminal After the terminal obtains the first EEG signal, it displays the detailed information of the first EEG signal on the APP; at this time, doctors and other professionals view the first EEG signal and judge whether the first EEG signal is abnormal. If the first EEG signal is abnormal, professionals such as doctors can operate the APP, so that the first sending unit on the APP sends the first instruction to the first control module 300, and the second sending unit on the APP sends the second instruction.
  • an instruction can be sent on the APP to make the first stimulation module 200 and the second stimulation module 400 start working at the same time.
  • instructions can also be sent on the APP to make the first stimulation module 200 and the second stimulation module 400 work independently, and the user can select the first stimulation module 200 or the second stimulation module 400 to work according to actual needs.
  • the first button, the second button, and the third button can be set on the APP.
  • the first collection module 100 starts to collect the first EEG signal according to the instructions of the terminal, that is, the first collection module 100 is electrically connected to the first control module 300, and the terminal sends collection instructions for the first collection module 100
  • the first control module 300 receives the collection instruction for the first collection module 100, and controls the first collection module 100 to start collecting the first brain electrical signal.
  • the first control module 300 can obtain the collected first EEG signal, and send the first EEG signal to the terminal for display. That is, the fourth button can be set on the APP, and the fourth button is pressed, the first collection module 100 starts to work, and the fourth button is pressed again, the first collection module 100 stops working.
  • Both the first stimulation module 200 and the second stimulation module 400 include stimulation electrodes 420 and stimulation.
  • the circuit 410, the stimulation electrode 420, and the stimulation circuit 410 are electrically connected; the stimulation circuit 410 of the first stimulation module 200 is electrically connected to the first control module 300, and the stimulation circuit 410 of the second stimulation module 400 is electrically connected to the second control module 500 to stimulate
  • the circuit 410 is used to output a constant current to the stimulation electrode 420, and the stimulation electrode 420 is used to release direct current stimulation.
  • the stimulation circuit 410 includes a boost circuit and a constant current source circuit.
  • the boost circuit is mainly used to convert the 3.3V power supply into the 12V power source required by the constant current source circuit.
  • the constant current source circuit can output a constant current, which is transmitted to the stimulator.
  • the stimulation electrode 420 releases the first electrical stimulation to the first brain area or releases the second electrical stimulation to the second brain area.
  • those skilled in the art can implement this in other ways.
  • the above-mentioned first acquisition module 100 includes an EEG acquisition electrode 120 and a data acquisition unit 110.
  • the data acquisition unit 110 is electrically connected to the first control module 300.
  • the EEG acquisition electrode 120 is electrically connected to the data acquisition unit 110, the EEG acquisition electrode 120 is used to collect the first EEG signal, and then the EEG acquisition unit 120 sends the first EEG signal to the data acquisition unit 110; the data acquisition unit After receiving the first EEG signal, 110 converts the first EEG signal into a digital signal and sends it to the first control module 300.
  • the EEG collection electrode 120 can be made of one of silver, silver chloride, stainless steel, or gold.
  • the EEG stimulation electrodes 120 include three types of EEG electrodes, reference electrodes, and ground electrodes.
  • the electrodes 120 are brain electrical electrodes, reference electrodes, and ground electrodes, respectively. It can be seen from the above that the nerve regulation system provided by the first embodiment of the present invention can directly release electrical stimulation to the scalp, with minimal side effects and relatively obvious therapeutic effects.
  • two stimulation modules two brain regions can be treated at the same time, and the currents of the two channels do not interfere with each other, and the treatment efficiency is also high.
  • the neuromodulation system in the first embodiment may further include a second control module 500 and a digital isolation unit 610.
  • the second control module 500 is connected between the first control module 300 and the second stimulation module 400, and the digital The isolation unit 610 is connected between the first control module 300 and the second control module 500; the first control module 300 sends the second instruction to the digital isolation unit 610; after receiving the second instruction, the digital isolation unit 610 responds to the second instruction Perform galvanic interference isolation processing, and send the second instruction after isolation processing to the second control module 500; after receiving the second instruction after isolation processing, the second control module 500 sends the second instruction after isolation processing to the second stimulus Module 400: When the second stimulation module 400 receives the second instruction, it starts to release the second electrical stimulation to the second brain area.
  • the digital isolation unit 610 isolates the current interference between the first stimulation module 200 and the second stimulation module 400.
  • the digital isolation unit 610 also ensures that the first control module 300 and the second control module 500 communicate normally.
  • the digital isolation unit 610 is provided with an IC interface, which can ensure that the first control module 300 and the second control module 500 Normal communication.
  • the implementation circuit diagram of the digital isolation unit 610 is shown in FIG. 7.
  • Setting the second control module 500 to control the second stimulation module 400, and connect the digital isolation unit 610 between the first control module 300 and the second control module 500, can reduce the interference between the first stimulation module 200 and the second stimulation module 400 Current interference, so that the two stimulation modules can each better release electrical stimulation to ensure the treatment effect and safety.
  • the neuromodulation system provided in the first embodiment can also add a wireless module 700, which is electrically connected to the first control module 300, and the wireless module 700 is used to, after receiving the first instruction and the second instruction, The received first instruction and second instruction are transmitted to the first control module 300.
  • the wireless module 700 may be a low-power WIFI transmission module, and specifically, a USR-C210 wifi module may be used. That is, the wireless module 700 actually plays a role in facilitating communication between the first control module 300 and an external device (for example, a terminal).
  • the wireless module 700 can transmit the collected first brain electrical signal to an external device, and can also transmit the signal of the external device to the first control module 300.
  • the first embodiment may further include a power supply module 800, the power supply module 800 includes a main power supply unit 810, the main power supply unit 810 is used to supply power to the first acquisition module 100, the first stimulation module 200, and the first control module 300 .
  • the neuromodulation system provided in the first embodiment may also include an auxiliary power supply unit 820 and a power isolation unit 620.
  • the auxiliary power supply unit 820 is electrically connected to the main power supply unit 810, and the main power supply unit 810 is also used to The power supply unit 820 supplies power, and the auxiliary power supply unit 820 is used to supply power to the second stimulation module 400 and the second control module 500.
  • the main power supply unit 810 transmits the electrical energy to the power isolation unit 620; after receiving the electrical energy, the power isolation unit 620 performs galvanic interference isolation processing on the electrical energy, and transmits the isolated electrical energy to the auxiliary power supply unit 820 yuan ; After the auxiliary power supply unit 820 receives the isolated electrical energy, it transmits the isolated electrical energy to the second control module 500; after the second control module 500 receives the isolated electrical energy, it transfers the isolated electrical energy The electric energy is transmitted to the second stimulation module 400.
  • a power isolation unit 620 is provided.
  • the power isolation unit 620 is connected between the main power supply unit 810 and the auxiliary power supply unit 820 and is used to isolate current interference between the first stimulation module 200 and the second stimulation module 400.
  • the implementation circuit diagram of the power isolation unit 620 is shown in FIG. 8.
  • the digital isolation unit 610 and the power isolation unit 620 can form an isolation module 600, which is arranged between the first stimulation module 200 and the second stimulation module 400; the main power supply unit 810 and the auxiliary power supply unit 820 constitute the power supply module 800.
  • the first stimulation module 200 has a separate first control module 300 and a main power supply unit 810
  • the second stimulation module 400 has a separate second control module 500 and an auxiliary power supply unit 820, so the first stimulation module 200 and the second stimulation module
  • the current crosstalk between the modules 400 is completely isolated, which can ensure that the first stimulation module 200 and the second stimulation module 400 independently release electrical stimulation, and increase the accuracy and safety performance of the first electrical stimulation and the second electrical stimulation treatment.
  • the second embodiment is based on any neuromodulation system of the first embodiment, adding a third stimulation module 400a, and the third stimulation module 400a is electrically connected to the first control module 300; in the first brain When the electrical signal is diagnosed as abnormal, the first control module 300 receives the third instruction, and then the first control module 300 sends the first instruction to the third stimulation module 400a; after the third stimulation module 400a to the third instruction, The third brain area releases the third electrical stimulation.
  • the first acquisition module 100 When in use, the first acquisition module 100 first collects the first EEG signal. The doctor and other professionals with professional knowledge can judge the electrical activity of the patient’s brain neural network based on the first EEG signal. If the doctor confirms the patient’s brain neural network Disturbance of electrical activity, that is, abnormality of the first brain electrical signal. At this time, the patient needs to be treated with stimulation. Specifically, the treatment plan is to cause the first stimulation module 200 to release the first electrical stimulation to the first brain area, and the second stimulation module 400 to release the second electrical stimulation to the second brain area, so that The third stimulation module 400a releases the third electrical stimulation to the third brain area.
  • the first brain area, the second brain area, and the third brain area correspond to different areas of the scalp.
  • the three brain areas correspond to the forehead area, the hindbrain area, and the temple area, or each target three other areas. It needs to be emphasized However, the three brain regions are all different areas on the scalp of the brain.
  • the third electrical stimulation may be direct current stimulation, alternating current stimulation, sine wave stimulation, square wave stimulation, random noise stimulation, etc.
  • the parameters of the third electrical stimulation include current intensity, stimulation time, and stimulation frequency.
  • the first stimulation module 200, the second stimulation module 400, and the third stimulation module 400a are all independent of each other. Therefore, the parameters of the first electrical stimulation, the second electrical stimulation, and the third electrical stimulation released by each of them may be the same or not. the same.
  • a third stimulation module 400a is added, which can simultaneously perform electrical stimulation on three different brain regions, which further enhances the therapeutic effect and efficiency.
  • a third control module 500a may be provided for the third stimulation module 400a.
  • the third control module 500a is connected between the first control module 300 and the third control module 500a.
  • the first control module 300 receives the third control module 500a.
  • the three instructions are sent to the third control module 500a, and the third control module 500a receives the third instruction to release the third electrical stimulation to the third brain area.
  • a digital isolation unit 610 may be provided between the first control module 300 and the third control module 500a, so as to isolate the current interference between the first stimulation module 200 and the third stimulation module 400a.
  • An auxiliary power supply unit 820 may also be provided for the third stimulation module 400a, and the auxiliary power supply unit 820 supplies power to the third stimulation module 400a and the third control module 500a.
  • a power isolation unit 620 can be provided between the main power supply unit 810 and the auxiliary power supply unit 820 for the third stimulation module 400a to further isolate the current between the first stimulation module 200 and the third stimulation module 400a. interference.
  • a fourth stimulation module a fifth setting module... etc. can also be provided, and the setting method is the same as that of the third stimulation module 400a, which will not be detailed here.
  • the terminal may further include a third sending unit, and the third sending unit sends the third instruction.
  • the third instruction is directed to the neuroregulation system provided with the third stimulation module 400a.
  • the specific scheme is the same as that of the first sending unit and the second sending unit.
  • a fifth button can be set on the APP to control the sending of the third instruction, etc., which will not be repeated.
  • the third embodiment is based on any neuromodulation system of the first embodiment, adding a second acquisition module 110a, and the second acquisition module 110a acquires the second EEG signal; in the first EEG signal And the second EEG signal is diagnosed as abnormal, the first control module 300 receives the first instruction and the second instruction; the first control module 300 sends the first instruction to the first stimulation module 200, the first stimulation module 200 After receiving the first instruction, release the first electrical stimulation to the first brain area; the first control module 300 sends the second instruction to the second stimulation module 400, and the second stimulation module 400 sends the second instruction to the second stimulation module 400 after receiving the second instruction.
  • the brain area releases a second electrical stimulus. That is, professionals such as doctors determine the first instruction and the second instruction according to the comprehensive abnormality of the first EEG signal and the second EEG signal, and then operate the APP so that the first instruction and the second instruction are issued to the first control Module 300.
  • the first control module 300 receives the first instruction; in the case where the second EEG signal is diagnosed as abnormal, the first control module 300 receives the second instruction; The first control module 300 sends the first instruction to the first stimulation module 200. After receiving the first instruction, the first stimulation module 200 releases the first electrical stimulation to the first brain area; the first control module 300 sends the second instruction To the second stimulation module 400, after receiving the second instruction, the second stimulation module 400 releases the second electrical stimulation to the second brain area. That is, professionals such as doctors determine to release the first electrical stimulus to the first brain area based on the abnormality of the first brain electrical signal, and determine to release the second electrical stimulus to the second brain area based on the abnormality of the second brain electrical signal.
  • the first EEG signal and the first electrical stimulation are preferably directed to the same brain scalp area.
  • the collected first EEG signal is a signal in the back brain area
  • the first brain electrical signal is released for the back brain area.
  • Electrical stimulation Likewise, the second brain electrical signal and the second electrical stimulation are preferably directed to the same brain scalp area.
  • the first collection module 100 and the second collection module 110a collect EEG signals from different regions on the scalp of the brain.
  • the doctor can determine the parameters of the first stimulation module 200 and the second stimulation module 400 according to the comprehensive judgment result of the first brain electrical signal and the second brain electrical signal, and they can also be set to be different or the same.
  • the doctor can also determine the parameters of the first stimulation module 200 according to the condition of the first brain electrical signal, and determine the parameters of the second stimulation module 400 according to the condition of the second brain electrical signal.
  • the first collection module 100 can collect the first EEG signal of the first brain area
  • the second collection module 110a can collect the second EEG signal of the second brain area
  • the doctor determines the first EEG signal according to the first EEG signal.
  • the parameters of the first electrical stimulation applied to the first brain area by the stimulation module 200 are determined according to the second brain electrical signal, so as to achieve targeted The release of electrical stimulation increases the accuracy of diagnosis and treatment.
  • a third collection module and a fourth collection module can also be set, etc., which will not be described again.
  • the terminal may also include a second acquisition unit, and the second acquisition unit acquires the second EEG signal; when the doctor diagnoses that the first EEG signal and the second EEG signal are abnormal, the doctor operates the first button (that is, the first send Unit) to send the first instruction; operate the second button (that is, the second sending unit) to send the second instruction.
  • the first button that is, the first send Unit
  • the second button that is, the second sending unit
  • the doctor diagnoses that the first brain point signal is abnormal, he operates the first button (that is, the first sending unit) to send the first instruction; when the doctor diagnoses the second brain point signal is abnormal, he operates the second button (that is, the second sending unit) Send the second command.
  • the above-mentioned second acquisition unit is for the neuromodulation system provided with the second acquisition module 110a, and the specific solution is the same as that of the first acquisition unit.
  • a sixth button may be provided on the APP to control the acquisition of the second brain electrical signal.
  • a fifth embodiment of the present invention provides a wearable nerve regulation device 900, including a wearable stent and any one of the first to third embodiments of the neuromodulation system; the neuromodulation system is set in the Wear the brace.
  • the wearable bracket includes an annular headband 910, a connecting belt 920, and an extension belt 930; both ends of the connecting belt 920 are fixedly connected to one side of the annular headband 910, and the extension belt 930 is connected to the annular headband 910.
  • the other side is fixedly connected;
  • the first acquisition module 100 includes electrically connected brain electricity acquisition electrodes 120 and a data acquisition unit 110, the first stimulation module 200 and the second stimulation module 400 both include electrically connected stimulation circuits 410 and stimulation electrodes 420;
  • the data acquisition unit 110, the stimulation circuit 410, and the first control module 300 are all integrated on the inner side of the ring-shaped headband 910;
  • the EEG acquisition electrode 120 is arranged on the inner side of the ring-shaped headband 910 or the inner side of the extension belt 930;
  • the stimulation electrode 420 is arranged On the inner side of the annular headband 910 or the inner side of the connecting belt 920.
  • the brain electrical stimulation electrodes 120 include three types of brain electrical stimulation electrodes, reference electrodes, and ground electrodes.
  • the three brain electrical stimulation electrodes 120 are brain electrical electrodes, reference electrodes, and ground electrodes, respectively.
  • the following is a specific embodiment in which the number of stimulation electrodes 420 of the first stimulation module 200 and the second stimulation module 400 are both two, and the two stimulation electrodes 420 of the first stimulation module 200 are respectively provided at both ends of the inner side of the connecting belt 920 ;
  • the two stimulation electrodes 420 of the second stimulation module 400 are both arranged on the inner side of the ring-shaped headband 910.
  • the stimulating electrode 420 can be made of silver or silver chloride.
  • the stimulating electrode 420 can directly contact the scalp, and there is no need to apply conductive glue during use.
  • the data acquisition unit 110, the stimulation circuit 410, and the first control module 300 are integrated on a circuit board 940 installed on the inner side of the ring-shaped headband 910, corresponding to the area of the back of the patient's head.
  • the neuromodulation system including the second control module 500, the third control module 500a, the wireless module 700, the power supply module, and the isolation module 600, except for the stimulation electrode 420 in the stimulation module and the EEG acquisition in the acquisition module Except for the electrode 120, the rest of the components are all integrated on a circuit board 940.
  • the structure compactness of the wearable nerve control device 900 is increased, which is convenient for the patient to wear.

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Abstract

一种神经调控系统，包括第一采集模块（100）、第一刺激模块（200）、第一控制模块（300）和第二刺激模块（400）；第一采集模块（100）、第一刺激模块（200）和第二刺激模块（400）与第一控制模块（300）电连接；第一控制模块（300）接收采集指令然后发送至第一采集模块（100）；第一采集模块（100）接收到采集指令后采集第一脑电信号；第一脑电信号被诊断为异常后，第一控制模块（300）接收第一指令然后发送至第一刺激模块（200），第一刺激模块（200）接收到第一指令后，向第一脑区释放第一电刺激；第一控制模块（300）接收第二指令然后发送至第二刺激模块（400），第二刺激模块（400）接收到第二指令后，向第二脑区释放第二电刺激。该系统副作用极小，治疗效果明显，设置多个刺激模块，可以同时对多个脑区进行治疗，效率比较高。

Description

一种神经调控系统及可穿戴神经调控装置 技术领域
本申请涉及医疗用电路器件技术领域，尤其涉及一种神经调控系统及可穿戴神经调控装置。
 背景技术
大脑是一个由成千亿个神经元组成的器官，这些神经元形成一个相互交织的神经网络，神经网络之间通过神经元的膜电位发放进行信息的传递与整合，因此，神经环路的异常也可以认为是大脑神经网络电活动的紊乱。为了对电活动紊乱的神经环路进行调控，科学家们研发出了神经调控技术，即利用一种有创或者无创的手段，调控大脑的电活动，从而实现调节大脑状态的目的。
目前，可以用于神经环路调控的技术包括自然刺激、药物干预、电、磁、力刺激等，本质上都是改变神经网络的电活动。在这之中，自然刺激最容易使患者接受，极少副作用，但效果甚微；药物干预使用最为广泛，但其影响神经环路的方式是间接的，并伴随副作用较大。电、磁、力刺激作用较为直接，尤其是通过外部非侵入式的施加刺激干预，能够减轻患者的痛苦。目前，无创经颅电刺激（transcranial Electrical Stimulation, tES）因其无创性、方便性而广泛运用于神经调控领域中，成为认知神经科学、脑科学研究，精神疾病治疗的主要手段之一，并且结合神经影像学技术，如磁共振成像、脑电图、脑磁图等技术，可以实现更加精准、高效的调控。
然而，在实际应用电、磁和力刺激时，目前的治疗系统的疗效不明显，效率较为低下，因此急需一种治疗效果明显，效率较高的治疗系统。
 技术问题
本申请的目的在于提供一种神经调控系统，以解决上述问题，本申请利用两个刺激模块直接对头皮释放电刺激，副作用极小，但是治疗效果较为明显，并且设置多个刺激模块，可以同时对多个脑区进行治疗，效率比较高。
 技术解决方案
本申请第一方面提供一种神经调控系统，包括所述第一采集模块、第一刺激模块和第二刺激模块与所述第一控制模块电连接；所述第一控制模块接收采集指令，将所述采集指令发送至所述第一采集模块；所述第一采集模块接收到所述采集指令后，所述第一采集模块采集第一脑电信号；在所述第一脑电信号被诊断为异常的情况下，所述第一控制模块接收第一指令和第二指令；所述第一控制模块将所述第一指令发送至所述第一刺激模块，所述第一刺激模块接收到所述第一指令后，向第一脑区释放第一电刺激；所述第一控制模块将所述第二指令发送至所述第二刺激模块，所述第二刺激模块接收到所述第二指令后，向第二脑区释放第二电刺激。
如上所述的神经调控系统，其中，还包括第二控制模块和数字隔离单元，所述第二控制模块连接在所述第一控制模块和所述第二刺激模块之间；所述数字隔离单元连接在所述第一控制模块和所述第二控制模块之间；
所述第一控制模块将所述第二指令发送至所述数字隔离单元；所述数字隔离单元接收到所述第二指令后，对所述第二指令进行电流干扰隔离处理，将隔离处理后的所述第二指令发送至所述第二控制模块；所述第二控制模块接收隔离处理后的所述第二指令后，将隔离处理后的所述第二指令发送至所述第二刺激模块。
如上所述的神经调控系统，其中，还包括无线模块，所述无线模块与所述第一控制模块电连接；所述无线模块用于在接收到所述第一指令和所述第二指令后，将所述第一指令和所述第二指令传输至所述第一控制模块。
如上所述的神经调控系统，其中，还包括主供电单元；所述主供电单元用于向所述第一采集模块、第一刺激模块和第一控制模块供电。
如上所述的神经调控系统，其中，还包括辅供电单元和电源隔离单元；所述辅供电单元与所述第二控制模块电连接；所述电源隔离单元连接在所述主供电单元和所述辅供电单元之间；
所述主供电单元用于向所述辅供电单元提供电能源，所述辅供电单元用于向第二控制模块和第二刺激模块提供电能源；所述主供电单元将电能源传输至所述电源隔离单元；所述电源隔离单元接收到所述电能源后，对所述电能源进行电流干扰隔离处理，将隔离处理后的所述电能源传输至所述辅供电单元；所述辅供电单元接收到隔离处理后的所述电能源后，将隔离处理后的所述电能源传输至所述第二控制模块；所述第二控制模块接收到隔离处理后的所述电能源后，将隔离处理后的所述电能源传输至所述第二刺激模块。
如上所述的神经调控系统，其中，还包括第三刺激模块，所述第三刺激模块和所述第一控制模块电连接；在所述第一脑电信号被诊断为异常的情况下，所述第一控制模块接收第三指令；所述第一控制模块将所述第三指令发送至所述第三刺激模块，所述第三刺激模块接收到所述第三指令后，向第三脑区释放第三电刺激。
如上所述的神经调控系统，其中，还包括第二采集模块，所述第二采集模块采集第二脑电信号；在所述第一脑电信号和第二脑电信号被诊断为异常的情况下，所述第一控制模块接收所述第一指令和第二指令；所述第一控制模块将所述第一指令发送至所述第一刺激模块，所述第一刺激模块接收到所述第一指令后，向第一脑区释放第一电刺激；所述第一控制模块将所述第二指令发送至所述第二刺激模块，所述第二刺激模块接收到所述第二指令后，向第二脑区释放第二电刺激；或者，在所述第一脑电信号被诊断为异常的情况下，所述第一控制模块接收所述第一指令；在所述第二脑电信号被诊断为异常的情况下，所述第一控制模块接收所述第二指令；所述第一控制模块将所述第一指令发送至所述第一刺激模块，所述第一刺激模块接收到所述第一指令后，向第一脑区释放第一电刺激；所述第一控制模块将所述第二指令发送至所述第二刺激模块，所述第二刺激模块接收到所述第二指令后，向第二脑区释放第二电刺激。
如上所述的神经调控系统，其中，所述第一电刺激和第二电刺激为直流刺激、正弦波刺激、方波刺激或者随机噪声刺激中任意一种；所述第一电刺激和第二电刺激的最大幅度为1.6mA；所述正弦波刺激和方波刺激的频率为0至1000Hz，且调节精度为1Hz。
如上所述的神经调控系统，其中，所述第一采集模块包括脑电采集电极和数据采集单元；所述数据采集单元和所述第一控制模块电连接，所述脑电采集电极和所述数据采集单元电连接；所述脑电采集电极用于采集第一脑电信号，用于采集第一脑电信号，将第一脑电信号发送至所述数据采集单元；所述数据采集单元接收到第一脑电信号后，将第一脑电信号转换为数字信号并发送至所述第一控制模块。
如上所述的神经调控系统，其中，所述脑电采集电极包括脑电电极、参考电极和地电极。
如上所述的神经调控系统，其中，还包括终端，所述终端中安装有应用程序APP；所述APP与所述第一控制模块进行无线通讯；所述终端接收所述第一脑电信号后，将第一脑电信号显示在所述APP上；所述终端向所述第一控制模块发送所述第一指令和第二指令。
本申请第二方面提供一种可穿戴神经调控装置，包括可穿戴支架和本申请中第一方面任一项所述的神经调节系统；所述神经调节系统设置在所述可穿戴支架上。
如上所述的可穿戴神经调控装置，其中，所述可穿戴支架包括环形头箍带、连接带和延伸带；所述连接带的两端均与所述环形头箍带的一侧固定连接，所述延伸带与所述环形头箍带的另一侧固定连接；所述第一采集模块包括电连接的脑电采集电极和数据采集单元，所述第一刺激模块和所述第二刺激模块均包括电连接的刺激电路和刺激电极；所述数据采集单元、刺激电路和第一控制模块均集成在所述环形头箍带的内侧；所述脑电采集电极设置在所述环形头箍带的内侧或者所述延伸带的内侧；所述刺激电极设置在所述环形头箍带的内侧或者所述连接带的内侧。
 有益效果
本申请提供的神经调控系统，包括第一采集模块、第一刺激模块和第二刺激模块与第一控制模块电连接；第一控制模块接收采集指令，将采集指令发送至第一采集模块；第一采集模块接收到采集指令后，第一采集模块采集第一脑电信号；在第一脑电信号被诊断为异常的情况下，第一控制模块接收第一指令和第二指令；第一控制模块将第一指令发送至第一刺激模块，第一刺激模块接收到第一指令后，向第一脑区释放第一电刺激；第一控制模块将第二指令发送至第二刺激模块，第二刺激模块接收到第二指令后，向第二脑区释放第二电刺激。本申请利用两个刺激模块直接对头皮释放电刺激，副作用极小，但是治疗效果较为明显，并且设置多个刺激模块，可以同时对多个脑区进行治疗，效率比较高。
 附图说明
为了更清楚地说明本发明的技术方案，下面将对实施方式中所需要使用的附图作简单地介绍，显而易见地，下面描述中的附图仅仅是本发明的一些实施方式，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以如这些附图获得其他的附图。
图1是本发明第一实施例提供的第一种神经调控系统的结构框图；
图2是本发明第一实施例提供的第二种神经调控系统的结构框图；
图3是本发明第一实施例提供的第三种神经调控系统的结构框图；
图4是本发明第一实施例提供的第四种神经调控系统的结构框图；
图5是本发明实施例提供的神经调控系统的数据采集单元的电路图；
图6是本发明实施例提供的神经调控系统的第一控制模块的电路图；
图7是本发明实施例提供的神经调控系统的数字隔离单元的电路图；
图8是本发明实施例提供的神经调控系统的电源隔离单元的电路图；
图9是本发明第二实施例提供的神经调控系统的结构框图；
图10是本发明第三实施例提供的神经调控系统的结构框图；
图11是本发明第四实施例的结构示意图。
附图标记说明：
100-第一采集模块，110-数据采集单元，120-脑电采集电极，100a-第二采集模块， 200-第一刺激模块，300-第一控制模块，400-第二刺激模块，410-刺激电路，420-刺激电极，400a-第三刺激模块，500-第二控制模块，500a-第三控制模块，600-隔离模块，610-数字隔离单元，620-电源隔离单元，700-无线模块，800-供电模块，810-主供电单元，820-辅供电单元，900-可穿戴神经调控装置，910-环形头箍带，920-连接带，930-延伸带，940-电路板。
 本发明的实施方式
下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有作出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
第一实施例
如图1所示，本发明第一实施例提供的第一种神经调控系统，包括第一采集模块100、第一刺激模块200、第一控制模块300和第二刺激模块400；第一采集模块100、第一刺激模块200和第二刺激模块400均与第一控制模块300电连接。
第一控制模块300接收采集指令，将采集指令传输至第一采集模块100，第一采集模块100接收到采集指令后，第一采集模块100采集第一脑电信号；在第一脑电信号被诊断为异常的情况下，第一控制模块300接收第一指令和第二指令；第一控制模块300将第一指令发送至第一刺激模块200，第一刺激模块200接收到第一指令后，向第一脑区释放第一电刺激；第一控制模块300将第二指令发送至第二刺激模块400，第二刺激模块400接收到第二指令后，向第二脑区释放第二电刺激。
上述第一采集模块100采用TGAT一代脑电采集芯片制成，具体电路图如图5所示；第一控制模块300采用STM8芯片制成，具体电路图如图6所示。
本发明第一实施例中的神经调控系统，在使用时，第一采集模块100首先采集第一脑电信号，医生等具有专业知识的人员根据该第一脑电信号判断患者的大脑神经网络电活动的情况，如果医生确认该患者大脑神经网络电活动紊乱，也即判断该第一脑电信号异常，此时需要对患者进行刺激治疗。具体地，治疗方案为使用第一刺激模块200向第一脑区释放第一电刺激，使用第二刺激模块400向第二脑区释放第二电刺激。由上可见，本发明第一实施例提供的神经调控系统，可以直接对头皮释放电刺激，副作用极小，治疗效果较为明显。并且设置有了两个刺激模块，可以同时对两个脑区进行治疗，治疗效率也较高。
应当理解的是，该第一脑区和第二脑区分别对应大脑头皮的不同区域，第一脑区例如可以为后脑区域，第二脑区例如可以为头顶区域；或者是第一脑区为前额区域，第二脑区可以为太阳穴区域等。
第一电刺激和第二电刺激均可以为直流刺激、交流刺激、正弦波刺激、方波刺激、随机噪声刺激等。所述第一电刺激和第二电刺激的最大幅度为1.6mA；所述正弦波刺激和方波刺激的频率为0至1000Hz，且调节精度为1Hz。第一电刺激和第二电刺激的参数包括电流强度、刺激时间和刺激频率等。上述第一刺激模块200和第二刺激模块400相互独立，因此，各自释放的第一电刺激和第二电刺激的参数可以相同，也可以不相同。
本领域技术人员可以理解的是，第一控制模块300接收的第一指令和第二指令由终端发出，该终端包括第一获取单元、第一发送单元和第二发送单元；第一获取单元获取第一脑电信号；第一发送单元发送第一指令；第二发送单元发送第二指令。该终端可以是电脑、手机或者IPAD等设备，在此不做限制。
该终端可以用于本发明任意实施例中任意一种神经调控系统发送指令，以及从其中获取采集的脑电信号。具体地，终端上安装有对应的应用程序（application，APP），该APP可以在Windows、Andriod或者IOS等系统上使用。
详细工作流程如下：
医生等专业人士操作APP，使得APP向第一采集模块发送采集指令，第一采集模块采集第一脑电信号，第一采集模块接收到采集指令后，开始采集第一脑电信号；第一获取单元获取该第一脑电信号，也即第一采集模块将采集的第一脑电信号发送至第一控制模块300，第一控制模块300接收该第一脑电信号，然后第一获取单元从第一控制模块300获取该第一脑电信号。
终端获取到第一脑电信号之后，在APP上显示第一脑电信号的详细信息；此时医生等专业人士查看该第一脑电信号，并判断该第一脑电信号是否异常，如果判断该第一脑电信号异常，则医生等专业人士可以操作APP，使得APP上的第一发送单元向第一控制模块300发送第一指令，使得APP上的第二发送单元发送第二指令。
具体地，APP上可以发送指令，以使第一刺激模块200和第二刺激模块400同时开始工作。在另一实施例中，APP上也可以发送指令，以使第一刺激模块200和第二刺激模块400独立工作，用户可以根据实际需求，选择第一刺激模块200或者第二刺激模块400工作。具体实现时，可以在APP上设置第一按钮、第二按钮和第三按钮，其中按下第一按钮，可以控制第一刺激模块200工作，再次按下按钮，第一刺激模块200停止工作；按下第二按钮可以控制第二刺激模块400工作，再次按下第二按钮，第二刺激模块400停止工作；按下第三按钮可以控制第一刺激模块200和第二刺激模块400同时工作（此时，第一指令和第二指令为同一指令），再次按下第三按钮，第一刺激模块200和第二刺激模块400同时停止工作。
可以理解的是，第一采集模块100根据终端的指令开始采集第一脑电信号，也即第一采集模块100与第一控制模块300电连接，终端发送针对第一采集模块100的采集指令，第一控制模块300接收针对第一采集模块100的采集指令，控制第一采集模块100开始采集第一脑电信号。第一控制模块300可以获取该采集的第一脑电信号，并将第一脑电信号发送至终端上进行显示。也即可以在APP上设置第四按钮，按下第四按钮，第一采集模块100开始工作，再次按下第四按钮，第一采集模块100停止工作。
请参考图4，以下详述产生直流刺激的一种刺激模块，可以应用于第一刺激模块200和第二刺激模块400，第一刺激模块200和第二刺激模块400均包括刺激电极420和刺激电路410，刺激电极420和刺激电路410电连接；第一刺激模块200的刺激电路410与第一控制模块300电连接，第二刺激模块400的刺激电路410与第二控制模块500电连接，刺激电路410用于向刺激电极420输出恒定电流，刺激电极420用于释放直流刺激。刺激电路410包括升压电路和恒流源电路，升压电路主要用于将3.3V电源转换成恒流源电路所需要的12V电源，恒流源电路可以输出恒定电流，该恒定电流传输至刺激电极420上，以使刺激电极420向第一脑区释放第一电刺激或者向第二脑区释放第二电刺激。当然本领域技术人员用其他方式实现。
请参考图4，以下详述一种第一采集模块100的具体实施方式，上述第一采集模块100包括脑电采集电极120和数据采集单元110，数据采集单元110与第一控制模块300电连接，脑电采集电极120与数据采集单元110电连接，脑电采集电极120用于采集第一脑电信号，然后脑电采集单元120将第一脑电信号发送至数据采集单元110；数据采集单元110接收到第一脑电信号后，将第一脑电信号转换为数字信号并发送至第一控制模块300。脑电采集电极120可以采用银、氯化银、不锈钢或者金等材料中的一种制成，脑电采集电极120能够直接接触头皮，使用时不需要上导电胶，采集到的信号为10uV量级的电信号。脑电采集电极120采集的信号为模拟电信号，经过数字采集单元的放大、模拟滤波和A/D转换之后，最终输出为数字信号，该数字信号最终可以被传输至终端上，以供医生等专业人士查看和判断。数据采集单元110可以采用TGAG一代脑电采集芯片实现，具体请参考图5。
以下列举一种第一采集模块100中的脑电采集电极120的数量为三个的具体实施方式，脑电刺激电极120包括脑电电极、参考电极和地电极三种，上述三个脑电刺激电极120分别为脑电电极、参考电极和地电极。由上可见，本发明第一实施例提供的神经调控系统，可以直接对头皮释放电刺激，副作用极小，治疗效果较为明显。并且设置有了两个刺激模块，可以同时对两个脑区进行治疗，且两个通道的电流互不干扰，治疗效率也较高。
请参考图2，第一实施例中的神经调控系统还可以包括第二控制模块500和数字隔离单元610，第二控制模块500连接在第一控制模块300和第二刺激模块400之间，数字隔离单元610连接在第一控制模块300和第二控制模块500之间；第一控制模块300将第二指令发送至数字隔离单元610；数字隔离单元610接收到第二指令后，对第二指令进行电流干扰隔离处理，将隔离处理后的第二指令发送至第二控制模块500；第二控制模块500接收隔离处理后的第二指令后，将隔离处理后的第二指令发送至第二刺激模块400；第二刺激模块400接收到该第二指令的情况下，开始向第二脑区释放第二电刺激。
由上可见，数字隔离单元610隔离了第一刺激模块200和第二刺激模块400之间的电流干扰。当然，数字隔离单元610同时保证第一控制模块300和第二控制模块500正常通信，具体地，数字隔离单元610中设置有IC接口，该接口可以保证第一控制模块300和第二控制模块500正常通信。数字隔离单元610的实现电路图如图7所示。
设置第二控制模块500控制第二刺激模块400，并在第一控制模块300和第二控制模块500之间连接数字隔离单元610，可以降低第一刺激模块200和第二刺激模块400之间的电流干扰，以使两个刺激模块各自能够更好的释放电刺激，保证治疗效果和安全性。
请参考图4，第一实施例中提供的神经调控系统还可以增加无线模块700，无线模块700与第一控制模块300电连接，无线模块700用于在接收第一指令和第二指令后，将接收到的第一指令和第二指令传输至第一控制模块300。无线模块700可以为一低功耗WIFI传输模块，具体可以采用USR-C210wifi模块。也即该无线模块700实际上起到方便第一控制模块300和外部设备（例如终端）进行通信的作用。该无线模块700可以将采集的第一脑电信号传输至外部设备，也可以将外部设备的信号传输至第一控制模块300。
请参考图3，第一实施例还可以包括供电模块800，供电模块800包括主供电单元810，主供电单元810用于向第一采集模块100、第一刺激模块200和第一控制模块300供电。
请继续参考图2，第一实施例提供的神经调控系统还可以包括和辅供电单元820和电源隔离单元620，辅供电单元820与主供电单元810电连接，主供电单元810还用于向辅供电单元820供电，辅供电单元820用于向第二刺激模块400和第二控制模块500供电。具体地，主供电单元810将电能源传输至电源隔离单元620；电源隔离单元620接收到电能源后，对电能源进行电流干扰隔离处理，将隔离处理后的电能源传输至辅供电单820元；辅供电单元820接收到隔离处理后的电能源后，将隔离处理后的电能源传输至第二控制模块500；第二控制模块500接收到隔离处理后的电能源后，将隔离处理后的电能源传输至第二刺激模块400。
同第一控制模块300和第二控制模块500之间设置数字隔离单元610同理，为了进一步的避免第一刺激模块200和第二刺激模块400之间的电流干扰，设置了电源隔离单元620，电源隔离单元620连接在主供电单元810和辅供电单元820之间，用于隔离第一刺激模块200和第二刺激模块400之间的电流干扰。电源隔离单元620的实现电路图如图8所示。
请参考图3，数字隔离单元610和电源隔离单元620可以组成隔离模块600，设置在第一刺激模块200和第二刺激模块400之间；主供电单元810和辅供电单元820组成供电模块800。至此，第一刺激模块200有单独的第一控制模块300和主供电单元810，第二刺激模块400有单独的第二控制模块500和辅供电单元820，因此第一刺激模块200和第二刺激模块400之间的电流串扰被完全隔离，可以确保第一刺激模块200和第二刺激模块400各地独立释放电刺激，增加第一电刺激和第二电刺激治疗的精准程度和安全性能。
第二实施例
请参考图9，第二实施例为在第一实施例任意一种神经调控系统的基础上，增加第三刺激模块400a，第三刺激模块400a与第一控制模块300电连接；在第一脑电信号被诊断为异常的情况下，第一控制模块300接收第三指令，然后第一控制模块300将第一指令发送至第三刺激模块400a；第三刺激模块400a到第三指令后，向第三脑区释放第三电刺激。
在使用时，第一采集模块100首先采集第一脑电信号，医生等具有专业知识的人员根据该第一脑电信号判断患者的大脑神经网络电活动的情况，如果医生确认该患者大脑神经网络电活动紊乱，也即第一脑电信号异常。此时需要对患者进行刺激治疗，具体地，治疗方案为使第一刺激模块200向第一脑区释放第一电刺激，使第二刺激模块400向第二脑区释放第二电刺激，使第三刺激模块400a向第三脑区释放第三电刺激。
该第一脑区、第二脑区和第三脑区分别对应大脑头皮的不同区域，例如三个脑区分别对应前额区域、后脑区域和太阳穴区域，或者是各自针对三个其他区域，需要强调的是，三个脑区均为大脑头皮上不同的区域。
第三电刺激可以为直流刺激、交流刺激、正弦波刺激、方波刺激、随机噪声刺激等。第三电刺激的参数包括电流强度、刺激时间和刺激频率等。上述第一刺激模块200、第二刺激模块400和第三刺激模块400a均相互独立，因此，第各自释放的第一电刺激、第二电刺激和第三电刺激的参数可以相同，也可以不相同。
该实施例中，增加了第三刺激模块400a，可以同时针对三个不同的脑区进行电刺激，更进一步地增强了治疗效果和效率。
当然，该实施例中，可以针对第三刺激模块400a设置第三控制模块500a，第三控制模块500a连接在第一控制模块300和第三控制模块500a之间，第一控制模块300接收的第三指令，发送至第三控制模块500a，第三控制模块500a接收第三指令，向第三脑区释放第三电刺激。
同理地，可以在第一控制模块300和第三控制模块500a之间设置数字隔离单元610，从而隔离第一刺激模块200和第三刺激模块400a之间的电流干扰。还可以针对第三刺激模块400a设置一个辅供电单元820，该辅供电单元820向第三刺激模块400a和第三控制模块500a供电。同样地，可以在主供电单元810和针对第三刺激模块400a的辅供电单元820之间设置一个电源隔离单元620，用以进一步的隔离第一刺激模块200和第三刺激模块400a之间的电流干扰。
本领域技术人员可以理解的是，还可以设置第四刺激模块、第五设置模块......等等，其设置方式与第三刺激模块400a相同，此处不再详述。
相应地，终端还可以包括第三发送单元，第三发送单元发送第三指令。该第三指令针对设置有第三刺激模块400a的神经调控系统。具体方案同第一发送单元和第二发送单元，例如可以在APP上设置第五按钮，用于控制第三指令的发送等，不再赘述。
第三实施例
请参考图10，第三实施例为在第一实施例任意一种神经调控系统的基础上，增加第二采集模块110a，第二采集模块110a采集第二脑电信号；在第一脑电信号和第二脑电信号被诊断为异常的情况下，第一控制模块300接收第一指令和第二指令；第一控制模块300将第一指令发送至第一刺激模块200，第一刺激模块200接收到第一指令后，向第一脑区释放第一电刺激；第一控制模块300将第二指令发送至第二刺激模块400，第二刺激模块400接收到第二指令后，向第二脑区释放第二电刺激。也即医生等专业人士根据第一脑电信号和第二脑电信号的综合异常情况确定第一指令和第二指令，然后操作APP，以使第一指令和第二指令下发给第一控制模块300。
或者，在第一脑电信号被诊断为异常的情况下，第一控制模块300接收第一指令；在第二脑电信号被诊断为异常的情况下，第一控制模块300接收第二指令；第一控制模块300将第一指令发送至第一刺激模块200，第一刺激模块200接收到第一指令后，向第一脑区释放第一电刺激；第一控制模块300将第二指令发送至第二刺激模块400，第二刺激模块400接收到第二指令后，向第二脑区释放第二电刺激。也即医生等专业人士根据第一脑电信号的异常情况，确定向第一脑区释放第一电刺激，根据第二脑电信号的异常情况，确定向第二脑区释放第二电刺激。可以理解的是，在该种实施方式下，第一脑电信号和第一电刺激优选针对同一大脑头皮区域，例如采集的第一脑电信号为后脑区域的信号，则针对后脑区域释放第一电刺激。同样地，第二脑电信号和第二电刺激优选针对同一大脑头皮区域。
应当理解的是，第一采集模块100和第二采集模块110a采集的是大脑头皮上不同区域的脑电信号。医生可以根据第一脑电信号和第二脑电信号的综合判断结果，确定第一刺激模块200和第二刺激模块400的参数，也可以设置为不同或者相同。当然，医生也可以根据第一脑电信号的情况，确定第一刺激模块200的参数，根据第二脑电信号的情况，确定第二刺激模块400的参数。
优选地，第一采集模块100可以采集第一脑区的第一脑电信号，第二采集模块110a可以采集第二脑区的第二脑电信号，然后医生根据该第一脑电信号确定第一刺激模块200施加给第一脑区的第一电刺激的参数，根据该第二脑电信号确定第二刺激模块400施加给第二脑区的第二电刺激的参数，从而实现有针对性的释放电刺激，增加诊治精准度。
当然，还可以设置第三采集模块和第四采集模块......等，再次不再赘述。
相应地，该终端还可以包括第二获取单元，第二获取单元获取第二脑电信号；医生诊断第一脑电信号和第二脑电信号异常时，操作第一按钮（也即第一发送单元）发送第一指令；操作第二按钮（也即第二发送单元）发送第二指令。
或者医生诊断第一脑点信号异常时，操作第一按钮（也即第一发送单元）发送第一指令；医生诊断第二脑点信号异常时，操作第二按钮（也即第二发送单元）发送第二指令。上述第二获取单元针对设置有第二采集模块110a的神经调控系统，具体方案同第一获取单元，例如可以在APP上设置第六按钮，用于控制第二脑电信号的获取。
第四实施例
请参考图9，本发明第五实施例提供一种可穿戴神经调控装置900，包括可穿戴支架和第一实施例至第三实施例中的任意一种神经调节系统；神经调节系统设置在可穿戴支架上。
具体地，可穿戴支架包括环形头箍带910、连接带920和延伸带930；连接带920的两端均与环形头箍带910的一侧固定连接，延伸带930与环形头箍带910的另一侧固定连接；第一采集模块100包括电连接的脑电采集电极120和数据采集单元110，第一刺激模块200和第二刺激模块400均包括电连接的刺激电路410和刺激电极420；数据采集单元110、刺激电路410和第一控制模块300均集成在环形头箍带910的内侧；脑电采集电极120设置在环形头箍带910的内侧或者延伸带930的内侧；刺激电极420设置在环形头箍带910的内侧或者连接带920的内侧。
以下列举一种第一采集模块100中的脑电采集电极120的数量为三个的具体实施方式，其中两个脑电采集电极120设置在环形头箍带910的内侧面上，用于采集用户前额叶处的电信号；另一个脑电采集电极120设置在延伸带930上，用于采集用户左耳乳突处的电信号。脑电刺激电极120包括脑电电极、参考电极和地电极三种，上述三个脑电刺激电极120分别为脑电电极、参考电极和地电极。
以下列举一种第一刺激模块200和第二刺激模块400的刺激电极420的数量均为两个的具体实施方式，第一刺激模块200的两个刺激电极420分别设置连接带920内侧的两端；第二刺激模块400的两个刺激电极420均设置在环形头箍带910的内侧。刺激电极420可以采用银或者氯化银等材料制成，刺激电极420能够直接接触头皮，使用时不需要上导电胶。
具体地，数据采集单元110、刺激电路410和第一控制模块300集成在一块电路板940上，该电路板940安装在环形头箍带910的内侧，对应患者后脑的区域。当然，针对包括第二控制模块500、第三控制模块500a、无线模块700、电源模块和隔离模块600等模块的神经调控系统，其中除了刺激模块中的刺激电极420和采集模块中的脑电采集电极120之外，其余部件全部集成在一块电路板940上。增加可穿戴神经调控装置900的结构紧凑性，便于患者穿戴。
以上对本发明实施例进行了详细介绍，本文中应用了具体个例对本发明的原理及实施方式进行了阐述，以上实施例的说明只是用于帮助理解本发明的方法及其核心思想；同时，对于本领域的一般技术人员，依据本发明的思想，在具体实施方式及应用范围上均会有改变之处，综上，本说明书内容不应理解为对本发明的限制。

Claims (13)

  1. 一种神经调控系统，其特征在于，包括第一采集模块、第一刺激模块、第一控制模块和第二刺激模块；
    所述第一采集模块、第一刺激模块和第二刺激模块与所述第一控制模块电连接；
    所述第一控制模块接收采集指令，将所述采集指令发送至所述第一采集模块；所述第一采集模块接收到所述采集指令后，采集第一脑电信号；
    在所述第一脑电信号被诊断为异常的情况下，所述第一控制模块接收第一指令和第二指令；
    所述第一控制模块将所述第一指令发送至所述第一刺激模块，所述第一刺激模块接收到所述第一指令后，向第一脑区释放第一电刺激；所述第一控制模块将所述第二指令发送至所述第二刺激模块，所述第二刺激模块接收到所述第二指令后，向第二脑区释放第二电刺激。
  2. 根据权利要求1所述的神经调控系统，其特征在于，还包括第二控制模块和数字隔离单元，所述第二控制模块连接在所述第一控制模块和所述第二刺激模块之间；所述数字隔离单元连接在所述第一控制模块和所述第二控制模块之间；
    所述第一控制模块将所述第二指令发送至所述数字隔离单元；所述数字隔离单元接收到所述第二指令后，对所述第二指令进行电流干扰隔离处理，将隔离处理后的所述第二指令发送至所述第二控制模块；所述第二控制模块接收隔离处理后的所述第二指令后，将隔离处理后的所述第二指令发送至所述第二刺激模块。
  3. 根据权利要求1或2所述的神经调控系统，其特征在于，还包括无线模块，所述无线模块与所述第一控制模块电连接；所述无线模块用于在接收到所述第一指令和所述第二指令后，将所述第一指令和所述第二指令传输至所述第一控制模块。
  4. 根据权利要求2所述的神经调控系统，其特征在于，还包括主供电单元；所述主供电单元用于向所述第一采集模块、第一刺激模块和第一控制模块供电。
  5. 根据权利要求4所述的神经调控系统，其特征在于，还包括辅供电单元和电源隔离单元；所述辅供电单元与所述第二控制模块电连接；所述电源隔离单元连接在所述主供电单元和所述辅供电单元之间；
    所述主供电单元用于向所述辅供电单元提供电能源，所述辅供电单元用于向第二控制模块和第二刺激模块提供电能源；
    所述主供电单元将电能源传输至所述电源隔离单元；所述电源隔离单元接收到所述电能源后，对所述电能源进行电流干扰隔离处理，将隔离处理后的所述电能源传输至所述辅供电单元；所述辅供电单元接收到隔离处理后的所述电能源后，将隔离处理后的所述电能源传输至所述第二控制模块；所述第二控制模块接收到隔离处理后的所述电能源后，将隔离处理后的所述电能源传输至所述第二刺激模块。
  6. 根据权利要求1或2所述的神经调控系统，其特征在于，还包括第三刺激模块，所述第三刺激模块和所述第一控制模块电连接；
    在所述第一脑电信号被诊断为异常的情况下，所述第一控制模块接收第三指令；
    所述第一控制模块将所述第三指令发送至所述第三刺激模块，所述第三刺激模块接收到所述第三指令后，向第三脑区释放第三电刺激。
  7. 根据权利要求1或2所述的神经调控系统，其特征在于，还包括第二采集模块，所述第二采集模块采集第二脑电信号；
    在所述第一脑电信号和第二脑电信号被诊断为异常的情况下，所述第一控制模块接收所述第一指令和第二指令；所述第一控制模块将所述第一指令发送至所述第一刺激模块，所述第一刺激模块接收到所述第一指令后，向第一脑区释放第一电刺激；所述第一控制模块将所述第二指令发送至所述第二刺激模块，所述第二刺激模块接收到所述第二指令后，向第二脑区释放第二电刺激；或者，
    在所述第一脑电信号被诊断为异常的情况下，所述第一控制模块接收所述第一指令；在所述第二脑电信号被诊断为异常的情况下，所述第一控制模块接收所述第二指令；所述第一控制模块将所述第一指令发送至所述第一刺激模块，所述第一刺激模块接收到所述第一指令后，向第一脑区释放第一电刺激；所述第一控制模块将所述第二指令发送至所述第二刺激模块，所述第二刺激模块接收到所述第二指令后，向第二脑区释放第二电刺激。
  8. 根据权利要求1或2所述的神经调控系统，其特征在于，所述第一电刺激和第二电刺激为直流刺激、正弦波刺激、方波刺激或者随机噪声刺激中任意一种；所述第一电刺激和第二电刺激的最大幅度为1.6mA；所述正弦波刺激和方波刺激的频率为0至1000Hz，且调节精度为1Hz。
  9. 根据权利要求1或2所述的神经调控系统，其特征在于，所述第一采集模块包括脑电采集电极和数据采集单元；所述数据采集单元和所述第一控制模块电连接，所述脑电采集电极和所述数据采集单元电连接；
    所述脑电采集电极用于采集第一脑电信号，用于采集第一脑电信号，将第一脑电信号发送至所述数据采集单元；所述数据采集单元接收到第一脑电信号后，将第一脑电信号转换为数字信号并发送至所述第一控制模块。
  10. 根据权利要求9所述的神经调控系统，其特征在于，所述脑电采集电极包括脑电电极、参考电极和地电极。
  11. 根据权利要求1或2所述的神经调控系统，其特征在于，还包括终端，所述终端中安装有应用程序APP；所述APP与所述第一控制模块进行无线通讯；所述终端接收所述第一脑电信号后，将第一脑电信号显示在所述APP上；
    所述终端向所述第一控制模块发送所述第一指令和第二指令。
  12. 一种可穿戴神经调控装置，其特征在于，包括可穿戴支架和权利要求1至11中任一项所述的神经调节系统；所述神经调节系统设置在所述可穿戴支架上。
  13. 根据权利要求12所述的可穿戴神经调控装置，其特征在于，所述可穿戴支架包括环形头箍带、连接带和延伸带；所述连接带的两端均与所述环形头箍带的一侧固定连接，所述延伸带与所述环形头箍带的另一侧固定连接；
    所述第一采集模块包括电连接的脑电采集电极和数据采集单元，所述第一刺激模块和所述第二刺激模块均包括电连接的刺激电路和刺激电极；
    所述数据采集单元、刺激电路和第一控制模块均集成在所述环形头箍带的内侧；所述脑电采集电极设置在所述环形头箍带的内侧或者所述延伸带的内侧；所述刺激电极设置在所述环形头箍带的内侧或者所述连接带的内侧。
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