WO2021089056A1 - SYNTHÈSE DE MONOMÈRE ANHYDRIDE THIOCARBONYLE D'ACIDE β,γ-AMINÉ N-CARBOXYLE, RÉACTION DE POLYMÉRISATION, PRÉPARATION D'UN POLYMÈRE ET SON APPLICATION - Google Patents

SYNTHÈSE DE MONOMÈRE ANHYDRIDE THIOCARBONYLE D'ACIDE β,γ-AMINÉ N-CARBOXYLE, RÉACTION DE POLYMÉRISATION, PRÉPARATION D'UN POLYMÈRE ET SON APPLICATION Download PDF

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Publication number
WO2021089056A1
WO2021089056A1 PCT/CN2020/127637 CN2020127637W WO2021089056A1 WO 2021089056 A1 WO2021089056 A1 WO 2021089056A1 CN 2020127637 W CN2020127637 W CN 2020127637W WO 2021089056 A1 WO2021089056 A1 WO 2021089056A1
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WIPO (PCT)
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substituted
alkyl
unsubstituted
nta
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PCT/CN2020/127637
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English (en)
Chinese (zh)
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刘润辉
周敏
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华东理工大学
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/06—1,3-Thiazines; Hydrogenated 1,3-thiazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/14—Lactams
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/14—Lactams
    • C08G69/16—Preparatory processes
    • C08G69/18—Anionic polymerisation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/14—Lactams
    • C08G69/22—Beta-lactams
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

La présente invention concerne la synthèse d'un monomère anhydride thiocarbonyle d'acide β,γ-aminé N-carboxyle, une réaction de polymérisation, un polymère, un polypeptide, une préparation d'un polymère et d'un dérivé polypeptidique, et son application. Les conditions de préparation des polymères d'acides β- et γ-aminés classiques sont améliorées, les polymères ne sont pas sensibles à l'humidité, une agrégation d'exposition peut être effectuée, et la synthèse d'un polymère séquencé ou mélangé d'acide α-aminé, d'acide β-aminé et d'acide γ-aminé est mise en œuvre ; le polymère d'acide aminé préparé peut être utilisé dans des domaines des matériaux antibactériens, antifongiques, antiviraux, anti-acariens, antitumoraux, d'adhérence cellulaire, d'ingénierie tissulaire, de modification de médicaments, de modification de protéines, de protection de protéines, de synergie médicamenteuse, d'administration de médicaments, d'administration de gènes, d'autoassemblage et analogues.
PCT/CN2020/127637 2019-11-08 2020-11-09 SYNTHÈSE DE MONOMÈRE ANHYDRIDE THIOCARBONYLE D'ACIDE β,γ-AMINÉ N-CARBOXYLE, RÉACTION DE POLYMÉRISATION, PRÉPARATION D'UN POLYMÈRE ET SON APPLICATION WO2021089056A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201911089413.0A CN112778236A (zh) 2019-11-08 2019-11-08 β、γ-氨基酸N-羧基硫代羰基环内酸酐单体的合成、聚合反应、聚合物制备及其应用
CN201911089413.0 2019-11-08

Publications (1)

Publication Number Publication Date
WO2021089056A1 true WO2021089056A1 (fr) 2021-05-14

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PCT/CN2020/127637 WO2021089056A1 (fr) 2019-11-08 2020-11-09 SYNTHÈSE DE MONOMÈRE ANHYDRIDE THIOCARBONYLE D'ACIDE β,γ-AMINÉ N-CARBOXYLE, RÉACTION DE POLYMÉRISATION, PRÉPARATION D'UN POLYMÈRE ET SON APPLICATION

Country Status (2)

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CN (1) CN112778236A (fr)
WO (1) WO2021089056A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113943261A (zh) * 2021-09-15 2022-01-18 中国科学院长春应用化学研究所 一种n-羧基环内酸酐、其制备方法及应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114560829B (zh) * 2022-03-17 2023-08-04 中山大学 一种大环单体的制备方法及其开环聚合反应

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1040793A (zh) * 1988-03-11 1990-03-28 生物研究公司 尿烷保护的氨基酸-n-羧酸酐类的制备方法
CN107987032A (zh) * 2017-11-17 2018-05-04 浙江大学 一种含酚羟基氨基酸-n-硫代羧酸酐单体及其合成和聚合方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10519278B2 (en) * 2016-08-29 2019-12-31 Board Of Supervisors Of Louisiana State University Methods of making polypeptides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1040793A (zh) * 1988-03-11 1990-03-28 生物研究公司 尿烷保护的氨基酸-n-羧酸酐类的制备方法
CN107987032A (zh) * 2017-11-17 2018-05-04 浙江大学 一种含酚羟基氨基酸-n-硫代羧酸酐单体及其合成和聚合方法

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
KRICHELDORF HANS R.: "Über Synthese und Polymerisation alicyclischer β-Isothiocyanatocarbonsäuren und 2,6-Dioxo-perhydro-1,3-thiazine", MAKROMOL. CHEM AND PHYSICS, WILEY, vol. 175, no. 12, 1 December 1974 (1974-12-01), pages 3343 - 3356, XP055811651, ISSN: 0025-116X, DOI: 10.1002/macp.1974.021751202 *
KRICHELDORF HANS R.: "Zur weiteren Kenntnis der Oxazolidindione-(2.5) und Thiazolidindione-(2.5)", CHEMISCHE BERICHTE, VCH, DE, vol. 104, no. 10, 1 October 1971 (1971-10-01), DE, pages 3146 - 3155, XP055811661, ISSN: 0009-2940, DOI: 10.1002/cber.19711041020 *
MARSHALL J. R.: "Some Benxoxaxines and Benxthiaxines derived from Anthranilic Acid", JOURNAL OF THE CHEMICAL SOCIETY, 1 January 1965 (1965-01-01), pages 938 - 940, XP055811656 *
SUGIMOTO H ET AL: "Activation of dithiocarbamate by 2-halothiazolium salts", THE JOURNAL OF ORGANIC CHEMISTRY, vol. 53, no. 10, 13 May 1988 (1988-05-13), pages 2263 - 2267, XP002191974, ISSN: 0022-3263, DOI: 10.1021/jo00245a025 *
ZHOU MIN, XIAO XIMIAN, CONG ZIHAO, WU YUEMING, ZHANG WENJING, MA PENGCHENG, CHEN SHENG, ZHANG HAODONG, ZHANG DANFENG, ZHANG DONGHU: "Water‐Insensitive Synthesis of Poly‐β‐Peptides with Defined Architecture", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, VERLAG CHEMIE, DE, vol. 59, no. 18, 27 April 2020 (2020-04-27), DE, pages 7240 - 7244, XP055811643, ISSN: 1433-7851, DOI: 10.1002/anie.202001697 *
ZHU PING, XUAN RI-CHENG, HU WEI-XIAO: "Preparation of Tetrahydro-1,3-thiazin-2,6-dione", ZHONGGUO YIYAO GONGYE ZAZHI - CHINESE JOURNAL OF PHARMACEUTICALS, SHANGHAI YIYAO GONGYE YANJIUYUAN,SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY, CN, vol. 39, no. 9, 1 September 2008 (2008-09-01), CN, pages 647 - 649, XP055811667, ISSN: 1001-8255 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113943261A (zh) * 2021-09-15 2022-01-18 中国科学院长春应用化学研究所 一种n-羧基环内酸酐、其制备方法及应用
CN113943261B (zh) * 2021-09-15 2023-06-20 中国科学院长春应用化学研究所 一种n-羧基环内酸酐、其制备方法及应用

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