WO2021068255A1 - 一种可步进的给药装置 - Google Patents

一种可步进的给药装置 Download PDF

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Publication number
WO2021068255A1
WO2021068255A1 PCT/CN2019/110869 CN2019110869W WO2021068255A1 WO 2021068255 A1 WO2021068255 A1 WO 2021068255A1 CN 2019110869 W CN2019110869 W CN 2019110869W WO 2021068255 A1 WO2021068255 A1 WO 2021068255A1
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WIPO (PCT)
Prior art keywords
support plate
drug delivery
threaded rod
nut
delivery device
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PCT/CN2019/110869
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English (en)
French (fr)
Inventor
吕丹
詹阳
孙语遥
欧阳雨林
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中国科学院深圳先进技术研究院
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Application filed by 中国科学院深圳先进技术研究院 filed Critical 中国科学院深圳先进技术研究院
Priority to PCT/CN2019/110869 priority Critical patent/WO2021068255A1/zh
Priority to US17/284,761 priority patent/US20220304791A1/en
Publication of WO2021068255A1 publication Critical patent/WO2021068255A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6852—Catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
    • A61B5/6868—Brain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/25—Bioelectric electrodes therefor
    • A61B5/279—Bioelectric electrodes therefor specially adapted for particular uses
    • A61B5/291—Bioelectric electrodes therefor specially adapted for particular uses for electroencephalography [EEG]
    • A61B5/293—Invasive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1585—Needle inserters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A61M2005/1588—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body having means for monitoring, controlling or visual inspection, e.g. for patency check, avoiding extravasation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/46—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for controlling depth of insertion

Definitions

  • the present invention relates to the field of biomedical experimental devices, in particular to a step-by-step drug delivery device.
  • the second is that the administered dose is small, generally a few microliters or even less.
  • a method of central nervous system administration has also been developed, which is mostly used in the response of the target nucleus or brain area to the drug.
  • the internationally recognized method of acute and chronic micro-administration in the brain of experimental animals is the embedded catheter method: among the specific methods, It is necessary to place a tube (catheter) with a suitable diameter and length with an inner core in the target brain area or nucleus in the stereotaxic instrument positioning, and fix the exposed part of the tube on the surface of the skull with dental cement and small screws. After the drug is administered, it is necessary to detect and record the neuron signals, and record the changes in the electrical signals of the neurons through brain drug administration to prove the efficacy or observe the behavioral changes after the drug.
  • the catheter is fixed in this way, it can only be administered to a fixed position.
  • a device of this kind cannot be used to administer medicine to multiple positions, and it cannot achieve a more comprehensive position of medicine; and the current method occupies Too much volume makes it impossible to embed the microelectrode array for signal recording after the catheter is embedded in the brain, which makes it impossible to achieve accurate recording of neuron electrical signals after acute drug administration, for example.
  • the present invention proposes a step-by-step drug delivery device, through which the drug delivery catheter can be stepped, so that the drug delivery operation can be performed on a larger area, and this solution
  • the drug delivery catheter is equipped with an electrode wire for detecting neuron signals, which realizes the integration of drug delivery and signal detection, and can detect the area of drug delivery in a targeted manner, and the signal acquisition is more timely and more targeted. Performance, so that the acquired signal is more accurate.
  • the present invention proposes the following specific embodiments:
  • the embodiment of the present invention provides a step-by-step drug delivery device, which includes: a bearing component, a drug delivery catheter connected to the bearing component, a plurality of wire tubes, a threaded rod, a nut that fits the threaded rod, A signal recorder for recording neuron signals, and a connecting rod for connecting an external stereotaxic instrument;
  • the middle part of the threaded rod is sleeved with a nut, the lower end of the threaded rod contacts the lower inner wall of the carrying assembly, the upper end of the threaded rod penetrates the upper part of the carrying assembly, and the upper end of the threaded rod is provided with
  • a driving structure the bearing assembly is also provided with a limiting member for restricting the rotation of the nut, so that when the threaded rod rotates, the nut can move up and down;
  • the outer wall of the drug delivery catheter is fixedly connected to a plurality of wire tubes in a side-by-side manner; one or more of the wire tubes contain electrode wires for detecting and transmitting neuron signals; the electrode wires are connected to the signal recorder;
  • the nut is fixedly connected to the drug delivery catheter, so that when the nut moves up and down, the drug delivery catheter is driven to move up and down.
  • the bearing assembly includes: a first support plate at the upper end, a second support plate at the lower end, and a column; wherein,
  • Both the first support plate and the second support plate are provided with a pipe connection hole, a rod connection hole, and a column connection hole;
  • the drug delivery catheters fixedly connected to a plurality of wire tubes respectively pass through the catheter connection holes on the first support plate and the second support plate to realize the connection with the carrier assembly;
  • the connecting rods respectively pass through The rod connecting holes on the first support plate and the second support plate realize the fixed connection with the bearing assembly;
  • the uprights respectively pass through the first support plate and the second support plate The connecting hole of the upright post realizes the fixed connection with the carrying component;
  • the first support plate is also provided with a driving hole for accommodating the threaded rod;
  • the second support plate is provided with a groove;
  • the nut is arranged between the first support plate and the second support plate; the length of the threaded rod is longer than or equal to the height between the first support plate and the second support plate;
  • the lower end of the threaded rod passes through the driving hole, and the thread is sleeved until the lower end of the threaded rod contacts the bottom of the groove.
  • a plurality of said uprights are provided; the number of said upright connection holes is equal to or greater than the number of said uprights.
  • the bearing assembly includes: a first support plate at the upper end, a second support plate at the lower end, a third support plate at the middle, and a column; wherein,
  • the first support plate, the second support plate, and the third support plate are all provided with a pipe connection hole, a rod connection hole, and a column connection hole;
  • the drug delivery catheters fixedly connected to a plurality of line tubes respectively pass through the catheter connection holes of the first support plate, the second support plate and the third support plate to realize the connection with the carrier assembly;
  • the connecting rods respectively pass through the rod connecting holes on the first support plate, the second support plate, and the third support plate to achieve a fixed connection with the carrier assembly;
  • the uprights respectively pass through the upright connection holes on the first supporting plate, the second supporting plate and the third supporting plate to realize a fixed connection with the carrying assembly;
  • Both the first support plate and the third support plate are provided with driving holes for accommodating the threaded rod
  • the nut is arranged between the first support plate and the third support plate; the length of the threaded rod is longer than or equal to the height between the first support plate and the second support plate;
  • the threaded rods respectively pass through the driving holes on the first supporting plate and the third supporting plate, and the lower end of the threaded rod is blocked by the second supporting plate, and the nut is sleeved on all the driving holes.
  • the lower end of the threaded rod is further provided with a head; wherein the cross-sectional area of the head is larger than the cross-sectional area of the threaded part in the threaded rod.
  • the nut has a polygonal shape
  • the upright is a square
  • the limiting member includes one or more uprights.
  • the driving structure includes: a screw cross slot or a screw slot.
  • the signal recorder is fixed on the carrier assembly in an adhesive manner; the drug delivery catheter fixedly connected to a plurality of line tubes is fixed to the nut in an adhesive manner connection.
  • the line tube is a silicon tube.
  • connection between the electrode wire and the signal recorder is encapsulated by applying silver paint.
  • the step-by-step drug delivery device proposed by this solution can realize the stepping of the drug delivery catheter, so that the drug delivery operation can be performed on a larger area.
  • the drug delivery catheter is The electrode wire used to detect neuron signals is added to realize the integration of drug delivery and signal detection, and can detect the area of drug delivery in a targeted manner. The signal acquisition is more timely and more targeted, so that the acquisition The received signal is more accurate.
  • FIG. 1 is a schematic structural diagram of a stepped drug delivery device according to an embodiment of the present invention
  • Figure 2 is a schematic structural diagram of a stepped drug delivery device proposed by an embodiment of the present invention.
  • FIG. 3 is a schematic diagram of an explosive structure of a stepped drug delivery device according to an embodiment of the present invention.
  • FIG. 4 is a schematic diagram of the structure of a drug delivery catheter, a wire tube, and an electrode wire in a stepable drug delivery device according to an embodiment of the present invention
  • FIG. 5 is a schematic diagram of the structure of a threaded rod and a nut in a stepped drug delivery device according to an embodiment of the present invention
  • Fig. 6 is a schematic structural diagram of a signal recorder in a stepable drug delivery device according to an embodiment of the present invention.
  • 6-signal recorder 7-connecting rod; 8-electrode wire.
  • the embodiment of the present invention provides a step-by-step drug delivery device, as shown in Figs. 1-6, comprising: a carrier component 1, and a drug delivery catheter 2 connected to the carrier component 1, a plurality of wire tubes 3, A threaded rod 4, a nut 5 that fits with the threaded rod 4, a signal recorder 6 for recording neuron signals, and a connecting rod 7 for connecting an external stereotaxic instrument;
  • the middle of the threaded rod 4 is sleeved with a nut 5, the lower end of the threaded rod 4 contacts the lower inner wall of the carrying assembly 1, and the upper end of the threaded rod 4 penetrates the upper part of the carrying assembly 1, so
  • the upper end of the threaded rod 4 is provided with a driving structure 41;
  • the bearing assembly 1 is also provided with a limiting member for restricting the rotation of the nut 5, so that when the threaded rod 4 rotates, the up and down of the nut 5 is realized. mobile;
  • the threaded rod 4 is rotated by the driving structure 41, and the threaded rod 4 cannot continue to move downward because its lower end is supported by the inner wall of the lower end of the carrier assembly 1.
  • the threaded part rotates and the nut 5 is also restrained
  • the restriction cannot be rotated, and the rotation of the threaded rod 4 will drive the nut 5 to move up or down, and the drug delivery catheter 2 is fixedly connected to the nut 5, so that the up and down movement of the nut 5 can drive the drug delivery catheter 2 to move up and down, thereby achieving
  • the stepping of the drug delivery catheter 2 is implemented, so that the drug delivery catheter 2 can realize the drug delivery treatment at different positions or different depths under the adjustment of the driving structure 41.
  • the specific limiting member can have many different embodiments.
  • a circular hole that penetrates up and down is drilled on the nut 5.
  • the limiting member can be a cylindrical steel rod, and the limiting member can pass through The round hole restricts the nut 5.
  • it can also be a cylindrical structure that matches the shape of the nut 5, which can also restrain the rotation of the nut 5.
  • a structure with a polygonal shape on the periphery of the nut 5 can also be used for example, using a square column, the rotation of the nut 5 is restricted by a certain side or a certain side of the periphery of the square column against a certain side of the nut 5 to avoid its rotation.
  • the outer wall of the drug delivery catheter 2 is fixedly connected to a plurality of wire tubes 3 in a side-by-side manner; one or more of the wire tubes 3 contain electrode wires 8 for detecting and transmitting neuron signals; the electrode wires 8 are connected The signal recorder 6; the nut 5 is fixedly connected to the drug delivery catheter 2, so that when the nut 5 moves up and down, the drug delivery catheter 2 is driven to move up and down.
  • a wire tube 3 is attached to the periphery of the drug delivery catheter 2, and an electrode wire 8 is contained in the wire tube 3. Signal detection is performed at the same time of drug delivery. After the signal is detected by the subsequent wire electrode 8, the signal will be transmitted to the signal recorder 6 for processing, and can also be transmitted to other devices for further neuron signal analysis.
  • the step of the drug delivery catheter 2 can be realized, so that a larger area can be administered.
  • the drug delivery catheter 2 is additionally equipped with an electrode wire 8 for detecting neuron signals.
  • the integration of drug delivery and signal detection is realized, and the drug delivery area can be detected in a targeted manner, and the signal acquisition is more timely and targeted, so that the acquired signal is more accurate.
  • the carrying assembly 1 includes: a first support plate 11 at the upper end, a second support plate 13 at the lower end, a third support plate 12 at the middle, Column 14; specifically, the column 14 can be used as a limiter to limit the rotation of the nut 5, where,
  • the first support plate 11, the second support plate 13, and the third support plate 12 are all provided with a pipe connection hole, a rod connection hole, and a column connection hole;
  • the drug delivery catheters 2 fixedly connected to the multiple line tubes 3 respectively pass through the first support plate 11, the second support plate 13 and the catheter connection holes of the third support plate 12 to realize the connection with the The connection of the bearing component 1;
  • the connecting rods 7 respectively pass through rod connecting holes on the first support plate 11, the second support plate 13 and the third support plate 12 to achieve a fixed connection with the carrier assembly 1;
  • the pillars 14 respectively pass through the connecting holes of the pillars 14 on the first support plate 11, the second support plate 13 and the third support plate 12 to achieve a fixed connection with the carrier assembly 1;
  • Both the first support plate 11 and the third support plate 12 are provided with driving holes for accommodating the threaded rod 4;
  • the nut 5 is arranged between the first support plate 11 and the third support plate 12; the length of the threaded rod 4 is longer than or equal to the difference between the first support plate 11 and the second support plate 13 Height between
  • the threaded rod 4 passes through the driving holes on the first support plate 11 and the third support plate 12, and the lower end of the threaded rod 4 is blocked by the second support plate 13.
  • the nut 5 is sleeved on the threaded rod 4 in the area between the first support plate 11 and the third support plate 12.
  • the load-bearing assembly 1 includes three layers of support plates, specifically metal plates or polymer material plates, and the column 14 passes through the three layers of support plates to fix the three layers of support plates into a whole.
  • the upright column 14 plays a supporting role, and there may be one or more upright columns 14 as long as the three-layer boards can be stably supported to provide fixed support for other components.
  • the threaded rod 4 passes through the support plate of the upper layer and the support plate of the middle layer until the lower end reaches the support plate of the lowest layer to prevent the threaded rod 4 from continuing to fall.
  • the nut 5 is set between the two upper support plates; the nut 5 is fixed Connect the drug delivery catheter 2;
  • the drug delivery catheter 2 fixedly connected to the plurality of wire tubes 3 passes through the three-layer support plate, and moves based on the up and down movement of the nut 5.
  • the connecting rod 7 which is fixed between the three layers of support plates, it can be cylindrical or cubic (for example, a rectangular parallelepiped, etc.).
  • the connecting rod 7 is used to connect an external device. Specifically, it can be used to connect a stereotaxic device. , In order to accurately locate the follow-up actual operation.
  • the connecting rod 7 can also play the role of supporting the three layers of support plates.
  • the lower end of the threaded rod 4 is also provided with a head (its shape may be similar to the head of a screw or the head of a screw, etc.); The rotation is more stable, and the lowermost support plate is not easily damaged.
  • the cross-sectional area of the head is larger than the cross-sectional area of the threaded part in the threaded rod 4.
  • the head may have a semicircular arc shape or a spherical shape.
  • the nut 5 has a polygonal shape, such as a hexagon, a quadrilateral, a pentagram, etc.
  • the pillar 14 is square
  • the limiting member includes one or more of the pillars 14 .
  • the upright column 14 can be used to withstand one side of the nut 5, thereby restricting the rotation of the nut 5, thereby restricting the nut 5 from moving up and down.
  • the driving structure 41 includes a screw cross groove or a screw slot.
  • a flat-blade screwdriver or a cross-shaped screwdriver can be used to embed in the driving structure 41 and manually rotate, thereby driving the entire threaded rod 4 to rotate.
  • the signal recorder 6 is fixed on the carrier assembly 1 in an adhesive manner; the drug delivery catheter 2 fixedly connected to a plurality of wire tubes 3 The fixed connection with the nut 5 is achieved in an adhesive manner.
  • the wire tube 3 may be a silicon tube.
  • the silicon tube can be made particularly thin, thereby reducing the occupied space as much as possible, which is beneficial to the miniaturization of the entire device, and the impact on the drug delivery area is minimized.
  • connection between the electrode wire 8 and the signal recorder 6 is encapsulated by applying silver paint.
  • Silver paint can achieve better insulation and ensure the smooth transmission of signals.
  • the length of the drug delivery catheter 2 can be set according to the brain area, and the length of the electrode wire 8 can be the same as the length of the drug delivery catheter 2 or slightly longer by 1 mm. Then the drug delivery device (that is, the microelectrode array) is embedded in the brain with dental cement paste, the wire electrode 8 is used for neuron electrical signal recording, and the drug delivery catheter 2 is used for drug delivery, so that it can be used after the drug is administered. Quickly record the changes of neurons
  • the specific load-bearing component 1 can be composed of three PCB (printed circuit board) boards with a length of 7.5mm and a width of 6mm.
  • two copper pillars with different lengths of 0.8mm and 0.6mm are fixed on the upper end.
  • the middle PCB board is also fixed on the two copper posts, the screws (that is, in a specific embodiment of the threaded rod 4) are placed in the upper and middle PCB boards, and the nuts are screwed under the screws 5. Then fix the third PCB board on the long copper pillar and press it on the bottom of the screw (at this time, the head of the screw on the upper PCB board can be used as the driving structure 41) to prevent the bottom of the screw from moving down and making it impossible to step .
  • a holder that is, the connecting rod 7
  • the function of the holder is to fix the entire microelectrode array on the stereotaxic apparatus, so that the microelectrode array can be embedded in the target brain area. Coat the joints between the PCB board and the copper column and holder with epoxy resin, and blow it with a hot air gun until the epoxy resin is discolored and solidified. Be careful not to apply epoxy resin to the screws, otherwise you cannot step.
  • the connector that is, the signal recorder 6
  • the connector that is, the signal recorder 6
  • the connector that is, the signal recorder 6
  • the connector that is, the signal recorder 6
  • the connector that is, the signal recorder 6
  • the connector that is, the signal recorder 6
  • the ground reference wire can be welded to the preset position of the drug delivery catheter 2, and the fly corner of the connector is sealed with AB glue.
  • the specific signal recorder 6 is shown in Fig. 6, which can be an existing device. Its function is to record the electrical signals of neurons.
  • a signal recorder 6 of model A79026-001 can be used, and its DATACODE (Data code) can be 1839.
  • DATACODE Data code
  • other existing signal recording equipment can also be used, as long as it can record the electrical signals of neurons.
  • microelectrode array is buried upside down in the brain of the mouse, and the neuronal signal changes can be recorded after the drug is administered from the drug delivery catheter 2.
  • the bearing assembly 1 includes: a first support plate 11 at the upper end and a first support plate 11 at the lower end.
  • Both the first support plate 11 and the second support plate 13 are provided with a pipe connection hole, a rod connection hole, and a column connection hole;
  • the drug delivery catheters 2 fixedly connected to a plurality of line tubes 3 respectively pass through the catheter connection holes on the first support plate 11 and the second support plate 13 to realize the connection with the carrier assembly 1;
  • the connecting rods 7 respectively pass through the rod connecting holes on the first support plate 11 and the second support plate 13 to achieve a fixed connection with the carrier assembly 1;
  • the uprights 14 respectively pass through the first support The connecting holes of the uprights on the board 11 and the second supporting board 13 realize a fixed connection with the carrying assembly 1;
  • the first support plate 11 is also provided with a driving hole for accommodating the threaded rod 4;
  • the second support plate 13 is provided with a groove;
  • the nut 5 is arranged between the first support plate 11 and the second support plate 13; the length of the threaded rod 4 is longer than or equal to the difference between the first support plate 11 and the second support plate 13 Height between
  • the lower end of the threaded rod 4 passes through the driving hole, and the thread is sleeved until the lower end of the threaded rod 4 contacts the bottom of the groove.
  • the number of the upright connection holes may be equal to or greater than the number of the uprights 14.
  • modules in the device in the implementation scenario can be distributed in the device in the implementation scenario according to the description of the implementation scenario, or can be changed to be located in one or more devices different from the implementation scenario.
  • the modules of the above implementation scenarios can be combined into one module or further divided into multiple sub-modules.

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Abstract

一种可步进的给药装置，包括：承载组件（1），给药导管（2）、线管（3）、螺纹杆（4）、螺母（5）、信号记录器（6）和连接杆（7）；其中，螺纹杆（4）的中部套接有螺母（5），螺纹杆（4）的下端接触承载组件（1）的下部内壁，螺纹杆（4）的上端穿透承载组件（1）的上部，螺纹杆（4）的上端设置有驱动结构；承载组件（1）内还设置有用于限制螺母（5）转动的限位件，以当螺纹杆（4）转动时，实现螺母（5）的上下移动；以当螺母（5）上下移动时，带动给药导管（2）上下移动。通过该装置，可以实现给药导管（2）的步进，从而可以给更大的区域进行给药操作，且在给药导管（2）附加有用于检测神经元信号的电极丝，实现了给药与信号检测的一体化，且可以有针对性的检测给药的区域，信号的获取更及时也更有针对性，从而使得获取到的信号更准确。

Description

一种可步进的给药装置 技术领域
本发明涉及生物医学实验装置领域，特别涉及一种可步进的给药装置。
背景技术
在生物学实验中，实验动物的给药方法有很多，腹腔注射、静脉注射、灌胃等方式。但对于脑部神经和脑疾病的研究来说，以上给药方式存在严重不足：
一是有些药物不能透过血脑屏障，达不到预期效果；
二是给药剂量小，一般为几微升甚至更少。
传统针对实验动物的给药方式在针对脑部神经和脑疾病的方面受到限制。
为此，还研发有中枢神经给药的方式，其多用于目的核团或脑区对药物的反应，目前国际公认的实验动物脑内急慢性微量给药方法为预埋导管法：具体方法中，需要在立体定向仪定位将一合适直径和长度的带内芯的管道(导管)埋置于目的脑区或核团，用牙科水泥和小螺丝将管道的外露部分固定于颅骨表面，此外，在进行给药之后还需要检测以及记录神经元的信号，通过脑部给药记录神经元电信号的变化，以证明药效或是观察给药后行为学变化。
但是这种方式由于导管是固定的，只能针对固定的位置进行给药，一个这种装置无法针对多个位置进行给药，无法实现更全面位置的给药；且目前的这种方式占用了过多的体积，在脑部埋置导管后不能再埋置进行信号记录的微电极阵列，这使得例如急性给药后对神经元电信号的准确记录就无法实现。
由此，目前需要一种更好的给药装置。
发明内容
针对现有技术中的缺陷，本发明提出了一种可步进的给药装置，通过该装置，可以实现给药导管的步进，从而可以给更大的区域进行给药操作，且本方案中在给药导管附加有用于检测神经元信号的电极丝，以此实现了给药与信号检测的一体化，且可以有针对性的检测给药的区域，信号的获取更及时也更有针对性，从而使得获取到的信号更准确。
具体的，本发明提出了以下具体的实施例：
本发明实施例提出了一种可步进的给药装置，包括：承载组件，以及与所述承载组件连接的给药导管、多个线管、螺纹杆、与所述螺纹杆契合的螺母、用于记录神经元信号的信号记录器、和用于连接外接立体定位仪的连接杆；
其中，所述螺纹杆的中部套接有螺母，所述螺纹杆的下端接触所述承载组件的下部内壁，所述螺纹杆的上端穿透所述承载组件的上部，所述螺纹杆的上端设置有驱动结构；所述承载组件内还设置有用于限制所述螺母转动的限位件，以当所述螺纹杆转动时，实现所述螺母的上下移动；
所述给药导管的外壁以并列的方式固定连接多个线管；一个或多个所述线管内容纳有用于检测及传递神经元信号的电极丝；所述电极丝连接所述信号记录器；所述螺母固定连接所述给药导管，以当所述螺母上下移动时，带动所述给药导管上下移动。
在一个具体的实施例中，所述承载组件包括：位于上端的第一支撑板、位于下端的第二支撑板、立柱；其中，
所述第一支撑板与所述第二支撑板上均设置有导管连接孔、杆连接 孔、以及立柱连接孔；
固定连接多个线管的给药导管分别穿过所述第一支撑板上与所述第二支撑板上的所述导管连接孔实现与所述承载组件的连接；所述连接杆分别穿过所述第一支撑板上与所述第二支撑板上的杆连接孔实现与所述承载组件的固定连接；所述立柱分别穿过所述第一支撑板上与所述第二支撑板上的立柱连接孔实现与所述承载组件的固定连接；
所述第一支撑板上还设置有用于容纳所述螺纹杆的驱动孔；所述第二支撑板上设置有凹槽；
所述螺母设置在所述第一支撑板与所述第二支撑板之间；所述螺纹杆的长度长于或等于所述第一支撑板与所述第二支撑板之间的高度；
所述螺纹杆的下端穿过所述驱动孔，套接上所述螺纹，直到所述螺纹杆的下端接触所述凹槽底部。
在一个具体的实施例中，所述立柱设置有多个；所述立柱连接孔的数量等于或大于所述立柱的数量。
在一个具体的实施例中，所述承载组件包括：位于上端的第一支撑板、位于下端的第二支撑板、位于中部的第三支撑板、立柱；其中，
所述第一支撑板、所述第二支撑板、所述第三支撑板均设置有导管连接孔、杆连接孔、以及立柱连接孔；
固定连接多个线管的给药导管分别穿过所述第一支撑板上、所述第二支撑板上以及所述第三支撑板的所述导管连接孔实现与所述承载组件的连接；
所述连接杆分别穿过所述第一支撑板上、所述第二支撑板上以及所述第三支撑板上的杆连接孔实现与所述承载组件的固定连接；
所述立柱分别穿过所述第一支撑板上、所述第二支撑板上以及所述第三支撑板上的立柱连接孔实现与所述承载组件的固定连接；
所述第一支撑板与所述第三支撑板均设置有用于容纳所述螺纹杆的驱动孔；
所述螺母设置在所述第一支撑板与所述第三支撑板之间；所述螺纹杆的长度长于或等于所述第一支撑板与所述第二支撑板之间的高度；
所述螺纹杆分别穿过所述第一支撑板上与所述第三支撑板上的驱动孔，且所述螺纹杆的下端被所述第二支撑板所挡住，所述螺母套接在所述螺纹杆上在所述第一支撑板与所述第三支撑板之间的区域。
在一个具体的实施例中，所述螺纹杆的下端还设置有头部；其中，所述头部的横截面的面积大于所述螺纹杆中带有螺纹部分的横截面的面积。
在一个具体的实施例中，所述螺母为多边形的形状，所述立柱为方形，所述限位件包括一个或多个所述立柱。
在一个具体的实施例中，所述驱动结构包括：螺丝十字槽或者螺丝一字槽。
在一个具体的实施例中，所述信号记录器以粘结的方式固定在所述承载组件上；所述固定连接多个线管的给药导管以粘结的方式实现与所述螺母的固定连接。
在一个具体的实施例中，所述线管为硅管。
在一个具体的实施例中，所述电极丝与所述信号记录器的连接处以涂抹银漆的方式实现封装。
以此，本方案提出的一种可步进的给药装置，通过该装置，可以实现给药导管的步进，从而可以给更大的区域进行给药操作，且本方案中在给药导管附加有用于检测神经元信号的电极丝，以此实现了给药与信号检测的一体化，且可以有针对性的检测给药的区域，信号的获取更及时也更有针对性，从而使得获取到的信号更准确。
附图说明
为了更清楚地说明本发明实施例的技术方案，下面将对实施例中所需要使用的附图作简单地介绍，应当理解，以下附图仅示出了本发明的某些实施例，因此不应被看作是对范围的限定，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他相关的附图。
图1为本发明实施例提出的一种可步进的给药装置的结构示意图；
图2为本发明实施例提出的一种可步进的给药装置的结构示意图；
图3为本发明实施例提出的一种可步进的给药装置的爆炸结构示意图；
图4为本发明实施例提出的一种可步进的给药装置中给药导管与线管以及电极丝的结构示意图；
图5为本发明实施例提出的一种可步进的给药装置中螺纹杆与螺母的结构示意图；
图6为本发明实施例提出的一种可步进的给药装置中信号记录器的结构示意图。
图例说明：
1-承载组件；11-第一支撑板；12-第三支撑板；13-第二支撑板；14-立柱；
2-给药导管；3-线管；
4-螺纹杆；41-驱动结构；
5-螺母；
6-信号记录器；7-连接杆；8-电极丝。
具体实施方式
在下文中，将更全面地描述本公开的各种实施例。本公开可具有各种实施例，并且可在其中做出调整和改变。然而，应理解：不存在将本公开的各种实施例限于在此公开的特定实施例的意图，而是应将本公开理解为涵盖落入本公开的各种实施例的精神和范围内的所有调整、等同物和/或可选方案。
在本公开的各种实施例中使用的术语仅用于描述特定实施例的目的并且并非意在限制本公开的各种实施例。如在此所使用，单数形式意在也包括复数形式，除非上下文清楚地另有指示。除非另有限定，否则在这里使用的所有术语(包括技术术语和科学术语)具有与本公开的各种实施例所属领域普通技术人员通常理解的含义相同的含义。所述术语(诸如在一般使用的词典中限定的术语)将被解释为具有与在相关技术领域中的语境含义相同的含义并且将不被解释为具有理想化的含义或过于正式的含义，除非在本公开的各种实施例中被清楚地限定。
实施例1
本发明实施例提供了一种可步进的给药装置，如图1-6所示，包括：承载组件1，以及与所述承载组件1连接的给药导管2、多个线管3、螺纹杆4、与所述螺纹杆4契合的螺母5、用于记录神经元信号的信号记录器6、和用于连接外接立体定位仪的连接杆7；
其中，所述螺纹杆4的中部套接有螺母5，所述螺纹杆4的下端接触所述承载组件1的下部内壁，所述螺纹杆4的上端穿透所述承载组件1的上部，所述螺纹杆4的上端设置有驱动结构41；所述承载组件1内还设置有用于限制所述螺母5转动的限位件，以当所述螺纹杆4转动时，实现所述螺母5的上下移动；
具体的，通过驱动结构41转动螺纹杆4，螺纹杆4由于其下端被承载组件1的下端的内壁顶住，无法继续向下移动，由此，螺纹部分转动，而螺母5也被限位件所限制不能转动，而螺纹杆4转动，会驱动螺母5向上或者向下移动，而给药导管2固定连接该螺母5，从而在螺母5的上下移动可以带动给药导管2上下移动，从而实现了给药导管2的步进，以此给药导管2可以在驱动结构41的调节下实现不同位置或者不同深度位置的给药处理。
具体的限位件可以有多种不同的实施例，例如在螺母5上还钻有上下贯通的圆孔，以此情况下，限位件可以为圆柱形钢杆，该限位件以穿过圆孔的方式对螺母5进行限制，此外，还可以为与螺母5的形状匹配的筒状结构，同样可以起到约束螺母5转动的效率，此外，还可以利用螺母5外围为多边形形状的结构，采用例如方形柱的方式，通过方形柱外围的某一边或某一面抵住螺母5的某一边的方式对螺母5的转动进行限制，避免其转动。
所述给药导管2的外壁以并列的方式固定连接多个线管3；一个或多个所述线管3内容纳有用于检测及传递神经元信号的电极丝8；所述电极丝8连接所述信号记录器6；所述螺母5固定连接所述给药导管2，以当所述螺母5上下移动时，带动所述给药导管2上下移动。
为了能第一时间在就能对脑区中给药位置的神经元信号进行检测，为此，在给药导管2的外围附着线管3，线管3中容纳有电极丝8，以此在给药的同时进行信号的检测，后续电极丝8检测到信号之后会传递到信号记录器6中进行处理，以及还可以传递到其他的装置进行进一步的神经元信号的分析。
通过本该装置，可以实现给药导管2的步进，从而可以给更大的区域进行给药操作，且本方案中在给药导管2附加有用于检测神经元信号的电极丝8，以此实现了给药与信号检测的一体化，且可以有针对性的检测给药的区域，信号的获取更及时也更有针对性，从而使得获取到的信号更准确。
在一个具体的实施例中，如图1-3所示，所述承载组件1包括：位于上端的第一支撑板11、位于下端的第二支撑板13、位于中部的第三支撑板12、立柱14；具体的该立柱14就可以作为限位件以限制螺母5的转动，其中，
所述第一支撑板11、所述第二支撑板13、所述第三支撑板12均设置有导管连接孔、杆连接孔、以及立柱连接孔；
固定连接多个线管3的给药导管2分别穿过所述第一支撑板11上、所述第二支撑板13上以及所述第三支撑板12的所述导管连接孔实现与所述承载组件1的连接；
所述连接杆7分别穿过所述第一支撑板11上、所述第二支撑板13上以及所述第三支撑板12上的杆连接孔实现与所述承载组件1的固定连接；
所述立柱14分别穿过所述第一支撑板11上、所述第二支撑板13上以及所述第三支撑板12上的立柱14连接孔实现与所述承载组件1的固定连接；
所述第一支撑板11与所述第三支撑板12均设置有用于容纳所述螺纹杆4的驱动孔；
所述螺母5设置在所述第一支撑板11与所述第三支撑板12之间；所述螺纹杆4的长度长于或等于所述第一支撑板11与所述第二支撑板13之间的高度；
所述螺纹杆4分别穿过所述第一支撑板11上与所述第三支撑板12上的驱动孔，且所述螺纹杆4的下端被所述第二支撑板13所挡住，所述螺母5套接在所述螺纹杆4上在所述第一支撑板11与所述第三支撑板12之间的区域。
具体的，在该实施例中，承载组件1包括3层支撑板，具体的可以为金属板或者高分子材料板，立柱14穿过这三层支撑板将这三层支撑板固定连接成为一个整体，立柱14起到支撑作用，立柱14可以有一个或多个， 具体的只要能稳定支撑起这三层板，为其他的组件提供固定支撑。
螺纹杆4穿过上层的支撑板与中层的支撑板，直到下端顶到最下一层支撑板上，防止螺纹杆4继续下降，螺母5设置在上面的两层支撑板之间；螺母5固定连接给药导管2；
固定连接多个线管3的给药导管2穿过这三层支撑板，基于螺母5的上下移动而移动。
至于连接杆7一则固定在这三层支撑板之间，可以为圆柱形或者立方体(例如可以为长方体等等)，连接杆7用于连接外接设备，具体的，可以用来连接立体定位仪，以便后续实际操作时准确定位。连接杆7也可以起到支撑这三层支撑板的作用。
在一个具体的实施例中，为了更稳定的转动螺纹杆4，所述螺纹杆4的下端还设置有头部(其形状可以类似螺丝的头部或者螺钉的头部等等)；其中，为了更稳定的转动，且不容易破坏掉最下层的支撑板，所述头部的横截面的面积大于所述螺纹杆4中带有螺纹部分的横截面的面积。
更具体的，头部可以为半圆弧形的形状或者球形。
具体的，所述螺母5为多边形的形状，例如可以为6边形，4边形，5边形等等，所述立柱14为方形，所述限位件包括一个或多个所述立柱14。通过立柱14可以顶住螺母5的某一边，从而限制螺母5的转动，从而约束螺母5上下移动。
为了减少其他设备，避免占用更大的空间，所述驱动结构41包括：螺丝十字槽或者螺丝一字槽。
以此，在具体的驱动时，可以利用一字型螺丝刀或者十字形螺丝刀嵌入到驱动结构41中，以手动的方式进行转动，进而驱动整个螺纹杆4转动。
在一个具体的实施例中，为了更简单可靠的实现连接，所述信号记录 器6以粘结的方式固定在所述承载组件1上；所述固定连接多个线管3的给药导管2以粘结的方式实现与所述螺母5的固定连接。
在一个具体的实施例中，如图4所示，所述线管3可以为硅管。通过硅管可以做到特别细，从而尽可能减少占用的空间，利于整个装置的微小化，以及尽可能减少对给药区域的影响。
在一个具体的实施例中，为了更好的进行信号的传递，所述电极丝8与所述信号记录器6的连接处以涂抹银漆的方式实现封装。通过银漆可以实现更好的绝缘，保证信号的顺利传递。
在一个具体的实施例中，给药导管2的长度可根据脑区自行设定，电极丝8的长度可以与给药导管2长度一致或稍长1mm。然后将该给药装置(也即微电极阵列)埋置在脑中用牙科水泥糊牢，电极丝8用于神经元电信号记录，给药导管2用于给药，这样可以在给药之后迅速的记录到神经元的变化情况
具体的承载组件1中可以由三块长度为7.5mm，宽度为6mm的PCB(印刷电路板)板组成，此外用两根分别为0.8mm和0.6mm长度不等的铜柱固定在位于上端的PCB板上，将中间的PCB板也固定在两根铜柱上，将螺丝(也即螺纹杆4的一个具体实施例中)从放入上面与中间的PCB板中，在螺丝下方旋上螺母5。再将第三片PCB板固定在长铜柱上，压在螺丝的底部上(此时位于上层PCB板螺丝的头部可以作为驱动结构41)，以防止螺丝的底部下移以使得无法步进。
再在三层PCB板上插入holder(也即连接杆7)，holder作用是将整个微电极阵列固定在立体定位仪上，便于将微电极阵列埋入目标脑区。将PCB板与铜柱和holder的连接处涂上环氧树脂，用热风枪吹至环氧树脂胶变色凝固。注意不要将环氧树脂涂到螺丝上，否则无法步进。
在给药导管2外侧壁涂上AB胶，将9根长度为1.2cm硅管，粘附在 给药导管2外侧，硅管尽量环绕给药导管2四周。将给药导管2插入3层PCB板，再用AB胶将螺母5和给药导管2粘在一起，AB胶切勿粘到螺丝上。
AB胶干后将connector(也即信号记录器6)粘在三层PCB板的侧面上。将准备好的四股电极丝8插到硅管中，将电极丝8四根单股丝连接信号记录器6蝇角上，四根电极丝8连接上信号记录器6相邻的四个蝇角后涂好银漆，还可以将地线参考线焊到给药导管2的预设位置上，用AB胶将connector的蝇角封好。
具体的信号记录器6如图6所示，可以为目前已有的设备，其作用是用于记录神经元的电信号，例如可以采用型号为A79026-001型号的信号记录器6，其DATA CODE(数据码)可以为1839。当然也可以选用其他已有的信号记录设备，只要能记录神经元的电信号即可。
最后，将微电极阵列倒置埋入小鼠脑中，从给药导管2给药后可记录神经元信号的变化情况。
实施例2
该实施例2与前述实施例1的除了所述承载组件1以外，其他的部分相同，具体的，在该实施例中，所述承载组件1包括：位于上端的第一支撑板11、位于下端的第二支撑板13、立柱14；其中，
所述第一支撑板11与所述第二支撑板13上均设置有导管连接孔、杆连接孔、以及立柱连接孔；
固定连接多个线管3的给药导管2分别穿过所述第一支撑板11上与所述第二支撑板13上的所述导管连接孔实现与所述承载组件1的连接；所述连接杆7分别穿过所述第一支撑板11上与所述第二支撑板13上的杆连接孔实现与所述承载组件1的固定连接；所述立柱14分别穿过所述第一支撑板11上与所述第二支撑板13上的立柱连接孔实现与所述承载组件1的固定连接；
所述第一支撑板11上还设置有用于容纳所述螺纹杆4的驱动孔；所述第二支撑板13上设置有凹槽；
所述螺母5设置在所述第一支撑板11与所述第二支撑板13之间；所述螺纹杆4的长度长于或等于所述第一支撑板11与所述第二支撑板13之间的高度；
所述螺纹杆4的下端穿过所述驱动孔，套接上所述螺纹，直到所述螺纹杆4的下端接触所述凹槽底部。
具体的，在该实施例2中，只设置有两支撑板，为了保证螺纹杆4的转动的稳定性，其下端不至于滑动或移动，设置有凹槽，对螺纹杆4的下端进行限位。
此外，所述立柱14设置有多个；所述立柱连接孔的数量可以等于或大于所述立柱14的数量。
本领域技术人员可以理解附图只是一个优选实施场景的示意图，附图中的模块或流程并不一定是实施本发明所必须的。
本领域技术人员可以理解实施场景中的装置中的模块可以按照实施场景描述进行分布于实施场景的装置中，也可以进行相应变化位于不同于本实施场景的一个或多个装置中。上述实施场景的模块可以合并为一个模块，也可以进一步拆分成多个子模块。
上述本发明序号仅仅为了描述，不代表实施场景的优劣。
以上公开的仅为本发明的几个具体实施场景，但是，本发明并非局限于此，任何本领域的技术人员能思之的变化都应落入本发明的保护范围。

Claims (10)

  1. 一种可步进的给药装置，其特征在于，包括：承载组件，以及与所述承载组件连接的给药导管、多个线管、螺纹杆、与所述螺纹杆契合的螺母、用于记录神经元信号的信号记录器、和用于连接外接立体定位仪的连接杆；
    其中，所述螺纹杆的中部套接有螺母，所述螺纹杆的下端接触所述承载组件的下部内壁，所述螺纹杆的上端穿透所述承载组件的上部，所述螺纹杆的上端设置有驱动结构；所述承载组件内还设置有用于限制所述螺母转动的限位件，以当所述螺纹杆转动时，实现所述螺母的上下移动；
    所述给药导管的外壁以并列的方式固定连接多个线管；一个或多个所述线管内容纳有用于检测及传递神经元信号的电极丝；所述电极丝连接所述信号记录器；所述螺母固定连接所述给药导管，以当所述螺母上下移动时，带动所述给药导管上下移动。
  2. 如权利要求1所述的一种可步进的给药装置，其特征在于，所述承载组件包括：位于上端的第一支撑板、位于下端的第二支撑板、立柱；其中，
    所述第一支撑板与所述第二支撑板上均设置有导管连接孔、杆连接孔、以及立柱连接孔；
    固定连接多个线管的给药导管分别穿过所述第一支撑板上与所述第二支撑板上的所述导管连接孔实现与所述承载组件的连接；所述连接杆分别穿过所述第一支撑板上与所述第二支撑板上的杆连接孔实现与所述承载组件的固定连接；所述立柱分别穿过所述第一支撑板上与所述第二支撑板上的立柱连接孔实现与所述承载组件的固定连接；
    所述第一支撑板上还设置有用于容纳所述螺纹杆的驱动孔；所述第二支撑板上设置有凹槽；
    所述螺母设置在所述第一支撑板与所述第二支撑板之间；所述螺纹杆的长度长于或等于所述第一支撑板与所述第二支撑板之间的高度；
    所述螺纹杆的下端穿过所述驱动孔，套接上所述螺纹，直到所述螺纹杆的下端接触所述凹槽底部。
  3. 如权利要求2所述的一种可步进的给药装置，其特征在于，所述立柱设置有多个；所述立柱连接孔的数量等于或大于所述立柱的数量。
  4. 如权利要求1所述的一种可步进的给药装置，其特征在于，所述承载组件包括：位于上端的第一支撑板、位于下端的第二支撑板、位于中部的第三支撑板、立柱；其中，
    所述第一支撑板、所述第二支撑板、所述第三支撑板均设置有导管连接孔、杆连接孔、以及立柱连接孔；
    固定连接多个线管的给药导管分别穿过所述第一支撑板上、所述第二支撑板上以及所述第三支撑板的所述导管连接孔实现与所述承载组件的连接；
    所述连接杆分别穿过所述第一支撑板上、所述第二支撑板上以及所述第三支撑板上的杆连接孔实现与所述承载组件的固定连接；
    所述立柱分别穿过所述第一支撑板上、所述第二支撑板上以及所述第三支撑板上的立柱连接孔实现与所述承载组件的固定连接；
    所述第一支撑板与所述第三支撑板均设置有用于容纳所述螺纹杆的驱动孔；
    所述螺母设置在所述第一支撑板与所述第三支撑板之间；所述螺纹杆的长度长于或等于所述第一支撑板与所述第二支撑板之间的高度；
    所述螺纹杆分别穿过所述第一支撑板上与所述第三支撑板上的驱动孔，且所述螺纹杆的下端被所述第二支撑板所挡住，所述螺母套接在所述螺纹杆上在所述第一支撑板与所述第三支撑板之间的区域。
  5. 如权利要求4所述的一种可步进的给药装置，其特征在于，所述螺纹杆的下端还设置有头部；其中，所述头部的横截面的面积大于所述螺纹杆中带有螺纹部分的横截面的面积。
  6. 如权利要求4所述的一种可步进的给药装置，其特征在于，所述螺母为多边形的形状，所述立柱为方形，所述限位件包括一个或多个所述立柱。
  7. 如权利要求1所述的一种可步进的给药装置，其特征在于，所述驱动结构包括：螺丝十字槽或者螺丝一字槽。
  8. 如权利要求1所述的一种可步进的给药装置，其特征在于，所述信号记录器以粘结的方式固定在所述承载组件上；所述固定连接多个线管的给药导管以粘结的方式实现与所述螺母的固定连接。
  9. 如权利要求1所述的一种可步进的给药装置，其特征在于，所述线管为硅管。
  10. 如权利要求1所述的一种可步进的给药装置，其特征在于，所述电极丝与所述信号记录器的连接处以涂抹银漆的方式实现封装。
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105251117A (zh) * 2015-09-11 2016-01-20 郑州大学 适于动物脑区植入深度动态可调电极
US20170087005A1 (en) * 2014-05-19 2017-03-30 Dongshin University Industry-Academy Cooperation Portable Electronic Moxibustion Therapy Device
CN106618563A (zh) * 2016-11-09 2017-05-10 中国人民解放军第三军医大学 轻型可重复使用的微电极推进器及其埋置方法
CN106983953A (zh) * 2017-04-21 2017-07-28 浙江中医药大学 一种适用于实验大鼠颅内植入的微丝阵列电极及其制备方法
CN110013346A (zh) * 2019-05-13 2019-07-16 山西医科大学 一种用于大鼠脑区给药及神经电信号记录的一体化装置

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170087005A1 (en) * 2014-05-19 2017-03-30 Dongshin University Industry-Academy Cooperation Portable Electronic Moxibustion Therapy Device
CN105251117A (zh) * 2015-09-11 2016-01-20 郑州大学 适于动物脑区植入深度动态可调电极
CN106618563A (zh) * 2016-11-09 2017-05-10 中国人民解放军第三军医大学 轻型可重复使用的微电极推进器及其埋置方法
CN106983953A (zh) * 2017-04-21 2017-07-28 浙江中医药大学 一种适用于实验大鼠颅内植入的微丝阵列电极及其制备方法
CN110013346A (zh) * 2019-05-13 2019-07-16 山西医科大学 一种用于大鼠脑区给药及神经电信号记录的一体化装置

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