WO2021054773A1 - Composition cosmétique ayant une formulation d'émulsions multiples pour la stabilisation d'ingrédient actif et l'accélération de l'absorption cutanée - Google Patents

Composition cosmétique ayant une formulation d'émulsions multiples pour la stabilisation d'ingrédient actif et l'accélération de l'absorption cutanée Download PDF

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WO2021054773A1
WO2021054773A1 PCT/KR2020/012639 KR2020012639W WO2021054773A1 WO 2021054773 A1 WO2021054773 A1 WO 2021054773A1 KR 2020012639 W KR2020012639 W KR 2020012639W WO 2021054773 A1 WO2021054773 A1 WO 2021054773A1
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emulsion
formulation
cosmetic composition
weight
oil phase
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PCT/KR2020/012639
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English (en)
Korean (ko)
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노민주
조영관
오희묵
박현정
김선영
박명삼
이준배
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코스맥스 주식회사
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/066—Multiple emulsions, e.g. water-in-oil-in-water
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/596—Mixtures of surface active compounds

Definitions

  • It relates to a cosmetic composition of a multi-emulsion formulation for stabilizing active ingredients and promoting absorption.
  • Cosmetics are used on the skin to make the skin beautiful and healthy, and there is an increasing demand for cosmetics containing active substances that help skin whitening or wrinkle improvement.
  • Centella asiatica In the cosmetic industry, Centella asiatica, oleanolic acid, flavonoids, polyphenols, isoflavones, etc. are active ingredients that have a positive effect on the skin, but they do not dissolve well in water, ethanol, oil, or have poor stability, so they are not applied in effective concentrations. There are difficulties that cannot be done.
  • Emulsion refers to a liquid-liquid dispersion system in which one or more immiscible liquid phases are dispersed in another liquid phase, and has various size distributions from tens of nanometers to tens of micrometers.
  • a particle average diameter of 3 to 50 nm is referred to as a microemulsion, 50 to 500 nm, a nanoemulsion, and a 1.5 to 100 ⁇ m macroemulsion.
  • One aspect is to provide a cosmetic composition of a multi-emulsion formulation stabilizing poorly soluble physiological components through double emulsification.
  • Another aspect is to provide a composition for delivery of a physiologically active substance with increased skin absorption of the physiologically active substance to the skin.
  • Another aspect is to provide a method of preparing the composition.
  • One aspect provides a cosmetic composition of multiple emulsion formulations.
  • Another aspect provides a composition for delivery of a physiologically active substance to the skin.
  • the composition comprises a first emulsion of W/O or O/W formulation including an aqueous phase and an oil phase; And a second emulsion of a W/O or O/W formulation including an aqueous phase and an oil phase.
  • the second emulsion when the first emulsion is W/O, the second emulsion may be O/W, or when the first emulsion is O/W, the second emulsion may be W/O.
  • first emulsion or the second emulsion may each contain a second emulsion or a first emulsion or particles thereof (eg, aqueous particles or oil particles).
  • the particles in the first emulsion or the second emulsion may each contain a second emulsion or a first emulsion or particles thereof (eg, aqueous particles or oil particles).
  • the O/W formulation emulsion is present in the W/O aqueous phase particles
  • the first emulsion is an O/W formulation
  • the composition includes a first emulsion of a W/O formulation including an aqueous phase and an oil phase, and a second emulsion of an O/W formulation including an aqueous phase and an oil phase, and the O/W formulation 2
  • Components of the oil phase of the emulsion eg, oil, higher fatty alcohol, surfactant, wax and/or intercellular lipid component
  • the composition may be W/O/W.
  • oil-in-water O/W
  • water-in-water emulsion water-in-oil emulsion
  • non-aqueous dispersion refers to a form dispersed in a solvent other than water.
  • the water-receiving part may be one containing a bioactive material, water, and/or polyol.
  • physiologically active substances may refer to a substance capable of imparting useful activities to an individual, for example, skin regeneration, skin anti-aging, skin wrinkles, skin whitening, and the like.
  • skin throughout the specification, substances that are delivered through the skin (eg, transdermal delivery) to produce a systemic effect may also be included.
  • the physiologically active substances are the first physiologically active substances or the second physiologically active substances, respectively, and the physiologically active substances contained in the first emulsion or the second emulsion may be the same component or different components.
  • Bioactive substances described herein are not limited to low molecular weight drugs, but also include biological compounds such as plant extracts, proteins, peptides, enzymes, DNA, RNA, siRNA, antibodies or fragments thereof, vitamins, minerals or combinations thereof. can do.
  • the reactivating substances used are generally selected from the group consisting of: moisturizing agents, whitening agents, anti-wrinkle agents, sunscreen agents, atopy improving or remedies, acne ameliorating or remedies, antioxidants, analgesics, anti-inflammatory agents, anti-infective agents, wounds or scars. Remedy, burn remedy, nutritional supplements, minerals and vitamins.
  • the physiologically active substance may include a poorly soluble substance.
  • the poorly soluble material may mean a material that is not well soluble or has poor stability in water, ethanol, or oil.
  • solubility The meaning of'poorly soluble' will be described in more detail in terms of solubility as follows. USP/NF generally expresses solubility as the volume of solvent required to dissolve 1 gram of a substance at a specific temperature (eg 1 g of aspirin in 300 ml of H2O, 5 ml of ethanol at 25° C.). Solubility can be described using more subjective terms such as those given in Table 1 below.
  • the term “poorly soluble” in the present specification when using water as a solvent, the lower four solubility categories of Table 1, namely, “inadequate solubility”, “low solubility”, “very low solubility” and " Substantially insoluble or insoluble substances may be included.
  • the poorly soluble substances may include centella asiatica, oleanolic acid, flavonoids, polyphenols, isoflavones, and the like.
  • physiologically active substance examples include Centella asiatica extract or fraction, Asiaticoside, madecassic acid, madecassoside, and madecasic acid. acid) and combinations thereof.
  • the physiologically active substance is 0.1 to 30% by weight, 0.1 to 25% by weight, 0.2 to 25% by weight, 0.2 to 20% by weight, 0.2 to 10% by weight, 0.5 based on the total weight of the emulsion composition (first or second emulsion). It may be included in an amount of to 15% by weight, 0.5 to 20% by weight, 0.2 to 30% by weight, or 0.5 to 10% by weight.
  • water component examples include tap water, mineral water, salt water, sea water, deep ocean water, ultrapure water, polar ice-derived water, mineral-containing water, and purified water. Water is blended in any ratio.
  • polyol and “polyhydric alcohol” are used interchangeably and mean an aliphatic compound having two or more hydroxyl groups (-OH).
  • the polyol may be glycerol, glycol, or a combination thereof.
  • the glycerols may be glycerin, diglycerin, polyglycerin, glycerol, glycyl alcohol, or a combination of two or more thereof.
  • the glycerin may be mixed with other commonly used names such as rislin, propane-1,2,3-triol, 1,2,3-propenetriol, and trihydroxypropane.
  • the glycols are propylene glycol, dipropylene glycol, butylene glycol, diethylene glycol, triethylene glycol, hexylene glycol, pentylene glycol, polyethylene glycol, or It may be a combination of two or more thereof.
  • the polyol is, for example, 0.1 to 50% by weight, 0.1 to 40% by weight, 0.1 to 30% by weight, 0.5 to 30% by weight, 0.5 to 30% by weight, based on the total weight of the emulsion composition (first emulsion or second emulsion) , 0.1 to 20% by weight, 0.1 to 15% by weight, 5 to 40% by weight, 5 to 35% by weight, 15 to 40% by weight, or 15 to 35% by weight. If it is less than 0.1% by weight, it cannot fulfill its role as a base material, and if it is included in more than 50% by weight, formulation stability may not be implemented.
  • the oil phase is a first oil phase containing oil, higher fatty alcohol, wax and/or a surfactant; Alternatively, it may be a second oil phase containing oil, higher fatty alcohol, surfactant, wax and/or intercellular lipid component.
  • the first emulsion or the second emulsion may each include either a first oil phase or a second oil phase. More specifically, one of the first emulsion or the second emulsion may include at least a second oil phase.
  • 'higher fatty alcohol' may mean a monohydric alcohol having 6 or more carbon atoms (eg, C6 to C20).
  • the cosmetic composition it may be an oily raw material in the form of a cream as a high-quality alcohol extracted from natural oil or oil.
  • the higher fatty alcohol is lanolin alcohol, behenyl alcohol (Docosanol), beta-sitosterol, cetyl alcohol, stearyl alcohol, Araki Arachidyl alcohol (Eicosanol), octyl dodecanol, oleyl alcohol, isostearyl alcohol, cholesterol, cetostearyl alcohol, cetearyl alcohol ) Or a mixture thereof.
  • the higher fatty alcohol is 2 to 30% by weight, 2 to 15% by weight, 2 to 20% by weight, 4 to 15% by weight, or It may be 4 to 10% by weight.
  • the wax is not limited as long as it is a wax that can be used in the cosmetic composition, but, for example, fatty acid, vegetable wax, mineral wax, synthetic wax, ozokerite, cetyl palmitate, sorbitan palmitate, bead wax, lipid and lipid It may mean a peptide or the like.
  • Waxes are 0.1 to 10% by weight, 0.1 to 8% by weight, 0.1 to 5% by weight, 0.5 to 5% by weight, 0.2 to 1.5% by weight, 1.8 to 4% based on the total weight of the emulsion composition (first or second emulsion) It may be included in a percentage by weight.
  • the oil may be an ester oil, a hydrocarbon oil, a silicone oil, a vegetable oil, or a mixture thereof.
  • the ester oil of the present invention is C12*?*alkyl octanoate, myristyl lactate, cetyl octanoate, isopropyl myristate, and octyldodecyl Myristate, hexyl laurate, di(C12-C13) alkyl malate, myristyl lactate, octyldodecyl stearoyl Stearate (octyldodecyl stearoyl stearate), diisostearyl malate, pentaerythrityl tetraisostearate or diglyceryl triisostearate.
  • the hydrocarbon-based oil may include hydrogenated, hydrogenated PEG-60 castor oil, hydrogenated polyisobutene, or hydrogenated polydecene.
  • the silicone oil is dimethicone, polydimethylsiloxanes (PDMSs), phenyl trimethicones, phenyl dimethicones, phenyl (trimethylsiloxy) diphenylsiloxane.
  • diphenylsiloxanes diphenyl dimethicones, diphenyl dimethicones, diphenyl(methyldiphenyl)trisiloxanes) or (2-phenylethyl)trimethylsiloxysilicates ), such as phenyl silicones, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, heptamethylhexyltrisiloxane, and heptamethyloctyltrisiloxane.
  • Siloxane (heptamethyloctyltrisiloxane), hexamethyldisiloxane (hexamethyldisiloxane), octamethyltrisiloxane (octamethyltrisiloxane), decamethyltetrasiloxane (decamethyltetrasiloxane) or dodecamethylpentasiloxane (dodecamethylpentasiloxane) may be included.
  • the vegetable oil may include shea butter oil, mango butter oil, cocoa water seed butter oil, macadamia nut oil, olive oil, meadow foam seed oil, refined grape seed oil, peach seed oil, or sunflower seed oil.
  • the oil is 1 to 30% by weight, 2 to 30% by weight, 5 to 30% by weight, 2 to 12% by weight, 2 to 10% by weight, 4 to 12% by weight based on the total weight of the emulsion composition (first or second emulsion) It may be included in a ratio of weight%, 10 to 30% by weight, 12 to 30% by weight, or 12 to 20% by weight.
  • the surfactant is not limited as long as it is a surfactant that can be used in the cosmetic composition, but, for example, polyglycerin fatty acid ester, sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene alkyl ether Oil, palm oil fatty acid monoethanolamide, polyoxyethylene hydrogenated castor oil, sodium lauryl sulfate, polyoxyethylene glyceryl pyroglutamate isostearic acid, sodium alkylbenzenesulfonate, polyoxyethylene stearyl ether, dialkyl sulfosuccinic acid, cetyl pyridinium bromide , Chloride-n-octadecyltrimethyl ammonium, monoalkyl phosphoric acid, N-acylsultamic acid, N-acyl glutamine, sucrose fatty acid ester, polyoxyethylene sorbitan monostearate, sodium polyoxyethylene
  • the surfactant is 0.1 to 30% by weight, for example, 0.1 to 25% by weight, 0.1 to 20% by weight, 1 to 30% by weight, based on the total weight of the emulsion composition (first emulsion or second emulsion), It may be included in an amount of 1 to 20% by weight, 1 to 5% by weight, 8 to 30% by weight, 8 to 20% by weight, 10 to 30% by weight, 10 to 20% by weight, or 8 to 15% by weight.
  • intracellular lipid may mean a lipid component present between cells of the stratum corneum.
  • the intercellular lipid component may include ceramide, or a derivative thereof, cholesterol or a derivative thereof, a cholesterol ester, a free fatty acid, and the like.
  • ceramide is used interchangeably with N-acylsphingosine, and may include all compounds consisting of sphingosine and fatty acids. Specific examples of the ceramide may include natural ceramide, synthetic ceramide, or a derivative thereof.
  • the ceramide may include one or more selected from the group consisting of ceramide EOP, ceramide NG, ceramide NS, ceramide NP, ceramide AS, and ceramide AP.
  • the ceramide derivative may include a known derivative having properties similar to ceramide.
  • the ceramide or a derivative thereof, or cholesterol or a derivative thereof, a cholesterol ester, or a free fatty acid, respectively, is 0.01 to 5% by weight, for example, 0.01 to 3% by weight, based on the total weight of the emulsion composition (the first emulsion or the second emulsion), 0.05 to 5% by weight, 0.05 to 3% by weight, 0.01 to 2% by weight, 0.01 to 1% by weight, 0.1 to 5% by weight, 0.1 to 3% by weight, 0.1 to 2% by weight, 0.1 to 1% by weight, or 0.05 It may be included in an amount of to 1% by weight.
  • the W/O formulation emulsion is 5 to 50% by weight, 5 to 40% by weight, 5 to 35% by weight, 5 to 30% by weight, 10 to 40% by weight, 10 to It may be included in an amount of 35% by weight, or 10 to 30% by weight.
  • the emulsion of the O/W formulation is 40 to 95% by weight, 50 to 95% by weight, 55 to 90% by weight, 60 to 90% by weight, 50 to 85% by weight, 60 to the total cosmetic composition It may be included in an amount of to 85% by weight, or 55 to 85% by weight.
  • the composition may have piezoelectric properties.
  • the composition may be a piezoelectric composition or a piezoelectric cosmetic.
  • pieelectric composition or “piezoelectric cosmetic” refers to a material capable of generating a microcurrent when pressure is applied, and a physiologically active substance including ceramide or the like is transferred into the skin by such microcurrent ( Transdermal delivery) can be promoted.
  • the piezoelectric constant of the composition may be, for example, 60 to 150 pC, 60 to 120 pC, or 80 to 110 pC.
  • the cosmetic composition according to one embodiment can be prepared in any formulation conventionally prepared in the art.
  • Exemplary product forms include makeup cosmetics such as lipstick, lip gloss, lip cream, and eye shadow; Hair cosmetics such as hair sticks and pomades; Skin, moisturizing gel, moisturizing cream, emulsion, essence, two-stage essence, serum, lotion, cream, liquid foundation, or a basic cosmetic such as a solid foundation formulation, etc. may be mentioned.
  • Another aspect provides a method of preparing a cosmetic composition of multiple emulsion formulations.
  • the method comprises the steps of preparing a first emulsion of a W/O formulation including an aqueous phase and an oil phase; Preparing a second emulsion of an O/W formulation including an aqueous phase and an oil phase; Including the step of preparing a cosmetic composition of a multi-emulsion formulation comprising the step of preparing a mixed solution of a multi-emulsion formulation by adding the second emulsion or the first emulsion to the first emulsion or the second emulsion and then stirring.
  • a cosmetic composition of a multi-emulsion formulation comprising the step of preparing a mixed solution of a multi-emulsion formulation by adding the second emulsion or the first emulsion to the first emulsion or the second emulsion and then stirring.
  • the aqueous phase may be prepared by mixing the components contained in the aqueous phase and dissolving by heating at a temperature of 40 to 80 °C.
  • the oil phase may be prepared by mixing the components contained in the oil phase and dissolving by heating at 60 to 100 °C.
  • the method comprises the steps of mixing a thickener and/or a preservative in the mixed solution; And/or cooling the reactant to at least 40° C. after the stirring, and then removing air bubbles.
  • composition according to an aspect not only is excellent in stabilization of the physiologically active substance in the formulation, there is an effect of improving the absorption of the physiologically active substance in the skin without damaging the skin barrier.
  • FIG. 1 is an optical microscope photograph of Example 1 and Comparative Example 1.
  • FIG. 1 is an optical microscope photograph of Example 1 and Comparative Example 1.
  • Example 2 is a low-temperature scanning electron microscope photograph of Example 1.
  • FIG. 3 is a wide-angle X-ray scattering graph of Example 1 and Comparative Example 1.
  • Figure 4 is a graph showing the in vitro (in vitro) skin absorption effect of Examples 1 and 2.
  • a W/O type emulsion having the composition (unit: weight %) as shown in Table 2 was prepared. Specifically, after weighing each raw material in a beaker according to the ingredients and contents shown in Table 2, the A phase (oil phase) was dissolved by heating at a temperature of 50 to 80°C, and then gradually in the B phase (aqueous phase) at a temperature of 60°C. Put it in. At this time, the mixture of phase A and B was constantly stirred, cooled to 30° C., cooled, and air bubbles were removed to prepare each W/O type emulsion.
  • An O/W type emulsion having the composition (unit: weight %) as shown in Table 3 was prepared. Specifically, after weighing each raw material in a beaker according to the ingredients and contents shown in Table 3, the A phase (oil phase) was dissolved by heating at a temperature of 50 to 80°C, and then gradually in the B phase (aqueous phase) at a temperature of 60°C. Put it in. At this time, the mixture of phase A and B was constantly stirred, cooled to 30° C., cooled, and air bubbles were removed to prepare respective O/W type emulsions.
  • O/W type emulsion ingredient Content (% by weight) Manufacturing Example 2 Manufacturing Example 3 Manufacturing Example 4 A oil 7 7 7 Behenyl alcohol 6 4 6 Pentaerythrityl tetraethylhexanoate 2.5 2.5 2.5 Beeswax 2 2 2 Dimethicone One One One Shea Butter One One One One cholesterol 0.3 0 0.3 Ceramide 0.3 0 0.3 Glyceryl stearate 0.1 0.1 0.1 B Purified water Appropriate amount Appropriate amount Appropriate amount Polyol 10 10 10 Centella Asiatica One 0 0 0
  • each emulsion and raw material are weighed in a beaker according to the components and contents shown in Table 4.
  • part C thickener
  • part D preservative
  • Example 1 A W/O type emulsion: Preparation Example 1 0 20 20 B O/W type emulsion: Preparation Example 2 99 0 0 O/W type emulsion: Preparation Example 3 0 0 79 O/W type emulsion: Preparation Example 4 0 79 0 C Thickener Appropriate amount Appropriate amount Appropriate amount D antiseptic Appropriate amount Appropriate amount Appropriate amount Appropriate amount Appropriate amount
  • Example 1 In order to find out the properties of the particles of Example 1 and Comparative Example 1, each composition was observed with an optical microscope, and pictures were taken, and are shown in FIG. 1.
  • Figs. 1 and 2 it can be seen that multiple emulsions are formed when a cosmetic composition is prepared by double emulsification by mixing after preparing a W/O type emulsion and an O/W type emulsion.
  • Example 1 a multiphase structure in which the emulsion was present in the emulsion was observed.
  • Comparative Example 1 it was confirmed that no multiphase structure was observed.
  • the moisture feeling refers to the feeling of moisturizing the skin when applied to the skin.
  • Adhesion refers to the feeling that the composition adheres to the skin by applying it to the skin thinly when applied to the skin.
  • Reversal feeling means that the feeling of use is different from when applying the skin for the first time.
  • Example 1 Example 2 Comparative Example 1 Moisture ⁇ ⁇ ⁇ Adhesion ⁇ ⁇ ⁇ Reversal ⁇ ⁇ X Overall satisfaction ⁇ ⁇ ⁇
  • the cosmetic composition having a multi-emulsion structure through double emulsification received high evaluation compared to the general emulsion in adhesion and reversal feeling, and in particular, the cosmetic composition of Example 1 has adhesion and overall satisfaction. Was evaluated higher than in Example 2.
  • the irritation degree of the formulations prepared in Examples 1 to 2 and Comparative Example 1 was evaluated as follows for 20 men and women without skin diseases. After applying 20 ⁇ l of the sample to the entire arm of the testers, the test site was sealed and then applied for 24 hours. 30 minutes and 24 hours after removal of the patch, skin reactions were examined according to the terminology presented in the CTFA guidelines.
  • the skin irritation index (PII) scores of the test subjects obtained according to the criteria were averaged, and if it was less than 1, mild irritation, if it was less than 2, it was evaluated as mild irritation, if it was less than 3.5, it was evaluated as severe irritation.
  • WAXS wide angle X-ray scattering
  • Example 1 the active material was stabilized in the formulation, and only about 1.5 ⁇ -1 peak was observed, indicating the hexagonal packing structure of the emulsion without a precipitation peak. This shows that multiple emulsions through double emulsification can be stably included in the formulation by stabilizing the poorly soluble active material.
  • an artificial film manufactured by Merck Co., Ltd. was placed inside an open glass glass, and after applying an appropriate amount of Examples 1 and 2 on it, respectively, it was sufficiently absorbed. 13 mL of PBS was filled in the acceptor part, and a permeation experiment was conducted at 32°C. After 1, 2, 4, and 8 hours, a portion of the receptor that passed through the artificial membrane was extracted using a PBS solvent, and the concentration of niacinamide was measured through HPLC analysis. HPLC analysis conditions are shown in Table 7 below.
  • Example 4 is a result of evaluating an in vitro skin absorption effect for a cosmetic composition according to an exemplary embodiment.
  • Example 2 not including an intercellular lipid component also exhibited a certain level or higher skin absorption ability.
  • Example 1 In order to evaluate the piezoelectricity of Example 1 and Comparative Example 1, piezoelectric properties were measured using a liquid piezoelectric measuring device (refer to Korean Patent Registration No. 10-1793902).
  • Example 1 and Comparative Example 1 were placed between the electrodes of a liquid piezoelectric measuring device and sampled by moving the motor stage, and then the sample was repeatedly applied with a rotation angle of 10° to apply force. Thereafter, the amount of charge generated by the sample was measured to measure piezoelectric properties, and the results are shown in Table 8 below.
  • Example 1 which is a multi-phase structure, has higher piezoelectricity. Since there are relatively more structures, the movement of molecules is large, so polarization occurs well, and it can be confirmed that piezoelectric properties are high. In addition, this means that the cosmetic composition according to an embodiment can deliver more physiologically active substances.

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Abstract

La présente invention concerne une composition cosmétique ayant une formulation d'émulsions multiples. La composition selon un aspect non seulement présente une excellente stabilisation des substances bioactives dans la formulation, mais également un effet permettant d'améliorer l'absorption cutanée des substances bioactives sans détérioration de la barrière cutanée.
PCT/KR2020/012639 2019-09-18 2020-09-18 Composition cosmétique ayant une formulation d'émulsions multiples pour la stabilisation d'ingrédient actif et l'accélération de l'absorption cutanée WO2021054773A1 (fr)

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KR10-2019-0114958 2019-09-18
KR1020190114958A KR102080459B1 (ko) 2019-09-18 2019-09-18 활성 성분 안정화 및 피부 흡수 촉진을 위한 다중 에멀젼 제형의 화장료 조성물

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Cited By (1)

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WO2022251874A1 (fr) * 2021-05-28 2022-12-01 Mary Kay Inc. Technologie de protection de barrière

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KR102080459B1 (ko) * 2019-09-18 2020-02-24 코스맥스 주식회사 활성 성분 안정화 및 피부 흡수 촉진을 위한 다중 에멀젼 제형의 화장료 조성물
KR102473474B1 (ko) * 2021-12-01 2022-12-02 한국콜마주식회사 W/o/w 에멀젼 화장료 조성물 및 이의 제조방법

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