WO2021044231A3 - Compuestos de curcumina y aminoácidos básicos - Google Patents
Compuestos de curcumina y aminoácidos básicos Download PDFInfo
- Publication number
- WO2021044231A3 WO2021044231A3 PCT/IB2020/057240 IB2020057240W WO2021044231A3 WO 2021044231 A3 WO2021044231 A3 WO 2021044231A3 IB 2020057240 W IB2020057240 W IB 2020057240W WO 2021044231 A3 WO2021044231 A3 WO 2021044231A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- curcumin
- arginine
- compounds
- amino acids
- basic amino
- Prior art date
Links
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 title abstract 12
- 235000012754 curcumin Nutrition 0.000 title abstract 6
- 229940109262 curcumin Drugs 0.000 title abstract 6
- 239000004148 curcumin Substances 0.000 title abstract 6
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 title abstract 6
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 150000001413 amino acids Chemical class 0.000 title 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 abstract 3
- 229930064664 L-arginine Natural products 0.000 abstract 3
- 235000014852 L-arginine Nutrition 0.000 abstract 3
- 239000004475 Arginine Substances 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 2
- 235000009697 arginine Nutrition 0.000 abstract 2
- 230000004054 inflammatory process Effects 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- 230000002195 synergetic effect Effects 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Alternative & Traditional Medicine (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención se refiere a compuesto sólido formado por curcumina y arginina que comprende proporciones molares de 5:1 a 1:5 con propiedades mejoradas de biodisponibilidad; comprende un compuesto sólido de curcumina Y arginina y el uso en padecimientos de inflamación, dolor, rigidez, disminución de la amplitud de movimiento, asi como padecimientos que causan discapacidad por presentar síntomas de dolor, inflamación y rigidez, disminución de la amplitud de movimiento entre otras; Una composición farmacéutica que comprende curcumina y L- arginina con efecto de sinergismo en su actividad terapéutica de la combinación de curcumina y L-arginina donde la relación seleccionada permite obtener un efecto sinérgico en su actividad terapéutica, y donde la relación preferida de curcumina:L-arginina se encuentra entre 5:1 a 1:5.
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PE2022000374A PE20221255A1 (es) | 2019-09-06 | 2020-07-31 | Compuestos de curcumina y aminoacidos basicos |
| US17/640,694 US20220370391A1 (en) | 2019-09-06 | 2020-07-31 | Compounds Comprising Curcumin and Basic Amino Acids |
| ES202290022A ES2913376B2 (es) | 2019-09-06 | 2020-07-31 | Compuestos de curcumina y aminoacidos basicos |
| GB2204938.1A GB2616919A (en) | 2019-09-06 | 2020-07-31 | Compounds comprising curcumin and basic amino acids |
| BR112022004059A BR112022004059A2 (pt) | 2019-09-06 | 2020-07-31 | Compostos compreendendo curcumina e aminoácidos básicos |
| AU2020341121A AU2020341121A1 (en) | 2019-09-06 | 2020-07-31 | Compounds comprising curcumin and basic amino acids |
| CA3153397A CA3153397C (en) | 2019-09-06 | 2020-07-31 | Compounds comprising curcumin and basic amino acids |
| CONC2022/0003583A CO2022003583A2 (es) | 2019-09-06 | 2022-03-25 | Compuestos de curcumina y aminoácidos básicos |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MXMX/A/2019/010692 | 2019-09-06 | ||
| MX2019010692A MX2019010692A (es) | 2019-09-06 | 2019-09-06 | Compuestos de curcumina y aminoácidos básicos. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2021044231A2 WO2021044231A2 (es) | 2021-03-11 |
| WO2021044231A3 true WO2021044231A3 (es) | 2021-06-24 |
Family
ID=74852489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/IB2020/057240 WO2021044231A2 (es) | 2019-09-06 | 2020-07-31 | Compuestos de curcumina y aminoácidos básicos |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220370391A1 (es) |
| AU (1) | AU2020341121A1 (es) |
| BR (1) | BR112022004059A2 (es) |
| CA (1) | CA3153397C (es) |
| CO (1) | CO2022003583A2 (es) |
| ES (1) | ES2913376B2 (es) |
| GB (1) | GB2616919A (es) |
| MX (1) | MX2019010692A (es) |
| PE (1) | PE20221255A1 (es) |
| WO (1) | WO2021044231A2 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2021016108A (es) * | 2021-12-17 | 2023-06-19 | Alparis Sa De Cv | Combinacion farmaceutica para el tratamiento de enfermedades respiratorias infecciosas y enfermedades contraidas por via aerea. |
| CN115569233B (zh) * | 2022-10-17 | 2023-07-14 | 湖南大学 | 既能吸光又能与自由基反应的高效光抑制剂的制备方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140031403A1 (en) * | 2011-04-05 | 2014-01-30 | Van Andel Research Institute | Solid Forms of Curcumin |
| WO2015085351A1 (en) * | 2013-12-12 | 2015-06-18 | Newsouth Innovations Pty Limited | Pharmaconutrient composition |
| EP3437638A1 (en) * | 2017-08-01 | 2019-02-06 | Inpha Duemila S.r.l. | Nervonic acid and curcumin for the treatment of pathologies associated with peripheral nerves trophism alterations |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2010004974A (es) * | 2010-05-04 | 2011-11-23 | Senosiain S A De C V Lab | Combinacion de un aine y un aminoacido. |
| WO2015052568A2 (en) * | 2013-10-07 | 2015-04-16 | Laurus Labs Private Limited | Solid forms of curcumin and derivatives thereof |
-
2019
- 2019-09-06 MX MX2019010692A patent/MX2019010692A/es unknown
-
2020
- 2020-07-31 PE PE2022000374A patent/PE20221255A1/es unknown
- 2020-07-31 ES ES202290022A patent/ES2913376B2/es active Active
- 2020-07-31 GB GB2204938.1A patent/GB2616919A/en active Pending
- 2020-07-31 WO PCT/IB2020/057240 patent/WO2021044231A2/es active Application Filing
- 2020-07-31 BR BR112022004059A patent/BR112022004059A2/pt unknown
- 2020-07-31 US US17/640,694 patent/US20220370391A1/en active Pending
- 2020-07-31 CA CA3153397A patent/CA3153397C/en active Active
- 2020-07-31 AU AU2020341121A patent/AU2020341121A1/en active Pending
-
2022
- 2022-03-25 CO CONC2022/0003583A patent/CO2022003583A2/es unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140031403A1 (en) * | 2011-04-05 | 2014-01-30 | Van Andel Research Institute | Solid Forms of Curcumin |
| WO2015085351A1 (en) * | 2013-12-12 | 2015-06-18 | Newsouth Innovations Pty Limited | Pharmaconutrient composition |
| EP3437638A1 (en) * | 2017-08-01 | 2019-02-06 | Inpha Duemila S.r.l. | Nervonic acid and curcumin for the treatment of pathologies associated with peripheral nerves trophism alterations |
Non-Patent Citations (5)
| Title |
|---|
| GOUD N RAJESH ET AL.: "Fast dissolving eutectic compositions of curcumin", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 439, no. 1-2, 15 December 2012 (2012-12-15), pages 63 - 72, XP055837611, ISSN: 0378-5173, DOI: 10.1016/j.ijpharm. 2012.09.04 5 * |
| HEGGE ANNE BEE ET AL.: "Solid dispersions for preparation of phototoxic supersaturated solutions for antimicrobial photodynamic therapy (aPDT) Studies on curcumin and curcuminoides L", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 83, no. 1, 31 December 2012 (2012-12-31), pages 95 - 105, XP055837617, ISSN: 0939-6411, DOI: 10.1016/j.ejpb. 2012.09.01 1 * |
| KARAGIANNI ANNA ET AL.: "Co-Amorphous Solid Dispersions for Solubility and Absorption Improvement of Drugs: Composition, Preparation, Characterization and Formulations for Oral Delivery", PHARMACEUTICS, vol. 10, 31 August 2018 (2018-08-31), XP055837616, ISSN: 1999-4923, DOI: 10.3390/pharmaceuticsl0030098 * |
| PARVATHY K S ET AL.: "Curcumin–amino acid conjugates: Synthesis, antioxidant and antimutagenic attributes", FOOD CHEMISTRY, vol. 120, no. 2, 15 May 2010 (2010-05-15), pages 523 - 530, XP026853808, ISSN: 0308-8146 * |
| WANG RUONING ET AL.: "Involvement of metabolism-permeability in enhancing the oral bioavailability of curcumin in excipient-free solid dispersions co-formed with piperine", INTERNATIONAL JOURNAL OF PHARMACEUTICS, XP085642904 * |
Also Published As
| Publication number | Publication date |
|---|---|
| GB2616919A (en) | 2023-09-27 |
| ES2913376R1 (es) | 2022-06-15 |
| ES2913376B2 (es) | 2023-07-10 |
| US20220370391A1 (en) | 2022-11-24 |
| CA3153397C (en) | 2023-06-20 |
| BR112022004059A2 (pt) | 2022-05-31 |
| PE20221255A1 (es) | 2022-08-16 |
| ES2913376A2 (es) | 2022-06-01 |
| MX2019010692A (es) | 2022-07-06 |
| AU2020341121A1 (en) | 2022-04-14 |
| WO2021044231A2 (es) | 2021-03-11 |
| GB202204938D0 (en) | 2022-05-18 |
| CA3153397A1 (en) | 2021-03-11 |
| CO2022003583A2 (es) | 2022-04-19 |
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