WO2021036165A1 - 脊髓闭环性电刺激系统 - Google Patents

脊髓闭环性电刺激系统 Download PDF

Info

Publication number
WO2021036165A1
WO2021036165A1 PCT/CN2020/071041 CN2020071041W WO2021036165A1 WO 2021036165 A1 WO2021036165 A1 WO 2021036165A1 CN 2020071041 W CN2020071041 W CN 2020071041W WO 2021036165 A1 WO2021036165 A1 WO 2021036165A1
Authority
WO
WIPO (PCT)
Prior art keywords
electrical stimulation
spinal cord
loop
closed
electrical
Prior art date
Application number
PCT/CN2020/071041
Other languages
English (en)
French (fr)
Inventor
刘耀波
杨丹
杨维
周凯
Original Assignee
苏州大学
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 苏州大学 filed Critical 苏州大学
Priority to US17/606,427 priority Critical patent/US12023493B2/en
Publication of WO2021036165A1 publication Critical patent/WO2021036165A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36003—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of motor muscles, e.g. for walking assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36103—Neuro-rehabilitation; Repair or reorganisation of neural tissue, e.g. after stroke
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/389—Electromyography [EMG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/389—Electromyography [EMG]
    • A61B5/395—Details of stimulation, e.g. nerve stimulation to elicit EMG response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/40—Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/407—Evaluating the spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4848—Monitoring or testing the effects of treatment, e.g. of medication
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/36139—Control systems using physiological parameters with automatic adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/3615—Intensity
    • A61N1/36153—Voltage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36146—Control systems specified by the stimulation parameters
    • A61N1/36167—Timing, e.g. stimulation onset
    • A61N1/36171—Frequency
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0551—Spinal or peripheral nerve electrodes
    • A61N1/0558—Anchoring or fixation means therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36062—Spinal stimulation

Definitions

  • the invention relates to the field of medical devices for treating spinal cord injury, in particular to a closed-loop electrical stimulation system for the spinal cord.
  • the working principle of the stimulation system currently applied to animals with spinal cord injury and patients with spinal cord injury is mainly the training of spinal cord epidural electrical stimulation combined with weight-reducing treadmill to enhance sensory feedback.
  • this working principle is not a closed-loop stimulation generated along a specific neural circuit in the true sense. It is dependent on epidural stimulation and weight loss running training. Once the training is stopped, the recovery of sports function will disappear.
  • an existing stimulation system is to give the rat spinal cord lumbar 2 (L2) and sacral 1 (S1) 40 Hz epidural electrical stimulation and 5-HT receptor agonist after thoracic spinal cord injury in rats.
  • a weight-reducing treadmill trains paralyzed rats.
  • the existing stimulation system combines a weight-reducing treadmill for rehabilitation training.
  • the weight-reducing treadmill has a certain weight-bearing capacity and has an auxiliary effect on the passive walking movement of the animal with spinal cord injury or the paralyzed lower limbs of the patient.
  • This training mode is not simple
  • the electrical stimulation mode cannot explore the characteristics of electrical stimulation signal coding.
  • the frequency of spinal cord epidural electrical stimulation depends on the rehabilitation training methods of animals and patients. When the treadmill speed changes, the corresponding spinal cord epidural electrical stimulation frequency also changes.
  • the purpose of the present invention is to provide a closed-loop spinal cord electrical stimulation system.
  • the closed-loop spinal cord electrical stimulation system of the present invention can deliver a spinal cord sensory-motor nerve loop to subjects after spinal cord injury. Electrophysiological signals can activate and reshape neural circuits after closed-loop electrical stimulation, thereby promoting the recovery of the motor function of the subject's hind limbs.
  • the present invention discloses a spinal cord closed-loop electrical stimulation system, which includes spinal cord epidural electrical stimulation electrodes, leg electrical stimulation electrodes, closed-loop electrical stimulators and controllers, spinal cord epidural electrical stimulation electrodes and leg electrical stimulation electrodes, respectively Connected to the closed-loop electrical stimulator, the controller is electrically connected to the closed-loop electrical stimulator, the spinal cord epidural electrical stimulation electrode is used to implant the spinal cord epidural of the subject and apply the first electrical stimulation to the spinal cord epidural, leg The first electrical stimulation electrode is used to implant the subject’s leg and apply the second electrical stimulation to the leg.
  • the controller is used to send electrical stimulation signals to the closed-loop electrical stimulator.
  • the voltage of the first electrical stimulation is 400-600mV, and The frequency is 10-20Hz, the voltage of the second electrical stimulation is 1V-1.5V, and the frequency is 10-20Hz, the application time of the second electrical stimulation is later than the application time of the first electrical stimulation, and the application time interval is 50ms-60ms.
  • the voltage of the second electrical stimulation is 1V.
  • the application time interval between the second electrical stimulation and the first electrical stimulation is 50 ms.
  • the subject is a mouse.
  • the spinal cord closed-loop electrical stimulation system also includes an electrical stimulation fixing device for fixing mice.
  • the electrical stimulation fixing device includes a base and a mouse torso fixing unit provided on the base.
  • the fixing unit includes a height adjustment component and a fixing component slidably connected above the height adjustment component.
  • the height adjusting component is used for adjusting the height of the fixing unit relative to the base in the vertical direction
  • the fixing component includes a sliding rail slidably connected with the height adjusting component and a fixing belt fixedly connected to the sliding rail and used for wrapping the mouse abdomen.
  • leg electrical stimulation electrode is used to implant the tibial anterior muscle of the leg of the subject.
  • spinal cord epidural electrical stimulation electrode is used to implant the spinal cord epidural of the L2-L4 spinal cord of the subject.
  • the leg electrical stimulation electrode includes an I-shaped substrate, a first contact unit and a first interface unit disposed on the I-shaped substrate, and the first contact unit includes a plurality of electrical stimulation contacts and signal receiving contacts
  • the first interface unit includes a positive interface, a negative interface, and a ground interface, wherein at least one electrical stimulation contact is electrically connected to the positive interface through a wire, and at least one electrical stimulation contact is electrically connected to the negative interface through a wire to form a stimulation circuit; wherein at least one signal The receiving contact is electrically connected to the positive interface through a wire, and at least one signal receiving contact is electrically connected to the negative interface through a wire to form a feedback loop.
  • One of the signal receiving contacts is electrically connected to the ground interface through a wire. Gold leaf on the surface.
  • the length of the I-shaped substrate is between 31-33 mm.
  • each electrical stimulation contact is between 0.45-0.55 ⁇ m, and the distance between two adjacent electrical stimulation contacts is between 0.45-0.55 ⁇ m.
  • the I-shaped substrate is laminated with multiple layers, and the total thickness of the multilayer substrate is between 67-68 ⁇ m.
  • the positive electrode interface, the negative electrode interface and the ground wire interface all include a covering film, the covering film is arranged at intervals, and a reinforcing layer is arranged on the covering film.
  • the thickness of the reinforcing layer is between 0.27-0.33 mm.
  • the spinal cord epidural electrical stimulation electrode includes a T-shaped substrate.
  • the T-shaped substrate includes a horizontal portion and a vertical portion.
  • the horizontal portion is provided with a second interface unit
  • the vertical portion is provided with a second contact at the end away from the horizontal portion.
  • Point unit the vertical part is also provided with a fixing unit for fixing the T-shaped substrate relative to the mouse spine.
  • the second interface unit includes a positive interface, a negative interface and a ground interface
  • the second contact unit includes an extension along the vertical part.
  • the fixing unit includes a plurality of fixing pieces extending along the extension direction of the horizontal portion and symmetrically arranged with respect to the extension direction of the vertical portion.
  • the fixing piece is provided with a communication for fixing the T-shaped substrate extending into the mouse body relative to the mouse spine. hole.
  • the structure of the spinal cord epidural electrical stimulation electrode is the same as the electrode structure in the Chinese patent application number 201820803641.4.
  • the electrical stimulation is applied for 1 hour every day, and the electrical stimulation is performed after every 15 minutes of the application of electrical stimulation at an interval of 10 minutes.
  • a physiological recorder (Biopac) is used to detect the myoelectric signal of the subject after electrical stimulation using the spinal cord closed-loop electrical stimulation system.
  • the physiological recorder is electrically connected to the control unit, and the control unit receives the muscle detected by the physiological recorder. Electrical signals and data processing to analyze the subject’s recovery of motor function.
  • data processing software is used for data processing, and the data processing software is preferably Matalab analysis software.
  • the present invention has at least the following advantages:
  • the present invention provides a closed-loop electrical stimulation system formed by spinal cord epidural electrical stimulation combined with leg electrical stimulation suitable for subjects.
  • the system emits electrophysiological signals that simulate the spinal cord sensory-motor nerve loop.
  • the closed-loop electrical stimulation applied by the system to subjects with spinal cord injury can activate and reshape the neural circuit, thereby Promote the recovery of the motor function of the hind limbs.
  • Fig. 1 is a schematic diagram of the structure of the electrical stimulation fixing device of the present invention
  • Figure 2 is a schematic diagram of the structure of the leg electrical stimulation electrode
  • Figure 3 is a schematic diagram of a cross-sectional structure of a leg electrical stimulation electrode
  • Figure 4 is a schematic diagram of the structure of spinal cord epidural electrical stimulation electrodes
  • Figure 5 is a working principle diagram of the closed-loop electrical stimulation of the spinal cord in mice using the mouse spinal cord closed-loop electrical stimulation system
  • a closed-loop electrical stimulation system for the mouse spinal cord of the present invention includes spinal cord epidural electrical stimulation electrodes, leg electrical stimulation electrodes, closed-loop electrical stimulators, electrical stimulation fixtures and controllers for immobilizing mice, and a controller Preferably it is a computer.
  • Spinal cord epidural electrical stimulation electrodes and leg electrical stimulation electrodes are respectively connected to the closed-loop electrical stimulator, the controller is electrically connected to the closed-loop electrical stimulator, and the spinal cord epidural electrical stimulation electrodes are used to implant the L2-L4 section of the subject
  • the spinal cord is epidural and the first electrical stimulation is applied to the spinal cord.
  • the leg electrical stimulation electrodes are used to implant the leg tibial anterior muscle of the subject and apply the second electrical stimulation to the leg tibial anterior muscle to control
  • the device is used to send electrical stimulation signals to a closed-loop electrical stimulator.
  • the voltage of the first electrical stimulation is 400-600mV and the frequency is 10-20Hz
  • the voltage of the second electrical stimulation is 1V-1.5V and the frequency is 10-20Hz.
  • the application time of the second electrical stimulus is later than the application time of the first electrical stimulus, and the application time interval is 50ms-60ms.
  • the electrical stimulation fixing device (FIG. 1) includes a base 13 and a mouse torso fixing unit set on the base 13.
  • the fixing unit includes a height adjustment assembly 12 and a fixing assembly slidably connected above the height adjustment assembly 12.
  • the height adjustment assembly 12 is used to adjust the height of the fixing unit relative to the base 13 in the vertical direction.
  • the fixing assembly includes a sliding rail 11 slidably connected to the height adjustment assembly 12 and fixedly connected to the sliding rail 11 and used for fixing the abdomen of the mouse. Take 10.
  • the leg electrical stimulation electrode ( Figure 2-3) includes a first substrate 1, a first contact unit and a first interface unit which are respectively implanted on the mouse epidural or lower limb muscle surface.
  • the first substrate 1 is laminated with multiple layers, and the total thickness of the multilayer substrate is between 58-62 ⁇ m. Through the above-mentioned arrangement method, the rigidity of the first substrate 1 can be effectively ensured.
  • the first substrate 1 has an "I" shape, and the vertices of the first substrate 1 are connected by arc transitions.
  • the first contact unit includes a plurality of electrical stimulation contacts 2 and a signal receiving contact 3.
  • the first interface unit includes a positive port 4, a negative port 5, and a ground wire port 6, wherein at least one electrical stimulation contact 2 is electrically connected by a wire Positive interface 4, in which at least one electrical stimulation contact 2 is electrically connected to the negative interface 5 through a wire to form a stimulation circuit; wherein at least one signal receiving contact 3 is electrically connected to the positive interface 4 through a wire, and at least one signal receiving contact 3 is electrically connected through a wire
  • the negative port 5 forms a feedback loop.
  • mice On the basis of realizing electric stimulation to mice, it can also realize synchronous or asynchronous response to stimulation.
  • the signals generated by the mice are collected to effectively observe the state of the mice in real time.
  • a signal receiving contact 3 and an electrical stimulation contact 2 are sequentially arranged along the direction close to the center line of the substrate.
  • the first contact unit set in the epidural area of the mouse includes two electrical stimulation contacts 2 and three signal receiving contacts 3. Each electrical stimulation contact 2 and one signal receiving contact 3 share a contact terminal. .
  • the contact unit set on the surface of the lower limb muscle of the mouse includes two electrical stimulation contacts 2 and three signal receiving contacts 3.
  • the signal receiving contact 3 arranged on the epidural of the mouse and the signal receiving contact 3 arranged on the surface of the lower limb muscle of the mouse, any one of the signal receiving contacts 3 is electrically connected to the ground interface 6 through a wire. In the present invention, it is preferred
  • the ground is arranged in the middle signal receiving contact 3 and is electrically connected to the ground interface 6.
  • the positive port 4, the negative port 5, and the ground wire port 6 all include a cover film, and the cover film is arranged at intervals.
  • a reinforcing layer 7 is arranged above the covering film, and the thickness of the reinforcing layer 7 is between 0.27-0.33 mm.
  • the first substrate 1 is provided with a gold foil 8 for covering its surface.
  • a gold foil 8 By providing the gold foil 8, it has good corrosion resistance and biocompatibility, which can effectively ensure the stability and safety of the long-term implantation of the overall electrode plate. At the same time, the accuracy of the experimental data is effectively guaranteed.
  • the spinal cord epidural electrical stimulation electrode ( Figure 4) has the same structure as the electrode in the Chinese patent application number 201820803641.4.
  • the electrode includes a T-shaped substrate.
  • the T-shaped substrate includes a horizontal part and a vertical part.
  • a second interface is provided on the horizontal part.
  • a second contact unit is provided at the end of the vertical part away from the horizontal part, and a fixing unit for fixing the T-shaped substrate relative to the spine of the mouse is provided on the vertical part.
  • the second interface unit includes a positive interface and a negative Interface and ground interface
  • the second contact unit includes a plurality of stimulation contacts arranged in sequence along the extension direction of the vertical part, wherein at least one stimulation contact is connected to the positive interface through a wire, and at least one stimulation contact is connected to the negative interface through a wire to form A stimulation loop or feedback loop, one of the stimulation contacts is electrically connected to the ground wire interface through a wire
  • the fixing unit includes a plurality of fixing pieces extending along the extension direction of the horizontal portion and symmetrically arranged with respect to the extension direction of the vertical portion.
  • the T-shaped substrate in the mouse body is fixedly arranged with a through hole relative to the spine of the mouse.
  • mice spinal cord closed-loop electrical stimulation system of the present invention to perform closed-loop spinal cord electrical stimulation on mice is as follows:
  • the spinal epidural and leg tibial anterior muscles were implanted into spinal cord epidural electrical stimulation electrodes and leg electrical stimulation electrodes in the L2-L4 segment of spinal cord injury mice with deep anesthesia, and the wound was sutured after the operation.
  • the mouse is fixed in the electrical stimulation fixture, the spinal cord epidural electrical stimulation electrode connector and the leg electrical stimulation electrode connector are respectively connected to the spinal cord stimulation port and leg stimulation port of the closed-loop electrical stimulator.
  • the first electrical stimulation intensity of the spinal cord epidural electrical stimulation electrode is set to 400-600mV, the frequency is 10-20Hz through the controller (computer), and the second electrical stimulation electrode is set to the leg after the first electrical stimulation is sent 50ms Electrical stimulation, the stimulation intensity of the second electrical stimulation is 1V, the frequency is 10-20Hz, and the mice are given closed-loop electrical stimulation training. Stimulate for 1 hour a day, and rest for 10 minutes every 15 minutes of stimulation.
  • FIG. 5 is a diagram of the working principle of the above-mentioned electrical stimulation.
  • the spinal cord epidural (S1) and leg electrical stimulation (S2) are respectively given by the closed-loop electrical stimulator, and the spinal cord can be stimulated by closed-loop electrical stimulation. Adjust the stimulus intensity of S1 and S2 respectively.
  • the mouse is fixed in a mouse immobilizer. In this device, the front and rear limbs of the mouse are suspended, which can eliminate the interference caused by the limbs.
  • the electrical stimulation of the legs activates the neural circuit to guide the legs to produce autonomous movements to enhance sensory feedback. Do not rely on weight loss treadmills to produce passive movement.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physiology (AREA)
  • Rehabilitation Therapy (AREA)
  • Electrotherapy Devices (AREA)

Abstract

本发明涉及一种脊髓闭环性电刺激系统，包括脊髓硬膜外电刺激电极、腿部电刺激电极、闭环性电刺激器和控制器，脊髓硬膜外电刺激电极、腿部电刺激电极分别与闭环性电刺激器连接，控制器与闭环性电刺激器电连接，脊髓硬膜外电刺激电极用于植入受试者的脊髓硬膜外并向脊髓硬膜外施加第一电刺激，腿部电刺激电极用于植入受试者的腿部并向腿部施加第二电刺激，第一电刺激的电压为400-600mV，且频率为10-20Hz，第二电刺激的电压为1V-1.5V，且频率为10-20Hz。本发明的脊髓闭环性电刺激系统可以对脊髓损伤后的受试者发放近似于脊髓感觉-运动神经环路的电生理信号，在闭环性电刺激后可以激活并重塑神经环路，从而促进受试者的后肢的运动功能的恢复。

Description

脊髓闭环性电刺激系统 技术领域
本发明涉及用于治疗脊髓损伤的医疗器械领域，尤其涉及一种脊髓闭环性电刺激系统。
背景技术
脊髓损伤后损伤部位以下的局部环路仍保留了运动的功能，近年的研究表明，脊髓损伤后通过特定频率的脊髓硬膜外电刺激同时结合减重跑步运动训练可以激活脊髓局部神经环路，从而促进实验动物后肢以及患者下肢运动功能的恢复。但是功能性的恢复对于电刺激训练具有依赖性，运动功能的恢复只是短暂性的。而在现有的刺激训练装置中，结合了多种方法模拟闭环性刺激，影响因素众多。而目前国内外尚未出现适用于脊髓损伤闭环性电刺激的系统。
目前应用于脊髓损伤动物及脊髓损伤患者的刺激系统的工作原理主要为脊髓硬膜外电刺激结合减重跑步机增强感觉反馈的训练。但这种工作原理不是真正意义上沿特定神经环路产生的闭环性刺激，对硬膜外刺激及减重跑步训练具有依赖性，一旦停止训练运动功能的恢复也会随之消失。如现有的一种刺激系统是在大鼠胸段脊髓损伤后，给予大鼠脊髓腰2(L2)，骶1(S1)段40Hz的硬膜外电刺激及5-HT受体激动剂，结合减重跑步机对瘫痪的大鼠进行训练。
现有刺激系统结合了减重跑步机进行康复训练，减重跑步机具有一定的承重能力，对脊髓损伤的动物或患者瘫痪的下肢产生被动式的步行运动有辅助作用，这种训练模式不是单纯性的电刺激模式，无法探究电刺激信号编码的特征。同时，脊髓硬膜外的电刺激频率取决于动物及患者康复的训练方法，跑步机速度改变时相应的脊髓硬膜外电刺激频率也发生改变。
综上所述，现有脊髓损伤动物及脊髓损伤患者的刺激系统并未单纯使用电刺激对脊髓损伤进行作用。
发明内容
为解决上述技术问题，本发明的目的是提供一种脊髓闭环性电刺激系统，本发明的脊髓闭环性电刺激系统可以对脊髓损伤后的受试者发放近似于脊髓感觉-运动神经环路的电生理信号，在闭环性电刺激后可以激活并重塑神经环路，从而促进受试者的后肢的运动功能的恢复。
本发明的公开了一种脊髓闭环性电刺激系统，包括脊髓硬膜外电刺激电极、腿部电刺激电极、闭环性电刺激器和控制器，脊髓硬膜外电刺激电极、腿部电刺激电极分别与闭环性电刺激器连接，控制器与闭环性电刺激器电连接，脊髓硬膜外电刺激电极用于植入受试者的脊髓硬膜外并向脊髓硬膜外施加第一电刺激，腿部电刺激电极用于植入受试者的腿部并向腿部施加第二电刺激，控制器用于向闭环性电刺激器发送电刺激信号，第一电刺激的电压为400-600mV，且频率为10-20Hz，第二电刺激的电压为1V-1.5V，且频率为10-20Hz，第二电刺激的施加时间晚于第一电刺激的施加时间，施加时间间隔为50ms-60ms。
优选地，第二电刺激的电压为1V。
优选地，第二电刺激与第一电刺激的施加时间间隔为50ms。
进一步地，受试者为小鼠。
进一步地，脊髓闭环性电刺激系统还包括用于固定小鼠的电刺激固定装置。
进一步地，电刺激固定装置包括底座以及设置在底座上的小鼠躯干固定单元，固定单元包括高度调节组件以及滑动连接在高度调节组件上方的固定组件。高度调节组件用于调节固定单元相对底座在竖直方向上的高度，固定组件包括与高度调节组件滑动连接的滑轨以及固定连接在滑轨上并用于裹附小鼠腹部的固定带。
进一步地，腿部电刺激电极用于植入受试者的腿部胫骨前肌。
进一步地，脊髓硬膜外电刺激电极用于植入受试者的L2-L4节脊髓的脊髓硬膜外。
进一步地，腿部电刺激电极包括工字型基板、设置在工字型基板上的第一触点单元和第一接口单元，第一触点单元包括多个电刺激触点和信号接收触点，第一接口单元包括正极接口、负极接口和地线接口，其中至少一个电刺激触点通过导线电连接正极接口、至少一个电刺激触点通过导线电连接负极接口形成刺激回路；其中至少一个信号接收触点通过导线电连接正极接口、至少一个信号接收触点通过导线电连接负极接口形成反馈回路，其中一个信号接收触点通过导线电连接地线接口，工字型基板上设置有用于覆盖其表面的金箔。
进一步地，工字型基板的长度在31-33㎜之间。
进一步地，电刺激触点设置有三个，每个电刺激触点的直径在0.45-0.55μm之间，相邻两个电刺激触点之间的距离在0.45-0.55μm之间。
进一步地，工字型基板层叠设置有多层，多层基板的总厚度在67-68μm之间。
进一步地，正极接口、负极接口和地线接口均包括覆盖膜，覆盖膜间隔设置，覆盖膜上方设置有补强层。
进一步地，补强层的厚度在0.27-0.33㎜之间。
进一步地，脊髓硬膜外电刺激电极包括T字型基板，T字型基板包括横部和竖部，横部上设置有第二接口单元，竖部远离横部的端部处设置有第二触点单元，竖部上还设置有用于将T字型基板相对小鼠脊椎固定设置的固定单元，第二接口单元包括正极接口、负极接口和地线接口，第二触点单元包括沿竖部延伸方向依次排列的多个刺激触点，其中至少一个刺激触点通过导线连接正极接口，至少一个刺激触点通过导线连接负极接口，形成刺激回路或反馈回路，其中一个刺激触点通过导线电连接地线接口，固定单元包括沿横部延长方向延伸且关于竖部延长方向对称设置的多个固定片，固定片上开设有用于将伸入小鼠体内的T字型基板相对小鼠脊椎固定设置的通孔。本发明中，脊髓硬膜外电刺激电极的结构同申请号为201820803641.4的中国专利中电极结构相同。
进一步地，第一电刺激和第二电刺激施加于受试者时，每天施加电刺激1h，每施加电刺激15min后间隔10min后再进行电刺激。
进一步地，采用生理记录仪(Biopac)检测受试者在使用脊髓闭环性电刺激系统进行电刺激后的肌电信号，生理记录仪与控制单元电连接，控制单元接收生理记录仪所检测的肌电信号并对其进行数据处理，以分析受试者的运动功能恢复情况。
进一步地，采用数据处理软件进行数据处理，该数据处理软件优选为Matalab分析软件。
借由上述方案，本发明至少具有以下优点：
本发明提供了一种适用于受试者的脊髓硬膜外电刺激结合腿部电刺激形成的闭环性电刺激系统，该系统发放出模拟脊髓感觉-运动神经环路的电生理信号，通过本发明的脊髓闭环性电刺激系统所发出的适宜的第一电刺激和第二电刺激的强度和频率，该系统对脊髓损伤的受试者施加的闭环电刺激可以激活并重塑神经环路，从而促进其后肢运动功能的恢复。
上述说明仅是本发明技术方案的概述，为了能够更清楚了解本发明的技术手段，并可依照说明书的内容予以实施，以下以本发明的较佳实施例并配合附图详细说明如后。
附图说明
图1是本发明电刺激固定装置的结构示意图；
图2是腿部电刺激电极的结构示意图；
图3是腿部电刺激电极的剖面结构示意图；
图4是脊髓硬膜外电刺激电极的结构示意图；
图5是使用小鼠脊髓闭环性电刺激系统对小鼠进行脊髓闭环性电刺激的工作原理图；
附图标记说明：
1、第一基板；2、电刺激触点；3、信号接收触点；4、正极接口；5、负极接口；6、地 线接口；7、金箔；8、补强层；10、固定带；11、滑轨、12-高度调节组件；13、底座。
具体实施方式
下面结合附图和实施例，对本发明的具体实施方式作进一步详细描述。以下实施例用于说明本发明，但不用来限制本发明的范围。
实施例1
本发明的一种小鼠脊髓闭环性电刺激系统，包括脊髓硬膜外电刺激电极、腿部电刺激电极、闭环性电刺激器、用于固定小鼠的电刺激固定装置和控制器，控制器优选为计算机。脊髓硬膜外电刺激电极、腿部电刺激电极分别与闭环性电刺激器连接，控制器与闭环性电刺激器电连接，脊髓硬膜外电刺激电极用于植入受试者的L2-L4节脊髓的脊髓硬膜外并向脊髓硬膜外施加第一电刺激，腿部电刺激电极用于植入受试者的腿部胫骨前肌并向腿部胫骨前肌施加第二电刺激，控制器用于向闭环性电刺激器发送电刺激信号，第一电刺激的电压为400-600mV，且频率为10-20Hz，第二电刺激的电压为1V-1.5V，且频率为10-20Hz，第二电刺激的施加时间晚于第一电刺激的施加时间，施加时间间隔为50ms-60ms。
电刺激固定装置(图1)包括底座13以及设置在底座13上的小鼠躯干固定单元，固定单元包括高度调节组件12以及滑动连接在高度调节组件12上方的固定组件。高度调节组件12用于调节固定单元相对底座13在竖直方向上的高度，固定组件包括与高度调节组件12滑动连接的滑轨11以及固定连接在滑轨11上并用于裹附小鼠腹部的固定带10。
腿部电刺激电极(图2-3)包括分别植入小鼠硬膜外或下肢肌肉表面的第一基板1、设置在第一基板1上的第一触点单元和第一接口单元。第一基板1层叠设置有多层，多层基板的总厚度在58-62μm之间，通过上述的设置方式，能够有效地保证第一基板1的刚性。第一基板1的呈“工”字型，第一基板1的各顶点采用圆弧过渡连接。
第一触点单元包括多个电刺激触点2和信号接收触点3，第一接口单元包括正极接口4、负极接口5和地线接口6，其中至少一个电刺激触点2通过导线电连接正极接口4，其中至少一个电刺激触点2通过导线电连接负极接口5形成刺激回路；其中至少一个信号接收触点3通过导线电连接正极接口4、至少一个信号接收触点3通过导线电连接负极接口5形成反馈回路。通过上述的设置方式，电刺激触点2和信号接收触点3分别与正极接口4和负极接口5电连接，在实现对小鼠电刺激的基础上，同时可以实现同步或异步对刺激后小鼠产生的信号进行收集，实时有效地观察小鼠的状态。沿靠近基板中线的方向依次设置信号接收触点3、电刺激触点2。
设置在小鼠硬膜外的第一触点单元包括2个电刺激触点2和3个信号接收触点3，每个电刺激触点2分别和一个信号接收触点3共用一触点端。设置在小鼠下肢肌肉表面的触点单元包括2个电刺激触点2和3个信号接收触点3。设置在小鼠硬膜外的信号接收触点3和设置在小鼠下肢肌肉表面的信号接收触点3，其中任意一个信号接收触点3通过导线电连接地线接口6，本发明中，优选地设置在中间信号接受触点3电连接地线接口6。正极接口4、负极接口5和地线接口6均包括覆盖膜，覆盖膜间隔设置。覆盖膜上方设置有补强层7，补强层7的厚度在0.27-0.33㎜之间。
第一基板1上设置有用于覆盖其表面的金箔8，通过设置有金箔8，具有较好的抗腐蚀能力和生物兼容性，能够有效地保证整体电极板长期植入的稳定性和安全性，同时有效地保证了实验数据的准确性。
脊髓硬膜外电刺激电极(图4)同申请号为201820803641.4的中国专利中电极结构相同，该电极包括T字型基板，T字型基板包括横部和竖部，横部上设置有第二接口单元，竖部远离横部的端部处设置有第二触点单元，竖部上还设置有用于将T字型基板相对小鼠脊椎固定设置的固定单元，第二接口单元包括正极接口、负极接口和地线接口，第二触点单元包括沿竖部延伸方向依次排列的多个刺激触点，其中至少一个刺激触点通过导线连接正极接口，至少一个刺激触点通过导线连接负极接口，形成刺激回路或反馈回路，其中一个刺激触点通过导线电连接地线接口，固定单元包括沿横部延长方向延伸且关于竖部延长方向对称设置的多个固定片，固定片上开设有用于将伸入小鼠体内的T字型基板相对小鼠脊椎固定设置的通孔。
使用本发明的小鼠脊髓闭环性电刺激系统对小鼠进行脊髓闭环性电刺激的方法如下：
1、在深度麻醉的脊髓损伤小鼠L2-L4节段脊髓硬膜外及腿部胫骨前肌分别植入脊髓硬膜外电刺激电极及腿部电刺激电极，手术后缝合伤口。
2、待手术后一周，将小鼠固定于电刺激固定装置，脊髓硬膜外电刺激电极接头与腿部电刺激电极接头分别连接闭环性电刺激器的脊髓刺激端口和腿部刺激端口。通过控制器(计算机)设置脊髓硬膜外电刺激电极发出的第一电刺激的刺激强度为400-600mV，频率10-20Hz，且设置在第一电刺激发送50ms后腿部电刺激电极发放第二电刺激，第二电刺激的刺激强度为1V，频率10-20Hz，给予小鼠闭环性电刺激训练。每天刺激1小时，每刺激15分钟休息10分钟。
图5是上述电刺激的工作原理图，在闭环性电刺激训中，通过闭环性电刺激器分别给予脊髓硬膜外(S1)及腿部电刺激(S2)，可通过脊髓闭环性电刺激器分别调整S1和S2的刺激强度。刺激训练时将小鼠固定于小鼠固定器，在该装置中小鼠前后肢悬空，可排除四肢带来 的干扰，通过腿部电刺激激活神经环路引导腿部产生自主运动来增强感觉反馈而不是依赖于减重跑步机产生被动运动。脊髓损伤小鼠在10-20Hz闭环性电刺激训练三周后，采用Biopac检测小鼠的肌电信号，生理记录仪所检测的肌电信号传输至计算机，采用计算机中的Matalab软件对其进行数据处理，结果表明，使用本发明的脊髓闭环性电刺激系统所施加的闭环性电刺激促进了脊髓神经环路的重塑。
以上所述仅是本发明的优选实施方式，并不用于限制本发明，应当指出，对于本技术领域的普通技术人员来说，在不脱离本发明技术原理的前提下，还可以做出若干改进和变型，这些改进和变型也应视为本发明的保护范围。

Claims (8)

  1. 一种脊髓闭环性电刺激系统，其特征在于：包括脊髓硬膜外电刺激电极、腿部电刺激电极、闭环性电刺激器和控制器，所述脊髓硬膜外电刺激电极、腿部电刺激电极分别与所述闭环性电刺激器连接，所述控制器与所述闭环性电刺激器电连接，所述脊髓硬膜外电刺激电极用于植入受试者的脊髓硬膜外并向脊髓硬膜外施加第一电刺激，所述腿部电刺激电极用于植入受试者的腿部并向腿部施加第二电刺激，所述控制器用于向所述闭环性电刺激器发送电刺激信号，所述第一电刺激的电压为400-600mV，且频率为10-20Hz，所述第二电刺激的电压为1V-1.5V，且频率为10-20Hz，所述第二电刺激与第一电刺激的电刺激信号发送时间间隔为50ms-60ms。
  2. 根据权利要求1所述的脊髓闭环性电刺激系统，其特征在于：还包括用于固定受试者的电刺激固定装置。
  3. 根据权利要求2所述的脊髓闭环性电刺激系统，其特征在于：所述受试者为小鼠，所述电刺激固定装置包括底座以及设置在所述底座上的小鼠躯干固定单元，所述固定单元包括高度调节组件以及滑动连接在所述高度调节组件上方的固定组件。
  4. 根据权利要求1所述的脊髓闭环性电刺激系统，其特征在于：所述腿部电刺激电极用于植入受试者的腿部胫骨前肌。
  5. 根据权利要求1所述的脊髓闭环性电刺激系统，其特征在于：所述脊髓硬膜外电刺激电极用于植入受试者的L2-L4节脊髓的脊髓硬膜外。
  6. 根据权利要求1所述的脊髓闭环性电刺激系统，其特征在于：所述腿部电刺激电极包括工字型基板、设置在所述工字型基板上的第一触点单元和第一接口单元，所述第一触点单元包括多个电刺激触点和信号接收触点，所述第一接口单元包括正极接口、负极接口和地线接口，其中至少一个所述电刺激触点通过导线电连接所述正极接口、至少一个所述电刺激触点通过导线电连接所述负极接口形成刺激回路；其中至少一个所述信号接收触点通过导线电连接所述正极接口、至少一个所述信号接收触点通过导线电连接负极接口形成反馈回路，其中一个所述信号接收触点通过导线电连接所述地线接口，所述工字型基板上设置有用于覆盖其表面的金箔。
  7. 根据权利要求1所述的脊髓闭环性电刺激系统，其特征在于：所述脊髓硬膜外电刺激电极包括T字型基板，所述T字型基板包括横部和竖部，所述横部上设置有第二接口单元，所述竖部远离所述横部的端部处设置有第二触点单元，所述竖部上还设置有用于将所述T字型基板相对受试者脊椎固定设置的固定单元，所述第二接口单元包括正极接口、负极接口和地线接口，所述第二触点单元包括沿所述竖部延伸方向依次排列的多个刺激触点，其中至少 一个所述刺激触点通过导线连接所述正极接口，至少一个所述刺激触点通过导线连接所述负极接口，形成刺激回路或反馈回路，其中一个所述刺激触点通过导线电连接所述地线接口，所述固定单元包括沿横部延长方向延伸且关于竖部延长方向对称设置的多个固定片，所述固定片上开设有用于将伸入受试者体内的T字型基板相对所述受试者脊椎固定设置的通孔。
  8. 根据权利要求1所述的的脊髓闭环性电刺激系统，其特征在于：所述第一电刺激和第二电刺激施加于受试者时，每天施加电刺激1h，每施加电刺激15min后间隔10min后再进行电刺激。
PCT/CN2020/071041 2019-08-29 2020-01-09 脊髓闭环性电刺激系统 WO2021036165A1 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US17/606,427 US12023493B2 (en) 2019-08-29 2020-01-09 Closed-loop spinal cord electrical stimulation system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910809342.0A CN110404164B (zh) 2019-08-29 2019-08-29 脊髓闭环性电刺激系统
CN201910809342.0 2019-08-29

Publications (1)

Publication Number Publication Date
WO2021036165A1 true WO2021036165A1 (zh) 2021-03-04

Family

ID=68369758

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2020/071041 WO2021036165A1 (zh) 2019-08-29 2020-01-09 脊髓闭环性电刺激系统

Country Status (2)

Country Link
CN (1) CN110404164B (zh)
WO (1) WO2021036165A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110404164B (zh) * 2019-08-29 2020-12-22 苏州大学 脊髓闭环性电刺激系统
CN111408044A (zh) * 2020-03-31 2020-07-14 北京百科康讯科技有限公司 控制器及其语音识别方法和脊髓硬膜外刺激系统
CN116271516B (zh) * 2023-03-29 2023-11-14 中国人民解放军军事科学院军事医学研究院 一种脊髓硬膜外植入多模式贴片电极

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101496748A (zh) * 2008-11-17 2009-08-05 天津大学 功能性电刺激fes助行人工神经假体装置
CN108744270A (zh) * 2017-03-28 2018-11-06 洛桑联邦理工学院 用于中枢神经刺激和外周神经刺激的神经刺激系统
CN208877713U (zh) * 2018-05-28 2019-05-21 苏州大学 一种小鼠硬膜外可插入性针状电极板
CN209137753U (zh) * 2018-01-17 2019-07-23 苏州大学 一种可植入小鼠体内的电极板
CN110404164A (zh) * 2019-08-29 2019-11-05 苏州大学 脊髓闭环性电刺激系统

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9399132B2 (en) * 2009-06-30 2016-07-26 Boston Scientific Neuromodulation Corporation Method and device for acquiring physiological data during tissue stimulation procedure
EP2868343A1 (en) * 2013-10-31 2015-05-06 Ecole Polytechnique Federale De Lausanne (EPFL) EPFL-TTO System to deliver adaptive electrical spinal cord stimulation to facilitate and restore locomotion after a neuromotor impairment
CN104306066B (zh) * 2014-10-22 2016-11-02 南通大学 基于脊髓神经功能电激励的大鼠腿部运动重建实验方法
CN107405249B (zh) * 2015-03-13 2020-09-15 学校法人东海大学 步行训练用脊髓电刺激装置
US10166394B1 (en) * 2015-10-15 2019-01-01 Hrl Laboratories, Llc Device and method to automatically tune the nerve stimulation pattern of a sensory-feedback capable prosthesis
EP3184145B1 (en) * 2015-12-22 2024-03-20 Ecole Polytechnique Fédérale de Lausanne (EPFL) System for selective spatiotemporal stimulation of the spinal cord
WO2018033591A2 (en) * 2016-08-17 2018-02-22 Ecole Polytechnique Federale De Lausanne (Epfl) Apparatus comprising a support system for a user and its operation in a gravity-assist mode
CN106345055A (zh) * 2016-09-19 2017-01-25 天津大学 一种基于步态识别的功能性肌肉电刺激助行装置
EP3535021B1 (en) * 2016-11-04 2022-06-22 Restorative Therapies Functional electrical stimulation ergometer including automatic spasm control
CN110121375B (zh) * 2016-12-23 2024-02-02 洛桑联邦理工学院 用于运动功能恢复的感觉信息顺应性脊髓刺激系统
CN207721918U (zh) * 2017-05-23 2018-08-14 苏州大学 小鼠电刺激简易固定装置
EP3974021B1 (en) * 2017-06-30 2023-06-14 ONWARD Medical N.V. A system for neuromodulation
CN109999341A (zh) * 2018-01-04 2019-07-12 精能医学股份有限公司 电刺激器、制造电刺激器的方法及电刺激系统
CN108261607B (zh) * 2018-03-20 2021-06-01 北京理工大学 一种用于运动机能调控的功能性经皮神经电刺激装置
CN108939291A (zh) * 2018-06-25 2018-12-07 中国医学科学院医学实验动物研究所 一种改善帕金森运动障碍的神经刺激方法
CN108926407A (zh) * 2018-08-06 2018-12-04 南通大学 一种实验性下肢节律运动大鼠模型的建立方法及其应用
CN109124807A (zh) * 2018-11-27 2019-01-04 南通大学 一种基于时间相干刺激的大鼠脊髓运动功能重建方法
CN110075420A (zh) * 2019-04-26 2019-08-02 南通大学 一种脊髓功能电刺激信号对下肢步态调控作用的研究方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101496748A (zh) * 2008-11-17 2009-08-05 天津大学 功能性电刺激fes助行人工神经假体装置
CN108744270A (zh) * 2017-03-28 2018-11-06 洛桑联邦理工学院 用于中枢神经刺激和外周神经刺激的神经刺激系统
CN209137753U (zh) * 2018-01-17 2019-07-23 苏州大学 一种可植入小鼠体内的电极板
CN208877713U (zh) * 2018-05-28 2019-05-21 苏州大学 一种小鼠硬膜外可插入性针状电极板
CN110404164A (zh) * 2019-08-29 2019-11-05 苏州大学 脊髓闭环性电刺激系统

Also Published As

Publication number Publication date
US20220212003A1 (en) 2022-07-07
CN110404164B (zh) 2020-12-22
CN110404164A (zh) 2019-11-05

Similar Documents

Publication Publication Date Title
WO2021036165A1 (zh) 脊髓闭环性电刺激系统
US9821157B2 (en) Charge-enhanced neural electric stimulation system
EP3434323B1 (de) Vorrichtung zur funktionalen elektrischen stimulation unter wasser
Sheffler et al. Neuromuscular electrical stimulation in neurorehabilitation
KR101866252B1 (ko) 차지 강화된 신경의 전기적 자극 시스템
JP2004524125A (ja) 両側声帯自律麻痺のためのペースメーカー
US20040073271A1 (en) Method and apparatus for neurophysiologic performance
JP2018164730A (ja) 中枢神経刺激（ｃｎｓ）および末梢神経刺激（ｐｎｓ）のための神経刺激システム
US11672982B2 (en) Control system for movement reconstruction and/or restoration for a patient
JP2001518828A (ja) 音声駆動運動装置と使用方法
Bhatia et al. State of art: functional electrical stimulation (FES)
US20060047326A1 (en) Application of specific neuromodulation waveforms to reduce symptoms of neurological disorders
Stevenson et al. Interlimb communication to the knee flexors during walking in humans
Uhlir et al. Performance of epimysial stimulating electrodes in the lower extremities of individuals with spinal cord injury
McNeal et al. Control of skeletal muscle by electrical stimulation
Gorman An update on functional electrical stimulation after spinal cord injury
Kim et al. Adaptive control of movement for neuromuscular stimulation-assisted therapy in a rodent model
McCabe et al. Feasibility of combining gait robot and multichannel functional electrical stimulation with intramuscular electrodes.
US12023493B2 (en) Closed-loop spinal cord electrical stimulation system
Davis et al. Computer-controlled 22-channel stimulator for limb movement
US11383081B2 (en) Neurostimulation system and method for modulating abnormal motor movement
US9108054B2 (en) Method for modifying larynx position by trans-positioning muscle and electrode stimulation
WO2016108332A1 (ko) 능동형 생체이식 경천추 경막외 척수신경 자극을 위한 카테터용 박동성 고주파 자극장치
Azman et al. The design of non-invasive functional electrical stimulation (FES) for restoration of muscle function
EP2550060B1 (en) Charge-enhanced neural electric stimulation system

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20856409

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20856409

Country of ref document: EP

Kind code of ref document: A1