WO2021029991A1 - Appareil, systèmes et procédés de collecte de particules magnétiques - Google Patents
Appareil, systèmes et procédés de collecte de particules magnétiques Download PDFInfo
- Publication number
- WO2021029991A1 WO2021029991A1 PCT/US2020/041358 US2020041358W WO2021029991A1 WO 2021029991 A1 WO2021029991 A1 WO 2021029991A1 US 2020041358 W US2020041358 W US 2020041358W WO 2021029991 A1 WO2021029991 A1 WO 2021029991A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- guide
- particle collection
- magnet
- magnetic
- magnetic particle
- Prior art date
Links
- 239000006249 magnetic particle Substances 0.000 title claims abstract description 141
- 238000000034 method Methods 0.000 title claims abstract description 30
- 239000007788 liquid Substances 0.000 claims description 21
- 238000006243 chemical reaction Methods 0.000 claims description 18
- 239000003153 chemical reaction reagent Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 11
- 238000004804 winding Methods 0.000 claims description 4
- 230000008878 coupling Effects 0.000 claims description 3
- 238000010168 coupling process Methods 0.000 claims description 3
- 238000005859 coupling reaction Methods 0.000 claims description 3
- 230000009089 cytolysis Effects 0.000 claims description 3
- 238000010828 elution Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 4
- 238000003756 stirring Methods 0.000 description 4
- 230000005484 gravity Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000005406 washing Methods 0.000 description 3
- 229910052779 Neodymium Inorganic materials 0.000 description 2
- 230000000712 assembly Effects 0.000 description 2
- 238000000429 assembly Methods 0.000 description 2
- QEFYFXOXNSNQGX-UHFFFAOYSA-N neodymium atom Chemical compound [Nd] QEFYFXOXNSNQGX-UHFFFAOYSA-N 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000012491 analyte Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000012863 analytical testing Methods 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 239000012149 elution buffer Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 230000002934 lysing effect Effects 0.000 description 1
- 239000002991 molded plastic Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/025—High gradient magnetic separators
- B03C1/031—Component parts; Auxiliary operations
- B03C1/033—Component parts; Auxiliary operations characterised by the magnetic circuit
- B03C1/0332—Component parts; Auxiliary operations characterised by the magnetic circuit using permanent magnets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/284—Magnetic plugs and dipsticks with associated cleaning means, e.g. retractable non-magnetic sleeve
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/286—Magnetic plugs and dipsticks disposed at the inner circumference of a recipient, e.g. magnetic drain bolt
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/30—Combinations with other devices, not otherwise provided for
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/18—Magnetic separation whereby the particles are suspended in a liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/28—Parts being designed to be removed for cleaning purposes
Definitions
- FIG. 3C illustrates a cross-sectioned side view of a portion of a magnetic particle collection device including a magnet in an extended position shown removing magnetic particles from a well of a multi-well pack according to embodiments of the disclosure.
- FIG. 4 illustrates a flowchart of a method of magnetic particle collection according to embodiments.
- the individual magnets 230 may be neodymium cylindrical magnets that are magnetized through their lengths (e.g., length L21), with north pole on one end and the south pole on the other.
- the individual magnet 230A may have a diameter D21 of about 0.138" (3.50 mm) and a thickness or length L21 of about 0.157"
- the magnet 104 may be referred to as being in the retracted position, or the second position, where the magnetic pickup end 104A is spaced from the first terminal end 114A.
Landscapes
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
L'invention concerne un appareil de collecte de particules magnétiques comprenant une bobine, un guide s'étendant à partir de la bobine, le guide comprenant une première extrémité terminale, un aimant reçu de manière coulissante dans le guide, l'aimant comprenant une extrémité de capture magnétique, l'excitation de la bobine générant un champ magnétique qui agit sur l'aimant et déplace l'extrémité de capture magnétique entre une première position au niveau de la première extrémité terminale et une seconde position éloignée de la première extrémité terminale. L'invention concerne également des systèmes et des procédés de collecte de particules magnétiques.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962887175P | 2019-08-15 | 2019-08-15 | |
| US62/887,175 | 2019-08-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2021029991A1 true WO2021029991A1 (fr) | 2021-02-18 |
Family
ID=74570712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2020/041358 WO2021029991A1 (fr) | 2019-08-15 | 2020-07-09 | Appareil, systèmes et procédés de collecte de particules magnétiques |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2021029991A1 (fr) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6409925B1 (en) * | 1998-02-06 | 2002-06-25 | Bio-Magnetics Ltd. | Device and system for transfer of material |
| US20060118494A1 (en) * | 2002-10-18 | 2006-06-08 | Kenneth Rundt | Magnetic transfer method, a device for transferring microparticles and a reactor unit |
| US20060266130A1 (en) * | 2005-05-24 | 2006-11-30 | Festo Corporation | Apparatus and method for transferring samples from a source to a target |
| US20110205835A1 (en) * | 2007-08-14 | 2011-08-25 | Qiagen Gmbh | Method for suspending or re-suspending particles in a solution and apparatus adapted thereto |
| US20130001242A1 (en) * | 2010-01-05 | 2013-01-03 | Hamilton Bonaduz Ag | Metering device and metering method |
| WO2018060137A1 (fr) * | 2016-09-30 | 2018-04-05 | Hamilton Bonaduz Ag | Dispositif de séparation magnétique à accouplement immatériel entre un ensemble magnétique et son entrainement de déplacement |
-
2020
- 2020-07-09 WO PCT/US2020/041358 patent/WO2021029991A1/fr active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6409925B1 (en) * | 1998-02-06 | 2002-06-25 | Bio-Magnetics Ltd. | Device and system for transfer of material |
| US20060118494A1 (en) * | 2002-10-18 | 2006-06-08 | Kenneth Rundt | Magnetic transfer method, a device for transferring microparticles and a reactor unit |
| US20060266130A1 (en) * | 2005-05-24 | 2006-11-30 | Festo Corporation | Apparatus and method for transferring samples from a source to a target |
| US20110205835A1 (en) * | 2007-08-14 | 2011-08-25 | Qiagen Gmbh | Method for suspending or re-suspending particles in a solution and apparatus adapted thereto |
| US20130001242A1 (en) * | 2010-01-05 | 2013-01-03 | Hamilton Bonaduz Ag | Metering device and metering method |
| WO2018060137A1 (fr) * | 2016-09-30 | 2018-04-05 | Hamilton Bonaduz Ag | Dispositif de séparation magnétique à accouplement immatériel entre un ensemble magnétique et son entrainement de déplacement |
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