WO2021020759A1 - Dispositif de retenue pour injection ou prélèvement sanguin de veine caudale chez un petit animal - Google Patents

Dispositif de retenue pour injection ou prélèvement sanguin de veine caudale chez un petit animal Download PDF

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Publication number
WO2021020759A1
WO2021020759A1 PCT/KR2020/008909 KR2020008909W WO2021020759A1 WO 2021020759 A1 WO2021020759 A1 WO 2021020759A1 KR 2020008909 W KR2020008909 W KR 2020008909W WO 2021020759 A1 WO2021020759 A1 WO 2021020759A1
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WO
WIPO (PCT)
Prior art keywords
tail
control unit
position control
blood collection
experimental animal
Prior art date
Application number
PCT/KR2020/008909
Other languages
English (en)
Korean (ko)
Inventor
박성걸
남유리
박소라
임창묵
Original Assignee
박성걸
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 박성걸 filed Critical 박성걸
Publication of WO2021020759A1 publication Critical patent/WO2021020759A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D3/00—Appliances for supporting or fettering animals for operative purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/15003—Source of blood for venous or arterial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150053—Details for enhanced collection of blood or interstitial fluid at the sample site, e.g. by applying compression, heat, vibration, ultrasound, suction or vacuum to tissue; for reduction of pain or discomfort; Skin piercing elements, e.g. blades, needles, lancets or canulas, with adjustable piercing speed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D1/00—Surgical instruments for veterinary use
    • A61D1/02—Trocars or cannulas for teats; Vaccination appliances
    • A61D1/025—Vaccination appliances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3287—Accessories for bringing the needle into the body; Automatic needle insertion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/42—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for desensitising skin, for protruding skin to facilitate piercing, or for locating point where body is to be pierced
    • A61M5/427—Locating point where body is to be pierced, e.g. vein location means using ultrasonic waves, injection site templates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals

Definitions

  • the present invention relates to a small-animal microvenous administration or blood collection correction device that assists the blood collection from the tail portion after fixing an experimental animal used for various experiments, particularly an experimental rat, and fixing the body of the experimental animal, and It relates to a small animal coarse vein administration or blood collection correction device that can be used for selectively inserting and collecting blood into a vein or artery located at.
  • intravenous injection has many advantages over other routes. Since the drug reaches the necessary tissues of the body through the heart within a few seconds, the medicinal effect appears quickly, and the reaction also appears clearly. It is used to supply water, salt, and other necessary electrolytes when it is not possible to administer enough water orally, or when injecting drugs such as antidote into the blood or expecting rapid efficacy, including blood supply after bleeding.
  • experimental rats are used in a relatively large number.
  • intravenous injection is essentially used, and usually, the rat is held with one hand and the tail is injected with the other hand.
  • the experimental rats have thin and weak blood vessels and require technical skill due to the fluctuation of the tail and it is difficult for one person to inject.
  • an auxiliary device was devised to fix the body of an experimental rat inside the barrel, but there was a limitation in use by placing the body inside the barrel so that only the tail vein was secured rather than conveniently and stably fixing the laboratory rat. .
  • the present invention has been conceived to solve the above problems, stably and quickly fixing the body of a rat for experimentation, and limiting the movement of the tail by removing only the tail separately, so that precise injection can be performed by intravenous administration or blood collection of small animals It is an object of the present invention to provide a correction device.
  • the present invention is a mounting plate 100 on which an experimental animal with a tail is placed; A fixing part 200 coupled with the seating plate 100 to restrain the experimental animal placed on the seating plate 100; A position control unit 300 coupled to one side of the mounting plate 100 to support the mounting plate 100; And at least one guide plate 400 coupled to the upper surface of the position control unit 300 and configured to be constrained by the experimenter determining the bending direction of the tail.
  • the seating plate 100 of the present invention may be coupled to be rotatable about a rotation shaft 110 coupled to the position control unit 300.
  • the seating plate 100 of the present invention further includes a rotation lever 120 provided with a tail insertion hole 121 through which the tail of the experimental animal is inserted and fixed, and the tail is rotated by the rotation of the rotation lever 120. It can be rotated a predetermined angle.
  • the position control unit 300 of the present invention may be hinge-coupled with a support arm 600 fixed to one side of the position control unit 300 so as to rotate by a predetermined angle with respect to the ground.
  • the guide plate 400 of the present invention includes a first guide plate 410 fixed to an upper surface of one side of the position control unit 300 and a first guide groove 440 in which the tail is disposed.
  • a second guide plate 420 may be spaced apart from the plate 410 and fixed to the upper surface of the other side of the position control unit 300.
  • the first or second guide plate 410 in order to provide a second guide groove 450 for changing the direction of the tail, at the lower side of the first or second guide plate 410, 420 of the present invention. It may include a third guide plate 430 that is spaced apart from the 420 by a predetermined distance and fixed to the upper surface of the other side of the position control unit 300.
  • the fixing part 200 of the present invention includes a jacket 210 coated on the body of the experimental animal and a boa system 220 for intimate contact with the seating plate 100, or the fixing part 200 is coupled to the mounting plate 100, may be a mold 230 for pressing the body of the experimental animal.
  • the present invention constrains the movement of the body of the test subject and minimizes the movement of the tail, so that when the drug is injected into the tail, the injection can be accurately performed, and the angle and height formed by the test subject and the tail can be adjusted. .
  • the present invention can easily find and inject a vein or arterial blood vessel in the tail portion due to the configuration of the specimen seating plate and the guide plate that can rotate at a certain angle.
  • FIG. 1 is a conceptual diagram illustrating a coarse vein blood collection system including an experimental animal correction device according to the present invention.
  • Figure 2 is a conceptual diagram showing an embodiment related to the guide plate of the experimental animal correction apparatus according to the present invention.
  • FIG. 3 is a conceptual diagram showing another embodiment related to a guide plate among the experimental animal correction apparatus according to the present invention.
  • Figure 4 is a plan view showing another embodiment related to the guide plate of the experimental animal correction apparatus according to the present invention.
  • Figure 5 is a conceptual diagram related to the rotation lever of the experimental animal correction device according to the present invention.
  • FIG. 1 is an overall conceptual diagram of a coarse vein blood collection or administration system.
  • An experimental animal correction apparatus according to the present invention is shown in order to collect a blood sample from an experimental animal fixed to the experimental animal correction apparatus according to the present invention, in particular, of a rat.
  • the near-infrared rays are irradiated on the upper side of the caudal vein of the experimental animal fixed to the experimental animal correction device, and the position on the caudal vein is accurately determined using an optical microscope. Magnification using a digital camera connected to an optical microscope, and the experimenter can visually check it through a digital viewer.
  • Thermal action and angiography are possible using a near-infrared irradiation device, and using an optical microscope to magnify the caudal vein of the mouse 10 to 100 times and check the position of the needle with a digital viewer (LCD screen), Administration or blood collection can be performed.
  • a near-infrared irradiation device and using an optical microscope to magnify the caudal vein of the mouse 10 to 100 times and check the position of the needle with a digital viewer (LCD screen), Administration or blood collection can be performed.
  • the present invention includes a seating plate 100, a fixing part 200, a position control part 300, a guide plate 400, a heating part 500, and the like.
  • a support arm 600 and a base 700 for supporting and fixing them may be further included.
  • the base 700 is used for support by being placed on the ground or an experimental table.
  • a support arm 600 for fixing the position control unit 300 or the like, which will be described later, is fixed on the upper part of the base 700.
  • the support arm 600 may be fixed in a state inclined at a predetermined angle with respect to the base 700 in consideration of the user's usability.
  • the slope can be arbitrarily designed in consideration of the experimenter's convenience.
  • a position control unit 300 and the like are provided above the support arm 600.
  • the position control unit 300 serves as a base to which an experimental animal placed on a mounting plate 100 to be described later is fixed.
  • the position control unit 300 may be hinged (not shown) with the support arm 600 described above to be tilted at a predetermined angle. That is, while adjusting the inclination of the position control unit 300 according to the propensity of the experimenter, the position of the caudal vein is identified or the experiment is made easy.
  • the hinge coupling since various known techniques may be applied, specific details are avoided.
  • the guide plate 400 is disposed on the upper surface of the position control unit 300 described above.
  • a plurality of regularly or irregularly holes or protrusions 310 may be arranged on the upper surface of the position control unit 300 as shown.
  • the guide plate 400 may also have a protrusion or a hole 470 at a position corresponding thereto.
  • a magnet may be provided in all or one of them so that the guide plate 400 and the position control unit 300 may be coupled with a magnet or the like.
  • the above-described holes or protrusions 310 and 470 may facilitate coupling between the guide plate 400 and the position control unit 300 and serve as a guide for the experimenter to determine the position for various purposes such as experiments.
  • the guide plate 400 includes first to third guide plates 410, 420, and 430.
  • the first and second guide grooves 440 and 450 may be naturally formed by being coupled to the upper surface of the position control unit 300 by the guide plate 400 made of at least three or more plates.
  • the tail of the experimental animal is inserted and fixed inside the first and second guide grooves 440 and 450.
  • the first guide plate 410 may be fixedly coupled to one half-divided surface of the position control unit 300.
  • a second guide plate 420 is attached to the upper divided surface and a third guide plate 430 is fixed to the position control unit 300 on the lower divided surface.
  • the first and second guide grooves 440 and 450 as described above may be formed between them (see FIGS. 1 and 2 ).
  • the second guide groove 450 may be cut so that the ends of the second and third guide plates 420 and 430 have a'base (a)' shape.
  • the second guide groove 450 is naturally formed by the coupling of the second and third guide plates 420 and 430.
  • the tail of the experimental animal may be seated and fixed in the second guide groove 450.
  • the experimenter may arbitrarily change the positions of the first to third guide plates 410, 420, and 430 for convenience of experimentation.
  • the second and third guide plates 420 and 430 may be manufactured symmetrically. For this reason, even if the second and third guide plates 420 and 430 are flipped in place or moved left and right, it is preferable to be fastened to the position control unit 300 in the same shape or to perform the same function.
  • a pair of guide rollers 460 may be disposed at a portion bent from the first guide groove 440 to the second guide groove 450 so that the tail of the experimental animal can be firmly fixed.
  • the guide roller 460 may include a core 461 around the shaft 462 and a louver 461 surrounding the core 461.
  • the louver 461 is a part to which the tail of the experimental animal comes into contact, and may be formed of a material that does not slip, for example, rubber.
  • Figs. 1 to 4 it is preferable to fix the tail in a curved state of approximately 90 degrees in order to improve the accuracy of experiments such as accurate microvein check and blood collection by utilizing the above-described configuration.
  • the position control unit 300, the guide plates 400, 410, 420, 430, and the like are heated.
  • a heating unit 500 is provided between the position control unit 300 and the guide plates 400, 410, 420, and 430.
  • the heating unit 500 may be provided on the inner side of the position control unit 300. That is, since the heating unit 500 has the purpose of raising the temperature of the tail of the experimental animal, any location for raising the temperature may be used.
  • the seating plate 100 is fixed to one side of the position control unit 300 so as to be rotatable.
  • the rotation shaft 110 is fixed to one side of the position control unit 300.
  • the experimental animal is rotated by rotating the mounting plate 100 on which the body of the experimental animal is fixed. According to the rotation of the experimental animal, the position of the caudal vein or the caudal artery can be accurately varied.
  • a rotation lever 120 is provided on one side of the seating plate 100. It is preferable to configure the rotation lever 120 to be able to rotate alone or to rotate integrally with the seating plate 100. It is preferable that the rotation shaft 110 is provided at an approximately central portion of the rotation lever 110 and the tail insertion hole 121 is provided at an upper central side.
  • the tail insertion hole 121 may be formed in a circular or semicircular shape. When only the rotation lever 120 is independently rotated, it is desirable to form a semicircular shape rather than a circular shape. That is, since only the tail can be twisted (rotated) when the rotation lever 120 is independently rotated, the position of the caudal vein or the caudal artery can be controlled.
  • the position control unit 300 is provided with a stopper unit 310, it is possible to restrict the rotation degree of the rotation lever 120.
  • the fixing part 200 may be composed of a jacket 210 and a bore system 220, or may be composed of a mold 230, as shown in FIGS. 1 and 2.
  • the experimental animal can be constrained to the seating plate 100 by using the boa system 220.
  • the boA system 220 is a fastening type mainly used for shoes, in which the strap is tightened according to the rotation of the fixed dial using a fixed dial and a strap, and a detailed description thereof will be omitted.
  • a string or the like is fastened together with the jacket 210, and a part of the string is constrained by the seating plate 100 so that the experimental animal may be constrained while wearing the jacket 210.
  • the mold 230 may be fastened to the seating plate 100 while pressing the back of the experimental animal.
  • the mold 230 may be made of a frame formed of one mold, and it is preferable that the mold 230 and the fixing part 200 are easily fastened and fixed using a magnet or the like.
  • the tail can be easily fixed separately for collecting blood vessels or injecting drugs into the caudal vein or the caudal artery.
  • the experimental animal can be fixed very quickly and accurately, but also the tail can be easily fixed in a curved state of about 90 degrees, which will improve the repeatability and accuracy of the experimenter's experiment. .

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Zoology (AREA)
  • Vascular Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Anesthesiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Husbandry (AREA)
  • Pain & Pain Management (AREA)
  • Housing For Livestock And Birds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

La présente invention concerne un dispositif de retenue pour l'injection ou le prélèvement sanguin de veine caudale chez un petit animal, qui fixe un animal de laboratoire utilisé pour diverses expériences, en particulier un rat de laboratoire, et facilite ensuite le prélèvement sanguin à partir d'une partie caudale de celui-ci. Au moyen du dispositif de retenue, une fois qu'un animal de laboratoire est disposé sur une plaque de siège stable (100), une partie caudale de l'animal de laboratoire peut être maintenue facilement et séparément pour la collecte de vaisseau sanguin ou l'injection de médicament dans une veine caudale ou une artère caudale associée, etc. En particulier, au moyen du dispositif de retenue, un animal de laboratoire peut être maintenu très rapidement et avec précision, et également une partie caudale de celui-ci peut être facilement maintenue dans un état dans lequel la partie caudale est pliée à environ 90 degrés. Par conséquent, le dispositif de retenue peut améliorer la reproductibilité et la précision à répétition au moment d'une expérience de l'expérimentateur.
PCT/KR2020/008909 2019-07-30 2020-07-08 Dispositif de retenue pour injection ou prélèvement sanguin de veine caudale chez un petit animal WO2021020759A1 (fr)

Applications Claiming Priority (2)

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KR1020190092256A KR102038991B1 (ko) 2019-07-30 2019-07-30 소동물 미정맥 투여 또는 채혈 보정장치
KR10-2019-0092256 2019-07-30

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KR102404139B1 (ko) * 2020-03-19 2022-06-02 주식회사 바이탈스 혈액 채취가 가능한 마우스 홀더 장치
CN111616825B (zh) * 2020-05-15 2021-07-20 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 用于固定大鼠睾丸进行注射的固定装置
KR102533678B1 (ko) * 2021-08-25 2023-05-17 (주)플라스바이오 다양한 약물 투여 방법에 적용 가능한 실험동물 보정기
US20230062009A1 (en) * 2021-08-25 2023-03-02 PLASBIO Co.,Ltd Experimental animal restrainer applicable to various drug administration method
KR102410632B1 (ko) * 2021-11-08 2022-06-22 (주)플라스바이오 동물실험용 물질 자동 주입 시스템
WO2023082030A1 (fr) * 2021-11-15 2023-05-19 吴琪 Appareil expérimental d'aide à l'injection dans la veine de queue de souris

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US6789510B1 (en) * 2003-05-30 2004-09-14 Ru-Ping Lee Animal restraining apparatus and animal experiment for using the same
JP2013503641A (ja) * 2009-09-02 2013-02-04 ソマーク イノベイションズ， インコーポレイテッド 動物の標識デバイス、転写アセンブリおよび有用な拘束具
JP2013244095A (ja) * 2012-05-24 2013-12-09 Asti Corp 生体穿刺補助装置と生体穿刺装置
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KR20170121978A (ko) * 2016-04-26 2017-11-03 주식회사 씨원라이프테크 소동물 수술 시스템

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KR101280350B1 (ko) * 2011-04-27 2013-07-01 조순복 수의용 소동물 받침대
KR101633560B1 (ko) 2014-10-08 2016-06-27 울산대학교 산학협력단 실험용 쥐의 미정맥 주사 및 채혈 보조기구
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Publication number Priority date Publication date Assignee Title
US6789510B1 (en) * 2003-05-30 2004-09-14 Ru-Ping Lee Animal restraining apparatus and animal experiment for using the same
JP2013503641A (ja) * 2009-09-02 2013-02-04 ソマーク イノベイションズ， インコーポレイテッド 動物の標識デバイス、転写アセンブリおよび有用な拘束具
JP2013244095A (ja) * 2012-05-24 2013-12-09 Asti Corp 生体穿刺補助装置と生体穿刺装置
KR20140109116A (ko) * 2013-03-05 2014-09-15 경상대학교산학협력단 동물용 수술대
KR20170121978A (ko) * 2016-04-26 2017-11-03 주식회사 씨원라이프테크 소동물 수술 시스템

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