WO2021019412A1 - Composition of chlorantraniliprole, picoxystrobin and propiconazole - Google Patents

Abstract

The present invention discloses a synergistic combination of chlorantraniliprole, picoxystrobin and propiconazole with its compositionand a method for controllinga wide variety of undesired pathogenic microorganisms, insect pests and mites, for plants, including the treatment of plant/plant parts and a region around the plant.The present invention also discloses an enhanced efficacy against pests and diseases in comparison to the individual components of the said combination.The combination also widens the spectrum and said to have longer residual effect against undesired pathogenic microorganisms, insect pests and mites. The combination is also able to increaseplant health.

Description

TITLE OF THE INVENTION: COMPOSITION OF CHLORANTRANILIPROLE, PICOXYSTROBIN AND PROPICONAZOLE

FIELD OF THE INVENTION:

The present invention relates to a combination of chlorantraniliprole, picoxystrobin and propiconazole and its composition. Particularly, the present invention relates to acomposition comprising of chlorantraniliprole, picoxystrobin and propiconazole, methods of preparation of said composition and use thereof for the control of a wide variety of undesired phytopathogenic microorganisms, insect pests and mites.

BACKGROUND OF THE INVENTION:

In many economically important crops, such as rice, peppers, tomatoes, grapes, peas, cotton and other agricultural and horticultural crops, fungal infection and insect infestation may occur simultaneously, for which growers are applying control measures either separatelyorby simply tank mixing various insecticides and fungicides together. This practice of mixing various pesticides might lead to poor efficacy and crop damage due to compatibility issues.Hence, a premix of the best possible formulation for a combination of an insecticide and a fungicide would help growers to combat these important diseases and insects/mites in those crop stages.

Typical problems arising in the field of pest control are to reduce the dose rates of the active ingredients in order to reduce or avoid unfavorable environmental or toxicological effects whilst still allowing effective disease/pest control. Therefore, a combined application of an effective amount of fungicide and insecticide as a uniform composition is a practical necessity.

Chlorantraniliprole is an insecticidal compound, which belongs to anthranilic diamide chemical class. It was developed by FMC Corporation, as described in U.S. 7,232,836. It is used to control or suppress a wide range of insect pests and diseases, including Lepidoptera, Coleoptera, Diptera, and Isoptera insects.lt is effective in controlling all developmental stages of most target pests. It is classified under group 28 of the IRAC mode of action.Chlorantraniliprole is a ryanodine receptor modulator that modulates intracellular Ca⁺² releases.

Chemically, it is 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-l-(3-chloro-2- pyridinyl)-lH-pyrazole-5-carboxamide and has the following structure:

Strobilurin derivatives for example, picoxystrobin, pyraclostrobin, azoxystrobin, fluoxastrobin, trifloxystrobin,pyribencarb, or pyraoxystrobin have fungicidal activity. Picoxystrobin is a broad spectrumfungicide, developed by Zeneca Ltd, as described in U.S. 5,438,059. It is classified under group 11 of the FRAC mode of action, which blocks the mitochondrial electron transport and thus inhibits the energy supply of the fungus which results in the death of the target fungus. Currently, it is used to controlvarious fungal diseases, including rusts, moulds and mildews.

Chemically, it is methyl-(2£)-3-methoxy-2-{2-[6-(trifluoromethyl)-2- pyridyloxymethyl]phenyl}acrylateand has the following structure:

Propiconazole is a broad spectrum systemic fungicidal compound, which belongs to thechemical class of triazoles. It was developed by JanssenPharmaceutica, as described in U.S. 4,079,062. It is classified under group 3 of the FRAC mode of action, which acts as demethylation inhibitor due to its binding with and inhibiting the 14-alpha demethylase enzyme from demethylating a precursor to ergosterol. Currently, it is used against the disease caused by:

Blumeria (formerly Erysiphe ) graminis (powdery mildew); Sclerotinia homoeocarpa (Dollar spot), Colletotrichum graminicola, Rhizoctonia solani, powdery mildew, Puccinia spp. e.g. Puccinia graminis, Laetisaria fuciformis (Red thread); Limonomyces roseipellis (Pink Patch; Ustilago striiformis (Stripe smut); Ustilago agropyn; Pyriculariagrisea Bipolaris and Drechslera spp. P. oryzae (teleomorph: Magnaporthe grise); Magnaporthe poae on Kentucky bluegrass Gaeuman nomycesgraminis (take-all patch); Leptosphaeria korrae and Leptosphaeria namarv, Ophiosphaerella herpotricha Pseudocercosporella herpotrichoides (eyespot, teleomorph: Tapesia yallundae); Pyrenophora teres, Rhynchosporium secalis, Septoria spp.; S. nodorum (Stagonospora blotch, teleomorph: Leptosphaeria (syn. Phaeosphaeria ) nodorum ); Microdochium (syn. Fusarium ) nivale (pink snow mold); R. cerealis (Rhizoctonia spring blight); R. solani (sheath blight). It controls mildews, rusts, leafspots, scabs, and blights. It also exhibits strong anti-feeding properties against the keratin-digesting Australian carpet beetle ( Anthrenocerus australis ).

Chemically, it is l-[[2-(2,4-dichlorophenyl)-4-propyl-l,3-dioxolan-2-yl]methyl]-lH-l, 2, 4-triazole has the following structure:

Various patent applications disclose the mixtures of fungicides and insecticides for e.g. US20120322654, US20080261811, US2008026044, EP2489266, and WO2011144593.There is no such effective composition available that act simultaneously on a wide variety of fungi and pest.

It has been found that, as a solution to the above mentioned problems, a combination comprising of chlorantraniliprole, picoxystrobin and propiconazole provides an effective composition in controlling a wide variety of undesired phytopathogenic microorganisms, insect pests and mites.

SUMMARY OF THE INVENTION:

In one aspect, the present invention provides asynergistic combination of chlorantraniliprole, picoxystrobin and propiconazole, wherein optionally, an addition of one or more insecticidal or fungicidal or acaricidal or nematicidal or herbicidal compounds or any combination thereof is possible.

In one aspect, the present invention provides a synergistic combination of chlorantraniliprole, picoxystrobin and propiconazole to control a wide variety of undesired phytopathogenic microorganisms, insect pests and mites.

In another aspect, the present invention provides a synergistic fungicidal and insecticidal combination of chlorantraniliprole, picoxystrobin and propiconazole. In another embodiment, the present invention providesa longer residual control of the undesired phytopathogenic microorganisms, insect pests and mites treated with the combination of chlorantraniliprole, picoxystrobin and propiconazole.

In one aspect, the present invention provides a synergistic composition of chlorantraniliprole, picoxystrobin and propiconazole to control a wide variety of undesired phytopathogenic microorganisms, insect pests and mites.

In anaspect, the present invention provides a synergistic composition comprising of chlorantraniliprole, picoxystrobin and propiconazole; thecomposition possesses fungicidal and/or insecticidal activity.

In another aspect, the present invention provides a method for the preparation of the composition comprising chlorantraniliprole, picoxystrobin and propiconazole.

In another aspect, the present invention provides a synergistic composition of chlorantraniliprole, picoxystrobin and propiconazole, wherein the composition is used as fungicidal and/or insecticidal composition. The composition is selected from suspension concentrate (SC), wettable granules (WG), wettable powder (WP), a water dispersible granule (WDG), a water dispersible tablet (WT), an ultra- low volume (ULV) liquid (UL), an ultra-low volume (ULV) suspension (SU), a water soluble powder (SP), a suspo-emulsion (SE), granule (GR), an emulsifiable granule (EG), an oil-in-water emulsion (EW), an emulsifiable concentrate (EC), a micro-emulsion (ME), an oil dispersion (OD), a capsule suspension (CS), a dustable powder (DP) or an aerosol (AE).

In another aspect, the present invention provides a composition of chlorantraniliprole, picoxystrobin and propiconazole, wherein active ingredeients chlorantraniliprole, picoxystrobin and propiconazole having a particle size of 5 to 60 pm, more preferably 5 to 30 pm, most preferably 5 to 10 pm.

In another aspect, the present invention provides a composition of chlorantraniliprole, picoxystrobin and propiconazole, wherein active ingredeients having a particle size (d50, determined after dispersion in the water phase by laser diffraction) of 5 to 40 pm, more preferably 5 to 30 pm, most preferably 5 to 10 pm.

In another aspect, the present invention provides a method for improving crop health (phyto-tonic effect), comprising treating a plant with an effective amount of composition of chlorantraniliprole, picoxystrobin and propiconazole. The above aspectsand other objectives will become more apparent in view of the description given below.

DETAILED DESCRIPTION OF THE INVENTION:

ABBREVIATIONS

DEFINITIONS

The foregoing definitions provided herein for the terminologies used in the present disclosure are for illustrative purpose only and in no manner limit, the scope of the present invention disclosed in the present disclosure.

It will be understood that the terminology used herein is for the purpose of describing embodiments only, and is not intended to be limiting. As used in this specification, the singular forms "a", "an" and "the" include plural referents unless the context clearly dictates otherwise. Thus, for example, the reference to "a surfactant" includes one or more of such surfactants.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one ordinary skilled in the art to which the invention pertains. Although other methods and materials similar, or equivalent, to those described herein can be used in the practice of the present invention, the preferred materials and methods are described herein.

As used herein, the terms "comprises", "comprising", "includes", "including", or any other variation thereof, are intended to cover a non-exclusive inclusion, subject to any limitation explicitly indicated. For example, a composition or a method that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, or method.

As used herein, the term“composition” or "formulation" can be used interchangeably, unless stated otherwise, is meant to encompass, and are not limited to, compositions or formulations containing the combination of chlorantraniliprole, picoxystrobin and propiconazole.

As used herein, the term “additive(s)” or "auxiliary agent(s)" or “agriculturally acceptable carrier(s)”can be used interchangeably and refers to inert substances which are commonly used as diluent, to provide stability or to increase the activity profile of the composition or formulation with or without having agrochemical activity or direct effect on the undesired pathogenic microorganism, insect pests and mites.

As used herein, the term“surfactant(s)” means a compound that, when dissolved in a liquid, reduces the surface tension of the liquid, which reduces the interfacial tension between two liquids or which reduces surface tension between a liquid and a solid.

As used herein, the term“stabilizer(s)” refers to a substance capable of imparting resistance against physical or chemical deterioration or deformulation.

As used herein, the term“defoaming agent(s)” refers to a chemical additive that reduces and hinders the formation of foam in the industrial process liquids, semi-solids, or solids. The terms defoaming agent and anti-foaming agent can be used interchangeably.

As used herein, the term“thickener(s)” refers to a polymeric material, which at a low concentration increases the viscosity of an aqueous solution and helps to stabilize the composition.

Unless otherwise specified, % refers to % weight; and % weight refers to % of the weight of the respective component with respect to the total weight of the composition.

As used herein, the term“locus" means a plant, plant parts, plant propagation material (preferably seed), soil, area, material or environment in which a pest is growing or may grow.

As used herein, the term“plant parts” are understood to mean all above-ground and below-ground parts and organs of plants, such as shoot, leaf, flower and root, examples including leaves, needles, stems, stalks, flowers, fruit-bodies, fruits and seeds, and also roots, tubers and rhizomes. The plant parts also include harvested plants and vegetative and generative propagation material, for example seedlings, tubers, rhizomes, cuttings and seeds.

As used herein, the term "effective amount" means the amount of the active substances in the compositions to achieve an observable effect on growth, including the effects of necrosis, death, retardation, prevention, and removal, destruction, or otherwise diminishing the occurrence and activity of the target organism. The effective amount can vary for the various compositions used in the present invention. An effective amount of the compositions will also vary according to the prevailing conditions such as desired pesticidal effect and duration, weather, target species, locus, mode of application, and the like.

As used herein, the term“chlorantraniliprole”encompasses chlorantraniliprole or its agrochemically acceptable salt(s), ester(s), derivative(s) or any other modified form of chlorantraniliprole.

As used herein, the term“picoxystrobin” encompasses picoxystrobin or its agrochemically acceptable salt(s), ester(s), derivative(s) or any other modified form ofpicoxystrobin.

As used herein, the term “propiconazole” encompasses propiconazole or its agrochemically acceptable salt(s), ester(s), derivative(s) or any other modified form of propiconazole.

Accordingly, the present invention provides a synergistic combination of chlorantraniliprole, picoxystrobin and propiconazole, wherein optionally, the addition of one or more insecticidal or fungicidal or acaricidal or nematicidal or herbicidal compounds or any combination thereof is possible.

In one embodiment, the present invention provides a synergistic combination of chlorantraniliprole, picoxystrobin and propiconazole to control a wide variety of undesired phytopathogenic microorganisms, insect pests and mites.

In one embodiment, the present invention provides a synergistic fungicidal and insecticidal combination of chlorantraniliprole, picoxystrobin and propiconazole.

In another embodiment, the present invention provides a longer residual control of the undesired phytopathogenic microorganisms, insect pests and mites treated with the combination of chlorantraniliprole, picoxystrobin and propiconazole. The combination ratio of chlorantraniliprole, picoxystrobin and propiconazole depends on various factors such as, the undesired phytopathogenic microorganisms, insect pests and mites to be controlled, the degree of infestation, the climatic conditions, the characteristics of the soil and the application method, wherein the ratio of chlorantraniliprole, picoxystrobin and propiconazole is from 1: 10: 20 to 1: 2: 3, more preferably 1: 5: 10 to 1: 2: 3, most preferably 1: 3: 5 to 1: 2: 3.

In one embodiment, the present invention provides a synergistic composition of chlorantraniliprole, picoxystrobin and propiconazole for the control of a wide variety of undesired phytopathogenic microorganisms, insect pests and mites.

In another embodiment, the present invention provides a synergistic composition of chlorantraniliprole, picoxystrobin and propiconazole, wherein the composition is used as fungicidal and/or insecticidal composition.The composition is selected from suspension concentrate (SC), wettable granules (WG), wettable powder (WP), a water dispersible granule (WDG), a water dispersible tablet (WT), an ultra-low volume (ULV) liquid (UL), an ultra-low volume (ULV) suspension (SU), a water soluble powder (SP), a suspo-emulsion (SE), granule (GR), an emulsifiable granule (EG), an oil-in-water emulsion (EW), an emulsifiable concentrate (EC), a micro-emulsion (ME), an oil dispersion (OD), a capsule suspension (CS), a dustable powder (DP) or an aerosol (AE).

In a specific embodiment, the present invention provides a suspension concentrate (SC) composition of chlorantraniliprole, picoxystrobin and propiconazole.

In a specific embodiment, the present invention provides a suspo-emulsion (SE)composition of chlorantraniliprole, picoxystrobin and propiconazole.

In a specific embodiment, the present invention provides anemulsion concentrate (EC) composition of chlorantraniliprole, picoxystrobin and propiconazole.

In a specific embodiment, the present invention provides a wettable powder (WP) composition of chlorantraniliprole, picoxystrobin and propiconazole.

In a specific embodiment, the present invention provides wettable granules (WG) composition of chlorantraniliprole, picoxystrobin and propiconazole.

In a specific embodiment, the present invention provides a composition of chlorantraniliprole, picoxystrobin and propiconazole, wherein active ingredeients chlorantraniliprole, picoxystrobin and propiconazole, having a particle size of 5 to 60 pm, more preferably 5 to 30 pm, most preferably 5 to 10 pm.

In a specific embodiment, the present invention provides a composition of chlorantraniliprole, picoxystrobin and propiconazole, wherein active ingredeients having a particle size (d50, determined after dispersion in the water phase by laser diffraction) of 5 to 40 pm, more preferably 5 to 30 pm, most preferably 5 to 10 pm.

In a specific embodiment, the present invention provides a process for the prepation of composition of chlorantraniliprole, picoxystrobin and propiconazole, comprising the steps of a) addition of chlorantraniliprole, picoxystrobin and propiconazole or its acceptable salt(s) thereof,

b) addition of agrochemically acceptable additives selected from surfactant(s), carrier(s) and other additive(s) uniformly in a mixer;

c) optionally milling by a mill.

In a specific embodiment, the present invention provides a process for the prepation of suspension concentrate (SC) composition of chlorantraniliprole, picoxystrobin and propiconazole, comprising the steps

a) grinding picoxystrobin and chlorantranilipole separately with alkoxypolycarbonate to attain an average particle size of about 10 to 40 microns,

b) addition of agrochemically acceptable additives with suitable amount of water,

c) addition of propioconazole to the mixtures obtained in step (a) and (b) to obtain a homogeneous mixture.

d) addition of water at ambient temperature and millingto obtain suspension concentrate composition which has an average particle size of 5-7 nm.

The process for the prepation of suspension concentrate (SC) composition of step (a) involves attaining an average particle size of about 10 to 40 microns of picoxystrobin and chlorantranilipole separately by grinding with the alkylpolycarboxylate.

The process for the prepation of suspension concentrate (SC) composition step (b) involves the addition of the mixture of excipients with suitable amount of water, which is around 60 to 80 %. The process for the prepation of suspension concentrate (SC) composition step (c) involves the mixing the mixture obtained in step (a), step (b) and propioconazole to obtain a homogeneous mixture.

The process for the prepation of suspension concentrate (SC) composition step (d) involves the addition of water at ambient temperature, followed by cooling the mixture at temperature of about 15° C. The obtained mixture is processed in a colloidal mill at 10000 rpm for 20 minutes to form the suspension concentrate which has an average particle size of 5-7 nm.

These compositions may be manufactured by any process known in the art, such as,“Pesticide Formulation Guide” (edited by Pesticide Science Society of Japan, The Agricultural Formulation and Application Committee, published by Japan Plant Protection Association, 1997).

The composition of the present invention comprising of chlorantraniliprole, picoxystrobin and propiconazole in a wider ratio, in relation to various factors such as, crop type, the undesired phytopathogenic microorganisms, insect pests and mites to be controlled, the degree of infestation, the climatic conditions, the characteristics of the soil and the application method, wherein the weight ratio of chlorantraniliprole, picoxystrobin and propiconazole is from 1: 10: 20 to 1: 2: 3, more preferably 1: 5: 10 to 1: 2: 3, most preferably 1: 3: 5 to 1: 2: 3.

Accordingly, the present invention further provides a composition to control a wide variety of undesired phytopathogenic microorganisms, insect pests and mites, wherein the weight percentage of chlorantraniliprole is 0.5% to 10%, the weight percentage of picoxystrobin is 5% to 30% and the weight percentage of propiconazole is 8% to 50%. The total content of chlorantraniliprole, picoxystrobin and propiconazole in the composition is selected in the weight range typically from 15% to 80%, preferably from 20% to 60%.

The composition comprising organic or inorganic carrier material, including agriculturally acceptable additive(s) are selected from the group comprising of solid carrier(s), liquid carrier(s), gaseous carrier(s), surfactant(s), binder(s), disintegrating agent(s), pH adjuster(s), thickener(s), preservative(s), anti-caking agent(s), anti-freezing agent(s), defoaming agent(s), extender(s), stabilizer(s) and/or coloring agent(s) or a combination thereof. The composition may also contain if desired, one or more auxiliaries customary for crop protection compositions.

Solid carrier(s) is selected from the group comprising of, but not limited to, natural minerals such as quartz, talc, kaolin, pyrophyllite, montmorillonite, attapulgite, bentonite, chalk, zeolite, calcite, sericite, clay, acid clay, diatomaceous earth, Fuller’s earth, meerschaum, gibbsite, dolomite or pumice; synthetic minerals such as precipitated silica, fumed silica, sodium silicate, alumina, aluminum hydroxide; inorganic salts such as calcium carbonate, ammonium sulfate, sodium sulfate, potassium chloride, organic materials such as urea, solid polyoxyethylene, solid polyoxypropylene, polyethylene, polypropylene, lactose, starch, lignin, cellulose, cottonseeds hulls, wheat flour, soyabean flour, wood flour, walnut shell flour, plant powders, sawdust, coconut shellflower, corn cob, tobacco stem. These solid carriers may be used alone or in combination.

Liquid carrier(s) is selected from the group comprising of, but not limited to, water; alcohols such as ethanol, propanol, butanol, n-octanol, isopropanol ethylene glycol, diethylene glycol, propylene glycol, polyethylene glycol, benzyl alcohol, glycerin; polyol ethers such as ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, dipropylene glycol dimethyl ether; ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone; ethers such as dipropyl ether, dioxane, tetrahydrofuran, aliphatic hydrocarbons such as normal paraffin, isoparaffin, kerosene, mineral oil; aromatic hydrocarbons such as xylene, toluene, naphthene, solvent naphtha, solvent C9, solvent CIO, solvent C12, solvesso 100, solvesso 150, solvesso 200; chlorinated aliphatic or aromatics hydrocarbons such as chlorobenzene, chloroethylene, methylene chloride; esters such as ethyl acetate, diisopropyl phthalate, dimethyl adipate, methyl oleate, methyl tallowate; lactones such as gamma- butyrolactone, gamma-valerolactone, epsilon-caprolactone; amides such as dimethylformamide, N- methylpyrrolidone, N-octylpyrolidone, N,N-dimethyldecanamide; nitriles such as acetonitrile; organosulfur compound such as dimethyl sulfoxide; vegetable oils such as soybean oil, rapeseed oil, cotton seed oil. These liquid carriers may be used alone or in combination.

Gaseous carrier(s) is selected from the group comprising of, but not limited to, liquefied petroleum gas, air, nitrogen, carbon dioxide or dimethyl ether. These gaseous carriers may be used alone or in combination thereof.

Surfactant(s) (a dispersing agent, a wetting agent, a spreader, an adjuvant for penetration enhancement, rain fastness, soil leaching control etc.) are nonionic or anionic surfactants or a combination of these surfactants. It is preferred to use one or more than one kind of surfactant. Surfactant(s) is selected from the group comprising of, but not limited to, sugar esters such as sorbitan monolaurate, polyoxyethylene sorbitan monolaurate; C1-C30 alkylcarboxylate, C1-C20 hydroxyalkylcarboxylate, polymer containing carboxylate, arylcarboxylate, alkylx(e.g. aliphatic di- and tricarboxylates) having 2 to 32 carbon atoms, such as aconitic acid, adipic acid, aspartic acid, citric acid, fumaric acid, galactaric acid, glutamic acid, glutaric acid, oxoglutaric acid, maleic acid, malic acid, malonic acid, oxalate, sebacic acid, succinic acid, tartaric acid; alkyl polyglucoside such as decyl glucoside; polyoxyethylene alkyl ethers such as polyoxyethylene lauryl ether, or polyoxyethylene coconut fatty alcohol ether; polyoxyethylene alkynyl ether such as polyoxyethylene 2,4,7,9-tetramethyl-5-decyn-4,7-diol ether; polyoxyethylene aryl ethers such as polyoxyethylene nonylphenyl ether or polyoxyethylene tristyrylphenyl ether; polyoxyethylene vegetable oil ethers such as polyoxyethylene castor oil or polyoxyethylene hydrogenated castor oil; vegetable oil ethoxylate; C6-C20 linear and branched alcohol ethoxylates, C6-C20 alcohol propoxylates, C6-C20 propoxylated and ethoxylated alcohols ;poly oxye thy lene fatty acid esters such as polyoxyethylene monolaurate, polyoxyethylene distearate or polyoxyethylene resin acid ester; polyoxyethylene polyoxypropylene (EO-PO) block co-polymers such as Pluronic^®; polyoxyethylene polyoxypropylene alkyl ether such as polyoxyethylene polyoxypropylene lauryl ether; polyoxyethylene polyoxypropylene aryl ether such as polyoxyethylene polyoxypropylene styrylphenyl ether; polyoxyethylene alkyl amines such as polyoxyethylene stearyl amine; polyoxyethylene fatty acid amide such as lauric acid diethanolamid; fluorinated surfactant; alkyl sulfates such as sodium lauryl sulfate; sodium alkylbenzene sulfonate, calcium alkylbenzene sulphonate; polyoxyethylene alkyl ether sulfates such as sodium polyoxyethylene lauryl ether sulfate; polyoxyethylene aryl ether sulfates such as sodium polyoxyethylene nonylphenyl ether sulfate or ammonium polyoxyethylene tristyrylphenyl ether sulfate; aryl sulfonate such as calcium benzene sulfonate calcium dodecyl benzene sulfonate, sodium naphthalene sulfonate, sodium salt of naphthalene sulfonate condensate (MORWET® D-425) or sodium naphthalene sulfonate formaldehyde condensate; poly aryl phenyl ether sulphate ammonium salt;‘alpha’ -olefin sulfonate; lauryl sulfosuccinate, laureth sulfosuccinate, laureth-5 sulfosuccinate, ricinoleamide MEA sulfosuccinate, undecylenearnide MEA sulfosuccinate, diisobutyl sulfosuccinate, dioctyl sulfosuccinate, dihexylsulfosuccinate, dicyclohexyl sulfosuccinate, diisodecyl sulfosuccinate, diisotridecyl sulfosuccinate, di-2-ethylhexyl sulfosuccinate, di-2-methylamyl sulfosuccinate, dimethylamyl sulfosuccinate, dibutylhexyl sulfosuccinate, diisooctyl sulfosuccinate or their alkali metal salts, sodium lignosulfonate; polycarboxylic acid sodium salt; N-methyl fatty acid sarcosinate; polyoxyethylene alkyl ether phosphate; polyoxyethylene aryl ether phosphates such as polyoxyethylene phenyl ether phosphate; polyoxyethylene alkyl phenyl ether phosphate; graft co polymers such as polymethyl methacrylate -polyethylene glycol graft copolymer. These surfactants may be used alone or in combination thereof.

Binder(s) or adhesive-imparting agent(s) is selected from the group comprising of, but not limited to, polyvinyl alcohol, dextrin, denatured dextrin, soluble starch, guar gum, xanthan gum, sucrose, polyvinylpyrrolidone, gum arabic, polyvinyl acetate, sodium polyacrylate, carboxymethyl cellulose or its salt, carboxymethylcellulose dextrin, bentonite, polyethylene glycol having an average molecular weight of 6,000 to 20,000, polyethylene oxide having average molecular weight of 100,000 to 5,000,000, natural phosphatide such as cephalinic acid or lecithin. These binders or adhesive- imparting agents may be used alone or in combination thereof. Disintegrating agent(s) is selected from the group comprising of, but not limited to, sodium tripolyphosphate, stearic acid metal salt, cellulose powder, dextrin, methacrylate co-polymer, polyvinylpyrrolidone, polyaminocarboxylic acid chelate compound, styrene sulfonate/isobutylene/maleic anhydride co-polymer, starch/polyacrylonitrile graft co-polymer, sodium hexametaphosphate, carboxymethyl cellulose, sodium polycarbonate, bentonite. These disintegrating agents may be used alone or in combination thereof. pH adjuster(s) is selected from the group comprising of, but not limited to, sodium or potassium carbonate, sodium or potassium hydrogen carbonate, sodium or potassium dihydrogenphosphate, disodium or dipotassium hydrogenphosphate, citric acid, malic acid and triethanolamine. These pH adjusters may be used alone or in combination thereof.

Thickener(s) is selected from the group comprising of, but not limited to, polyvinyl alcohol, carboxymethylcellulose, polyvinylpyrrolidone, carboxyvinyl polymer, acrylic polymer, acrylic graft copolymer, starch derivative, synthetic macromolecules, such as modified cellulose-based polymers, polycarboxylates, montmorillonites, hectonites, attapulgites, polysaccharide gums such as gellan gum, jelutong gum, xanthan gum, guar gum, gum arabic, gum tragacanth, gum karya, tara gum, locust gum, agar agar, carrageenan, alginic acid, propylene glycol alginate, alginates (e.g. sodium, potassium, ammonium, or calcium), or an inorganic fine powder selected from high purity silica, bentonite, white carbon. These thickeners may be used alone or in combination thereof.

Preservative(s) is selected from the group comprising of, but not limited to, formaldehyde and paraformaldehyde, 2- hydroxybiphenyl ether and its salts, 2-zinc sulfidopyridine N-oxide, inorganic sulfites and bisulfites, sodium iodate, chlorobutanol, dehydroacetic acid, formic acid, 1, 6-bis (4- amidino-2- bromophenoxy)-n-hexane and its salts, 10-undecylenic acid and their salts, 5-amino-l,3- bis (2- ethylhexyl)-5-methyl-hexahydropyrimidine, 5-bromo-5-nitro-l,3-dioxane, 2-bromo-2-nitro-l,3 propanediol, 2, 4-dichlorobenzylalcohol, potassium sorbate, 4-hydroxybenzoic acid esters, dichlorophene, isothiazolenes and isothiazolones such as l,2-benzisothiazol-3(2H)-one(Proxel^® GXL),2-methyl-2H-isothiazol-3-one -hydrochloride, 5-chloro-2-(4-chlorobenzyl)-3(2H)- isothiazolone,5-chloro-2-methyl-2H-isothiazol-3-one,5-chloro-2-methyl-2H-isothiazol-3-one, 5- chloro-2-methyl-2H-isothiazol-3-one-hydrochloride, 4,5-dichloro-2-cyclohexyl- 4-isothiazolin-3-one, 4,5-dichloro-2-octyl-2H-isothiazol-3-one, 2-methyl-2H-isothiazol-3-one, 2-methyl-2H-isothiazol-3- one-calcium chloride complex, 2-octyl-2H-isothiazol- 3-one.These preservatives may be used alone or in combination thereof.

Anti-caking agent(s) is selected from the group comprising of, but not limited to, disodium benzene disulfonate, dipotassium benzene disulfonate, disodium toluene disulfonate, and dipotassium toluene disulfonate, glycol based aqueous solvents such as ethylene glycol, diethylene glycol, dipropylene glycol and propylene glycol, precipitated silica, fumed silica, aluminium silicate, magnesium silicate, sodium silicate, calcium silicate, talc, diatomaceous earth, bentonite, calcium carbonate, sodium carbonate, aluminium oxide, and talcum, cellulose, attapulgite clay, kieselguhr, silica aerogel, silica xerogel, perlite, talc, vermiculite, sodium aluminosilicate, zirconium oxychloride, starch, sodium or potassium phthalate, calcium phosphate, calcium nitride, aluminum nitride, copper oxide, magnesium carbonate, magnesium nitride, magnesium phosphate, magnesium oxide, magnesium nitrate, magnesium sulfate, magnesium chloride, magnesium oxide, magnesium and aluminum salts of C10- C22 fatty acids such as palmitic acid, stearic acid and oleic acid, tricalcium phosphate, hydrophobic starch derivatives, powdered cellulose, polyacrylic acid and sodium salts thereof, and sodium polyalkyl naphthalene sulfonate. These anti-caking agents may be used alone or in combination thereof.

Anti-freezing agent(s) is selected from the group comprising of, but not limited to, urea, glycerine, ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, trimethylene glycol, 1,2- butanediol, 1,3-butanediol, 1 ,4-butanediol, 1 ,4-pentanediol, 3-methyl- 1,5-pentanediol, 2,3-dimethyl- 2,3-butanediol, trimethylol propane, mannitol, sorbitol, glycerol, pentaerythritol, 1,4- cyclohexanedimethanol, xylenol, bisphenols such as bisphenol A or the like, propylene glycol, glycerol, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, triethylene glycol monomethyl ether, butoxyethanol, butylene glycol monobutyl ether, dipentaerythritol, tripentaerythritol, tetrapentaerythritol, diglycerol, triglycerol, tetraglycerol, pentaglycerol, hexaglycerol, heptaglycerol and octaglycerol. These anti-freezing agents may be used alone or in combination thereof.

Defoamer(s) is selected from the group comprising of, but not limited to, silicone compounds such as polysiloxane, polydimethyl siloxane, silicone oil, magnesium stearate, long chain alcohol, fatty acid, salts of fatty acid and organic fluorine compounds. These defoaming agents may be used alone or in combination thereof.

Extender(s) is selected from the group comprising of, but not limited to, silicon type surfactant, a cellulose powder, dextrin, processed starch, a polyaminocarboxylic acid chelate compound, crosslinked polyvinylpyrrolidone, maleic acid and styrene, methacrylic acid co-polymer, half ester of polymer of polyhydric alcohol with dicarboxylic anhydride, water-soluble salt of polystyrene sulfonic acid. These extenders may be used alone or in combination thereof.

Stabilizer(s) is selected from the group comprising of, but not limited to, drying agent such as zeolite, quick lime or magnesium oxide; antioxidant agent such as phenol type, amine type, sulfur type or phosphorus type; or ultraviolet absorber such as salicylic acid type or a benzophenone type. These stabilizers may be used alone or in combination thereof.

Coloring agent(s) is selected from the group comprising of, but not limited to, inorganic pigment such as iron oxide, titanium oxide or Prussian blue; organic dye such as alizarin dye, azo dye, metal phthalocyanine dye. These coloring agents may be used alone or in combination thereof.

When additive ingredients are incorporated into the composition of the present invention, the content of the carrier is selected typically in weight range from 5% to 95%, preferably from 20% to 90%; the content of the surfactant is selected from the range of typically from 0.1% to 30%, preferably from 0.5% to 10%, and the content of the other additives is selected from the range of typically from 0.1% to 50%.

The composition of the present invention can be applied by any one of the methods selected from atomization, spreading, dusting, spraying, diffusion, immersion, irrigation, injection, mixing, sprinkling (water immersion), foaming, dressing, coating, blasting, fumigation, smoking, smog and painting.

In an embodiment, the present invention provides a method of controllinga wide variety of undesired phytopathogenic microorganisms, insect pests and mites, with an effective amount of a composition of chlorantraniliprole, picoxystrobin and propiconazole.

In an embodiment, the present invention provides a method for controlling undesired phytopathogenic microorganisms with an effective amount of a synergistic composition of chlorantraniliprole, picoxystrobin and propiconazole.

The undesired pathogenic microorganism for the present invention is selected from the group comprising of Albugo spp. (white rust) on ornamentals, vegetables (e.g.A. Candida) and sunflowers (e.g.A. tragopogonis), Alternaria spp. (Alternaria leaf spot) on vegetables, citrus fruits (A. citri), rape (A. brassicola or brassicae), sugar beets (A. tenuis), fruits, rice, soybeans, potatoes (e.g.A. solani or A. alternata), tomatoes (e.g.A. solani or A. alternata) and wheat; Aphanomyces spp. on sugar beets and vegetables; Ascochyta spp. on cotton, cereals and vegetables, e.g.A. tritici (anthracnose) on wheat and A. hordei on barley; Bipolaris and Drechslera spp. (teleomorph: Cochliobolus spp. for e.g. Cochliobolus carbonum (northern corn leaf blight)), e.g. Southern leaf blight (D. maydis) or Northern leaf blight ( B . zeicola) on corn, e.g. spot blotch (B. sorokiniana) on cereals, e.g. B. oryzae on rice and turfs and on oats; Blumeria (formerly Erysiphe) graminis (powdery mildew) on cereals (e.g. on wheat or barley); Botrytis cinerea (teleomorph: Botryotinia fuckeliana: grey mold) on fruits and berries (e.g. strawberries), vegetables (e.g. lettuce, carrots, celery and cabbages), rape, flowers, vines, forestry plants and wheat; Bremia lactucae (downy mildew) on lettuce; Ceratocystis (syn. Ophiostoma ) spp. (rot or wilt) on broadleaved trees and evergreens, e.g.C. ulmi (Dutch elm disease) on elms; Cercospora spp. (Cercospora leaf spots) on corn and cotton, (Cercospora blight spots) on cotton, (e.g. Gray leaf spot: C. zeae-maydis ), rice, sugar beets (e.g.C. beticola), sugar cane, vegetables, coffee, soybeans (e.g.C. sojina or C. kikuchii ) and rice, sunflower (e.g. cercospora leaf spot: C. helianthi), peanut (e.g. early leaf spot: C. arachidicold), Cercosporidium spp. on peanut (e.g. C. personation: late leaf spot); Cladosporium spp. on tomatoes (e.g.C. fulvum: leaf mold) and cereals, e.g.C. herbarum (black ear) on wheat, C. caryigenum (pecan scab) on pecan; Cylindrocladium spp. on peanut (C. crotalariae: cylindrocladium black rot ) Claviceps purpurea (ergot) on cereals Cochliobolus (anamorph: Helminthosporium of Bipolaris ) spp. (leaf spots) on corn (C. carbonum), cereals (e.g.C. .srvr/vr/.sf black point), anamorph: B. sorokiniand) and rice (e.g.C. miyabeanus, anamorph: H. oryzae) Colletotrichum (teleomorph: Glomerella ) spp. (anthracnose) on cotton (e.g.C. gossypii), corn (e.g.C. graminicola: Anthracnose stalk rot), soft fruits, potatoes (e.g. C. coccodes: black dot), beans (e.g.C. Bndemuthianum), citrus fruits (e.g.C. acutatum{ post bloom fruit drop), C. gloeosporioides) and soybeans (e.g. C. truncatum or C. gloeosporioides), Corticium spp., e.g. C. sasakii (sheath blight) on rice; Corynespora cassiicola (leaf spots) on soybeans and ornamentals; Cycloconium spp., e.g. C. oleaginum on olive bees; Cylindrocarpon spp. (e.g. fruit tree canker or young vine decline, teleomorph: Nectria or Neonectria spp.) on fruit trees, vines (e.g.C. liriodendri, teleomorph: Neonectria liriodendri: Black Foot Disease) and ornamentals; Dematophora (teleomorph: Rosellinia ) necatrix (root andstem rot) on soybeans; Diplodia spp. e.g. Diplodia boll rot on cotton, Diaporthe spp., e.g .D. phaseolorum (damping off) on soybeans, D. citri (melanose) on citrus fruits; Drechslera (syn. Helminthosporium, teleomorph: Pyrenophora ) spp. on corn, cereals, such as barley (e.g .D. teres, net blotch), oats (e.g. D. avenae, leaf spot), and wheat (e.g .D. tritici-repentis: tan spot), rice and turf; Esca (dieback, apoplexy) on vines, caused by Formitiporia (syn. Phellinus ) punctata, F. mediterranea, Phaeomoniella chlamydospora (earlier Phaeoacremonium chlamydosporum), Phaeoacremonium aleophilum and/or Botryosphaeriaobtusa Elsinoe spp. on pome fruits ( E . pyri ), on citrus fruits ( E . fawcetti ), soft fruits (E. veneta: anthracnose) and vines (E. ampelina: anthracnose); Entyloma oryzae (leaf smut) on rice; Epicoccum spp. (black mold) on wheat; Erysiphe spp. (powdery mildew) on sugar beets (E. betae), (powdery mildew) on rye (E. graminis), vegetables (e.g .E. pisi ), such as cucurbits (e.g .E. cichoracearum), cabbages, sunflower, rape(e.g.E. cruciferarum), peas and bean (e.g. E. polygoni), Eutypa lata (Eutypa canker or dieback, anamorph: Cytosporinalata, syn. Libertella blepharis ) on fruit trees, vines and ornamental woods; Exserohilum(syn. Helminthosporium ) spp. on corn (e.g .E. turcicum), Fusarium (teleomorph: Gibberella) spp. (wilt, root or stem rot) on various plants, such as hardlock, boll rot of cotton, F. graminearum or F.culmorum (root rot, scab or head blight) on cereals (e.g. wheat or barley), F. oxysporumon tomatoes, F. solani on soybeans and F. verticillioides on corn; Gaeumannomycesgraminis (take-all patch) on cereals (e.g. wheat or barley) and corn; Gibberella spp. on cereals (e.g .G. z.eae) and rice (e.g .G. fujikuroi: Bakanae disease); Glomerella cingulata on vines, pome fruits and other plants and G. gossypii on cotton; Grain staining complex on rice; Guignardia bidwellii (black rot) on vines, Guignardia citricarpa (balck spot) on citrus fruits; Gymnosporangium spp. on rosaceous plants and junipers, e.g.G. sabinae (rust) on pears; Helmintho sporium spp. (syn. Drechslera, teleomorph: Cochliobolus ) on corn, cereals and rice; Hemileia spp., c.g.H. vastatrix (coffee leaf rust) on coffee; Isariopsis clavispora (syn. Cladosporium vitis ) on vines; Kabatiella zeae (eyespot) on corn; Laetisaria fuciformis (red thread); Limonomyces roseipellis (pink patch); Leptosphaeria maculans (blackleg) on oilseed crops, Leptosphaeria korrae and Leptosphaeria namari on bluegrass, Ophiosphaerella herpotricha on bermudagrass; Leptosphaerulina spp. on peanut (e.g. L. crassiasca : pepperspot); Macrophomina phaseolina (syn. phaseoli ) (root and stem rot) on soybeans and cotton; Microdochium (syn. Fusarium ) nivale (pink snow mold) on cereals (e.g. wheat or barley); Microsphaera diffusa (powdery mildew) on soybeans; Myeosphaerella citri (greasy spot) on citrus fruit, Monilinia spp., e.g M. laxa, M. fructicola and M. fructigena (bloom and twig blight, brown rot) on stone fruits and other rosaceous plants; Myeosphaerella spp. on peas and beans, cereals, bananas, soft fruits and ground nuts, such as e.g M. graminicola (anamorph: Septoria tritici, Septoria blotch ) on wheat or M. fijiensis (black Sigatoka disease) on bananas Peronospora spp. (downy mildew) on cabbage (e.g .P. brassicae), rape (e.g .P. parasitica), onions (e.g .P. destructor), tobacco (P. tabacind) and soybeans (e.g .P. manshuricaf, Phyllosticta maydis (yellow leaf blight) on corn; Phakopsora pachyrhizi and P. meibomiae (soybean rust) on soybeans; Phialophora spp. e.g. on vines (e.g .P. tracheiphila and P. tetraspora ) and soybeans (e.g .P. gregata : stem rot); Phoma lingam (root and stem rot) on rape and cabbage and P. betae (root rot, leaf spot and damping-off) on sugar beets, Phoma exigua (ascochyta blight) on peas and beans, phoma blight, boll rot on cotton, Phoma arachidicola (web blotch) on peanut; Phomopsis spp. on sunflowers, vines (e.g .P. viticola: can and leaf spot) and soybeans (e.g. stem rot: phaseoli, teleomorph: Diaporthe phaseolorum) Phykopsora spp. e.g. rust on cotton, Physoderma maydis (physoderma brown spot) on corn; Phytophthora spp. (wilt, root, leaf, fruit and stem root) on various plants, such as paprika and cucurbits (e.g .P. capsid), soybeans (e.g .P. megasperma, syn. P. sojae), potatoes and tomatoes (e.g .P. infestans: late blight), broad-leaved bees (e.g .P. ramorum : sudden oak death) and peas and beans (e.g. P. nicotianae : downy mildew); Plasmodiophora brassicae (club root) on cabbage, rape, radish and other plants; Plasmopara spp., e.g .P. viticola (downy mildew) on vines and P. halstedii on sunflowers; Podosphaera spp. (powdery mildew) on rosaceous plants, hop, pome and soft fruits, e.g .P. leucotricha on apples; Polymyxa spp., e.g. on cereals, such as barley and wheat (P. graminis) and sugar beets (P. betae) and thereby transmitted viral diseases; Pseudocercosporella herpotrichoides (eyespot, teleomorph: Tapesia yallundae) on cereals, e.g. wheat or barley; Pseudoperonospora (downy mildew) on various plants, e.g .P. cubensis on cucurbits or P. humili on hop; Pseudopezicula tracheiphila (red fire disease or rotbrenner, anamorph: Phialophora) on vines; Puccinia spp. (rusts) on various plants, e.g .P. dichondrae (dichondra rust), P. tritidna (brown or leaf rust), P. striiformis{ stripe or yellow rust), P. hordei (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust) on cereals, such as e.g. wheat, barley or rye ( P . reconditd), P. kuehnii (orange rust) on sugar cane and P. asparagi on asparagus, P. coronata (crown rust) and P. graminis (stem rust) on oats, P. arachidis (rust) on peanut; Pyrenophora (anamorph: Drechslerd) tritici- repentis (tan spot) on wheat, P. feres (net blotch) on barley, or P. avenae (leaf blotch) on oats; Pyricularia spp., e.g .P. oryzae (teleomorph: Magnaporthe grisea, rice blast) on rice, Magnaporthe poae (summer patch) on Kentucky bluegrass and P. grisea(gra leafspot) on turf and cereals; Pythium spp. (damping-off) on turf, rice, corn, wheat, cotton, rape, sunflowers, soybeans, sugar beets, vegetables and various other plants (e.g .P. ultimum or P. aphanidermcitum)·, Ramularia spp., e.g .R. collo-cygni ( Ramularia leaf spots, physiological leaf spots) on barley and mint, and R. beticola on sugar beets; Rhizoctonia spp. on cotton, rice, potatoes, turf, corn, rape, potatoes, sugar beets, vegetables and various other plants, e.g .R. solani( brown patch) (root and stem rot) on soybeans, R. solani (sheath blight) on rice and peanut, or R. cerealis (Rhizoctonia spring blight) on wheat or barley; Rhizopus stolonifer (black mold, soft rot) on strawberries, carrots, cabbage, vines and tomatoes; Rhynchosporium secalis (scald) on barley, rye and triticale; Sarocladium oryzae and S. attenuatum (sheath rot) on rice; Sclerotinia spp. (stem rot or white mold) on vegetables and field crops, such as rape, sunflowers (e.g.S. sclerotiorum) and soybeans (e.g.S. rolfsii or S. sclerotiorum), Sclerotinia homoeocarpa (Dollar spot), S. minor (sclerotinia blight) on peanut, S. sclerotiorum (white mold) on potato; Sclerotium spp. on peanut (e.g. S. rolfsii), Septoria spp. on various plants, e.g.S. glycines (brown spot) on soybeans, S. tritici (Septoria blotch) on wheat, S. avenae (septoria blotch) on oats, S. linicola (pasmo) on flax seed; Uncinula ( syn.Erysiphe ) necator (powdery mildew, anamorph: Oidium tuckeri) on vines; Setospaeria spp. (leaf blight) on corn (e.g.S. turcicum, syn. Helminthosporium turcicum) and turf; Sphacelotheca spp. (smut) on corn, (e.g.S. reiliana: head smut), sorghum und sugarcane; Sphaerotheca fuliginea (powdery mildew) on cucurbits; Spongospora subterranea( powdery scab) on potatoes and thereby transmitted viral diseases; Stagonosporaspp. on cereals, e.g.S. nodorum (Stagonospora blotch, teleomorph: Leptosphaeria(syn.

Phaeosphaeria)nodorum) on wheat, septrotia leaf and glume blotch on ry e StemphyUium spp. e.g. stemphyhium leaf spot on cotton, Synchytrium endobioticum on potatoes (potatowart disease); Taphrina spp., e.g .T. deformans (leaf curl disease) on peachesand T. pruni (plum pocket) on plums; Thielaviopsis spp. (black root rot) on tobacco, pome fruits, vegetables, soybeans and cotton, e.g .T. basicola (syn. Chalara elegansfTilletia spp. (common bunt or stinking smut) on cereals, such as e.g .T. tritici (syn. T. canes, wheat bunt) and T. controversa (dwarf bunt) on wheat; Typhula incarnata (grey snow mold) on barley or wheat; Urocystis spp., e.g .U. occulta (stem smut) on rye, U. agropyn on wheat; Uromyces spp. (rust) on vegetables, such as beans (e.g .U. appendiculatus, syn. U. phaseoli) and sugar beets (e.g .U. betae) ; Ustilago spp. (loose smut) on cereals (e.g .U. nuda and U. avaenae), corn (e.g .U. maydis: corn smut) and sugar cane, U. striiformis (stripe smut) on grasses grown for turf; Venturia spp. (scab) on apples (e.g. V. inaequalis) and pears; and Verticillium spp. (wilt) on various plants, such as fruits and ornamentals, vines, soft fruits, vegetables and field crops, e.g.V. dahliae on strawberries, rape, potatoes and tomatoes.

In a preferred embodiment, the present invention provides a fungicidal or insecticidal combination or composition comprising of chlorantraniliprole, picoxystrobin and propiconazole to control the undesired pathogenic microorganisms selected from the group comprising of, but not limited to, powdery mildew, dollar spot, anthracnose, brown patch, pink patch, red thread, red stalk rot of cereals, collar rot, stripe smut, gray leafspot, melting out leafspot, Australian carpet beetle, summer patch, poa patch, take-all patch, spring dead spot, necrotic ring spot, pink snowmold, fusarium patch, yellow patch, zoysia patch, stem rust, dichondra rust, crown rust, brown rust, yellow rust, stripe smut, leaf blights, rhizoctonia spring blight, sheath blight, sooty mold, pink snow mold, and sclerotinia.

The combination or composition of the present invention is also suitable for controlling the undesired pathogenic microorganisms occurring in plant parts, in the protection of materials (e.g. wood, paper, paint dispersions, fiber or fabrics) and in the protection of stored products. The term "protection of materials" is to be understood to denote the protection of technical and non-living materials, such as adhesives, glues, wood, paper and paperboard, textiles, leather, paint dispersions, plastics, cooling lubricants, fiber or fabrics, against the infestation and destruction by undesired pathological microorganisms, such as fungi and bacteria. As to the protection of wood and other materials, the particular attention is paid to the following undesired pathogenic microorganisms: Ascomycetes such as Ophiostoma spp., Ceratocystis spp., Aureobasidium pullulans, Sclerophoma spp., Chaetomium spp., Humicola spp., Petriella spp., Trichurus spp.; Basidiomycetes such as Coniophora spp., Coriolus spp., Gloeophyllum spp., Lentinus spp., Pleurotus spp., Poria spp., Serpula spp. and Tyromyces spp., Deuteromycetes such as Aspergillus spp., Cladosporium spp., Penicillium spp., Trichorma spp., Alternaria spp., Paecilomyces spp. and Zygomycetes such as Mucor spp., and in addition in the protection of stored products the following undesired pathogenic microorganisms are worthy of note: Candida spp. and Saccharomyces cerevisae.

The combination or composition of the present invention also provides a nonagronomic (other than field crops) application such as application on horticultural crops (e.g., greenhouse, nursery or ornamental plants not grown in a field), residential, commercial and industrial structures, turf (e.g., sod farm, pasture, golf course, lawn, sports field, etc.).

In an embodiment, the present invention provides a method for controllinginsect pests and mites with an effective amount of the composition of chlorantraniliprole, picoxystrobin and propiconazole. Insect pests or mites is selected from the order of moths and butterflies ( Lepidoptera ), beetles (Coleoptera), flies, mosquitoes ( Diptera ), thrips ( Thysanoptera ), termites ( Isoptera ), cockroaches (Blattaria - Blattoded), true bugs ( Hemiptera ), crickets, grasshoppers, locusts ( Orthoptera ), arachnids (. Acarina ), fleas ( Siphonaptera ), silverfish, firebrat ( Thysanura ), millipedes ( Diplopoda ), earwigs ( Dermaptera ), lice ( Phthiraptera ), or plant parasitic nematodes.

In afurther embodiment of the present invention defines the insect pests and mites from the ordersof: lepidopterans ( Lepidoptera ), for example Agrotis ypsilonAgrotis segetum (cutworm), Alabama argillacea, Anticarsia gemmatalis, Argyresthia conjugella,Autographa gamma, Bupalus piniarius, Cacoecia murinana, Capua reticulana, Cheimatobiabrumata, Choristoneura fumiferana, Choristoneura occidentalis , Cirphisunipuncta, Cydia pomonella, Cydia caryana (hickory shuckworm), Dendrolimus pini, Diaphania nitidalis, Diatraea grandosella, Earias insulana, Elasmopalpus lignosellus, Eupoecilia ambiguella, Evetria bouliana, Feltia subterranea, Galleria mellonella, Grapholitha funebrana, Grapholitha molesta,Heliothis armigera, Heliothis vi rescensitobd' cco budworm), Heliothis zea, Hellula undalis, Hiberniadefoliaria, Hyphantria cunea, Hyponomeuta malinellus, Keiferia lycopersicella, Lambdina fiscellaria, Laphygma exigua, Leucoptera coj eella, Leucoptera scitella, Lithocolletis blancardella, Lobesia botrana, Loxostege sticticalis, Lymantria dispar, Lymantria monacha, Lyonetia clerkella, Malacosoma neustria, Mamestra brassicae, Orgyia pseudotsugata,Ostrinia nubilalis(e. uropean corn borer), Panolis flammea, Pectinophora gossypiellaipm bollworm), Peridroma saucia, Phalera bucephala, Phthorimaea operculella, Phyllocnistis citrella, Pieris brassicae, Pieris rapae (imported cabbageworm), Plathypena scabra, Plutella xylostella, Pseudoplusia includens, Rhyacionia frustrana, Scrobipalpula absoluta, Sitotroga cerealella, Sparganothis pilleriana, Spodoptera frugiperdadaW armyworm), Spodoptera littoralis, Spodoptera litura, Thaumatopoea pityocampa, Tortrix viridana, Trichoplusia ni, Zeiraphera canadensis, Giant swallowtail (orangedog), Paralobesia viteana (grape berry moth), Desmia funeralis (grape leaffolder) ,Helicoverpa zea (corn earworm), Helicoverpa armigeral (cotton bollworm), Agrotis segetum, Agrotis ipsilon, Agrotis exclamationis ,M anduca quinquemaculata (tomato hornworm), Lithophane antennata (green fruitworm), Lithophane unimoda, Orthosia hibisci, Anarsia lineatella (peach twig borer), Acrobasis nuxvorella (pecan nut casebearer), Amyelois transitella (navel orange worm), Marmara gulosa (Citrus peelminer)and Harrisina Americana (Grapeleaf skeletonizer), beetles (Coleoptera), for example Agrilus sinuatus, Agriotes lineatus, Agriotes obscurus, Amphimallus solstitialis, Anisandrus dispar, Anthonomus grandis, Anthonomus pomorum, Aphthona euphoridae, Athous haemorrhoidalis, Atomaria linearis, Blastophagus piniperda, Blitophaga undata, Bruchus rufimanus, Bruchus pisorum, Bruchus lends, Byctiscus betulae, Cassida nebulosa, Cerotoma trifurcata, Cetonia aurata, Ceuthorrhynchus assimilis, Ceuthorrhynchus napi, Chaetocnema tibialis, Conoderus vespertinus, Crioceris asparagi, Ctenicera ssp., Curculio caryae (pecan weevil), Diabrotica longicornis, Diabrotica semipunctata, Diabrotica 12-punctata, Diabrotica speciosa, Diabrotica virgifera, Epilachna varivestis, Epitrix hirtipennis, Eutinobothrus brasiliensis, Hylobius abietis, Hypera brunneipennis, Hypera postica, Ips typographus, Lema bilineata, Lema melanopus, Leptinotarsa decemlineata{ Colorado potato beetle), Limonius califomicus, Lissorhoptrus oryzophilus, Melanotus communis, Meligethes aeneus, Melolontha hippocastani, Melolontha melolontha,Oulema oryzae, Ortiorrhynchus sulcatus, Otiorrhynchus ovatus, Phaedon cochleariae, Phyllobius pyri, Phyllotreta chrysocephala, Phyllophaga sp., Phyllopertha hordeola, Phyllotreta nemorum, Phyllotreta striolata, Popillia japonica{ Japanese beetle), Sitona lineatus, Sitophilus granaria, Diaprepes abbreviatus, and Conotrachelus nenuphar (plum curculio), flies, mosquitoes ( Diptera ), e.g. Aedes aegypti, Aedes albopictus, Aedes vexans, Anastrepha ludens, Anopheles maculipennis, Anopheles crucians, Anopheles albimanus, Anopheles gambiae, Anopheles freeborni, Anopheles leucosphyrus, Anopheles minimus, Anopheles quadrimaculatus, Calliphora vicina, Ceradtis capitata, Chrysomya bezziana, Chrysomya hominivorax, Chrysomya macellaria, Chrysops discalis, Chrysops silacea, Chrysops adanticus, Cochliomyia hominivorax, Contarinia sorghicola Cordylobia anthropophaga, Culicoides furens, Culex pipiens, Culex nigripalpus, Culex quinquefasciatus, Culex tarsalis, Culiseta inornata, Culiseta melanura, Dacus cucurbitae, Dacus oleae, Dasineura brassicae, Delia antique, Delia coarctata, Delia platura, Delia radicum, Dermatobia hominis, Drosophila suz.ukii (spotted wing drosophila ),Fannia canicularis, Geomyza Tripunctata, Gasterophilus intestinalis, Glossina morsitans, Glossina palpalis, Glossina fuscipes, Glossina tachinoides, Haematobia irritans, Haplodiplosis equestris, Hippelates spp., Hylemyia platura, Hypoderma lineata, Leptoconops torrens, Liriomyza sativae, Liriomyza trifolii, Lucilia caprina, Lucilia cuprina, Lucilia sericata, Lycoria pectoralis, Mansonia titillanus, Mayetiola destructor, Musca domestica, Muscina stabulans, Oestrus ovis, Opomyza florum, Oscinella frit, Pegomya hysocyami, Phorbia antiqua, Phorbia brassicae, Phorbia coarctata, Phlebotomus argendpes, Psorophora columbiae, Psila rosae, Psorophora discolor, Prosimulium mixtum, Rhagoletis cerasi, Rhagoleds pomonellal (apple maggot), Sarcophaga haemorrhoidalis, Sarcophaga sp., Simulium vittatum, Stomoxys calcitrans, Tabanus bovinus, Tabanus atratus, Tabanus lineola, Tabanus similis, Tipula oleracea, Tipula paludosa, and Rhagoletis cerasi (cherry fruit fly), th ri ps( Thysanoptera), e.g. Dichromothrips corbetti, Dichromothrips ssp., Frankliniella fusca, Frankliniella occidentalis, Frankliniella tritici, Scirtothrips citri( Citrus thrips), Thrips oryzae, Thrips palmi, Thrips tabaci, and Drepanothrips reuteri (grape thrips) termites ( Isoptera ), e.g. Calotermes flavicollis, Leucotermes flavipes, Heterotermes aureus, Reticulitermes flavipes, Reticulitermes virginicus, Reticulitermes lucifugus, Termes natalensis, and Coptotermes formosanus, cockroaches (Blattaria - Blattodea), e.g. Blattella germanica, Blattella asahinae, Penplaneta americana, Periplaneta japonica, Periplaneta brunnea, Periplaneta fuligginosa,Periplaneta australasiae, and Blatta orientalis,

true bugs ( Hemiptera ), e.g. Diaphorina citri, Acrosternum hilare, Blissus leucopterus, Cyrtopeltis notatus, Dysdercus cingulatus, Dysdercus intermedius, Eurygaster integriceps, Euschistus impictiventris, Leptoglossus phyllopus, Lygus lineolaris, Lygus pratensis, Nezara viridula, Piesma quadrata, Solubea insularis , Thyanta perditor, Acyrthosiphon onobrychis, Adelges laricis, Aphidula nasturtii, Aphis fabae, Aphis forbesi, Aphis pomi, Aphis gos sypii, Aphis grossulariae, Aphis schneideri, Aphis spiraecola, Aphis sambuci, Acyrthosiphon pisum, Aulacorthum solani, Bemisia argentifolii, Brachycaudus cardui, Brachycaudus helichrysi, Brachycaudus persicae, Brachycaudus prunicola, Brevicoryne brassicae, Capitophorus horni, Cerosipha gossypii, Chaeto siphon fragaefolii, Cryptomyzus ribis, Dreyfusia nordmannianae, Dreyfusia piceae, Dysaphis radicola, Dysaulacorthum pseudosolani, Dysaphis plantaginea, Dysaphis pyri, Empoasca fabae, Hyalopterus pruni, Hyperomyzus lactucae, Macrosiphum avenae, Macrosiphum euphorbiae, Macrosiphon rosae, Megoura viciae, Melanaphis pyrarius, Metopolophium dirhodum, Myzus persicae, Myzus ascalonicus, Myzus cerasi, Myzus varians, Nasonovia ribis-nigri, Nilaparvata lugens, Pemphigus bursarius, Perkinsiella saccharicida, Phorodon humuli, Psylla mail, Psylla piri, Rhopalomyzus ascalonicus, Rhopalosiphum maidis, Rhopalosiphum padi, Rhopalosiphum insertum, Sappaphis mala, Sappaphis mall, Schizaphis graminum, Schizoneura lanuginosa, Sitobion avenae, Trialeurodes vaporariorum,Toxoptera aurantiiaud, Viteus vitifolii, Cimex lectularius, Cimex hemipterus, Reduvius senilis, Triatoma spp., Cicadella viridis (green leafhoppers), Bactericera cockerelli (potato psyllid), Arilus critatus,Planococcus citri (citrus mealybug ), Pseudococcus maritimus (grape mealybug), Pseudatomoscelis seriatus (cotton fleahopper), Proxys punctulatus (black stink bug), Halyomorpha halys, Citricola scale ( Coccus pseudomagnoliarum), Barnacle sc a 1 c ( Ce ro p I a s tes cirripediformis), and Brown soft scale ( Coccus hesperidum), ants, bees, wasps, sawflies ( Hymenoptera ), e.g. Athalia rosae, Atta cephalotes, Atta capiguara, Atta cephalotes, Atta laevigata, Atta robusta, Atta sexdens, Atta texana, Crematogasterspp., Hoplocampa minuta, Hoplocampa testudinea, Monomorium pharaonis, Solenopsis geminata, Solenopsis invicta, Solenopsis richteri, Solenopsis xyloni, Pogonomyrmex barbatus, Pogonomyrmex californicus, Pheidole megacephala, Dasymutilla occidentalis, Bombus spp. Vespula squamosa, Paravespula vulgaris, Paravespula pennsylvanica, Paravespula germanica, Dolichovespula maculata, Vespa crabro, Polistes rubiginosa, Camponotus floridanus, and Linepithema humile, crickets, grasshoppers, locusts ( Orthoptera ), e.g. Acheta domestica, Gryllotalpa gryllotalpa, Locusta migratoria, Melanoplus bivittatus, Melanoplus femurrubrum, Melanoplus mexicanus, Melanoplus sanguinipes, Melanoplus spretus, Nomadacris septemfasciata, Schistocerca americana, Schistocerca gregaria, Dociostaurus maroccanus, Tachycines asynamorus, Oedaleus senegalensis, Zonozerus variegatus, Hieroglyphus daganensis, Kraussaria angulifera, Calliptamus italicus, Chortoicetes terminifera, Scudderia spp. (katydid) and Locustana pardalina,

Arachnoidea, such as arachnids ( Acarina ), e.g. of the families Argasidae, Ixodidae and Sarcoptidae, such as Amblyomma americanum, Amblyomma variegatum, Ambryomma maculatum, Argas persicus, Boophilus annulatus, Boophilus decoloratus, Boophilus microplus, Dermacentor silvarum, Dermacentor andersoni, Dermacentor variabilis, Hyalomma truncatum, Ixodes ricinus, Ixodes rubicundus, Ixodes scapularis, Ixodes holocyclus, Ixodes pacificus, Ornithodorus moubata, Ornithodorus hermsi, Ornithodorus turicata, Ornithonyssus bacoti, Otobius megnini, Dermanyssus gallinae, Psoroptes ovis, Rhipicephalus sanguineus, Rhipicephalus appendiculatus, Rhipicephalus evertsi, Sarcoptes scabiei, and Eriophyidae spp. such as Aculus schlechtendali, Phyl loco p tra ta o lei\ _>o ra (citrus rust mite), Aceria sheldoni (citrus bud mite)and Eriophyes sheldoni; Tarsonemidae spp. such as Phytonemus pallidus andPolyphagotarsonemus latus; Tenuipalpidae spp. such as Brevipalpus phoenicis; Tetranychidae spp. such as Tetranychus cinnabarinus, Tetranychus kanzawai, Tetranychuspacificus, Tetranychus telarius and Tetranychus urticae, Panonychus ulmi, Panonychuscitri( citrus red mite), and Oligonychus pratensis; Araneida, e.g. Latrodectus mactans, and Loxoscelesreclusa, fleas ( Siphonaptera ), e.g. Ctenocephalides felis, Ctenocephalides canis, Xenopsylla cheopis, Pulex irritans, Tunga penetrans, and Nosopsyllus fasciatus, silverfish, firebrat ( Thysanura ), e.g. Lepisma saccharina and Thermobia domestica,

centipedes ( Chilopoda ), e.g. Scutigera coleoptrata,

millipedes ( Diplopoda ), e.g. Narceus spp.,

earwigs ( Dermaptera ), e.g .forficula auricularia,

lice ( Phthiraptera ), e.g. Pediculus humanus capitis, Pediculus humanus corporis, Pthirus pubis, Haematopinus eurystemus, Haematopinus suis, Linognathus vituli, Bovicola bovis, Menopon gallinae, Menacanthus stramineus and Solenopotes capillatus, plant parasitic nematodes such as root-knot nematodes, Meloidogyne arenaria, Meloidogyne chitwoodi, Meloidogyne exigua, Meloidogyne hapla, Meloidogyne incognita, Meloidogyne javanica and other Meloidogyne species; cyst nematodes, Globodera rostochiensis, Globodera pallida, Globodera tabacum and other Globodera species, Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii, and other Heterodera species; seed gall nematodes, Anguina funesta, Anguina tritici and other Anguina species; stem and foliar nematodes, Aphelenchoides besseyi, Aphelenchoides fragariae, Aphelenchoides ritzemabosi and other Aphelenchoides species; sting nematodes, Belonolaimus longicaudatus and other Belonolaimus species; pine nematodes, Bursaphelenchus xylophilus and other Bursaphelenchus species; ring nematodes, Criconema species, Criconemella species, Criconemoides species, and Mesocriconema species; stem and bulb nematodes, Ditylenchus destructor, Ditylenchus dipsaci, Ditylenchus myceliophagus and other Ditylenchus species; awl nematodes, Dolichodorus species; spiral nematodes, Helicotylenchus dihystera, Helicotylenchus multicinctus and other Helicotylenchus species, Rotylenchus robustus and other Rotylenchus species; sheath nematodes, Hemicycliophora species and Hemicriconemoides species; Hirshmanniella species; lance nematodes, Hoplolaimus columbus, Hoplolaimus galeatus and other Hoplolaimus species; false root-knot nematodes, Nacobbus aberrans and other Nacobbus species; needle nematodes, Longidorus elongates and other Longidorus species; pin nematodes, Paratylenchus species; lesion nematodes, Pratylenchus brachyurus, Pratylenchus co feae, Pratylenchus curvitatus, Pratylenchus goodeyi, Pratylencus neglectus, Pratylenchus penetrans, Pratylenchus scribneri, Pratylenchus vulnus, Pratylenchus zeae and other Pratylenchus species; Radinaphelenchus cocophilus and other Radinaphelenchus species; burrowing nematodes, Radopholus similis and other Radopholus species; reniform nematodes, Rotylenchulus reniformis and other Rotylenchulus species; Scutellonema species; stubby root nematodes, Trichodorus primitivus and other Trichodorus species; Paratrichodorus minor and other Paratrichodorus species; stunt nematodes, Tylenchorhynchus claytoni, Tylenchorhynchus dubius and other Tylenchorhynchus species and Merlinius species; citrus nematodes, Tylenchulus semipenetrans and other Tylenchulus species; dagger nematodes, Xiphinema americanum, Xiphinema index, Xiphinema diversicaudatum and other Xiphinema species; and other plant parasitic nematode species.

In a preferred embodiment, the present invention provides a fungicidal or insecticidal combination/composition comprising of chlorantraniliprole, picoxystrobin and propiconazole to control the insect pests and mitesfrom the order of Lepidoptera, Coleoptera, Dipterajsopteraand Acarina.

The composition of the present invention used to control a wide variety of undesired pathogenic microorganisms, insect pests and mites, is advantageous, for several purposes, e.g.:

• useful for addressing a wider range of pest and diseases e.g. insecticidal, fungicidal and acaricidal activity;

• offering a single application as auniform composition in place of separate application of fungicides and insecticides; • offering crop health improvement in comparison to separate applications of fungicides and insecticides;

• longer residual control after application of the composition.

In another embodiment, the present invention providesa combination or composition that shows enhanced action against the undesired pathogenic microorganisms, insect pests and mites, in comparison to the control rates that are possible with the individual compounds and/or suitable for improving the health of plants when applied to plants, parts of plants, plant propagation materials, or at their locus of their growth.

In yet another embodiment, the combination or composition of the present invention is particularly important for controlling a multitude of undesired pathogenic microorganisms, insect pests and mites, on various cultivated plants or plant parts, such as cereals, e.g. wheat, rye, barley, triticale, oats, rice, mushroom; beet, e.g. sugar beet or fodder beet; fruits, such as pomes, stone fruits or soft fruits, e.g. apples, apricot, peanut, pears, pecan, plums, peaches, almonds, cherries, strawberries, raspberries, nectarine, prune, blackberries or gooseberries; leguminous plants, such as lentils, peas, alfalfa or soybeans; oil plants, such as oilseed rape, mustard, olives, sunflowers, coconut, cocoa beans, castor oil plants, oil palms, ground nuts or soybeans; cucurbits, such as squashes, cucumber or melons; fiber plants, such as cotton, flax, hemp or jute; citrus fruit, such as oranges, lemons, grapefruits or mandarins; vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, cucurbits or paprika; lauraceous plants, such as avocados, cinnamon or camphor; energy and raw material plants, such as corn, soybean, rape, sugar cane or oil palm; corn; tobacco; nuts; coffee; tea; bananas; vines (table grapes and grape juice grape vines); hop; turf; sweet leaf (also called Stevia); natural rubber plants or ornamental and forestry plants, such as flowers, shrubs, broad-leaved trees or evergreens, e.g. conifers; and on the plant propagation material, such as seeds, and the crop material of these plants.

In a preferred embodiment, the combination or composition of the present invention is particularly important for controlling a multitude of undesired pathogenic microorganisms, insect pests and mites, in the rice, tomato, chili, soybean and cucumber crop.

The rate of application amount varies depending on, for example, the blending ratio of an active ingredient, a metrological condition, a dosage form, an application time, an application method, an application place, a pest to be controlled, and a target crop, in ordinary cases. In the method of combating harmful fungi depending on the type of compound and the desired effect, the application rates of the mixtureaccording to the invention are preferably from 5 to 1000 g/ha, most preferably from 10 to 750 g/ha, in particular from 20 to 500 g/ha. In the method of combating pests (insects, acarids or nematodes) depending on the type of compound and the desired effect, the application rates of the mixture according to the invention are from , preferably from 20 to 1000 g/ha,more preferably from 10 to 750 g/ha, in particular from 20 to 500 g/ha. In an embodiment, the present invention provides a method for improving crop health (phyto-tonic effect), comprising treating a plant with an effective amount of composition of chlorantraniliprole, picoxystrobin and propiconazole.

The present invention is further illustrated by the following examples. These examples describe possible preferred embodiments for illustrative purposes only, but they do not limit the scope of the invention. These laboratory scale experiments can be scaled up to industrial/ commercial scale.

Example 1: Preparation of Suspension Concentrate (SC) Composition

Example 2: Preparation of SuspensionConcentrate (SC) Composition

Example 3: Preparation of Suspoemulsion (SE) Composition

Example 4: Preparation of Emulsion Concentrate (EC) Composition

Example 5: Preparation of Wettable powder (WP) Composition

Example 6: Preparation of Water dispersible Granules (WDG) Composition

Ingredients

Functions

Biological Examples:

Materials and methods

The trial was conducted at PI Industries Limited, Agricultural Research Station, Kashempeth, Telangana. A nursery of rice ( Oryza sativa L.) was raised and seedlings from the nursery were transplanted after 30 days of sowing at a spacing of 20cm x 15cm. All the recommended practices for rice cultivation were followed in this experiment. Twenty seven treatments were evaluated in a randomized complete block design with three replications (Plot size: 5m x 10m= 50 m²). Technical product of the insecticide chlorantraniliprole and of the fungicides picoxystrobin and propiconazole), were procured and used for application in different permutations and combinations. The applications of all the treatments were done 30 and 50 days after transplanting (DAT). Care was taken to avoid drift of spray solution to adjacent experimental plots. The applications were done with the help of a knapsack sprayer having a delivery of about 500 L/hectare of spray solution through a flat fan nozzle at a spray pressure of 20-25 psi.

Table 1: Treatment details to assess the synergistic effect of the combination of Chlorantraniliprole, Picoxystrobin and Propiconazole

Assessments of all the treatments were done for vigor, phytotoxicity and insect/ diseases control. Vigor descriptive scale was totally based on visual reflection. For vigor comparison among treatments, untreated plots were considered as 100 percent and based on that visual rating was given to other treatments. Phytotoxicity was recorded at 10 and 20 days after every application on 0-10 scale as shown in table 2. All plots were carefully observed for below mentioned phytotoxicity descriptive scale.

Table 2: Phytotoxicity descriptive scale (0-10)

Chlorantraniliprole is a ryanodine receptor modulator. Chlorantraniliprole activates ryanodine receptors of insects which stimulate the release of calcium from the internal stores of smooth and striated muscle, causing impaired muscle regulation, paralysis and ultimately insect death.

Picoxystrobin belongs to the strobilurin class, inhibits mitochondrial respiration, binds at the Qo on cytochrome b and block electron transfer between cytochrome b and cytochrome c; This disrupts the energy cycle within the fungus by halting production of ATP. Propiconazole acts on the fungal pathogen inside the plant at the stage of first haustoria formation; it stops the development of fungi by interfering with the biosynthesis of sterols in cell membranes and more precisely belongs to the group of DMI - fungicides (demethylation inhibitors). So combining all three compounds, each with a different mode of action, is a novel approach to address insect and diseases that appear simultaneously. Keeping this in mind the field trial was conducted to see the influence of this combination on pest control and crop yield.

For insect/ diseases control; observations were taken from ten tagged (randomly selected) hills from each plot starting from zero days of application onwards to 10 and 20 days interval after every applications for stem borer infestation (in the form of dead heart count), disease severity of sheath blight and leaf blast. Stem borer infestation was assessed by counting total tillers to the infested ones. The percent incidence that is dead hearts was calculated using the formula:

Number of dead hearts per hill

Dead heart incidence (%) = - x 100

Total number of tillers per hill

The observations on occurrence of sheath blight and leaf blast were recorded at 0, 10 and 20 days after every application by using 0-9 scale. Further, the scored data was converted into percent disease index (PDI) using formula given below.

Total sum of numerical ratings 100

PDI = X

Maximum disease rating Number of observations taken

Finally, at the time of rice harvesting, grain yield was recorded from net plot area; calculated into tons/hectare and compared among the treatments.

Establishment of synergistic action:

Surprisingly, the present experimental trial established evidence of a synergistic effect of the combination of chlorantraniliprole, picoxystrobin and propiconazole; showing effective control against rice stem borer, sheath blight andleaf blast when compared with their solo applications or two way mixtures.

Calculation of two way combination for expected activity with the Colby formula:

The expected activity for a given combination of two active compounds (binary composition) can be calculated as follows:

In which E represents the expected response for the combination of two pesticides at defined doses X= observed efficacy of active ingredient X at the same concentration as used in the mixture;

Y= observed efficacy of active ingredient Y at the same concentration as used in the mixture; When the observed response of the mixture is greater than the expected response (E) then the mixture is said to be synergistic.

Calculation of three way combination for expected activity with the Colby formula:

The expected action for the combination of three active ingredients can be calculated according to S. R. Colby (“Calculating Synergistic and Antagonistic Responses of Herbicide Combinations”, Weeds 1967, 15, 20-22), as follows:

(AB+AC+BC) ABC

Expected % weed control (E) = A+ B+ C - - 1 -

100 10000

A= observed efficacy of active ingredient A at the same concentration as used in the mixture;

B= observed efficacy of active ingredient B at the same concentration as used in the mixture;

C= observed efficacy of active ingredient C at the same concentration as used in the mixture.

Synergism of the mixture is determined by comparing observed response (O) of the mixture to the expected or predicted response (E) as calculated from the observed response of each individual component alone. If the observed response of the mixture is greater than the expected or predicted response (E) then the mixture is said to be synergistic. If E>0 then the result is antagonistic effect, If E=0 then its additional effect.

Results

Vigor and Phytotoxicity

Visual observation of the combination clearly indicated that all three active ingredients were physically compatible and safe to the rice crop. Picoxystrobin solo and in combination with propiconazole and chlorantraniliprole showed good plant vigor when compared to the control. Vigorous growth was observed in all the combination mixtures including picoxystrobin. The grain yield data also support the observed vigorous growth in the respective mixture treatments (Table 3). No Phytotoxicity symptoms were observed in any of the treatments in combination or as solo application.

Table 3: Vigor rating

Efficacy of chlorantraniliprole, picoxystrobin and propiconazole against sheath blight and leaf blast

There was no remarkable difference in disease incidence recorded with respect to sheath blight and 5 leaf blast in solo treatment of chlorantraniliprole. Binary mixture combination showed good prevention against these fungal diseases. Surprisingly, utmost prevention was recorded in the combination mixture of chlorantraniliprole, picoxystrobin and propiconazole, unexpectedly especially against Leaf Blast (Table 4 and 5).

Table 4: Efficacy of chlorantraniliprole, picoxystrobin and propiconazole against sheath blight

Figures in parenthesis are Percent disease control compared to control.

Table 5: Efficacy of Chlorantraniliprole, Picoxystrobin and Propiconazole against Leaf blast

Figures in parenthesis are Percent disease control compared to control.

Efficacy of chlorantraniliprole, picoxystrobin and propiconazole on stem borer control

Pre-treatment data indicated that the difference in the dead heart count per 10 tagged hills among the prepared plots for different treatments were almost uniform (Table 6). After 20 days of the second application, dead heart control was drastically improved in all treatments involving with chlorantraniliprole. Untreated plots recorded highest percentage of dead heart.

Table6: Efficacy of Chlorantraniliprole, Picoxystrobin and Propiconazole against Stem borer control.

Figures in parenthesis are stem borer damage control compared to control.

Efficacy of Chlorantraniliprole, Picoxystrobin and Propiconazole on grain yield

Data on grain yield revealed that treatment no. 25 (Chlorantraniliprole @ 40 + Picoxystrobin @ 80 & Propiconazole @ 120 gai/ha - 1 :2:3 ratio) recorded highest grain yield of 7.89 ton/ha followed by treatment no. 20 (Chlorantraniliprole @ 25 + Picoxystrobin @ 75 & Propiconazole @ 125 gai/ha - 1 :3:5 ratio ) 7.41 ton/ha respectively indicating synergism (Table 7). Table 7: Grain yield

Expected responses for the mixture are shown in above table following difference between observed and expected values are shown in the parenthesis by a plus (+) sign to indicate synergism. Conclusion

Severe crop damage and yield reduction is seen under field conditions when there is simultaneous attack of stem borer, sheath blight and leaf blast in rice. This is seen many times as the window of pest and disease attack overlaps in many rice growing countries across the globe. Surprisingly, a synergistic effect was seen in the combination comprising of Chlorantraniliprole, Picoxystrobin and Propiconazole in the ratios of 1:2:3 and 1:3:5 wherein pest and disease control was effective and synergies were observed in rice grain yield. Thus, from the foregoing description, it will be apparent to a person skilled in the art that many changes and modifications can be made thereto without departing from the spirit or scope of the invention as set forth in the description. Accordingly, it is not intended that the scope of the foregoing description is limited to the description set forth above, but rather that such description be construed as encompassing such features that reside in the present invention, including all the features and embodiments that would be treated as equivalents thereof by those skilled in the relevant art.

Claims

Claims:

1. A synergistic combination comprising of chlorantraniliprole, picoxystrobin and propiconazole or its acceptable salt(s) thereof, optionally, an addition of one or more insecticidal or fungicidal or acaricidal or nematicidal or herbicidal compounds or any combination thereof.

2. The synergistic combination as claimed in claim 1, wherein the ratio of chlorantraniliprole, picoxystrobin and propiconazole is from 1: 10: 20 to 1: 2: 3, more preferably 1: 5: 10 to 1: 2: 3, most preferably 1: 3: 5 to 1: 2: 3.

3. A synergistic composition comprising of chlorantraniliprole, picoxystrobin and propiconazole or its acceptable salt(s) thereof and agriculturally acceptable additives, optionally, an addition of one or more insecticidal or fungicidal or acaricidal or nematicidal or herbicidal compounds or any combination thereof.

4. The synergistic composition as claimed in claim 3, wherein the ratio of chlorantraniliprole, picoxystrobin and propiconazole is from 1: 10: 20 to 1: 2: 3, more preferably 1: 5: 10 to 1: 2: 3, most preferably 1: 3: 5 to 1: 2: 3.

5. The synergistic composition as claimed in claim 3, wherein active ingredeients chlorantraniliprole, picoxystrobin and propiconazole, having a particle size of 5 to 60 pm, more preferably 5 to 30 pm, most preferably 5 to 10 pm.

6. The synergistic composition as claimed in claim 3, wherein active ingredeients having a particle size (d50, determined after dispersion in the water phase by laser diffraction) of 5 to 40 pm, more preferably 5 to 30 pm, most preferably 5 to 10 pm.

7. The synergistic composition as claimed in claim 3, wherein agriculturally acceptable additives are is selected from the group comprising of solid carrier(s), liquid carrier(s), gaseous carrier(s), surfactant(s), binder(s), disintegrating agent(s), pH adjuster(s), thickener(s), preservative(s), anti-caking agent(s), anti-freezing agent(s), defoaming agent(s), extender(s), stabilizer (s) and/or coloring agent(s) or a combination thereof.

8. A method of application of the combination or composition as claimed in claim 1 or 3, for the management of the undesired insect pests or mites or pathogen.

9. The synergistic combination or composition as claimed in claims 1 or 3, wherein said combination or composition additionally comprises one or more compound selected from insecticide(s), fungicide(s), acaricide(s), nematicide(s), safener(s), herbicide(s) or any combination thereof.

10. The synergistic composition as claimed in claim 3, wherein said synergistic composition are selected from a wettable powder (WP), a water dispersible granule (WDG), a water dispersible tablet (WT), an ultra-low volume (ULV) liquid (UL), an ultra-low volume (ULV) suspension (SU), a water soluble powder (SP), a soluble concentrate (SL), a water soluble granule (SG), a suspo-emulsion (SE), granule (GR), an emulsifiable granule (EG), an oil-in- water emulsion (EW), an emulsifiable concentrate (EC), a micro-emulsion (ME), an oil dispersion (OD), a capsule suspension (CS), an aerosol (AE) or a mixed formulation of CS and SC (ZC).

11. The synergistic composition as claimed in claim 3, wherein said synergistic composition is a suspension concentrate (SC), suspo-emulsion (SE), emulsion concentrate (EC), wettable powder (WP) or a water dispersible granule (WDG).

12. A method for preparation of said composition as claimed in claim 9 comprising the steps of: a) addition of chlorantraniliprole, picoxystrobin and propiconazoleor its acceptable salt(s) thereof,

b) addition of agrochemically acceptable additives selected from surfactant(s), carrier(s) and other additive(s) uniformly in a mixer,

c) optionally milling by a mill.