WO2021016948A1 - 一种样本检测模块及样本分析仪 - Google Patents

一种样本检测模块及样本分析仪 Download PDF

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Publication number
WO2021016948A1
WO2021016948A1 PCT/CN2019/098710 CN2019098710W WO2021016948A1 WO 2021016948 A1 WO2021016948 A1 WO 2021016948A1 CN 2019098710 W CN2019098710 W CN 2019098710W WO 2021016948 A1 WO2021016948 A1 WO 2021016948A1
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WO
WIPO (PCT)
Prior art keywords
detection module
reaction cup
sample detection
reflective
electromagnetic coil
Prior art date
Application number
PCT/CN2019/098710
Other languages
English (en)
French (fr)
Inventor
孙骁
武振兴
郭文恒
Original Assignee
深圳迈瑞生物医疗电子股份有限公司
北京深迈瑞医疗电子技术研究院有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 深圳迈瑞生物医疗电子股份有限公司, 北京深迈瑞医疗电子技术研究院有限公司 filed Critical 深圳迈瑞生物医疗电子股份有限公司
Priority to PCT/CN2019/098710 priority Critical patent/WO2021016948A1/zh
Priority to CN201980097763.3A priority patent/CN113994209A/zh
Publication of WO2021016948A1 publication Critical patent/WO2021016948A1/zh

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Definitions

  • the invention relates to a medical analysis instrument, in particular to a sample detection module and a sample analyzer.
  • the detection of coagulation items by the coagulometer includes two methods: magnetic bead method and optical method.
  • the main principle of the magnetic bead method is to detect whether the coagulation reaction occurs by detecting the swing of the steel ball in the liquid to be tested under the drive of a magnetic field;
  • the optical method is to irradiate the plasma with light, and analyze the coagulation time by detecting scattered light or transmitted light .
  • the biggest pain point of optics is that compared with the magnetic bead method, it cannot avoid hemolysis, lipemia, jaundice and other colors from interfering with the sample.
  • the disadvantage of the magnetic bead method is that it also requires an optical sensor and needs to distinguish between optical test positions and magnetic bead test positions.
  • optical detection is currently performed above the magnetic bead coil, as shown in Figure 1. Two optical fibers 21 and 22 are set above the magnetic bead coil for transmitting and receiving respectively. This method The unified sensor can not only complete the optical method test, but also complete the magnetic bead method test.
  • the biggest problem is that the drive coils 11 and 12 need to be coaxial with the magnetic bead at the bottom axis of the cuvette. Therefore, in terms of structure, the optical fiber optical path needs to avoid the magnetic bead drive coil. Compared with the method sensor, it needs more liquid to ensure that the optical path is completely in the liquid, so each optical item test requires more reagents, which increases the cost.
  • the embodiment of the present invention is expected to provide a sample detection module and sample analyzer that can perform both the optical method test and the magnetic bead method test at the same time, and for the optical item test, the amount of sample liquid used is equal to
  • the simple optical method sample detection module and the sample liquid volume used by the analyzer are basically the same, which can save reagents and reduce costs.
  • the embodiment of the present invention provides a sample detection module, including an irradiation mechanism, a first reflecting part, a second reflecting part, a first electromagnetic coil, a second electromagnetic coil, and a light receiving mechanism;
  • the first electromagnetic coil and the second electromagnetic coil are oppositely arranged on both sides of the reaction cup; and there is a gap between the first electromagnetic coil and the second electromagnetic coil and the reaction cup;
  • the first reflective part is provided in the gap between the first electromagnetic coil and the reaction cup, and the second reflective part is provided in the gap between the second electromagnetic coil and the reaction cup;
  • the illumination mechanism at least includes a light source
  • the light receiving mechanism at least includes a detector
  • the light beam emitted by the light source is reflected into the reaction cup by the first reflective part, and passes through the reaction cup and is reflected to the detector by the second reflective part.
  • the light source and the first reflective part are arranged in sequence along a direction parallel to the axis of the cuvette; or, the light source and the first reflective part are arranged in sequence along a direction perpendicular to the axis of the cuvette.
  • the detector and the second reflective part are arranged in sequence along a direction parallel to the axis of the cuvette; or, the detector and the second reflective part are arranged in sequence along a direction perpendicular to the axis of the cuvette.
  • the irradiating mechanism further includes a transmitting optical fiber, the transmitting optical fiber is arranged between the light source and the first reflecting part, and receives and transmits the light emitted by the light source.
  • the irradiation mechanism further includes a collimator, which processes the light beam emitted by the light source to propagate to the first reflective component in a set direction.
  • the light receiving mechanism further includes a coupler, which processes the light beam reflected by the second reflective part to propagate in a set direction.
  • the light receiving mechanism further includes a receiving optical fiber, which receives the light beam reflected by the second reflecting part and transmits it to the detector.
  • the light receiving mechanism further includes a receiving fiber, which receives the reflected light beam processed by the coupler and transmits it to the detector.
  • the light source, the collimator and the first reflecting part are arranged in sequence along a direction parallel to the axis of the reaction cup; or, the light source, the collimator and the first reflecting part are arranged in order along a direction perpendicular to the axis of the reaction cup. Set up.
  • the second reflective part, the coupler and the detector are arranged in sequence along a direction parallel to the axis of the cuvette; or, the second reflective part, the coupler and the detector are sequentially arranged along a direction perpendicular to the axis of the cuvette.
  • the first reflective component includes a first reflective surface
  • the second reflective component includes a second reflective surface
  • the light beam emitted by the light source is processed by the collimator to interact with the first reflective surface.
  • a reflecting surface is incident at an angle of 45 degrees, and then reflected by the first reflecting surface in a direction perpendicular to the side wall of the cuvette, and penetrates perpendicularly from the side wall of the opposite side of the cuvette.
  • the second reflecting surface is incident at an angle of 45 degrees, and then is reflected to the coupler, processed by the coupler, and transmitted to the detector.
  • the light source, the emitting fiber, the collimator and the first reflecting part are arranged in order along a direction parallel to the axis of the reaction cup; or the light source, the emitting fiber, the collimator and the first reflecting part are arranged along the same
  • the axis of the reaction cup is arranged in the vertical direction.
  • the second reflecting part, the coupler, the receiving fiber and the detector are arranged in sequence along a direction parallel to the axis of the reaction cup; or, the second reflecting part, the coupler, the receiving fiber and the detector are arranged along with The axis of the reaction cup is arranged in the vertical direction.
  • the first reflecting part includes a first reflecting surface
  • the second reflecting part includes a second reflecting surface
  • the light beam transmitted by the transmitting fiber is processed by the collimator to interact with the
  • the first reflecting surface is incident at an angle of 45 degrees, and then reflected by the first reflecting surface in a direction perpendicular to the side wall of the cuvette, and perpendicularly exits from the side wall of the opposite side of the cuvette.
  • the second reflecting surface is incident at an angle of 45 degrees, and then is reflected to the coupler, is received by the receiving fiber after being processed by the coupler, and is transmitted to the detector.
  • the irradiation mechanism further includes a collimator and a third reflecting part; the collimator processes the light beam emitted by the light source to propagate to the third reflecting part in a set direction, The third reflecting part is reflected to the first reflecting part, is reflected by the first reflecting part into the reaction cup, and passes through the reaction cup to the second reflecting part.
  • the light receiving mechanism further includes a coupler and a fourth reflecting part; the light beam is reflected to the fourth reflecting part by the second reflecting part, and is reflected to the fourth reflecting part by the fourth reflecting part.
  • the coupler is processed by the coupler and transferred to the detector.
  • the light source, the collimator and the third reflective part are arranged in sequence along a direction parallel to the first electromagnetic coil.
  • the fourth reflective component, the coupler and the detector are arranged in sequence along a direction parallel to the second electromagnetic coil.
  • first electromagnetic coil and the second electromagnetic coil are arranged so that their axes coincide; the first reflecting part and the second reflecting part are arranged so that the propagation light path between them lies on the axis Above, or substantially coincide with the axis.
  • first reflective part and the second reflective part are flat mirrors or non-planar mirrors.
  • the transmitting optical fiber and the receiving optical fiber are both 1-division multi-optical fibers or single optical fibers.
  • magnetic beads are arranged in the reaction cup.
  • An embodiment of the present invention also provides a sample analyzer, which includes a housing and the sample detection module described in any of the above embodiments, and the sample detection module is disposed in the housing.
  • a first reflection part is provided in the gap between the first electromagnetic coil and the reaction cup, and a second reflection part is provided in the gap between the second electromagnetic coil and the reaction cup.
  • Components; the light beam emitted by the light source is reflected by the first reflective part into the reaction cup, and passes through the reaction cup and is reflected to the detector by the second reflective part.
  • the first reflection part and the second reflection part are arranged at the above positions to realize the turning of the detection light path, reduce the amount of sample liquid used for optical item testing, and save reagents. Reduce the cost of testing.
  • FIG. 1 Schematic diagram of the prior art scheme
  • Figure 2 is a front view of a sample detection module in an embodiment
  • Figure 3 is a front view of a sample detection module in another embodiment
  • Figure 4 is a front view of a sample detection module in another embodiment
  • Figure 5 is a front view of a sample detection module in another embodiment
  • Fig. 6 is a front view of the sample detection module in another embodiment.
  • the embodiment of the present invention provides a sample detection module and a sample analyzer capable of simultaneously completing the optical method test and the magnetic bead method test; by improving the structure, especially the design and layout of the optical detection components, by performing the optical path
  • the turning point is to reduce the amount of sample liquid used in the test, save reagents, and reduce test costs.
  • the sample detection module and the sample analyzer can be used to test the coagulation time of the blood sample, the sample detection module is a coagulation analysis module, and the sample analyzer is a coagulation analyzer.
  • a sample detection module provided by an embodiment of the present invention includes an irradiation mechanism 5, a first reflective part 31, a second reflective part 32, a first electromagnetic coil 11, a second electromagnetic coil 12, and a light receiving device. Institution 7. Wherein, the first electromagnetic coil 11 and the second electromagnetic coil 12 are oppositely arranged on both sides of the reaction cup 6, and there is a gap between the first electromagnetic coil 11 and the second electromagnetic coil 12 and the reaction cup 6.
  • the first reflective member 31 is provided in the gap between the first electromagnetic coil 11 and the cuvette 6, and the gap between the second electromagnetic coil 12 and the cuvette 6 is provided The second reflective member 32.
  • the irradiation mechanism 5 includes at least a light source, and the light source generates a light beam for testing.
  • the light receiving mechanism 7 includes a detector.
  • the light beam emitted by the light source is reflected by the first reflective part 31 into the cuvette 6, passes through the cuvette 6 to the second reflective part 32 on the opposite side, and is reflected by the second reflective part 32 to the detector.
  • the sample detection module in the above embodiment pulls the first electromagnetic coil and the second electromagnetic coil to the outer sides of the reaction cup a smaller distance, such as: 2 ⁇ 5mm (traditional magnetic bead).
  • the electromagnetic coil of the sensor is close to the side wall of the reaction cup), so as not to affect the effect of the magnetic field on the magnetic beads.
  • Figure 2 shows the axis of the reaction cup; in the following examples, the direction from the bottom of the reaction cup to the opening is from bottom to top, and vice versa is from top to bottom; when facing Figure 2, the vertical paper surface is from outside to inside , That is, along the direction perpendicular to the axis of the reaction cup, from the outside to the inside; when facing Figure 2-6, the left hand side is the left side, and the right hand side is the right side.
  • the irradiating mechanism 5 and the first reflecting member 31 are arranged in sequence along a direction parallel to the axis of the cuvette 6.
  • the irradiating mechanism includes at least a light source (not shown in the figure), and the light source and the first reflecting part are arranged in sequence along a direction parallel to the axis of the reaction cup.
  • the light source and the first reflecting part can be arranged in order from bottom to top along the direction parallel to the axis of the reaction cup, or arranged in order from top to bottom (taking the reaction cup as a reference, the direction from the bottom of the reaction cup to the opening, that is, from bottom to top) Direction).
  • the irradiating mechanism 5 and the first reflecting member 31 are sequentially arranged along a direction perpendicular to the axis of the cuvette 6.
  • the light source and the first reflecting part are arranged in sequence along the direction perpendicular to the axis of the reaction cup.
  • the light source and the first reflecting part can be arranged in order from the inside to the outside along the direction perpendicular to the axis of the cuvette, or they can be arranged in order from the outside to the inside (when facing Fig. 2, the vertical paper surface is from outside to inside, or from inside to outside).
  • the second reflecting member 32 and the light receiving mechanism 7 are arranged in order along the direction parallel to the axis of the cuvette 6.
  • the light receiving mechanism at least includes a detector, and the second reflecting part and the detector are arranged in sequence along a direction parallel to the axis of the reaction cup.
  • the second reflecting part and the detector can be arranged in order from bottom to top along the direction parallel to the axis of the reaction cup, or arranged in order from top to bottom.
  • the second reflective component 32 and the light receiving mechanism 7 are arranged in sequence along a direction perpendicular to the axis of the cuvette 6.
  • the second reflective component and the detector are arranged in sequence along the direction parallel to the axis of the reaction cup.
  • the second reflective part and the detector can be arranged in order from the inside to the outside along the direction perpendicular to the axis of the reaction cup, or can be arranged in order from the outside to the inside.
  • the irradiation mechanism 5 further includes a collimator 41, which collimates the light beam.
  • the collimator can be a single lens or a group of lenses.
  • the collimator may not be provided, which is mainly determined by the requirements of the light source, optical fiber, parameters, and detection module.
  • the light source, the collimator 41, and the first reflecting part 31 are arranged in sequence along a direction parallel to the axis of the cuvette 6, if they can be arranged in this direction from bottom to top, or from top to bottom.
  • the light source, the collimator 41 and the first reflecting member 31 are arranged in sequence along a direction perpendicular to the axis of the cuvette 6, such as being arranged in this direction from the inside to the outside, or from the outside to the inside.
  • the irradiating mechanism further includes a transmitting fiber 21, which is arranged between the light source and the first reflecting part 31, and receives and transmits the light emitted by the light source.
  • the launch fiber can be a 1-point multi-fiber or a single fiber.
  • a light source may be directly used instead of the transmitting fiber, which can be selected according to actual needs.
  • the light source, the emitting fiber 21, the collimator 41, and the first reflecting member 31 are arranged in sequence along the direction parallel to the axis of the cuvette 6, such as from bottom to top in this direction, or from top to bottom. Set in order.
  • the light source, the emitting fiber 21, the collimator 41, and the first reflecting member 31 are arranged in order along the direction perpendicular to the axis of the cuvette 6.
  • they can be arranged in order from the inside to the outside along this direction, or from the outside to the inside. Set up.
  • the light receiving mechanism 7 further includes a coupler 42, which collimates the light beam.
  • the coupler can be a single lens or a group of lenses.
  • the coupler may not be provided, which is mainly determined by the light source, optical fiber, parameters, and detection module requirements.
  • the second reflective component 32, the coupler 42, and the detector are arranged in sequence along the direction parallel to the axis of the cuvette 6, if they can be arranged in this direction from bottom to top, or by Set up in order from top to bottom.
  • the second reflective component 32, the coupler 42, and the detector are arranged in order along a direction perpendicular to the axis of the cuvette.
  • they can be arranged in order from the inside to the outside along this direction, or they can be arranged in order from the outside to the inside.
  • the light receiving mechanism 7 further includes a receiving optical fiber 22, which receives the light beam reflected by the second reflecting part 32 and transmits it to the detector.
  • the receiving optical fiber can be a 1-point multi-optical fiber or a single optical fiber.
  • the receiving fiber may not be used, and a detector (such as a PD detector) may be used directly, which can be selected as required.
  • the second reflective component 32, the coupler 42, the receiving fiber 22, and the detector are arranged in order along the direction parallel to the axis of the cuvette 6, for example, they can be arranged in this direction from bottom to top, or from top to bottom. Set in sequence (from bottom to top, please refer to the previous embodiment).
  • the second reflecting part 32, the coupler 42, the receiving fiber 22, and the detector are arranged in order along the direction perpendicular to the axis of the cuvette 6.
  • the second reflecting part 32, the coupler 42, the receiving fiber 22, and the detector may be arranged in order from the inside to the outside, or from the outside to the inside. Set up.
  • the arrangement of the components of the irradiation mechanism and the arrangement of the components of the optical fiber receiving mechanism can be arbitrarily combined as needed.
  • the components of the irradiation mechanism are arranged in order from bottom to top along the direction parallel to the axis of the cuvette, and The components of the optical fiber receiving mechanism can be arranged sequentially from top to bottom along the direction parallel to the axis of the reaction cup.
  • the light source, the emitting fiber 21, the collimator 41, and the first reflecting member 31 are arranged in order from bottom to top along the direction parallel to the axis of the cuvette 6.
  • the second reflective component 32, the coupler 42, the receiving optical fiber 22 and the detector are arranged in order from top to bottom along the direction parallel to the axis of the reaction cup 6.
  • the first reflective component 31 includes a first reflective surface 311
  • the second reflective component 32 includes a second reflective surface 322.
  • the light beam emitted by the light source is transmitted to the collimator 41 through the emission fiber 21, and then enters the first reflecting surface 311 at an angle of 45 degrees, and then is reflected by the first reflecting surface 311 to be perpendicular to the cuvette 6 Inject in the direction of the side wall and exit from the opposite side of the reaction cup 6 to the vertical side wall.
  • the light beam that passes out enters the second reflecting surface 322 at an angle of 45 degrees, and then is reflected to the coupler 42. After being processed by the coupler 42, it is received by the receiving optical fiber 22 and passed to the detector.
  • the transmitting fiber 21 and the receiving fiber 22 can be optional according to requirements, and can be omitted in some cases.
  • the first reflecting part 31 when the light beam reflected by the first reflecting part 31 enters the cuvette 6 vertically, the light beam passes through the cuvette 6 and then enters the second reflecting part 32. Even if the light path passes through the cuvette horizontally, the first can be adjusted appropriately.
  • the relative position and angle between the reflecting part and the irradiating mechanism can also make the reflected light beam perpendicularly inject into the reaction cup, and the above effect can also be achieved.
  • the relative position and angle between the second reflective part and the light receiving mechanism can also be adjusted so that the light beam passing through the reaction cup can be received by the light receiving mechanism after being reflected by the second reflective part.
  • the light source (not shown in the figure), the emitting fiber 21, the collimator 41 and the first reflecting part 31 are arranged in order from top to bottom along the direction parallel to the axis of the reaction cup 6.
  • the second reflecting component 32, the coupler 42, the receiving fiber 22 and the detector (not shown in the figure) are arranged in order from bottom to top along the direction parallel to the axis of the reaction cup 6.
  • the irradiating mechanism may further include a third reflecting part 33; the light beam emitted by the light source is transmitted to the collimator 41 through the emission fiber 21 for collimation, and is transmitted to the third reflecting part.
  • the component 33 is reflected to the first reflective component 31 by the third reflective component 33, is reflected by the first reflective component 31 into the cuvette 6, and passes through the cuvette 6 to be directed toward the second reflective component 32.
  • the light receiving mechanism may further include a fourth reflecting part 34; the light beam is reflected by the second reflecting part 32 to the fourth reflecting part 34, and is reflected by the fourth reflecting part 34 to the coupler 42 for collimation Then, the light beam is transferred to the receiving fiber 22 and then to the detector.
  • the transmitting fiber, the receiving fiber, the collimator, and the coupler are all optional according to needs, that is, one or more of them can be selected to be used or not used or used.
  • the light source, the transmitting fiber 21, the collimator 41, and the third reflecting member 33 are arranged in order from left to right along the direction parallel to the first electromagnetic coil 11, and can be arranged on the first electromagnetic coil 11 Below (or above).
  • the fourth reflecting part 34, the coupler 42, the receiving optical fiber 22 and the detector are arranged in order from left to right along the direction parallel to the second electromagnetic coil 12, and may be arranged under the second electromagnetic coil (or Above).
  • the first reflective component 31 includes a first reflective surface 311
  • the second reflective component 32 includes a second reflective surface 321
  • the third reflective component 33 includes a third reflective surface 33
  • the fourth reflective component 34 includes a fourth reflective surface 341.
  • the light beam emitted by the light source is transmitted to the collimator 41 through the emission fiber 21 for processing, is incident on the third reflecting surface 331 at an angle of 45 degrees, and then is reflected by the third reflecting surface 331 to interact with the
  • the first reflecting surface 311 is incident at an angle of 45 degrees.
  • the light beam reflected by the first reflecting surface 311 is incident in the direction perpendicular to the side wall of the cuvette 6, and passes through the opposite side of the cuvette 6.
  • the outgoing light beam is incident at an angle of 45 degrees with the second reflecting surface 321, and then reflected by the second reflecting surface 321 to incident at an angle of 45 degrees with the fourth reflecting surface 341, and then reflected to the coupler 42. After being processed by the coupler 42, it is received by the receiving optical fiber 22 and passed to the detector (not shown in the figure).
  • the light source, the emitting fiber, the collimator and the third reflecting part can be arranged in sequence along the direction perpendicular to the axis of the cuvette.
  • the fourth reflecting part, the coupler, the receiving fiber and the detector can be arranged in sequence along the direction perpendicular to the axis of the reaction cup, for example, they can be arranged in sequence from the outside to the inside, or they can be arranged in order from the inside to the outside.
  • the specific settings of the components of the irradiation mechanism and the specific settings of the components of the light receiving mechanism are not limited to the listed embodiments, and can be set and adjusted according to actual needs.
  • the light beam reflected by the first reflecting part enters the cuvette vertically
  • the light beam enters the second reflecting part after passing through the cuvette.
  • the first light beam can be adjusted appropriately.
  • the relative position and angle between the reflecting part and the irradiating mechanism can also make the reflected light beam perpendicularly inject into the reaction cup, and the above effect can also be achieved.
  • the relative position and angle between the second reflective part and the light receiving mechanism can also be adjusted so that the light beam passing through the reaction cup can be received by the light receiving mechanism after being reflected by the second reflective part.
  • the first reflective part and the second reflective part are mirrors, or right-angle prisms, and the mirrors can be flat mirrors or non-planar mirrors (such as mirrors with curvature).
  • the non-planar mirror may be a spherical mirror.
  • the non-planar mirror can play the role of collimation, so there is no need to provide a collimator.
  • the first spherical mirror includes a first spherical reflective surface 351 and a first spherical reflective bottom surface 352 and the second spherical reflective mirror includes a second spherical reflective surface 361 and a second spherical reflective bottom surface 362.
  • the first spherical reflective bottom surface 352 and the cuvette 6 are arranged at an angle of 45 degrees, and the emitting fiber 21 makes the light beam emitted from the light source incident at a 45 degree angle to the first spherical reflective bottom surface 352, and then passes through the first spherical reflective surface 351
  • the reflection enters in the direction perpendicular to the side wall of the cuvette 6, and passes through the opposite side of the cuvette 6 perpendicular to the side wall, that is, the light beam passes through the cuvette horizontally, and the light beam that passes out reflects the bottom surface 362 of the second spherical surface. It is incident at an angle of 45 degrees, and then reflected to the receiving optical fiber 22 by the second spherical reflecting surface 361.
  • both the transmitting fiber and the receiving fiber are optional according to needs.
  • the angle between the first spherical reflective bottom surface and the reaction cup, and the angle between the second spherical reflective bottom surface and the reaction cup can be adjusted according to detection requirements.
  • Corresponding other optical components such as light source, transmitting fiber, receiving fiber and detector can also be adjusted in position and angle.
  • the light path can be turned twice by four reflecting mirrors, or the light path can be turned once by two reflecting mirrors. But it is not limited to this.
  • the detection of magnetic bead items and optical items can be completed at the same time while reducing the amount of sample liquid, achieving the effect of saving reagents.
  • Other solutions are also protected by this application. Within range.
  • the first electromagnetic coil and the second electromagnetic coil are arranged so that their axes coincide.
  • the first reflecting part and the second reflecting part are arranged so that the propagation light path between them is above the axis or substantially coincides with the axis.
  • the detection light path passes through the side wall of the cuvette, avoiding the arc position at the bottom of the cuvette, and can reduce the amount of sample liquid.
  • the reaction cup can choose to add magnetic beads, not add magnetic beads, or take out magnetic beads.
  • the magnetic ball is a steel ball.
  • the reaction cup when performing the four-phase magnetic bead detection of blood coagulation, add steel balls to the reaction cup to perform normal four-phase coagulation detection; when performing optical detection, remove the steel ball, as shown in Figure 6, because the steel ball is removed and passed through The detection light path of the reaction cup can be further reduced, thereby further reducing the total detection liquid volume.
  • An embodiment of the present invention also provides a sample analyzer, which includes a housing and the sample detection module described in any of the above embodiments, and the sample detection module is disposed in the housing.
  • the sample analyzer is a blood coagulation analyzer, which can simultaneously complete the detection of the magnetic bead item and the optical item.
  • the optical item's sample liquid volume is reduced through the turning of the optical path and reagents are saved.

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Abstract

一种样本检测模块及分析仪，包括照射机构(5)、第一反射部件(31)、第二反射部件(32)、第一电磁线圈(11)、第二电磁线圈(12)和光线接收机构(7)。第一电磁线圈(11)和第二电磁线圈(12)相对设置在反应杯(6)的两侧，且第一电磁线圈(11)和第二电磁线圈(12)与反应杯(6)之间均具有间隙。在第一电磁线圈(11)和反应杯(6)之间的间隙设有第一反射部件(31)，在第二电磁线圈(12)和反应杯(6)之间的间隙设有第二反射部件(32)。照射机构(5)发出的光束由第一反射部件(31)反射入反应杯(6)，并穿过反应杯(6)由第二反射部件(32)反射给光线接收机构(7)。

Description

一种样本检测模块及样本分析仪 技术领域
本发明涉及一种医用分析仪器，尤其涉及一种样本检测模块及样本分析仪。
 背景技术
目前血凝仪对凝血项目的检测包括两种方法：磁珠法和光学法。磁珠法的主要原理是通过检测在待测液体中钢珠在磁场驱动下的摆动，来检测是否发生凝固反应；光学法是通过用光照射血浆，并通过检测散射光或透射光分析得到凝血时间。
 技术问题
光学的最大痛点在于和磁珠法相比其终究无法避免溶血、脂血、黄疸等颜色干扰样本。但由于对于D-二聚体、FDP、AT3等项目只能采用光学法测试，故磁珠法的劣势在于也需要光学传感器，且需要区分光学测试位和磁珠测试位。为了解决磁珠法的该问题，目前会在磁珠线圈的上方进行光学检测，具体如图1，在磁珠线圈上方设置两根光纤21和22，分别用于发射和接收，通过这样的方法使得统一传感器既能完成光学法测试，也能完成磁珠法测试。但其最大问题在于，驱动线圈11和12需与磁珠在反应杯的底部轴线同轴 ，故结构上，光纤光路需要在上方避让开磁珠驱动线圈，这样做光学法项目时，与单一光学法传感器相比，需要更多的液体以保证光路完全在液体中，故每一个光学项目的测试都需要更多的试剂，增加了成本。
 技术解决方案
为了解决上述技术中存在的不足，本发明实施例期望提供一种既能同时完成光学法测试和磁珠法测试的样本检测模块及样本分析仪，且对于光学项目测试时，所用样本液量与单纯光学法样本检测模块及分析仪所用样本液量相比基本一致，进而可节省试剂，并降低成本。
本发明实施例提供一种样本检测模块，包括照射机构、第一反射部件、第二反射部件、第一电磁线圈、第二电磁线圈和光线接收机构；
所述第一电磁线圈和第二电磁线圈相对设置在反应杯的两侧；且所述第一电磁线圈和第二电磁线圈与所述反应杯之间均具有间隙；
在所述第一电磁线圈和所述反应杯之间的间隙设有所述第一反射部件，在所述第二电磁线圈和所述反应杯之间的间隙设有所述第二反射部件；
所述照射机构至少包括光源；
所述光线接收机构至少包括探测器；
所述光源发出的光束由第一反射部件反射入反应杯，并穿过反应杯由第二反射部件反射给所述探测器。
一个实施例中，所述光源和第一反射部件沿与反应杯轴线平行方向依次设置；或者，所述光源和第一反射部件沿与反应杯轴线垂直方向依次设置。
另一实施例中，所述探测器和第二反射部件沿与反应杯轴线平行方向依次设置；或者，所述探测器和第二反射部件沿与反应杯轴线垂直方向依次设置。
另一实施例中，所述照射机构还包括发射光纤，所述发射光纤设置在所述光源和第一反射部件之间，接收所述光源发出的光并进行传递。
另一实施例中，所述照射机构还包括准直器，处理所述光源发出的光束使其按照设定的方向传播给所述第一反射部件。
另一实施例中，所述光线接收机构还包括耦合器，处理第二反射部件反射的光束使其按照设定的方向传播。
另一实施例中，所述光线接收机构还包括接收光纤，接收第二反射部件反射的光束并传递给所述探测器。
另一实施例中，所述光线接收机构还包括接收光纤，接收经过所述耦合器处理的反射光束并传递给所述探测器。
另一实施例中，所述光源、准直器和第一反射部件沿与反应杯轴线平行方向依次设置；或者，所述光源、准直器和第一反射部件沿与反应杯轴线垂直方向依次设置。
另一实施例中，所述第二反射部件、耦合器和探测器沿与反应杯轴线平行方向依次设置；或者，所述第二反射部件、耦合器和探测器沿与反应杯轴线垂直方向依次设置。
另一实施例中，所述第一反射部件包括第一反射面，所述第二反射部件包括第二反射面；所述光源发出的光束经过所述准直器处理后，以与所述第一反射面呈45度夹角方向入射，然后经第一反射面反射以垂直反应杯侧壁方向射入，并从反应杯相对面的侧壁垂直穿出，所述穿出的光束以与所述第二反射面呈45度夹角方向入射，然后反射给所述耦合器，经耦合器处理后传递给所述探测器。
另一实施例中，所述光源、发射光纤、准直器和第一反射部件沿与反应杯轴线平行方向依次设置；或者，所述光源、发射光纤、准直器和第一反射部件沿与反应杯轴线垂直方向依次设置。
另一实施例中，所述第二反射部件、耦合器、接收光纤和探测器沿与反应杯轴线平行方向依次设置；或者，所述第二反射部件、耦合器、接收光纤和探测器沿与反应杯轴线垂直方向依次设置。
另一实施例中，所述第一反射部件包括第一反射面，所述第二反射部件包括第二反射面；所述发射光纤传递的光束经过所述准直器处理后，以与所述第一反射面呈45度夹角方向入射，然后经第一反射面反射以垂直反应杯侧壁方向射入，并从反应杯相对面的侧壁垂直穿出，所述穿出的光束以与所述第二反射面呈45度夹角方向入射，然后反射给所述耦合器，经耦合器处理后被接收光纤接收，并传递给所述探测器。
另一实施例中，所述照射机构还包括准直器和第三反射部件；所述准直器，处理所述光源发出的光束使其按照设定的方向传播给所述第三反射部件，经所述第三反射部件反射给第一反射部件，由第一反射部件反射入反应杯，并穿过反应杯射给第二反射部件。
另一实施例中，所述光线接收机构还包括耦合器和第四反射部件；所述光束经所述第二反射部件反射给所述第四反射部件，并由所述第四反射部件反射给所述耦合器，经所述耦合器处理后传递给所述探测器。
另一实施例中，所述光源、准直器和第三反射部件沿与所述第一电磁线圈平行方向依次设置。
另一实施例中，所述第四反射部件、耦合器和探测器沿与所述第二电磁线圈平行方向依次设置。
另一实施例中，设置所述第一电磁线圈和第二电磁线圈，使两者的轴线重合；设置所述第一反射部件和第二反射部件，使其之间的传播光路在所述轴线之上，或与所述轴线基本重合。
另一实施例中，所述第一反射部件和第二反射部件为平面反射镜或非平面反射镜。
另一实施例中，所述发射光纤和接收光纤均为1分多光纤或单根光纤。
另一实施例中，所述反应杯内设有磁珠。
本发明实施例还提供一种样本分析仪，包括壳体、以及上述任一实施例所述的样本检测模块，所述样本检测模块设置在所述壳体内。
 有益效果
本发明实施例提供的样本检测模块及样本分析仪，在第一电磁线圈和反应杯之间的间隙设有第一反射部件，在第二电磁线圈和反应杯之间的间隙设有第二反射部件；光源发出的光束由第一反射部件反射入反应杯，并穿过反应杯由第二反射部件反射给探测器。本发明实施例提供的样本检测模块及样本分析仪，通过在上述位置设置第一反射部件和第二反射部件实现了对检测光路的转折，减少了光学项目测试所用样本液量，节省了试剂，降低了检测成本。
 附图说明
图1现有技术方案示意图；
图2一个实施例中样本检测模块的主视图；
图3另一个实施例中样本检测模块的主视图；
图4另一个实施例中样本检测模块的主视图；
图5另一个实施例中样本检测模块的主视图；
图6另一个实施例中样本检测模块的主视图。
 本发明的实施方式
为了能够更加详尽地了解本发明实施例的特点与技术内容，下面结合附图对本发明实施例的实现进行详细阐述，所附附图仅供参考说明之用，并非用来限定本发明。
本发明实施例提供一种能同时完成光学法测试和磁珠法测试的样本检测模块及样本分析仪；通过对其结构进行改进，尤其是对光学检测各部件的设计和布局，通过对光路进行转折，减少测试时所用样本液量，节省试剂，降低测试成本。其中，所述样本检测模块及样本分析仪可用于对血液样本的凝血时间进行测试，所述样本检测模块为凝血分析模块，所述样本分析仪为凝血分析仪。
可参考图2所示，本发明实施例提供的一种样本检测模块，包括照射机构5、第一反射部件31、第二反射部件32、第一电磁线圈11、第二电磁线圈12和光线接收机构7。其中，第一电磁线圈11和第二电磁线圈12相对设置在反应杯6的两侧，且第一电磁线圈11和第二电磁线圈12与反应杯6之间均具有间隙。在所述第一电磁线圈11和所述反应杯6之间的间隙设有所述第一反射部件31，在所述第二电磁线圈12和所述反应杯6之间的间隙设有所述第二反射部件32。其中，所述照射机构5至少包括光源，光源产生光束用于测试。所述光线接收机构7包括探测器。所述光源发出的光束由第一反射部件31反射入反应杯6，并穿过反应杯6传递到相对侧的第二反射部件32，并由第二反射部件32反射给所述探测器。
与传统磁珠法传感器相比，上述实施例中的样本检测模块，将第一电磁线圈、第二电磁线圈向反应杯外两侧拉开较小的距离，如：2~5mm(传统磁珠法传感器的电磁线圈紧贴反应杯侧壁),尽量不影响磁场对磁珠的作用。但若考虑，电磁线圈拉开一定距离后，可能会对磁珠摆动有影响，可以依靠如增加电磁线圈铁芯的直径，或改变铁芯材料进行补偿，达到和传统磁珠法传感器类似或更好的效果。
如图2所示为反应杯轴线；以下实施例中，反应杯底部到开口的方向，为由下至上的方向，反之为由上至下的方向；面向图2时，垂直纸面由外向内，即为沿与反应杯轴线垂直方向，由外向内；面向图2-6时，左手一侧为左侧，右手一侧为右侧。
在一个实施例中，照射机构5和第一反射部件31沿与反应杯6轴线平行方向依次设置。照射机构至少包括光源（图中未示出），光源和第一反射部件沿与反应杯轴线平行方向依次设置。其中，光源和第一反射部件既可沿与反应杯轴线平行方向，由下至上依次设置，也可由上至下依次设置（以反应杯为参考，反应杯底部到开口的方向，即由下至上的方向）。
在另一实施例中，照射机构5和第一反射部件31沿与反应杯6轴线垂直方向依次设置。此时，光源和第一反射部件沿与反应杯轴线垂直方向依次设置。其中，光源和第一反射部件既可沿与反应杯轴线垂直方向，由内向外依次设置，也可由外向内依次设置（面向图2时，垂直纸面由外向内，或由内向外）。
在另一实施例中，第二反射部件32和光线接收机构7沿与反应杯6轴线平行方向依次设置。光线接收机构至少包括探测器，第二反射部件和探测器沿与反应杯轴线平行方向依次设置。其中，第二反射部件和探测器可沿与反应杯轴线平行方向，由下至上依次设置，也可由上至下依次设置。
在另一实施例中，第二反射部件32和光线接收机构7沿与反应杯6轴线垂直方向依次设置。此时，第二反射部件和探测器沿与反应杯轴线平行方向依次设置。第二反射部件和探测器可沿与反应杯轴线垂直方向，由内向外依次设置，也可由外向内依次设置。
在另一实施例中，照射机构5还包括准直器41，准直器对光束起到准直的作用。其中，准直器可以使单片透镜，也可以是一组镜片等。但在有些实施例中，也可以不设置准直器，这主要由光源、光纤、参数及检测模块要求决定。
    在另一实施例中，光源、准直器41和第一反射部31件沿与反应杯6轴线平行方向依次设置，如可沿该方向由下至上依次设置，也可由上至下依次设置。
在另一实施例中，光源、准直器41和第一反射部件31沿与反应杯6轴线垂直方向依次设置，如可沿该方向由内向外依次设置，也可由外向内依次设置。
在另一实施例中，照射机构还包括发射光纤21，发射光纤设置在光源和第一反射部件31之间，接收光源发出的光并进行传递。发射光纤可以是一根1分多光纤或单根光纤。但在有些实施例中，可以不采用发射光纤，直接采用光源，具体可根据需要选择。
在另一实施例中，光源、发射光纤21、准直器41和第一反射部件31沿与反应杯6轴线平行方向依次设置，如可沿该方向由下至上依次设置，也可由上至下依次设置。
在另一实施例中，光源、发射光纤21、准直器41和第一反射部件31沿与反应杯6轴线垂直方向依次设置，如可沿该方向由内向外依次设置，也可由外向内依次设置。
在另一实施例中，光线接收机构7还包括耦合器42，耦合器对光束起到准直的作用。其中，耦合器可以使单片透镜，也可以是一组镜片等。但在有些实施例中，也可以不设置耦合器，这主要由光源、光纤、参数及检测模块要求等来决定。
在另一实施例中，第二反射部件32、耦合器42和探测器（图中未示出）沿与反应杯6轴线平行方向依次设置，如可沿该方向由下至上依次设置，也可由上至下依次设置。
在另一实施例中，第二反射部件32、耦合器42和探测器沿与反应杯轴线垂直方向依次设置，如可沿该方向由内向外依次设置，也可由外向内依次设置。
在另一实施例中，光线接收机构7还包括接收光纤22，接收第二反射部件反射32的光束并传递给所述探测器。接收光纤可以是一根1分多光纤或单根光纤。但在有些实施例中，可以不采用接收光纤，直接采用探测器（如PD探测器），具体可根据需要选择。
在另一实施例中，第二反射部件32、耦合器42、接收光纤22和探测器沿与反应杯6轴线平行方向依次设置，如可沿该方向由下至上依次设置，也可由上至下依次设置（由下至上的方向，可参考前述实施例）。
在另一实施例中，第二反射部件32、耦合器42、接收光纤22和探测器沿与反应杯6轴线垂直方向依次设置，如可沿该方向由内向外依次设置，也可由外向内依次设置。
上述实施例中，照射机构各部件的设置方式和光纤接收机构各部件的设置方式，两者可根据需要进行任意组合，如照射机构各部件沿与反应杯轴线平行方向由下至上依次设置，而光纤接收机构各部件可沿与反应杯轴线平行方向由上至下依次设置等。
在另一实施例中，光源、发射光纤21、准直器41和第一反射部件31沿与反应杯6轴线平行方向由下至上依次设置。第二反射部件32、耦合器42、接收光纤22和探测器沿与反应杯6轴线平行方向由上至下依次设置。所述第一反射部件31包括第一反射面311，所述第二反射部件32包括第二反射面322。所述光源发出的光束通过发射光纤21传递给所述准直器41处理后，以与所述第一反射面311呈45度夹角方向入射，然后经第一反射面311反射以垂直反应杯6侧壁方向射入，并从反应杯6相对面垂直侧壁穿出，所述穿出的光束以与所述第二反射面322呈45度夹角方向入射，然后反射给所述耦合器42，经耦合器42处理后被接收光纤22接收，并传递给所述探测器。 
其中，所述发射光纤21和接收光纤22根据需要可为任选的，某些情况下可省略。而且，在使第一反射部件31反射的光束垂直入射反应杯6，该光束从反应杯6穿出后入射到第二反射部件32，即使光路水平穿过反应杯时，可适当的调整第一反射部件和照射机构之间的相对位置和角度，也能使反射光束垂直射入反应杯，也能达到上述效果。此外，也可调整第二反射部件和光线接收机构之间的相对位置和角度，使穿出反应杯的光束经第二反射部件反射后能被光线接收机构接收。
在图3所示的实施例中，与上一实施例（图2所示实施例）存在以下不同，其他相同内容此处不再重复。光源（图中未示出）、发射光纤21、准直器41和第一反射部件31沿与反应杯6轴线平行方向由上至下依次设置。第二反射部件32、耦合器42、接收光纤22和探测器（图中未示出）沿与反应杯6轴线平行方向由下至上依次设置。
在图4所示的实施例中，照射机构还可包括第三反射部件33；光源发出的光束，经发射光纤传21递给准直器41进行准直作用，并传递给所述第三反射部件33，经所述第三反射部件33反射给第一反射部件31，由第一反射部件31反射入反应杯6，并穿过反应杯6射向第二反射部件32。光线接收机构还可包括第四反射部件34；所述光束经所述第二反射部件32反射给所述第四反射部件34，并由所述第四反射部件34反射给耦合器42进行准直作用，然后将光束传递给接收光纤22，进而传递给所述探测器。
其中，同前述实施例，发射光纤、接收光纤、准直器及耦合器，都是可根据需要任选的，即可以选择使用或不使用或使用哪一个或几个等等。
如图4所示实施例中，光源、发射光纤21、准直器41和第三反射部件33沿与第一电磁线圈11平行方向从左向右依次设置，可设置在第一电磁线圈11的下方（或上方）。第四反射部件34、耦合器42、接收光纤22和探测器（图中未示出）沿与第二电磁线圈12平行方向从左向右依次设置，可设置在第二电磁线圈的下方（或上方）。第一反射部件31包括第一反射面311，第二反射部件32包括第二反射面321，第三反射部件33包括第三反射面331，第四反射部件34包括第四反射面341。所述光源发出的光束通过发射光纤21传递给所述准直器41处理后，以与所述第三反射面331呈45度夹角方向入射，然后经第三反射面331反射以与所述第一反射面311呈45度夹角方向入射，经第一反射面311反射后的光束以垂直反应杯6侧壁方向射入，并从反应杯6相对面垂直侧壁穿出，所述穿出的光束以与所述第二反射面321呈45度夹角方向入射，然后经第二反射面321反射以与第四反射面341呈45度夹角方向入射，然后反射给所述耦合器42，经耦合器42处理后被接收光纤22接收，并传递给所述探测器（图中未示出）。
其中，光源、发射光纤、准直器和第三反射部件可沿与反应杯轴线垂直方向依次设置，如可沿该方向由内向外依次设置，也可由外向内依次设置。第四反射部件、耦合器、接收光纤和探测器可沿与反应杯轴线垂直方向依次设置，如可沿该方向由外向内依次设置，也可由内向外依次设置。此外，照射机构各部件的具体设置、以及光线接收机构各部件的具体设置，不限于所列举实施例，可根据实际需要进行设置和调整。
在其他实施例中，在使第一反射部件反射的光束垂直入射反应杯，该光束从反应杯穿出后入射到第二反射部件，即使光路水平穿过反应杯时，可适当的调整第一反射部件和照射机构之间的相对位置和角度，也能使反射光束垂直射入反应杯，也能达到上述效果。此外，也可调整第二反射部件和光线接收机构之间的相对位置和角度，使穿出反应杯的光束经第二反射部件反射后能被光线接收机构接收。
一个实施例中，所述第一反射部件和第二反射部件为反射镜，也可以是直角棱镜，反射镜可为平面反射镜、或非平面反射镜（如有曲率的反射镜）等。其中，非平面反射镜，可为如球面反射镜。非平面反射镜可起到准直的作用，因此可无需设置准直器。
在图5所示实施例中，第一球面反射镜包括第一球面反射面351和第一球面反射底面352，第二球面反射镜包括第二球面反射面361和第二球面反射底面362。所述第一球面反射底面352与反应杯6呈45度角设置，发射光纤21将光源发出的光束以与所述第一球面反射底面352呈45度角入射，然后经第一球面反射面351反射以垂直反应杯6侧壁方向射入，并从反应杯6相对面垂直其侧壁穿出，即光束水平穿过反应杯，所述穿出的光束以与所述第二球面反射底面362呈45度夹角方向入射，然后经第二球面反射面361反射给接收光纤22。 其中，同前述实施例，发射光纤和接收光纤，都是可根据需要任选的。
此外，第一球面反射底面与反应杯的所呈角度、第二球面反射底面与反应杯的所呈角度，可根据检测需要进行调节。相应的其他光学部件如光源、发射光纤、接收光纤及探测器也可适应性的进行位置和角度的调整。
上述实施例中，既可通过四块反射镜对光路两次转折，也可通过两块反射镜对光路一次转折。但不限于此，通过对检测光路进行合理的转折，实现在减少样本液量的情况下，同时完成对磁珠项目和光学项目的检测，达到节省试剂的效果，其他方案也在本申请的保护范围内。
在一个实施例中，设置第一电磁线圈和第二电磁线圈，使两者的轴线重合。设置第一反射部件和第二反射部件，使其之间的传播光路在所述轴线之上，或与所述轴线基本重合。为了更好的保证光学法检测时，检测光路穿过反应杯侧壁的位置，避开反应杯底部的圆弧位置，且可减少样本液用量。
在一个实施例中，检测时，反应杯中可选择加入磁珠，不加入磁珠，或取出磁珠。其中，所述磁珠为钢珠。例如：在进行凝血四项磁珠法检测时，将反应杯中加入钢珠进行正常的凝血4项检测；在进行光学法检测时，将钢珠取出，如图6所示，由于取出钢珠，穿过反应杯的检测光路可进一步下降，从而进一步减小总检测液量。
本发明实施例还提供一种样本分析仪，包括壳体、以及上述任一实施例所述的样本检测模块，所述样本检测模块设置在所述壳体内。其中，所述样本分析仪为凝血分析仪，可以同时完成对磁珠项目和光学项目的检测，另一方面，通过光路的转折减少了光学项目的样本用液量，节省试剂。
以上应用了具体个例对本发明进行阐述，只是用于帮助理解本发明，并不用以限制本发明。对于本发明所属技术领域的技术人员，依据本发明的思想，还可以做出若干简单推演、变形或替换。

Claims (20)

  1. 一种样本检测模块，其特征在于：包括照射机构、第一反射部件、第二反射部件、第一电磁线圈、第二电磁线圈和光线接收机构；
    所述第一电磁线圈和第二电磁线圈相对设置在反应杯的两侧；且所述第一电磁线圈和第二电磁线圈与所述反应杯之间均具有间隙；
    在所述第一电磁线圈和所述反应杯之间的间隙设有所述第一反射部件，在所述第二电磁线圈和所述反应杯之间的间隙设有所述第二反射部件；
    所述照射机构至少包括光源；
    所述光线接收机构至少包括探测器；
    所述光源发出的光束由第一反射部件反射入反应杯，并穿过反应杯由第二反射部件反射给所述探测器。
  2. 如权利要求1所述的样本检测模块，其特征在于：所述光源和第一反射部件沿与反应杯轴线平行方向依次设置；或者，所述光源和第一反射部件沿与反应杯轴线垂直方向依次设置。
  3. 如权利要求2所述的样本检测模块，其特征在于：所述探测器和第二反射部件沿与反应杯轴线平行方向依次设置；或者，所述探测器和第二反射部件沿与反应杯轴线垂直方向依次设置。
  4. 如权利要求1所述的样本检测模块，其特征在于：所述照射机构还包括发射光纤，所述发射光纤设置在所述光源和第一反射部件之间，接收所述光源发出的光并进行传递。
  5. 如权利要求1-4任一项所述的样本检测模块，其特征在于：所述照射机构还包括准直器，处理所述光源发出的光束使其按照设定的方向传播给所述第一反射部件。
  6. 如权利要求1-4任一项所述的样本检测模块，其特征在于：所述光线接收机构还包括耦合器，处理第二反射部件反射的光束使其按照设定的方向传播。
  7. 如权利要求1-4任一项所述的样本检测模块，其特征在于：所述光线接收机构还包括接收光纤，接收第二反射部件反射的光束并传递给所述探测器。
  8. 如权利要求5所述的样本检测模块，其特征在于：所述光源、准直器和第一反射部件沿与反应杯轴线平行方向依次设置；或者，所述光源、准直器和第一反射部件沿与反应杯轴线垂直方向依次设置。
  9. 如权利要求6所述的样本检测模块，其特征在于：所述第二反射部件、耦合器和探测器沿与反应杯轴线平行方向依次设置；或者，所述第二反射部件、耦合器和探测器沿与反应杯轴线垂直方向依次设置。
  10. 如权利要求9所述的样本检测模块，其特征在于：所述第一反射部件包括第一反射面，所述第二反射部件包括第二反射面；所述光源发出的光束经过所述准直器处理后，以与所述第一反射面呈45度夹角方向入射，然后经第一反射面反射以垂直反应杯侧壁方向射入，并从反应杯相对面的侧壁垂直穿出，所述穿出的光束以与所述第二反射面呈45度夹角方向入射，然后反射给所述耦合器，经耦合器处理后传递给所述探测器。
  11. 如权利要求1所述的样本检测模块，其特征在于：所述照射机构还包括准直器和第三反射部件；所述准直器，处理所述光源发出的光束使其按照设定的方向传播给所述第三反射部件，经所述第三反射部件反射给第一反射部件，由第一反射部件反射入反应杯，并穿过反应杯射给第二反射部件。
  12. 如权利要求11所述的样本检测模块，其特征在于：所述光线接收机构还包括耦合器和第四反射部件；所述光束经所述第二反射部件反射给所述第四反射部件，并由所述第四反射部件反射给所述耦合器，经所述耦合器处理后传递给所述探测器。
  13. 如权利要求12所述的样本检测模块，其特征在于：所述光源、准直器和第三反射部件沿与所述第一电磁线圈平行方向依次设置。
  14. 如权利要求13所述的样本检测模块，其特征在于：所述第四反射部件、耦合器和探测器沿与所述第二电磁线圈平行方向依次设置。
  15. 如权利要求1所述的样本检测模块，其特征在于：设置所述第一电磁线圈和第二电磁线圈，使两者的轴线重合；设置所述第一反射部件和第二反射部件，使其之间的传播光路在所述轴线之上，或与所述轴线基本重合。
  16. 如权利要求1-4任一项所述的样本检测模块，其特征在于：所述第一反射部件和第二反射部件为平面反射镜或非平面反射镜。
  17. 如权利要求4所述的样本检测模块，其特征在于：所述发射光纤为1分多光纤或单根光纤。
  18. 如权利要求7所述的样本检测模块，其特征在于：所述接收光纤均为1分多光纤或单根光纤。
  19. 如权利要求1所述的样本检测模块，其特征在于：所述反应杯内设有磁珠。
  20. 一种样本分析仪，其特征在于：包括壳体、以及如权利要求1-19任一项所述的样本检测模块，所述样本检测模块设置在所述壳体内。
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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1997882A (zh) * 2004-05-20 2007-07-11 因弗内斯医疗瑞士公司 探测血液凝固的器件与方法
CN101308149A (zh) * 2008-07-16 2008-11-19 上海凯颐医疗仪器有限公司 血液凝固时间测量装置及其测量方法
WO2009123555A1 (en) * 2008-04-01 2009-10-08 Tommy Forsell Blood viscosity analysis
CN202974866U (zh) * 2012-10-26 2013-06-05 北京众驰伟业科技发展有限公司 一种双方法学凝血测试机芯
CN203148811U (zh) * 2013-03-27 2013-08-21 山西亚森实业有限公司 血凝分析仪
US20170370905A1 (en) * 2014-12-15 2017-12-28 Diagnostica Stago Method and device for determining the coagulation time of a blood sample, and reaction vessel
CN108872615A (zh) * 2018-04-26 2018-11-23 迪瑞医疗科技股份有限公司 一种耦合式凝血测试系统及方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3967934A (en) * 1969-06-13 1976-07-06 Baxter Laboratories, Inc. Prothrombin timer
FR2634020B2 (fr) * 1987-12-30 1991-02-22 Serbio Cuvette pour analyseur biologique
JP2002357594A (ja) * 2001-03-28 2002-12-13 Olympus Optical Co Ltd 磁気粒子識別装置及び磁気粒子識別方法
US9068977B2 (en) * 2007-03-09 2015-06-30 The Regents Of The University Of Michigan Non-linear rotation rates of remotely driven particles and uses thereof
US20100188076A1 (en) * 2007-07-09 2010-07-29 Koninklijke Philips Electronics N.V. Microelectronic sensor device with magnetic field generator and carrier
WO2009019619A1 (en) * 2007-08-09 2009-02-12 Koninklijke Philips Electronics N. V. Microelectronic sensor device for optical examinations in a sample medium
US8822227B2 (en) * 2008-02-06 2014-09-02 Koninklijke Philips N.V. Magnetic bead actuation using feedback for FTIR biosensor
CN201903548U (zh) * 2010-12-16 2011-07-20 北京普利生仪器有限公司 半自动凝血分析仪
US8697449B2 (en) * 2011-04-01 2014-04-15 Spectral Sciences, Inc. Optical blood coagulation monitor and method
EP2581744A1 (en) * 2011-10-14 2013-04-17 Koninklijke Philips Electronics N.V. Method for detection of coagulation activity and biomarkers
CN202421019U (zh) * 2012-02-01 2012-09-05 武汉艾尔夫分析仪器有限公司 一种半自动血凝仪的测试装置
CN103926219B (zh) * 2014-05-06 2016-03-23 苏州大学 一种用于人工器官表面凝血在线检测的装置及检测方法
CN106168573A (zh) * 2015-09-06 2016-11-30 深圳雷杜生命科学股份有限公司 一种光学检测系统及包括该系统的凝血仪
CN205210096U (zh) * 2015-12-10 2016-05-04 吕铝淼 一种血凝分析仪
CN106226178B (zh) * 2016-07-15 2018-08-17 重庆鼎润医疗器械有限责任公司 一种采用毛细管内血样振动检测凝血状态的装置
EP3671218A4 (en) * 2017-08-16 2021-07-21 Beijing Precil Instrument Co., Ltd. BLOOD ANALYZER AND CONTROL PROCEDURE FOR IT
CN107765021B (zh) * 2017-11-24 2024-07-12 北京众驰伟业科技发展有限公司 一种测试杯集成式测试位
CN108918413A (zh) * 2018-07-11 2018-11-30 迪瑞医疗科技股份有限公司 一种多波长凝血测试装置
CN109856410A (zh) * 2019-02-15 2019-06-07 王振华 一种血凝测试装置

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1997882A (zh) * 2004-05-20 2007-07-11 因弗内斯医疗瑞士公司 探测血液凝固的器件与方法
WO2009123555A1 (en) * 2008-04-01 2009-10-08 Tommy Forsell Blood viscosity analysis
CN101308149A (zh) * 2008-07-16 2008-11-19 上海凯颐医疗仪器有限公司 血液凝固时间测量装置及其测量方法
CN202974866U (zh) * 2012-10-26 2013-06-05 北京众驰伟业科技发展有限公司 一种双方法学凝血测试机芯
CN203148811U (zh) * 2013-03-27 2013-08-21 山西亚森实业有限公司 血凝分析仪
US20170370905A1 (en) * 2014-12-15 2017-12-28 Diagnostica Stago Method and device for determining the coagulation time of a blood sample, and reaction vessel
CN108872615A (zh) * 2018-04-26 2018-11-23 迪瑞医疗科技股份有限公司 一种耦合式凝血测试系统及方法

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