WO2021016680A1 - Composition d'écran solaire anhydre comprenant un aérogel de silice - Google Patents

Composition d'écran solaire anhydre comprenant un aérogel de silice Download PDF

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Publication number
WO2021016680A1
WO2021016680A1 PCT/BR2019/050297 BR2019050297W WO2021016680A1 WO 2021016680 A1 WO2021016680 A1 WO 2021016680A1 BR 2019050297 W BR2019050297 W BR 2019050297W WO 2021016680 A1 WO2021016680 A1 WO 2021016680A1
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compounds
weight
composition
sunscreen composition
anhydrous
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PCT/BR2019/050297
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English (en)
Inventor
Beatriz Tavares FERREIRA
Lais Moreira LIMA
Angeles FONOLLA-MORENO
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L'oreal
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Priority to PCT/BR2019/050297 priority Critical patent/WO2021016680A1/fr
Priority to BR112021023914-6A priority patent/BR112021023914B1/pt
Publication of WO2021016680A1 publication Critical patent/WO2021016680A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/31—Anhydrous

Definitions

  • the present disclosure is directed to anhydrous sunscreen compositions. More specifically, the present disclosure is directed to anhydrous sunscreen compositions having one or more of appealing aesthetics, phase stability, and high SPF, comprising high concentration of silica aerogel.
  • UVA/UVB sunscreen compositions used to accomplish photoprotection, namely, inorganic UV- filters and organic UV-filters.
  • the degree of UV protection afforded by a sunscreen composition is directly related to the amount and type of UV-filters contained therein. The higher the amount of UV-filters, the greater the degree of UV protection (UVA/UVB). Particularly, sunscreen compositions must provide good protection against the sun, a measure of which is the Sun Protection Factor (SPF) value, yet have satisfactory sensory perception, such as a smooth but not greasy feel upon application.
  • SPF Sun Protection Factor
  • sunscreen products may be in the form of lotions, milks, creams, gels, gel creams, foams, sprays and sticks.
  • Such products can be anhydrous or in the form of emulsions, generally containing sunscreen actives that are solubilized, emulsified, or dispersed in a vehicle, which is topically applied onto the skin.
  • the sunscreen actives typically through the aid of polymers and other ingredients included in the vehicle, form a thin, protective, and often water-resistant layer on the skin.
  • Hydrophobic silica is commonly known in the cosmetic industry for providing anti-oiliness and anti-acne effects, including in sunscreen compositions.
  • the maximum concentration of silica in a composition is limited, due to its high hydrophobic properties, thereby rendering the composition instable when high concentrations of silica are applied.
  • sunscreen compositions are usually limited to have about 0.5% by weight of silica, relative to the total weight of the composition.
  • the inventors have identified a need for sunscreen compositions having higher concentrations of silica aerogel, in order to enhance the aesthetic appeal.
  • the challenge of incorporating high concentrations of silica aerogel in the sunscreen composition is not only limited due to the hydrophobic nature of the silica, but there is also the challenge of formulating stable compositions while preserving satisfactory properties of the product.
  • anhydrous sunscreen composition that enables the high concentration of silica aerogel.
  • the anhydrous sunscreen composition of the present invention having high concentration of silica aerogel surprisingly showed an appealing viscous, honey-like texture, good stability as well as SPF.
  • the present disclosure relates to an anhydrous sunscreen composition including at least about 5% by weight of silica aerogel, relative to the total weight of the composition. It further includes a spherical amorphous silica, an organic UV-filter, and non UV-absorbing fatty compounds including an ester of sebacic acid.
  • anhydrous sunscreen compositions of the present invention can comprise, consist of, or consist essentially of the essential elements and limitations of the present invention described herein, as well as any of the additional or optional ingredients, components, or limitations described herein.
  • the expression“at least one” means one or more and thus includes individual components as well as mixtures/combinations.
  • all ranges provided are meant to include every specific range within, and combination of sub ranges between, the given ranges.
  • “from about 1 %, 2% or 3% to about 5%, 10% or 15%” includes about 1 % to about 5%, about 1% to about 10%, about 1 % to about 15%, about 2% to about 5%, about 2% to about 10%, about 2% to about 15%, about 3% to about 5%, about 3% to about 10%, and/or about 3% to about 15%.
  • all numbers expressing quantities of ingredients and/or reaction conditions are to be understood as being modified in all instances by the term“about,” meaning within 15% such as within 10%, such as within 5% of the indicated number. All concentrations listed are by weight percent relative to the entire composition unless specifically described otherwise.
  • “Anhydrous” as used herein means that the sunscreen composition of the present invention, and the essential or optional components thereof, are essentially free of water and, in certain embodiments are substantially free of water.
  • the “silica aerogel” according to the present invention is a porous material obtained by replacing (by drying) the liquid component of a silica gel with air.
  • Silica aerogels are generally synthesized via a sol-gel process in a liquid medium and then dried, usually by extraction with a supercritical fluid, such as, but not limited to, supercritical carbon dioxide (CO2). This type of drying makes it possible to avoid shrinkage of the pores and of the material.
  • a supercritical fluid such as, but not limited to, supercritical carbon dioxide (CO2).
  • CO2 supercritical carbon dioxide
  • the amount of silica aerogel in the anhydrous sunscreen composition of the present invention is at least about 5% by weight, relative to the total weight of the composition, preferably from about 5% by weight to about 10% by weight, more preferably from about 5% by weight to about 8% by weight such as from about 5% to about 7% by weight, relative to the total weight of the composition.
  • the silica aerogel (e.g., hydrophobic silica aerogel particles) used in the present invention have a specific surface area per unit of mass (SM) ranging from about 500 to about 1500 m 2 /g, or alternatively from about 600 to about 1200 m 2 /g, or alternatively from about 600 to about 800 m 2 /g, and a size expressed as the mean volume diameter (D[0.5]), ranging from about 1 to about 30 pm, or alternatively from about 5 to about 25 pm, or alternatively from about 5 to about 20 pm, or alternatively from about 5 to about 15 miti.
  • the specific surface area per unit of mass may be determined via the BET (Brunauer-Emmett-Teller) nitrogen absorption method described in the Journal of the American Chemical Society, vol. 60, page 309, February 1938, corresponding to the international standard ISO 5794/1.
  • the BET specific surface area corresponds to the total specific surface area of the particles under consideration.
  • the size of the particles may be measured by static light scattering using a commercial granulometer such as the MasterSizer 2000 machine from Malvern.
  • the data are processed on the basis of the Mie scattering theory.
  • This theory which is exact for isotropic particles, makes it possible to determine, in the case of non-spherical particles, an "effective" particle diameter. This theory is especially described in the publication by Van de Hulst, H.C., "Light Scattering by Small Particles," Chapters 9 and 10, Wiley, New York, 1957.
  • the particles used in the present invention may advantageously have a tamped (or tapped) density ranging from about 0.04 g/cm 3 to about 0.10 g/cm 3 ’ or alternatively from about 0.05 g/cm 3 to about 0.08 g/cm 3 .
  • this density may be assessed according to the following protocol: 40 g of powder are poured into a measuring cylinder; the measuring cylinder is then placed on a Stav 2003 machine from Stampf Volumeter; the measuring cylinder is then subjected to a series of 2500 packing motions (this operation is repeated until the difference in volume between two consecutive tests is less than 2%); the final volume Vf of packed powder is then measured directly on the measuring cylinder.
  • the tamped density is determined by the ratio m/Vf, in this instance 40/Vf (Vf being expressed in cm 3 and m in g).
  • the hydrophobic silica aerogel particles used in the present invention have a specific surface area per unit of volume Sv ranging from about 5 to about 60 m 2 /cm 3 , or alternatively from about 10 to about 50 m 2 /cm 3 , or alternatively from about 15 to about 40 m 2 /cm 3 .
  • the silica aerogel particles have an oil-absorbing capacity, measured at the wet point, ranging from about 5 to about 18 ml/g, or alternatively from about 6 to about 15 ml/g, or alternatively from about 8 to about 12 ml/g.
  • the oil-absorbing capacity measured at the wet point corresponds to the amount of water that needs to be added to 100 g of particle in order to obtain a homogeneous paste. Wp is measured according to the wet point method or the method for determining the oil uptake of a powder described in standard NF T 30-022.
  • Wp corresponds to the amount of oil adsorbed onto the available surface of the powder and/or absorbed by the powder by measuring the wet point, described below:
  • An amount 2 g of powder is placed on a glass plate, and the oil (isononyl isonanoate) is then added dropwise.
  • mixing is performed using a spatula, and addition of oil is continued until a conglomerate of oil and powder has formed.
  • the oil is added one drop at a time and the mixture is then triturated with the spatula.
  • the addition of oil is stopped when a firm, smooth paste is obtained. This paste must be able to be spread on the glass plate without cracking or forming lumps.
  • the volume Vs (expressed in ml) of oil used is then noted.
  • the oil uptake corresponds to the ratio Vs/m.
  • the aerogels used, according to the present invention are hydrophobic silica aerogels, preferably of silylated silica (INCI name: silica silylate).
  • silylated silica preferably of silylated silica (INCI name: silica silylate).
  • silylating agents for example, halogenated silanes, such as alkylchlorosilanes, siloxanes, in particular dimethylsiloxanes, such as hexamethyldisiloxane, or silazanes, so as to functionalize the OH groups with silyl groups Si-Rn, for example, trimethylsilyl groups.
  • hydrophobic silica aerogel particles that have been surface-modified by silylation, is found in U.S. Patent No. 7,470,725, incorporated herein by reference.
  • hydrophobic silica aerogel particles surface-modified with trimethylsilyl groups are desirable.
  • Suitable examples of hydrophobic silica aerogels may include, but are not limited to, the aerogels sold under the tradenames of VM-2260 (INCI name: Silica silylate) and VM-2270 (INCI name: Silica silylate), both available from Dow Corning Corporation (Midland, Michigan).
  • the particles of VM-2260 have a mean size of about 1000 microns and a specific surface area per unit of mass ranging from 600 to 800 m 2 /g.
  • the particles of VM-2270 have a mean size ranging from 5 to 15 microns and a specific surface area per unit of mass ranging from 600 to 800 m 2 /g.
  • hydrophobic silica aerogel may include, but is not limited to, the aerogels commercially available from Cabot Corporation (Billerica, Massachusetts) under the tradename of Aerogel TLD 201 , Aerogel OGD 201 and Aerogel TLD 203, Enova Aerogel MT 1 100 and Enova Aerogel MT 1200.
  • the silica aerogel is preferably hydrophobic silica aerogel, more preferably silica silylate.
  • the silica aerogel is present in compositions of the invention in a concentration by weight of at least about 5%, such as from about 5% to about 10%, such as from about 5% to about 8%, such as from about 5% to about 7% or about 6% to about 8%, such as from about 6% to about 7%
  • composition comprises a UV- filter system comprising at least one organic (ultraviolet) UV-filter.
  • UV-filter it is meant a material that attenuates ultraviolet radiation appreciably. If two or more organic UV-filters are used, they may be the same or different.
  • the organic UV-filter used for the present invention may be active in the UV- A and/or UV-B region.
  • the organic UV-filter may be hydrophilic and/or lipophilic.
  • the organic UV-filter may be solid or liquid.
  • solid and liquid mean solid and liquid, respectively, at 25°C under 1 atm.
  • the organic UV-filter can be selected from the group consisting of anthranilic compounds; dibenzoylmethane compounds; cinnamic compounds; salicylic compounds; camphor compounds; benzophenone compounds; b,b- diphenylacrylate compounds; triazine compounds; benzotriazole compounds; benzalmalonate compounds; benzimidazole compounds; imidazoline compounds; bis-benzoazolyl compounds; p-aminobenzoic acid (PABA) compounds; methylenebis(hydroxyphenylbenzotriazole) compounds; benzoxazole compounds; screening polymers and screening silicones; dimers derived from a-alkylstyrene; 4,4- diarylbutadienes compounds; guaiazulene and derivatives thereof; rutin and derivatives thereof; flavonoids; bioflavonoids; oryzanol and derivatives thereof; quinic acid and derivatives thereof; phenols; retinol; cysteine; aromatic amino acids;
  • Anthranilic compounds menthyl anthranilates, such as marketed under the trademark "Neo Heliopan MA” by Haarmann and Reimer.
  • the dibenzoylmethane compounds Butyl methoxydibenzoylmethane, such as marketed in particular under the trademark "Parsol 1789” by Hoffmann-La Roche; and isopropyl dibenzoylmethane.
  • Cinnamic compounds Ethylhexyl methoxycinnamate, such as marketed in particular under the trademark "Parsol MCX” by Hoffmann-La Roche; isopropyl methoxycinnamate; isopropoxy methoxycinnamate; isoamyl methoxycinnamate, such as marketed under the trademark "Neo Heliopan E 1000" by Haarmann and Reimer; cinoxate (2- ethoxyethyl-4-methoxy cinnamate); DEA methoxycinnamate; diisopropyl methylcinnamate; and glyceryl ethylhexanoate dimethoxycinnamate.
  • Salicylic compounds Homosalate (homomentyl salicylate), such as marketed under the trademark "Eusolex HMS” by Rona/EM Industries; ethylhexyl salicylate, such as marketed under the trademark “Neo Heliopan OS” by Haarmann and Reimer; glycol salicylate; butyloctyl salicylate; phenyl salicylate; dipropyleneglycol salicylate, such as marketed under the trademark “Dipsal” by Scher; and TEA salicylate, such as marketed under the trademark "Neo Heliopan TS” by Haarmann and Reimer.
  • Homosalate homomentyl salicylate
  • ethylhexyl salicylate such as marketed under the trademark "Neo Heliopan OS” by Haarmann and Reimer
  • glycol salicylate butyloctyl salicylate
  • phenyl salicylate dipropyleneglycol salicylate
  • TEA salicylate
  • Camphor compounds in particular, benzylidenecamphor derivatives: 3-benzylidene camphor, such as manufactured under the trademark “Mexoryl SD” by Chimex; 4- methylbenzylidene camphor, such as marketed under the trademark “Eusolex 6300” by Merck; benzylidene camphor sulfonic acid, such as manufactured under the trademark “Mexoryl SL” by Chimex; camphor benzalkonium methosulfate, such as manufactured under the trademark “Mexoryl SO” by Chimex; terephthalylidene dicamphor sulfonic acid, such as manufactured under the trademark “Mexoryl SX” by Chimex; and polyacrylamidomethyl benzylidene camphor, such as manufactured under the trademark "Mexoryl SW” by Chimex.
  • 3-benzylidene camphor such as manufactured under the trademark "Mexoryl SD” by Chimex
  • 4- methylbenzylidene camphor such as
  • Benzophenone compounds Benzophenone-1 (2,4-dihydroxybenzophenone), such as marketed under the trademark "Uvinul 400" by BASF; benzophenone-2 (Tetrahydroxybenzophenone), such as marketed under the trademark "Uvinul D50” by BASF; Benzophenone-3 (2- hydroxy-4-methoxybenzophenone) or oxybenzone, such as marketed under the trademark "Uvinul M40" by BASF; benzophenone-4 (hydroxymethoxy benzophonene sulfonic acid), such as marketed under the trademark "Uvinul MS40" by BASF; benzophenone-5 (Sodium hydroxymethoxy benzophenone Sulfonate); benzophenone-6 (dihydroxy dimethoxy benzophenone); such as marketed under the trademark "Helisorb 11 " by Norquay; benzophenone-8, such as marketed under the trademark "Spectra-Sorb UV-24" by American Cyanamid; benzophenone-9 (Dis
  • Triazine compounds Diethylhexyl butamido triazone, such as marketed under the trademark “Uvasorb FIEB” by Sigma 3V; 2,4,6-tris(dineopentyl 4'-aminobenzalmalonate)-s-triazine, bis- ethylhexyloxyphenol methoxyphenyl triazine, such as marketed under the trademark «TINOSORB S » by CIBA GEIGY, and ethylhexyl triazone, such as marketed under the trademark «UVTNUL T150 » by BASF.
  • Benzotriazole compounds in particular, phenylbenzotriazole derivatives: 2-(2FI-benzotriazole-2-yl)-6-dodecyl-4-methylpheno, branched and linear; and those described in USP 5240975.
  • Benzalmalonate compounds Dineopentyl 4'-methoxybenzalmalonate, and polyorganosiloxane comprising benzalmalonate functional groups, such as polysilicone-15, such as marketed under the trademark "Parsol SLX" by Floffmann-LaRoche.
  • Benzimidazole compounds in particular, phenylbenzimidazole derivatives: Phenylbenzimidazole sulfonic acid, such as marketed in particular under the trademark “Eusolex 232" by Merck, and disodium phenyl dibenzimidazole tetrasulfonate, such as marketed under the trademark "Neo Fleliopan AP” by Flaarmann and Reimer.
  • Imidazoline compounds Ethylhexyl dimethoxybenzylidene dioxoimidazoline propionate.
  • Bis- benzoazolyl compounds The derivatives as described in EP-669,323 and U.S. Pat. No. 2,463,264.
  • Para-aminobenzoic acid compounds PABA (p-aminobenzoic acid), ethyl PABA, Ethyl dihydroxypropyl PABA, pentyl dimethyl PABA, ethylhexyl dimethyl PABA, such as marketed in particular under the trademark "Escalol 507" by ISP, glyceryl PABA, and PEG-25 PABA, such as marketed under the trademark "Uvinul P25" by BASF.
  • PABA p-aminobenzoic acid
  • ethyl PABA Ethyl dihydroxypropyl PABA
  • pentyl dimethyl PABA ethylhexyl dimethyl PABA
  • PEG-25 PABA such as marketed under the trademark "Uvinul P25” by BASF.
  • Methylene bis-(hydroxyphenylbenzotriazol) compounds such as 2,2'- methylenebis[6-(2FI-benzotriazol-2-yl)-4-methyl-phenol], such as marketed in the solid form under the trademark "Mixxim BB/200" by Fairmount Chemical, 2,2'- methylenebis[6-(2FI-benzotriazol-2-yl)-4-(l,l,3,3-tetramethylbutyl)phenol], such as marketed in the micronized form in aqueous dispersion under the trademark "Tinosorb M" by BASF, or under the trademark "Mixxim BB/100” by Fairmount Chemical, and the derivatives as described in U.S. Pat. Nos.
  • Drometrizole trisiloxane such as marketed under the trademark "Silatrizole” by Rhodia Chimie or- "Mexoryl XL” by L’Oreal.
  • Benzoxazole compounds 2,4-bis[5- l(dimethylpropyl)benzoxazol-2-yl-(4-phenyl)imino]- 6-(2-ethylhexyl)imino-l,3,5-triazine, such as marketed under the trademark of Uvasorb K2A by Sigma 3V.
  • the organic UV-filter(s) be selected from the group consisting of: butyl methoxydibenzoylmethane, ethylhexyl methoxycinnamate, homosalate, ethylhexyl salicylate, octocrylene, phenylbenzimidazole sulfonic acid, benzophenone-3, benzophenone-4, benzophenone-5, n-hexyl 2-(4-diethylamino-2-hydroxybenzoyl)benzoate, l,r-(l,4- piperazinediyl)bis[l-[2-[4-(diethylamino)-2-hydroxybenzoyl]phenyl]-methanone 4- methylbenzylidene camphor, terephthalylidene dicamphor sulfonic acid, disodium phenyl dibenzimidazole tetrasulfonate, ethyl
  • the sunscreen compositions of the present invention include an inorganic UV-filter.
  • the inorganic UV-filter used for the present invention may be active in the UV-A and/or UV-B region; and may be hydrophilic and/or lipophilic.
  • the inorganic UV-filter is generally insoluble in solvents, such as water, and ethanol commonly used in cosmetics.
  • the inorganic UV-filter can be selected from the group consisting of silicon carbide, metal oxides which may or may not be coated, and mixtures thereof. And in some embodiments, the inorganic UV-filters are selected from pigments (mean size of the primary particles: generally from about 5 nm to about 50 nm, and in some embodiments from about 10 nm to about 50 nm) formed of metal oxides, such as, for example, pigments formed of titanium oxide (amorphous or crystalline in the rutile and/or anatase form), iron oxide, zinc oxide, zirconium oxide, or cerium oxide, which are all UV photoprotective agents that are well known per se.
  • pigments mean size of the primary particles: generally from about 5 nm to about 50 nm, and in some embodiments from about 10 nm to about 50 nm
  • metal oxides such as, for example, pigments formed of titanium oxide (amorphous or crystalline in the rutile and/or anatase form), iron oxide, zinc oxide
  • the inorganic UV-filters are selected from titanium oxide, zinc oxide, and, in some embodiments, titanium oxide.
  • the inorganic UV-filter may or may not be coated. With one or more coatings such as alumina, silica, aluminum hydroxide, silicones, silanes, fatty acids or salts thereof (such as sodium, potassium, zinc, iron, or aluminum salts), fatty alcohols, lecithin, amino acids, polysaccharides, proteins, alkanolamines, waxes, such as beeswax, (meth)acrylic polymers, organic UV-filters, and (per)fluoro compounds.
  • alumina silica, aluminum hydroxide, silicones, silanes, fatty acids or salts thereof (such as sodium, potassium, zinc, iron, or aluminum salts), fatty alcohols, lecithin, amino acids, polysaccharides, proteins, alkanolamines, waxes, such as beeswax, (meth)acrylic polymers, organic
  • the composition may include the UV-filter system in an amount of from about 0.1 % by weight to about 50% by weight, and in some embodiments from about 1 % by weight to about 40% by weight, and in some embodiments from about 10% by weight to about 40% by weight, such as about 15% to about 30% in relation to the total weight of the composition.
  • the concentration of organic UV-filters is present in one or more of the concentration ranges noted in this paragraph.
  • compositions of the present invention may include an inorganic color pigment (i.e., inorganic pigments having at least some inorganic substrate, coating or constituent).
  • inorganic color pigment i.e., inorganic pigments having at least some inorganic substrate, coating or constituent.
  • the compositions of the present invention are essentially free, substantially free or devoid of inorganic color pigments.
  • Suitable inorganic color pigments include any of various inorganic pigments that impart tinting or color in a cosmetic composition, such as iron oxides, ultramarine blue pigments, manganese violet, ferric ferrocyanide and chromium green pigments, pearlescent pigments, effect pigments, and the like.
  • the color pigments may be coated or uncoated, however, in certain notable embodiments uncoated color pigments are used to make the compositions.
  • the inorganic color pigments include or consist of iron oxide.
  • any of various cosmetic grades of color pigments are suitable for use in compositions of the present invention.
  • the color pigments have an average particle size in a range from about 1 micron to about 100 microns, such as from about 1 micron to about 10 microns.
  • the concentration by weight of the inorganic color pigments in the composition may range from about 0.01%, 0.05%, or 0.25% to about 1 %, 2%, 5%, or 10% by weight, including all ranges and subranges therebetween.
  • the uncoated iron oxide pigments are, for example, marketed by Arnaud under the trademarks "Nanogard WCD 2002 (FE 45B)", “Nanogard Iron FE 45 BL AQ”, “Nanogard FE 45R AQ”, and “Nanogard WCD 2006 (FE 45R)", or by Mitsubishi under the trademark "TY-220”.
  • the coated iron oxide pigments are, for example, marketed by Arnaud under the trademarks "Nanogard WCD 2008 (FE 45B FN)", “Nanogard WCD 2009 (FE 45B 556)", “Nanogard FE 45 BL 345", and “Nanogard FE 45 BL”, or by BASF under the trademark "Oxyde de fer transparent”.
  • the sunscreen compositions may include inorganic fillers.
  • compositions of the present invention are substantially free or essentially free of inorganic fillers, such as those having a median particle size from about 0.2 microns to about 1 micron.
  • compositions of the present invention are substantially free or essentially free of titanium dioxide particles having a median particle size from about 0.2 microns to about 1 micron (e.g, Sachtleben Chemie of Duisburg, Germany, under the name "Hombitan FF)."
  • compositions according to the invention include a spherical amorphous silica.
  • the inventors have found that by including the spherical amorphous silica.
  • an anhydrous sunscreen composition having high concentrations of silica aerogel one can form a pleasant honey-like texture.
  • the mean size of these particles of spherical amorphous silica is less than 15.0 pm and more particularly ranges from 3 to 10 pm.
  • the particles of spherical amorphous silica useful according to the invention are colorless or white solid particles of any form, which are in a form that is insoluble and dispersed in the medium of the composition.
  • the spherical amorphous silica may be coated with a hydrophobic treatment agent, although in certain embodiments it is free from such coatings.
  • Suitable examples include porous silica microspheres sold under the name SilicaBeads SB-700 by the company Myoshi (mean size 4.6 pm and oil absorption capacity Wp: 133 ml/100 g); Sunsphere® H51 (mean size 5.1 pm and oil absorption capacity Wp: 133 ml/100 g), Sunsphere® H33 (mean size 2.9 pm and oil absorption capacity Wp: 370 ml/100 g) by the company Asahi Glass;
  • the concentration by weight of the amorphous spherical silica in the composition may range from about 1 %, 1.5%, or 2.0% to about 3.5%, 5%, 6%, 7%, or 10% by weight, including all combinations of such ranges. In certain embodiments, the concentration by weight is less than the concentration of silica aerogel.
  • composition of the present invention may also include additional fatty compounds selected from oils, waxes, fatty acids, fatty alcohols, and mixtures thereof.
  • additional fatty compounds selected from oils, waxes, fatty acids, fatty alcohols, and mixtures thereof.
  • the non UV-absorbing fatty compounds do not appreciably absorb or scatter ultraviolet radiation. Accordingly, as used herein, the term“additional fatty compounds” does not include UV-filters described above described above.
  • Suitable non UV-absorbing fatty compounds include those suitable for providing emolliency to the skin.
  • Examples of such compounds compounds generally insoluble in water and includes a hydrophobic moiety, such as one meeting one or more of the following three criteria: (a) has a carbon chain of at least six carbons in which none of the six carbons is a carbonyl carbon or has a hydrophilic moiety (defined below) bonded directly to it; (b) has two or more alkyl siloxy groups; or (c) has two or more oxypropylene groups in sequence.
  • the hydrophobic moiety may include linear, cyclic, aromatic, saturated or unsaturated groups.
  • the hydrophobic compound is in certain embodiments not amphiphilic and, as such, in this embodiment does not include hydrophilic moieties, such as anionic, cationic, zwitterionic, or nonionic groups, that are polar, including sulfate, sulfonate, carboxylate, phosphate, phosphonate, ammonium, including mono-, di-, and trialkylammonium species, pyridinium, imidazolinium, amidinium, poly(ethyleneiminium), ammonioalkylsulfonate, ammonioalkylcarboxylate, amphoacetate, and poly(ethyleneoxy)sulfonyl moieties.
  • the oil does not include hydroxyl moieties.
  • oils include vegetable oils (glyceryl esters of fatty acids, monoglycerides, diglycerides, triglycerides) and fatty esters.
  • esters such as isopropyl palmitate, isopropyl myristate, isononyl isonanoate C12-C15 alkyl benzoates, caprylic/capric triglycerides, ethylhexyl hydroxystearate, silicone oils (such as dimethicone and cyclopentasiloxane), pentaerythritol tetraoctanoate and mineral oil.
  • oils include liquid organic ultraviolet filter commonly used for example as UV-absorbing sunscreens such as octocrylene, octyl salicylate, octyl methoxyxcinnamate, among others.
  • Suitable oils include volatile and/or non-volatile oils. Such oils can be any acceptable oil including but not limited to silicone oils and/or hydrocarbon oils.
  • compositions of the present invention may include one or more volatile silicone oils.
  • volatile silicone oils include linear or cyclic silicone oils having a viscosity at room temperature less than or equal to 6cSt and having from 2 to 7 silicon atoms, these silicones being optionally substituted with alkyl or alkoxy groups of 1 to 10 carbon atoms.
  • Other volatile oils which may be used include KF 96A of 6 cSt viscosity, a commercial product from Shin Etsu having a flash point of 94°C.
  • the non UV-absorbing compound has a melting point of less than about 30°C.
  • the compositions are substantially free of waxes, e,g, non UV-absorbing fatty compounds that are solid at room temperature (about 25° C.) and atmospheric pressure (760 mm Hg, i.e., 105 Pa), which undergo a reversible solid/liquid change of state and which have a melting point of greater than 30°C., and in some embodiments, greater than about 55° C. up to about 120° C. or even as high as about 200° C.
  • the anhydrous sunscreen composition according to the present invention includes an ester of sebacic acid.
  • a notable sebacic acid ester is a diester of isopropyl alchohol and sebacic acid i.e., diisopropyl sebacate.
  • the non UV-absorbing fatty compounds include diisopropyl sebacate as well as a second non UV-absorbing fatty compounds selected from diisopropyl adipate, isononyl isonanoate, and combinations thereof.
  • the non UV-absorbing fatty compounds include diisopropyl sebacate, diisopropyl adipate, and isononyl isonanoate,
  • anhydrous systems that include high concentrations of silica aerogel and including diisopropyl sebacate show good stability and sensorial effects, particularly when the compositions further include a second non UV-absorbing fatty compound selected from diisopropyl adipate, isononyl isonanoate, and combinations thereof.
  • the concentration by weight of non UV-absorbing fatty compounds in the anhydrous sunscreen composition according to the invention is generally from about 10%, 15%, 20%, 30%, or 40% by weight to about 60%, 70%, 75%, or 80% by weight, relative to the total weight of composition, preferably from about 20% by weight to about 80% by weight, more preferably from about 20% by weight to about 70% by weight, relative to the total weight of the composition.
  • composition of the invention may further comprise any usual cosmetically acceptable ingredient, which may be chosen especially from perfume/fragrance, preserving agents, antioxidants, solvents, actives, vitamins, fillers, silicones, polymers, and mixtures thereof.
  • Suitable polymers include, but are not limited to, aluminum starch octenylsuccinate, xanthan gum, poly C10-30 alkyl acrylate, acrylates/Cio-30 alkyl acrylate crosspolymer, styrene/acrylates copolymer, and mixtures thereof.
  • Non-limiting example of preserving agent which can be used in accordance with the invention include phenoxyethanol.
  • An example of antioxidant is pentaerythrityl tetra-di-t-butyl hydroxyhydrocinnamate.
  • Suitable solvents include, but are not limited alcohols, glycols and polyols such as glycerin, caprylyl glycol, pentylene glycol, propylene glycol, butylene glycol, and mixtures thereof.
  • Suitable additional actives include, but are not limited to, disodium EDTA, triethanolamine, and mixtures thereof.
  • the additional ingredients may represent from 0.1 % to 20%, such as from 0.1 % to 10% or such as from 0.1 to 8% by weight of the total weight of the composition of the invention.
  • Anhydrous sunscreen compositions were prepared with 20% by weight of organic UV-filters (octocrylene, butyl methoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyltriazzine, drometrizole trisiloxane, ethylhexylsalicylate, and ethylhexyl triazone), and amount of silica silylate ranging from 2% to 7%, and the remainder consisted of non UV-absorbing fatty compounds (diisopropyl sebacate, C12-C15 alkyl benzoate, and dicaprylyl ether) and an amount of silica silylate.
  • organic UV-filters octocrylene, butyl methoxydibenzoylmethane, bis-ethylhexyloxyphenol methoxyphenyltriazzine, drometrizole trisiloxane, ethylhe
  • the samples with 2% and 3% of silica silylate were not viscous.
  • the samples with 4% and 5% silica silylate had no remaining sediment and were viscous. These latter two samples were evaluated for phase stability after being placed for one week at 55°C and also at 4°C and was found to be stable.
  • the sample was evaluated tactilly on the skin and the sample with 4% silica silylate showed a very oily texture to the skin and the sample with 5% silica silylate showed a somewhat oily texture to the skin.
  • the sample with 6% silica silylate had no remaining sediment and was viscous.
  • the sample was evaluated for phase stability after being placed for one week at 55°C and also at 4°C and was found to be stable.
  • the sample was evaluated tactilly on the skin and showed a dry texture to the skin, but did not seem to hide imperfections instantly.
  • the sample with 7% silica silylate had no remaining sediment and was viscous.
  • the samples were evaluated for phase stability after being placed for one week at 55°C and also at 4°C and was found to be stable.
  • the sample was evaluated tactilly on the skin and showed a dry texture to the skin, and did seem to hide imperfections instantly.
  • the sample with 8% silica silylate had no remaining sediment and was very viscous.
  • the samples were evaluated for phase stability after being placed for one week at 55°C and also at 4°C and was found to be stable. The sample was not evaluated tactilly on the skin.
  • EVONIK Tego SP C12-C22 alkyl acrylate replacing the silica silylate. The first two were not viscous and the 4% lost its viscosity and became unstable at room temperature.
  • Anhydrous sunscreen compositions were prepared with 20% by weight of organic UV-filters (octocrylene, butyl methoxydibenzoylmethane, bis- ethylhexyloxyphenol methoxyphenyltriazzine, drometrizole trisiloxane, ethylhexylsalicylate, and ethylhexyl triazone), 7%, silica silylate, 5% of a filler material (each sample with a different filler material), and the remainder consisted of non UV- absorbing fatty compounds (diisopropyl sebacate, C12-C15 alkyl benzoate, and dicaprylyl ether) and an amount of silica silylate. Specifically, six samples were made.
  • organic UV-filters octocrylene, butyl methoxydibenzoylmethane, bis- ethylhexyloxyphenol methoxyphenyltri
  • the first sample was made with an inorganic filler, specifically uncoated titanium dioxide, having a median particle size from about 0.2 microns to about 1 micron and having at least 90% of its particles less than about 1 micron and more than 90% of its particles greater than about 0.33 microns (Hombitan FF from Sachtlaben).
  • the sample had pleasant mousse-like texture and was very white.
  • the second sample was made with an inorganic filler, specifically titanium dioxide coated with stearic acid and aluminum hydroxide , having a particle size of about 15nm.
  • the sample was paste-like and hard to spread and showed residue on the skin.
  • the third sample was made with a spherical amorphous silica (Sunsphere® H51 from Asahi Glass).
  • the sample had a pleasant thick, honey-like texture.
  • the fourth sample was made mica having a particle size from about 5- 10 microns. The sample showed a thick, pinkish texture that was opaque and not aesthetically pleasing.
  • the fifth sample was made with expanded perlite having a particle size of about 25 microns. The sample showed a thick, pinkish texture that was not aesthetically pleasing.
  • the sixth sample was made with titanium dioxide encapsulated in silica and having an average particle size more than 2 microns. The sample appeared yellow, opaque and showed some evidence of instability.
  • Anhydrous sunscreen compositions were prepared with 20% by weight of organic UV-filters (octocrylene, butyl methoxydibenzoylmethane, bis- ethylhexyloxyphenol methoxyphenyltriazzine, drometrizole trisiloxane, ethylhexylsalicylate, and ethylhexyl triazone), 7%, silica silylate,, about 1 % other ingredients (fragrance), and the remainder was non UV-absorbing fatty compounds.
  • organic UV-filters octocrylene, butyl methoxydibenzoylmethane, bis- ethylhexyloxyphenol methoxyphenyltriazzine, drometrizole trisiloxane, ethylhexylsalicylate, and ethylhexyl triazone
  • compositions had 10% isononyl isonanoate and 10% diisopropyl adipate and 45% of C12-C15 alkyl benzoate. The remaining 7% of the compositions were allowed to vary - in the amount of diisopropyl sebacate, isopropyl palmitate, and dicaprylyl ether. Three samples were prepared. The compositions were visually and tactilly evaluated for phase stability and sensorial attributes.
  • the remaining 8% was diisopropyl sebacate.
  • the composition was phase stable and had excellent sensorial attributes.
  • the remaining 7% was isopropyl palmitate.
  • the composition was phase stable but was very oily.
  • the remaining 7% was dicaprylyl ether.
  • the composition had acceptable sensorial attributes, but was not phase stable.

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Abstract

L'invention concerne une composition d'écran solaire anhydre comprenant au moins environ 5% en poids d'un aérogel de silice, par rapport au poids total de la composition. L'invention concerne en outre une silice amorphe sphérique, un filtre UV organique et des composés gras absorbant les UV comprenant un ester d'acide sébacique.
PCT/BR2019/050297 2019-07-26 2019-07-26 Composition d'écran solaire anhydre comprenant un aérogel de silice WO2021016680A1 (fr)

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PCT/BR2019/050297 WO2021016680A1 (fr) 2019-07-26 2019-07-26 Composition d'écran solaire anhydre comprenant un aérogel de silice
BR112021023914-6A BR112021023914B1 (pt) 2019-07-26 Composição de filtro solar anidra

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US20140294975A1 (en) * 2011-11-07 2014-10-02 L'oreal Solid anti-sun composition based on lipophilic organic uv screening agent and aerogel particles of hydrophobic silica
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US5240975A (en) 1988-04-11 1993-08-31 Ciba-Geigy Corporation Liquid substituted 2H-benzotriazole mixtures, stabilized compositions
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WO1993004665A1 (fr) 1991-08-29 1993-03-18 L'oreal Composition cosmetique filtrante contenant un polymere filtre liposoluble a structure hydrocarbonee et une silicone filtre
EP0669323A1 (fr) 1994-02-24 1995-08-30 Haarmann & Reimer Gmbh Utilisation de benzazolen comme absorbeurs d'UV nouveaux benzazoles et procédé pour les préparation
GB2303549A (en) 1995-07-22 1997-02-26 Ciba Geigy Ag Micronising organic UV absorbers with alkyl polyglucosides
US7470725B2 (en) 1996-11-26 2008-12-30 Cabot Corporation Organically modified aerogels, processes for their preparation by surface modification of the aqueous gel, without prior solvent exchange, and subsequent drying, and their use
DE19726184A1 (de) 1997-06-20 1998-12-24 Beiersdorf Ag Kosmetische und dermatologische Lichtschutzformulierungen in Form von Emulsionen, insbesondere O/W-Makroemulsionen, O/W-Mikroemulsionen oder O/W/O-Emulsionen, mit einem Gehalt an lichtschutzwirksamen Benzotriazolderivaten
EP0893119A1 (fr) 1997-07-26 1999-01-27 Ciba SC Holding AG Formulation protectrice contre UV
DE19855649A1 (de) 1998-12-03 2000-06-08 Basf Ag Dimere alpha-Alkyl-Styrolderivate als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen
US20140294975A1 (en) * 2011-11-07 2014-10-02 L'oreal Solid anti-sun composition based on lipophilic organic uv screening agent and aerogel particles of hydrophobic silica
US20140370062A1 (en) * 2011-11-07 2014-12-18 L'oreal Composition with a continuous oil phase containing at least one lipophilic organic uv-screening agent and hydrophobic silica aerogel particles

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