WO2021013412A1 - Corps moulés contenant des agents actifs et procédé de fabrication de ceux-ci - Google Patents

Corps moulés contenant des agents actifs et procédé de fabrication de ceux-ci Download PDF

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Publication number
WO2021013412A1
WO2021013412A1 PCT/EP2020/065010 EP2020065010W WO2021013412A1 WO 2021013412 A1 WO2021013412 A1 WO 2021013412A1 EP 2020065010 W EP2020065010 W EP 2020065010W WO 2021013412 A1 WO2021013412 A1 WO 2021013412A1
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WIPO (PCT)
Prior art keywords
weight
active substance
shaped body
group
mol
Prior art date
Application number
PCT/EP2020/065010
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German (de)
English (en)
Inventor
Mireia SUBINYA
Peter Schmiedel
Ines Baranski
Regina Stehr
Michael Dreja
Filiz Yapici
Boray TORUN
Original Assignee
Henkel Ag & Co. Kgaa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Henkel Ag & Co. Kgaa filed Critical Henkel Ag & Co. Kgaa
Priority to EP20730225.8A priority Critical patent/EP4004173A1/fr
Publication of WO2021013412A1 publication Critical patent/WO2021013412A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0047—Detergents in the form of bars or tablets
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D11/00—Special methods for preparing compositions containing mixtures of detergents
    • C11D11/0082—Special methods for preparing compositions containing mixtures of detergents one or more of the detergent ingredients being in a liquefied state, e.g. slurry, paste or melt, and the process resulting in solid detergent particles such as granules, powders or beads
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/0039—Coated compositions or coated components in the compositions, (micro)capsules
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/06—Powder; Flakes; Free-flowing mixtures; Sheets
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2068—Ethers
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2075—Carboxylic acids-salts thereof
    • C11D3/2086—Hydroxy carboxylic acids-salts thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/2096—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/22—Carbohydrates or derivatives thereof
    • C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/28—Heterocyclic compounds containing nitrogen in the ring
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/32—Amides; Substituted amides
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/26—Organic compounds containing nitrogen
    • C11D3/32—Amides; Substituted amides
    • C11D3/323—Amides; Substituted amides urea or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/34—Organic compounds containing sulfur
    • C11D3/349—Organic compounds containing sulfur additionally containing nitrogen atoms, e.g. nitro, nitroso, amino, imino, nitrilo, nitrile groups containing compounds or their derivatives or thio urea
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3753—Polyvinylalcohol; Ethers or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3757—(Co)polymerised carboxylic acids, -anhydrides, -esters in solid and liquid compositions
    • C11D3/3761—(Co)polymerised carboxylic acids, -anhydrides, -esters in solid and liquid compositions in solid compositions
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3769—(Co)polymerised monomers containing nitrogen, e.g. carbonamides, nitriles or amines
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/50—Perfumes
    • C11D3/502—Protected perfumes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/50—Perfumes
    • C11D3/502—Protected perfumes
    • C11D3/505—Protected perfumes encapsulated or adsorbed on a carrier, e.g. zeolite or clay

Definitions

  • the present application describes active substance-containing moldings and a process for producing active substance-containing moldings.
  • the present application describes in particular fragrance-containing molded articles and processes for their production.
  • fragrance lozenges In order to meet the needs of consumers for long-lasting laundry scenting, special scented lozenges have been offered for some time.
  • Known fragrance lozenges are usually based on carrier polymers such as polyethylene glycol (PEG) with an average molecular weight of approximately 2000 to 12000 g / mol, into which fragrances or fragrance capsules are incorporated.
  • PEG polyethylene glycol
  • the marketing of such systems is associated with high production costs due to the use of high polymer proportions and also pollutes the environment.
  • the commercially available scented lozenges are hard, non-elastic lozenges due to their carrier material, which form or break during transport or when the packaging is shaken vigorously.
  • Scented lozenges based on PEG also often have a non-transparent, inhomogeneous appearance, which is due to the presence of undissolved, unevenly distributed solid particles. These properties contradict the consumer's aesthetic perception.
  • a solvent-based carrier system which, by means of a combination of a low molecular weight gel former with a molar mass ⁇ 2000 g / mol, preferably dibenzylidene sorbitol (DBS), with a polymeric gel former of a molar mass > 10000 g / mol, preferably polyvinyl alcohol, is thickened.
  • a low molecular weight gel former with a molar mass ⁇ 2000 g / mol, preferably dibenzylidene sorbitol (DBS)
  • DBS dibenzylidene sorbitol
  • a first subject of this application is an active substance-containing shaped body with a weight of 0.2 to 20 g, comprising
  • the active substance-containing moldings are preferably dimensionally stable.
  • “Dimensionally stable”, as used herein, refers to the property of the molded body to maintain its three-dimensional shape under the conditions customary for storage and transport, i.e. in the temperature ranges customary for storage and transport and under the action of the forces customary for storage and transport, neither to disintegrate nor to be irreversible Enter into deformations.
  • Particularly preferred moldings are translucent and / or transparent, particularly preferably transparent. If a shaped body according to the invention has a residual light output (transmission) of at least 20% in the spectral range between 380 nm and 780 nm, based on the reference measurement, it is considered transparent in the context of the invention.
  • the transparency of the moldings can be determined using various methods.
  • the nephelometric turbidity unit (nephelometric turbidity value; NTU) is often used as a measured value for transparency. It is a unit used e.g. in water treatment for turbidity measurements e.g. in liquids. It is the unit of turbidity measured with a calibrated nephelometer. High NTU values are measured for opaque compositions, whereas low values are determined for clear compositions.
  • the HACH Turbidimeter 2100Q from the Hach Company, Loveland, Colorado (USA) is used using the calibration tools StabICal Solution HACH (20 NTU), StabICal Solution HACH (100 NTU) and StabICal Solution HACH (800 NTU) , all can also be ordered from Hach Company.
  • the measurement is filled in a 10 ml measuring cuvette with a cap with the composition to be examined and the measurement is carried out at 20 ° C.
  • moldings At an NTU value (at 20 ° C.) of 60 or more, moldings have a perceptible haze that can be seen with the naked eye within the meaning of the invention. It is therefore preferred if the moldings according to the invention have an NTU value (at 20 ° C.) of at most 120, more preferably at most 110, more preferably at most 100, particularly preferably at most 80.
  • the transparency of the moldings according to the invention is determined by a transmission measurement in the visual light spectrum over a wavelength range from 380 nm to 780 nm at 20.degree.
  • a reference sample water, fully demineralized
  • the cuvette is then filled with a sample of the shaped body according to the invention and measured again.
  • the sample is filled in a liquid state at 80 ° C. and solidified in the cuvette to form a shaped body and then measured.
  • the transparent molded body according to the invention has a transmission (20 ° C.) of preferably at least 25%, more preferably at least 30%, more preferably at least 40%, in particular at least 50%, particularly preferably at least 60%.
  • the transparent molding according to the invention has a transmission (at 20 ° C.) of at least 30% (in particular of at least 40%, more preferably of at least 50%, particularly preferably of at least 60%) and an NTU value (at 20 ° C) of at most 120 (more preferably at most 1 10, more preferably at most 100, particularly preferably at most 80).
  • the weight ratio of low molecular weight gel former to polymeric gel former is 10: 1 to 1:20, preferably 8: 1 to 1:15 and in particular 6: 1 to 1:10 .
  • the weight of an individual active substance-containing shaped body is preferably 0.2 to 10 g, more preferably 0.5 to 5 g.
  • the active substance-containing shaped bodies contain as the first essential component a) at least one low molecular weight gel former with a molar mass of up to 2000 g / mol, preferably with a molar mass of 200 g / mol to 2000 g / mol.
  • the use of gel formers with a molar mass of 200 g / mol to 1000 g / mol has proven to be particularly advantageous with regard to producibility, packability and subsequent use.
  • the proportion by weight of the low molecular weight gel former a) in the total weight of the active substance-containing shaped body is preferably from 0.01 to 15% by weight, preferably from 0.1 to 10% by weight and in particular from 1 to 4% by weight.
  • the gel former a) has a solubility in water of less than 0.1 g / L (20 ° C.).
  • the solubility of the organic gelator compound a) is determined at 20 ° C. in double-distilled, demineralized water.
  • gel formers are preferably suitable which have a structure containing at least one hydrocarbon structural unit with 6 to 20 carbon atoms (preferably at least one carbocyclic, aromatic structural unit) and in addition an organic structural unit covalently bonded to the aforementioned hydrocarbon unit, the at least two groups selected from -OH, -NH-, or mixtures thereof.
  • the at least one gelling agent selected from the group consisting of Benzylidenalditol compound, hydroxystearic acid, hydrogenated castor oil, Diarylamidocystin compound, N- (C8-C 24) -Hydrocarbylglyconamid, diketopiperazine compound, 2-methyl-acrylic acid 2-ureido-ethyl ester and mixtures thereof. Because of his The at least one gelling agent dibenzylidene sorbitol (DBS) is particularly more preferred for technical purposes.
  • DBS dibenzylidene sorbitol
  • Particularly preferred shaped bodies are characterized in that said shaped body contains at least one benzylidene alditol compound of the formula (GB-I) as a gel former
  • * - stands for a covalent single bond between an oxygen atom of the alditol backbone and the intended residue
  • n 0 or 1, preferably 1,
  • n 0 or 1, preferably 1,
  • both said benzylidene alditols in the L configuration or in the D configuration or a mixture of both are suitable according to the invention. Because of their natural availability, the benzylidene alditol compounds in the D configuration are preferably used according to the invention.
  • the alditol basic structure of the benzylidene alditol compound according to formula (GB-I) contained in the molded body is derived from D-glucitol, D-mannitol, D-arabinitol, D-ribitol, D-xylitol, L -Glucitol, L-mannitol, L-arabinitol, L-ribitol or L-xylitol.
  • Particularly preferred moldings are those which are characterized in that R 1 , R 2 , R 3 , R 4 , R 5 and R 6 according to the benzylidene alditol compound of the formula (GB-I) independently represent a hydrogen atom, methyl, ethyl, chlorine , Fluorine or methoxy, preferably a hydrogen atom.
  • R 1 , R 2 , R 3 , R 4 , R 5 and R 6 independently represent a hydrogen atom, methyl, ethyl, chlorine , Fluorine or methoxy, preferably a hydrogen atom.
  • n is preferably 1.
  • m preferably represents 1.
  • the molding according to the invention very particularly preferably contains at least one compound of the formula (GB-11) as the benzylidene alditol compound of the formula (GB-I)
  • R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined in formula (I).
  • R 1 , R 2 , R 3 , R 4 , R 5 and R 6 independently of one another represent a hydrogen atom, methyl, ethyl, chlorine, fluorine or methoxy, preferably a hydrogen atom.
  • the benzylidene alditol compound of formula (GB-I) is selected from 1, 3: 2,4-di-O-benzylidene-D-sorbitol; 1, 3: 2,4-di-0- (p-methylbenzylidene) -D-sorbitol; 1, 3: 2,4-di-0- (p-chlorobenzylidene) -D-sorbitol; 1, 3: 2,4-di-0- (2,4-dimethylbenzylidene) -D-sorbitol; 1, 3: 2,4-di-0- (p-ethylbenzylidene) -D-sorbitol; 1, 3: 2,4-di-0- (3,4-dimethylbenzylidene) -D-sorbitol or mixtures thereof.
  • Preferred moldings contain at least one 2,5-diketopiperazine compound of the formula (GB-II) as a gel former
  • R 1 , R 2 , R 3 and R 4 independently of one another represent a hydrogen atom, a hydroxyl group, a (Ci-C6) -alkyl group, a (C2-C6) -alkenyl group, a (C2-C6) -acyl group, a ( C2-C6) - acyloxy group, a (Ci-C6) -alkoxy group, an amino group, a (C2-C6) -acylamino group, a (Ci-C6) -alkylaminocarbonyl group, an aryl group, an aroyl group, an aroyloxy group, an aryloxy group, a Aryl (Ci-C 4 ) alkyloxy group, an aryl (Ci-C3) alkyl group, a heteroaryl group, a Hetroaryl- (Ci-C3) -alkyl distr, a (Ci-C 4 ) -hydroxyalkyl distr, a (Ci
  • R 5 stands for a hydrogen atom, a linear (Ci to C6) -alkyl group, a branched (C3 to C10) -alkyl group, a (C3 to C6) -cycloalkyl group, a (C2-C6) -alkenyl group, a (C2-C6 ) Alkynyl group, a (Ci-C 4 ) -hydroxyalkyl group, a (Ci-C 4 ) -alkoxy- (Ci-C 4 ) -alkyl group, a (Ci-C 4 ) -acyloxy- (Ci- C 4 ) - alkyl group, an aryloxy (Ci-C 4 ) -alkyl group, an 0- (aryl- (Ci-C 4 ) -alkyl) oxy- (Ci-C 4 ) -alkyl group, a (Ci-C 4 ) -Alkylsulfanyl- (
  • R 3 and R 4 according to formula (GB-II) represent a hydrogen atom. It is particularly preferred according to the invention if R 2 , R 3 and R 4 according to formula (GB-II) represent a hydrogen atom. Therefore, particularly preferred moldings according to the invention contain at least one 2,5-diketopiperazine compound according to formula (GB-Ila)
  • R 1 and R 5 are as defined under formula (GB-II) (vide supra).
  • R 1 and R 5 are defined as above under formula (GB-II) (vide supra).
  • the numbers 3 and 6 positioned on the ring atoms in formula (GB-IIb) only mark positions 3 and 6 of the diketopiperazine ring, as they are generally used in the context of the invention for naming all 2,5-diketopiperazines according to the invention.
  • the 2,5-diketopiperazine compounds of the formula (GB-II) have centers of chirality at least on the carbon atoms in positions 3 and 6 of the 2,5-diketopiperazine ring.
  • the numbering of the ring positions 3 and 6 was illustrated by way of example in formula (GB-Ilb).
  • the 2,5-diketopiperazine compound of the formula (GB-II) of the compositions according to the invention is preferably the configuration isomer 3S, 6S, 3R, 6S, 3S based on the stereochemistry of the carbon atoms at the 3- and 6-position of the 2,5-diketopiperazine ring , 6R, 3R, 6R or mixtures thereof, particularly preferably 3S, 6S.
  • Preferred molded articles contain at least one 2,5-diketopiperazine compound of the formula (GB-II) as a gel former, selected from 3-benzyl-6-carboxyethyl-2,5-diketopiperazine, 3-benzyl-6-carboxymethyl-2,5- diketopiperazine, 3-benzyl-6- (p-hydroxybenzyl) -2,5-diketopiperazine, 3-benzyl-6-isopropyl-2,5-diketopiperazine, 3-benzyl-6- (4-aminobutyl) -2, 5-diketopiperazine, 3,6-di (benzyl) -2,5- diketopiperazine, 3,6-di (p-hydroxybenzyl) -2,5-diketopiperazine, 3,6-di (p- (benzyloxy) benzyl) - 2,5-diketopiperazine, 3-benzyl-6- (4-imidazolyl) methyl-2,5
  • the shaped bodies according to the invention may contain at least one diarylamidocystine compound of the formula (GB-III) as gel former a)
  • X + independently represent a hydrogen atom or an equivalent of a cation
  • R 1 , R 2 , R 3 and R 4 independently of one another represent a hydrogen atom, a halogen atom, a C1-C4 alkyl group, a Ci-C 4 alkoxy group, a C 2 -C 4 hydroxyalkyl group, a hydroxyl group, an amino group, an N- (Ci-C 4 -alkyl) amino group, an N, N-di (Ci-C 4 -alkyl) amino group, an N- (C 2 -C 4 - hydroxyalkyl) amino group, an N, N-di ( C 2 -C 4 -hydroxyalkyl) amino group or R 1 with R 2 or R 3 with R 4 forms a 5- or 6-membered fused ring, which in turn each with at least one group from Ci-C 4 -alkyl group, Ci-C 4 -alkoxy group, C 2 -C 4 -hydroxyalkyl group, hydroxyl group, amino group, N- (Ci-C 4
  • Each of the stereocenters contained in the compound of the formula (GB-III) can, independently of one another, stand for the L or D stereoisomer. It is preferred according to the invention if the said cystine compound of the formula (GB-III) is derived from the L-stereoisomer of cysteine.
  • Said shaped bodies can contain at least one compound of the formula (GB-III) in which R 1 , R 2 , R 3 and R 4 independently of one another represent a hydrogen atom, a halogen atom, a Ci-C 4 -alkyl group, a Ci-C 4 -Alkoxy group, a C 2 -C 4 -hydroxyalkyl group, a hydroxyl group, or R 1 with R 2 or R 3 with R 4 forms a 5- or 6-membered fused ring, which in turn each with at least one group from Ci-C 4 -Alkyl group, Ci-C 4 alkoxy group, C 2 -C 4 hydroxyalkyl group, hydroxyl group can be substituted.
  • R 1 , R 2 , R 3 and R 4 independently of one another represent a hydrogen atom, a halogen atom, a Ci-C 4 -alkyl group, a Ci-C 4 -Alkoxy group, a C 2 -C 4 -hydroxy
  • N- (C8-C 24 ) -hydrocarbylglyconamide compounds suitable as gel formers a) preferably have the formula (GB-IV)
  • n 2 to 4, preferably 3 or 4, especially 4;
  • R 1 is selected from hydrogen, C1-C16 alkyl radicals, C1-C3 hydroxy or methoxyalkyl radicals, preferably C1-C3 alkyl, hydroxyalkyl or methoxyalkyl radicals, particularly preferably methyl;
  • R 2 is selected from C8-C24 alkyl, Cs-C 24 -Monoalkenylresten, Cs-C 24 -Dialkenylresten, Cs C 24 -Trialkenylresten, Cs-C 24 -hydroxyalkyl, Cs-C 24 -Hydroxyalkenylresten, C1-C3 Hydroxyalkyl radicals or methoxy-Ci-C3-alkyl radicals, preferably Cs-Cis alkyl radicals and mixtures thereof, more preferably C10, C12, C14, C16 and Cis-alkyl radicals and mixtures thereof, most preferably C12 and C14 alkyl radicals or a mixture thereof.
  • the HO-CH2- (CHOH) n -C- radical is one of one
  • Glucuronic acid in particular is to be mentioned as a preferred radical.
  • R 1 is preferably H or a short-chain alkyl radical, in particular methyl.
  • R 2 is preferably a long-chain alkyl radical, for example a Cs-Ci8 alkyl radical.
  • R 2 has the meanings given for formula (GB-IV).
  • a second essential component b) of the active substance-containing moldings is the polymeric gel former with a molar mass of 10,000 g / mol to 200,000 g / mol. It has proven to be particularly advantageous in relation to the production, packaging and handling of the shaped bodies to use polymeric gel formers with a molar mass of 10,000 to 40,000 g / mol.
  • the proportion by weight of polymeric forming agent b) in the total weight of active substance-containing shaped bodies is preferably from 0.01 to 15% by weight, more preferably from 0.1 to 12% by weight and in particular from 1 to 10% by weight.
  • Polymeric gel formers b) from the group of have proven to be technically advantageous
  • - Starch in particular potato starch, corn starch, wheat starch, pea starch or tapioca starch;
  • Suitable polyacrylates are homopolymers and copolymers of acrylic acid, in particular acrylic acid copolymers such as acrylic acid-methacrylic acid copolymers, and polysaccharides, especially heteropolysaccharides, and other customary polymer thickeners.
  • Suitable acrylic acid polymers are, for example, high molecular weight homopolymers of acrylic acid (INCI Carbomer) crosslinked with a polyalkenyl polyether, in particular an allyl ether of sucrose, pentaerythritol or propylene, which are also referred to as carboxyvinyl polymers.
  • a polyalkenyl polyether in particular an allyl ether of sucrose, pentaerythritol or propylene, which are also referred to as carboxyvinyl polymers.
  • Such polyacrylic acids are available inter alia from the company. BF Goodrich under the trade names Carbopof ®.
  • acrylic acid copolymers are the following acrylic acid copolymers: (i) Copolymers of two or more monomers from the group of acrylic acid, methacrylic acid and their simple, Esters (INCI Acrylates Copolymer) preferably formed with Ci- 4 alkanols, which include copolymers of methacrylic acid, butyl acrylate and methyl methacrylate (CAS 25035-69-2) or of butyl acrylate and methyl methacrylate (CAS 25852-37-3) and which are obtainable for example from the company Rohm & Haas under the trade names Aculyn ® and Acusol ®, and from Degussa (Goldschmidt) under the trade name Tego ® polymer.
  • acrylic acid copolymers include copolymers of methacrylic acid, butyl acrylate and methyl methacrylate (CAS 25035-69-2) or of butyl acrylate and methyl methacrylate (CAS 25852-37-3) and which are
  • (ii) crosslinked high molecular weight acrylic acid copolymers including, for example, the copolymers of Cio so-alkyl acrylates with one or more monomers from the group of acrylic acid, methacrylic acid and their simple esters, preferably formed with Cu alkanols, with an allyl ether of sucrose or pentaerythritol (INCI acrylates / C10-30 alkyl acrylate Crosspolymer) and which are obtainable, for example, by the company BF Goodrich under the trade name Carbopol ®. Suitable acrylate are also available under the trade name Sk ⁇ lan ® AT 120 and AT 120 Rheovis ® by the company BASF. If acrylic acid polymers and especially acrylic acid esters are used as polymeric thickeners, the pH is preferably more than 7, in particular at least 7.5, preferably 8 or more.
  • Preferred polyvinyl alcohols have a molecular weight of 10,000 g / mol to 150,000 g / mol, particularly preferably 10,000 g / mol to 80,000 g / mol and in particular 10,000 g / mol to 40,000 g / mol.
  • the degree of hydrolysis of preferred polyvinyl alcohols is 70 to 100 mol%, preferably 80 to 90 mol%, particularly preferably 81 to 89 mol% and in particular 82 to 88 mol%
  • the weight ratio of dibenzylidene sorbitol to polyvinyl alcohol is 10: 1 to 1:20, preferably 8: 1 to 1:15 and in particular 6: 1 to 1:10.
  • the moldings comprise an active substance c) as a third essential component. At least one active ingredient from the group of fragrances, enzymes and colorants, preferably at least one active ingredient from the group of fragrances, is preferably used as active ingredient c).
  • the proportion by weight of the active substance c), in particular the fragrance, in the total weight of the active substance-containing molding is preferably 0.1 to 20% by weight, more preferably 0.2 to 15% by weight and in particular 0.5 to 10% by weight. %.
  • a fragrance is a chemical substance that stimulates the sense of smell.
  • the chemical substance should be at least partially dispersible in the air, ie the fragrance should be at least slightly volatile at 25 ° C. If the fragrance is now very volatile, the odor intensity then quickly subsides again. If the volatility is lower, however, the odor impression is more lasting, ie it does not disappear as quickly.
  • the fragrance therefore has a melting point which is in the range from -100 ° C to 100 ° C, preferably from -80 ° C to 80 ° C, even more preferably from -20 ° C to 50 ° C, in particular from - 30 ° C to 20 ° C.
  • the fragrance has a boiling point which is in the range from 25 ° C. to 400 ° C., preferably from 50 ° C. to 380 ° C., more preferably from 75 ° C. to 350 ° C., in particular from 100 ° C. to 330 ° C.
  • a chemical substance should not exceed a certain molecular mass in order to function as a fragrance, since if the molecular mass is too high, the required volatility can no longer be guaranteed.
  • the fragrance has a molecular weight of 40 to 700 g / mol, more preferably 60 to 400 g / mol.
  • fragrances can also be used to mask unpleasant odors or to provide a non-odorous substance with a desired odor.
  • Individual fragrance compounds e.g. synthetic products of the ester, ether, aldehyde, ketone, alcohol and hydrocarbon type can be used as fragrances.
  • Fragrance compounds of the aldehyde type are, for example, adoxal (2,6,10-trimethyl-9-undecenal), anisaldehyde (4-methoxybenzaldehyde), cymal (3- (4-isopropyl-phenyl) -2-methylpropanal), ethylvanillin, florhydral ( 3- (3-isopropylphenyl) butanal), helional (3- (3,4-methylenedioxyphenyl) -2-methylpropanal), heliotropin, hydroxycitronellal, lauraldehyde, lyral (3- and 4- (4-hydroxy-4-methylpentyl) - 3- cyclohexene-1-carboxaldehyde), methylnonylacetaldehyde, Lilial (3- (4-tert-butylphenyl) -2-methylpropanal), phenylacetaldehyde, undecylenealdehyde, vanillin
  • Methylphenoxyacetaldehyde 2-methyl-3-phenyl-2-propen-1 -al, 3,5,5-trimethylhexanal, hexahydro-8,8-dimethyl-2-naphthaldehyde, 3-propyl-bicyclo- [2.2.1] - hept-5-en-2-carbaldehyde, 9-decenal, 3-methyl-5-phenyl-1-pentanal, methylnonylacetaldehyde, hexanal and trans-2-hexenal.
  • Fragrance compounds of the ketone type are, for example, methyl beta-naphthyl ketone, musk indanone (1, 2, 3,5,6, 7-hexahydro-1, 1, 2,3,3-pentamethyl-4H-inden-4-one), Tonalid (6-acetyl-1, 1, 2,4,4,7-hexamethyltetralin), alpha-damascone, beta-damascone, delta-damascone, iso-damascone, damascenone, methyl dihydrojasmonate, menthone, carvone, camphor, coavone (3 , 4, 5,6,6-pentamethylhept-3-en-2-one), fenchone, alpha-ionone, betalonone, gamma-methyl-ionone, fleuramone (2-heptylcyclopen-tanone), dihydrojasmone, cis-jasmone , iso-E-Super (1 -
  • Fragrance compounds of the alcohol type are, for example, 10-undecen-1-ol, 2,6-dimethylheptan-2-ol, 2-methyl-butanol, 2-methylpentanol, 2-phenoxyethanol, 2-phenylpropanol, 2-tert-butycyclohexanol, 3,5,5-trimethylcyclohexanol, 3-hexanol, 3-methyl-5-phenyl-pentanol, 3-octanol, 3-phenyl-propanol, 4-heptenol, 4-isopropyl-cyclohexanol, 4-tert.-butycyclohexanol, 6 , 8-dimethyl-2-nona-nol, 6-nonene-1 -ol, 9-decen-1 -ol, ⁇ -methylbenzyl alcohol, ⁇ -terpineol, amyl salicylate, benzyl alcohol, benzyl salicylate, ß-ter
  • Fragrance compounds of the ester type are, for example, benzyl acetate, phenoxyethyl isobutyrate, p-tert-butylcyclohexyl acetate, linalyl acetate, dimethylbenzylcarbinylacetate (DMBCA), phenylethyl acetate, Benzyl acetate, ethyl methylphenyl glycinate, allyl cyclohexyl propionate, styrallyl propionate, benzyl salicylate, cyclohexyl salicylate, floramate, melusate and jasmacyclate.
  • DMBCA dimethylbenzylcarbinylacetate
  • the ethers include, for example, benzyl ethyl ether and ambroxan.
  • the hydrocarbons mainly include terpenes such as limonene and pinene.
  • fragrances are preferably used, which together produce an appealing fragrance note.
  • a mixture of fragrances can also be referred to as perfume or perfume oil.
  • perfume oils can also contain natural fragrance mixtures, such as are available from vegetable sources.
  • the fragrances of vegetable origin include essential oils such as angelica root oil, anise oil, arnica flower oil, basil oil, bay oil, champaca flower oil, citrus oil, noble fir oil, noble fir cone oil, elemi oil, eucalyptus oil, fennel oil, spruce needle oil, guajun oil, gourd oil, gjajun oil, galbanum oil, gourd oil, gjajun oil , Ginger oil, iris oil, jasmine oil, kajeput oil, calamus oil, chamomile oil, camphor oil, kanaga oil, cardamom oil, cassia oil, pine needle oil, copaiva balsam oil, coriander oil, spearmint oil, caraway oil, cumin oil, labdanum oil, lavender oil, lemon linden oil, almond blossom oil , Muscatel oil, myrrh oil, clove oil, neroli oil, niaouli oil, olibanum oil, orange blossom oil, orange peel oil
  • Methyl anthranilic acid methyl ester p-methylacetophenone, methylchavikol, p-methylquinoline, methyl-betanaphthyl ketone, methyl-n-nonylacetaldehyde, methyl-n-nonyl ketone, muskon, beta-naphthol ethyl ether, beta-naphthol methyl ether, nerol, n-nonyl aldehyde, nonyl alcohol n-octylaldehyde, p-oxy-acetophenone, pentadecanolide, beta-phenylethyl alcohol, phenylacetic acid, pulegone, safrole, isoamyl salicylate, methyl salicylate, hexyl salicylate,
  • the active substance c in particular the fragrance substance.
  • at least part of the fragrance is used in encapsulated form (fragrance capsules), in particular in microcapsules.
  • the entire fragrance can also be used in encapsulated form.
  • the microcapsules can be water-soluble and / or water-insoluble microcapsules.
  • melamine-urea-formaldehyde microcapsules, melamine-formaldehyde microcapsules, urea-formaldehyde microcapsules or starch microcapsules can be used.
  • “Fragrance precursors” refers to compounds that only release the actual fragrance after chemical conversion / cleavage, typically through exposure to light or other environmental conditions, such as pH, temperature, etc. Such compounds are often referred to as fragrance storage substances or “pro-fragrance”.
  • the active ingredient c) is selected from the group of perfume oils and fragrance capsules.
  • the use of a combination of perfume oil and fragrance capsule is very particularly preferred.
  • the active ingredient-containing shaped bodies described in this application contain at least one further component d) as an essential component.
  • Suitable solvents are selected from the group consisting of ethanol, n-propanol, i-propanol, butanols, glycol, propanediol, butanediol, methylpropanediol, glycerol, propylene carbonate, diglycol, propyl diglycol, butyl diglycol, hexylene glycol, diethylene glycol ethyl ether, diethylene glycol methyl ether, diethylene glycol methyl ether, diethylene glycol ether, diethylene glycol , Diethylene glycol n-butyl ether acetate, ethylene glycol propyl ether, ethylene glycol n-butyl ether, ethylene glycol hexyl ether, ethylene glycol n-butyl ether acetate, triethylene glycol, triethylene glycol methyl ether, triethylene glycol ethyl ether, triethylene glycol ether,
  • a first group of particularly preferred active substance-containing moldings is characterized in that the solvent d) is a solvent from the group of polyalkylene glycols liquid at room temperature (20 ° C), in particular polyalkylene glycols liquid at room temperature (20 ° C), particularly preferably from the PEG group 200 and PEG 400 includes.
  • a second group of particularly preferred active substance-containing moldings is characterized in that the solvent d) is a solvent from the group of organic polyols liquid at room temperature (20 ° C.), in particular diols liquid at room temperature (20 ° C.), particularly preferably from the group 2-methyl-1,3-propanediol (MPDiol) and 3-methyl-1,3-butanediol (isopentyldiol).
  • the solvent d) is a solvent from the group of organic polyols liquid at room temperature (20 ° C.), in particular diols liquid at room temperature (20 ° C.), particularly preferably from the group 2-methyl-1,3-propanediol (MPDiol) and 3-methyl-1,3-butanediol (isopentyldiol).
  • compositions d) glycerol or triacetin or water include as solvents d) glycerol or triacetin or water.
  • solvents have proven to be technically particularly advantageous, in particular the combination of water and 3-methyl-1,3-butanediol (isopentyldiol), but in particular the combination of water, glycerol and 3-methyl-1,3-butanediol are called.
  • the proportion by weight of solvent d) in the total weight of active substance-containing shaped bodies is preferably 10 to 98% by weight, particularly preferably 40 to 97% by weight and in particular 60 to 96% by weight.
  • particularly preferred active substance-containing shaped bodies have a weight of 0.2 to 20 g and comprise, based on its total weight
  • the active substance-containing shaped bodies preferably comprise less than 10% by weight, preferably less than 8% by weight, particularly preferably less than 4% by weight and in particular less than 1% by weight of surfactant. Very particularly preferred active substance-containing moldings do not comprise any surfactant.
  • compositions for tablets containing active substances can be found in the tables below (data in% by weight based on the total weight of the tablets).
  • the active substance-containing moldings in these tables preferably comprise less than 10% by weight, more preferably less than 8% by weight, particularly preferably less than 4% by weight and in particular less than 1% by weight of surfactant. It is also preferred if the shaped bodies have a weight of 0.2 to 20 g.
  • the active substance-containing shaped body preferably has a storage modulus G 'of 10 3 Pascal to 10 8 Pascal, more preferably 10 4 Pascal to 10 6 Pascal, measured with a rotational rheometer using a cone-plate measuring system with a diameter of 40 mm and an opening angle of 2 ° a temperature of 20 ° C.
  • the rheological characterization is carried out in the context of this invention with a rotational rheometer, for example from TA-Instruments, type AR G2, from Malvern "Kinexus", using a cone-plate measuring system with a diameter of 40 mm and a 2 ° opening angle at a temperature of 20 ° C performed. These are shear stress controlled rheometers. The determination can, however, also be carried out with other instruments or measurement geometries with comparable specifications.
  • the measurement of the storage modulus (abbreviation: G mix) and the loss modulus (abbreviation: G “) (each unit: Pa) was carried out with the equipment described above in an experiment with oscillating deformation.
  • the linear viscoelastic range is first determined in a “stress sweep experiment”.
  • the shear stress amplitude is increased at a constant frequency of e.g. 1 Hz.
  • the modules G ‘and G“ are plotted in a double logarithmic plot.
  • the shear stress amplitude or the (resulting) deformation amplitude can optionally be plotted on the x-axis.
  • the kink point is expediently determined by applying tangents to the two curve sections.
  • the corresponding deformation amplitude or shear stress amplitude is usually referred to as “critical deformation” or “critical shear stress”.
  • a frequency ramp e.g. between 0.01 Hz and 10 Hz, is run at a constant deformation amplitude.
  • the deformation amplitude must be chosen so that it is in the linear range, i.e. below the critical deformation mentioned above. In the case of the compositions according to the invention, a deformation amplitude of 0.1% has proven to be suitable.
  • the modules G ‘and G“ are plotted against the frequency in a double logarithmic plot.
  • Preferred optional constituents include tablets containing active ingredients, dyes, preservatives or bitter substances.
  • they preferably comprise at least one dye.
  • the shaped bodies comprise at least one water-soluble dye, particularly preferably a water-soluble polymer dye.
  • Preferred dyes should have high storage stability and insensitivity to the other ingredients of the detergents or cleaning agents and to light and not have any pronounced substantivity towards textile fibers in order not to stain them.
  • the dye is a common dye that can be used for various detergents or cleaning agents.
  • the dye is preferably selected from Acid Red 18 (CI 16255), Acid Red 26, Acid Red 27, Acid Red 33, Acid Red 51, Acid Red 87, Acid Red 88, Acid Red 92, Acid Red 95, Acid Red 249 ( CI 18134), Acid Red 52 (CI 45100), Acid Violet 126, Acid Violet 48, Acid Violet 54, Acid Yellow 1, Acid Yellow 3 (CI 47005), Acid Yellow 1 1, Acid Yellow 23 (CI 19140), Acid Yellow 3, Direct Blue 199 (CI 74190), Direct Yellow 28 (CI 19555), Food Blue 2 (CI 42090), Food Blue 5: 2 (CI 42051: 2), Food Red 7 (01 16255), Food Yellow 13 (CI 47005), Food Yellow 3 (C1 15985), Food Yellow 4 (C1 19140), Reactive Green 12, Solvent Green 7 (CI 59040).
  • Particularly preferred dyes are water-soluble acid dyes, for example Food Yellow 13 (Acid Yellow 3, CI 47005), Food Yellow 4 (Acid Yellow 23, CI 19140), Food Red 7 (Acid Red 18, CI 16255), Food Blue 2 (Acid Blue 9, CI 42090), Food Blue 5 (Acid Blue 3, CI 42051), Acid Red 249 (CI 18134), Acid Red 52 (CI 45100), Acid Violet 126, Acid Violet48, Acid Blue 80 (01 61585), Acid Blue 182, Acid Blue 182, Acid Green 25 (CI 61570), Acid Green 81.
  • Food Yellow 13 Acid Yellow 3, CI 47005
  • Food Yellow 4 Acid Yellow 23, CI 19140
  • Food Red 7 Acid Red 18, CI 16255
  • Food Blue 2 Acid Blue 9, CI 42090
  • Food Blue 5 Acid Blue 3, CI 42051
  • Acid Red 249 CI 18134
  • Acid Red 52 CI 45100
  • Acid Violet 126 Acid Violet48
  • Acid Blue 80 01 61585
  • Acid Blue 182 Acid Blue 18
  • Water-soluble direct dyes for example Direct Yellow 28 (CI 19555), Direct Blue 199 (CI 74190) and water-soluble reactive dyes, for example Reactive Green 12, and the dyes Food Yellow 3 (CI 15985), Acid Yellow 184 are also preferably used.
  • Aqueous dispersions of the following pigment dyes Pigment Black 7 (CI 77266), Pigment Blue 15 (CI 74160), Pigment Blue 15: 1 (CI 74160), Pigment Blue 15: 3 (CI 74160), Pigment Green 7 are also preferably used (CI 74260), Pigment Orange 5, Pigment Red 1 12 (CI 12370), Pigment Red 1 12 (CI 12370), Pigment Red 122 (CI 73915), Pigment Red 179 (CI 71 130), Pigment Red 184 (CI 12487 ), Pigment Red 188 (CI 12467), Pigment Red 4 (CI 12085), Pigment Red 5 (CI 12490), Pigment Red 9, Pigment Violet 23 (CI 51319), Pigment Yellow 1 (CI 28 1 1680), Pigment Yellow 13 (CI 21 100), Pigment Yellow 154, Pigment Yellow 3 (CI 1 1710), Pigment Yellow 74, Pigment Yellow 83 (CI 21 108), Pigment Yellow 97.
  • pigment Yellow 1 (CI 1 1680), Pigment Yellow 3 (C1 1 1710), Pigment Red 1 12 (CI 12370), Pigment Red 5 (CI 12490), Pigment Red 181 (CI 73360), Pigment Violet 23 (CI 51319), Pigment Blue 15: 1 (CI 7 4160), Pigment Green 7 (CI 74260), Pigment Black 7 (CI 77266).
  • water-soluble polymer dyes for example Liquitint, Liquitint Blue HP, Liquitint Blue MC, Liquitint Blue 65, Liquitint Cyan 15, Liquitint Patent Blue, Liquitint Violet 129, Liquitint Royal Blue, Liquitint Experimental Yellow 8949-43, Liquitint Green HMC, Liquitint Yellow LP, Liquitint Yellow II and mixtures thereof are used.
  • the group of very particularly preferred dyes includes Acid Blue 3, Acid Yellow 23, Acid Red 33, Acid Violet 126, Liquitint Yellow LP, Liquitint Cyan 15, Liquitint Blue HP and Liquitint Blue MC.
  • the proportion by weight of the dye in the total weight of the active substance-containing shaped bodies is preferably from 0.001 to 0.5% by weight, more preferably from 0.002 to 0.2% by weight.
  • bitter substances primarily serves to avoid oral ingestion of the tablets containing active substances.
  • Preferred moldings contain at least one bitter substance in an amount of 0.0001 to 0.1% by weight, based on the total weight of the composition. Quantities from 0.0005 to 0.02% by weight are particularly preferred. According to the present invention, those bitter substances are particularly preferred which are soluble in water at 20 ° C. to the extent of at least 5 g / l. With regard to an undesirable interaction with the fragrance components also contained in the composition, in particular a change in the fragrance note perceived by the consumer, the ionic bitter substances have proven to be superior to the non-ionic ones. Ionic bitter substances consisting of organic cation (s) and organic anion (s) are consequently preferred for the composition according to the invention.
  • the at least one bitter substance is therefore an ionogenic bitter substance.
  • quaternary ammonium compounds which contain an aromatic group both in the cation and in the anion are eminently suitable.
  • the at least one bitter substance is therefore a quaternary ammonium compound.
  • a suitable quaternary ammonium compound is, for example, without restriction, benzyldiethyl ((2,6-xylylcarbamoyl) methyl) ammonium benzoate, which is commercially available, for example, under the trademarks Bitrex® and Indige-stin®. This compound is also known as Denatonium Benzoate.
  • the at least one bitter substance is benzyl diethyl ((2,6-xylylcarbamoyl) methyl) ammonium benzoate (Bitrex®). If Bitrex® is used, most amounts up to 0.002% by weight are preferred. The information is based on the active substance content.
  • This application also relates to a method for producing a molded body, comprising the steps
  • step i) the first preparation in step a) and / or
  • an active ingredient is added to the mixture of the first preparation and the second preparation in step c).
  • the first preparation in step a) has a temperature between 30.degree. C. and 180.degree. C., preferably between 60.degree. C. and 160.degree.
  • the second preparation in step b) preferably has a temperature between 30.degree. C. and 90.degree. C., in particular between 40.degree. C. and 70.degree. C., for the same technical reasons.
  • the mixture is preferably introduced into a mold in step d).
  • the shape can be a permanent mold or a “lost” shape (Mughal technique).
  • Durable casting molds are preferred. These casting molds are preferably made of metallic or polymeric materials. The use of polymeric materials for the casting mold or any coating on the casting mold is preferred.
  • the casting mold can be open or closed on one side, casting molds open on one side being preferred. If casting molds that are open on one side are used, the resulting moldings have a flat top side corresponding to the open top side if the viscosity of the casting compound is sufficiently low.
  • the geometry of the casting mold (and thus of the molded body produced by the process) is variable over a wide range. It not only influences the later product aesthetics but also the manufacturability of the molded body and its later dissolution behavior.
  • the term processability includes, for example, the solidification behavior of the molded body, its detachability from the casting mold and its transportability and storability.
  • the mixture is portioned in step d) by dripping onto a surface and then shaped on this surface.
  • it is particularly preferred to portion the mixture in step d) by dropping it onto a steel belt using a drop former with a rotating, perforated outer drum and then to shape it on this surface.
  • the mixture is preferably cooled in step d).
  • a method for cleaning a textile surface using a molded body described above is a further subject of this application.
  • Active substance-containing moldings with a weight of 0.2 to 20 g, comprising
  • Active substance-containing shaped body according to item 1 wherein the shaped body has a weight of 0.2 to 10 g, preferably 0.5 to 5 g.
  • the weight ratio of low molecular weight gel former to polymeric gel former being 10: 1 to 1:20, preferably 8: 1 to 1:15 and in particular 6: 1 to 1:10.
  • the low molecular weight gel former having a molar mass of 200 g / mol to 2000 g / mol, preferably from 200 g / mol to 1000 g / mol.
  • Active substance-containing shaped body according to one of the preceding points, wherein the shaped body, based on its total weight, has a proportion by weight of low molecular weight component a) of 0.01 to 15% by weight, preferably 0.1 to 10% by weight and in particular 1 to 4 wt .-%.
  • the low-molecular gelling agent is a) selected from the group of Benzylidenalditol compounds, hydroxystearic acid, hydrogenated castor oil, Diarylamidocystin compound, N- (C8-C 24) - Hydrocarbylglyconamid, diketopiperazine compound, 2-methyl-acrylic acid-2-ureido-ethyl ester and mixtures thereof.
  • Active substance-containing molded body according to one of the preceding points the polymeric gel former having a molar mass of 10,000 to 40,000 g / mol.
  • Active substance-containing shaped body according to one of the preceding points wherein the shaped body, based on its total weight, has a weight fraction of polymeric forming agent b) of 0.01 to 15% by weight, preferably 0.1 to 12% by weight and in particular from 1 to 10 Has wt .-%.
  • Active substance-containing shaped body according to one of the preceding points, wherein the polymeric gel former b) is selected from the group of
  • Celluloses and cellulose derivatives especially methyl cellulose
  • Starch especially potato starch, corn starch, wheat starch, pea starch or
  • Active substance-containing shaped body according to one of the preceding points wherein the polymeric gel former b) is selected from the group of polyvinyl alcohols. Active substance-containing molded body according to one of the preceding points, the weight ratio of dibenzylidene sorbitol to polyvinyl alcohol being 10: 1 to 1:20, preferably 8: 1 to 1:15 and in particular 6: 1 to 1:10. Active substance-containing shaped body according to one of the preceding points, wherein the shaped body, based on its total weight, has a weight fraction of active substance of 0.1 to 20% by weight, preferably 0.2 to 15% by weight and in particular 0.5 to 10% by weight .-% having.
  • Active substance-containing shaped body according to one of the preceding points wherein the shaped body comprises as active substance c) at least one active substance from the group of fragrances, enzymes and colorants. Active substance-containing shaped body according to one of the preceding points, wherein the active substance c) is encapsulated.
  • the solvent d) being selected from the group consisting of ethanol, n-propanol, i-propanol, butanols, glycol, propanediol, butanediol, methylpropanediol, glycerol, propylene carbonate, diglycol, propyldiglycol, butyldiglycol, hexylene glycol, Diethylene glycol ethyl ether, diethylene glycol methyl ether, diethylene glycol n-butyl ether, Diethylene glycol hexyl ether, diethylene glycol n-butyl ether acetate, ethylene glycol propyl ether, ethylene glycol n-butyl ether, ethylene glycol hexyl ether, ethylene glycol n-butyl ether acetate, ethylene glycol propyl ether, ethylene glycol n-butyl ether, ethylene glycol hexyl ether, ethylene glyco
  • the solvent d) is a solvent from the group of polyalkylene glycols liquid at room temperature (20 ° C), in particular the polyalkylene glycols liquid at room temperature (20 ° C), particularly preferably from the group PEG 200 and PEG 400 includes.
  • Active substance-containing molded body according to one of the preceding points wherein the solvent d) is a solvent from the group of organic polyols liquid at room temperature (20 ° C.), in particular the diols liquid at room temperature (20 ° C.), particularly preferably from the 2-methyl group -1, 3-propanediol (MPDiol) and 3-methyl-1,3-butanediol (isopentyldiol) includes.
  • Active substance-containing shaped body according to one of the preceding points, wherein d) comprises triacetin as the solvent.
  • Active substance-containing shaped body according to one of the preceding points, the shaped body having, based on its total weight, a weight fraction of solvent d) of 10 to 98% by weight, preferably 40 to 97% by weight and in particular 60 to 96% by weight .
  • Active substance-containing moldings with a weight of 0.2 to 20 g, based on its total weight
  • Active substance-containing shaped body according to one of the preceding points comprising less than 10% by weight, preferably less than 8% by weight, particularly preferably less than 4% by weight and in particular less than 1% by weight surfactant. Active substance-containing shaped body according to one of the preceding points, wherein the shaped body does not comprise a surfactant.
  • Active substance-containing shaped body according to one of the preceding points the shaped body having a storage module G '(rotational rheometer using a cone-plate measuring system with a diameter of 40 mm and a 2 ° opening angle at a temperature of 20 ° C) of 10 3 Pascal to 10 8 Pascal, preferably 10 4 pascals to 10 6 pascals.
  • Active substance-containing shaped body according to one of the preceding points the shaped body further comprising at least one dye, preferably at least one water-soluble dye, particularly preferably a water-soluble polymer dye.
  • Active substance-containing shaped body according to one of the preceding points wherein the shaped body further comprises at least one bitter substance.
  • Active substance-containing shaped body according to one of the preceding points the shaped body being translucent and / or transparent, particularly preferably transparent.
  • Washing or cleaning agent comprising at least one active substance-containing shaped body according to one of the preceding points.
  • step i) the first preparation in step a) and / or
  • an active substance preferably a fragrance
  • the first preparation in step a) has a temperature between 30 ° C and 180 ° C, preferably between 60 ° C and 160 ° C.
  • the second preparation in step b) has a temperature between 30 ° C and 90 ° C, preferably between 40 ° C and 70 ° C.
  • the mixture is introduced into a mold in step d).
  • the mixture being portioned in step d) by dripping onto a surface and then being shaped on this surface.
  • Method according to one of the preceding points the mixture being portioned in step d) by dripping onto a steel belt by means of a drop former with a rotating, perforated outer drum and then being shaped on this surface.
  • Method according to one of the preceding points wherein the mixture is cooled in step d). Process for cleaning a textile surface using a shaped body according to one of the preceding points.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne des corps moulés contenant des agents actifs ayant un poids de 0,2 à 20 g, contenant a) au moins un agent gélifiant de faible masse moléculaire, ayant une masse molaire de 2000 g/mol ; b) au moins un agent gélifiant polymère ayant une masse molaire de 10000 g/mol à 200000 g/mol ; c) au moins un agent actif ; d) au moins un solvant, et un procédé de fabrication de ces corps moulés.
PCT/EP2020/065010 2019-07-23 2020-05-29 Corps moulés contenant des agents actifs et procédé de fabrication de ceux-ci WO2021013412A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20730225.8A EP4004173A1 (fr) 2019-07-23 2020-05-29 Corps moulés contenant des agents actifs et procédé de fabrication de ceux-ci

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102019210895.4 2019-07-23
DE102019210895.4A DE102019210895A1 (de) 2019-07-23 2019-07-23 Aktivstoffhaltige Formkörper und Verfahren zu deren Herstellung

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WO2021013412A1 true WO2021013412A1 (fr) 2021-01-28

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EP (1) EP4004173A1 (fr)
DE (1) DE102019210895A1 (fr)
WO (1) WO2021013412A1 (fr)

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CN115362245A (zh) * 2022-07-08 2022-11-18 广州洁生日化有限公司 一种环保型洗涤片及其制备方法及制片设备

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US20050107273A1 (en) * 2003-10-28 2005-05-19 Colgate-Palmotive Company Bar soap composition with reduced bar wear properties
US20140186412A1 (en) * 2012-12-28 2014-07-03 The Dial Corporation Detergent compositions dispersed in personal care products comprising a sorbent carrier
DE102017223460A1 (de) * 2017-12-20 2019-06-27 Henkel Ag & Co. Kgaa Viskoselastische, festförmige Tensidzusammensetzung mit hohem Tensidgehalt

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ASHLAND: "Klucel RTM hydroxypropylcellulose - physical and chemical properties", 1 January 2012 (2012-01-01), XP055142638, Retrieved from the Internet <URL:http://www.ashland.com/Ashland/Static/Documents/ASI/PC_11229_Klucel_HPC.pdf> [retrieved on 20140925] *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115362245A (zh) * 2022-07-08 2022-11-18 广州洁生日化有限公司 一种环保型洗涤片及其制备方法及制片设备
CN115362245B (zh) * 2022-07-08 2023-08-18 广州洁生日化有限公司 一种洗涤片及其制备方法及制片设备

Also Published As

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EP4004173A1 (fr) 2022-06-01
DE102019210895A1 (de) 2021-01-28

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