WO2021012460A1 - 一种预防和治疗鳗鲡细菌性肠炎的药物及其制备方法 - Google Patents

一种预防和治疗鳗鲡细菌性肠炎的药物及其制备方法 Download PDF

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WO2021012460A1
WO2021012460A1 PCT/CN2019/115496 CN2019115496W WO2021012460A1 WO 2021012460 A1 WO2021012460 A1 WO 2021012460A1 CN 2019115496 W CN2019115496 W CN 2019115496W WO 2021012460 A1 WO2021012460 A1 WO 2021012460A1
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medicine
raw materials
eel
preventing
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吴少坤
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集美大学
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Definitions

  • the invention belongs to the technical field of prevention and treatment of artificial breeding aquatic diseases, and specifically refers to a medicine for preventing and curing eel bacterial enteritis and a preparation method thereof.
  • Eel is one of the most important farmed economic fish in China.
  • environmental stress has intensified, and breeding diseases have become more and more serious, which has caused huge economic losses to the eel farming industry.
  • bacterial diseases are more serious.
  • chemical drugs such as chloramphenicol and norfloxacin
  • broad-spectrum antibiotics are mainly used for prevention and treatment of broad-spectrum antibiotics.
  • the pond When the fry is selected and transferred to a new pond, the pond is immersed in 0.1% ⁇ 0.7% salt water, and the pond is regularly disinfected, with 25 ⁇ 30 mg/L formalin solution, Or spray the pond with 0.1 ⁇ 0.2 mg/L methyl blue to prevent eel disease; when eel develops disease, raise the pond water temperature above 25°C, and wash with 2 ⁇ 3 mg/L nitrofurazone, or use 0.1 ⁇ 0.2 mg/L malachite green immersion to treat diseased eels.
  • Chinese herbal medicine has many advantages such as naturalness, nutrition, immune function enhancement, anti-stress, anti-microbial, repelling (killing) insects, two-way regulation, small toxic and side effects, and resistance to drug resistance. Therefore, the application of Chinese herbal medicines in the prevention and treatment of fish diseases has attracted more and more attention.
  • the medicine is made by scientifically matching Chinese herbal medicines and conventional materials, which can prevent and treat the bacterial enteritis of eels with high treatment efficiency.
  • One of the technical problems to be solved by the present invention is to provide a medicine for preventing and treating eel bacterial enteritis, which can prevent and treat eel bacterial enteritis.
  • the medicine is naturally non-toxic and side effects, does not cause water pollution, and has high treatment efficiency.
  • the second technical problem to be solved by the present invention is to provide a preparation method for the prevention and treatment of eel bacterial enteritis.
  • the method is simple and effective, and the prepared drug has no side effects, does not cause water pollution, and can prevent and treat eels. Bacterial enteritis, high treatment efficiency.
  • the present invention is realized as follows:
  • a medicine for the prevention and treatment of eel bacterial enteritis specifically including the following raw materials and their component ratios:
  • a method for preparing a medicine for preventing and treating bacterial enteritis of eel includes the following steps:
  • Step S1 Weigh castor bean, rapeseed, and soybean raw materials as claimed in claim 1 or 2 by mass to remove impurities, and then use a pulverizer to pulverize the raw materials separately, and put the pulverized raw materials into a container for use;
  • Step S2 Weigh the chicken meat according to claim 1 or 2, and use a meat grinder to grind it for use;
  • Step S3 Pour the pulverized raw materials in step S1 and the mashed chicken in step S2 into a blender and stir. During the stirring process, add brown sugar, and get a preventive agent after the stirring is uniform;
  • Step S4 Weigh the garlic, Bupleurum, Houttuynia cordata, Astragalus, and Atractylodes macrocephala according to claim 1 or 2, respectively, crush them, pour them into a mixer and stir evenly to obtain a therapeutic agent;
  • Step S5 the preventive medicine obtained in step S3 and the therapeutic agent obtained in step S4 are stirred and mixed, and granulated by a screw granulator to obtain the medicine.
  • the method of using the medicine obtained in step S5 is: mixing and feeding with feed, wherein the ratio of the medicine to the feed is 1:30-50.
  • the present invention provides a medicine for preventing and treating eel bacterial enteritis.
  • the medicine components are all natural materials, without other toxic and side effects, and will not cause water pollution.
  • the ingredients of the medicine are preventive and therapeutic agents.
  • the castor bean and rapeseed in the preventive agents contain more lipase, which has a good effect on the treatment and prevention of eel bacterial enteritis.
  • soybeans and chicken are rich in The amino acids can stimulate the eating of eels, avoiding the poor treatment effect caused by the lack of eating of eels during the onset of disease; garlic, Bupleurum, Houttuynia cordata, Astragalus, and Atractylodes macrocephala are all natural Chinese medicinal materials, which have sterilization, antibacterial and enhancement The effect of immunity.
  • a medicine for the prevention and treatment of eel bacterial enteritis specifically including the following raw materials and their component ratios:
  • the preparation method includes the following steps:
  • Step S1 Weigh the raw materials of castor bean, rapeseed, and soybeans as described above, remove impurities, and then use a pulverizer to pulverize the raw materials and put them into containers for use;
  • Step S2 Weigh the chicken meat as described above, use a meat grinder to grind it, and set aside;
  • Step S3 Pour the pulverized raw materials in step S1 and the minced chicken in step S2 into a blender and stir. During the stirring process, add brown sugar, and get a preventive agent after the stirring is even;
  • Step S4 Weigh the garlic, Bupleurum, Houttuynia, Astragalus, and Atractylodes macrocephalae in the above-mentioned mass parts, crush them separately, pour them into a blender and stir evenly to obtain a therapeutic agent;
  • Step S5 the preventive medicine obtained in step S3 and the therapeutic agent obtained in step S4 are stirred and mixed, and granulated by a screw granulator to obtain the medicine.
  • the method of use of the medicine is: mixed with feed, and the ratio of medicine to feed is 1:40.
  • a medicine for the prevention and treatment of eel bacterial enteritis specifically including the following raw materials and their component ratios:
  • the preparation method includes the following steps:
  • Step S1 Weigh the raw materials of castor bean, rapeseed, and soybeans as mentioned above, remove impurities, and then use a pulverizer to pulverize the raw materials, and put the pulverized raw materials into a container for use;
  • Step S2 Weigh the chicken meat as described above, use a meat grinder to grind it, and set aside;
  • Step S3 Pour the pulverized raw materials in step S1 and the minced chicken in step S2 into a blender and stir. During the stirring process, add brown sugar, and get a preventive agent after the stirring is even;
  • Step S4 Weigh the garlic, Bupleurum, Houttuynia, Astragalus, and Atractylodes macrocephalae in the above-mentioned mass parts, crush them separately, pour them into a blender and stir evenly to obtain a therapeutic agent;
  • Step S5 the preventive medicine obtained in step S3 and the therapeutic agent obtained in step S4 are stirred and mixed, and granulated by a screw granulator to obtain the medicine.
  • the method of use of the drug is: mixed with feed, and the ratio of drug to feed is 1:30.
  • a medicine for the prevention and treatment of eel bacterial enteritis specifically including the following raw materials and their component ratios:
  • the preparation method includes the following steps:
  • Step S1 Weigh the raw materials of castor bean, rapeseed, and soybeans as mentioned above, remove impurities, and then use a pulverizer to pulverize the raw materials, and put the pulverized raw materials into a container for use;
  • Step S2 Weigh the chicken meat as described above, use a meat grinder to grind it, and set aside;
  • Step S3 Pour the pulverized raw materials in step S1 and the mashed chicken in step S2 into a blender and stir. During the stirring process, add brown sugar, and get a preventive agent after the stirring is uniform;
  • Step S4 Weigh the garlic, Bupleurum, Houttuynia, Astragalus, and Atractylodes macrocephalae in the above-mentioned mass parts, crush them separately, pour them into a blender and stir evenly to obtain a therapeutic agent;
  • Step S5 the preventive medicine obtained in step S3 and the therapeutic agent obtained in step S4 are stirred and mixed, and granulated by a screw granulator to obtain the medicine.
  • the method of using the drug is to mix it with feed, and the ratio of drug to feed is 1:50.
  • Bupleurum It is the dried root of Bupleurum vulgare or Bupleurum angustifolia in the Umbelliferae family. It is bitter in nature and tastes slightly cold, and belongs to the liver and gallbladder channels. It has the effects of relieving the surface, soothing the liver and promoting yang. Used for fever, cold and heat, malaria, stagnation of liver and qi, etc.
  • Houttuynia cordata It is the dry above-ground part of Saururus chinensis family plant, which is pungent in taste, cold in nature, and returns to the lung meridian.
  • Astragalus It is the root of Astragalus mongolia in legumes. The functions and indications are: invigorating qi and consolidating the surface, supporting toxin and purging pus, diuresis, and promoting body fluid. Used for qi deficiency and fatigue, sore sores will not heal for a long time.
  • Atractylodes macrocephala is a perennial herb of the Compositae family. Its medicinal function is a medicine for spleen movement. It has a bitter, warm and pungent nature and has the effects of drying dampness, turbidity and pain relief.
  • Feeding the eel with the drug-mixed feed of the present invention can effectively enhance the immunity of the eel. It is found through experiments that the traditional disease prevention and control methods can increase the weight of eels by 7 grams per month, and the incidence rate reaches 7%. However, feeding eels with the drug-mixed feed of the present invention can gain 19 grams per month, and the incidence rate is reduced to 0.5 %. For eels that have suffered from enteritis, the drug-mixed feed of the present invention is used to feed the eels, and the cure rate reaches 98%. Therefore, the medicine of the present invention can effectively prevent and treat the bacterial enteritis of the eel, enhance the immunity of the eel, and effectively promote the growth of the eel.

Abstract

一种预防和治疗鳗鲡细菌性肠炎的药物，包括以下重量份的原料：蓖麻子10～15份，油菜籽12～14份，大豆9～12份，鸡肉5～8份，红糖12～14份，大蒜15～18份，柴胡18～21份，鱼腥草16～20份，黄芪20～23份，白术18～24份。将蓖麻子、油菜籽、大豆分别粉碎，将鸡肉绞碎，混合并搅拌，过程中加入红糖，均匀后得预防药剂；将大蒜、柴胡、鱼腥草、黄芪、白术分别粉碎，搅拌均匀，得到治疗药剂；预防药剂和治疗药剂搅拌混合，通过螺杆造粒机造粒即得。

Description

一种预防和治疗鳗鲡细菌性肠炎的药物及其制备方法 技术领域
本发明属于人工养殖水产疾病防治技术领域，具体是指一种预防和治疗鳗鲡细菌性肠炎的药物及其制备方法。
 背景技术
鳗鲡是中国最重要的养殖经济鱼类之一。近年来，随着养鳗业集约化程度加深，环境胁迫加剧，养殖病害日趋严重，给鳗鲡养殖业造成了巨大的经济损失。其中，细菌性疾病危害较为严重。目前生产上主要以广谱抗生素为主的化学药物（如氯霉素、氟哌酸等）进行防治，它们虽然具有疗效显著、治疗周期短等优点，但是大量使用不仅加剧水环境的恶化，提高病原菌的耐药性，还可抑制鳗鲡生长，损伤鳗鲡肝脏等内脏器官机能，更重要的是，导致药物在产品中的残留超标，降低产品质量。除此之外，还有其他的防治技术，在鱼苗选别后转投新池时，用0.1%~0.7%盐水浸洗鱼池，池塘定期消毒，用25~30毫克/升福尔马林溶液、或用0.1~0.2毫克/升甲基蓝泼洒池塘，对鳗鲡疾病进行预防；当鳗鲡发生疾病时，把发病池塘水温提高到25℃以上，用2~3毫克/升呋喃西林浸洗，或用0.1~0.2毫克/升孔雀石绿浸洗，对发病的鳗鲡进行治疗。这些防治技术，存在一定弊端：（1）鳗鲡进食减少，影响鳗鲡幼苗的生长，会使治疗效果进一步减弱，防治效果一般；（2）治疗成本大，费时费力；（3）对养殖用水量需求过大，造成水资源浪费，不符合环保要求；（4）用药过后残留的药物，易造成水体的污染，不利于环境的保护。
因此，合理开发水产药物已成为水产疾病研究的重要问题。中草药类药物具有天然性、营养性、增强免疫功能、抗应激、抗微生物、驱(杀)虫、双向调节、毒副残留小、不易产生抗药性等多种优点。所以，中草药类药物在鱼病防治上的应用越来越受到重视。本药物由中草药与常规物料科学配比制作而成，可以防治鳗鲡的细菌性肠炎，治疗效率高。
 技术问题
本发明所要解决的技术问题之一在于提供一种用于预防和治疗鳗鲡细菌性肠炎的药物，可以防治鳗鱼的细菌性肠炎。该药物天然无毒副作用，不会造成水体污染，治疗效率高。
本发明所要解决的技术问题之二在于提供一种用于预防和治疗鳗鲡细菌性肠炎的药物的制备方法，该方法简单有效，制备的药物天然无副作用，不会造成水体污染，可以防治鳗鱼的细菌性肠炎，治疗效率高。
 技术解决方案
本发明是这样实现的：
一种用于预防和治疗鳗鲡细菌性肠炎的药物，具体包括以下原料及其组分比：
蓖麻子10~15份，油菜籽12~14份，大豆9~12份，鸡肉5~8份，红糖12~14份，大蒜15~18份，柴胡18~21份，鱼腥草16~20份，黄芪20~23份，白术18~24份。
进一步地，所述原料及其组分比为：
蓖麻子12份，油菜籽13份，大豆10份，鸡肉7份，红糖8份，大蒜18份，柴胡20份，鱼腥草19份，黄芪22份，白术20份。
一种用于预防和治疗鳗鲡细菌性肠炎的药物的制备方法，包括如下步骤：
步骤S1：称取如权利要求1或2所述的质量份的蓖麻子、油菜籽、大豆原料，去除杂质，然后使用粉碎机将原料分别粉碎，粉碎后的原料放入容器中，备用；
步骤S2：称取如权利要求1或2所述的质量份的鸡肉，使用绞肉机绞碎，备用；
步骤S3：将步骤S1粉碎后的原料和步骤S2搅碎后的鸡肉倒入搅拌器中搅拌，在搅拌过程中，加入红糖，搅拌均匀后得预防药剂；
步骤S4：称取如权利要求1或2所述的质量份的大蒜、柴胡、鱼腥草、黄芪、白术，分别粉碎，倒入搅拌器中搅拌均匀，得到治疗药剂；
步骤S5：将步骤S3得到的预防药剂和步骤S4得到的治疗药剂进行搅拌混合，并通过螺杆造粒机造粒，即得到药物。
进一步地，所述步骤S5得到的药物的使用方法为：与饲料混合投喂，其中该药物与饲料的比例为：1：30~50。
 有益效果
本发明的优点在于：本发明提供了一种用于预防和治疗鳗鲡细菌性肠炎的药物，药物的成份均为天然物料，无其他毒副作用，不会造成水体污染。药物成分为预防药剂和治疗药剂，预防药剂中的蓖麻子和油菜籽中含有较多的脂肪酶，对鳗鲡细菌性肠炎的治疗和预防都有很好的作用；同时大豆、鸡肉中富含丰富的氨基酸可刺激鳗鲡的进食，避免了鳗鲡在发病期进食少而引起的治疗效果不佳；大蒜、柴胡、鱼腥草、黄芪、和白术均为天然中药材，具有杀菌、抑菌、增强免疫力的效果。
 本发明的实施方式
实施例一：
一种用于预防和治疗鳗鲡细菌性肠炎的药物，具体包括以下原料及其组分比：
蓖麻子12份，油菜籽13份，大豆10份，鸡肉7份，红糖8份，大蒜18份，柴胡20份，鱼腥草19份，黄芪22份，白术20份。
其制备方法，包括如下步骤：
步骤S1：称取如上所述的质量份的蓖麻子、油菜籽、大豆原料，去除杂质，然后使用粉碎机将原料分别粉碎放入容器中，备用；
步骤S2：称取如上所述的质量份的鸡肉，使用绞肉机绞碎，备用；
步骤S3：将步骤S1粉碎后的原料和步骤S2绞碎后的鸡肉倒入搅拌器中搅拌，在搅拌过程中，加入红糖，搅拌均匀后得预防药剂；
步骤S4：称取如上所述的质量份的大蒜、柴胡、鱼腥草、黄芪、白术，分别粉碎，倒入搅拌器中搅拌均匀，得到治疗药剂；
步骤S5：将步骤S3得到的预防药剂和步骤S4得到的治疗药剂进行搅拌混合，并通过螺杆造粒机造粒，即得到药物。
该药物的使用方法为：与饲料混合投喂，其中药物与饲料的比例为：1：40。
实施例二：
一种用于预防和治疗鳗鲡细菌性肠炎的药物，具体包括以下原料及其组分比：
蓖麻子10份，油菜籽12份，大豆12份，鸡肉8份，红糖12份，大蒜15份，柴胡18份，鱼腥草20份，黄芪23份，白术24份。
其制备方法，包括如下步骤：
步骤S1：称取如上所述的质量份的蓖麻子、油菜籽、大豆原料，去除杂质，然后使用粉碎机将原料分别粉碎，粉碎后的原料放入容器中，备用；
步骤S2：称取如上所述的质量份的鸡肉，使用绞肉机绞碎，备用；
步骤S3：将步骤S1粉碎后的原料和步骤S2绞碎后的鸡肉倒入搅拌器中搅拌，在搅拌过程中，加入红糖，搅拌均匀后得预防药剂；
步骤S4：称取如上所述的质量份的大蒜、柴胡、鱼腥草、黄芪、白术，分别粉碎，倒入搅拌器中搅拌均匀，得到治疗药剂；
步骤S5：将步骤S3得到的预防药剂和步骤S4得到的治疗药剂进行搅拌混合，并通过螺杆造粒机造粒，即得到药物。
该药物的使用方法为：与饲料混合投喂，其中药物与饲料的比例为：1： 30。
实施例三：
一种用于预防和治疗鳗鲡细菌性肠炎的药物，具体包括以下原料及其组分比：
蓖麻子15份，油菜籽14份，大豆9份，鸡肉5份，红糖14份，大蒜18份，柴胡21份，鱼腥草16份，黄芪20份，白术18份。
其制备方法，包括如下步骤：
步骤S1：称取如上所述的质量份的蓖麻子、油菜籽、大豆原料，去除杂质，然后使用粉碎机将原料分别粉碎，粉碎后的原料放入容器中，备用；
步骤S2：称取如上所述的质量份的鸡肉，使用绞肉机绞碎，备用；
步骤S3：将步骤S1粉碎后的原料和步骤S2搅碎后的鸡肉倒入搅拌器中搅拌，在搅拌过程中，加入红糖，搅拌均匀后得预防药剂；
步骤S4：称取如上所述的质量份的大蒜、柴胡、鱼腥草、黄芪、白术，分别粉碎，倒入搅拌器中搅拌均匀，得到治疗药剂；
步骤S5：将步骤S3得到的预防药剂和步骤S4得到的治疗药剂进行搅拌混合，并通过螺杆造粒机造粒，即得到药物。
该药物的使用方法为：与饲料混合投喂，其中药物与饲料的比例为：1： 50。
其中本发明组方中使用到的中药的药理情况为：（1）柴胡：为伞形科植物柴胡或狭叶柴胡的干燥根，性味苦、微寒，归肝、胆经。有通里解表、疏肝升阳之功效。用于发热、寒热往来、疟疾、肝郁气滞等。（2）鱼腥草：为三白草科植物蕺菜的干燥地上部分，味辛，性寒凉，归肺经。能清热解毒、消肿疗疮、利尿除湿、清热止痢、健胃消食，用于治湿热、热毒、湿邪、疾热为患的肺痈、疮疡肿毒、痔疮便血、脾胃积热等。（3）黄芪：为豆科植物蒙古黄芪的根。功能主治为：补气固表，托毒排脓，利尿，生津。用于气虚乏力、疮口久不愈合。（4）白术：为菊科苍术属多年生草本植物，药用功能为运脾药，性味苦温辛烈，有燥湿、化浊、止痛之效。
采用本发明的药物拌饲料喂食鳗鲡，能够有效的增强鳗鲡免疫力。经过试验得到，采用传统疾病防治方法，鳗鲡每月增重7克，且发病率达到7%，而采用本发明的药物拌饲料喂食鳗鲡，每月能增重19克，且发病率降为0.5%。对于已患肠炎的鳗鲡，采用本发明的药物拌饲料喂食，治愈率达到98%。因此，本发明的药物能够有效防治鳗鲡的细菌性肠炎，增强鳗鲡免疫力，有效地促进鳗鲡生长。
以上所述仅为本发明的较佳实施用例而已，并非用于限定本发明的保护范围。凡在本发明的精神和原则之内，所作的任何修改、等同替换以及改进等，均应包含在本发明的保护范围之内。

Claims (4)

  1. 一种用于预防和治疗鳗鲡细菌性肠炎的药物，其特征在于：具体包括以下原料及其组分比：
    蓖麻子10~15份，油菜籽12~14份，大豆9~12份，鸡肉5~8份，红糖12~14份，大蒜15~18份，柴胡18~21份，鱼腥草16~20份，黄芪20~23份，白术18~24份。
  2. 如权利要求1所述的一种用于预防和治疗鳗鲡细菌性肠炎的药物，其特征在于：所述原料及其组分比为：
    蓖麻子12份，油菜籽13份，大豆10份，鸡肉7份，红糖8份，大蒜18份，柴胡20份，鱼腥草19份，黄芪22份，白术20份。
  3. 一种用于预防和治疗鳗鲡细菌性肠炎的药物的制备方法，其特征在于：包括如下步骤：
    步骤S1：称取如权利要求1或2所述的质量份的蓖麻子、油菜籽、大豆原料，去除杂质，然后使用粉碎机将原料分别粉碎，粉碎后的原料放入容器中，备用；
    步骤S2：称取如权利要求1或2所述的质量份的鸡肉，使用绞肉机绞碎，备用；
    步骤S3：将步骤S1粉碎后的原料和步骤S2绞碎后的鸡肉倒入搅拌器中搅拌，在搅拌过程中，加入红糖，搅拌均匀后得预防药剂；
    步骤S4：称取如权利要求1或2所述的质量份的大蒜、柴胡、鱼腥草、黄芪、白术，分别粉碎，倒入搅拌器中搅拌均匀，得到治疗药剂；
    步骤S5：将步骤S3得到的预防药剂和步骤S4得到的治疗药剂进行搅拌混合，并通过螺杆造粒机造粒，即得到药物。
  4. 如权利要求3所述的一种用于预防和治疗鳗鲡细菌性肠炎的药物的制备方法，其特征在于：所述步骤S5得到的药物的使用方法为：与饲料混合投喂，其中药物与饲料的比例为：1：30~50。
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