WO2021010117A1 - Dispositif de mesure d'onde d'impulsion, procédé de mesure et dispositif de mesure de tension artérielle - Google Patents

Dispositif de mesure d'onde d'impulsion, procédé de mesure et dispositif de mesure de tension artérielle Download PDF

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Publication number
WO2021010117A1
WO2021010117A1 PCT/JP2020/024866 JP2020024866W WO2021010117A1 WO 2021010117 A1 WO2021010117 A1 WO 2021010117A1 JP 2020024866 W JP2020024866 W JP 2020024866W WO 2021010117 A1 WO2021010117 A1 WO 2021010117A1
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WIPO (PCT)
Prior art keywords
wave
pulse wave
pulse
blood pressure
unit
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PCT/JP2020/024866
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English (en)
Japanese (ja)
Inventor
啓吾 鎌田
小澤　尚志
彩花 岩出
啓介 齋藤
康大 川端
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オムロン株式会社
オムロンヘルスケア株式会社
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Publication of WO2021010117A1 publication Critical patent/WO2021010117A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
    • A61B5/021—Measuring pressure in heart or blood vessels
    • A61B5/022—Measuring pressure in heart or blood vessels by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers

Definitions

  • An embodiment of the present invention relates to, for example, a pulse wave measuring device and a pulse wave measuring method for measuring a pulse wave using radio waves, and a blood pressure measuring device for estimating blood pressure based on the pulse wave.
  • a device for measuring a pulse wave of a living body using radio waves for example, a device disclosed in Patent Document 1 is known.
  • This device includes a transmitting antenna and a receiving antenna that are arranged so as to face a measured portion such as a blood vessel or a body surface, and transmits radio waves (measurement signals) from the transmitting antenna toward the measured portion (target object).
  • the pulse wave signal is obtained by receiving the reflected wave (reflected signal) of the transmitted radio wave by the measured portion by the receiving antenna.
  • the radio waves transmitted from the antenna have a spread, they are also radiated to biological parts other than the user's measured part and other users and structures located in the surrounding area. Therefore, the receiving antenna receives not only the reflected wave by the part to be measured by the user, but also the radio wave reflected by another biological part or peripheral objects unrelated to the measurement of the pulse wave. As a result, the reflected wave from the user's other biological part or peripheral object becomes noise and affects the reflected wave of the part to be measured, which lowers the measurement accuracy of the pulse wave.
  • the present invention has been made by paying attention to the above circumstances, and an object of the present invention is to provide a technique for improving the measurement accuracy of pulse waves by reducing the influence of reflected waves by a portion unrelated to the portion to be measured. ..
  • the first aspect of the pulse wave measuring device or method according to the present invention is to transmit a transmitted wave composed of radio waves toward a part to be measured of a living body having a transmitting circuit and a transmitting antenna.
  • a receiving unit having a unit, a receiving circuit and a receiving antenna, and receiving a reflected wave of the transmitted wave by the measured portion, and a pulse representing the pulsation of the measured portion based on a signal output from the receiving unit. It is provided with a pulse wave detection unit that detects a wave signal. Then, by the transmission circuit, one of the range of the distance that can be separated and identified by the distance resolution starting from the transmission antenna includes the measured portion and does not include an object located at least far from the measured portion.
  • a short pulse-shaped burst wave having a set pulse width is generated, the burst wave is output to the transmitting antenna as the transmitting wave, and a reference wave generated at the same time as the transmitting wave is output to the receiving circuit.
  • the receiving circuit outputs a signal representing the phase difference between the reflected wave and the reference wave received by the receiving antenna to the pulse wave detection unit.
  • one of the range of the distance that can be separated and identified by the distance resolution starting from the transmitting antenna includes the measured portion and at least one of the measured portions.
  • a short pulse burst wave whose pulse width is set so as not to include a distant object is used. Therefore, for example, even if reflected waves from a noise source such as another user or a structure existing in or around another biological part located far from the measured part are received, these reflected wave components are excluded from the detection target. It is prevented from being mixed into the pulse wave signal. Therefore, it is possible to improve the detection accuracy of the pulse wave signal.
  • the phase of the reflected wave is detected by using the burst wave generated by the transmitting circuit at the same timing as the transmitting wave and transmitted at a fixed distance in the device as the reference wave, so that the part to be measured It is possible to detect the phase change of the reflected wave due to the pulsation of the wave with a relatively simple circuit such as a detection circuit.
  • the transmission circuit uses the radial artery of the user's wrist as the measurement site
  • the range of the distance that can be separated and identified by the distance resolution is the transmission unit.
  • the pulse width is set so as to be within the range not including the body of the user.
  • the reflected wave component by the body portion of the user is excluded from the detection target, and the contamination into the pulse wave signal is prevented. To. Therefore, it is possible to eliminate the influence of the user's body and obtain a high-quality pulse wave signal.
  • the transmission circuit uses the radial artery of the user's wrist as the measurement site
  • the range of the distance that can be separated and identified by the distance resolution is the transmission.
  • the pulse width is set so as to be within a range that does not include an object located around the user from the unit.
  • the measurement site is the radial artery of the wrist of the user
  • another user a structure such as a pillar or a wall, an office device, or the like exists around the user.
  • the reflected wave components due to these are excluded from the detection target, and the mixing into the pulse wave signal is prevented. Therefore, it is possible to obtain a high-quality pulse wave signal by eliminating the influence of other users and objects existing around the user.
  • a fourth aspect of the pulse wave measuring device is to set the pulse width corresponding to a range of distances that can be separated and identified by the distance resolution when the distance resolution is ⁇ d and the light speed is c. ,
  • One aspect of the blood pressure measuring device is provided with at least one set of pulse wave measuring devices, and the at least one set of pulse wave measuring devices is attached to a living body so as to be arranged opposite to an artery as a measurement site. Further, a blood pressure estimation unit connected to the at least one set of pulse wave measuring devices is provided, and the blood pressure estimation unit is used in the measured portion detected by each pulse wave detecting unit of the at least one set of pulse wave measuring devices. The calculation is performed based on a calculation unit that calculates a feature amount of the waveform of the pulse wave signal based on the corresponding pulse wave signal and information representing the relationship between the feature amount and the blood pressure value stored in the memory in advance. It is configured to include an estimation unit that estimates the blood pressure value corresponding to the feature amount and an output unit that outputs the estimated blood pressure value.
  • the measured portion has a range of distances that can be separated and identified by the distance resolution starting from the transmitting antenna as the transmitted wave by at least one set of pulse wave measuring devices.
  • a short pulse burst wave whose pulse width is set so as to include an object located at least far from the measurement site is used. Therefore, for example, even if reflected waves from a noise source such as another user or a structure existing in the vicinity of another biological part located far from the measured part are received, these reflected wave components are excluded from the detection target. It is prevented from being mixed into the pulse wave signal. Therefore, it is possible to obtain a pulse wave signal with higher detection accuracy. Then, by calculating the feature amount of the waveform based on this pulse wave signal and estimating the blood pressure based on this feature amount, it is possible to estimate the blood pressure with high accuracy.
  • two sets of the pulse wave measuring devices are provided, and these two sets of pulse wave measuring devices are used as the first site of the artery as the measured site and the first portion. It is attached to the living body so as to be arranged opposite to the second site on the downstream side of the first site, and each pulse wave detection of the two sets of pulse wave measuring devices is performed by the blood pressure estimation unit as a feature amount of the waveform. Based on the first pulse wave signal corresponding to the first part and the second pulse wave signal corresponding to the second part detected by the part, the first part and the second part The pulse wave velocity may be calculated, and the blood pressure value corresponding to the calculated pulse wave velocity may be estimated. With such a configuration, it is possible to estimate the blood pressure based on the pulse wave velocity (PTT) of the artery.
  • PTT pulse wave velocity
  • each aspect of the present invention it is possible to provide a technique for reducing the influence of the reflected wave by a portion unrelated to the portion to be measured and improving the measurement accuracy of the pulse wave.
  • FIG. 1 is a block diagram showing an application example of one of the pulse wave measuring devices according to the present invention.
  • FIG. 2 is a diagram used for explaining the operation of the application example shown in FIG.
  • FIG. 3 is a perspective view showing the appearance of the blood pressure measuring device according to the embodiment of the present invention.
  • FIG. 4 is a plan view showing the arrangement positions of the antenna substrate and the pressing cuff with respect to the wrist when the blood pressure measuring device shown in FIG. 3 is attached to the left wrist of the user.
  • FIG. 5 is a block diagram showing a circuit configuration of the blood pressure measuring device shown in FIG.
  • FIG. 6 is a waveform diagram for explaining the detection operation of the reflected wave by the artery as the measurement site.
  • FIG. 7 is a waveform diagram for explaining an operation of eliminating noise waves by an object existing far from the measured portion.
  • FIG. 1 is a block diagram showing an application example of one of the pulse wave measuring devices according to the present invention.
  • the pulse wave measuring device includes a transmitting unit 1, a receiving unit 2, and a pulse wave detecting unit 3.
  • the transmitting unit 1 and the receiving unit 2 are arranged to face each other at a position close to the artery 4 as a measurement site.
  • the transmission unit 1 has a transmission circuit and a transmission antenna, generates, for example, a short pulse burst wave TS by the transmission circuit, and transmits the transmission wave E composed of the burst wave as a radio wave from the transmission antenna to the artery 4.
  • the short pulse burst wave TS has a pulse width PW within a range in which the distance resolution starting from the transmitting unit 1 does not include the artery 4 and does not include an object located at least farther from the artery 4. Is set to. At this time, as the object located far away, for example, when the measurement site is the radial artery of the wrist of the user, the torso of the user or another user or structure existing around the user is assumed.
  • the receiving unit 2 has a receiving circuit and a receiving antenna, and receives the reflected wave E'from the surface of the artery 4 of the transmitted wave E transmitted from the transmitting unit 1 by the receiving antenna.
  • the reference wave FS generated from the transmission circuit at the same timing as the burst wave TS as the transmission wave is input to the reception circuit, and the reception circuit detects the reflected wave E'by the reference wave FS.
  • the pulse wave detection unit 3 generates and outputs a pulse wave signal PS representing the pulsation of the artery 4 based on the reception signal RS'output from the reception unit 2.
  • FIG. 2 is a waveform diagram illustrating the operation. That is, in the transmission unit 1, a short pulse burst wave TS is generated by the transmission circuit, and the transmission wave composed of the burst wave TS becomes a radio wave E from the transmission antenna and is transmitted to the artery 4 as the measurement site. The transmitted radio wave E is reflected by the blood vessel surface of the artery 4, and the reflected wave E'is received by the receiving antenna of the receiving unit 2. At this time, the reference wave FS is supplied from the transmission unit 1 to the reception circuit of the reception unit 2. The receiving circuit detects the received waveform signal RS of the reflected wave E'received by the receiving antenna by the reference wave FS.
  • the reference wave FS is, for example, a burst wave generated at the same timing as the burst wave TS as a transmission wave, and has the same frequency component, generation timing, and pulse width RW as the transmission wave.
  • the pulse width RW is such that the range of the distance that can be separated and identified by the distance resolution starting from the transmission unit 1 is within the range that includes the artery 4 and does not include an object located at least farther from the artery 4. It is set.
  • the receiving signal RS'after detection is output from the receiving unit 2, for example, as shown in FIG.
  • the detection signal RS' represents the phase difference between the reflected wave E'and the reference wave FS and the reception intensity of the reflected wave E'.
  • the pulse wave detection unit 3 obtains a signal representing the pulsation of the artery 4 at a certain time point by, for example, converting the phase difference of the detection signal into an amplitude. Be done. That is, by transmitting a transmitted wave at a period sufficiently shorter than the pulsating period of the artery 4, detecting the phase of the reflected wave and converting each into an amplitude, the pulse wave detection unit 3 has a pulse representing the pulsating waveform of the artery 4. It is possible to obtain the wave signal PS.
  • the reflected wave E' is reflected by a body portion such as the user's chest located farther than the artery 4, and also by an object that is a noise source such as another user's body or an indoor structure existing around the user. Waves may be included.
  • the noise source object located farther than the artery 4 is out of the range of the distance that can be separated and identified by the distance resolution of the pulse wave measuring device. Therefore, the reflected wave by the object of the noise source the received waveform signal RS N of (noise wave), even if an attempt is detected by the reference wave FS at the receiving unit 2, not detected.
  • the range of the distance that can be separated and identified by the distance resolution starting from the transmitting unit 1 includes the artery 4 and this artery.
  • a short pulse-shaped burst wave TS in which the pulse width is set so as to be within a range not including an object located at least farther than 4 is used. Therefore, in addition to the reflected wave E'by the artery 4 as the measurement site, even if the reflected wave by the noise source located farther than the artery 4 is received, the received waveform signal RS of the reflected wave by these noise sources N is not detected. Therefore, it is possible to obtain a high-quality pulse wave signal PS by increasing the S / N of the pulse wave signal.
  • FIG. 3 is a perspective view showing the overall structure of the blood pressure measuring device having the function of the pulse wave measuring device according to the embodiment of the present invention.
  • the blood pressure measuring device is of a type used by being worn on the left wrist of the subject, and is worn on the left wrist of the user so as to surround the outer circumference thereof, and the band 20 having a buckle 24 and the band 20. It includes a main body 10 that is integrally attached.
  • a transmission / reception unit 40 constituting the first and second pulse wave sensors is provided at a position on the outer peripheral surface of the band 20 opposite to the main body 10. Further, in the band 20, a pair (transmission / reception antenna group) of the transmission / reception antennas TX1, RX1 and TX2, RX2 is arranged on the inner peripheral surface 20a of the portion where the transmission / reception unit 40 is arranged. The position of the pair of these transmission / reception antennas TX1, RX1 and TX2, RX2 is set so as to face the radial artery passing through the left wrist when the user as the subject passes the left hand through the band 20. Has been done.
  • a display device 50 forming a display screen is provided on the top surface (the surface on the side farthest from the measurement portion) 10a of the main body 10. Further, an operation unit 52 for inputting an instruction from the user is provided at a position along the side surface of the main body 10 (the side surface on the left front side in FIG. 3) on the outer peripheral surface 20b of the band 20.
  • the operation unit 52 includes a push-type switch, and inputs an operation signal in response to a user's instruction to start or stop blood pressure measurement to the processing unit in the main body 10.
  • the operation unit 52 is not limited to the push type switch, and may be, for example, a pressure sensitive type (resistive type) or a proximity type (capacitance type) touch panel type switch. Further, a microphone (not shown) may be provided to input a blood pressure measurement start instruction by a user's voice. Further, the operation unit 52 is not indispensable, and the processing unit described later can be configured to automatically generate a blood pressure measurement start instruction or a stop instruction in response to, for example, an activation signal output from a timer. ..
  • the user who is the subject is measured in the direction indicated by the arrow A in FIG. 3 with the buckle 24 opened in the direction of arrow B and the diameter of the ring of the band 20 is increased. Passes his left hand through band 20. Then, the user adjusts the position of the band 20 in the circumferential direction of the left wrist, and the transmission / reception antennas TX1, RX1 and TX2, RX2 installed on the inner peripheral surface of the band 20 on the radial artery passing through the left wrist. Set so that the pairs of are facing each other.
  • the pair of transmission / reception antennas TX1, RX1 and TX2, RX2 are brought into contact with the portion of the volar surface of the left wrist corresponding to the radial artery.
  • the user closes and fixes the buckle 24.
  • the blood pressure measuring device is worn on the user's left wrist.
  • FIG. 4 is a plan view illustrating each arrangement position of the pair of transmission / reception antennas TX1, RX1 and TX2, RX2 with respect to the radial artery 91 when the main body 10 is attached to the user's left wrist 90.
  • the pair of transmission / reception antennas TX1, RX1 and TX2, RX2 correspond to the position of the radial artery 91 of the left wrist 90 in the longitudinal direction of the left wrist 90 (width of the band 20). They are arranged at a certain distance apart in the direction Y). Further, the transmitting antennas TX1 and TX2 and the receiving antennas RX1 and RX2 are arranged so as to be separated from each other along the circumferential direction of the left wrist 90 (corresponding to the longitudinal direction X of the band 20).
  • the transmitting antennas TX1 and TX2 and the receiving antennas RX1 and RX2 are either vertically or horizontally in terms of plane direction (meaning the direction of the paper in FIG. 4) so that radio waves having frequencies in the GHz band can be transmitted or received. Also has a square pattern shape of about 3 mm.
  • the transmitting antennas TX1 and TX2 and the receiving antennas RX1 and RX2 may be provided with a conductor layer for transmitting radio waves along the surface facing the left wrist 90.
  • the conductor layer faces the palm side surface 90a of the left wrist 90, and the dielectric layer acts as a spacer to keep the distance between the palm side surface 90a of the left wrist 90 and the conductor layer constant. This makes it possible to accurately measure the biological information from the left wrist 90.
  • the conductor layer is made of, for example, a metal (copper or the like), and the dielectric layer is made of, for example, polycarbonate.
  • Such transmitting antennas TX1 and TX2 and receiving antennas RX1 and RX2 are configured to be flat along the plane direction. Therefore, in this blood pressure measuring device, the band 20 can be formed to be thin as a whole.
  • FIGS. 3 and 4 exemplify a blood pressure measuring device provided with two sets of pulse wave sensors
  • the number of sensors is not limited to this.
  • three or more sets of pulse wave sensors may be dispersedly arranged along the radial artery 91, and the pulse waves may be measured at three or more positions of the radial artery by these pulse wave sensors.
  • the number of measured pulse wave signals can be increased, so that the accuracy when calculating the pulse wave velocity (PTT), for example, can be improved.
  • the pulse wave sensor is not limited to a plurality of sets and may be one set.
  • FIG. 5 is a block illustrating the circuit configuration of the blood pressure measuring device.
  • the blood pressure measuring device includes a plurality of sensor units and a processing unit 12.
  • the sensor units are shown as the first sensor unit 130-1 and the second to nth sensor units 130-2 to 130-n.
  • the first sensor unit 130-1 and the second sensor unit 130-2 will be described, and the description of the other sensor units will be omitted.
  • the first sensor unit 130-1 and the second sensor unit 130-2 have a pair of a transmitting antenna TX1 and a pair of a receiving antenna RX1 and a pair of a transmitting antenna TX2 and a receiving antenna RX2, respectively.
  • the transmitting antennas TX1 and TX2 and the receiving antennas RX1 and RX2 are both directional in the direction of the measurement site including the radial artery 91.
  • first sensor unit 130-1 and the second sensor unit 130-2 include a pair of the transmission circuit TC1 and the reception circuit RC1 and a pair of the transmission circuit TC2 and the reception circuit RC2, respectively.
  • the transmitting circuit TC1 and the receiving circuit RC1 are connected to the transmitting antenna TX1 and the receiving antenna RX1, respectively, and the transmitting circuit TC2 and the receiving circuit RC2 are connected to the transmitting antenna TX2 and the receiving antenna RX2, respectively.
  • the transmission circuits TC1 and TC2 generate a transmission wave at a fixed cycle and supply it to the transmission antennas TX1 and TX2, whereby the transmission antennas TX1 and TX2 transmit radio waves by the transmission wave to the measured portion.
  • radio waves (transmitted waves) E1 and E2 are transmitted toward the left wrist 90 (more accurately, the corresponding portion of the radial artery 91) as the measurement site.
  • the transmission circuits TC1 and TC2 generate a reference wave at the same timing as the transmission wave, and supply the reference wave to the pair of reception circuits RC1 and RC2. The transmitted wave and the reference wave will be described in detail below.
  • the transmitted wave is composed of a short pulse burst wave.
  • the pulse width PW of this burst wave has a range of distances that can be separated and identified by the distance resolution starting from the transmitting antennas TX1 and TX2, including the radial artery 91 as the measurement site, and is located far from the radial artery 91. It is set so that it does not include the object to be used.
  • the pulse width is set to 2 nsec.
  • the separation target is assumed to be a peripheral object having a distance of 75 cm or more from the transmitting antennas TX1 and TX2 (for example, a structure such as another user's body, a pillar, a wall, or office equipment existing in the vicinity)
  • a pulse is generated.
  • the width is set to 5 nsec.
  • the pulse width PW is set to a value according to the distance resolution of the setting target within a range of, for example, 5 nsec as the upper limit and 1 nsec as the lower limit.
  • the frequency bandwidth ⁇ f is set to 0.5 GHz.
  • the frequency bandwidth ⁇ f is set to 0.2 GHz.
  • 7.25 to 10.25 GHz is selected as an example in order to maintain the pulse wave detection performance of a predetermined value or higher.
  • the receiving circuits RC1 and RC2 receive the reflected waves E1'and E2' by the radial artery 91 of the radio waves E1 and E2, respectively, via the receiving antennas RX1 and RX2. Further, the receiving circuits RC1 and RC2 introduce burst waves generated in the transmitting circuits TC1 and TC2 as reference waves FS1 and FS2, respectively.
  • the burst waves serving as the reference waves FS1 and FS2 have the same frequency and the same pulse width as the burst waves generated as the transmission waves, and are generated at the same timing.
  • the receiving circuits RC1 and RC2 detect the received waveform signals RS1 and RS2 of the reflected waves E1'and E2'by the reference waves FS1 and FS2, thereby causing the reflected waves E1'and E2'and the reference waves FS1 and FS2.
  • the received signals RS1'and RS2'indicating the phase difference between the two and the reception intensity of the reflected waves E1'and E2' are output.
  • the received signals RS1'and RS2' after the detection are amplified to, for example, the signal level required for A / D conversion, converted into a digital signal by an A / D converter, and output to the processing unit 12.
  • the processing unit 12 includes, for example, a hardware processor such as a central processing unit (CPU) and a storage unit, and as a processing function unit according to one embodiment, pulse wave detection units 101-1 and 101-2, ..., 101-n (101-1 to 101-n), a PTT calculation unit 103, a blood pressure estimation unit 104, and an output unit 105. All of these processing function units are realized by causing the hardware processor to execute a program stored in a storage unit (not shown).
  • a hardware processor such as a central processing unit (CPU) and a storage unit
  • a processing function unit according to one embodiment, pulse wave detection units 101-1 and 101-2, ..., 101-n (101-1 to 101-n), a PTT calculation unit 103, a blood pressure estimation unit 104, and an output unit 105. All of these processing function units are realized by causing the hardware processor to execute a program stored in a storage unit (not shown).
  • the storage unit is configured by combining HDD (Hard Disk Drive), SSD (Solid State Drive), ROM, RAM, etc. as a storage medium, and controls a program for controlling the blood pressure measuring device and the blood pressure measuring device. Control data used for this purpose, setting data for setting various functions of the blood pressure measuring device, detection signals of pressure and pulse waves, data representing blood pressure measurement results, etc. are stored.
  • the storage unit is also used as a work memory or the like when a program is executed.
  • the pulse wave detection units 101-1 and 101-2 take in the digitized reception signals RS1'and RS2' from the reception circuits RC1 and RC2, respectively. Then, the pulse wave signals PS1 and PS2 representing the pulsating waveform of the radial artery 91 are detected based on the received signals RS1'and RS2' that are taken in at regular time intervals. Then, the pulse wave signals PS1 and PS2 are output to the PTT calculation unit 103.
  • the pulse wave detection units 101-1 and 101-2 may be realized by an analog circuit provided independently, in addition to being realized by software processing by the CPU.
  • the PTT calculation unit 103 calculates the time difference between the pulse wave signals PS1 and PS2 output from the pulse wave detection units 101-1 and 101-2 as the pulse wave velocity (PTT), and calculates the pulse wave velocity.
  • the time (PTT) is output to the blood pressure estimation unit 104.
  • the blood pressure estimation unit 104 is based on, for example, the pulse wave velocity (PTT) calculated by the PTT calculation unit 103 and a correspondence formula stored in a storage unit (not shown) that expresses the relationship between the PTT and the blood pressure value.
  • the blood pressure value corresponding to the calculated pulse wave velocity (PTT) is estimated. Then, the estimated value of blood pressure is output to the output unit 105.
  • the output unit 105 displays the estimated value of blood pressure output from the blood pressure estimation unit 104 on the display 50 shown in FIG.
  • the display 50 for example, an organic EL (Electro Luminescence) display is used.
  • the display 50 is not limited to the organic EL display, and may be another type of display such as a liquid crystal display (Liquid Crystal Display: LCD) or a display using 7 segments.
  • LCD Liquid Crystal Display
  • the output unit 105 may have, for example, a function of storing the estimated blood pressure value in a storage unit (not shown) or outputting it to an external device via a network.
  • the estimated value of blood pressure may include information indicating the measurement date and time and other additional information such as the name of the user to be measured or the ID of the pulse wave measuring device, and further, the pulse wave detecting unit 101.
  • this pulse rate may be included in the additional information.
  • the CPU of the processing unit 12 instructs the transmission circuits TC1 and TC2 to start transmitting the transmission wave.
  • the transmission circuits TC1 and TC2 Upon receiving the above instruction, the transmission circuits TC1 and TC2 generate short pulse burst waves at preset time intervals, and the generated burst waves are supplied to the transmission antennas TX1 and TX2 as transmission waves.
  • the pulse width PW of each burst wave includes the radial artery 91, which is the measurement site, in the range of the distance that can be separated and identified by the distance resolution starting from the transmitting antennas TX1 and TX2, and is from the radial artery 91. It is set so that it does not include objects located in the distance. For example, as described above, the value is set according to the desired distance resolution within the range of, for example, 5 nsec as the upper limit and 1 nsec as the lower limit.
  • radio waves E1 and E2 generated by the above-mentioned transmitted waves are transmitted from the transmitting antennas TX1 and TX2 to different parts of the radial artery 91 in the blood flow direction.
  • the transmitted wave may be generated from the transmission circuits TC1 and TC2 at regular time intervals, may be generated at irregular time intervals, and may be continuously generated. You may do so.
  • the reflected waves E1'and E2'by the radial artery 91 of the radio waves E1 and E2 are received by the receiving antennas RX1 and RX2 as shown in FIG. 4, and the received waveform signals RS1 and RS2 are received by the receiving circuits RC1 and RC1. It is input to RC2.
  • the received waveform signals RS1 and RS2 of the reflected waves E1'and E2' are detected by the reference waves FS1 and FS2 output from the transmitting circuits TC1 and TC2, respectively.
  • the detection provides a signal indicating the phase difference between the reflected waves E1'and E2'and the reference waves FS1 and FS2 and the reception intensity of the reflected waves E1'and E2'.
  • the radio waves E1 and E2 as the transmitted waves include the radial artery 91 whose measurement site is the range of the distance that can be separated and identified by the distance resolution starting from the transmitting antennas TX1 and TX2, and from the radial artery 91. It consists of a short pulse-shaped burst wave in which the pulse width PW is set so as to be within a range that does not include an object located at a distance. Therefore, the received waveform signals RS S of the reflected waves E1'and E2' by the radial artery 91 as the measurement site are detected by the reference waves FS1 and FS2 as shown in FIG.
  • the reception timing of the reflected wave by the user's body or surrounding objects located far from the radial artery 91 is the pulse of the burst wave constituting the radio waves E1 and E2 as the transmitted wave and the reference waves FS1 and FS2. It is out of the range of the distance that can be separated and identified by the distance resolution defined by the width PW. Therefore, for example, as shown in FIG. 7, the received waveform signal RS N of the reflected wave is not detected by the reference waves FS1 and FS2, and as a result, the received signals RS1'and RS2' are not output.
  • the received signals RS1'and RS2' obtained by the above detection are further amplified to the signal level required for A / D conversion in the receiving circuits RC1 and RC2, converted into digital signals by the A / D converter, and processed. It is input to the unit 12.
  • the processing unit 12 captures the detected reception signals RS1'and RS2' output from the reception circuits RC1 and RC2, respectively, in the pulse wave detection units 101-1 and 101-2, respectively, and the pulse wave signals are as follows. Detects PS1 and PS2.
  • the pulse wave detection unit 101-1 detects the pulse wave signal PS1 representing the pulse wave of the upstream portion of the radial artery 91 from the output of the receiving circuit RC1 in the diastole period and the output in the blood vessel systole period. Further, the pulse wave detection unit 101-2 detects the pulse wave signal PS2 representing the pulse wave in the downstream portion of the radial artery 91 from the output of the receiving circuit RC2 in the diastole period and the output in the blood vessel systole period.
  • the pair of transmission / reception antennas TX1 and RX1 is in the longitudinal direction of the left wrist 90 (corresponding to the width direction Y of the band 20). It faces the upstream site of the radial artery 91 passing through the left wrist 90.
  • the pair of transmission / reception antennas TX2 and RX2 faces the downstream portion of the radial artery 91.
  • the signal detected by the pair of transmitting and receiving antennas TX1 and RX1 is the change in the distance between the blood vessel surface at the upstream part of the radial artery 91 and the pair of the transmitting and receiving antennas TX1 and RX1, that is, the pulsation at the upstream part of the radial artery 91. Represents (dilation and contraction of blood vessels).
  • the signal detected by the pair of transmitting and receiving antennas TX2 and RX2 is the change in the distance between the blood vessel surface and the pair of transmitting and receiving antennas TX2 and RX2 at the downstream site of the radial artery 91, that is, the downstream side of the radial artery 91.
  • the pulse wave detection unit 101-1 corresponding to the first sensor unit 130-1 and the pulse wave detection unit 101-2 corresponding to the second sensor unit 130-2 are based on the output signals of the receiving circuits RC1 and RC2, respectively. Therefore, the first pulse wave signal PS1 and the second pulse wave signal PS2 having a mountain-shaped waveform as shown in FIG. 4 are output in chronological order.
  • the reception level of the reception antennas RX1 and RX2 is about 1 ⁇ W (-30 dBm in decibel value for 1 mW).
  • the output level of the receiving circuits RC1 and RC2 is about 1 volt.
  • the peaks A1 and A2 of the first pulse wave signal PS1 and the second pulse wave signal PS2 are about 100 mV to 1 volt, respectively.
  • the processing unit 12 then operates as a PTT calculation unit 103 by executing an application program, and the pulse wave signal PS1 detected at the upstream site of the radial artery 91 and the pulse wave signal PS1 detected at the downstream site of the radial artery 91 are detected.
  • the time difference between the pulse wave signal PS2 and the pulse wave signal PS2 is calculated as the pulse wave velocity (PTT).
  • the time difference ⁇ t between the peak A1 of the first pulse wave signal PS1 and the peak A2 of the second pulse wave signal PS2 shown in FIG. 4 is calculated as the pulse wave propagation time (PTT).
  • the pulse wave propagation time (PTT) is not limited to the time difference ⁇ t between the peaks of the first and second pulse wave signals PS1 and PS2, for example, the waveforms of the first and second pulse wave signals PS1 and PS2. It may be calculated as a time difference between the rise timings.
  • the processing unit 12 subsequently operates as the blood pressure estimation unit 104 by executing the application program, and reads out the relational expression (also referred to as the corresponding expression) Eq between the pulse wave velocity (PTT) and the blood pressure from the storage unit. Then, the estimated value of blood pressure is calculated based on the corresponding formula Eq and the pulse wave velocity (PTT) calculated by the PTT calculation unit 103.
  • the processing unit 12 compares the estimated blood pressure value with a preset threshold value representing a normal range of blood pressure, and is indicated by this threshold value. Determine if it is out of range. Then, if the estimated value of the blood pressure is within the range indicated by the threshold value, the measurement control is repeated until the operation unit 52 inputs an instruction to end the blood pressure measurement based on the pulse wave velocity (PTT).
  • the processing unit 12 outputs the estimated blood pressure value calculated by the blood pressure estimation unit 104 to the display 50 together with the additional information by the output unit 105 and displays it.
  • a transmission wave composed of a short pulse burst wave is generated in the transmission circuits TC1 and TC2, and this transmission wave is supplied to the transmission antennas TX1 and TX2.
  • the radio waves E1 and E2 are transmitted to the sites having different blood flow directions of the radial artery 91 as the measurement site.
  • the pulse width PW of the burst wave includes the radial artery 91, which is the measurement site, in the range of the distance that can be separated and identified by the distance resolution starting from the transmitting antennas TX1 and TX2, and is from the radial artery 91.
  • the reflected waves E1'and E2'by the radial artery 91 of the radio waves E1 and E2 are detected by the reference waves FS1 and FS2 in the receiving circuits RC1 and RC2, respectively.
  • the reference waves FS1 and FS2 burst waves generated in the transmission circuits TC1 and TC2 having the same frequency and pulse width as the burst wave as the transmission wave and at the same timing are used.
  • the received signals RS1'and RS2' after the detection are input to the pulse wave detection units 101-1 and 101-2 to detect the pulse wave representing the pulsation of the radial artery 91.
  • the reflected waves E1'and E2' by the radial artery 91 located within the range of the distance that can be separated and identified by the distance resolution are detected by the reference waves FS1 and FS2, and the received signal after the detection. Is used to generate a pulse wave signal by the pulse wave detection units 101-1 and 101-2.
  • the noise sources such as the user's body and surrounding objects located far from the radial artery 91 are outside the range of the distance that can be separated and identified by the distance resolution, the received waveform signal of the reflected wave by the noise source.
  • RS N is not detected by the reference waves FS1 and FS2.
  • the received waveform signal RS N of the reflected waves by the noise source is input as a noise in the pulse wave detection section 101-1 and 101-2 is prevented. Therefore, it is possible to reduce the influence of the reflected wave due to the noise source such as the user's body and surrounding objects, and further improve the quality of the pulse wave signal.
  • the pulse wave velocity (PTT) is calculated by the PTT calculation unit 103 based on the high-quality pulse wave signal in which the influence of the reflected wave by the noise source as described above is reduced, and the blood pressure value is calculated by the blood pressure estimation unit 104. By estimating, it is possible to further improve the accuracy of blood pressure measurement by the PTT method.
  • the measurement accuracy of the blood pressure value estimated by the PTT method can be estimated by the difference from the blood pressure value measured by this oscillometric method, for example, by using the blood pressure measurement by the oscillometric method together.
  • variable control of the pulse width PW for example, a learning model is used, and an estimated value of blood pressure measurement accuracy by the PTT method or a detection accuracy of a pulse wave signal estimated from this estimated value is input to this learning model for learning. This can be realized by outputting the correction value of the pulse width or the data representing the corrected pulse width from the model.
  • the variable control of the pulse width can be realized by controlling the operation of the burst wave generation circuit with the switching function by the CPU. By providing the variable pulse width control function in this way, it is possible to set the optimum pulse width PW according to the measurement environment of the user.
  • the pair of transmission / reception antennas TX1, RX1 and TX2, RX2 are arranged so as to correspond to the width direction Y of the band 20, that is, the longitudinal direction of the radial artery 91, thereby estimating the blood pressure by PTT.
  • the present invention is not limited to this configuration, and only one transmission / reception antenna pair may be provided so as to detect the pulse wave at any one position of the radial artery 91.
  • the blood pressure measuring device calculates the feature amount of the waveform of the pulse wave signal detected by the pair of transmission / reception antennas, and uses a formula or a memory table showing the relationship between the feature amount and the blood pressure value to perform the above calculation.
  • the blood pressure is estimated by obtaining the blood pressure value corresponding to the feature amount.
  • the pair of transmission / reception antennas TX1, RX1 and TX2, RX2 are arranged along the longitudinal direction (Y direction) of the radial artery 91 at a predetermined interval.
  • the present invention is not limited to this, and the pair of the transmission / reception antennas TX1, RX1 and TX2, RX2 are arranged at predetermined intervals in the direction orthogonal to the radial artery 91, that is, in the circumferential direction (X direction) of the band 20. You may.
  • the set of the antenna boards may be one set, but a plurality of sets may be arranged at predetermined intervals in the X direction.
  • the measurement signal and the reflected signal are transmitted and received at a plurality of positions in the direction orthogonal to the radial artery 91, respectively. Therefore, for example, even if there are individual differences in the position of the user's radial artery 91, or even if the mounting position of the band 20 with respect to the measurement site deviates in the X direction, at least one of the plurality of antenna substrates can be used. It is possible to bring it closer to the artery, which makes it possible to measure the pulse wave with good quality.
  • the blood pressure measuring device is provided with the function of the pulse wave measuring device, the pulse wave signal is detected, and the blood pressure value is measured by the PTT method based on the pulse wave signal has been described as an example.
  • the blood pressure value may be estimated by a method other than the PTT method, or a device having only a pulse wave measurement function may be configured to measure only the pulse rate or analyze the pulse wave waveform. Other information may be obtained from the pulse wave, such as determining the cardiovascular condition of the user or authenticating the user's identity.
  • the blood pressure measuring device is worn only at the time of measurement on other upper limbs such as the upper arm and lower limbs such as the thigh and ankle. May be good. At that time, the mounting position may be any position as long as the artery exists under the skin.
  • the present invention is not limited to the above embodiment as it is, and at the implementation stage, the components can be modified and embodied within a range that does not deviate from the gist thereof.
  • various inventions can be formed by an appropriate combination of a plurality of components disclosed in the above-described embodiment. For example, some components may be removed from all the components shown in the embodiments. In addition, components from different embodiments may be combined as appropriate.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physiology (AREA)
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  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

L'objectif de la présente invention est d'améliorer la précision de mesure d'ondes d'impulsion par réduction de l'influence d'ondes réfléchies par des sites étrangers sur le site de mesure.　Selon un aspect de la présente invention, afin de mesurer des ondes d'impulsion, une unité de transmission (1) génère une onde de transmission comprenant une onde de salve à impulsions brèves et transmet l'onde à une artère (4) à mesurer. Selon ce procédé, la largeur d'impulsion de l'onde de salve est réglée de sorte que la plage d'une distance de séparation discernable par résolution de distance, tandis que l'unité de transmission (1) constitue le point d'origine, comprenne l'artère (4) à mesurer mais aucun objet positionné plus loin que l'artère (4). Selon cet aspect de la présente invention, une unité de réception (2) reçoit une onde réfléchie de l'onde de transmission depuis l'artère (4), le signal de forme d'onde reçu est détecté à l'aide de l'onde de salve sous forme de signal de référence, le signal reçu après la détection est appliqué à une unité de détection d'onde d'impulsion (3) et un signal d'onde d'impulsion (PS), indiquant la pulsation de l'artère (4), est détecté.
PCT/JP2020/024866 2019-07-17 2020-06-24 Dispositif de mesure d'onde d'impulsion, procédé de mesure et dispositif de mesure de tension artérielle WO2021010117A1 (fr)

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JP2019-132164 2019-07-17
JP2019132164A JP2021016431A (ja) 2019-07-17 2019-07-17 脈波測定装置および測定方法、血圧測定装置

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005102959A (ja) * 2003-09-30 2005-04-21 Seiko Epson Corp 脈波検出器及びこれを使用した脈波検出装置
JP2015077395A (ja) * 2013-10-17 2015-04-23 財團法人工業技術研究院Ｉｎｄｕｓｔｒｉａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ 生理測定のための検出システムと方法
WO2019053999A1 (fr) * 2017-09-12 2019-03-21 オムロン株式会社 Dispositif de mesure d'onde d'impulsion, dispositif de mesure de pression artérielle, équipement, procédé de mesure d'onde d'impulsion, et procédé de mesure de pression sanguine

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005102959A (ja) * 2003-09-30 2005-04-21 Seiko Epson Corp 脈波検出器及びこれを使用した脈波検出装置
JP2015077395A (ja) * 2013-10-17 2015-04-23 財團法人工業技術研究院Ｉｎｄｕｓｔｒｉａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｒｅｓｅａｒｃｈ Ｉｎｓｔｉｔｕｔｅ 生理測定のための検出システムと方法
WO2019053999A1 (fr) * 2017-09-12 2019-03-21 オムロン株式会社 Dispositif de mesure d'onde d'impulsion, dispositif de mesure de pression artérielle, équipement, procédé de mesure d'onde d'impulsion, et procédé de mesure de pression sanguine

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