WO2021004367A1 - Appareil de génération de champ électrique et son utilisation, et procédé d'anesthésie d'un corps vivant grâce à celui-ci - Google Patents

Appareil de génération de champ électrique et son utilisation, et procédé d'anesthésie d'un corps vivant grâce à celui-ci Download PDF

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Publication number
WO2021004367A1
WO2021004367A1 PCT/CN2020/099898 CN2020099898W WO2021004367A1 WO 2021004367 A1 WO2021004367 A1 WO 2021004367A1 CN 2020099898 W CN2020099898 W CN 2020099898W WO 2021004367 A1 WO2021004367 A1 WO 2021004367A1
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WO
WIPO (PCT)
Prior art keywords
electric field
anesthesia
generating device
field generating
living body
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Application number
PCT/CN2020/099898
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English (en)
Chinese (zh)
Inventor
乐飚
唐万福
奚勇
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上海必修福企业管理有限公司
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Priority to CN202090000741.9U priority Critical patent/CN218739871U/zh
Publication of WO2021004367A1 publication Critical patent/WO2021004367A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Definitions

  • the invention relates to an electric field generating device capable of anesthetizing a living body, its use and a method for applying the same to anesthetizing a living body.
  • the original intention of anesthesia is to use drugs or other methods to make the person's whole body or part of the body temporarily lose consciousness in order to achieve the goal of painlessness.
  • Anesthesia can generally be divided into local anesthesia and general anesthesia.
  • General anesthetics are mainly inhaled through the respiratory tract or injected into the human body, and quickly spread to the brain through blood circulation, causing central nerve paralysis. At this time, the patient loses consciousness and achieves the effect of general anesthesia.
  • the main risk of this approach is to inhibit brain function, which may affect the respiratory system and circulatory system, causing hypoxia, and in severe cases, the heart stops.
  • Local anesthesia is the application of local anesthetics to a certain part of the patient that needs surgery to block the conduction of local nerves in that part. During the operation, the painful stimulus will no longer be transmitted to the brain, achieving the effect of suppressing surgical pain. This method of anesthesia works locally, but due to its high toxicity, it may also cause breathing and heartbeat to stop.
  • the invention provides an electric field generating device capable of anesthetizing a living body, its use, and a method for applying the same to anesthetize the living body.
  • An object of the present invention is to provide an electric field generating device for anesthetizing a living body, which is characterized by comprising: two poles for forming an electric field, wherein the electric field covers a part of the living body to be anesthetized to achieve anesthesia.
  • one of the two poles is a contact electrode which is in contact with the living body, and the other electrode covers the anesthesia electrode near the part to be anesthetized of the living body, and only the contact electrode is in contact with the living body.
  • the arrangement of the multiple anesthesia electrodes is selected from a lattice arrangement, which is a 2 m lattice, where m is a non-zero natural number.
  • each anesthesia electrode is coated with an insulating material or is made of insulating material to prevent mutual interference between adjacent anesthesia electrodes.
  • the working voltage range of the electric field is 1-1000V, and the working distance of the electric field is 0.1-100 cm.
  • the working distance is any one of 0.1 cm and 10 cm.
  • the electric field generating device further includes a power supply.
  • the electric field generating device further includes a regulating unit for regulating the electric field intensity of the electric field.
  • the present invention also provides a use of an electric field generating device to allow a substance to be penetrated into a target object, wherein the electric field generating device is the above-mentioned electric field generating device.
  • the present invention also provides a method for anesthetizing a living body, using an electric field generated by an electric field generating device to anesthetize the living body, wherein the electric field generating device is the above-mentioned electric field generating device.
  • the method includes the following steps: step 1, contacting the contact electrode in the electric field generating device with the living body; step 2, allowing the electric field generated by the contact electrode and the anesthetic electrode in the electric field generating device to cover the living body The area to be anesthetized to achieve anesthesia.
  • the arrangement of the multiple anesthesia electrodes is selected from a lattice arrangement, which is a 2 m lattice, where m is a non-zero natural number.
  • the bottom of each anesthesia electrode is coated with an insulating material or is made of insulating material to prevent mutual interference between adjacent anesthesia electrodes.
  • the working voltage range of the electric field is 1-1000V, and the working distance of the electric field is 0.1-100cm.
  • the working distance is any one of 0.1 cm and 10 cm.
  • the electric field generating device further includes a power supply.
  • the electric field generating device further includes a regulating unit for regulating the electric field intensity of the electric field.
  • the electric field generating device provided by the present invention, its use, and the method for making the substance to be transdermal enter the target object have been verified by experiments.
  • the electric field can realize the anesthesia of the living body. By covering the electric field to the part of the living body to be anesthetized, it breaks through the stratum corneum and The capillaries regulate and shield the transmission of painful nerve signals at the target site (the site to be anesthetized) to achieve the function of non-invasive local anesthesia.
  • the electric field device since one of the two poles is a contact electrode and the other is an anesthesia electrode to form an electric field, and because only the contact electrode is in contact with the living body, the contact electrode is in contact with the living body to form an equipotential, compared to other forms
  • the electric field both poles that generate the electric field are in contact with the living body or neither touch the living body, it is easier to locate the anesthesia site, and it is safer and more reliable.
  • Fig. 1 is a structural diagram of an electric field generating device related to embodiment 1;
  • FIG. 2 is a schematic diagram of the arrangement of anesthesia electrodes of the electric field generating device related to Embodiment 1.
  • FIG. 2 is a schematic diagram of the arrangement of anesthesia electrodes of the electric field generating device related to Embodiment 1.
  • the following embodiments are intended to specifically illustrate the electric field generating device and its use according to the present invention and the method of applying it to anesthetize a living body.
  • Fig. 1 is a configuration diagram of an electric field generating device according to an embodiment.
  • the electric field generating device 100 is used to anesthetize a living body, especially for local anesthesia of the living body 1.
  • the electric field generating device 100 includes two poles 10 and 20 for forming an electric field. That is, one of them serves as a cathode and one serves as an anode, and the electric field generated by the two poles covers the area to be anesthetized to achieve anesthesia.
  • one of the two poles is the contact electrode 10 that is in contact with the living body, and the other electrode covers the anesthesia electrode 20 near the part to be anesthetized in the living body. Among them, only the contact electrode 10 is in contact with the living body to form an equipotential.
  • the contact electrode 10 and the anesthesia electrode 20 are determined to be positive or negative, and the corresponding other is negative or positive.
  • the contact electrode 10 can also be grounded, which is safer than other forms of electric fields.
  • the working voltage range of the electric field is 1-1000V, and the working distance of the electric field is 0.1-100cm. Therefore, the electric field intensity received by the living body will not be too large to cause damage to the living body, nor will the electric field intensity received by the living body be too small to achieve the purpose of anesthesia.
  • the voltage of the electric field is preferably 1V, 3V, 10V, 30V, 100V, 300V And one of 1000V; working distance is either 0.1cm or 10cm.
  • the working distance here refers to the distance from the anesthesia electrode 20 to the part to be anesthetized.
  • anesthesia electrodes 20 which facilitates the positioning of the electric field to the part to be anesthetized.
  • FIG. 2 is a schematic diagram of the first pole arrangement of the spatial electric field generating device according to the embodiment.
  • the arrangement of the multiple anesthesia electrodes 20 is selected from a lattice arrangement, which is a 2 m lattice, where m is a non-zero natural number, specifically 64 lattices, 4096 lattices, 16777216 lattices, etc. as shown in picture 2.
  • the density of the lattice depends on the accuracy of the electric field. Using precise electric field to improve the efficiency of the basal layer of the skin and reduce the effect on normal tissues. However, limited by the size of the output electric field power supply, the lattice is dense and the power supply is bulky.
  • any one or more meridians from a ⁇ b ⁇ c to xx, and any one or more wefts from 1 ⁇ 2 ⁇ 3 to nn activate one or more lattice anesthesia electrodes 20, where activation means finger connection Power on.
  • the activated anesthesia electrode 20 and the contact electrode 10 constitute an applied electric field, and the electric field coverage is determined by the activated lattice electrode.
  • This range can come from the digital signal of medical diagnostic imaging. It is confirmed that this electric field range can accurately act on nerve cells and reduce the impact on other tissues.
  • a 64 dot matrix can only distinguish 64 electric field positions
  • a 4096 dot matrix can distinguish 4096 electric field positions
  • a 16777216 dot matrix can distinguish 16,777216 electric field positions.
  • Figure 1 illustrates the positions of several anesthesia electrodes 20 positioned to the site to be anesthetized, namely: nx, c3 and a1.
  • the electric field generating device 100 further includes: a power supply 30 and a control unit.
  • the power supply 30 is used to provide electric energy to the electric field generating device 100, the voltage is adjustable 1V-1000V, and the current output is adjustable 0.001mA-1mA.
  • the control unit is used to adjust and control the performance of the electric field.
  • the parameters related to the electric field performance mainly include one or more of electric field type, electric field direction, electric field strength, voltage, current, voltage waveform, frequency, and power frequency, waveform, and amplitude. Essentially, the performance of the electric field is confirmed by the area to be anesthetized and the electric field strength.
  • the regulating unit can regulate the generation of the first signal and the second signal.
  • the first signal is used to generate the electric field direction signal for local anesthesia, and the relative direction of the electric field is controlled to be the direction of the site to be anesthetized; the second signal is used to generate the electric field to promote the formation of the electric field.
  • the first signal controls the electrode polarity to be opposite, and the second signal adjusts the anesthesia electrode 20 to generate an electric field strength of 1V/cm to 1000V/cm.
  • the electric field generating device 100 can be applied to anesthetize a living body.
  • the bottom of the anesthesia electrode 20 may also be coated with insulating material or made of insulating material to prevent mutual interference between adjacent anesthesia electrodes 20.
  • this embodiment also provides a method for anesthetizing a living body, which is characterized in that it includes the following steps:
  • Step 1 Contact the contact electrode 10 in the electric field generating device 100 with a living body;
  • Step 2 Let the electric field generated by the contact electrode 10 and the anesthesia electrode in the electric field generating device 100 cover the part to be anesthetized in the living body to achieve anesthesia.
  • A. Shallow anesthesia The time from the start of electric field anesthesia or the injection of the positive control drug until it naturally falls to the ground and lies on the ground is more than 10 minutes. The animal’s breathing, heart rate, and body temperature decreased slightly, needles pierced the animal’s head, neck, trunk, and the upper limbs of the animal’s pain loss, and the eyelid reflexes were sensitive.
  • Moderate anesthesia The time from the start of electric field anesthesia or the time when the positive control injects the drugs naturally falls to the ground and lies on the ground within 5-10 minutes.
  • Animal breathing rate is 10-20 times/min, heart rate is more than 50 times, body temperature is lowered by 1-2°, acupuncture animal head, neck, trunk, upper limbs and upper limbs disappeared, and eyelid reflex disappeared.
  • Deep anesthesia The time from the start of electric field anesthesia or the time when the positive control injects the drug to naturally fall to the ground and lie down below 4 minutes.
  • Animal breathing rate is below 10 times/min, heart rate is above 40 times, body temperature is lowered to 36° or below, acupuncture the animal's head, neck, trunk, upper extremities, pain disappears, eyelid reflex disappears, eyeball reverses downward, only part of the cornea is seen .
  • Balbc mouse weight 20g, healthy, and shiny fur was used as a candidate, and the local anesthesia comparison verification test was implemented after 1 week of adaptation to the environment.
  • mice meeting the standard into different electric field local anesthesia groups (according to the electric field voltage generated: group A (1V); group B (3V); group C (10V); group D (30V) ; E group (100V); F group (300V) and G group (1000V), 5 in each group.
  • group A (1V); group B (3V); group C (10V); group D (30V) ; E group (100V); F group (300V) and G group (1000V) 5 in each group.
  • each mouse was continuously stimulated for 10 minutes. After the test, the natural fall was recorded The time until the abdomen is lying, the anesthesia effect is judged by the animal's breathing, heart rate, body temperature, and eyelid reflex sensitivity.
  • mice in the electric field anesthesia experiment group were also subjected to the same electric field local anesthesia experiment for 10 minutes. Record the time until the mice naturally fall to the ground and lie on their abdomen in the experiment. According to the standard of anesthesia in the small animal test, the anesthesia effect is judged by the animal's respiration, heart rate, body temperature, eyelid reflex sensitivity, etc. The experimental results are shown in Table 1.
  • the purpose of avoiding excessive anesthesia is that the voltage should be gradually increased through preliminary experiments according to the tolerance of the test subjects to maintain the best anesthesia effect.
  • both poles forming the electric field of the electric field generator is in contact with the living body (contact electrode).
  • both poles forming the electric field may be in contact with the living body or neither of them.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Electrotherapy Devices (AREA)

Abstract

Appareil de génération de champ électrique (100) capable d'anesthésier un corps vivant (1) et son utilisation, et un procédé d'anesthésie d'un corps vivant (1) grâce à celui-ci. L'appareil de génération de champ électrique (100) comprend : deux électrodes (10, 20) pour former un champ électrique, le champ électrique recouvrant une partie, devant être anesthésiée, d'un corps vivant (1) pour réaliser une anesthésie.
PCT/CN2020/099898 2019-07-10 2020-07-02 Appareil de génération de champ électrique et son utilisation, et procédé d'anesthésie d'un corps vivant grâce à celui-ci WO2021004367A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202090000741.9U CN218739871U (zh) 2019-07-10 2020-07-02 电场发生装置

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Application Number Priority Date Filing Date Title
CN201910619510.X 2019-07-10
CN201910619510 2019-07-10

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WO2021004367A1 true WO2021004367A1 (fr) 2021-01-14

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020099256A1 (en) * 2000-11-14 2002-07-25 Joseph Manne Electromagnetically induced anesthesia and sensory stimulation
CN101405083A (zh) * 2006-03-21 2009-04-08 皇家飞利浦电子股份有限公司 具有场电极的微电子装置
CN101500644A (zh) * 2006-06-19 2009-08-05 高地仪器公司 用于刺激生物组织的设备和方法
CN104888345A (zh) * 2015-05-07 2015-09-09 杨华 移动式电流神经麻醉装置
CN106267549A (zh) * 2016-08-24 2017-01-04 周玉梅 一种新型智能控制无痛感麻醉医疗设备
CN206120955U (zh) * 2016-08-23 2017-04-26 赵允起 新型电麻醉镇痛器

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090204173A1 (en) * 2007-11-05 2009-08-13 Zi-Ping Fang Multi-Frequency Neural Treatments and Associated Systems and Methods

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020099256A1 (en) * 2000-11-14 2002-07-25 Joseph Manne Electromagnetically induced anesthesia and sensory stimulation
CN101405083A (zh) * 2006-03-21 2009-04-08 皇家飞利浦电子股份有限公司 具有场电极的微电子装置
CN101500644A (zh) * 2006-06-19 2009-08-05 高地仪器公司 用于刺激生物组织的设备和方法
CN104888345A (zh) * 2015-05-07 2015-09-09 杨华 移动式电流神经麻醉装置
CN206120955U (zh) * 2016-08-23 2017-04-26 赵允起 新型电麻醉镇痛器
CN106267549A (zh) * 2016-08-24 2017-01-04 周玉梅 一种新型智能控制无痛感麻醉医疗设备

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CN218739871U (zh) 2023-03-28
CN112206407A (zh) 2021-01-12

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