WO2020252637A1 - 一种有利于修复晒伤肌肤的保养手膜 - Google Patents
一种有利于修复晒伤肌肤的保养手膜 Download PDFInfo
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- WO2020252637A1 WO2020252637A1 PCT/CN2019/091584 CN2019091584W WO2020252637A1 WO 2020252637 A1 WO2020252637 A1 WO 2020252637A1 CN 2019091584 W CN2019091584 W CN 2019091584W WO 2020252637 A1 WO2020252637 A1 WO 2020252637A1
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- skin
- repair
- sunburned
- beneficial
- sunburned skin
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- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims abstract description 30
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 15
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 15
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 15
- 229910001961 silver nitrate Inorganic materials 0.000 claims abstract description 15
- 239000007788 liquid Substances 0.000 claims abstract description 12
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 8
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 8
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 8
- 238000012423 maintenance Methods 0.000 claims description 26
- 230000009286 beneficial effect Effects 0.000 claims description 19
- 235000013305 food Nutrition 0.000 claims description 4
- 239000004745 nonwoven fabric Substances 0.000 claims description 3
- 239000011176 biofiber Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 6
- 229940069521 aloe extract Drugs 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 38
- 235000011399 aloe vera Nutrition 0.000 description 8
- 235000002961 Aloe barbadensis Nutrition 0.000 description 7
- 244000186892 Aloe vera Species 0.000 description 7
- 206010034972 Photosensitivity reaction Diseases 0.000 description 7
- 210000003414 extremity Anatomy 0.000 description 6
- 208000007578 phototoxic dermatitis Diseases 0.000 description 5
- 230000029663 wound healing Effects 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 3
- 206010042496 Sunburn Diseases 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
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- 206010040880 Skin irritation Diseases 0.000 description 2
- 206010070835 Skin sensitisation Diseases 0.000 description 2
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- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
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- AEMOLEFTQBMNLQ-WAXACMCWSA-N alpha-D-glucuronic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-WAXACMCWSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Definitions
- the invention relates to the technical field of skin care products, in particular to a hand care mask that is beneficial to repair sunburned skin.
- Photosensitive dermatitis is caused by the patient’s allergies to ultraviolet rays.
- the patient usually develops symptoms 1 to 2 days after sun exposure.
- the driver’s hands receive the most sunlight. Therefore, the back of the hand and the extended side of the upper limbs are prone to disease, manifested as redness, small papules, Small blisters and conscious itching, if not actively treated, can form chronic photosensitive skin diseases.
- Hyaluronic acid is a disaccharide unit composed of D-glucuronic acid and N-acetylglucosamine. It has the functions of regulating the permeability of blood vessel walls, regulating the diffusion and operation of water and electrolytes, and promoting wound healing, especially hyaluronic acid It is the best moisturizing substance in nature found so far. It is a good transdermal absorption enhancer while moisturizing.
- Hyaluronic acid can form a viscoelastic hydration film on the skin surface, which can make the skin stratum corneum smooth and moist, and block the intrusion of foreign bacteria, dust and ultraviolet rays, and protect the skin from damage; at the same time, hyaluronic acid It can penetrate into the skin epidermis, slightly expand capillaries, increase blood circulation, improve intermediate metabolism, promote skin nutrient absorption and waste discharge, and maintain the integrity of skin keratinous moisture and fiber structure. Hyaluronic acid plays an important role in wound healing. In the final stage of wound healing, increasing the HA content of the extracellular matrix helps reduce the deposition of collagen, thereby reducing scar formation. At the same time, in vitro studies have found that protein-containing hyaluronic acid preparations can significantly promote the proliferation of fibroblasts and the regeneration of epithelial tissues.
- Silver nitrate is a colorless crystal, easily soluble in water. Because it contains a large amount of silver ions, it is highly oxidizing and has a certain degree of corrosiveness. It is often used in medicine to corrode the proliferating granulation tissue. It has a powerful bactericidal effect. Kill more than 650 kinds of bacteria in a few minutes, broad-spectrum sterilization, and will not produce drug resistance, and can promote wound healing, cell growth and damaged cell repair.
- Aloe vera is a skin care and beauty product extracted from aloe. It has antibacterial and anti-inflammatory, detoxification, skin care, oil control and fat suppression effects. Most of the current sunscreen skin care products contain aloe vera, but from the perspective of the effect, when the skin has been After sunburn is damaged, using aloe vera solution is not enough to repair damaged skin.
- the purpose of the present invention is to provide a hand care mask that is beneficial to repair sunburned skin, so as to solve the problems raised in the background art.
- a maintenance hand mask beneficial to repair sunburned skin comprising two parts: a carrier and a maintenance liquid, wherein the content of each component of the maintenance liquid is:
- the molecular weight of the hyaluronic acid is 400,000-1,000,000, and the specification is pharmaceutical grade.
- the silver nitrate is of analytical grade.
- the sodium benzoate is a food grade specification.
- the carrier is one of non-woven fabric, silk film, and bio-fiber film.
- the preparation steps of the hand care mask that is beneficial to repairing sunburned skin of the present invention are:
- Silver nitrate has the effect of promoting wound healing, cell growth and repairing damaged cells.
- Hyaluronic acid and aloe vera liquid for moisturizing and sunscreen is no longer enough to repair the skin, it is still necessary to introduce some therapeutic components.
- the invention introduces a small amount of silver nitrate and has a good repairing effect on sunburned skin.
- a maintenance hand mask that is beneficial to repair sunburned skin, comprising two parts: a carrier and a maintenance liquid, wherein the content of each component of the maintenance liquid is:
- the molecular weight of the hyaluronic acid is 400,000-1,000,000, and the specification is pharmaceutical grade.
- the silver nitrate is of analytical grade.
- the sodium benzoate is a food grade specification.
- the carrier is a non-woven fabric.
- the preparation steps of the hand care mask that is beneficial to repairing sunburned skin of the present invention are:
- a maintenance hand mask that is beneficial to repair sunburned skin, comprising two parts: a carrier and a maintenance liquid, wherein the content of each component of the maintenance liquid is:
- the molecular weight of the hyaluronic acid is 400,000-1,000,000, and the specification is pharmaceutical grade.
- the silver nitrate is of analytical grade.
- the sodium benzoate is a food grade specification.
- the carrier is a silk film.
- the preparation steps of the hand care mask that is beneficial to repairing sunburned skin of the present invention are:
- the bacterial content, cytotoxicity, skin irritation, and skin sensitization of the hand care mask products obtained in Examples 1 and 2 are beneficial to repair sunburned skin.
- the test results are that the products of Examples 1 and 2 have no Bacteria detected; cytotoxicity is 0 safety level, no skin irritation, no skin sensitization.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
一种有利于修复晒伤肌肤的保养手膜，包括载体和保养液两部分，保养液各组分的含量为：透明质酸0.5-1％，芦荟原液5-10％，硝酸银0.01-0.05％，苯甲酸钠0.05％，余量为纯化水。在保养液中引入硝酸银组分，增强受损肌肤的修复作用，对晒伤肌肤具有良好的修复作用。
Description
本发明涉及护肤产品技术领域，具体涉及一种有利于修复晒伤肌肤的保养手膜。
随着人民生活质量的提高，开车的人越来越多，司机被晒得最多的地方就是手，很容易就被晒伤，这对爱美的人士尤其是女司机来说是个很大的问题。紫外线作用下，不仅会导致皮肤变黑长斑，还会引起光敏性皮炎。
光敏性皮炎是由于患者对紫外线过敏所致，患者通常在日晒后1～2天后发病，司机的手接受日光照射最多，因此手背及上肢伸侧很容易发病，表现为发红、小丘疹、小水疱、自觉瘙痒，如不积极治疗，可形成慢性光敏性皮肤病。
透明质酸是由D-葡萄糖醛酸及N-乙酰葡糖胺组成的双糖单位，具有调节血管壁的通透性，调节水电解质扩散及运转，促进创伤愈合等功效，特别是透明质酸是目前发现的自然界中保湿性最好的物质，在保湿的同时又是良好的透皮吸收促进剂。透明质酸可在皮肤表面形成一层粘弹性水化膜，该水化膜可以使皮肤角质层光滑湿润，并阻隔外来细菌、灰尘和紫外线的侵入，保护皮肤免受侵害；同时，透明质酸能渗入皮肤表皮层，轻微扩张毛细血管、增加血液循环、改善中间代谢、促进皮肤营养的吸收和废物的排放，保持皮肤角质水分及纤维结构的完整性。透明质酸对创伤愈合具有重要作用，在伤口愈合的最后阶段，提高细胞外基质的HA含量，有助于减少胶原蛋白的沉积，从而减少瘢痕形成。同时，体外研究发现，含有蛋白的透明质酸制剂对成纤 维细胞的增殖和上皮组织的再生作用具有明显的促进作用。
硝酸银是一种无色晶体，易溶于水，由于含有大量银离子，故氧化性较强，并有一定腐蚀性，医学上常用于腐蚀增生的肉芽组织，具有强大的杀菌功效，可在数分钟内杀死650多种细菌，广谱杀菌，而且不会产生耐药性，且能够促进伤口的愈合、细胞的生长及受损细胞的修复。
芦荟原液是从芦荟中提取的护肤美容产品，具有抑菌消炎、排毒护肤、控油抑脂的功效，目前的防晒护肤品中大部分都含有芦荟原液，但是从使用效果来看，当肌肤已经被晒伤受损后，再使用芦荟原液已经不足以修复受损的肌肤。
发明内容
本发明的目的在于提供一种有利于修复晒伤肌肤的保养手膜，以解决上述背景技术中提出的问题。
为实现上述目的，本发明提供如下技术方案：
一种有利于修复晒伤肌肤的保养手膜，包括载体和保养液两部分，其中，所述保养液各组分的含量为：
进一步，所述的透明质酸分子量为400000～1000000，规格为医药级。
进一步，所述硝酸银为分析纯规格。
进一步，所述苯甲酸钠为食品级规格。
进一步，所述的载体为无纺布、蚕丝薄膜、生物纤维薄膜其中之一。
本发明所述有利于修复晒伤肌肤的保养手膜的制备步骤为：
将透明质酸、芦荟原液、硝酸银、苯甲酸钠、纯化水混合后，在80℃条件下搅拌半小时至所有成分都融化混合均匀获得保养液，并用紫外线照射24小时消毒，然后在无菌条件下将载体浸润入保养液中15-30分钟，取出后分别独立包装，获得本发明所述有利于修复晒伤肌肤的保养手膜成品。
本发明的有益效果是：
1、在保养液中引入硝酸银组分，增强受损肌肤的修复作用：硝酸银具有促进伤口的愈合、细胞的生长及受损细胞的修复的功效，对晒伤肌肤来说，单纯的利用透明质酸和芦荟原液进行保湿防晒已经不足以修复肌肤，还是需要引入一些具有治疗效果的组分。本发明引入了少量的硝酸银，对晒伤肌肤具有良好的修复作用。
2、仅针对四肢肌肤研制，专膜专用：实践中可发现，光敏性皮炎主要发于四肢，对司机来说，则主要是发于手和手臂部位，这是因为四肢的皮肤构造和面部不同，且日常对面部的保养防护比四肢更为关注。正是因为四肢肌肤比面部肌肤厚一些，神经少一些，因此在本发明的保养液中引入少量硝酸银并不会产生什么副作用。本发明的有利于修复晒伤肌肤的保养手膜，仅用于四肢肌肤，专膜专用，主要是针对易发光敏性皮炎的女司机群体，在日常阳光下开车后及时使用，有利于修复晒伤的肌肤，减少日光下开车后的光敏性皮炎发病率和减轻发病程度。
下面给出本发明的具体实施例作详细说明。本实施例在以本发明技术方案为前提下进行实施，给出了详细的实施方式和具体的操作过程，但有必要在此指出的是，以下实施例只用于对本发明作进一步说明，不能理解为对本 发明保护范围的限制，该领域的专业技术人员根据上述本发明的内容做出的一些非本质的改进和调整，仍属于本发明的保护范围。
实施例1：
一种有利于修复晒伤肌肤的保养手膜，包括载体和保养液两部分，其中，所述保养液各组分的含量为：
进一步，所述的透明质酸分子量为400000～1000000，规格为医药级。
进一步，所述硝酸银为分析纯规格。
进一步，所述苯甲酸钠为食品级规格。
进一步，所述的载体为无纺布。
本发明所述有利于修复晒伤肌肤的保养手膜的制备步骤为：
将透明质酸、芦荟原液、硝酸银、苯甲酸钠、纯化水混合后，在80℃条件下搅拌半小时至所有成分都融化混合均匀获得保养液，并用紫外线照射24小时消毒，然后在无菌条件下将载体浸润入保养液中15-30分钟，取出后分别独立包装，获得本发明所述有利于修复晒伤肌肤的保养手膜成品。
实施例2：
一种有利于修复晒伤肌肤的保养手膜，包括载体和保养液两部分，其中，所述保养液各组分的含量为：
进一步，所述的透明质酸分子量为400000～1000000，规格为医药级。
进一步，所述硝酸银为分析纯规格。
进一步，所述苯甲酸钠为食品级规格。
进一步，所述的载体为蚕丝薄膜。
本发明所述有利于修复晒伤肌肤的保养手膜的制备步骤为：
将透明质酸、芦荟原液、硝酸银、苯甲酸钠、纯化水混合后，在80℃条件下搅拌半小时至所有成分都融化混合均匀获得保养液，并用紫外线照射24小时消毒，然后在无菌条件下将载体浸润入保养液中15-30分钟，取出后分别独立包装，获得本发明所述有利于修复晒伤肌肤的保养手膜成品。
实施例3：
检测实施例1和2获得的有利于修复晒伤肌肤的保养手膜产品的细菌含量、细胞毒性、是否刺激皮肤、是否令皮肤致敏，检测结果为，实施例1和2的产品，均没有检出细菌；细胞毒性均为0级安全级别，无皮肤刺激性，无皮肤致敏性。
实施例4：
选择5个有光敏性皮炎病史的试用者，告知在手和手臂皮肤经受阳光照射至少30分钟后，及时贴附实施例1和实施例2的产品，30天后试用者反馈试用体验，结果发现，使用本发明实施例1和2的产品，试用者光敏性皮炎发病率降低或者发病程度减轻，证明本发明的手膜对晒伤肌肤的修复有促进作用。且使用实施例1和实施例2的产品，对光敏性皮炎的防治效果没有显 著区别，但是实施例2的产品使用后手和手臂肌肤显得更光滑白皙一些。说明本发明的手膜产品，保养液的组分里引入少量硝酸银，能起到修复晒伤肌肤的作用，同时可以根据载体档次和各组分的添加比例，制备不同档次不同价格的产品。
对于本领域技术人员而言，显然本发明不限于上述示范性实施例的细节，而且在不背离本发明的精神或基本特征的情况下，能够以其他的具体形式实现本发明。因此，无论从哪一点来看，均应将实施例看作是示范性的，而且是非限制性的，本发明的范围由所附权利要求而不是上述说明限定，因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。不应将权利要求中的任何附图标记视为限制所涉及的权利要求。
此外，应当理解，虽然本说明书按照实施方式加以描述，但并非每个实施方式仅包含一个独立的技术方案，说明书的这种叙述方式仅仅是为清楚起见，本领域技术人员应当将说明书作为一个整体，各实施例中的技术方案也可以经适当组合，形成本领域技术人员可以理解的其他实施方式。
Claims (5)
- 一种有利于修复晒伤肌肤的保养手膜，其特征在于：包括载体和保养液两部分，其中，所述保养液各组分的含量为：
- 根据权利要求1所述的有利于修复晒伤肌肤的保养手膜，其特征是，所述的透明质酸分子量为400000～1000000，规格为医药级。
- 根据权利要求1所述的有利于修复晒伤肌肤的保养手膜，其特征是，所述硝酸银为分析纯规格。
- 根据权利要求1所述的有利于修复晒伤肌肤的保养手膜，其特征是，所述苯甲酸钠为食品级规格。
- 根据权利要求1所述的有利于修复晒伤肌肤的保养手膜，其特征是，所述的载体为无纺布、蚕丝薄膜、生物纤维薄膜其中之一。
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