WO2020246307A1 - Dispositif et procédé de fourniture d'informations de distance, dispositif et procédé de calcul de distance, et dispositif d'éjection de bulles - Google Patents

Dispositif et procédé de fourniture d'informations de distance, dispositif et procédé de calcul de distance, et dispositif d'éjection de bulles Download PDF

Info

Publication number
WO2020246307A1
WO2020246307A1 PCT/JP2020/020671 JP2020020671W WO2020246307A1 WO 2020246307 A1 WO2020246307 A1 WO 2020246307A1 JP 2020020671 W JP2020020671 W JP 2020020671W WO 2020246307 A1 WO2020246307 A1 WO 2020246307A1
Authority
WO
WIPO (PCT)
Prior art keywords
bubble ejection
distance
ejection device
bubble
tip
Prior art date
Application number
PCT/JP2020/020671
Other languages
English (en)
Japanese (ja)
Inventor
康裕 森泉
廣道 渡部
壮 眞壁
Original Assignee
株式会社ベックス
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社ベックス filed Critical 株式会社ベックス
Priority to JP2021524776A priority Critical patent/JP7438559B2/ja
Publication of WO2020246307A1 publication Critical patent/WO2020246307A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3203—Fluid jet cutting instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B7/00—Measuring arrangements characterised by the use of electric or magnetic techniques
    • G01B7/14—Measuring arrangements characterised by the use of electric or magnetic techniques for measuring distance or clearance between spaced objects or spaced apertures

Definitions

  • the disclosure in the present application relates to a distance information providing device that provides information for calculating the distance between the tip of the bubble ejection device and the bubble ejection object, a distance calculation device including the distance information providing device, and the bubble ejection device.
  • the present invention also relates to a distance information providing method for calculating the distance between the tip of the bubble ejecting device and the bubble ejecting object, and a distance calculation method including the distance information providing method.
  • retinal vein occlusion is a disease in which the vascular lumen is narrowed or occluded due to blood coagulation in the retinal vein.
  • a thrombus forms in a blood vessel, impaired venous blood return causes fundus hemorrhage, and the nerve elements of the retina degenerate due to hemorrhage and edema, often resulting in severe visual impairment.
  • the frequency of retinal vein occlusion has increased remarkably, and it has become one of the important diseases in ophthalmic clinical practice.
  • Non-Patent Document 1 As for research targeting vascular occlusion itself, research on a method of locally applying a physical stimulus from the outside of a blood vessel by the impact pressure of a microjet is known (see Non-Patent Document 1).
  • Non-Patent Document 1 As described in Non-Patent Document 1, research on locally giving physical stimulation to blood vessels from the outside by the impact pressure of a microjet is already known. And Non-Patent Document 1 describes an experimental method using a venous blood vessel of a chicken embryo having a diameter similar to that of a retinal vein having a diameter of about 120 ⁇ m as a model of a retinal vein.
  • Non-Patent Document 1 since the tip of the bubble ejection device is brought close to the chicken embryo placed in the container, the distance between the blood vessel and the tip of the bubble ejection device is performed by operating under a field of view such as a microscope. Can be adjusted. However, when the bubble ejection device is actually inserted into the eyeball, it is necessary to adjust the distance between the blood vessel and the tip of the bubble ejection device in the eyeball.
  • the distance between objects can be measured by a distance sensor that uses infrared rays or the like.
  • surgery should be as minimally invasive as possible. Therefore, it is desirable to make the devices to be inserted into the eyeball as small as possible and to reduce the number of devices to be inserted. Therefore, it is desirable that the distance between the bubble ejection device and the bubble ejection object can be calculated without using new devices such as a distance sensor, but such a device and method are not known at present.
  • the disclosure in this application relates to the following distance information providing device, distance calculating device, bubble ejection device, distance information providing method, and distance calculating method.
  • a distance information providing device that provides information for calculating the distance between the tip of the bubble ejection device and the bubble ejection object.
  • the distance information providing device is With a bubble ejection device, Electrical characteristic measurement unit and At least equipped with The bubble ejection device is Electrodes made of conductive material and An insulating material that covers at least the tip of the electrode, Including At least part of the insulating material forms a bubble spout, A gap covered with an insulating material is formed between the tip of the electrode and the bubble outlet.
  • the electrical characteristic measurement unit By measuring the electrical properties between the electrodes of the bubble ejection device and the counter electrode, it provides information for calculating the distance between the tip of the bubble ejection device and the bubble ejection object. Distance information providing device.
  • the electrical characteristic measuring unit measures the impedance between the electrode of the bubble ejection device and the counter electrode.
  • the electrical characteristic measuring unit measures the capacitance between the electrode of the bubble ejection device and the counter electrode.
  • the counter electrode is further included, and the counter electrode is Included as a separate body from the bubble ejection device, or Built into bubble ejection device, The distance information providing device according to any one of (1) to (3) above.
  • a distance calculation device for calculating the distance between the tip of the bubble ejection device and the bubble ejection object is The distance information providing device according to any one of (1) to (4) above, and Memory and Calculation unit and Including The memory is Stores calculation information obtained in advance for the relationship between the distance between the tip of the bubble ejection device and the bubble ejection object and the electrical characteristics. The calculation unit is By comparing the measured value measured by the electrical characteristic measurement unit with the calculation information, the distance between the tip of the bubble ejection device and the bubble ejection object is calculated. Distance calculation device.
  • the bubble ejection device according to (7) or (8) above.
  • a distance information providing method that provides information for calculating the distance between the tip of the bubble ejection device and the bubble ejection object.
  • the bubble ejection device is Electrodes made of conductive material and An insulating material that covers at least the tip of the electrode, Including At least part of the insulating material forms a bubble spout, A gap covered with an insulating material is formed between the tip of the electrode and the bubble outlet.
  • An electrical characteristic measurement process for measuring the electrical characteristics between the electrodes of the bubble ejection device and the counter electrode, Distance information providing method including at least.
  • a distance calculation method for calculating the distance between the tip of the bubble ejection device and the bubble ejection object is The electrical characteristic measurement value obtained by the distance information providing method described in (10) above is compared with the calculation information obtained in advance for the relationship between the distance between the tip of the bubble ejection device and the bubble ejection object and the electrical characteristic. By doing so, a distance calculation step of calculating the distance between the tip of the bubble ejection device and the bubble ejection object, Distance calculation method including at least.
  • information for calculating the distance between the tip of the bubble ejection device and the bubble ejection object by utilizing the configuration of the bubble ejection device. can be provided.
  • FIG. 1A is a diagram for explaining the outline of the distance information providing device 1A
  • FIG. 1B is a diagram for explaining the outline of the bubble ejection device 2.
  • FIG. 2 is a diagram for explaining the reason why the distance information E can be provided by using the distance information providing device 1A.
  • FIG. 3 is a flowchart showing the procedure of the distance information providing method.
  • FIG. 4 is a diagram for explaining the outline of the distance calculation device 1B.
  • FIG. 5 is a flowchart showing the procedure of the distance calculation method.
  • FIG. 6 is a diagram for explaining the outline of the bubble ejection device 1C according to the first embodiment.
  • FIG. 7 is a diagram for explaining the outline of the bubble ejection device 1D according to the second embodiment.
  • FIG. 8A to 8D are drawings-substituting photographs, which are photographs of the tip portion of various bubble ejection devices produced in Example 1.
  • FIG. 9 is a drawing substitute photograph
  • FIG. 9A is a photograph in which the tip 221 of the bubble ejection device 2 is in contact with the bubble ejection object S
  • FIG. 9B is a photograph in which the tip 221 of the bubble ejection device 2 is approximately from the bubble ejection object S. It is a photograph separated by 100 ⁇ m.
  • FIG. 10 is a graph when physiological saline is used as the conductive liquid L and impedance is measured as an electrical characteristic.
  • FIG. 11 is a graph when 20 mM KCl was used as the conductive liquid L and the impedance was measured as an electrical characteristic.
  • FIG. 9 is a drawing substitute photograph
  • FIG. 9A is a photograph in which the tip 221 of the bubble ejection device 2 is in contact with the bubble ejection object S
  • FIG. 9B is a
  • FIG. 12 is a graph when physiological saline is used as the conductive liquid L and the capacitance is measured as an electrical characteristic.
  • FIG. 13 is a graph when 20 mM KCl was used as the conductive liquid L and the capacitance was measured as an electrical characteristic.
  • the distance information providing device the distance calculating device, the bubble ejection device, the distance information providing method, and the embodiment of the distance calculating method will be described in detail with reference to the drawings.
  • members having the same type of function are designated by the same or similar reference numerals. Then, the repeated description of the members with the same or similar reference numerals may be omitted.
  • FIG. 1A is a diagram for explaining the outline of the distance information providing device 1A
  • FIG. 1B is a diagram for explaining the outline of the bubble ejection device 2.
  • the distance information providing device 1A includes at least a bubble ejection device 2 and an electrical characteristic measuring unit 3.
  • the bubble ejection device 2 includes an electrode 21 made of a conductive material and an insulating material 22 that covers at least the tip 211 of the electrode 21. Further, at least a part of the insulating material, in the example shown in FIG. 1B, a bubble outlet 23 is formed at the tip 221 of the insulating material 22. A gap 24 covered with an insulating material is formed between the tip 211 of the electrode 21 and the bubble outlet 23.
  • Reference numeral D in FIG. 1B represents the distance (gap of the gap 24) between the tip 211 of the electrode 21 and the bubble outlet 23.
  • the conductive material forming the electrode 21 is not particularly limited as long as it can conduct electricity and can be used as an electrode.
  • metals such as gold, silver, copper and aluminum can be mentioned.
  • an alloy obtained by adding a small amount of tin, magnesium, chromium, nickel, zirconium, iron, silicon or the like to the metal can be mentioned.
  • the insulating material 22 is not particularly limited as long as it insulates electricity.
  • inorganic insulating materials such as glass, mica, quartz, silicon nitride, silicon oxide, ceramics and alumina, rubber materials such as silicone rubber and ethylene propylene rubber, ethylene vinyl acetate copolymer resin, silane modified olefin resin and epoxy resin.
  • Polyester resin vinyl chloride resin, acrylic resin, melamine resin, phenol resin, polyurethane resin, polystyrene resin, fluororesin, silicon resin, polysulfide resin, polyamide resin, polyimide resin, polyethylene, polypropylene, cellulose resin , UV curable resin and other insulating resins.
  • the bubble ejection device 2 can be manufactured by inserting the electrode 21 into the tubular insulating material 22. In the case of producing by this method, it is desirable that the size of the electrode 21 and the size of the inner surface of the insulating material 22 are substantially the same so that no gap is generated between the electrode 21 and the inner surface of the insulating material 22.
  • the bubble ejection device 2 can also be manufactured by inserting the electrode 21 into the tubular insulating material 22 and heating and pulling it out. In this method, (1) the insulating material 22 is further stretched from the tip of the electrode 21 to form a gap 24 due to the difference in viscoelasticity between the insulating material 22 and the electrode 21, and (2) the insulating material 22 is the tip of the electrode 21.
  • the bubble ejection device 2 formed so as to be in close contact with the outer periphery of the 211 can be manufactured. More specifically, International Publication No. 2013/129657 can be referred to. The matters described in WO 2013/129657 are included herein.
  • the electrical characteristic measuring unit 3 measures the electrical characteristics between the electrode 21 of the bubble ejection device 2 and the counter electrode 4. As shown in Examples described later, when the distance E between the tip of the bubble ejection device 2 and the bubble ejection object S is changed, the measured value measured by the electrical characteristic measuring unit 3 changes. Therefore, the measured value measured by the electrical characteristic measuring unit 3 is information for calculating the distance E between the tip of the bubble ejection device 2 and the bubble ejection object S (hereinafter, information for calculating the distance E). It may be described as "distance information E").
  • the "tip of the bubble ejection device” means the tip 221 of the insulating material 22.
  • the term "tip portion of the bubble ejection device” when the term "tip portion of the bubble ejection device” is described, it means a portion on the tip end side of the bubble ejection device 2 including at least the tip 211 of the electrode 21.
  • the electrical characteristic measuring unit 3 is not particularly limited as long as it can measure the electrical characteristics between the electrode 21 of the bubble ejection device 2 and the counter electrode 4. Examples of electrical characteristics include impedance, capacitance, and the like.
  • the electric characteristic measuring unit 3 is not particularly limited as long as it can measure the above-exemplified electric characteristic.
  • a known impedance measuring device may be used when measuring impedance, and a known capacitance measuring device may be used when measuring capacitance.
  • a device capable of measuring the electrical characteristics may be used.
  • the distance information providing device 1A provides the distance information E from the electrical characteristic measuring unit 3. By operating the bubble ejection device 2 while a person compares the provided distance information E with the previously measured distance E and the relationship information of the electrical characteristics, the tip 221 of the bubble ejection device 2 and the bubble ejection object S The distance E between and can be adjusted to a desired distance.
  • the reason why the distance information E can be provided by using the distance information providing device 1A will be described with reference to FIG.
  • FIG. 2A when the tip 221 of the bubble ejection device 2 and the counter electrode 4 are immersed in the conductive liquid L, a circuit is formed between the electrode 21 of the bubble ejection device 2 and the counter electrode 4.
  • the bubble ejection object S has an electron e1 between the electrode 21 and the counter electrode 4. Does not obstruct the flow of.
  • FIG. 2A when the distance E between the tip 221 of the bubble ejection device 2 and the bubble ejection object S is long, the bubble ejection object S has an electron e1 between the electrode 21 and the counter electrode 4. Does not obstruct the flow of.
  • FIG. 2A when the distance E between the tip 221 of the bubble ejection device 2 and the bubble ejection object S is long, the bubble ejection object S has an electron e1 between the electrode 21 and the counter electrode 4. Does not obstruct the flow of.
  • the bubble ejection object S when the distance E is short, for example, when the tip 221 is in contact with the bubble ejection object S, the bubble ejection object S is an electron between the electrode 21 and the counter electrode 4. It obstructs the flow of e2. In other words, the shorter the distance E, the more difficult it is for electrons to flow between the electrode 21 and the counter electrode 4. Therefore, by measuring the electrical characteristics between the electrode 21 of the bubble ejection device 2 and the counter electrode 4, information for calculating the distance between the tip 221 of the bubble ejection device 2 and the bubble ejection object S can be obtained. Can be provided.
  • the distance information providing device 1A disclosed in the present application can provide the distance information E by utilizing the configuration of the bubble ejection device 2 itself.
  • the distance information E is provided according to the configuration of the bubble ejection device 2 itself and the distance to the bubble ejection object S without using a distance sensor or the like. Therefore, the distance information providing device is particularly useful for the bubble ejection target S in a place where the distance from the tip 221 of the bubble ejection device 2 is difficult to confirm, for example, the retinal vein in the eyeball, but the bubble ejection object S. Is not limited to retinal veins.
  • the distance information E is useful if the bubble ejection target S wants to adjust the distance of the bubble ejection device 2 from the tip 221 within a predetermined range.
  • Examples of the bubble ejection target S other than the retinal vein include blood vessels in the living body; stem cells, skin cells, mucosal cells, hepatocytes, pancreatic islet cells, nerve cells, chondrocytes isolated from human or non-human animal tissues. Examples thereof include endothelial cells, epithelial cells, bone cells, muscle cells, egg cells, etc., and cells such as plant cells, insect cells, Escherichia coli, yeast, mold; plants; animals; resins; substrates such as silicon; etc. However, it is not limited to these. If it can be ablated (cut) or injected (introduced) by ejecting bubbles, or its state can be changed by the stimulation of bubbles, it can be used as the bubble ejection object S.
  • the conductive liquid L is not particularly limited as long as electricity flows, and examples thereof include biological fluids, physiological salines, media, and other solutions containing ions.
  • the counter electrode 4 is described. However, the counter electrode 4 may be used when the distance information providing device 1A is used, and does not need to be provided as an essential configuration of the distance information providing device 1A.
  • the counter electrode 4 is not particularly limited as long as it conducts electricity, and the conductive material exemplified as the material for forming the electrode 21 may be used.
  • the counter electrode 4 When the counter electrode 4 is provided as a component of the distance information providing device 1A, it may be provided as a separate body from the bubble ejection device 2 as shown in FIGS. 1 and 2.
  • the bubble ejection device 4 is formed on the outside of the insulating material 22 (the surface in contact with the conductive liquid L) of the bubble ejection device 2 as shown in FIG. 2C. It may be one of the configurations of the device 2.
  • the counter electrode 4 is formed on the outside of the insulating material 22 of the bubble ejection device 2, it is desirable to form the energizing material into a thin film by vapor deposition or the like in order to avoid increasing the width of the bubble ejection device 2. ..
  • FIG. 3 is a flowchart showing the procedure of the distance information providing method.
  • the distance information providing method is carried out by using the bubble ejection device 2 described in the embodiment of the distance information providing device, the electrical characteristic measuring unit 3, and the counter electrode 4.
  • the distance information providing method includes a circuit forming step (S100) and an electrical characteristic measuring step (S110).
  • the bubble ejection device 2 is brought into contact with the conductive liquid by bringing the tip portion of the bubble ejection device 2 including the tip 211 of the electrode 21, the counter electrode 4 and the bubble ejection object S into contact with each other.
  • a circuit is formed between the electrode 21 and the counter electrode 4.
  • the electrical characteristic measurement step (S110) the electrical characteristic between the electrode 21 of the bubble ejection device 2 and the counter electrode 4 is measured. Then, by providing the measured value measured in the electrical characteristic measurement step (S110) as the distance information E, as described in the embodiment of the distance information providing device, the tip 221 of the bubble ejection device 2 and the bubble ejection object S The distance E between them can be adjusted to the desired distance.
  • FIG. 4 is a diagram for explaining the outline of the distance calculation device 1B.
  • the distance calculation device 1B includes a distance information providing device 1A, a storage unit 5, and a calculation unit 6. Since the distance information providing device 1A has already been described in the embodiment of the distance information providing device, detailed description thereof will be omitted.
  • the storage unit 5 stores calculation information obtained in advance for the relationship between the distance E and the electrical characteristics between the tip 221 of the bubble ejection device 2 and the bubble ejection object S.
  • the storage unit 5 is not particularly limited as long as it can store the calculation information, and a known storage device may be used.
  • the tip 221 of the bubble ejection device 2 and the bubble ejection object S Calculate the distance between.
  • the arithmetic unit 6 may use a known arithmetic unit.
  • the distance calculation device 1B may include a device that transmits the distance calculated by the calculation unit 6 to the operator of the bubble ejection device 2. For example, a display unit that displays the calculated distance and / or a vocalization unit that emits the distance as voice can be mentioned.
  • the distance information providing device 1A only provides the distance information E.
  • the distance calculation device 1B when the distance calculation device 1B is used, the distance between the tip 221 of the bubble ejection device 2 and the bubble ejection object S is calculated by comparing the measured value measured by the electrical characteristic measuring unit 3 with the calculation information. It has the effect of being able to do it.
  • FIG. 5 is a flowchart showing the procedure of the distance calculation method.
  • the distance calculation step (S120) is carried out after the distance information providing method is carried out, that is, after the circuit forming step (S100) and the electrical characteristic measurement step (S110) are carried out. Since the circuit forming step (S100) and the electrical characteristic measuring step (S110) have already been described in the embodiment of the distance information providing method, detailed description thereof will be omitted.
  • the distance calculation step (S120) the measured electrical characteristics (distance information E) obtained by the distance information providing method are used to determine the distance E and the electrical characteristics between the tip 221 of the bubble ejection device 2 and the bubble ejection object S.
  • the distance between the tip 221 of the bubble ejection device 2 and the bubble ejection object S is calculated by comparing the relationship with the calculation information obtained in advance.
  • the distance calculation method may include a distance transmission step of transmitting the calculated distance to the operator of the bubble ejection device 2. Examples of the distance transmission step include a display step of displaying the calculated distance and / or a vocalization step of emitting the distance as voice.
  • the distance information provision method is limited to the provision of distance information E.
  • the distance calculation method when used, the distance between the tip 221 of the bubble ejection device 2 and the bubble ejection object S can be calculated by comparing the measured value measured by the electrical characteristic measuring unit 3 with the calculation information. It plays the effect.
  • FIG. 6 is a diagram for explaining the outline of the bubble ejection device 1C according to the first embodiment.
  • the bubble ejection device 1C includes a distance calculation device 1B and a power supply device 7. Since the distance calculation device 1B has already been described in the embodiment of the distance calculation device, detailed description thereof will be omitted.
  • the power supply device 7 is not particularly limited as long as it can eject bubbles from the bubble ejection port 23 of the bubble ejection device 2 by applying electricity to the bubble ejection device 2 and the counter electrode 4, but the type of bubble ejection object S is limited. It is preferable that the strength of the ejected bubbles can be adjusted accordingly. Therefore, it is preferable that the power supply device 7 can appropriately adjust the applied current value, voltage value, and pulse width.
  • Examples of the power supply device 7 capable of adjusting the applied current value, voltage value, and pulse width include Hypercator 2000 (ConMed Co., Ltd.) and CFB16-HB (Bex Co., Ltd.), which are power supplies for general-purpose electric scalpels. It is not limited to these.
  • a non-inductive resistor, a voltage amplifier circuit, an input / output port (DIO; Digital Input Output), a control device such as a PC for controlling the power supply device 7, and the like may be provided, if necessary.
  • the bubble ejection device 1C an example including the distance calculation device 1B is shown as the bubble ejection device 1C, but the distance information providing device 1A may be included instead of the distance calculation device 1B.
  • the bubble ejection device 1C can be used for the treatment of vascular occlusion by ejecting bubbles. Therefore, the bubble ejection device 1C disclosed in this application can also be used as a thrombus treatment device.
  • the conventional bubble ejection device does not have a mechanism for measuring the distance E between the tip 221 of the bubble ejection device 2 and the bubble ejection object S.
  • the bubble ejection device 1C disclosed in the present application can adjust the distance E between the bubble ejection object S and the tip 221 of the bubble ejection device 2 by utilizing the configuration of the bubble ejection device 2 itself.
  • FIG. 7 is a diagram for explaining the outline of the bubble ejection device 1D according to the second embodiment.
  • the bubble ejection device 1D includes the bubble ejection device driving unit 8 and the control unit 9 in addition to the bubble ejection device 1C shown in FIG. Since the bubble ejection device 1C shown in FIG. 6 has already been described, detailed description thereof will be omitted.
  • the bubble ejection device driving unit 8 is not particularly limited as long as it is a device that holds the bubble ejection device 2 and can drive the held bubble ejection device 2.
  • a known mechanism such as an arm mechanism of a surgery support robot can be used.
  • the control unit 9 controls the bubble ejection device driving unit 8 so that the distance between the tip 221 of the bubble ejection device 2 and the bubble ejection object S is a desired distance.
  • the bubble ejection object S can be controlled.
  • the tip 221 of the bubble ejection device 2 can be arranged at a desired position.
  • the bubble ejection target S and the tip 221 of the bubble ejection device 2 are too close to each other, the force of the bubbles ejected to the bubble ejection object S may be too large, or the tip 221 of the bubble ejection device 2 may damage the bubble ejection object S. There is. On the other hand, if the bubble ejection target S and the tip 221 of the bubble ejection device 2 are too far apart, the influence of the bubbles on the bubble ejection object S becomes weak. Therefore, it is desirable to adjust the distance E on the order of ⁇ m, but when operated by a person, adjusting the position on the order of ⁇ m requires skillful technique. Since the bubble ejection device 1D according to the second embodiment can automate the driving of the bubble ejection device 2, it has an effect of improving the operability of the bubble ejection device 2.
  • Example 1 A distance information providing device was manufactured by the following procedure.
  • a fluororesin tube (manufactured by Hagitec Co., Ltd.) having a diameter of about 300 ⁇ m and an inner diameter of about 100 ⁇ m was used.
  • Tungsten (manufactured by Nirako Co., Ltd.) having a diameter of about 100 ⁇ m was used for the electrode 21.
  • the bubble ejection device 2 was manufactured by inserting a tungsten electrode into the fluororesin tube. A plurality of types of bubble ejection devices 2 having different gaps D (distance between the tip 211 of the electrode 21 and the bubble ejection port 23) were produced.
  • FIG. 8 is a photograph of the tip portion of the produced bubble ejection device 2.
  • the gap D of the bubble ejection device 2 shown in FIG. 8A was 0 ⁇ m.
  • the gap D of the bubble ejection device 2 shown in FIG. 8B was 10 ⁇ m.
  • the gap D of the bubble ejection device 2 shown in FIG. 8C was 30 ⁇ m.
  • the gap D of the bubble ejection device 2 shown in FIG. 8D was 100 ⁇ m.
  • three bubble ejection devices 2 having the same gap were produced for each gap.
  • the counter electrode 4 was processed into a 1-pin connector (5289-2A, manufactured by Molex Japan).
  • an LCR meter Hioki Electric Co., Ltd., IM3536
  • an LCR meter Hioki Electric Co., Ltd., IM3536
  • a distance information providing device was manufactured by connecting the electrode 21 and the counter electrode 4 of the bubble ejection device 2 to the electrical characteristic measuring unit 3 using an electric wire.
  • Example 2 The distance information providing method was carried out using the produced distance information providing device according to the following procedure.
  • [Experimental material] -For the conductive liquid L, physiological saline (manufactured by Otsuka Pharmaceutical Co., Ltd.) and 20 mM KCl (0.298 g of special grade reagent KCl manufactured by Fujifilm Wako Pure Chemical Industries, Ltd. were dissolved in pure water to make 200 mL) were used.
  • An acrylic plate (10 mm ⁇ 15 mm, thickness 2 mm) was used as the bubble ejection target S.
  • FIG. 9A is a photograph showing a state in which the tip 221 and the bubble ejection object S are in contact with each other, and the portion indicated by the arrow in the photograph is the contact surface. Then, by operating the memory of the micromanipulator, the tip 221 was separated from the bubble ejection target S.
  • FIG. 9B is a photograph when the tip 221 is separated by about 100 ⁇ m. In FIG. 9B, the arrow on the left side represents the bubble ejection object S, and the arrow on the right side represents the tip 221 of the bubble ejection device 2.
  • the tip 221 and the bubble ejection object S were set at a predetermined distance, and the impedance and capacitance were measured by the electrical characteristic measuring unit 3.
  • FIG. 10 is a graph when physiological saline is used as the conductive liquid L and impedance is measured as an electrical characteristic.
  • the horizontal axis represents the distance between the bubble ejection object S and the tip 221 of the bubble ejection device 2, and the vertical axis represents the measured impedance value.
  • FIG. 11 is the same as FIG. 10 except that 20 mM KCl was used as the conductive liquid L instead of physiological saline.
  • FIG. 12 is a graph when physiological saline is used as the conductive liquid L and the capacitance is measured as an electrical characteristic.
  • the horizontal axis represents the distance between the bubble ejection object S and the tip 221 of the bubble ejection device 2, and the vertical axis represents the measured value of capacitance.
  • FIG. 13 is the same as FIG. 12 except that 20 mM KCl was used as the conductive liquid L instead of physiological saline.
  • the measured value changes according to the distance between the bubble ejection object S and the tip 221 of the bubble ejection device 2 regardless of whether impedance or capacitance is measured as an electrical characteristic. Confirmed to do. Although it depends on the electrical characteristics, the conductive liquid, and the size of the gap, the electrical characteristics change when the distance between the bubble ejection object S and the tip 221 of the bubble ejection device 2 is about 0 ⁇ m to about 200 ⁇ m. Was big. Although it depends on the type of the bubble ejection object S, the distance between the bubble ejection object S and the tip 221 of the bubble ejection device 2 is preferably about 200 ⁇ m.
  • the tip 221 of the bubble ejecting device 2 and the bubble ejecting object S are used by utilizing the configuration of the bubble ejecting device 2. It was confirmed that information for calculating the distance could be provided.
  • Example 2 It was also clarified from the results of Example 2 that the measured values of electrical characteristics differ depending on the type of conductive liquid and the size of the gap. Therefore, when the bubble ejection device 2 having a plurality of types of gap sizes is used, or when the usage environment is different (the type of the conductive liquid L is different), the calculation information according to the gap size and the usage environment is provided. It also became clear that it is desirable to prepare in advance.
  • the distance between the tip 221 of the bubble ejection device 2 and the bubble ejection object S is arranged so as to be a desired distance. It becomes possible. Therefore, it is useful in the medical industry, the processing industry that requires fine processing, the agriculture, forestry and fisheries fields, and the like.

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Vascular Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

La présente invention aborde le problème consistant à fournir un dispositif de fourniture d'informations de distance qui fournit des informations pour calculer la distance entre l'extrémité distale d'un dispositif d'éjection de bulles et une substance soumise à l'éjection de bulles, le dispositif de fourniture d'informations de distance permettant d'utiliser une configuration fournie à un dispositif d'éjection de bulles.　Le problème mentionné ci-dessus est résolu par un dispositif de fourniture d'informations de distance qui fournit des informations pour calculer la distance entre l'extrémité distale d'un dispositif d'éjection de bulles et une substance soumise à une éjection de bulles, dans lequel : le dispositif de fourniture d'informations de distance comprend au moins un dispositif d'éjection de bulles et une unité de mesure de caractéristique électrique ; le dispositif d'éjection de bulles comprend une électrode formée à partir d'un matériau électroconducteur, et un matériau isolant qui recouvre au moins la partie d'extrémité distale de l'électrode ; au moins une partie du matériau d'isolation forme une ouverture d'éjection de bulles ; un espace couvert par le matériau d'isolation est formé entre l'extrémité distale de l'électrode et l'ouverture d'éjection de bulles ; et l'unité de mesure de caractéristique électrique mesure les caractéristiques électriques entre l'électrode du dispositif d'éjection de bulles et une contre-électrode, fournissant ainsi des informations pour calculer la distance entre l'extrémité distale du dispositif d'éjection de bulles et la substance soumise à l'éjection de bulles.
PCT/JP2020/020671 2019-06-02 2020-05-26 Dispositif et procédé de fourniture d'informations de distance, dispositif et procédé de calcul de distance, et dispositif d'éjection de bulles WO2020246307A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021524776A JP7438559B2 (ja) 2019-06-02 2020-05-26 距離情報提供装置、距離算出装置、気泡噴出装置、距離情報提供方法、および、距離算出方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019103416 2019-06-02
JP2019-103416 2019-06-02

Publications (1)

Publication Number Publication Date
WO2020246307A1 true WO2020246307A1 (fr) 2020-12-10

Family

ID=73652104

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2020/020671 WO2020246307A1 (fr) 2019-06-02 2020-05-26 Dispositif et procédé de fourniture d'informations de distance, dispositif et procédé de calcul de distance, et dispositif d'éjection de bulles

Country Status (2)

Country Link
JP (1) JP7438559B2 (fr)
WO (1) WO2020246307A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013129657A1 (fr) * 2012-03-02 2013-09-06 独立行政法人科学技術振興機構 Appareil de pulvérisation de bulles et son procédé de production, appareil de pulvérisation de gaz et de liquide et son procédé de production, dispositif d'ablation locale et procédé d'ablation locale, dispositif d'injection locale, appareil de pulvérisation de bulles au plasma et dispositif de cicatrisation et procédé de cicatrisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11242610B2 (en) 2017-10-19 2022-02-08 Kyushu University, National University Corporation Plating method, bubble ejection member, plating apparatus, and device

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013129657A1 (fr) * 2012-03-02 2013-09-06 独立行政法人科学技術振興機構 Appareil de pulvérisation de bulles et son procédé de production, appareil de pulvérisation de gaz et de liquide et son procédé de production, dispositif d'ablation locale et procédé d'ablation locale, dispositif d'injection locale, appareil de pulvérisation de bulles au plasma et dispositif de cicatrisation et procédé de cicatrisation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SUMIMOTO ET AL.: "Reperfusion of microvascular occlusion by physical stimuli of electrical-induced bubble", LECTURE PROCEEDINGS OF 2018 ROBOTICS AND MECHATRONICS CONFERENCE, THE JAPAN SOCIETY OF MECHANICAL ENGINEERS, 30 November 2018 (2018-11-30) *

Also Published As

Publication number Publication date
JP7438559B2 (ja) 2024-02-27
JPWO2020246307A1 (fr) 2020-12-10

Similar Documents

Publication Publication Date Title
US10369360B2 (en) Devices for material delivery, electroporation, sonoporation, and/or monitoring electrophysiological activity
KR102227429B1 (ko) 치료제 전달을 위한 진입 수포를 형성하는 장치 및 방법
CN111801062A (zh) 局灶脉冲场消融设备和方法
EP3154463B1 (fr) Appareil d'ablation transurétrale de tissu rapide et sélective
DE60114505T2 (de) Katheter mit verbesserter Ablationselektrode
JP4091282B2 (ja) 液化破砕ハンドピース及びそのチップ
US9566456B2 (en) Ultrasound transceiver and cooling thereof
KR102205295B1 (ko) 곡침을 통해 치료제를 망막하 투여하기 위한 장치
US20120095371A1 (en) Ultrasound transducer and cooling thereof
JP2004500917A (ja) 吸引安定化心外膜切除装置
JP2009527321A (ja) 薬剤の細胞中へのアバランシェ媒介導入のための方法および装置
JP2019505308A (ja) 空洞性組織アブレーションシステム
JP2007537013A (ja) 高密度焦点式超音波を使用してアブレートした組織領域を形成する方法
ES2742275T3 (es) Ablación de corta duración con temperatura controlada
JP2022101690A (ja) 治療薬の網膜下送達のための注入装置
JP2021166802A (ja) 温度制御された短時間アブレーション
JP6980390B2 (ja) 温度制御された短時間アブレーション
JP2010503477A (ja) 組織の種類を識別するための方法および装置
CN111629682A (zh) 定向聚焦的消融设备
US20200078214A1 (en) Systems and methods for pulsed posterior vitreous detachment creation
WO2020246307A1 (fr) Dispositif et procédé de fourniture d'informations de distance, dispositif et procédé de calcul de distance, et dispositif d'éjection de bulles
US20060229585A1 (en) Drug delivery to the crystalline lens and other ocular structures
JP2016032523A (ja) 細胞組織離断方法
US20200155348A1 (en) Capsulorhexis apparatus
Satava et al. Disruptive visions: biosurgery

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 20819484

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2021524776

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 20819484

Country of ref document: EP

Kind code of ref document: A1