WO2020244575A1 - 驻极体产品、其制备方法、使用方法及相关用途 - Google Patents

驻极体产品、其制备方法、使用方法及相关用途 Download PDF

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Publication number
WO2020244575A1
WO2020244575A1 PCT/CN2020/094380 CN2020094380W WO2020244575A1 WO 2020244575 A1 WO2020244575 A1 WO 2020244575A1 CN 2020094380 W CN2020094380 W CN 2020094380W WO 2020244575 A1 WO2020244575 A1 WO 2020244575A1
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electric field
electret
guided
product
poles
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PCT/CN2020/094380
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English (en)
French (fr)
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唐万福
奚勇
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上海必修福企业管理有限公司
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Publication of WO2020244575A1 publication Critical patent/WO2020244575A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/10—Applying static electricity

Definitions

  • the invention relates to an electret product, its preparation method, use method and related uses.
  • Electric field treatment of tumor technology is a comprehensive subject that applies electricity to the treatment of malignant tumors. It has been nearly a century since the effect of electric field on tumor cells was proposed. With the maturity of the theory, people have begun to apply electric field in clinical treatment of tumors. At present, the following three electric field technologies are mainly studied at home and abroad: DC electric field, tumor treating fields (TT-Fields), and DC pulsed electric field.
  • the AC electric field has been widely used in many fields such as disease diagnosis, scientific research and environmental protection.
  • Low-frequency AC electric fields below 103z can make cells generate action potentials, which are used to stimulate the bioelectric activity of nerves or muscles;
  • high-frequency AC electric fields above 106Hz have a thermal effect on some cells or tissues.
  • Intermediate frequency AC electric fields between 10 3 Hz and 106 Hz will neither cause depolarization nor large dielectric consumption, and can interfere with cell mitosis.
  • Some charged molecules (such as proteins, peptides, DNA, etc.) in the cell will oscillate with the change of the AC electric field.
  • the force will make the direction of movement of charged molecules parallel to the direction of the electric field.
  • a dipole is a molecule separated from the cathode and the anode, and its direction is consistent with the direction of the electric field. Almost all charged molecules move in the direction of the field strength in the constantly changing AC electric field.
  • the division groove is divided into two daughter cells connected by narrow cytoplasm. An uneven electric field is formed near the connection site. Polar molecules move toward the direction of field strength, thereby affecting mitosis.
  • the role of the spindle in mitosis is to divide the sister chromatids evenly into two daughter cells.
  • the microtubule subunits are arranged in parallel according to the direction of the electric field.
  • tubulin is subjected to an electric field with a suitable strength to cause polymerization barriers, which hinder the formation of microtubules. This leads to cell fragmentation.
  • TT-Fields is to place the insulated electrode sheet on the skin around the malignant tumor growth site to provide an electric field.
  • the electric field device works 18 hours a day on average to form two mutually perpendicular alternating electric fields with a strength of 1-2V/cm and a frequency of 200kHz. . It can cover almost all areas of the human body that may be affected, and has no effect on non-differentiated cells. According to reports, in TT-Fields treatment, apart from the contact of the electrode patch in the treatment device with the skin, which may cause local dermatitis, no other side effects have been found. In addition, some studies have pointed out that TT-Fields has low toxicity and good patient response, with high degree of co-treatment.
  • Direct current electric field therapy is electrochemical therapy, which uses electrodes as cathodes and anodes to insert into tumor tissues, and continuously energizes to produce electrolytic ionization, electrophoresis and electroosmosis and other electrochemical reactions to achieve the purpose of destroying or affecting tumor cells.
  • electrochemical therapy uses electrodes as cathodes and anodes to insert into tumor tissues, and continuously energizes to produce electrolytic ionization, electrophoresis and electroosmosis and other electrochemical reactions to achieve the purpose of destroying or affecting tumor cells.
  • the main principle may be that after electrochemical treatment, the pH value of the tissue around the electrode changes significantly, forcibly changing the tumor cells The pH value of surrounding tissues and surrounding tissues.
  • the pulsed electric field contains a variety of frequencies from low to high, and the action time is very short.
  • the biological effect caused is very different from the DC electric field or electrostatic field.
  • the cell can quickly reach the maximum membrane voltage under the action of this external electric field. Due to the electric field stress, it will become thinner and will be broken down to produce electroporation when it reaches a certain critical point.
  • the applied instantaneous pulsed electric field intensity is greater than 1kV/cm, the permeability of the molecules in the cell will be greatly increased; if the pulsed electric field intensity continues to increase, the cell membrane will undergo irreversible electroporation.
  • Pulsed electric fields can be divided into two categories, as follows:
  • Electric pulse chemotheraoy is a tumor treatment method that combines the action of pulsed electric field with chemical drugs.
  • Low-intensity pulsed electric fields can cause reversible electroporation of cell membranes, increase the permeability of cell membranes, and increase the exchange of internal and external molecules, which is conducive to local drug delivery.
  • the degree of cell membrane penetration depends on the intensity and duration of the pulsed electric field, the size of the target cell, and so on.
  • the therapeutic effect of EPCT on superficial tumors such as skin or subcutaneous area has been confirmed, but there is no relevant result on the therapeutic effect of deep tumors.
  • Nanosecond pulsed electric fields refers to a steep pulse electric field with a pulse width of the order of nanoseconds, which can cause irreversible electroporation of tumor cell membranes.
  • nsPEF nanosecond pulsed electric fields
  • the present invention provides an electret product that can be used to guide substances to be guided by an electric field and can provide an effective, durable and safe electric field, a preparation method, a use method and related uses.
  • An object of the present invention is to provide an electret product, which is characterized by comprising:
  • Electret material used for electric field electret Two electric field poles are formed in the electret product, and an electric field is formed between the two poles.
  • the two poles are distributed on two opposite faces of the electret material.
  • the electret product of the present invention after the electric field electrets, two electric field poles are formed in the electret material, and an electric field is formed between the two poles, and then the electret is prepared from the electret material Body products.
  • the electric field voltage is 0.1-33000 volts.
  • the electric field electret adopts a high-voltage electret, and/or the formed electric field is a direct current electric field.
  • the electret product of the present invention wherein, the electret product is a fabric.
  • the fabric is used to make medical patches, wearing articles, bedding, auxiliary materials for the preparation of clothing, adhesives for the preparation of clothing or One or more of the silk threads needed to prepare clothing.
  • the electret material is an electret film material.
  • the electret membrane material is one or more of polytetrafluoroethylene membrane material, glass fiber membrane material or alumina membrane material.
  • the present invention also provides a method for preparing electret products, which is characterized in that: two electric field poles are formed in the electret material after the electric field electret, and an electric field is formed between the two poles, and then the electret material is prepared An electret product is obtained, wherein the electret product is the above-mentioned electret product.
  • the electric field electret process is as follows:
  • the electret material placed on the positive electrode, flat, not bulging or uneven; move the corona wire parallel to the top, and repeatedly electret the electret material in one direction.
  • the distance between the corona wire and the electret material should be strictly controlled to prevent the material from being burned by the glow discharge, and the distance between 12 kV/cm should be basically maintained. After such a number of uniform electrets, the electret is successfully charged in about 10 minutes, and the electret power is finally measured to be 0.1-33000 kV.
  • the electric field direction of the electret materials should be consistent, keep the material dry, and avoid the direction of the electric field from being reversed.
  • the direction of the electric field of the material is the same, that is, all the negative electrodes are flushed out, and the positive electrodes are facing in.
  • the present invention also provides a method for using electret products, which is characterized in that it includes:
  • Step 1 contact one of the two poles of the electric field of the electret product with the skin of the organism; Step 2, make the tissue in the organism become an equal electrode of one of the two poles of the electric field through the skin charge conduction; Step 3, pass the electric field
  • the force guidance makes the specific electric field to guide the material to move, wherein the electret product is the aforementioned electret product.
  • step 3 the specific material to be guided by the electric field is located in the organism, and the material to be guided by the electric field is neutral or has a charge opposite to the other pole of the electric field, etc.
  • the substance to be guided by the electric field carries a charge opposite to the other of the two poles of the electric field and moves to the other of the two poles of the electric field under the force of the electric field.
  • the substance to be guided by the electric field is water or a specific ion sensitive to electric field force.
  • one of the two poles of the electric field is positive, and the other of the two poles of the electric field is negative.
  • step 3 the specific electric field guide substance is located outside the organism, the electric field guide substance is neutral or has a charge opposite to the equal electrode, and the other of the electric field guides After the electric charge is conducted between the electrode and the material to be guided by the electric field, the material to be guided by the electric field carries the opposite charge to the equal electrode and moves to the equal electrode under the action of the electric field force.
  • the substance to be guided by the electric field is an ionic drug or a water-containing substance.
  • the present invention also provides a use of electret materials in preparing electret products, which is characterized in that the electret products are the above-mentioned electret products.
  • the electret product is used for one or more of electric field guided substance guidance or tumor preventive treatment.
  • the substance to be guided by the electric field is ion or water.
  • the material to be guided by the electric field is used for one or more of the following:
  • the specific ion is a high-valent ion or a heavy metal ion.
  • the specific ions are Zr 4+ , Al 3+ , Fe 3+ , Cr 3+ , Ti 4+ , high-valent ions of mercury, high-valent ions of lead, and high-valent ions of copper
  • the specific ions are Zr 4+ , Al 3+ , Fe 3+ , Cr 3+ , Ti 4+ , high-valent ions of mercury, high-valent ions of lead, and high-valent ions of copper
  • the specific ions are Zr 4+ , Al 3+ , Fe 3+ , Cr 3+ , Ti 4+ , high-valent ions of mercury, high-valent ions of lead, and high-valent ions of copper
  • ions, high-valent ions of chromium, high-valent ions of arsenic, and high-valent ions of cadmium are Zr 4+ , Al 3+ , Fe 3+ , Cr 3+ , Ti 4+ , high-valent ions of mercury, high-valent ions of lead, and high-valent
  • Another object of the present invention is to provide one or more uses of electret products in the guidance of electric field-guided substances, tumor prevention and treatment or neurological disease treatment, characterized in that the electret products are the above-mentioned electret products.
  • Polar body products are the above-mentioned electret products.
  • the substance to be guided by an electric field includes one or more of water, ionic drugs, water-containing substances, high-valent ions, or heavy metal ions; in an example of this use, wherein the specific The ions are Zr 4+ , Al 3+ , Fe 3+ , Cr 3+ , Ti 4+ , high-valent ions of mercury, high-valent ions of lead, high-valent ions of copper, high-valent ions of chromium, high-valent ions of arsenic, and high-valent cadmium One or more of the ions.
  • the guidance of the substance to be guided by the electric field is used for one or more of the following:
  • the electret product According to the electret product provided by the present invention, its preparation method, use method and related uses, since the obtained electret product includes electret material for electret, and electric field two poles are formed in the electret product, And an electric field is formed between the two poles, so that in use, when one of the two poles of the electric field is in contact with the skin of the organism, a corresponding equal-potential electrode can be formed, so that the organism and the other electrode of the stationary material can be formed Electric field, the material to be guided by the electric field can move towards the opposite pole under the action of the electric field force, so that the material to be guided by the electric field in the organism can be guided to move, or the electric field outside the organism can be guided.
  • the substance is introduced into the organism, and because the electret product has two poles, the electret is stable and can effectively maintain the electric field for a long time, which can replace the active electric field, making the actual use more convenient, safe and effective, and due to the price of the electret material Low cost, universal use, non-toxic and safe.
  • Figure 1 is a schematic side sectional view of the electret product involved in embodiment 1;
  • FIG. 2 is a schematic diagram of the use of the electret product involved in Example 1;
  • Figure 3 is a schematic side sectional view of the electret product involved in embodiment 2;
  • Example 4 is a schematic diagram of the use of the electret product involved in Example 2.
  • the electric field force is the force that the charged material in the electric field can be attracted by the opposite pole and repelled by the same pole.
  • the magnitude of the electric field force depends on the voltage of the electric field and the amount of charge of the substance.
  • the charged substance to be guided by the electric field is the charged substance.
  • Fig. 1 is a schematic side sectional view of an electret product related to Example 1.
  • the electret product 100 provided by this embodiment includes: an electret material 10 for electric field electret, that is, the electret is an electret material that allows electrodes to reside in the material.
  • the electric field thereby also forming electric field poles in the electret product 100, that is, one pole 11 of the electric field poles and the other pole 12 of the electric field two poles, and an electric field is formed between the two poles.
  • one The pole 11 is a positive electrode 11 and the other pole 12 is a negative electrode 12, and the two poles 11 and 12 are distributed on two opposite faces 14 and 15 of the electret material 10.
  • two electric field poles 11 and 12 are formed in the electret material 10 after the electric field electret, and an electric field is formed between the two poles, and then the electret product 100 is prepared from the electret material 10.
  • the obtained electric field voltage (static voltage) is preferably 0.1-33000 volts.
  • the above-mentioned electric field electret adopts high voltage for electret, and/or the formed electric field is a direct current electric field.
  • the electret product 100 is a fabric, which can be used to make medical patches, wearables, bedding, auxiliary materials for the preparation of clothing, adhesives for the preparation of clothing, or One or more of the silk threads needed to prepare clothing.
  • Wearable items can be electret field suits, that is, clothing with electret electric fields.
  • the electret field suit can be selected from underwear or outerwear.
  • the underwear may be a brassiere.
  • the electret electric field suit includes: electret material fabric made of electret material, and auxiliary materials, adhesives, and threads required to make the electret material fabric into clothing.
  • the electret field suit can be made after the electret, or the electret material fabric can be electretized and then made into the electret field suit.
  • the electret electric field suit includes: fabric and inner lining made of electret material. According to the electric field distribution of the electret material, the patches, underwear, outerwear, and bedding are made into the same patches as normal clothes. The electric field is distributed on the inside and outside of these fabrics or linings. The side close to the skin is the positive electrode, and the effective therapeutic electric field is from the negative electrode to the positive electrode. Due to the conduction of the electric charge in the body, the electric field of the negative electrode outside the electret fabric and the internal material (organism tissue) is formed. The measured potential is 0.03 volts to 3000 volts.
  • the dielectric is polarized when placed in an electric field.
  • the polarization of many dielectrics disappears at the same time as the external electric field.
  • This kind of dielectric that is polarized and can “permanently” maintain the polarization state under the action of a strong external electric field and other factors is called an electret or a permanent electric body.
  • the electret material is the material with this characteristic.
  • the electret material in this embodiment is an electret membrane material.
  • the electret membrane material can be polytetrafluoroethylene membrane material, glass fiber material, alumina material, etc., among which the PTFE membrane material is easy to Electret, stable chemical properties, harmless to skin contact, soft and transparent material, suitable for skin contact.
  • the corona discharge method can make electret materials such as polytetrafluoroethylene semi-permanently charged, the electrostatic voltage generated by this electret will be 0.1-33000 volts; an effective electric field can be established. Due to the difference in the material lattice and the difference in textiles, the polarity direction will be different after the electric field is formed. The disordered electric field direction will make the electret material's electric field function disorderly and cannot produce an effective electric field effect. For this reason, after selecting the electret, the electric field direction will be the same , The same electrode is unified on one end face or one part, so that the electric field can be established and will not disappear.
  • the electret material after the electret is made into medical patches, wearable articles, bedding, auxiliary materials for the preparation of clothing, and bonding for the preparation of clothing
  • One or more electret products used in the preparation of the silk thread required for the preparation of clothing, the electric field poles are respectively located on two end faces, that is, two opposite faces 14 and 15.
  • the positive and negative electrodes that form the electric field. Between the positive and negative electrodes, an electrostatic field is formed. Place the patch close to the area to be suppressed. The patch generates a permanent and safe electrostatic field, which acts on the part of the organism.
  • the preparation method of the electret product 100 provided in this embodiment after the electric field electrets, two electric field poles 11 and 12 are formed in the electret material, and an electric field is formed between the two poles, and then prepared from the electret material Electret products.
  • the distance between the corona wire and the electret material should be strictly controlled during electret to avoid the glow discharge burning the material, and basically keep 12 kV/ Centimeter spacing. After several times of uniform electrets, the electret is successfully charged in about 10 minutes, and the final measured electret power is 0.1-33000 kV, preferably 3-4 kV.
  • the uniformity of the electric field direction of the electret material keeps the material dry and avoids the electric field direction from being reversed.
  • the direction of the electric field of the material is always that all the negative electrodes face outwards and the positive electrodes face inwards;
  • FIG. 2 is a schematic diagram of the use of the electret product involved in Example 1.
  • FIG. 2 is a schematic diagram of the use of the electret product involved in Example 1.
  • the skin 1 of a living body is shown (indicated by a broken line), and the left side of the skin shows tissues in the living body, for example, other skin tissues close to the epidermis of the skin 1.
  • the method of using the electret product 100 provided in this embodiment includes:
  • Step 1 One pole 11 of the two electric field poles of the electret product 100 is in contact with the skin 1 of the organism.
  • the positive electrode 11 is in contact with the skin 1 of the organism;
  • Step 2 Conduct the electrons of the one pole 11 to the tissue in the living body through the skin 1 so that the tissue in the body becomes the equal electrode 13 of the one pole 11, which is equivalent to the equal electrode 13 and the other electrode 12 of the two poles.
  • An electric field is established between, in this embodiment, that is, this electric field is established between the tissue and the surface 14 in the living body;
  • Step 3 the specific material to be guided by the electric field is guided by the electric field force to move in a directional direction.
  • the other electrode 12 is the negative electrode 12.
  • the specific material to be guided by the electric field can be divided into the inside or outside of the organism. , Being in the body means that the substance to be guided by the electric field is already in the body, and being outside the body means that the substance to be guided by the electric field has not entered the body.
  • the substance to be guided by an electric field needs to be neutral or have a charge opposite to the other pole 12 of the electric field.
  • the neutral material to be guided by the electric field receives the charge from the equal electrode 13 and carries it with the other electrode 13
  • One pole 12 has the opposite charge, so the material to be guided by the electric field can move toward the other pole 12 under the force of the electric field;
  • the electric field guide substance accepts the electric charge from the iso-electrode 13 so that its tendency to move toward the other pole 12 in a direction intensifies.
  • the substance to be guided by an electric field is neutral or has a charge opposite to that of the equivalent electrode 13, so that it passes through the other electrode 12 and
  • the electric charge conduction between the materials to be guided by the electric field can make the neutral material to be guided by the electric field have the opposite charge to the equal electrode 13, or can make the material to be guided by the electric field with the opposite charge to the equal electrode 13 orient to the equal electrode 13
  • the tendency of movement is strengthened, so that the substance to be guided by the electric field outside the organism can be introduced into the organism.
  • the neutral substance to be guided by the electric field refers to, for example, water in the body or water that needs to be introduced into the body.
  • the specific materials to be guided by the electric field that are sensitive to electric field forces such as certain specific ions, especially heavy metal ions or high-valent ions, such as Zr 4+ , Al 3+ , Fe 3+ , Cr 3+ , Ti 4+ , mercury
  • high-valent ions, high-valent ions of lead, high-valent ions of copper, high-valent ions of chromium, high-valent ions of arsenic, and high-valent ions of cadmium, such as heavy metal ions and high-valent metal ions that easily cause cancer are guided out of the organism , Completely change the local susceptible environment, so as to achieve the prevention and treatment of tumors.
  • the sensitivity to electric field force here means that it is easy to move under the action of electric field force.
  • the valence state of metal ions can be 2+ state, 3+ state, 4+ Any one of state or 6+ state, etc., not listed here;
  • the directional movement of the substance to be guided by the electric field outside the organism by the above electric field force can realize the introduction of ionic drugs, moisture, nutrients, skin care substances, etc. into the organism, so as to realize transdermal medication, water replenishment, nutritional supplementation or skin care.
  • the electret product 100 provided according to this embodiment can be used to guide materials to be guided by an electric field.
  • the material to be guided by the electric field can be used for one or more of the following:
  • Fig. 3 is a schematic side sectional view of the electret product involved in Example 2.
  • Example 4 is a schematic diagram of the use of the electret product involved in Example 2.
  • the holes 216 penetrating the electret product 200 can be distributed on the electret product 200.
  • the holes 216 can be single or multiple side by side. In this way, the arrangement of the holes 216 allows each A direct-acting electric field is formed between the two end faces 216a and 216b of each hole, so that it is easier for the substance to be guided by the electric field outside the organism to move into the body through the hole 216, or for the substance to be guided by the electric field in the organism to pass through The holes 216 move out of the organism. In this way, when the holes 216 are denser, the material to be guided by the electric field can be discharged from the part of the skin covered by the electret product 200 or into the organism as much as possible, thereby improving work efficiency.
  • the tumor as breast cancer as an example, it specifically illustrates how the electret product provided in Embodiment 1 or Embodiment 2 can be applied in the treatment of breast cancer.
  • the electret product made of electret material is a brassiere.
  • the brassiere can have holes 216 as in the second embodiment, preferably a plurality of holes 216, measured inside the brassiere Resident electric field, so that women wearing breasts can obtain long-term stability to prevent tumor electric field.
  • the specific preparation process is as follows:
  • PTFE membrane material is selected. This material is easy to electret and has stable chemical properties and is harmless to skin. And the material is soft and transparent, suitable for women to choose;
  • Electric field electret using 20 kV air corona discharge electric field, place the PTFE membrane on the positive electrode, flat, not bulging or uneven. Move the corona wire parallel to the top, and repeatedly electret the PTFE film in one direction. When electreting, the distance between the corona wire and the electret film should be strictly controlled to avoid the glow discharge burning the material, and basically keep 12 kV/ Centimeter spacing. After several times of uniform electret, the electret is successfully charged in about 10 minutes. Measured electret power is 3-4 kV;
  • Tailoring production chooses the splicing method to make a suitable bra according to the size of women.
  • the tailoring and sewing process pay special attention to the consistency of the electret material's electric field direction to keep the material dry. Avoid reversing the direction of the electric field to make the electric field effect poor.
  • the direction of the electric field of the material is always that all the negative electrodes face outwards and the positive electrodes face inwards.
  • the sewing thread uses non-conductor or semiconductor thread, and cannot use metal, carbon fiber and other threads to sew.
  • the finished industrial products can be formed as a whole at one time without stitching and sewing.
  • Different levels of residence voltage and electric field direction can be selected for different purposes. Because tumor cells are generally electronegative, for small-scale cancer cells that occasionally occur in the initial stage, the cells can be prevented from dividing and metastasis by changing the external electric field environment of the cells to prevent and treat cancer. In this case, the positive electrode is used to contact the skin. After sewing is completed, you can measure the potential on both sides of the inside and outside to confirm whether it is: 3-4 kV on the inside and the same potential difference with opposite polarity on the outside. If so, the electric field is established successfully.
  • this example is a harmless direction verified by experiments.
  • different voltage levels or electric field directions are selected.
  • the negative electrode contact of the electric field has not been tested, nor has it been tested to use different electric field directions for treatment after tumor metastasis.
  • the electric field has the possibility of a double-edged sword. It can inhibit the spread of cancer cells, correct the wrong direction and progress, and accelerate the spread of metastasis. So there is a risk to change the direction of the electric field.
  • Wear and use choose women with genetic or screening breast cancer trends, and wear electret electric bras. It can be worn for 24 hours. It is not recommended to wear it when bathing or exercising or sweating, to avoid short-circuiting the electrodes and causing the electric field to be invalid. After being wetted or washed, it needs to be dried before continuing to use. It is recommended to re-elect or replace with a new one after 4 years of use. Avoid the reduction of the effect caused by the weakened electric field. When wearing it, it is the same as normal clothing. You don’t need to be concerned about the existence of electric fields. Don’t touch the outer surface yourself, so as to avoid the accumulation of electric charges to form discharges on your body.
  • this bra can play a preventive role, mainly through the continuous stabilization of the electric field to inhibit tumor cells, avoid the mechanism of division and metastasis, and provide preventive treatment in the body.
  • the electric field is stable for a long time, heavy metal ions and high-valent ions that easily cause cancer will also be removed from the body by the electric field, completely changing the local susceptible environment. To achieve the goal of completely curing cancer.
  • one of the electric field two poles in contact with the skin is positive, and the other of the electric field two poles is negative.
  • the material to be guided by the electric field itself is charged, and the material to be guided by the electric field can be introduced into the organism. If the charge is positive or negative, choose the positive or negative pole of the other pole; in the same way, you can select the positive or negative pole of the electrode in contact with the skin according to whether the material to be guided by the electric field in the organism to be guided is positive or negative. ;
  • a neutral material to be guided by an electric field no matter the positive electrode or the negative electrode in contact with the skin, it can be charged by conduction of electric charge, so that it can be moved by electric field force. Because of the negative charge of tumors and the high-valent ions that have a greater impact on human tumors, generally in tumor treatment, the positive electrode is selected as the electrode that contacts the skin.
  • specific ions refer to heavy metal ions or high-valent ions.
  • specific ions can also refer to potassium, sodium, calcium, magnesium, mercury, lead, chromium, cadmium, etc., in addition to those mentioned in the above-mentioned embodiments.
  • Valence ions and other negative ions are examples of negative ions.
  • the electret products provided in the above embodiments in addition to the guidance of the charged substances in the embodiments, because the electret products of the present invention have two poles and can provide a stable, effective and durable electric field, they can also be used in other non-belt products.
  • the guidance of charged substances is only for all applications that require electric fields, such as influencing to overcome the barriers of the skin stratum corneum to improve transdermal medication, and to provide electric fields for tumor treatment.

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Abstract

本发明提供了一种能用于待电场引导物质引导、且能提供有效、持久安全电场的驻极体产品、其制备方法、使用方法及相关用途，其中的驻极体产品其特征在于，包括：用于电场驻极的驻极体材料，驻极体产品中形成有电场两极，并在该两极之间形成电场

Description

驻极体产品、其制备方法、使用方法及相关用途 技术领域
本发明涉及一种驻极体产品、其制备方法、使用方法及相关用途。
背景技术
电场治疗肿瘤技术是将电学应用于治疗恶性肿瘤的综合性课题。电场对肿瘤细胞的作用从提出到现在已经经历了近一个世纪，随着理论的日趋成熟，人们已经开始将电场应用于临床治疗肿瘤。目前国内外主要研究以下3种电场技术：直流电场、肿瘤治疗电场(tumor treating fields,即TT—Fields)、直流脉冲电场。
1、肿瘤治疗电场(tumor treating fields，TT—Fields)概述
交流电场已在疾病诊断、科研和环保等多个领域应用广泛。低于103z的低频率交流电场可以使细胞产生动作电位，因而被用来刺激神经或肌肉的生物电活动；高于106Hz的高频交流电场对一些细胞或组织产生热效应。介于10 3Hz和106Hz的中频交流电场则既不会导致去极化也不会较大的介电消耗，具有干扰细胞有丝分裂的作用。
1.1 TT—Fields抑制癌细胞分裂的机制
细胞内的一些带电分子(如蛋白、多肽和DNA等)，它们会随所处交流电场的变化而发生振荡。在匀场电场中，作用力会使带电分子的运动方向平行于电场方向。偶极子是阴极和阳极分离的分子，它的方向与电场方向保持一致。几乎所有带电分子，在不断变化的交流电场中均会朝着场强强的方向运动。处在有丝分裂末期的细胞，分裂沟分割成两个由狭窄细胞质连接的子细胞，在连接部位附近形成不均匀电场，极性分子朝着场强强的方向运动，从而影响有丝分裂。
(1)有丝分裂纺锤体形成的停止
纺锤体在有丝分裂中的作用是将姐妹染色单体平均分到两个子细胞中。在没有进行分裂的细胞中，微管亚单位会根据电场方向而平行排列。细胞进行有丝分裂的间期时，微管蛋白因受到合适强度的电场力而引起聚合障碍，使微管形成受阻。进而导致细胞发生碎裂。
(2)有丝分裂沟的破坏
所有有丝分裂的细胞都会发生纺锤体形成受阻的情况。有丝分裂后期的细胞，两个子染色体将被拉到细胞达的两极。在有丝分裂末期刚进行时，分裂沟最终形成，并将形成两个完全一样的细胞。而在这个狭窄的细胞膜连接处，将产生一个沙漏样非均匀电场。场强强度最大的位置是狭窄部位的中心位置，其中的场强将使带电粒子受到单向电场力的作用，使这些带电粒子向分裂沟方向发生移动。在TT—Fields也是利用此原理，使细胞内结构紊乱，产生细胞破坏作用。
1.2 TT—Fields的治疗特点
TT—Fields是将绝缘电极片放恶性肿瘤生长部位外周的皮肤来提供电场，电场装置平均每天工作18小时，形成两个相互垂直的强度在1-2V/cm之间、频率为200kHz的交流电场。可覆盖人体可能发病的几乎所有区域，且对非分化细胞无影响。据报道，TT—Fields治疗中，除了治疗设备中的电极贴片与皮肤接触可能导致局部皮炎外，尚未发现其他毒副作用。另外，有研究指出，TT—Fields毒性小且患者反应良好，配合治疗度高。
2 直流电场
直流电场治疗即电化学治疗，是将电极分别用作阴极和阳极插入肿瘤组织中，持续地通电，产生电解电离、电泳电渗等电化学反应，达到破坏或影响肿瘤细胞的目的。近年来，虽然已有众多科学家研究电化学治疗肿瘤的机制，但机理仍不十分明确，其最主要的原理可能为电化学处理后，电极周围组织的pH值发生显著变化，强制改变了肿瘤细胞及周围组织的pH值，在pH≤4或pH≥10的环境中，大部分酶蛋白失活变性，细胞膜的通透性改变，使肿瘤发生诸如如细胞核凝固、细胞膜崩溃、线粒体消失、核蛋白凝固坏死产等多种病理效应，最终导致癌细胞死亡。
3、脉冲电场
脉冲电场含有从低至高的多种频率，作用时间极短，所引起的生物学效应与直流电场或静电场存在很大区别，细胞在这种外加电场的作用下可以快速达到最大膜电压，细胞膜由于受到电场应力的作用会变薄，达到某一临界点时会被击穿产生电穿孔。当施加的瞬时脉冲电场强度大于1kV/cm时，细胞中分子的渗透率会大大提高；如果脉冲电场强度继续增加，细胞膜将发生不可逆性电穿孔。脉冲电场可以分为两大类，具体如下：
3.1 电脉冲化疗
电脉冲化疗(electric pulse chemotheraoy，EPCT)是一种将脉冲电场作用与化学药物相结合的肿瘤治疗方法。低强度的脉冲电场可以对细胞膜造成可逆性电穿孔，细胞膜通透性增大，内外分子交换增加，有利于局部给药发挥作用。细胞膜渗透程度取决于脉冲电场强度和持续时间、目标细胞的大小等。目前EPCT对皮肤或皮下等浅表部位肿瘤的治疗效果已得到肯定，而对深部肿瘤的治疗效果还没有相关的结果。
3.2 纳秒级脉冲电场
纳秒级脉冲电场(nanosecond pulsed electric fields，nsPEF)指脉宽在纳秒数量级的陡脉冲电场，陡脉冲电场能使肿瘤细胞膜发生不可逆性电穿孔。目前国内外对陡脉冲电场治疗肿瘤的研究已经取得了很大的进展，nsPEF技术为恶性肿瘤治疗提供了一种高效、无能量依赖性的工具。其抗肿瘤机制比较复杂，除了直接破坏肿瘤细胞外还能导致其凋亡，但nsPEF诱导肿瘤细胞凋亡的具体机制尚未完全明确。
以上各种电场，均需要电源装置提供电能，包括交流电、电池等。对于生物活体来说，不方便也不安全。
发明内容
本发明提供一种能用于待电场引导物质引导、且能提供有效、持久安全电场的驻极体产品、其制备方法、使用方法及相关用途。
为了实现上述目的，本发明采用了如下技术方案：
本发明的一个目的是提供一种驻极体产品，其特征在于，包括：
用于电场驻极的驻极体材料，驻极体产品中形成有电场两极，并在该两极之间形成电场。
于本发明的驻极体产品的一示例中：其中，两极分布在驻极体材料的相对的两个面。
于本发明的驻极体产品的一示例中：其中，通过电场驻极后在驻极体材料中形成有电场两极，并在该两极之间形成电场，再由驻极体材料制备得到驻极体产品。
于本发明的驻极体产品的一示例中：其中，电场电压为0.1-33000伏。
于本发明的驻极体产品的一示例中：其中，电场驻极采用高压驻极，和/或形成的电场为直流电场。
于本发明的驻极体产品的一示例中：其中，驻极体产品为面料。
于本发明的驻极体产品的一示例中：其中，面料用于制成医药贴片、穿戴物品、床上用品、用于制备服装所需的辅料、用于制备服装所需的粘合剂或用于制备服装所需的丝线中的一种或多种。
于本发明的驻极体产品的一示例中：其中，驻极体材料为驻极膜材料。
于本发明的驻极体产品的一示例中：其中，驻极膜材料为聚四氟乙烯膜材料、玻璃纤维膜材料或氧化铝膜材料等中的一种或多种。
本发明还提供一种驻极体产品的制备方法，其特征在于：通过电场驻极后在驻极体材料中形成有电场两极，并在该两极之间形成电场，再由驻极体材料制备得到驻极体产品，其中，驻极体产品为上述的驻极体产品。
于本发明的制备方法的一示例中：其中，电场驻极的过程如下：
使用20千伏空气电晕放电电场，将驻极体材料置于正电极上，平铺，不能鼓包或高低不平；在上方平行移动电晕线，单方向反复给驻极体材料驻极，驻极时需要严格控制电晕线与驻极体材料之间距离，避免辉光放电烧毁材料，基本保持12千伏/厘米间距。这样多次均匀驻极后，约10分钟左右，驻极带电成功，最终测得驻极电量为0.1-33000伏千伏。
于本发明的制备方法的一示例中：其中，由驻极体材料制备得到驻极体产品的过程中，应做到，驻极材料电场方向的一致性，保持材料干燥，避免电场方向颠倒。材料电场方向一致即所有负电极冲外，正电极朝里，完成后，可以测量所得驻极体产品内外两面的电位，确认是否是：内侧有0.1-33000伏电，且外侧有极性相反的同样电位差的电，如果有，电场建立成功。
本发明还提供一种驻极体产品的使用方法，其特征在于，包括：
步骤1，将驻极体产品的电场两极中的一极与生物体的皮肤接触；步骤2，通过皮肤电荷传导使得生物体内的组织成为电场两极中的一极的等电极；步骤3，通过电场力引导使得特定的待电场引导物质移动，其中，驻极体产品为上述的驻极体产品。
于本发明的使用方法的一示例中：其中，步骤3中，特定的待电场引导物质 位于生物体内，待电场引导物质为中性或带有与电场两极中的另一极相反的电荷，等电极与待电场引导物质之间电荷传导后，待电场引导物质带有与电场两极中的另一极相反的电荷而在电场力作用下向电场两极中的另一极移动。
于本发明的使用方法的一示例中，其特征在于：其中，待电场引导物质为水或对电场力敏感的特定的离子。
于本发明的使用方法的一示例中：其中，电场两极中的一极为正极，电场两极中的另一极为负极。
于本发明的使用方法的一示例中：其中，步骤3中，特定的待电场引导物质位于生物体外，待电场引导物质为中性或带有与等电极相反的电荷，电场两极中的另一极与待电场引导物质之间电荷传导后，待电场引导物质带有与等电极相反的电荷而在电场力作用下向等电极移动。
于本发明的使用方法的一示例中：其中，待电场引导物质为离子型药物或含水物质。
本发明还提供一种驻极材料在制备驻极体产品中的用途，其特征在于：驻极体产品为上述的驻极体产品。
于本发明的用途的一示例中：其中，驻极体产品用于待电场引导物质引导或肿瘤预防治疗中的一种或多种。
于本发明的用途的一示例中：其中，待电场引导物质为离子或水。
于本发明的用途的一示例中：待电场引导物质引导用于以下中的一种或多种：
(1)用于引导生物体水肿部位的水移动排出生物体外，实现消肿；
(2)用于引导离子型药物移动透皮进入生物体内，实现透皮给药；
(3)用于引导生物体内特定离子移动，预防和根除肿瘤。
于本发明的用途的一示例中：其中，在(3)中，特定离子为高价离子或重金属离子。
于本发明的用途的一示例中：其中，所述特定离子为Zr 4+、Al 3+、Fe 3+、Cr 3+、Ti 4+、汞的高价离子、铅的高价离子、铜的高价离子、铬的高价离子、砷的高价离子以及镉的高价离子中的一种或多种。
本发明还有一个目的是提供一种驻极体产品在待电场引导物质引导、肿瘤预防治疗或神经系统疾病治疗中的一种或多种用途，其特征在于：驻极体产品为上述的驻极体产品。于该用途的一示例中，所述待电场引导物质包括水、离子型药 物、含水物质、高价离子或重金属离子中的一种或多种；于该用途的一示例中，其中，所述特定离子为Zr 4+、Al 3+、Fe 3+、Cr 3+、Ti 4+、汞的高价离子、铅的高价离子、铜的高价离子、铬的高价离子、砷的高价离子以及镉的高价离子中的一种或多种。于该用途的一示例中，其中，对所述待电场引导物质的引导用于以下中的一种或多种：
(1)用于引导生物体水肿部位的水移动排出所述生物体外，实现消肿；
(2)用于引导离子型药物移动透皮进入生物体内，实现透皮给药；
(3)用于引导生物体内特定离子移动，预防和根除肿瘤。
根据本发明提供的驻极体产品、其制备方法、使用方法及相关用途，由于得到的驻极体产品包括用于驻极的驻极体材料，并在驻极体产品中形成有电场两极，并在该两极之间形成电场，从而在使用中，当电场两极中的一极与生物体的皮肤接触时能形成相应的等位电极，从而能让生物体和驻级材料另一极间形成电场，待电场引导物质带有电荷就能在电场力作用下趋向与其所带电荷相反的异极移动，从而能让生物体内的待电场引导物质被引导移动，或能让生物体外的待电场引导物质被导入生物体内，而且由于驻极体产品具有两极，使得驻极稳定，能有效长久保持电场，从而能代替有源电场，使得实际使用中更方便、安全、有效，并且由于驻极材料价格低廉，可以普及使用，无毒害，安全。
附图说明
图1为实施例1涉及的驻极体产品的一个侧面剖视示意图；
图2是实施例1涉及的的驻极体产品的使用示意图；
图3为实施例2涉及的驻极体产品的一个侧面剖视示意图；
图4是实施例2涉及的的驻极体产品的使用示意图。
具体实施方式
以下具体说明本发明的具体实施方式。
以下实施例中所使用的方法如无特殊说明，均为常规方法；所使用的材料、 试剂等，如无特殊说明，均可从商业途径获得。
电场力是，电场中带电荷物质能被异极吸引，同极排斥的作用力。电场力的大小取决于电场的电压与物质的带电荷量。
这里的异极即指电场两极(两个电极)中，与带电荷物质所带电荷相反的电极；同极即指电场两极中，与带电荷物质所带电荷相同的电极。
以下实施例中，带有电荷的待电场引导物质即为带电荷物质。
实施例1
以下实施例是为了对本发明涉及的驻极体产品、驻极材料制备其的用途、制备方法以及使用方法。
图1为实施例1涉及的驻极体产品的一个侧面剖视示意图。
如图1所示，本实施例提供的驻极体产品100，包括：用于电场驻极的驻极体材料10，也即驻极是让驻极体材料内部驻留电极，在材料中形成电场，从而也在驻极体产品100中形成有电场两极，也即电场两极中的一极11和电场两极中的另一极12，并在该两极之间形成电场，本实施例中，一极11为正极11和另一极12为负极12，该两极11和12分布在驻极体材料10的相对的两个面14和15。
本实施例中，通过电场驻极后在驻极体材料10中形成有电场两极11和12，并在该两极之间形成电场，再由驻极体材料10制备得到驻极体产品100。
另外，得到的电场电压(静电压)优先为0.1-33000伏。
另外，上述的电场驻极采用高压进行驻极，和/或形成的电场为直流电场。
本实施例中，驻极体产品100为面料，该面料可以用于制成医药贴片、穿戴物品、床上用品、用于制备服装所需的辅料、用于制备服装所需的粘合剂或用于制备服装所需的丝线中的一种或多种。穿戴物品可以是驻极电场服，也即驻极了电场的服装。
驻极电场服可以选自内衣或外衣。例如，内衣可以为乳罩。
在一种实施方式中，驻极体电场服包括：驻极体材料制成的驻极体材料面料，和将驻极体材料面料制成服装所需辅料、粘合剂、丝线。
驻极电场服可以在驻极之后制成，也可以现将驻极体材料面料驻极，再制成驻极电场服。
驻极电场服包括：驻极体材料制成的面料、内里。根据驻极材料的电场分布，做成和正常服装一样的贴片、内衣、外衣、床上用品，电场是分布在这些面料或里料的内外两面。靠近皮肤一面为正极，有效治疗电场是从负极到正极，由于电荷在体内传导，形成驻极面料外面负极和体内物质件(生物体内组织)的电场。能够测得电位为0.03伏-3000伏。
将电介质放在电场中就会被极化。许多电介质的极化是与外电场同时存在同时消失的。也有一些电介质，受强外电场作用后其极化现象不随外电场去除而完全消失，出现极化电荷“永久”存在于电介质表面和体内的现象。这种在强外电场等因素作用下，极化并能“永久”保持极化状态的电介质，称为驻极体，又叫永电体。驻极体材料即为存在这一特性的材料。优先地，本实施例中的驻极体材料为驻极膜材料，驻极膜材料又可以为聚四氟乙烯膜材料、玻璃纤维材料、氧化铝材料等，其中，聚四氟乙烯膜材料容易驻极，且化学性能稳定，皮肤接触无害、且材质柔软透明，适合于皮肤接触。
使用电晕放电的方法可以使聚四氟乙烯等驻极材料半永久带电，这个驻极所产生的静电电压会在0.1-33000伏；可以建立起有效的电场。由于材料晶格差异和纺织差异，电场形成后极性方向会有不同，错乱的电场方向会使驻极材料电场作用无序，不能产生有效电场作用，为此，选择驻极后，电场方向一致，同一电极统一在一个端面上或一个局部，这样电场就可以建立起来且不会消失。
根据建立起的电场方向和治疗部位，再将驻极后的驻极体材料制成医药贴片、穿戴物品、床上用品、用于制备服装所需的辅料、用于制备服装所需的粘合剂或用于制备服装所需的丝线中的一种或多种等驻极体产品，电场两极分别位于两个端面，也即相对的两面14和15。形成电场的正极、负极。在正负极间，形成静电场。将贴片靠近需要抑制部位。贴片产生持久安全的静电场，作用在生物体局部。
本实施例提供的驻极体产品100的制备方法：通过电场驻极后在驻极体材料中形成有电场两极11和12，并在该两极之间形成电场，再由驻极体材料制备得到驻极体产品。
电场驻极的过程如下：
使用20千伏空气电晕放电电场，将驻极体材料置于正电极上，平铺，不能鼓包或高低不平；
在上方平行移动电晕线，单方向反复给驻极体材料驻极，驻极时需要严格控制电晕线与驻极体材料之间距离，避免辉光放电烧毁材料，基本保持12千伏/厘米间距。这样多次均匀驻极后，约10分钟左右，驻极带电成功，最终测得驻极电量为0.1-33000伏千伏，优先地，可以为3-4千伏。
其中，由驻极体材料制备得到驻极体产品的过程中，应做到：
驻极材料电场方向的一致性，保持材料干燥，避免电场方向颠倒。材料电场方向一直即所有负电极冲外，正电极朝里；
若缝制，则缝制线使用非导体或半导体线，不能使用金属、碳纤等线缝制；制成工业品也可以采用整体一次成型，不用拼接缝制；
完成后，可以测量驻极体产品内外两面的电位，确认是否是：内侧有0.1-33000伏电，且外侧有极性相反的同样电位差的电，如果有，电场建立成功。
图2是实施例1涉及的的驻极体产品的使用示意图。
图2中示意了生物体的皮肤1(用虚线表示)，皮肤左侧表示生物体内组织，例如靠近皮肤1表皮的其他皮肤组织。
如图2所示，本实施例提供的驻极体产品100的使用方法，包括：
步骤1，将驻极体产品100的电场两极中的一极11与生物体的皮肤1接触，本实施例中将正极11与生物体的皮肤1接触；
步骤2，通过皮肤1将该一极11的电子传导给生物体内的组织使得该生物体内的组织成为一极11的等电极13，这样，相当于在等电极13和两极中的另一极12之间建立了电场，就本本实施例来说，也即这个电场是建立在生物体内的组织和面14之间；
步骤3，通过电场力引导使得特定的待电场引导物质定向移动，本实施例该另一极12即为负极12，根据使用需要，可以将特定的待电场引导物质分为位于生物体内或生物体外，位于生物体内即指待电场引导物质本身已经是生物体内的，位于生物体外即指待电场引导物质是未进入生物体内的。
对于位于生物体内的待电场引导物质，要在电场力下良好地定向移动，那么，该待电场引导物质需要为中性或带有与电场两极中的另一极12相反的电荷，这样，在等电极13与待电场引导物质之间进行电荷传导后：
当待电场引导物质为中性，则由于等电极13带有与另一极12相反的电荷，通过上述电荷传导，中性的待电场引导物质接受了来自等电极13的电荷而带上与另一极12相反的电荷，所以该待电场引导物质就能在电场力作用下向另一极12定向移动；
而当待电场引导物质带有与电场两极中的另一极12相反的电荷，具有在电场力作用下向另一极12定向移动的趋势，则同样地，通过上述电荷传导，此时的待电场引导物质接受了来自等电极13的电荷，使得其向另一极12定向移动的趋势加强。
同样地，对于位于生物体外的待电场引导物质，需要能良好地被导入生物体内，则该待电场引导物质为中性或带有与等电极13相反的电荷，这样，通过另一极12与待电场引导物质之间的电荷传导，能使得中性的待电场引导物质具有与等电极13相反的电荷，或能使得带有与等电极13相反的电荷的待电场引导物质向等电极13定向移动的趋势加强，从而，使得生物体外的待电场引导物质能被导入到生物体内。
上述中，中性的待电场引导物质例如指生物体内的水或需要导入生物体内的水。
通过电场力对生物体内的待电场引导物质的定向移动，通过对驻极的电场力大小的控制，可以：
将对电场力敏感的特定的待电场引导物质，例如某些特定离子，特别是重金属离子或高价离子，例如Zr 4+、Al 3+、Fe 3+、Cr 3+、Ti 4+、汞的高价离子、铅的高价离子、铜的高价离子、铬的高价离子、砷的高价离子以及镉的高价离子中的一种或多种等容易引发癌症的重金属离子以及高价金属离子被引导排出生物体，彻底改变局部易感环境，从而达到肿瘤的预防治疗，这里的对电场力敏感即指容易受电场力作用移动，上述中，金属离子的价态可以是2+态、3+态、4+态或6+态等中的任意一种，这里不一一列举；
也可以引导有助肿瘤细胞有丝分裂的带电荷的粒子、蛋白、极性物质等，这些对电场力敏感的特定的待电场引导物质受电场力的作用，从而影响肿瘤细胞增殖过程中的有丝分裂，从而达到抑制或破坏肿瘤细胞分裂增殖的效果，进而也达到肿瘤治疗；
也可以对局部水肿部位进行作用，将多余的水分排出生物体，实现消肿的作 用。
通过上述电场力对生物体外的待电场引导物质的定向移动，可以实现体外离子药物、水分、营养物质、护肤物质等导入到生物体内，从而实现透皮用药、补水、营养补充或护肤等。
可见，根据本实施例提供的驻极体产品100，可以用于待电场引导物质引导。具体地，如上，待电场引导物质引导可以用于以下中的一种或多种：
(4)用于引导生物体水肿部位的水移动排出生物体外，实现消肿；
(5)用于引导离子型药物移动透皮进入生物体内，实现透皮给药；
用于引导生物体内特定离子移动，预防和根除肿瘤。
实施例2
本实施例中，与实施例1中相同的部件采用相同的附图标记，省略与实施例1中相同的说明。
图3为实施例2涉及的驻极体产品的一个侧面剖视示意图。
图4是实施例2涉及的的驻极体产品的使用示意图。
如图3和图4所示，可以在驻极体产品200上分布贯穿驻极体产品200的孔216，孔216可以是单个，或多个并排，这样，通过孔216的设置，能让每个孔的两个端面216a和216b之间形成一个直接作用的电场，从而更容易让生物体外的待电场引导物质通过该孔216移动进入生物体内，或更容易让生物体内的待电场引导物质通过该孔216移动排出生物体外，这样，当孔216越密集，就越能让待电场引导物质尽量从驻极体产品200能覆盖到的皮肤部分排出或进入生物体内，提高工作效率。
比如，对于生物体内的水或高价离子等，当被等位电极13电传导后，在向另一极12移动中，容易被各个孔216另一端面216b的电荷引导而更容易排出生物体外；对于需要进入生物体内的离子型药物等，与另一极12接触导电后，通过孔216另一端面216a的电荷引导向等电极13移动，从而更容易透皮到生物体内。
实施例3
本实施例以肿瘤为乳腺癌为例，具体说明实施例1或实施例2提供的驻极体产品如何在乳腺癌的治疗中进行应用。
针对易发乳腺癌女性，使用的驻极体材料制成的驻极体产品为乳罩，该乳罩可以是如实施例2中的一样具有孔216，最好是多个孔216，在乳罩内测驻留电场，使佩戴女性乳房长期稳定获得预防肿瘤电场。具体制备过程如下：
材料选择，有很多驻极体材料可选择，本例选择聚四氟乙烯膜材料，这种材料容易驻极，且化学性能稳定，皮肤接触无害。且材质柔软透明，适合女性选择；
电场驻极，使用20千伏空气电晕放电电场，将聚四氟乙烯膜置于正电极上，平铺，不能鼓包或高低不平。在上方平行移动电晕线，单方向反复给聚四氟乙烯膜驻极，驻极时需要严格控制电晕线与驻极膜之间距离，避免辉光放电烧毁材料，基本保持12千伏/厘米间距。这样多次均匀驻极后，约10分钟左右，驻极带电成功。测得驻极电量为3-4千伏；
剪裁制作，本例选择拼接方式，根据女性尺码制作适合的乳罩，剪裁缝制过程特别注意驻极材料电场方向的一致性，保持材料干燥。避免电场方向颠倒，使电场效果差。材料电场方向一直即所有负电极冲外，正电极朝里。缝制线使用非导体或半导体线，不能使用金属、碳纤等线缝制。制成工业品可以采用整体一次成型，不用拼接缝制。
针对不同用途可以选择不同等级驻留电压和电场方向。由于肿瘤细胞一般为电负性，针对初期偶发小规模癌细胞，通过改变细胞外部电场环境，阻止其分裂和转移，达到预防治疗癌症目的，本例使用正极接触皮肤。缝制完成后，可以测量内外两面的电位，确认是否是：内侧有3-4千伏电，且外侧有极性相反的同样电位差的电，如果有，电场建立成功。
对于选择电场方向，本例是历经试验验证为无害方向。根据肿瘤形成个进程，选择不同电压等级或电场方向。本例未曾试验电场负极接触，也未曾试验在肿瘤转移进行起使用不同电场方向进行治疗。电场对于治疗癌症来说，存在双刃剑的可能性，既可以抑制癌细胞扩散，改错方向和进程，会加速转移扩散。所以进行电场方向改变存在风险。
穿戴使用，选择有遗传或筛查有乳腺癌趋势女性，佩戴使用驻极电场乳罩。可以24小时佩戴使用。不建议洗澡或运动出汗时佩戴，避免短路电极，造成电场无效。湿润或清洗后，需要晾干后继续使用。使用超过4年建议重新驻极或换新的。避免电场减弱造成效果下降。佩戴时和正常服装一样，不用可以在意电场存在，自己不要接触外表面，避免累计电荷对自体形成放电。
针对易发癌症人群，这个乳罩可以起预防作用，主要是通过电场持续稳定对肿瘤细胞抑制，避免分裂转移的机理，而对体内局部进行预防治疗。同时由于电场长期稳定存在，容易引发癌症的重金属离子以及高价离子，也会被电场作用而移出体内，彻底改变局部易感环境。达到彻底治愈癌症目的。
由于材料相对低廉，这种预防治疗手段可以普及，无毒害，安全。经济价值可观。本发明有效克服了现有技术中的种种缺点而具高度产业利用价值。
上述各个实施例仅例示性说明本发明的原理及其功效，而非用于限制本发明。任何熟悉此技术的人士皆可在不违背本发明的精神及范畴下，对上述实施例进行修饰或改变。因此，举凡所属技术领域中具有通常知识者在未脱离本发明所揭示的精神与技术思想下所完成的一切等效修饰或改变，仍应由本发明的权利要求所涵盖。
上述实施例中，与皮肤接触的电场两极中的一极为正极，电场两极中的另一极为负极，实际使用中，对于待电场引导物质本身带电荷，可以根据要导入生物体内的待电场引导物质带的正电荷还是负电荷，选择另一极为正极还是负极；同样地，可以根据要引导的生物体内的待电场引导物质带的是正电荷还是负电荷，相应选择与皮肤接触的一极为正极还是负极；对于中性的待电场引导物质，无论与皮肤接触的一极为正极还是负极都可以通过电荷传导使得其带电荷，从而能通过电场力实现移动。由于肿瘤的负电性，以及对人体肿瘤影响较大的大多为高价离子，所以一般在肿瘤治疗中，与皮肤接触的一极选为正极。
另外，上述实施例中，特定离子指重金属离子或高价离子，实际应用中，特定离子除了上述实施例所指，还可指钾、钠、钙、镁、汞、铅、铬、镉等的各价离子以及其他的负离子。
另外，上述实施例提供的驻极体产品，除了实施例中对带电荷物质的引导，由于本发明的驻极体产品具有两极，能提供稳定有效持久的电场，所以还可以用于其他非带电荷物质的引导，只是需要电场进行的一切应用，比如影响克服皮肤角质层阻碍提高透皮用药、提供提供肿瘤治疗需要的电场等方面。

Claims (28)

  1. 一种驻极体产品，其特征在于，包括：
    用于电场驻极的驻极体材料，
    所述驻极体产品中形成有电场两极，并在该两极之间形成电场。
  2. 根据权利要求1所述的驻极体产品，其特征在于：
    其中，所述两极分布在所述驻极体材料的相对的两个面。
  3. 根据权利要求1所述的驻极体产品，其特征在于：
    其中，通过电场驻极后在所述驻极体材料中形成有电场两极，并在该两极之间形成电场，再由所述驻极体材料制备得到所述驻极体产品。
  4. 根据权利要求1-3任意一项所述的驻极体产品，其特征在于：
    其中，所述电场电压为0.1-33000伏。
  5. 根据权利要求1-3任意一项所述的驻极体产品，其特征在于：
    其中，所述电场驻极采用高压驻极，和/或形成的所述电场为直流电场。
  6. 根据权利要求1-5任意一项所述的驻极体产品，其特征在于：
    其中，所述驻极体产品为面料。
  7. 根据权利要求6所述的驻极体产品，其特征在于：
    其中，所述面料用于制成医药贴片、穿戴物品、床上用品、用于制备服装所需的辅料、用于制备服装所需的粘合剂或用于制备服装所需的丝线中的一种或多种。
  8. 根据权利要求1-7中任意一项所述的驻极体产品，其特征在于：
    其中，所述驻极体材料为驻极膜材料。
  9. 根据权利要求8所述的驻极体产品，其特征在于：
    其中，所述驻极膜材料为聚四氟乙烯膜材料、玻璃纤维材料或 氧化铝材料中的一种或多种。
  10. 一种驻极体产品的制备方法，其特征在于：
    通过电场驻极后在驻极体材料中形成有电场两极，并在该两极之间形成电场，再由所述驻极体材料制备得到所述驻极体产品，
    其中，所述驻极体产品为权利要求1-9任意一项所述的驻极体产品。
  11. 根据权利要求10所述的制备方法，其特征在于：
    其中，所述电场驻极的过程如下：
    使用20千伏空气电晕放电电场，将驻极体材料置于正电极上，平铺，不能鼓包或高低不平；
    在上方平行移动电晕线，单方向反复给驻极体材料驻极，驻极时需要严格控制电晕线与驻极体材料之间距离，避免辉光放电烧毁材料，基本保持12千伏/厘米间距，这样多次均匀驻极后，约10分钟左右，驻极带电成功，最终测得驻极电量为0.1-33000伏千伏。
  12. 根据权利要求11所述的制备方法，其特征在于：
    其中，由所述驻极体材料制备得到所述驻极体产品的过程中，应做到：
    驻极材料电场方向的一致性，保持材料干燥，避免电场方向颠倒，材料电场方向一致即所有负电极冲外，正电极朝里，
    完成后，可以测量所得驻极体产品内外两面的电位，确认是否是：内侧有0.1-33000伏电，且外侧有极性相反的同样电位差的电，如果有，电场建立成功。
  13. 一种驻极体产品的使用方法，其特征在于，包括：
    步骤1，将所述驻极体产品的电场两极中的一极与生物体的皮肤接触；
    步骤2，通过皮肤电荷传导使得所述生物体内的组织成为所述电场两极中的一极的等电极；
    步骤3，通过电场力引导使得特定的待电场引导物质移动，
    其中，所述驻极体产品为权利要求1-9任意一项所述的驻极体产品。
  14. 根据权利要求13所述的使用方法，其特征在于：
    其中，步骤3中，特定的所述待电场引导物质位于所述生物体内，所述待电场引导物质为中性或带有与所述电场两极中的另一极相反的电荷，所述等电极与所述待电场引导物质之间电荷传导后，所述待电场引导物质带有与电场两极中的另一极相反的电荷而而在所述电场力作用下向所述电场两极中的另一极移动。
  15. 根据权利要求14所述的使用方法，其特征在于：
    其中，所述待电场引导物质为水或对电场力敏感的特定的离子。
  16. 根据权利要求15所述的使用方法，其特征在于：
    其中，所述电场两极中的一极为正极，所述电场两极中的另一极为负极。
  17. 根据权利要求13所述的使用方法，其特征在于：
    其中，步骤3中，特定的所述待电场引导物质位于所述生物体外，所述待电场引导物质为中性或带有与所述等电极相反的电荷，电场两极中的另一极与所述待电场引导物质之间电荷传导后，所述待电场引导物质带有与等电极相反的电荷而在所述电场力作用下向所述等电极移动。
  18. 根据权利要求17所得驻极体产品的使用方法，其特征在于：
    其中，所述待电场引导物质为离子型药物或含水物质。
  19. 一种驻极材料在制备驻极体产品中的用途，其特征在于：
    所述驻极体产品为权利要求1-9任意一项所述的驻极体产品。
  20. 根据权利要求19所述的用途，其特征在于：
    其中，所述驻极体产品用于待电场引导物质的引导或肿瘤预防治疗中的一种或多种。
  21. 根据权利要求20所述的用途，其特征在于：
    其中，所述待电场引导物质为离子或水。
  22. 根据权利要求21所述的用途，其特征在于：
    对所述待电场引导物质的引导用于以下中的一种或多种：
    (1)用于引导生物体水肿部位的水移动排出所述生物体外，实现消肿；
    (2)用于引导离子型药物移动透皮进入生物体内，实现透皮给药；
    (3)用于引导生物体内特定离子移动，预防和根除肿瘤。
  23. 根据权利要求22所述的用途，其特征在于：
    其中，在(3)中，所述特定离子为高价离子或重金属离子。
  24. 根据权利要求22所述的用途，其特征在于：
    其中，所述特定离子为Zr 4+、Al 3+、Fe 3+、Cr 3+、Ti 4+、汞的高价离子、铅的高价离子、铜的高价离子、铬的高价离子、砷的高价离子以及镉的高价离子中的一种或多种。
  25. 一种驻极体产品在待电场引导物质引导或肿瘤预防治疗中的一种或多种用途，其特征在于：
    所述驻极体产品为权利要求1-9任意一项所述的驻极体产品。
  26. 根据权利要求25所述的用途，其特征在于：
    其中，所述待电场引导物质包括水、离子型药物、含水物质、高价离子或重金属离子中的一种或多种。
  27. 根据权利要求26所述的用途，其特征在于：
    其中，所述特定离子为Zr 4+、Al 3+、Fe 3+、Cr 3+、Ti 4+、汞的高价离子、铅的高价离子、铜的高价离子、铬的高价离子、砷的高价离子以及镉的高价离子中的一种或多种。
  28. 根据权利要求25-27任意一项所述的用途，其特征在于：
    其中，对所述待电场引导物质的引导用于以下中的一种或多种：
    (1)用于引导生物体水肿部位的水移动排出所述生物体外，实现消肿；
    (2)用于引导离子型药物移动透皮进入生物体内，实现透皮给药；
    (3)用于引导生物体内特定离子移动，预防和根除肿瘤。
PCT/CN2020/094380 2019-06-04 2020-06-04 驻极体产品、其制备方法、使用方法及相关用途 WO2020244575A1 (zh)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101559255A (zh) * 2009-05-14 2009-10-21 北京中英联动技术服务有限公司 一种复合驻极体膜及其制备方法和用途
CN101905101A (zh) * 2010-07-30 2010-12-08 杭州电子科技大学 一种熔喷聚丙烯驻极体过滤材料的制备方法
CN202982936U (zh) * 2012-10-14 2013-06-12 徐国元 驻极体静电磁疗膜
CN104083628A (zh) * 2014-06-26 2014-10-08 张健新 一种化瘤攻癌止痛的药电理疗外用贴
WO2016118023A1 (en) * 2015-01-19 2016-07-28 TIKHOMIROV, Dmitry The method of functional biomimetic activation of an organism's vital functions

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CN101559255A (zh) * 2009-05-14 2009-10-21 北京中英联动技术服务有限公司 一种复合驻极体膜及其制备方法和用途
CN101905101A (zh) * 2010-07-30 2010-12-08 杭州电子科技大学 一种熔喷聚丙烯驻极体过滤材料的制备方法
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