WO2020228596A8 - 含氟取代咪唑盐类化合物、其制备方法、药用组合物及其应用 - Google Patents

含氟取代咪唑盐类化合物、其制备方法、药用组合物及其应用 Download PDF

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WO2020228596A8
WO2020228596A8 PCT/CN2020/089128 CN2020089128W WO2020228596A8 WO 2020228596 A8 WO2020228596 A8 WO 2020228596A8 CN 2020089128 W CN2020089128 W CN 2020089128W WO 2020228596 A8 WO2020228596 A8 WO 2020228596A8
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drug
preparation
pharmaceutical composition
preventing
method therefor
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PCT/CN2020/089128
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English (en)
French (fr)
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WO2020228596A1 (zh
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邓贤明
林圣彩
张宸崧
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厦门华绰生物医药科技有限公司
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Priority to KR1020217039481A priority Critical patent/KR102683706B1/ko
Priority to AU2020274362A priority patent/AU2020274362B2/en
Priority to US17/610,417 priority patent/US20220242828A1/en
Priority to JP2021543173A priority patent/JP2022532006A/ja
Priority to EP20806506.0A priority patent/EP3967683A4/en
Priority to CA3140417A priority patent/CA3140417A1/en
Priority to CN202080033678.3A priority patent/CN113966325B/zh
Publication of WO2020228596A1 publication Critical patent/WO2020228596A1/zh
Publication of WO2020228596A8 publication Critical patent/WO2020228596A8/zh

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/58—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/68—Halogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

提供了一类具有激活5'-腺苷一磷酸活化的蛋白激酶（AMPK）活性的化合物，其制备方法、包含该化合物的药物组合物，以及这些化合物在制备用于降低脂肪酸合成的药物、抑制甘油三酯和胆固醇合成的药物、预防和/或治疗肥胖以及II型糖尿病的药物、预防和/或治疗肿瘤的药物、预防和/或治疗帕金森症的药物、预防和/或治疗阿尔茨海默症的药物或者延长哺乳动物寿命的药物中的用途：
PCT/CN2020/089128 2019-05-10 2020-05-08 含氟取代咪唑盐类化合物、其制备方法、药用组合物及其应用 WO2020228596A1 (zh)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020217039481A KR102683706B1 (ko) 2019-05-10 2020-05-08 치환된 불소-함유 이미다졸 염 화합물, 이의 제조 방법, 이의 약학적 조성물 및 이의 용도
AU2020274362A AU2020274362B2 (en) 2019-05-10 2020-05-08 Substituted fluorine-containing imidazole salt compound, preparation method therefor, pharmaceutical composition thereof and use thereof
US17/610,417 US20220242828A1 (en) 2019-05-10 2020-05-08 Substituted fluorine-containing imidazole salt compound, preparation method therefor, pharmaceutical composition thereof and use thereof
JP2021543173A JP2022532006A (ja) 2019-05-10 2020-05-08 フッ素含有置換イミダゾール塩系化合物、その製造方法、医薬組成物及びその使用
EP20806506.0A EP3967683A4 (en) 2019-05-10 2020-05-08 SUBSTITUTED FLUORINE-CONTAINING IMIDAZOLE SALT COMPOUND, METHOD OF PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF
CA3140417A CA3140417A1 (en) 2019-05-10 2020-05-08 Substituted fluorine-containing imidazole salt compound, preparation method therefor, pharmaceutical composition thereof and use thereof
CN202080033678.3A CN113966325B (zh) 2019-05-10 2020-05-08 含氟取代咪唑盐类化合物、其制备方法、药用组合物及其应用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910387619.5 2019-05-10
CN201910387619.5A CN111909092A (zh) 2019-05-10 2019-05-10 含氟取代咪唑盐类化合物、其制备方法、药用组合物及其应用

Publications (2)

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WO2020228596A1 WO2020228596A1 (zh) 2020-11-19
WO2020228596A8 true WO2020228596A8 (zh) 2021-12-16

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PCT/CN2020/089128 WO2020228596A1 (zh) 2019-05-10 2020-05-08 含氟取代咪唑盐类化合物、其制备方法、药用组合物及其应用

Country Status (9)

Country Link
US (1) US20220242828A1 (zh)
EP (1) EP3967683A4 (zh)
JP (1) JP2022532006A (zh)
KR (1) KR102683706B1 (zh)
CN (2) CN111909092A (zh)
AU (1) AU2020274362B2 (zh)
CA (1) CA3140417A1 (zh)
TW (1) TWI845673B (zh)
WO (1) WO2020228596A1 (zh)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009096905A1 (en) * 2008-01-30 2009-08-06 Agency For Science, Technology And Research Method for treating fibrosis and cancer with imidazolium and imidazolinium compounds
WO2009109798A2 (en) * 2008-03-07 2009-09-11 Universität Ulm Precursors of lipid metabolism for the diagnosis and treatment of cancer
WO2009146146A2 (en) * 2008-04-04 2009-12-03 Hsiao Benjamin S Novel ionic liquids, functionalized particulates, and fluoropolymer composites
JP2009286780A (ja) * 2008-04-30 2009-12-10 Ishihara Sangyo Kaisha Ltd １，２，３−置換イミダゾリウム塩を有効成分として含有する農園芸用殺菌剤
CA2833886A1 (en) * 2011-04-29 2012-11-01 The University Of Akron Azolium and purinium salt anticancer and antimicrobial agents
CN108689939A (zh) * 2017-04-07 2018-10-23 厦门华绰生物医药科技有限公司 取代咪唑盐类化合物、其制备方法、药用组合物及其应用

Also Published As

Publication number Publication date
KR102683706B1 (ko) 2024-07-11
CA3140417A1 (en) 2020-11-19
AU2020274362A1 (en) 2021-12-23
TW202104192A (zh) 2021-02-01
TWI845673B (zh) 2024-06-21
EP3967683A4 (en) 2023-05-31
EP3967683A1 (en) 2022-03-16
CN111909092A (zh) 2020-11-10
AU2020274362B2 (en) 2023-07-13
US20220242828A1 (en) 2022-08-04
WO2020228596A1 (zh) 2020-11-19
CN113966325A (zh) 2022-01-21
JP2022532006A (ja) 2022-07-13
CN113966325B (zh) 2023-10-03
KR20220004730A (ko) 2022-01-11

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