WO2020212159A1 - Produit de soin buccal - Google Patents

Produit de soin buccal Download PDF

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Publication number
WO2020212159A1
WO2020212159A1 PCT/EP2020/059455 EP2020059455W WO2020212159A1 WO 2020212159 A1 WO2020212159 A1 WO 2020212159A1 EP 2020059455 W EP2020059455 W EP 2020059455W WO 2020212159 A1 WO2020212159 A1 WO 2020212159A1
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WO
WIPO (PCT)
Prior art keywords
composition
calcium
product
source
phosphate
Prior art date
Application number
PCT/EP2020/059455
Other languages
English (en)
Inventor
Alison Katharine Green
Andrew Joiner
Adam John Limer
Gareth Jon OWENS
Original Assignee
Unilever Plc
Unilever N.V.
Conopco, Inc., D/B/A Unilever
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Plc, Unilever N.V., Conopco, Inc., D/B/A Unilever filed Critical Unilever Plc
Publication of WO2020212159A1 publication Critical patent/WO2020212159A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0216—Solid or semisolid forms
    • A61K8/0233—Distinct layers, e.g. core/shell sticks
    • A61K8/0237—Striped compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86—Polyethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/30—Characterized by the absence of a particular group of ingredients
    • A61K2800/31—Anhydrous

Definitions

  • the present invention relates to an oral care product that can back fill lesions in the teeth.
  • Tooth decay, or caries occurs upon the enamel of the teeth and causing lesions within the teeth.
  • Fluoride commonly used in toothpaste compositions helps prevent this dental erosion. As fluoride is extremely reactive it is thought to react with the hydroxy apatite of the enamel at the surface of the tooth. This tends to yield a hardening of the surface layer but very little remineralisation occurs at depth without penetrating the lesion.
  • the present invention relates to a product comprising a calcium source that is insoluble or slightly soluble in water and a phosphate source, for use in a treatment to backfill tooth lesions.
  • the invention further relates to the use of a product comprising a calcium source that is insoluble or slightly soluble in water and a phosphate source, for use in a treatment to backfill tooth lesions.
  • backfill refers to deeper penetration of an enamel regeneration/replacement agent into a lesion of a tooth.
  • the oral care product of the invention comprises a phosphate source.
  • the phosphate source that may be used in this invention is limited only to the extent that the same may be used in a composition suitable for use in an oral cavity.
  • a sodium phosphate is preferred for use in this invention especially monosodium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium pyrophosphate, tetrasodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate.
  • the phosphate source is preferably one which is water soluble.
  • the phosphate source makes up from 0.5 to 15%, and preferably, from 1 to 12%, and most preferably, from 2 to 9% by weight of the composition, based on total weight of the composition in which it is included and including all ranges subsumed therein.
  • the phosphate source used is one which results in an oral care composition having a pH from 5.5 to 10.5, preferably from 6.5 to 10, and most preferably, about 8 to 9.5.
  • the phosphate source used is trisodium phosphate and monosodium dihydrogen phosphate at a trisodium phosphate to monosodium dihydrogen phosphate weight ratio of 1 :4 to 4: 1 , preferably 1 :3 to 3:1 , and most preferably, from 1 :2 to 2: 1 , including all ratios subsumed therein.
  • the product of the invention comprises a calcium source that is insoluble or slightly soluble in water.
  • Soluble means a source that dissolves in water to give a solution with a concentration of at least 0.1 moles per litre at room temperature.
  • Insoluble means a source that dissolves in water to give a solution with a concentration of less than 0.001 moles per litre at room temperature.
  • Slightly soluble therefore, is defined to mean a source that dissolves in water to give a solution with a concentration of greater than 0.001 moles per litre at room temperature and less than 0.1 moles per litre at room temperature.
  • Substantially free of, as used herein, means less than 1.5%, and preferably, less than 1.0%, and most preferably, from 0.0 to 0.75% by weight, based on total weight of the oral care composition, including all ranges subsumed therein.
  • the calcium source suitable for use in this invention is limited only to the extent that the same may be used in an oral cavity. In a preferred embodiment, the calcium source employed is insoluble or slightly soluble in water, but most preferably, insoluble in water
  • Illustrative examples of the types of calcium source that may be used in this invention include, for example, calcium phosphate (i.e., added), calcium gluconate, calcium oxide, calcium lactate, calcium carbonate, calcium hydroxide, calcium sulfate, calcium carboxymethyl cellulose, calcium alginate, calcium salts of citric acid, calcium silicate, mixtures thereof or the like.
  • the calcium source is calcium silicate.
  • the calcium silicate used is (CaSOs) whereby the same is made commercially available under the name Microcal ET by Ineos Silicas, Ltd.
  • the calcium source is insoluble calcium silicate, present as the composite material calcium oxide-silica (CaO-SiC>2) as described in commonly-owned application Publication No. 2008/015117.
  • the ratio of calcium to silicon may be from 1 : 10 to 3: 1.
  • the Ca:Si ratio is preferably from 1 :5 to 2: 1 , and more preferably, from 1 :3 to 2: 1 , and most preferably, from about 1 :2 to 2: 1.
  • the calcium silicate may comprise mono-calcium silicate, bi-calcium silicate, or tri-calcium silicate whereby ratios of calcium to silicon (Ca:Si) should be understood to be atom ratios.
  • the calcium source employed in this invention may be in a crystalline or amorphous state, and preferably, the same is in an amorphous state.
  • the calcium source is in a mesoporous state, i.e. the source is a material having pores with diameters from 1 nm to 50 microns.
  • Mesoporous calcium silicate (MCS) is often preferred.
  • the MCS which may be used in this invention can be made by combining a calcium salt, a silica precursor like silicate and a structure-directing agent to yield a solid suitable for calcinating.
  • a structure-directing agent to yield a solid suitable for calcinating.
  • the amount of calcium source in the composition is typically from 0.1 to 50%, and preferably, from 1 to 30%, and most preferably, from 5 to 20% by weight of the oral care composition based on total weight of the oral care composition and including all ranges subsumed therein.
  • An alternative form of calcium silicate is calcium silicate coated T ⁇ 2.
  • Examples of preferred forms of coated calcium silicate for this alternative are disclosed in WO2012/031786 and
  • the product comprises two compositions or phases, the first composition or phase comprising the calcium source and the second composition or phase comprising the phosphate source.
  • the composition is a toothpaste
  • the toothpaste comprises an anhydrous base formulation in that the base comprises less than 1wt% of the composition of water; preferably less than 0.5 wt%, more preferably less than 0.1 wt% of the total composition.
  • the composition of the invention especially if a toothpaste comprises from 20 to 90wt% (by weight by based on the total weight of the composition) of one or more organic polyols having 3 or more hydroxyl groups in the molecule.
  • organic polyols having 3 or more hydroxyl groups in the molecule include glycerol, sorbitol, xylitol, mannitol, lactitol, maltitol, erythritol, and hydrogenated partially hydrolyzed polysaccharides.
  • the most preferred organic polyol is glycerol. Mixtures of any of the above described materials may also be used.
  • composition of the invention is most preferably organic polyol-based.
  • organic polyol-based generally means that the composition is not oil- based or water-based, but instead organic polyol (as defined above) forms a liquid continuous phase in which the particulate ingredients of the composition (such as the one or more particulate abrasive cleaning agents) are dispersed.
  • composition of the invention is glycerol-based.
  • the amount of organic polyol in the composition of the invention suitably ranges from 35 to 90wt%, preferably from 45 to 80wt% (by total weight organic polyol based on the total weight of the composition). More preferably the composition contains from 60 to 75wt% glycerol based on the total weight of the composition.
  • compositions of the invention especially if a toothpaste, preferably comprises a particulate abrasive cleaning agent in an amount of from 3 to 75wt% (by weight based on the total weight of the oral care composition).
  • Suitable particulate abrasive cleaning agents include abrasive silicas, calcium carbonate, dicalcium phosphate, tricalcium phosphate, calcined alumina, sodium and potassium metaphosphate, sodium and potassium pyrophosphates, sodium tri metaphosphate, sodium hexametaphosphate, particulate hydroxyapatite and mixtures thereof.
  • Preferred particulate abrasive cleaning agents for use in the invention are selected from abrasive silicas such as silica xerogels, hydrogels and aerogels and precipitated particulate silicas and mixtures thereof.
  • compositions of the invention especially if a toothpaste, comprises one or more surfactants in an amount of from 0.2 to 5wt% (by weight based on the total weight of the oral care composition)
  • Suitable surfactants include anionic surfactants, such as the sodium, magnesium, ammonium or ethanolamine salts of Cs to Cis alkyl sulphates (for example sodium lauryl sulphate), Cs to Cis alkyl sulphosuccinates (for example dioctyl sodium sulphosuccinate), Csto Cis alkyl sulphoacetates (such as sodium lauryl sulphoacetate), Cs to Cis alkyl sarcosinates (such as sodium lauryl sarcosinate), Cs to Cis alkyl phosphates (which can optionally comprise up to 10 ethylene oxide and/or propylene oxide units) and sulphated monoglycerides.
  • anionic surfactants such as the sodium, magnesium, ammonium
  • Suitable surfactants include nonionic surfactants, such as optionally polyethoxylated fatty acid sorbitan esters, ethoxylated fatty acids, esters of polyethylene glycol, ethoxylates of fatty acid monoglycerides and diglycerides, and ethylene oxide/propylene oxide block polymers.
  • suitable surfactants include amphoteric surfactants, such as betaines or sulphobetaines.
  • Preferred surfactants for use in the invention are selected from sodium lauryl sulfate, sodium lauryl sulfoacetate, cocamidopropyl betaine, sodium alpha olefin sulfonate, dioctyl sodium sulfosuccinate, sodium dodecyl benzene sulfonate and mixtures thereof.
  • the liquid continuous phase of the composition is structured with crystals of one or more solid polyethylene glycols having a melting point of 25°C or above.
  • the melting point ranges from 35 to 65°C, more preferably from 55 to 60° C.
  • the crystals of the solid polyethylene glycol(s) help to provide an optimised microstructure for the composition.
  • Polyethylene glycols have the general formula H(OCH2CH2)n OH, where n is the number of repeating oxyethylene units.
  • Commercially available polyethylene glycols are usually not uniform chemical compounds, but instead consist of a distribution of similar polymer members of the homologous polyethylene glycol series, defined by average values of n and molecular weight.
  • the melting point 5 generally increases with increasing average values of n and molecular weight.
  • Suitable solid polyethylene glycols have an average value of n in the above general formula ranging from about 20 to 220, preferably from about 40 to 150, more preferably from about 32 to 90, most preferably from about 60 to 75.
  • the average molecular weight suitably ranges from about 950 to 11 ,250, preferably 10 from about 1800 to 6600, more preferably from about 1400 to 4400, most preferably from about 2700 to 3700 g/mol.
  • Suitable commercially available materials include for example Polyglykol® 3000 (ex Clariant). Mixtures of any of the above described materials may also be used.
  • the amount of solid polyethylene glycol (as defined above) in compositions of the invention suitably ranges from 0.1 to 5%, preferably from 0.5 to 3%, more preferably from 1 to 2.5% by total weight solid polyethylene glycol (as defined above) based on the total weight of the composition.
  • the liquid continuous phase of the composition of a toothpaste composition in particular of non- aqueous compositions may comprises one or more liquid polyethylene glycols having a melting point below 25°C.
  • the melting point ranges from -50 to 22°C, more preferably from -15 to 8° C, most preferably 25 from 4 to 8°C.
  • the liquid polyethylene glycol(s) helps to make processing of the composition easier, especially at high shear, by reducing the overall viscosity of the liquid continuous phase 30.
  • Preferred liquid polyethylene glycols have an average value of n in the general formula
  • H(OCH2CH2)n OH (as described above) ranging from about 4 to 12, more preferably about 6 to 8, most preferably about 8.
  • the average molecular weight suitably ranges from about 190 to 630, more preferably from about 285 to 420, 5 most preferably from about 380 to 420 g/mol.
  • Suitable commercially available materials include for example PEG 400 (ex BDH Chemicals). Mixtures of any of the above described materials may also be used.
  • the amount of liquid polyethylene glycol (as defined above) in compositions of the 10 invention suitably ranges from 1 to 20%, preferably from 5 to 15%, more preferably from 8 to 12% by total weight liquid polyethylene glycol (as defined above) based on the total weight of the composition.
  • composition of the invention especially if a toothpaste, may comprises xanthan gum in an amount of from 0.01 to 5wt% (by weight based on the total weight of the oral care composition).
  • Xanthan gum is a fermentation product prepared by action of the bacteria of the genus
  • Xanthomonas upon carbohydrates Four species of Xanthomonas, namely X.campestris, X. phaseoli, Xmalvoceamm and X.carotae are reported in the literature to be the most efficient gum producers.
  • Xanthan gum is available from several commercial suppliers such a RT Vanderbilt Company and CP Kelco. Examples of suitable xanthan gums are Keltrol®, Keltrol® F, Keltrol® T, Keltrol® TF, Xantural® 180 and Vanzan® NF.
  • the amount of xanthan gum in the composition of the invention preferably ranges from 0.05 to 1 5wt%, more preferably from 0.1 to 0.9wt% (by weight based on the total weight of the oral care composition).
  • polymeric thickening agents may be used in the composition of the invention.
  • additional polymeric thickening agents may be of natural or synthetic origin, with a molecular weight typically ranging from 1 ,000 up to about 5,000,000.
  • materials include carboxyvinyl polymers (such as polyacrylic acids cross-linked with polyallyl sucrose or polyallyl pentaerythritol), hydroxyalkyl cellulose derivatives (such as hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxyethylpropyl cellulose,
  • hydroxybutylmethyl cellulose and hydroxypropylmethyl cellulose water soluble salts of cellulose ethers (such as sodium carboxymethyl cellulose and sodium carboxymethyl hydroxyethyl cellulose, polyvinylpyrrolidone, polyethylene glycols, and mixtures thereof.
  • the oral care product described herein may comprise ingredients which are common in the art, such as:
  • ⁇ antimicrobial agents e.g. Triclosan, chlorhexidine, copper-, zinc- and stannous salts such as zinc citrate, zinc sulphate, zinc glycinate, sodium zinc citrate and stannous pyrophosphate, sanguinarine extract, metronidazole, quaternary ammonium compounds, such as cetylpyridinium chloride; bis-guanides, such as chlorhexidine digluconate, hexetidine, octenidine, alexidine; and halogenated bisphenolic compounds such as 2,2’ methylenebis-(4- chloro-6-bromophenol) ;
  • ⁇ anti-inflammatory agents such as ibuprofen, flurbiprofen, aspirin, indomethacin, etc.;
  • ⁇ anti-caries agents such as sodium trimetaphosphate and casein;
  • plaque buffers such as urea, calcium lactate, calcium glycerophosphate and polyacrylates
  • vitamins such as Vitamins A, C and E;
  • ⁇ desensitizing agents e.g. potassium citrate, potassium chloride, potassium tartrate,
  • potassium bicarbonate, potassium oxalate, and potassium nitrate potassium bicarbonate, potassium oxalate, and potassium nitrate
  • ⁇ anti-calculus agents e.g. alkali-metal pyrophosphates, hypophosphite-containing polymers, organic phosphonates and phosphocitrates, etc;
  • biomolecules e.g. bacteriocins, antibodies, enzymes, etc ;
  • ⁇ flavors e.g., peppermint and spearmint oils
  • ⁇ proteinaceous materials such as collagen
  • ⁇ coloring agents like FD&C blue, yellow and/or red dyes/colorants
  • ⁇ surfactants such as anionic, cationic and zwitterionic or amphoteric surfactants (e.g., sodium lauryl sulfate, sodium dodecylbenzene sulfonate);
  • ⁇ particulate abrasive materials such as abrasive silicas, aluminas, calcium carbonates,
  • zirconium silicate polymethylmethacrylate, dicalciumphosphates, calcium pyrophosphates, hydroxyapatites, trimetaphosphates, insoluble hexametaphosphates as well as
  • ⁇ fluoride sources like sodium fluoride, stannous fluoride, sodium monofluorophosphate, zinc ammonium fluoride, tin ammonium fluoride, calcium fluoride, cobalt ammonium fluoride or mixtures thereof;
  • antimicrobial agents can also be included.
  • examples of such polymers are copolymers of polyvinylmethylether with maleic anhydride and other similar delivery enhancing polymers, e.g., those described in DE-A03,942,643; buffers and salts to buffer the pH and ionic strength of the oral care compositions; and
  • bleaching agents such as peroxy compound, e.g., potassium peroxydiphosphate, effervescing systems such as sodium bicarbonate/citric acid systems, color change systems, and the like.
  • Such ingredients common in the art typically and collectively make-up less than 20% by weight of the oral care composition, and preferably, from 0.0 to 15% by weight, and most preferably, from about 0.01 to about 12% by weight of the oral care composition, including all ranges subsumed therein.
  • the composition is in the form of an extrudable semi-solid such as a cream, paste or gel (or mixture thereof).
  • composition may be in the form of a mask, a layered strip that is applied to the teeth.
  • the mask has an elongate shape of a length sufficient that when placed against the front surface of a user’s teeth it extends across a plurality of teeth, and of sufficient width that it extends at least from the gumline of the teeth to the crowns of the teeth.
  • the strip/device has the enamel regeneration system deposited upon the strip surface thereof as a layer or more preferably multiple layers.
  • An alternative embodiment of the invention is in the form of a serum.
  • a serum is a liquid or gel product that is applied to the teeth and not rinsed off.
  • sustained contact means the product is left on the teeth for 1 to 60 minutes, preferably, about 5 to 45 minutes, more preferably 10 to 30 minutes before being removed.
  • the application of the oral care product of the invention is carried out once daily for a period of several consecutive days, in addition to a regular regime of tooth brushing (preferably at least twice daily).
  • the toothpaste should be used at least twice a day to clean the teeth, preferably the cleaning period is at least 3 minutes, preferably 5 minutes.
  • Examples A and B were prepared by adding 80% of the water, sorbitol, polyethylene glycol, sodium saccharine, sodium fluoride and titanium dioxide to the mixer. The raw materials were mixed under vacuum for 10 minutes before adding thickening silica and sodium carboxymethyl cellulose and mixed for a further 10 minutes. Abrasive silica was added and mixed under vacuum for a further 10 minutes. Sodium lauryl sulfate was dissolved in the remaining water and added to the mixer.
  • flavour was added the paste mixed under vacuum for a further 10 minutes.
  • Example 1 was prepared by first heating the glycerol and the PEG-8 to 60 degrees centigrade and disperse the PEG-60. Subsequently the trisodium phosphate, monosodium dihydrogen phosphate, sodium monofluorophosphate and sodium saccharin were added and mixed until lump free, keeping the temperature at 60 degrees C. The calcium silicate is then added slowly into the mixture and mixed for 10 minutes. The sodium lauryl sulphate and abrasive silica, are added to the mixture and mixed for 10 minutes. The polyacrylic acid polymer is added and mixed for 5 minutes. Finally, the mixture is cooled to 30 degrees centigrade and the flavour is added and mixed to disperse.
  • An in-vitro assay was conducted to asses the in-vitro caries repair potential.
  • the enzyme used was 10 KU of bovine serum alkali phosphatase. This a stock solution was created using appropriate dilutions in deionised water. An aliquot of the enzyme slock solution was added to the toothpaste slurry immediately before cycling to give a final concentration of 1 U.mL 1 alkali phosphatase in the toothpaste slurry.
  • the composition of Buffer A was 50 mM acetic acid, 2.25 mM CaCI 2 , 1.35 mM KH 2 PO 4 , 130 mM KCI, adjusted to pH 5.0 with NaOH.
  • the composition of Buffer B was 20 mM HEPES, 2.25 mM CaCI 2 , 1.35 mM KH 2 P0 4 , 130 mM KCL, adjusted to pH 7.0 with NaOH.
  • Two thin (approximately 150 pm) sections were taken from both the baseline and the treated lesions areas within 2 mm of each other. Sections were polished between glass plates with 0.9 pm AI203 slurry ensuring their thickness remained constant 80 pm. Thin sections were mounted on acetate sample frames and the frame placed on x-ray sensitive film plates. The assembly was radiographed at 20 kV and 20 mA using a Cu(Ka) radiation source operating at a distance of 22.1 cm along with an 11-piece aluminium step wedge for 12 min. The film was developed, and a window representative of the entire lesion area selected for analysis by transverse
  • TMR microradiography
  • Mineral volume was calculated as a function of depth from the enamel surface. Baseline values were subtracted from the post-treatment values to obtain mineral depth profiles and volume for each individual sample.
  • Figure 1 is a graph illustrating the effect of the toothpastes of the Examples on tooth lesions.
  • Figure I represents the volume of post treatment lesions subtracted from the volume of baseline lesions for each treatment group. The lesions are divided into three zones.
  • Zone A Outer Enamel
  • Zone B Middle Layer
  • Zone C Inner Enamel

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Inorganic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne un produit comprenant une source de calcium qui est insoluble ou légèrement soluble dans l'eau et une source de phosphate, destiné à être utilisé dans un traitement pour le remblayage de lésions dentaires.
PCT/EP2020/059455 2019-04-17 2020-04-02 Produit de soin buccal WO2020212159A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19169800 2019-04-17
EP19169800.0 2019-04-17

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WO2020212159A1 true WO2020212159A1 (fr) 2020-10-22

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Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1468149A (en) * 1974-02-26 1977-03-23 Nat Res Dev Tooth remineralising composition
DE3942643A1 (de) 1988-12-29 1990-07-05 Colgate Palmolive Co Mundpflegemittel
RU2292868C1 (ru) * 2005-05-06 2007-02-10 Институт физико-химических проблем керамических материалов РАН Материал для заполнения костных челюстно-лицевых и стоматологических дефектов
WO2008015117A2 (fr) 2006-08-01 2008-02-07 Unilever Plc Biomatériaux, leur préparation et leur utilisation
WO2008068149A1 (fr) * 2006-12-05 2008-06-12 Unilever Plc Produit de soin buccal
WO2010054494A2 (fr) * 2008-11-14 2010-05-20 Profimed S.R.O. Composition de soin buccal biomimétique
WO2012031786A2 (fr) 2010-09-10 2012-03-15 Unilever Plc Compositions de soins buccaux avantageuses pour les dents
WO2012031785A2 (fr) 2010-09-10 2012-03-15 Unilever Plc Particules composites actives et leur procédé de production
WO2013095366A1 (fr) * 2011-12-20 2013-06-27 Colgate-Palmolive Company Compositions d'hygiène orale
WO2016131745A1 (fr) * 2015-02-16 2016-08-25 Unilever Plc Composition d'hygiène bucco-dentaire
WO2016192923A1 (fr) * 2015-06-05 2016-12-08 Unilever Plc Dispositif de soins bucco-dentaires

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1468149A (en) * 1974-02-26 1977-03-23 Nat Res Dev Tooth remineralising composition
DE3942643A1 (de) 1988-12-29 1990-07-05 Colgate Palmolive Co Mundpflegemittel
RU2292868C1 (ru) * 2005-05-06 2007-02-10 Институт физико-химических проблем керамических материалов РАН Материал для заполнения костных челюстно-лицевых и стоматологических дефектов
WO2008015117A2 (fr) 2006-08-01 2008-02-07 Unilever Plc Biomatériaux, leur préparation et leur utilisation
WO2008068149A1 (fr) * 2006-12-05 2008-06-12 Unilever Plc Produit de soin buccal
WO2010054494A2 (fr) * 2008-11-14 2010-05-20 Profimed S.R.O. Composition de soin buccal biomimétique
WO2012031786A2 (fr) 2010-09-10 2012-03-15 Unilever Plc Compositions de soins buccaux avantageuses pour les dents
WO2012031785A2 (fr) 2010-09-10 2012-03-15 Unilever Plc Particules composites actives et leur procédé de production
WO2013095366A1 (fr) * 2011-12-20 2013-06-27 Colgate-Palmolive Company Compositions d'hygiène orale
WO2016131745A1 (fr) * 2015-02-16 2016-08-25 Unilever Plc Composition d'hygiène bucco-dentaire
WO2016192923A1 (fr) * 2015-06-05 2016-12-08 Unilever Plc Dispositif de soins bucco-dentaires

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