WO2020202320A1 - Decomposition catalyst for hydrogen peroxide for disinfecting contact lenses, and method for manufacturing decomposition catalyst - Google Patents

Abstract

The present invention provides a decomposition catalyst for hydrogen peroxide for disinfecting contact lenses, the decomposition catalyst having excellent durability. This catalyst is a decomposition catalyst for hydrogen peroxide for disinfecting contact lenses, the decomposition catalyst containing a carrier and platinum-containing microparticles fixed onto the carrier, wherein: the carrier has a substrate and a coating layer provided on the surface of the base; and the coating layer includes a polymer that includes repeating units having an aromatic ring substituted by two or more hydroxyl groups, and a heteroatom having a lone electron pair.

Description

Decomposition catalyst of hydrogen peroxide for contact lens disinfection and its manufacturing method

The present invention relates to a catalyst for decomposing hydrogen peroxide for disinfecting contact lenses, a method for producing the same, and the like.

Conventionally, various techniques for disinfecting contact lenses using the high bactericidal power of hydrogen peroxide have been studied. In the disinfection technique, contact lenses are disinfected by immersing them in a disinfectant solution containing hydrogen peroxide at a sufficiently high concentration, but after disinfection, the contact lenses are not irritating when worn on the eyes. Therefore, it is desired that hydrogen peroxide in the disinfectant solution is decomposed to a sufficiently low concentration. Therefore, for the decomposition of hydrogen peroxide (2H ₂ O ₂ → 2H ₂ O + O ₂ ), the hydrogen peroxide concentration is maintained at a sufficiently high concentration for a predetermined time from the start of disinfection, but is sufficiently low after a predetermined time. It is required to realize the hydrogen peroxide concentration.

As the decomposition treatment of hydrogen peroxide, it is known that the decomposition of hydrogen peroxide is promoted by using a catalyst supporting an active metal having hydrogen peroxide decomposition activity such as platinum. For example, in Patent Document 1, by using platinum fine particles immobilized on a carrier, hydrogen peroxide is decomposed to a sufficiently low concentration after a lapse of a predetermined time while effectively disinfecting contact lenses with hydrogen peroxide. It is disclosed to do. However, the hydrogen peroxide decomposition catalyst of Patent Document 1 has room for further improvement in terms of durability.

JP 2017-159228

The present invention has been made to solve the above-mentioned conventional problems, and its main purpose is to provide a decomposition catalyst for hydrogen peroxide having improved durability.

According to one aspect of the present invention, it is a decomposition catalyst of hydrogen peroxide for disinfecting contact lenses, which comprises a carrier and fine particles containing platinum immobilized on the carrier, wherein the carrier is a base material. And a coating layer provided on the surface of the substrate, the coating layer containing a repeating unit having an aromatic ring substituted with two or more hydroxyl groups and a heteroatom having a lone electron pair. A catalyst is provided, including.
In one embodiment, the aromatic ring substituted with the two or more hydroxyl groups is the ortho-dihydroxybenzene ring.
In one embodiment, the coating layer comprises polycatecholamines obtained by polymerizing catecholamines.
In one embodiment, the coating layer comprises polydopamine.
In one embodiment, the average particle size of the fine particles is 1000 nm or less.
According to another aspect of the present invention, a carrier in which a coating layer containing polycatecholamine is formed on the surface of the base material by polymerizing the catecholamines in a state where the solution containing the catecholamines is in contact with the base material. To obtain, to attach an irradiation solution containing platinum ions to the carrier, and to irradiate the carrier to which the irradiation solution is attached with radiation to immobilize fine particles containing platinum on the surface of the carrier. A method for producing a decomposition catalyst for the above-mentioned hydrogen peroxide for disinfecting contact lenses, which comprises the above.
In one embodiment, the substrate is subjected to a hydrophilization treatment prior to contact with the solution containing the catecholamines.
In one embodiment, the carrier on which the coating layer is formed is subjected to an ultrasonic cleaning treatment before the irradiation solution is attached.
According to yet another aspect of the present invention, a method for disinfecting a contact lens, which comprises immersing the contact lens and the decomposition catalyst of the hydrogen peroxide for disinfecting the contact lens in a contact lens disinfectant solution containing hydrogen peroxide. Is provided.

According to the present invention, by immobilizing fine particles containing platinum on a carrier having a specific coating layer, a hydrogen peroxide decomposition catalyst having excellent durability is provided.

It is the schematic sectional drawing of the catalyst by one Embodiment of this invention. It is a Si2p-XPS spectrum obtained for each carrier. It is a graph which shows the surface Si element ratio of each carrier. It is a graph which shows the weight of platinum immobilized on each carrier. It is a graph which shows the change of the residual hydrogen peroxide concentration at the time of repeated use. It is a graph which shows the change of the residual hydrogen peroxide concentration at the time of repeated use. It is a Si2p-XPS spectrum obtained for each carrier. It is a graph which shows the weight of platinum immobilized on each carrier. It is an SEM observation image of a base material, a carrier and a catalyst. It is a graph which shows the change of the residual hydrogen peroxide concentration at the time of repeated use. It is a graph which shows the change of the residual hydrogen peroxide concentration at the time of repeated use. It is a graph which shows the change of the residual hydrogen peroxide concentration at the time of repeated use.

Hereinafter, embodiments of the present invention will be described, but the present invention is not limited to the embodiments.

[A. catalyst]
FIG. 1 is a schematic cross-sectional view of a catalyst according to one embodiment of the present invention. The decomposition catalyst 100 of hydrogen peroxide for contact lens disinfection includes a carrier 10 and platinum-containing fine particles (hereinafter, platinum-containing fine particles) 20 immobilized on the carrier 10. The carrier 10 has a base material 12 and a coating layer 14 provided on the surface thereof. In the illustrated example, the coating layer 14 is provided on the entire surface of the base material 12 and the platinum-containing fine particles 20 are immobilized. However, the formation of the coating layer 14 and / or the immobilization of the platinum-containing fine particles 20 is performed. It may be applied to only a part of the surface of the base material 12 (for example, only one side).

When the catalyst is immersed in a 10 mL hydrogen peroxide solution at room temperature (about 25 ° C.), the hydrogen peroxide concentration before immersion is preferably 1% or less, more preferably 0, over a 6-hour immersion period. When immersed in a hydrogen peroxide solution up to a concentration of .5% or less, more preferably 0.2% or less (for example, 3.5% by weight (35000 ppm) of hydrogen peroxide solution, preferably 350 ppm or less, more preferably 175 ppm or less, More preferably, it can decompose hydrogen peroxide (to a concentration of 70 ppm or less).

In the above catalyst, the total weight of platinum immobilized on the carrier (hereinafter, may be referred to as "platinum-supported weight of catalyst") is preferably 1 μg to 300 μg, and more preferably 1 μg to 100 μg. Further, in the catalyst of the present invention, the weight of the immobilized platinum per geometric surface area of the carrier is preferably 0.01 μg / cm ² to 300 μg / cm ² , more preferably 0.01 μg / cm ² to 100 μg. / Cm ² .

[A-1. Base material]
Any suitable material can be used as the material for forming the base material. Examples of the material for forming the base material include inorganic materials such as metal, glass and ceramic, and organic materials such as synthetic resin. Organic materials such as synthetic resins can be more advantageous than inorganic materials in terms of moldability, operability, price and the like. Another advantage is that it does not require firing at a high temperature.

Specific examples of synthetic resins include acrylonitrile-butadiene-styrene (ABS) resin, polyethylene (PE) resin, polypropylene (PP) resin, polyurethane (PU) resin, modified polyphenylene ether (PPE) resin, and polystyrene (PS) resin. Polycarbonate (PC) resin, polyethylene terephthalate (PET) resin, polybutylene terephthalate (PBT) resin, polyvinyl chloride (PVC) resin, polyetherimide (PEI) resin, polysulfone (PSU) resin, polymethylmethacrylate (PMMA) resin , Silicone (= polydimethylsiloxane: PDMS) resin, fluorine (PTFE, PFA, ETFE, etc.) resin and copolymer resins thereof. Among them, acrylonitrile, butadiene, styrene (ABS) resin, polyethylene (PE) resin, polypropylene (PP) resin, and their copolymers, from the viewpoints of moldability, price, durability against hydrogen peroxide, adhesion of platinum-containing fine particles, etc. Polyethylene resin is preferable. The above materials may be used alone or in combination of two or more.

The shape of the base material can be appropriately set according to the purpose and the like. The base material may be, for example, a square plate, a disk, a prism, a column, or the like. Further, from the viewpoint of increasing the geometric surface area, it may be formed so as to have a wave shape such as a sine wave, a rectangular wave, or a triangular wave.

The surface of the base material may be roughened. By roughening the surface, the specific surface area can be increased, and as a result, the surface area of the obtained carrier can be increased. Further, the platinum-containing fine particles can be firmly immobilized by the carrier. The specific surface area of the carrier can be, for example, 3 cm ² / g to 200 cm ² / g, preferably 10 cm ² / g to 100 cm ² / g.

The base material preferably has high surface hydrophilicity. By having a hydrophilic group such as an -OH group or a -COOH group on the surface, a coating layer can be suitably formed and a strong bond can be formed with the coating layer. The surface hydrophilicity of the base material may be improved by hydrophilizing the base material. Examples of the hydrophilization treatment include a dry process such as plasma treatment, corona treatment, and frame treatment, and a wet process of immersing in a chemical such as potassium permanganate or chromic acid.

[A-2. Coating layer]
The coating layer contains a repeating unit having an aromatic ring substituted with two or more hydroxyl groups and a heteroatom having an isolated electron pair (excluding the oxygen atom present in the hydroxyl group as a substituent of the aromatic ring). Contains polymers. The presence of heteroatoms and aromatic rings with lone electron pairs in the repeating units of the polymer forming the coating layer allows platinum ions and platinum particles to be contained with the coating layer (more specifically, the polymer contained in the coating layer). Since the coordination bond can be achieved, the effect of improving the carrying amount and / or durability of the platinum-containing fine particles can be achieved. Further, when an aromatic ring substituted with two or more hydroxyl groups is present in the repeating unit of the polymer forming the coating layer, even if the material for forming the base material is an organic substance, it contains a metal or a metal oxide. Even if the coating layer can be formed well.

Examples of the hetero atom having the above lone electron pair include a nitrogen atom, an oxygen atom, a sulfur atom, a phosphorus atom, a chlorine atom, an iodine atom, and a bromine atom. Among them, a nitrogen atom and an oxygen atom are preferable, and a nitrogen atom is more preferable. Heteroatoms can be used alone or in combination of two or more.

The repeating unit is typically derived from an aromatic compound having an aromatic ring substituted with two or more hydroxyl groups. The polymer may contain repeating units derived from one type of aromatic compound, or may contain repeating units derived from two or more types of aromatic compounds. In one embodiment, the aromatic compound comprises drawable hydrogen, and in one embodiment, the coating layer can be formed by self-polymerization of the aromatic compound.

As the aromatic ring, a benzene ring is preferable. Examples of the benzene ring substituted with two or more hydroxyl groups include a dihydroxybenzene ring or a trihydroxybenzene ring. It is preferably a dihydroxybenzene ring, more preferably an ortho- or para-dihydroxybenzene ring, and even more preferably an ortho-dihydroxybenzene ring. Further, the aromatic ring (preferably a benzene ring) has an alkyl group, an amino group (for example, a primary or secondary amino group), a carboxyl group, and an alkoxysilyl group (for example, trimethoxy) in addition to two or more hydroxyl groups. It may be substituted with a silyl group or a triethoxysilyl group) or the like.

In one embodiment, the aromatic compound has two or more hydroxyl groups and an alkyl group, an amino group (eg, a primary or secondary amino group), a carboxyl group, and an alkoxysilyl group (eg, an alkoxysilyl group) having a hetero atom. , Aromatic hydrocarbon substituted with one or more groups selected from (trimethoxysilyl group or triethoxysilyl group). By further containing the above-mentioned substituent in addition to the two or more hydroxyl groups, the platinum-containing fine particles can be more firmly immobilized on the carrier (more specifically, the surface of the coating layer).

Specific examples of the aromatic compound include ortho-dihydroxybenzene (hereinafter, also referred to as catecholamines) into which an alkylamine has been introduced. Catecholamines can preferably form a coating layer containing polycatecholamines by polymerization (eg, self-polymerization). Specific examples of catecholamines that can be preferably used in the present invention are shown in the following formula (I).

(During the ceremony
R ¹ and R ² each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms.
X represents a substituted or unsubstituted alkylene group having 1 to 6 carbon atoms. )

The above X is preferably a substituted or unsubstituted alkylene group having 1 to 3 carbon atoms, and more preferably a substituted or unsubstituted ethylene group. Examples of the substituent include -OH, -COOH, an alkyl group having 1 to 3 carbon atoms, an alkoxyl group having 1 to 3 carbon atoms, an alkoxyalkyl group having 2 to 4 carbon atoms, and the like.

The above R ¹ and R ² independently represent a hydrogen atom or a methyl group, respectively.

Among the catecholamines represented by the formula (I), the catecholamines of the following formulas (II) to (V) can be preferably used.

Among them, dopamine represented by the formula (II) can be preferably used. In this embodiment, the coating layer comprises polydopamine.

Polydopamine can be produced by polymerization of dopamine (eg, self-polymerization). The exact structure of polydopamine is unclear, but is typically thought to include the following repeating units:

The thickness of the coating layer is preferably 3 nm or more, more preferably 5 nm to 1000 nm (for example, 10 nm to 300 nm, and for example, 15 nm to 200 nm). By providing the coating layer having such a thickness on the surface of the base material, the platinum-containing fine particles can be firmly immobilized on the carrier, and a catalyst having excellent durability can be obtained.

[A-3. Platinum-containing fine particles]
The average particle size of the platinum-containing fine particles is, for example, 1000 nm or less, preferably 300 nm or less, more preferably 20 nm or less, still more preferably 15 nm or less, and even more preferably 10 nm or less. The average particle size is preferably 1 nm or more, more preferably 1.5 nm or more, still more preferably 2 nm or more, and even more preferably 2.5 nm or more. By setting such an average particle size, it is possible to prevent the decomposition of hydrogen peroxide from being excessively promoted at the initial stage when the catalyst and the contact lens coexist in the hydrogen peroxide solution, and it is predetermined. The residual concentration of hydrogen peroxide after a lapse of time can be reduced to a sufficiently low level.

The average particle size of the platinum-containing fine particles can be adjusted, for example, by changing the concentration of active metal ions in the irradiation solution in the production method described later. Specifically, the average particle size can be increased by increasing the concentration of active metal ions in the irradiation solution, and the average particle size can be decreased by decreasing the concentration. The average particle size of the fine particles can be determined by, for example, the following method.
≪Measurement of average particle size≫
The flakes of the catalyst to be measured are observed and imaged with a transmission electron microscope (for example, manufactured by JEOL Ltd., product number "JEM-2100"). The primary particle size of any 50 fine particles in the obtained image is measured, and the average value (geometric mean) of these is calculated as the average particle size. If the fine particles are not spherical, the major axis is measured.

The platinum-containing fine particles may further contain components other than platinum, if necessary. The content of platinum in the platinum-containing fine particles can be preferably 80% by weight to 100% by weight, more preferably 90% by weight to 100% by weight, still more preferably 95% by weight to 100% by weight.

Examples of other components that can be contained in the platinum fine particles include active metals having hydrogen peroxide decomposition activity such as palladium (Pd), iridium (Ir), ruthenium (Ru), rhodium (Rh), and osmium (Os). .. These components may be used alone or in combination of two or more.

The platinum-containing fine particles may be immobilized in a state of being scattered on the surface of the carrier, or several fine particles may be connected to each other and immobilized like a string of beads. By interspersing the fine particles, the specific surface area of the active metal can be increased and the adhesion of oxygen bubbles can be more preferably suppressed as compared with the case where the active metal is formed in layers. Further, when some fine particles are connected and fixed, high durability can be obtained.

[B. Catalyst manufacturing method]
The catalyst according to item A can be produced by any suitable method. In the method for producing the catalyst in one embodiment, a coating layer containing polycatecholamine is formed on the surface of the base material by polymerizing the catecholamines in a state where the solution containing the catecholamines is in contact with the base material. Obtaining a carrier (step of forming a coating layer), attaching an irradiation solution containing platinum ions to the carrier (adhesion step of the irradiation solution), and irradiating the carrier to which the irradiation solution is attached with radiation. The present invention comprises immobilizing the platinum-containing fine particles on the surface of the carrier (immobilization step of the platinum-containing fine particles). In this embodiment, it is preferable to subject the substrate to a hydrophilization treatment before contacting it with a solution containing catecholamines. Further, it is preferable that the carrier on which the coating layer is formed is subjected to an ultrasonic cleaning treatment before the irradiation solution is attached.

[B-1. Coating layer forming process]
In the step of forming the coating layer, a coating layer containing polycatecholamines is formed on the surface of the base material by polymerizing the catecholamines in a state where the solution containing the catecholamines is in contact with the base material. As a result, a carrier having a structure in which a coating layer containing polycatecholamine is provided on the surface of the base material can be obtained. In one embodiment, the catecholamines can be self-polymerized with the substrate immersed in a solution containing the catecholamines. In another embodiment, the catecholamines can be polymerized by using a conductive base material and immersing the base material in a solution containing catecholamines to carry out electrolytic polymerization. In the polymerization of catecholamines, the polymerization reaction can be promoted by coexisting an enzyme such as tyrosinase or laccase.

The above solution containing catecholamines is a solution in which catecholamines or salts thereof are dissolved in a solvent. Examples of catecholamines are as described in Item A. Examples of the solvent include water, ethanol, propanol and the like. As the solvent, only one kind may be used alone, or two or more kinds may be used in combination. Preferably, the solvent is water.

The concentration of catecholamines in the above solution can be, for example, 0.1 mg / mL to 10 mg / mL, preferably 1 mg / mL to 8 mg / mL, and more preferably 2 mg / mL to 6 mg / mL.

The above solution may contain any suitable additive, if desired. Examples of the additive include a pH buffer (tris hydrochloride, etc.), an enzyme (laccase secreted by the white-rot fungus Trametes versicolor, etc.) and the like. By polymerizing the solution while stirring, it is possible to increase the dissolved oxygen concentration. Further, it is possible to further promote the polymerization by bubbling oxygen gas or air gas with the above solution using a gas cylinder to increase the dissolved oxygen concentration.

The pH of the above solution is preferably 4 to 12, more preferably 7 to 9.

The liquid temperature (at the time of contact) of the above solution is preferably 10 ° C. or higher, more preferably 20 ° C. or higher, from the viewpoint of improving the reaction rate. The upper limit of the liquid temperature can be, for example, below the boiling point of the solvent.

The contact time with the above solution can be appropriately selected depending on the purpose and the like. The contact time can be, for example, 1 hour or longer, preferably 3 hours or longer, more preferably 6 hours or longer, still more preferably 12 hours or longer, still more preferably 18 hours or longer. The upper limit of the contact time is not particularly limited, but may be, for example, 72 hours, or 48 hours, for example, from the viewpoint of manufacturing efficiency. According to the above contact time, a coating layer can be preferably formed on the surface of the base material by polymerization of catecholamines (for example, self-polymerization).

As described above, a carrier having a coating layer containing polycatecholamine formed on the surface of the base material can be obtained. Typically, the resulting carrier is washed. As the cleaning liquid, water, alcohol, a mixed liquid thereof and the like can be used, and water can be preferably used.

In one embodiment, cleaning can be performed by immersing the carrier in a cleaning solution and subjecting it to sonication. By subjecting the carrier to an ultrasonic cleaning treatment after forming the coating layer, catecholamines or polymers thereof that are not bonded to the substrate or have a weak bonding force are desorbed, and a coating layer having a strong bond to the substrate remains. Therefore, a catalyst having excellent durability can be obtained.

The frequency in ultrasonic processing is, for example, 20 kHz to 100 kHz, and it is desirable to alternately oscillate three waves with different frequencies by a timer to eliminate uneven cleaning. The ultrasonic output can be, for example, 50 W to 1500 W, preferably 100 W to 1000 W. The temperature of the cleaning liquid can be, for example, 5 ° C to 90 ° C, preferably 20 ° C to 80 ° C. The washing time can be, for example, 20 seconds or more, preferably 1 minute to 30 minutes.

[B-2. Irradiation solution adhesion process]
In the step of adhering the irradiation solution, the irradiation solution containing platinum ions is brought into contact with the carrier, and the irradiation solution is adhered to the carrier. Examples of the contact method include a method of immersing the carrier in the irradiation solution, a method of applying the carrier to the irradiation solution, a method of spraying the irradiation solution onto the carrier, and the like. A method of immersing the carrier in the irradiation solution is preferable. This is because the irradiation solution can adhere well to the carrier.

The irradiation solution containing platinum ions is prepared by dissolving a soluble compound of platinum such as hexachloroplatinum (IV) acid, potassium hexachloroplatinate (IV), acetylacetonate platinum (II) or a salt thereof in water. Can be done. The concentration of platinum ions in the irradiation solution is preferably 1 mM to 200 mM, more preferably 1 mM to 100 mM, and even more preferably 1 mM to 10 mM. The irradiation solution may contain ions of an active metal having hydrogen peroxide decomposing activity other than platinum. The active metal is as described in Item A. When other active metal ions are contained, the total concentration of the active metal ions (including platinum ions) in the irradiation solution is preferably 1 mM to 200 mM, more preferably 1 mM to 150 mM, still more preferably 1 mM to 100 mM. Within this range, fine particles having a desired particle size can be preferably obtained.

The irradiation solution containing platinum ions typically further contains an alcohol having 1 to 3 carbon atoms such as methanol, ethanol, and isopropyl alcohol. Platinum ions can be suitably reduced by the function of the alcohol as a reduction aid. The content of alcohol in the irradiation solution is preferably 0.1% by volume to 30% by volume, more preferably 0.5% by volume to 10% by volume.

The irradiation solution containing platinum ions preferably further contains a particle size control agent. As the particle size control agent, a compound that can form an energetically more stable bond between an active metal such as platinum and the metal (for example, a compound that gives a mixing heat smaller than the mixing heat between the active metals such as platinum). ) Can be preferably used. Specific examples thereof include phosphorus compounds such as sodium phosphinate (NaPH ₂ O ₂ ) and sodium phosphonate (NaPHO ₃ ), and nitrogen such as sodium nitrite (NaNO ₂ ) and sodium thiosulfate (Na ₂ S ₂ O ₃ ). Examples include compounds and sulfur compounds such as sodium sulfite (Na ₂ SO ₃ ). For example, when an irradiation solution containing platinum ions and the phosphorus compound is irradiated with an electron beam, the platinum-containing fine particles react with the phosphorus compound to form a Pt-P bond, and the next platinum-containing fine particles become the core platinum-containing fine particles. The binding of atoms is blocked. By including the particle size controlling agent in this way, the growth of the platinum-containing fine particles is suppressed, and the fine particles can be further refined. The concentration of the particle size control agent in the irradiation solution is preferably 0.05 mM to 50 mM, more preferably 0.1 mM to 10 mM.

The irradiation solution containing platinum ions may further contain any constituent components such as a pH adjuster and a chelating agent, if necessary. Specific examples of the arbitrary constituents include sodium hydroxide, ammonia, tartaric acid, citric acid and the like.

[B-3. Immobilization process of platinum-containing fine particles]
In the step of immobilizing the platinum-containing fine particles, the carrier to which the irradiation solution containing platinum ions is attached is irradiated with radiation. As a result, platinum ions are reduced on the surface of the carrier, and platinum-containing fine particles are immobilized on the surface of the carrier. Irradiation may be performed on the carrier immersed in the irradiation solution, or may be performed on the carrier whose surface is wet with the irradiation solution by immersion, coating, spraying, or the like. (Dip EB method), or may be performed on a carrier in an apparently dry state after the irradiation solution is attached (dry EB method). When the dip EB method is used, there is an advantage that the cost of the irradiation solution can be suppressed.

As the radiation to be irradiated, electron beam, γ ray, X-ray or the like can be used. Among them, an electron beam is preferable because continuous irradiation is possible in an open atmosphere and an electron beam having a high dose rate has an advantage that nanoparticles can be generated and supported in 10 seconds or less.

The acceleration energy of the electron beam is preferably 0.5 MeV to 10 MeV, more preferably 1 MeV to 8 MeV. The absorbed dose to the carrier in electron beam irradiation is preferably 1 kGy to 100 kGy, and more preferably 10 kGy to 50 kGy. By irradiating the electron beam in this way, fine particles having a desired particle size can be preferably obtained.

The electron beam irradiation conditions can be appropriately set according to the purpose and the like. For example, electron beam irradiation can be performed under atmospheric pressure and room temperature conditions. The irradiation time can be appropriately set according to the active metal ion concentration, the dose of the electron beam, and the like. The irradiation time may be, for example, 1 second to 1 minute, preferably 2 seconds to 30 seconds, and more preferably 3 seconds to 10 seconds. The electron beam may be continuously irradiated or intermittently irradiated. When irradiated intermittently, the irradiation time is the total.

When the carrier immersed in the irradiation solution is irradiated with an electron beam, it is more preferable to replace the dissolved oxygen in the irradiation solution with an inert gas such as nitrogen gas or argon gas prior to the electron beam irradiation. ..

As mentioned above, the irradiation time of the electron beam is extremely short, and not only the batch type but also the belt conveyor type can be adopted for the irradiation. Therefore, the production method of the present invention is very suitable for mass production of the catalyst according to item A.

[B-4. Hydrophilization]
The hydrophilization treatment is applied to the substrate before contact with a solution containing catecholamines. The hydrophilization treatment removes contaminants such as oils and dusts existing on the surface when the base material is an inorganic material, and when the base material is an organic material, hydrophilic groups such as hydroxyl groups and carboxyl groups are removed on the surface of the base material. Improves wettability to solutions containing catecholamines and promotes the formation of bonds with catecholamines or polycatecholamines, resulting in increased platinum carrying and / or catalytic durability. An improving effect can be obtained.

Any suitable method can be used as the hydrophilization treatment. Specific examples include a dry process such as plasma treatment, corona treatment, and frame treatment, and a wet process of immersing in a chemical such as potassium permanganate or chromic acid. Since these surface treatments are well known to those skilled in the art, detailed description thereof will be omitted.

[C. Disinfection method]
The method for disinfecting a contact lens of the present invention includes immersing the contact lens and the catalyst according to item A in a contact lens disinfectant solution containing hydrogen peroxide.

The concentration of hydrogen peroxide in the contact lens disinfectant is, for example, 1.0% by weight to 5.0% by weight, preferably 2.5% by weight to 4.0% by weight.

The contact lens disinfectant may contain any suitable additive, if desired. Examples of the additive component include a chelating agent, a surfactant, an isotonic agent, a buffering agent, a thickener, a preservative and the like. These additive components may be used alone or in combination of two or more. The concentration of each additive component in the disinfectant solution can be appropriately set according to the purpose and the like.

The chelating agent improves the stability of the disinfectant solution and is effective in terms of its long-term storage. Examples of the chelating agent include EDTA (ethylenediaminetetraacetic acid) or a salt thereof, etidronic acid or a salt thereof, DTPMP [diethylenetriaminepenta (methylenephosphonic acid)], sodium tinate and the like. The concentration of the chelating agent in the disinfectant solution is generally about 0.01% by weight to 0.5% by weight.

Surfactants can impart effective contact lens cleaning effects such as lipid removing action to contact lens disinfectants. As the surfactant, known anionic surfactants, nonionic surfactants, amphoteric surfactants, and cationic surfactants generally used for liquids for contact lenses and the like can be used. Specific examples include polyethylene glycol ether of higher alcohol, polyethylene glycol ester of higher fatty acid, polyglycerin ester of higher fatty acid, polyethylene glycol ether of alkylphenol, polyethylene glycol sorbitan alkyl ester, polyoxyethylene-polyoxypropylene glycol (poroxummer), and so on. Examples thereof include ethylenediamine tetrapolyoxyethylene polyoxypropylene (poroxamine). Of these, a block copolymer of polyoxyethylene and polyoxypropylene or a derivative thereof (poloxamer or poloxamine) is preferably used.

The tonicity agent is added for the purpose of adjusting the osmotic pressure of the contact lens disinfectant solution (before and after disinfection). As the tonicity agent, a known tonicity agent generally used for a liquid agent for contact lenses or the like can be used.

The contact lens disinfectant solution can be prepared by dissolving or dispersing each component in an aqueous medium. Examples of the aqueous medium include water, physiological saline and the like. The order of addition is not limited, and the desired disinfectant can be easily obtained by adding each component sequentially or simultaneously and dispersing or dissolving them, respectively.

The amount of the contact lens disinfectant used may be an amount that allows the contact lens and the catalyst to be immersed. The amount used is, for example, 5.0 mL to 20 mL. In one embodiment, the amount of contact lens disinfectant used is, for example, 0.01 mL to 20 mL, preferably 0.05 mL to 10 mL, more preferably 0.1 mL to 5 mL, per 1 μg of platinum supported on the catalyst. obtain.

As contact lenses to be disinfected, all types of contact lenses can be applied regardless of water-containing or non-water-containing, so-called soft or hard materials. The disinfection method of the present invention is particularly suitable for soft contact lenses. As soft contact lenses, those made of water-containing hydrogels are known, and for example, hydrophilic monomers such as 2-hydroxyethyl methacrylate, N, N-dimethylacrylamide, N-vinyl-2-pyrrolidone, and methacrylate. Those formed from the polymer or copolymer of the above, those formed from a copolymer produced by copolymerizing the hydrophilic monomer with a hydrophobic monomer containing silicone, etc. Can be mentioned.

In the disinfection method of the present invention, disinfection of contact lenses with hydrogen peroxide and decomposition of hydrogen peroxide with a catalyst can be suitably compatible. The catalyst and the contact lens may coexist in the disinfectant solution from the beginning, or the catalyst may be added after the contact lens is immersed and both may coexist. In any case, it is desirable to immerse the catalyst in the disinfectant solution so that the immersion time is, for example, 30 minutes to 480 minutes, preferably 120 minutes to 360 minutes. The immersion temperature is preferably 5 ° C. to 40 ° C., more preferably 10 ° C. to 30 ° C.

In one embodiment, the concentration of hydrogen peroxide in the disinfectant solution after disinfection is, for example, 150 ppm or less, preferably 100 ppm or less. With the residual concentration of hydrogen peroxide, it is possible to avoid the occurrence of pain, irritation, etc. even if the contact lens after disinfection is worn as it is.

Hereinafter, the present invention will be described in more detail with reference to Examples, but the present invention is not limited to these Examples.

≪Platinum supported amount≫
The catalyst (Pt / ABS) obtained in the experimental example was immersed in 8 mL of aqua regia (HCl: HNO ₃ = 3: 1) to dissolve platinum fine particles. 4 mL of the obtained solution was diluted with ultrapure water to 50 mL to prepare a sample solution. Using the sample solution, the platinum concentration was measured by inductively coupled plasma atomic emission spectrometry (manufactured by Shimadzu Corporation, product number "ICPE-9000"). The weight of immobilized platinum per geometric surface area of the carrier was calculated based on the concentration obtained.
≪Measurement of hydrogen peroxide concentration≫
A titanium sulfate solution (30%, Wako Pure Chemical Industries, Ltd.) was diluted to 5%, mixed with a sample containing hydrogen peroxide, and the hydrogen peroxide concentration was measured by measuring the absorbance at 407 nm.

[Experimental Example 1] Formation of polydopamine coating layer and evaluation of immersion time dependence 1M Tris-hydrochloric acid buffer solution (pH = 8.5) (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd.) and dopamine hydrochloride (Fuji Film Wako Pure Chemical Industries, Ltd.) ) Was dissolved to prepare a 2 mg / mL dopamine (DA) solution. Slide glasses were immersed in 20 mL of DA solution under room temperature (22 ± 2 ° C.) for 0, 1, 3 or 24 hours. The slide glass was then removed from the DA solution and the surface was lightly rinsed with pure water for cleaning. Then, nitrogen gas was blown with an air gun to dry it, whereby a carrier (polydopamine (PDA) -coated slide glass) was obtained.
The obtained carrier was analyzed by X-ray photoelectron spectroscopy to obtain a Si2p-XPS spectrum. The spectra and surface Si element ratios obtained for each carrier are shown in FIGS. 2 and 3, respectively.

As shown in FIGS. 2 and 3, as the immersion time in the DA solution increases, the peak intensity derived from the substrate and the surface Si element ratio decrease. From this, by immersing the base material in the DA solution, the PDA coating layer is formed due to the self-polymerization of DA, and the PDA coating amount increases as the immersion time increases. Recognize.

[Experimental Example 2] Effect of PDA coating layer 1. Preparation of Carrier An ABS resin plate (manufactured by AS-ONE, model number "2-9229-01", geometric surface area: 6.7 cm ² ) having a length of 20 mm, a width of 15 mm and a thickness of 1 mm was used as a base material. Dopamine hydrochloride is dissolved in 1M Tris-hydrochloric acid buffer solution (pH = 8.5) to prepare a 2 mg / mL DA solution, and the substrate is added to the DA solution at room temperature (22 ± 2 ° C.). Soaked for 1, 3 or 24 hours. The substrate was then removed from the DA solution and the surface was lightly rinsed with pure water for washing. Then, nitrogen gas was blown with an air gun to dry it, whereby a carrier (PDA-coated ABS resin plate) was obtained.

2. Immobilization of Platinum-Containing Fine Particles 4.55 mL of ultrapure water, 0.05 mL of 2-propanol and 0.4 mL of 0.05 MH ₂ PtCl ₆ were added to a polystyrene container and mixed to prepare an irradiation solution. The carrier was immersed in the irradiation solution, and then electron beam irradiation was performed under irradiation conditions of an acceleration energy of 4.8 MeV, a dose of 20 kGy, and an irradiation time of about 7 seconds to immobilize platinum fine particles on the carrier. Irradiation solution The carrier was taken out from the irradiation solution, immersed in ultrapure water, and then ultrasonically washed for 10 minutes. As a result, a decomposition catalyst for hydrogen peroxide in which platinum fine particles were immobilized on a carrier was obtained. The weight of platinum immobilized on each carrier is shown in FIG.

3. 3. Durability Evaluation Each catalyst obtained as described above was immersed in 5 mL of a 3.5 wt% (35000 ppm) hydrogen peroxide aqueous solution under the condition of room temperature (22 ± 2 ° C.), and the temperature was set to 25 ° C. for each container. The concentration of residual hydrogen peroxide was measured 6 hours after being placed in a constant temperature device (manufactured by AS ONE, I-CUBE FCI-280). Thereafter, each catalyst was dried in N ₂ gun, again, immersed in 3.5 wt% aqueous hydrogen peroxide solution 5 mL, were measured residual hydrogen peroxide concentration after 6 hours. The dipping and drying treatment was repeated 10 times. The change in the residual hydrogen peroxide concentration is shown in FIG.

As shown in FIGS. 4 and 5, the catalyst having the PDA coating layer has an increased amount of platinum fine particles supported as compared with the catalyst having no PDA coating layer (immersion time 0h), and the initial stage The catalytic activity of (1st time) was improved. Further, the catalyst having no PDA coating layer has a large increase in the residual H ₂ O ₂ concentration during repeated use, but the catalyst having a PDA coating layer suppresses the increase and has a large increase in the PDA coating amount. In the catalyst (immersion time 3h, 24h), the increase amount is remarkably suppressed.

[Experimental Example 3] Effect of cleaning treatment 1
1. 1. Preparation of Carrier An ABS resin plate (manufactured by AS-ONE, model number "2-9229-01", geometric surface area: 6.7 cm ² ) having a length of 20 mm, a width of 15 mm and a thickness of 1 mm was used as a base material. Dopamine hydrochloride is dissolved in 1M Tris-hydrochloric acid buffer solution (pH = 8.5) to prepare a DA solution of 2 mg / mL, and the substrate is added to the DA solution at room temperature (22 ± 2 ° C.). Soaked for hours. Next, the base material taken out from the DA solution was immersed in pure water at room temperature and ultrasonically cleaned for 5 minutes (manufactured by AS-ONE, model number "USK-1R", frequency: 40 kHz, output: 100 W). Then, nitrogen gas was blown with an air gun to dry it, whereby a carrier (PDA-coated ABS resin plate) was obtained.

2. Immobilization of Platinum-Containing Fine Particles Similar to Experimental Example 2, platinum fine particles were immobilized on a carrier and ultrasonically cleaned to obtain a decomposition catalyst for hydrogen peroxide.

3. 3. Hydrogen peroxide resolution and durability evaluation The catalyst obtained as described above was immersed in 5 mL of a 3.5 wt% hydrogen peroxide aqueous solution under the conditions of room temperature (22 ± 2 ° C.) and remained after 6 hours. The hydrogen peroxide concentration was measured. Thereafter, each catalyst was dried in N ₂ gun, again, immersed in 3.5 wt% aqueous hydrogen peroxide solution 5 mL, were measured residual hydrogen peroxide concentration after 6 hours. The dipping and drying treatment was repeated 10 times. The change in the residual hydrogen peroxide concentration is shown in FIG. 6 (b). For comparison, FIG. 6 shows changes in the residual hydrogen peroxide concentration of the catalyst of Experimental Example 2 (catalyst prepared in the same manner except that the rinsing treatment was performed instead of the ultrasonic cleaning treatment (immersion time 24 hours)). Shown in (a)

As is clear from FIGS. 6 (a) and 6 (b), the catalyst obtained by ultrasonically cleaning the carrier taken out from the DA solution and then immobilizing the platinum fine particles is a residual H ₂ O after repeated use. _{2 It} can be seen that the increase in concentration is suppressed and the durability is improved.

[Experimental Example 4] Effect of cleaning treatment 2
Dopamine hydrochloride (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd.) is dissolved in 1M Tris-hydrochloric acid buffer solution (pH = 8.5) (manufactured by Fuji Film Wako Pure Chemical Industries, Ltd.) to prepare a 2 mg / mL dopamine (DA) solution. did. The slide glass was immersed in 20 mL of DA solution for 1 or 24 hours under the condition of room temperature (22 ± 2 ° C.). Then, the slide glass taken out from the DA solution was immersed in pure water at room temperature and ultrasonically cleaned for 5 minutes (manufactured by AS-ONE, model number "USK-1R", frequency: 40 kHz, output: 100 W). Then, nitrogen gas was blown with an air gun to dry it, whereby a carrier (PDA-coated slide glass) was obtained.
The obtained carrier was analyzed by X-ray photoelectron spectroscopy to obtain a Si2p-XPS spectrum. Further, as a comparison target, a Si2p-XPS spectrum of a carrier having an immersion time of 1 or 24 hours, which was rinsed instead of the ultrasonic cleaning treatment, was obtained. The spectra obtained for each carrier are shown in FIGS. 7 (a) or 7 (b).

As shown in FIG. 7A, the peak intensity derived from the base material is increased by ultrasonic cleaning. From this, the PDA that is not bonded to the base material is desorbed by ultrasonic cleaning, and as a result, a catalyst having a PDA coating layer that is firmly bonded to the base material (as a result, a catalyst having excellent durability). Is presumed to have been obtained. On the other hand, as shown in FIG. 7B, no peak derived from the base material was confirmed for the carrier having an immersion time of 24 hours regardless of the presence or absence of ultrasonic cleaning. It is presumed that this is because the thickness of the PDA coating layer is increased due to the long immersion time, and as a result, the surface of the substrate is not exposed even when the PDA that is not bonded to the substrate is detached. To.

[Experimental Example 5] Effect of plasma treatment 1. Preparation of Carrier An ABS resin plate (manufactured by AS-ONE, model number "2-9229-01", geometric surface area: 6.7 cm ² ) having a length of 20 mm, a width of 15 mm and a thickness of 1 mm was used as a base material. Using a plasma reactor (manufactured by Yamato Scientific Co., Ltd., "PR-501A") as a plasma processing apparatus, the substrate was subjected to plasma treatment under the following conditions. By X-ray photoelectron spectroscopy, it was confirmed that -OH groups and -COOH groups were generated on the surface of the base material after the plasma treatment.
≪Plasma processing conditions≫
Gas: He
Pressure: 100 Pa (back pressure 5 Pa)
Input power: 100W
Time: 1 minute SWR: 1.1 or less

Dopamine hydrochloride is dissolved in 1M Tris-hydrochloric acid buffer solution (pH = 8.5) to prepare a 2 mg / mL DA solution, and the DA solution is subjected to plasma treatment under the condition of room temperature (22 ± 2 ° C.). The base material was immersed for 24 hours. Next, the base material taken out from the DA solution was immersed in pure water at room temperature and ultrasonically cleaned for 5 minutes (manufactured by AS-ONE, model number "USK-1R", frequency: 40 kHz, output: 100 W). Then, nitrogen gas was blown with an air gun to dry it, whereby a carrier (a PDA-coated ABS resin plate after plasma treatment) was obtained.

2. Immobilization of Platinum-Containing Fine Particles Similar to Experimental Example 2, platinum fine particles were immobilized on a carrier and ultrasonically cleaned to obtain a decomposition catalyst for hydrogen peroxide. With respect to the obtained catalyst, the weight of platinum immobilized on the carrier was applied to the catalyst of Experimental Example 3 (catalyst produced in the same manner except that the base material was not subjected to plasma treatment (however, immersion time was 0 or 24 hours). ) Is shown in FIG. 8 together with the weight of platinum immobilized in. Further, FIG. 9 shows an SEM photograph of an ABS resin plate (base material) before plasma treatment, a carrier coated with PDA after plasma treatment, and a catalyst obtained by immobilizing platinum-containing fine particles on the carrier.

3. 3. Hydrogen peroxide resolution and durability evaluation The catalyst obtained as described above was immersed in 5 mL of a 3.5 wt% hydrogen peroxide aqueous solution under the conditions of room temperature (22 ± 2 ° C.) and remained after 6 hours. The hydrogen peroxide concentration was measured. Thereafter, the catalyst was dried in N ₂ gun, again, immersed in 3.5 wt% aqueous hydrogen peroxide solution 5 mL, were measured residual hydrogen peroxide concentration after 6 hours. The dipping and drying treatment was repeated 10 times. The change in the residual hydrogen peroxide concentration is shown in FIG. Further, as a comparison target, changes in the residual hydrogen peroxide concentration of the catalyst of Experimental Example 3 (catalyst prepared in the same manner except that the base material is not subjected to plasma treatment) are also shown in FIG.

As is clear from FIG. 8, the amount of platinum supported is increased by subjecting the substrate to plasma treatment before immersion in the DA solution. Further, as is clear from FIG. 10, by subjecting the substrate to plasma treatment before immersion in the DA solution, the initial catalytic activity is improved and the increase in the residual H ₂ O ₂ concentration during repeated use is suppressed. , Durability is improved. The reason why such an effect is exhibited is that as a result of the formation of hydrophilic groups by the plasma treatment, the formation of the PDA coating layer is promoted and the bond between the PDA coating layer and the base material is strengthened. Guess.

[Experimental example 6] Durability evaluation of mounted product 1. Preparation of carrier Plasma treatment is applied to an ABS resin base material (geometric surface area: about 10.4 cm ² ) having the same shape as the carrier used in the decomposition catalyst of hydrogen peroxide for contact lens disinfection, which has been approved as a quasi-drug. Was given. The processing conditions are the same as in Experimental Example 5. Dopamine hydrochloride is dissolved in 1M Tris-hydrochloric acid buffer solution (pH = 8.5) to prepare a 2 mg / mL DA solution, and the DA solution is subjected to the above plasma treatment under the condition of room temperature (22 ± 2 ° C.). The applied substrate was immersed for 24 hours. The base material taken out from the DA solution was immersed in pure water at room temperature and ultrasonically cleaned for 5 minutes (AS-ONE, model number "USK-1R", frequency: 40 kHz, output: 100 W). Then, nitrogen gas was blown with an air gun to dry it, whereby a carrier (a PDA-coated ABS resin plate after plasma treatment) was obtained.

2. Immobilization of Platinum-Containing Fine Particles In the same manner as in Experimental Example 2, platinum fine particles were immobilized on a carrier and ultrasonically cleaned to obtain a decomposition catalyst for hydrogen peroxide.

3. 3. Hydrogen peroxide resolution and durability evaluation The catalyst obtained as described above was immersed in 10 mL of a 3.5 wt% hydrogen peroxide aqueous solution under a temperature condition of 25 ° C., and the residual hydrogen peroxide concentration after 6 hours. Was measured. Thereafter, the catalyst was dried in N ₂ gun, again, immersed in 3.5 wt% aqueous hydrogen peroxide solution 10 mL, was measured residual hydrogen peroxide concentration after 6 hours. The dipping and drying treatment was repeated 30 times. The change in the residual hydrogen peroxide concentration (average of n = 3) is shown in FIG.

As shown in FIG. 11, even when the mounted product was used repeatedly 30 times, a practically sufficiently low residual H ₂ O ₂ concentration was achieved. The residual H ₂ O ₂ concentration of 100 ppm or less has no safety problem and is at a practical level.

[Reference example 1]
1. 1. Preparation of carrier An ABS resin plate (manufactured by AS-ONE, model number "2-9229-01", geometric surface area: 6.7 cm ² ) having a length of 20 mm, a width of 15 mm and a thickness of 1 mm was used as a base material. The substrate was plasma treated. The processing conditions are the same as in Experimental Example 5.

Acetic acid is added to pure water so that pH = 4, and a thiol-based silane coupling agent (KBM-803 manufactured by Shin-Etsu Silicone Co., Ltd.) is dissolved in this solvent to obtain a KBM-803 1 vol% solution and 2 vol%. The solution was prepared. Under the condition of room temperature (22 ± 2 ° C.), the plasma-treated substrate was immersed in this KBM-803 solution for 10 minutes. Next, the base material was taken out from the KBM-803 solution, washed with water, and then heat-treated at 80 ° C. for 10 minutes using a vacuum dryer (AVO-200NS-D manufactured by AS-ONE). Finally, the product was immersed in pure water, ultrasonically cleaned with an ultrasonic cleaner (USK-1R manufactured by AS-ONE) for 5 minutes, and blown with nitrogen gas with an air gun to dry. As a result, a carrier (ABS resin plate treated with KBM-803 after plasma treatment) was obtained.
In addition, acetic acid was added to pure water so that pH = 4, and a cross-linking agent (tetramethyl orthosilicate (TMS)) was dissolved in this solvent to prepare TMOS 1 vol% solution and 2 vol% solution at room temperature. Under the condition of (22 ± 2 ° C.), the base material subjected to the above plasma treatment was immersed in the TMOS solution for 10 minutes. Then, the base material was taken out from the TMOS solution, washed with water, and then vacuum dried (manufactured by AS-ONE). , AVO-200NS-D) was heat-treated at 80 ° C. for 10 minutes, then immersed in pure water and used in an ultrasonic cleaner (USK-1R, manufactured by AS-ONE) for more than 5 minutes. It was sonicated and dried by blowing nitrogen gas with an air gun. Further, in the same manner as above, the TMOS-coated ABS resin plate was immersed in the KBM-803 solution having the same volume percent concentration as the TMOS solution for 10 minutes, and similarly. The carrier (ABS resin treated with TMOS and KBM-803 after plasma treatment) was obtained by pulling up, washing, heat-treating, and ultrasonically washing.

2. Immobilization of Platinum-Containing Fine Particles In the same manner as in Experimental Example 2, platinum fine particles were immobilized on a carrier and ultrasonically cleaned to obtain a decomposition catalyst for hydrogen peroxide. Further, a decomposition catalyst for hydrogen peroxide as a control was obtained in the same manner except that the base material not treated with the silane coupling agent was used as the carrier.

3. 3. Hydrogen peroxide resolution and durability evaluation The catalyst obtained as described above was immersed in 5 mL of a 3.5 wt% hydrogen peroxide aqueous solution under the conditions of room temperature (22 ± 2 ° C.) and remained after 6 hours. The hydrogen peroxide concentration was measured. Thereafter, the catalyst was dried in N ₂ gun, again, immersed in 3.5 wt% aqueous hydrogen peroxide solution 5 mL, were measured residual hydrogen peroxide concentration after 6 hours. The dipping and drying treatment was repeated 5 times. The change in the residual hydrogen peroxide concentration is shown in FIG.

As shown in FIG. 12, the catalyst using the carrier treated with the silane coupling agent has an increase in the residual H ₂ O ₂ concentration during repeated use as compared with the catalyst using the carrier not subjected to the treatment. It was increasing, and the effect of improving durability could not be obtained.

The catalyst of the present invention can be suitably used in disinfecting contact lenses.

10 Carrier 12 Base material 14 Coating layer 20 Platinum-containing fine particles 100 Catalyst

Claims (9)

1. A decomposition catalyst for hydrogen peroxide for contact lens disinfection, which comprises a carrier and fine particles containing platinum immobilized on the carrier.
   The carrier has a base material and a coating layer provided on the surface of the base material.
   A catalyst in which the coating layer comprises a polymer containing repeating units having an aromatic ring substituted with two or more hydroxyl groups and a heteroatom having a lone electron pair.
2. The catalyst according to claim 1, wherein the aromatic ring substituted with the two or more hydroxyl groups is an ortho-dihydroxybenzene ring.
3. The catalyst according to claim 1, wherein the coating layer contains a polymer obtained by polymerizing catecholamines.
4. The catalyst according to claim 1, wherein the coating layer contains polydopamine.
5. The catalyst according to any one of claims 1 to 4, wherein the average particle size of the fine particles is 1000 nm or less.
6. By polymerizing the catecholamines in a state where the solution containing the catecholamines is in contact with the base material, a carrier having a coating layer containing the polycatecholamines formed on the surface of the base material can be obtained.
   Claim 1 includes attaching an irradiation solution containing platinum ions to the carrier, and irradiating the carrier to which the irradiation solution is attached with radiation to immobilize fine particles containing platinum on the surface of the carrier. The method for producing a decomposition catalyst for hydrogen peroxide for disinfecting contact lenses according to any one of 5 to 5.
7. The production method according to claim 6, wherein the base material is subjected to a hydrophilization treatment before being brought into contact with the solution containing the catecholamines.
8. The production method according to claim 6 or 7, wherein the carrier on which the coating layer is formed is subjected to an ultrasonic cleaning treatment before the irradiation solution is attached.
9. A method for disinfecting contact lenses, which comprises immersing the contact lens and the decomposition catalyst of hydrogen peroxide for disinfecting contact lenses according to any one of claims 1 to 5 in a contact lens disinfectant solution containing hydrogen peroxide.

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