WO2020194574A1 - Cylindre pour seringue femelle, ensemble seringue femelle et kit de seringue - Google Patents

Cylindre pour seringue femelle, ensemble seringue femelle et kit de seringue Download PDF

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Publication number
WO2020194574A1
WO2020194574A1 PCT/JP2019/013174 JP2019013174W WO2020194574A1 WO 2020194574 A1 WO2020194574 A1 WO 2020194574A1 JP 2019013174 W JP2019013174 W JP 2019013174W WO 2020194574 A1 WO2020194574 A1 WO 2020194574A1
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WO
WIPO (PCT)
Prior art keywords
barrel
female
syringe
barrel body
opening
Prior art date
Application number
PCT/JP2019/013174
Other languages
English (en)
Japanese (ja)
Inventor
沖原等
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to JP2021508528A priority Critical patent/JP7155402B2/ja
Priority to PCT/JP2019/013174 priority patent/WO2020194574A1/fr
Publication of WO2020194574A1 publication Critical patent/WO2020194574A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes

Definitions

  • the present invention relates to a barrel for a female syringe, a female syringe assembly, and a syringe kit.
  • Some drugs are administered by mixing two different types of drugs (two types of liquids, or one type of liquid and one type of powder) immediately before administration.
  • a syringe kit for mixing two drugs for mixing a drug in a male syringe and a drug in a female syringe is known (see, for example, Japanese Patent Application Laid-Open No. 2013-132349).
  • the barrels of the two syringes are connected to each other, and both pushers are pushed in to repeatedly move between the male and female syringes by a pumping operation. Mix the two drugs.
  • the drug has a high viscosity or is a type that is difficult to mix, even if the drug is moved between male and female syringes, it may only move without mixing, or it may take a lot of time and effort to pump. ..
  • the present invention has been made in consideration of such a problem, and even if the drug has a high viscosity or is a type that is difficult to mix, the drug can be easily transferred by a pumping operation that repeatedly moves between male and female syringes. It is an object of the present invention to provide a barrel for a female syringe, a female syringe assembly, and a syringe kit that can be mixed.
  • a barrel body in which a drug storage chamber is formed and a nozzle extending from the tip of the barrel body toward the tip and provided at the tip of a barrel for a male syringe are inserted and inserted.
  • a barrel for a female syringe provided with a fitting tube portion, and the tip portion of the barrel body portion has a hole portion for allowing liquid to flow in and out of the drug storage chamber of the barrel body portion.
  • the opening structure has a formed opening structure so that the cross-sectional shape of the liquid from the opening structure toward the drug storage chamber deviates from the circular shape centered on the center line of the barrel body. It is a barrel for a female syringe, which is configured in.
  • a second aspect of the present invention is a female syringe assembly comprising the barrel for a female syringe and a cap removably attached to the connecting cylinder portion.
  • a third aspect of the present invention is a medical liquid that is detachable from the female syringe assembly and the connecting cylinder portion of the female syringe assembly and for mixing with the drug of the female syringe assembly.
  • a syringe kit comprising a male syringe assembly having a barrel for a male syringe filled with.
  • the drug can be easily mixed by a pumping operation of repeatedly moving between male and female syringes.
  • FIG. 5 is a cross-sectional view taken along the line VI-VI in FIG.
  • FIG. 7 is a cross-sectional view taken along the line VIII-VIII in FIG. It is sectional drawing along the axial direction of the syringe kit which concerns on 4th Embodiment of this invention.
  • 9 is a cross-sectional view taken along the line XX in FIG.
  • the female syringe assembly 12A according to the first embodiment shown in FIG. 1 is used in combination with the male syringe assembly 14 (see FIG. 3) to mix two different kinds of drugs and the like immediately before administration.
  • Both the female syringe assembly 12A and the male syringe assembly 14 are configured as prefilled syringes pre-filled with contents such as drugs.
  • the female syringe assembly 12A and the male syringe assembly 14 constitute a syringe kit 10A.
  • the side connected to the male syringe assembly 14 or its direction is referred to as “tip portion” or “tip direction”, and the opposite side or opposite direction is referred to as “base end”. It is called “part” or “base end direction”.
  • the side connected to the female syringe assembly 12A or its direction is referred to as “tip portion” or “tip direction”
  • the opposite side or opposite direction is referred to as “base end portion” or “base”. Called "end direction”.
  • the female syringe assembly 12A is slidable within the female syringe barrel 16A (hereinafter, abbreviated as "female barrel 16A") made of a hollow body, the cap 18 attached to the tip of the female barrel 16A, and the female barrel 16A. It includes an inserted gasket 20, a pusher 22 connected to the gasket 20, and a drug MD filled in a drug storage chamber 17 formed by the female barrel 16A and the gasket 20.
  • the female barrel 16A has a barrel body portion 26A having a substantially cylindrical shape and a base end opening formed at the base end, a connecting cylinder portion 28 extending from the tip end portion of the barrel body portion 26A toward the tip end, and a barrel body portion. It has a flange portion 30 formed so as to project radially outward from the base end of 26A.
  • the connecting cylinder portion 28 extends from the tip end of the barrel body portion 26A toward the tip end.
  • the connecting cylinder portion 28 has a passage that penetrates the female barrel 16A in the axial direction and communicates with the lumen (drug storage chamber 17) of the barrel body portion 26A.
  • the connecting cylinder portion 28 is configured as a messuler having a tapered inner peripheral surface 28s whose inner diameter decreases toward the proximal end direction.
  • the tip of the barrel body 26A has an opening structure 30A in which a hole 32 for allowing liquid to flow in and out of the drug storage chamber 17 of the barrel body 26A is formed.
  • the opening structure 30A is configured such that the cross-sectional shape of the liquid from the opening structure 30A toward the drug storage chamber 17 deviates from the circular shape centered on the center line a of the barrel body portion 26A.
  • the opening structure 30A is configured so that the flow of the liquid central portion from the opening structure 30A toward the drug storage chamber 17 deviates from the center line a of the barrel body portion 26A.
  • the hole portion 32 is a position that communicates with the first opening 34 formed on the center line a of the barrel body portion 26A and is located off the center line a. It is configured to be non-circular with a second opening 36 formed in.
  • the first opening 34 is a C-shaped opening defined by an inner surface 34a along an arc centered on the center line a of the barrel body 26A.
  • the second opening 36 is an opening protruding from the first opening 34 in the radial direction of the barrel body 26A when viewed from the axial direction of the barrel body 26A.
  • the width W of the second opening 36 in the direction perpendicular to the protruding direction of the second opening 36 from the first opening 34 is smaller than the diameter D of the first opening 34.
  • the width W of the second opening 36 may be the same as the diameter D of the first opening 34 or larger than the diameter D of the first opening 34.
  • the second opening 36 has an inner surface 36a facing parallel to each other. Therefore, the second opening 36 has a straight shape having a constant width over a predetermined length. In another aspect, the second opening 36 may have a shape that decreases in width toward the tip 36e of the second opening 36, or increases in width toward the tip 36e of the second opening 36. It may have a shape to be used.
  • the cap 18 has a sealing member 44 made of an elastic member that seals the tip opening of the female barrel 16A, and a tubular main body 46 that supports the sealing member 44.
  • a female screw 48 screwed into two protrusions 40 provided on the outer surface of the connecting cylinder 28 is provided on the inner peripheral portion of the main body 46.
  • the gasket 20 is inserted into the barrel body 26A via a base opening that opens at the base end of the barrel body 26A.
  • the base end side of the barrel body 26A is hermetically sealed by the gasket 20.
  • the gasket 20 is made of an elastic material such as a rubber material.
  • the outer peripheral portion of the gasket 20 is in liquid-tight contact with the inner peripheral surface of the barrel body portion 26A over the entire circumference, and the gasket 20 is slidably arranged in the barrel body portion 26A.
  • a gasket 20 is connected to the tip of the pusher 22.
  • the gasket 20 slides in the barrel body 26A in the axial direction.
  • the pusher 22 may be connected to the gasket 20 when the female syringe assembly 12A is used.
  • the drug MD in the female barrel 16A is a powder as long as it is dissolved, diluted, and mixed by the medical liquid ML (specifically, a solution such as physiological saline) filled in the male syringe assembly 14.
  • the medical liquid ML specifically, a solution such as physiological saline
  • Any kind of chemical, freeze-dried chemical, solid chemical, liquid chemical and the like may be used.
  • Examples of such drug MD include protein preparations, peptide preparations, antitumor agents, vitamin agents (multivitamin agents), various amino acids, antithrombotic agents such as heparin, insulin, antibiotics, analgesics, cardiac stimulants, and static drugs. Injections Anesthesia, medical narcotics, antithrombotic agents, ulcer treatment agents, corticosteroid agents, arrhythmia agents and the like can be mentioned.
  • the drug MD is not pre-filled in the female syringe assembly 12A as in the present embodiment, but may be sucked in a required amount from a vial
  • the male syringe assembly 14 includes a barrel 50 for a male syringe made of a hollow body (hereinafter, abbreviated as “male barrel 50”) and a gasket 52 slidably inserted into the male barrel 50. , A pusher 54 connected to the gasket 52, and a medical liquid ML filled in a filling space 51 formed by the male barrel 50 and the gasket 52.
  • the male barrel 50 has a barrel body 56 having a substantially cylindrical shape and a base end opening formed at the base end, a nozzle 58 provided at the tip of the barrel body 56, and a lock provided on the outside of the nozzle 58. It has an adapter 60 and a flange portion 62 projecting radially outward from the base end of the barrel body portion 56.
  • the nozzle 58 has a diameter reduced from the center of the tip of the barrel body 56 with respect to the barrel body 56 and extends toward the tip.
  • the nozzle 58 has a passage 58a that penetrates in the axial direction and communicates with the cavity (filling space 51) of the barrel body 56.
  • the nozzle 58 is configured as an male lure having a circular outer shape in cross section and a tapered outer peripheral surface 58s whose outer diameter decreases toward the tip end.
  • the nozzle 58 can be fitted to the connecting cylinder portion 28 (messuler) of the female barrel 16A.
  • a cap (not shown) is attached to the nozzle 58, and the tip opening of the nozzle 58 is sealed by this cap. This cap is removed from the nozzle 58 when the male syringe assembly 14 is used (when the syringe kit 10A is used).
  • the lock adapter 60 has a substantially hollow cylindrical shape that extends from the tip of the barrel body 56 toward the tip and concentrically surrounds the nozzle 58.
  • a screw 61 is formed on the inner peripheral surface of the lock adapter 60. The screw 61 can be screwed with two protrusions 40 provided on the tip cylinder portion of the female barrel 16A.
  • the gasket 52 is inserted into the barrel body 56 via a base opening that opens at the base end of the barrel body 56.
  • the base end side of the barrel body 56 is hermetically sealed by the gasket 52.
  • the gasket 52 is made of an elastic material such as a rubber material.
  • the outer peripheral portion of the gasket 52 is in close contact with the inner peripheral surface of the barrel body portion 56, and the gasket 52 is slidably arranged in the barrel body portion 56.
  • a gasket 52 is connected to the tip of the pusher 54.
  • the gasket 52 slides in the barrel body 56 in the axial direction.
  • the pusher 54 may be connected to the gasket 52 when the male syringe assembly 14 is used.
  • the medical liquid ML in the male barrel 50 is a liquid capable of dissolving, diluting or mixing the drug MD in the female barrel 16A.
  • a drug MD may be a drug solution such as physiological saline, a drug diluent, a drug mixture, or a drug solution containing a drug (for example, vitamins, minerals).
  • the medical liquid ML is not previously filled in the male syringe assembly 14 as in the present embodiment, but may be sucked into the empty male syringe assembly 14 from a vial or the like as needed. ..
  • the cap 18 is removed from the connecting cylinder 28 of the female barrel 16A, and the cap (not shown) is removed from the nozzle 58 of the male barrel 50.
  • the female barrel 16A and the male barrel 50 are connected to each other.
  • the screw 61 of the lock adapter 60 and the protrusion 40 (see FIG. 1) provided on the connecting cylinder portion 28 of the female barrel 16A are screwed together.
  • the nozzle 58 (male lure) of the male barrel 50 is inserted into the connecting cylinder portion 28 (mesulur) of the female barrel 16A.
  • the tapered outer peripheral surface 58s of the nozzle 58 is liquid-tightly fitted to the tapered inner peripheral surface 28s of the connecting cylinder portion 28.
  • the medical liquid ML and the drug MD are mixed by performing a pumping operation using the pusher 54 of the male syringe assembly 14 and the pusher 22 of the female syringe assembly 12A.
  • the pusher 54 of the male syringe assembly 14 is pressed toward the female syringe assembly 12A.
  • the medical liquid ML is injected into the female barrel 16A from the male barrel 50, and the medical liquid ML and the drug MD are mixed in the female barrel 16A.
  • the pusher 22 of the female syringe assembly 12A is pressed toward the male syringe assembly 14.
  • the mixed solution (a mixture of the medical liquid ML and the drug MD) is injected into the male barrel 50 from the female barrel 16A.
  • the dissolution, dilution or mixing of the drug MD is promoted, and the desired drug solution is adjusted.
  • the female barrel 16A female syringe assembly 12A, syringe kit 10A
  • the female barrel 16A female syringe assembly 12A, syringe kit 10A
  • the opening structure 30A has a cross-sectional shape of the liquid from the opening structure 30A toward the drug storage chamber 17 centered on the center line a of the barrel body 26A. It is configured to have a shape that deviates from the circular shape. Therefore, the cross-sectional shape of the liquid immediately after flowing into the female barrel 16A from the male barrel 50 during the pumping operation is as shown in FIG. In this way, the cross-sectional shape SL of the liquid L flowing from the hole 32 into the female barrel 16A (drug storage chamber 17) is different from the circular SC centered on the center line a of the barrel body 26A. A flow turbulence is generated in the female barrel 16A. As a result, the contents of the female barrel 16A and the male barrel 50 can be easily mixed by the pumping operation.
  • the opening structure 30A is configured so that the flow of the liquid central portion from the opening structure 30A toward the drug storage chamber 17 deviates from the center line a of the barrel body portion 26A. With this configuration, flow turbulence is likely to be effectively generated in the female barrel 16A, and mixing by the pumping operation can be further facilitated.
  • the hole portion 32 is formed at a position communicating with the first opening 34 formed on the center line a of the barrel body portion 26A and the first opening 34 and deviating from the center line a. It is configured to be non-circular with a second opening 36. Therefore, it is possible to easily mix the chemicals and the like by the pumping operation with a simple opening shape.
  • the syringe kit 10B includes a female syringe assembly 12B and a male syringe assembly 14 that are detachable from each other.
  • the female syringe assembly 12B has a barrel 16B for a female syringe (hereinafter, abbreviated as “female barrel 16B”).
  • female syringe assembly 12B in the initial state the cap 18 (see FIG. 1) is attached to the connecting cylinder portion 28 of the female barrel 16B.
  • a cap (not shown) is attached to the nozzle 58.
  • the tip of the barrel body 26B of the female barrel 16B has an opening structure 30B in which a hole 72 for allowing liquid to flow in and out of the drug storage chamber 17 of the barrel body 26B is formed.
  • the opening structure 30B is configured such that the cross-sectional shape of the liquid from the opening structure 30B toward the drug storage chamber 17 deviates from the circular shape centered on the center line a of the barrel body portion 26B.
  • the center of the hole 72 is off the center line a of the barrel body 26B.
  • the opening shape of the hole portion 72 in one embodiment is circular when viewed from the axial direction of the barrel body portion 26B.
  • the opening shape of the hole portion 72 may be non-circular (elliptical shape, polygonal shape, etc.) when viewed from the axial direction of the barrel body portion 26B.
  • the non-center of the hole 72 may exist on the center line a of the barrel body 26B.
  • the opening structure 30B has a cross-sectional shape of the liquid from the opening structure 30B toward the drug storage chamber 17 at the center of the barrel body 26B. It is configured to have a shape deviating from the circle centered on the line a. Therefore, as in the first embodiment, when the liquid flows from the inside of the male barrel 50 into the female barrel 16B through the opening structure 30B (hole 72) by the pumping operation, the flow is turbulent in the female barrel 16B. .. As a result, the contents of the female barrel 16B and the male barrel 50 can be easily mixed.
  • the center of the hole 72 is deviated from the center line a of the barrel body 26B. With such a configuration, it is possible to realize easy mixing by a pumping operation without adopting a complicated shape as the opening shape of the hole portion 72.
  • the syringe kit 10C includes a female syringe assembly 12C and a male syringe assembly 14 that are detachable from each other.
  • the female syringe assembly 12C has a barrel 16C for a female syringe (hereinafter, abbreviated as “female barrel 16C”).
  • female syringe assembly 12C in the initial state the cap 18 (see FIG. 1) is attached to the connecting cylinder portion 28 of the female barrel 16C.
  • a cap (not shown) is attached to the nozzle 58.
  • the tip of the barrel body 26C of the female barrel 16C has an opening structure 30C in which a hole 82 for allowing liquid to flow in and out of the drug storage chamber 17 of the barrel body 26C is formed.
  • the opening structure 30C is configured such that the cross-sectional shape of the liquid from the opening structure 30C toward the drug storage chamber 17 deviates from the circular shape centered on the center line a of the barrel body portion 26C.
  • the hole 82 is formed on the center line a of the barrel body 26C.
  • the hole 82 according to one embodiment has a circular opening, and the center line of the hole 82 coincides with the center line a of the barrel body 26C.
  • the hole 82 may have a non-circular opening (oval, polygonal, etc.).
  • the center line of the hole 82 may deviate from the center line a of the barrel body 26C.
  • the opening structure 30C further has a hollow protrusion 86 protruding in the proximal direction from the wall forming the tip of the barrel body 26C.
  • the protrusion 86 communicates with the hole 82 and communicates with the central flow path 87 formed on the center line a of the barrel body 26C, and communicates with the central flow path 87 toward the outer side in the radial direction of the barrel body 26C. It has an open side opening 88.
  • the cross-sectional shape of the protrusion 86 on the plane perpendicular to the center line a of the barrel body 26C is arcuate (C-shaped).
  • the cross-sectional shape of the protrusion 86 may be an elliptical shape, a polygonal shape, or the like.
  • a base end opening 86a is formed at the base end of the protrusion 86.
  • the side opening 88 is a slit-shaped opening extending along the central flow path 87.
  • the side opening 88 reaches the base end of the protrusion 86 and communicates with the base end opening 86a of the protrusion 86.
  • not only one side opening 88 but also a plurality of side openings 88 may be provided at intervals in the circumferential direction of the protrusion 86.
  • a gasket 20a having a recess 21 is connected to the tip of the pusher 22.
  • the tip of the gasket 20a is provided with a recess 21 that opens on the tip surface of the gasket 20a.
  • the recess 21 is recessed toward the base end of the gasket 20a, and is provided at a position facing the protrusion 86 (front position of the protrusion 86). Therefore, in the embodiment shown in FIG. 7, the recess 21 is provided on the center line a of the barrel body portion 26C.
  • the inner diameter of the recess 21 is larger than the outer diameter of the protrusion 86.
  • the opening structure 30C has a cross-sectional shape of the liquid from the opening structure 30C toward the drug storage chamber 17 at the center of the barrel body 26C. It is configured to have a shape deviating from the circle centered on the line a. Therefore, as in the first embodiment, when the liquid is made to flow from the inside of the male barrel 50 into the female barrel 16C through the opening structure 30C by the pumping operation, the flow is disturbed in the female barrel 16C. As a result, the contents of the female barrel 16C and the male barrel 50 can be easily mixed.
  • the protrusion 86 is provided with the side opening 88, when the liquid moves from the male barrel 50 into the female barrel 16C due to the pumping operation, the liquid is the base of the protrusion 86. It flows into the female barrel 16C not only from the end opening 86a but also from the side opening 88. The liquid flowing into the female barrel 16C from the side opening 88 causes a flow toward the inner peripheral surface side of the barrel body 26C. Therefore, a larger flow turbulence can be generated in the female barrel 16C. Thereby, the contents of the female barrel 16C and the male barrel 50 can be mixed more easily.
  • the syringe kit 10D includes a female syringe assembly 12D and a male syringe assembly 14 that are detachable from each other.
  • the female syringe assembly 12D has a female syringe barrel 16D (hereinafter, abbreviated as “female barrel 16D”).
  • female syringe assembly 12D in the initial state the cap 18 (see FIG. 1) is attached to the connecting cylinder portion 28 of the female barrel 16D.
  • a cap (not shown) is attached to the nozzle 58.
  • the tip of the barrel body 26D of the female barrel 16D has an opening structure 30D in which a hole 92 for allowing liquid to flow in and out of the drug storage chamber 17 of the barrel body 26D is formed.
  • the opening structure 30D is configured such that the cross-sectional shape of the liquid from the opening structure 30D toward the drug storage chamber 17 deviates from the circular shape centered on the center line a of the barrel body portion 26D.
  • the hole 92 is formed on the center line a of the barrel body 26D and has a non-circular opening shape.
  • the hole 92 has a polygonal opening shape, specifically a square opening shape.
  • the hole 92 may have a rectangular opening shape, a triangular opening shape, or another non-circular opening shape such as a star. Good.
  • the cross-sectional shape of the liquid from the opening structure 30D toward the drug storage chamber 17 is the center of the barrel body 26D. It is configured to have a shape deviating from the circle centered on the line a. Therefore, as in the first embodiment, when the liquid flows from the inside of the male barrel 50 into the female barrel 16D through the opening structure 30D (hole 92) by the pumping operation, the flow is turbulent in the female barrel 16D. .. As a result, the contents of the female barrel 16D and the male barrel 50 can be easily mixed.
  • the barrel body (26A to 26D) in which the drug storage chamber (17) is formed and the tip of the barrel (50) for a male syringe are extended from the tip of the barrel body toward the tip.
  • the opening structure (30A to 30C) may be configured such that the flow of the central portion of the liquid from the opening structure toward the drug storage chamber deviates from the center line of the barrel body portion.
  • the hole (32) has a first opening (34) formed on the center line of the barrel body and a second opening (34) formed at a position communicating with the first opening and deviating from the center line. It may be configured in a non-circular shape having 36) and.
  • the center of the hole (72) may be off the center line of the barrel body.
  • the hole (82) is formed on the center line of the barrel body, and the opening structure (30C) has a hollow shape protruding from the wall constituting the tip of the barrel body toward the proximal end. (86), the protrusion communicates with the hole portion and communicates with the central flow path (87) formed on the center line of the barrel body portion, and communicates with the central flow path. It may have a lateral opening (88) that opens outward in the radial direction of the barrel body.
  • the hole (92) may be formed on the center line of the barrel body and may have a non-circular opening shape.
  • the hole (92) may have a polygonal opening shape.
  • the above-described embodiment discloses a female syringe assembly (12A to 12D) including any of the barrels for a female syringe and a cap (18) removably attached to the connecting cylinder portion. ..
  • a drug (MD) filled in the drug storage chamber of the barrel body a gasket (20) arranged in the barrel body and slidable in the barrel body, and the like. It may be configured as a prefilled syringe equipped with.
  • the female syringe assembly configured as a prefilled syringe is detachable from the connecting cylinder portion of the female syringe assembly, and is mixed with the drug of the female syringe assembly.
  • a syringe kit (10A-10D) comprising a male syringe assembly (14) having a barrel for a male syringe filled with the medical liquid (ML) of.
  • the present invention is not limited to the above-described embodiment, and various modifications can be made without departing from the gist of the present invention.
  • the configurations of the opening structures 30A to 30D may be adopted in appropriate combinations.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

La présente invention concerne un kit de seringue (10A) équipé d'un ensemble seringue femelle (12A) et d'un ensemble seringue mâle (14). L'ensemble seringue femelle (12A) comprend un cylindre (16A) pour seringue femelle. L'extrémité distale d'un corps de cylindre (26A) du cylindre (16A) pour seringue femelle a une structure d'ouverture (30A) dans laquelle est formé un trou (32) pour permettre à un liquide de s'écouler dans et hors d'une chambre de stockage de médicament (17) dans le corps de cylindre (26A). La structure d'ouverture (30A) est conçue de telle sorte que la forme en coupe transversale du liquide s'écoulant de la structure d'ouverture (30A) vers la chambre de stockage de médicament (17) est une forme non ronde à partir d'un cercle centré sur la ligne centrale (a) du corps de cylindre (26A).
PCT/JP2019/013174 2019-03-27 2019-03-27 Cylindre pour seringue femelle, ensemble seringue femelle et kit de seringue WO2020194574A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021508528A JP7155402B2 (ja) 2019-03-27 2019-03-27 メスシリンジ用バレル、メスシリンジ組立体及びシリンジキット
PCT/JP2019/013174 WO2020194574A1 (fr) 2019-03-27 2019-03-27 Cylindre pour seringue femelle, ensemble seringue femelle et kit de seringue

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2019/013174 WO2020194574A1 (fr) 2019-03-27 2019-03-27 Cylindre pour seringue femelle, ensemble seringue femelle et kit de seringue

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WO2020194574A1 true WO2020194574A1 (fr) 2020-10-01

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002516725A (ja) * 1998-06-05 2002-06-11 アボット・ラボラトリーズ 薬剤を保存、混合および投与するためのシステム
US20050209555A1 (en) * 2004-03-18 2005-09-22 Lance Middleton Systems and methods for mixing fluids
JP2013132349A (ja) * 2011-12-26 2013-07-08 Daikyo Seiko Ltd 二薬混合用シリンジキット
JP2014028040A (ja) * 2012-07-31 2014-02-13 Yoshino Kogyosho Co Ltd 混合噴出器
WO2016163444A1 (fr) * 2015-04-07 2016-10-13 日産化学工業株式会社 Procédé de préparation d'une composition de milieu liquide, et dispositif de préparation et trousse associée

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ597281A (en) 2009-09-08 2013-07-26 Baxter Int Syringe for mixing components for wound sealant with screens in each of male and female plunger parts

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002516725A (ja) * 1998-06-05 2002-06-11 アボット・ラボラトリーズ 薬剤を保存、混合および投与するためのシステム
US20050209555A1 (en) * 2004-03-18 2005-09-22 Lance Middleton Systems and methods for mixing fluids
JP2013132349A (ja) * 2011-12-26 2013-07-08 Daikyo Seiko Ltd 二薬混合用シリンジキット
JP2014028040A (ja) * 2012-07-31 2014-02-13 Yoshino Kogyosho Co Ltd 混合噴出器
WO2016163444A1 (fr) * 2015-04-07 2016-10-13 日産化学工業株式会社 Procédé de préparation d'une composition de milieu liquide, et dispositif de préparation et trousse associée

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