WO2020180272A1 - Potable boron solution - Google Patents

Potable boron solution Download PDF

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Publication number
WO2020180272A1
WO2020180272A1 PCT/TR2020/050157 TR2020050157W WO2020180272A1 WO 2020180272 A1 WO2020180272 A1 WO 2020180272A1 TR 2020050157 W TR2020050157 W TR 2020050157W WO 2020180272 A1 WO2020180272 A1 WO 2020180272A1
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WO
WIPO (PCT)
Prior art keywords
boron
potable
solution
content
bacteria
Prior art date
Application number
PCT/TR2020/050157
Other languages
French (fr)
Inventor
Alaaddin GÜNDEŞ
Selçuk NAZİK
Hülya NAZİK
Kezban Tülay YALÇINKAYA
Akif Hakan KURT
Hakan YAYKAŞLI
Ferudun KOÇER
Filiz ORAK
Original Assignee
Kahramanmaraş Sütçü İmam Üni̇versi̇tesi̇
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kahramanmaraş Sütçü İmam Üni̇versi̇tesi̇ filed Critical Kahramanmaraş Sütçü İmam Üni̇versi̇tesi̇
Publication of WO2020180272A1 publication Critical patent/WO2020180272A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Definitions

  • This invention concerns the potable boron solution applied particularly in textile, polymer chemistry, metal, paper, healthcare and cosmetic industries.
  • Liquid and cream products manufactured with boron and nano-boron are available on the market.
  • the pure boron content ranges between 0.3 and 7 ppm.
  • Antibiotic, antifungal or antiviral agents are used to avoid the micro-organisms such as bacteria, fungi and virus.
  • supplementary disinfectants are used in certain cases.
  • Acinetobacter baumanni is the major nosocomial pathogen with particular impact on intensive care patients. This bacterium stands as one of the main consequences of nosocomial mortality and morbidity.
  • Various medications are available for the treatment of this bacterium. Yet, such medications would injure kidneys, lungs or both.
  • Today, a solution with pure boron content is required to eliminate such bacteria types apart from antibiotics or disinfectants.
  • the product contains 25% of sodium decarbonate, 25% of copper sulfate, 15% of boric acid, 10% of borax and 25% of zinc oxide. According to the findings, this procedure intends to homogenize zinc oxide with borax. Sodium decarbonate, boric acid and copper sulfate are added respectively for 5 minutes. The mixture is then kept for 10 minutes to homogenize. Depending on the level of wood contamination, the product is used at a certain dilution rate of 1 :20...30 for prevention or application purposes.
  • the compound micro-organism bacteria solution and the mixing method defines the compound micro-organism bacteria solution and the mixing method for single layer urine.
  • the compound micro-organism bacteria solution contains following raw agents distributed by weight: Section 0.5-1 contains the compound micro-organism bacteria; Section 2 contains beet sugar, and Section 97.5 contains clean water.
  • TR201412010,“Disinfectant” In the patent application numbered TR201412010,“Disinfectant” is described.
  • This invention concerns the disinfectant solution applied to cease reproduction and to eliminate all micro-organisms and bacteria that threatens human health in (grounds and walls) hospitals, houses, pools, schools and public places.
  • SUBSTITUTE SHEETS (RULE 26) human health, environment or ecological balance although it is used in laundry and washing-up.
  • This invention is a potable boron solution that overcomes the above-mentioned disadvantages. It is a new technology based on pure boron that eliminates all bacteria and micro-organisms without antibiotics, that destroys the habitat developed by fungi and that removes“ Acinetobacter baumanni” by itself.
  • the boron content ranges between pH 7 and 8.
  • the boron is effective for wound treatment in addition to its antibacterial, antifungal and antiviral features.
  • the product subjected to this invention is obtained following three phases.
  • the invention intends to extract pure boron, which is not available in nature. For this reason, certain procedures should be performed on the boron content.
  • the average MIC90 (Minimum Inhibitory Concentration) rates are indicated.
  • the product subjected to this invention is obtained following three phases.
  • the purpose of this invention is as follows: First, it is necessary to obtain pure boron.
  • the boron available in nature is not a pure type. For this reason, certain procedures should be performed on the boron content.
  • boric oxide (10) is extracted by reacting boric acid with borax.
  • boric acid is mixed with borax.
  • pure boron (20) is extracted by reducing the boric oxide content.
  • distillation (30) is
  • the product subjected to this invention has boron content with the pH rate between 7 and 8 at ambient temperature (24,6°C). On the other hand, the boron content is found to range between 15 and 500 ppm.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention concerns the potable boron solution applied particularly in textile, polymer chemistry, metal, paper, healthcare and cosmetic industries. By this product, it is intended to extract boric oxide (10) by reacting boric acid with borax, to extract pure boron (20) by reducing boric oxide and to perform distillation (30) at 2000 degrees.

Description

POTABLE BORON SOLUTION
Technological Scope:
This invention concerns the potable boron solution applied particularly in textile, polymer chemistry, metal, paper, healthcare and cosmetic industries.
Recognized Status of Applied Technique:
Liquid and cream products manufactured with boron and nano-boron are available on the market. However, the pure boron content ranges between 0.3 and 7 ppm. By benefiting from the current image of boron throughout the market, it is used as a subsidiary element among other active components.
The products developed with various boron derivatives available on the market such as borax, boric acid (acidic) and boron hydroxide (basic) bring toxic effect on human body. The impulse time in current systems is low (due to the low boron content in the component). Furthermore, a long time is required for reactivation.
Antibiotic, antifungal or antiviral agents are used to avoid the micro-organisms such as bacteria, fungi and virus. In addition to such agents, supplementary disinfectants are used in certain cases.“ Acinetobacter baumanni” is the major nosocomial pathogen with particular impact on intensive care patients. This bacterium stands as one of the main consequences of nosocomial mortality and morbidity. Various medications are available for the treatment of this bacterium. Yet, such medications would injure kidneys, lungs or both. Today, a solution with pure boron content is required to eliminate such bacteria types apart from antibiotics or disinfectants.
In the reference with the publication number of CN10616726A, “the boron decomposition and extraction method for a specific solution with boron content” is
1
SUBSTITUTE SHEETS (RULE 26) explained. The stated method involves following procedures: the flux of raw fluid with reference boron throughout an ion exchange column for absorbing the boron content, the subsequent discharge of remaining fluid and the filtration of ion exchange column with a leaching fluid.
In the patent application numbered RO125372A0,“The solution against bacteria” is described. According to the findings, the product contains 25% of sodium decarbonate, 25% of copper sulfate, 15% of boric acid, 10% of borax and 25% of zinc oxide. According to the findings, this procedure intends to homogenize zinc oxide with borax. Sodium decarbonate, boric acid and copper sulfate are added respectively for 5 minutes. The mixture is then kept for 10 minutes to homogenize. Depending on the level of wood contamination, the product is used at a certain dilution rate of 1 :20...30 for prevention or application purposes.
In the patent application numbered CN108117415A,“The compound micro-organism bacteria solution and the mixing method” is described. The invention defines the compound micro-organism bacteria solution and the mixing method for single layer urine. The compound micro-organism bacteria solution contains following raw agents distributed by weight: Section 0.5-1 contains the compound micro-organism bacteria; Section 2 contains beet sugar, and Section 97.5 contains clean water.
In the patent application numbered TR201412010,“Disinfectant” is described. This invention concerns the disinfectant solution applied to cease reproduction and to eliminate all micro-organisms and bacteria that threatens human health in (grounds and walls) hospitals, houses, pools, schools and public places.
In the patent application numbered TR201511580, “The method of reproducing granular detergent with borax content and the detergent developed by this method” is described. This invention concerns the production of low-density granular detergent with borax content. The antibacterial detergent does not contain hazardous chemicals like petroleum products or phosphate. The stated detergent does not pose a risk against
2
SUBSTITUTE SHEETS (RULE 26) human health, environment or ecological balance although it is used in laundry and washing-up.
In the above-mentioned patent applications, the methods applied to eliminate bacteria by a solution derived from boron are duly analyzed. The stated methods have insufficient features in removing bacteria and micro-organisms. Furthermore, the costs of stated applications are considerably high.
In conclusion, a new technology based on pure boron is required to eliminate all bacteria and micro-organisms, the habitat developed by fungi and the bacteria named “Acinetobacter baumanni” without any antibiotic standing against the above-mentioned disadvantages.
Description of the Invention:
This invention is a potable boron solution that overcomes the above-mentioned disadvantages. It is a new technology based on pure boron that eliminates all bacteria and micro-organisms without antibiotics, that destroys the habitat developed by fungi and that removes“ Acinetobacter baumanni” by itself.
According to this invention, the boron content ranges between pH 7 and 8. The boron is effective for wound treatment in addition to its antibacterial, antifungal and antiviral features.
The product subjected to this invention is obtained following three phases. The invention intends to extract pure boron, which is not available in nature. For this reason, certain procedures should be performed on the boron content.
3
SUBSTITUTE SHEETS (RULE 26)
Figure imgf000005_0001
Chart- 1 MIC50 and MIC 90 rates
A certain part of results is available on the chart. The average MIC90 (Minimum Inhibitory Concentration) rates are indicated. The average MIC90 rate is 3,07±2,4 (minimum-maksimurmO, 13-8,4) and the average MIC50 rate is 1,67±1,49 (minimum- maksimurmO, 27-8, 4) in all strains (n=ll l).
4
SUBSTITUTE SHEETS (RULE 26) Description of Figures:
This invention shall be described with reference to the attached figures. Thus, its features shall be recognized clearly. However, it is not intended to restrain this invention with certain regulations. On the contrary, the figures cover all alternatives, modifications and equivalents under the scope defined by the attached requirements. The details are provided only to describe the preferred setting of this invention. The figures are presented to develop relevant methods and to define the rules of this invention with its conceptual features. In the stated figures:
Figure 1 Refers to the flow diagram of solution
As indicated on the attached table, the figures intending to clarify this invention are duly numbered. The stated figures are given in the following section with relevant names.
Description of References:
10. Extracting boric oxide
20. Extracting pure boron
30. Distillation process
Detailed Definition of the Invention:
The product subjected to this invention is obtained following three phases. The purpose of this invention is as follows: First, it is necessary to obtain pure boron. The boron available in nature is not a pure type. For this reason, certain procedures should be performed on the boron content.
In the first phase, boric oxide (10) is extracted by reacting boric acid with borax. In other words, boric acid is mixed with borax. In the second phase, pure boron (20) is extracted by reducing the boric oxide content. In the third phase, distillation (30) is
5
SUBSTITUTE SHEETS (RULE 26) applied to pure boron at 2000 degrees. The boron solution is finally upon the distillation procedure. By this solution, all bacteria and micro-organisms are eliminated.
The product subjected to this invention has boron content with the pH rate between 7 and 8 at ambient temperature (24,6°C). On the other hand, the boron content is found to range between 15 and 500 ppm.
6
SUBSTITUTE SHEETS (RULE 26)

Claims

1- This invention refers to the potable boron solution. Following procedures are applied:
To extract boric oxide (10) by reacting boric acid with borax
To extract pure boron (20) by reducing the boric oxide content
To perform distillation (30) at 2000 degrees
2- This invention refers to the potable boron solution as specified in Claim 1. The boron content is intended to be characterized at ambient temperature (24,6°C) with the pH rate between 7 and 8.
3- This invention refers to the potable boron solution as specified in Claim 1. The boron content is intended to be characterized with the boron amount between 15 and 500 ppm.
7
SUBSTITUTE SHEETS (RULE 26)
PCT/TR2020/050157 2019-03-04 2020-02-27 Potable boron solution WO2020180272A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2019/03211A TR201903211A2 (en) 2019-03-04 2019-03-04 DRINKABLE BORON SOLUTION
TR2019/03211 2019-03-04

Publications (1)

Publication Number Publication Date
WO2020180272A1 true WO2020180272A1 (en) 2020-09-10

Family

ID=67980574

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/TR2020/050157 WO2020180272A1 (en) 2019-03-04 2020-02-27 Potable boron solution

Country Status (2)

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TR (1) TR201903211A2 (en)
WO (1) WO2020180272A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860911A (en) * 1958-10-30 1961-02-15 United States Borax Chem Preparation of pure trialkyl borates
WO2005000328A1 (en) * 2003-06-24 2005-01-06 Zanti Gianfranco Compositions based on plant ash for the treatment of skin diseases
JP2005112700A (en) * 2003-10-10 2005-04-28 Kanazawa Inst Of Technology Aqueous solution of boron compound stable in room temperature, manufacturing method and utilization of the same
CN105480986A (en) * 2014-10-15 2016-04-13 刘浩 Boric acid preparation method
WO2016205574A1 (en) * 2015-06-18 2016-12-22 Common Pharma, Inc Antimicrobial formulations

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB860911A (en) * 1958-10-30 1961-02-15 United States Borax Chem Preparation of pure trialkyl borates
WO2005000328A1 (en) * 2003-06-24 2005-01-06 Zanti Gianfranco Compositions based on plant ash for the treatment of skin diseases
JP2005112700A (en) * 2003-10-10 2005-04-28 Kanazawa Inst Of Technology Aqueous solution of boron compound stable in room temperature, manufacturing method and utilization of the same
CN105480986A (en) * 2014-10-15 2016-04-13 刘浩 Boric acid preparation method
WO2016205574A1 (en) * 2015-06-18 2016-12-22 Common Pharma, Inc Antimicrobial formulations

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BAKIRDERE, S. ET AL.: "Effect of boron on human health", THE OPEN MINERAL PROCESSING JOURNAL, vol. 3, no. 1, 2010, pages 54 - 49, XP055736337, DOI: 10.2174/1874841401003010054 *
YILMAZ, M. T.: "Minimum inhibitory and minimum bactericidal concentrations of boron compounds against several bacterial strains", TURKISH JOURNAL OF MEDICAL SCIENCES, vol. 42, no. Sup.2, 2012, pages 1423 - 1429, XP055736351, DOI: 10.3906/sag-1205-83 *

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