CN113197218A - Disinfectant and preparation method thereof - Google Patents
Disinfectant and preparation method thereof Download PDFInfo
- Publication number
- CN113197218A CN113197218A CN202110340555.0A CN202110340555A CN113197218A CN 113197218 A CN113197218 A CN 113197218A CN 202110340555 A CN202110340555 A CN 202110340555A CN 113197218 A CN113197218 A CN 113197218A
- Authority
- CN
- China
- Prior art keywords
- sodium hypochlorite
- disinfectant
- potassium bromide
- sodium
- parts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
- A01N59/08—Alkali metal chlorides; Alkaline earth metal chlorides
Abstract
The invention discloses a disinfectant and a preparation method thereof, and the disinfectant comprises the following steps: the sodium hypochlorite-potassium bromide-sodium dodecyl betaine water dispersible granule comprises, by mass, 40-60 parts of sodium hypochlorite, 1-3 parts of potassium bromide, 0.2-1.0 part of dodecyl betaine, 0.2-0.4 part of sodium hydroxide and 40-60 parts of water. The disinfectant containing sodium hypochlorite prepared by the method has good safety.
Description
Technical Field
The invention relates to a medicine processing technology, in particular to a disinfectant and a preparation method thereof.
Background
The novel coronavirus pneumonia epidemic situation outbreaked at the end of 2019 worldwide causes immeasurable loss to economic development and human health worldwide. The virus is named as 2019 novel coronavirus (2019-nCoV) by the world health organization in 1 month and 12 days in 2020. Coronaviruses are a large virus family, which are known to cause cold and more serious diseases such as Middle East Respiratory Syndrome (MERS) and Severe Acute Respiratory Syndrome (SARS), and the novel coronaviruses are new strains of coronaviruses which have not been found in human bodies before. 2019 the novel coronavirus (2019-nCoV) is the 7 th coronavirus which is known to infect human, and the other 6 are HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1, SARS-CoV and MERS-CoV, respectively.
After the epidemic situation occurs, a safe, nontoxic and broad-spectrum bactericidal disinfectant used for disinfecting hospital medical treatment, resident living environments and the like is urgently needed, and a sodium hypochlorite disinfectant is the first choice of the safe, nontoxic and residue-free disinfectant. The sodium hypochlorite disinfectant is a product widely used for killing bacteria and viruses, preventing diseases and inhibiting transmission, and has the characteristics of broad spectrum, high efficiency and safety. The disinfectant is mainly used for disinfecting surfaces of various objects, environments and the like. Is widely used for the sanitation and disinfection of hotels, tourists, hospitals, food processing industries, families and the like. Research shows that the sodium hypochlorite disinfectant has a killing function on legionella pneumophila, tubercle bacillus and the like.
Sodium hypochlorite is extremely unstable and extremely easy to decompose, and is easy to decompose and lose efficacy under the induction of light, heat, acid and heavy metals, so that the effective period is shortened, and the sterilization effect is reduced. At present, sodium hypochlorite disinfectants produced in China have poor stability, and most of the sodium hypochlorite disinfectants have a stable period of less than 3 months.
Disclosure of Invention
The invention aims to provide a disinfectant, which solves the problems that the existing disinfectant, namely sodium chlorate, is extremely unstable and extremely easy to decompose, and is easy to decompose under the induction of light, heat, acid and heavy metal to lose efficacy, so that the effective period is shortened, and the sterilization effect is lowered.
The invention provides a disinfectant, which comprises, by mass, 40-60 parts of sodium hypochlorite, 1-3 parts of potassium bromide, 0.2-1.0 part of dodecyl betaine, 0.2-0.4 part of sodium hydroxide and 40-60 parts of water.
The sodium hypochlorite-potassium bromide-sodium dodecyl betaine-sodium hydroxide powder further comprises, by mass, 40 parts of sodium hypochlorite, 1 part of potassium bromide, 0.2 part of dodecyl betaine, 0.2 part of sodium hydroxide and 40 parts of water.
The sodium hypochlorite-potassium bromide-sodium dodecyl betaine-sodium hydroxide powder further comprises the following components, by mass, 55 parts of sodium hypochlorite, 2 parts of potassium bromide, 0.6 part of dodecyl betaine, 0.35 part of sodium hydroxide and 55 parts of water.
The sodium hypochlorite-potassium bromide-sodium dodecyl betaine-sodium hypochlorite-potassium bromide-sodium dodecyl betaine-sodium hydroxide powder further comprises, by mass, 60 parts of sodium hypochlorite, 3 parts of potassium bromide, 1.0 part of dodecyl betaine, 0.4 part of sodium hydroxide and 60 parts of water.
A preparation method of a disinfectant comprises the following steps:
step one, measuring the effective chlorine content of sodium hypochlorite, and calculating the adding amount of the sodium hypochlorite and purified water (the effective chlorine content is fed according to 4-7%);
step two, weighing the dodecyl betaine and the potassium bromide according to the formula, putting the dodecyl betaine and the potassium bromide into a stirring tank, adding 30-50% of purified water, and stirring to dissolve;
putting the calculated amount of sodium hypochlorite and the balance of purified water into a stirring tank, and uniformly stirring;
adding sodium hydroxide into a stirring tank, stirring and dissolving, and adjusting the pH value;
step five, carrying out semi-finished product inspection on the disinfectant prepared in the step four;
and step six, filling the semi-finished product qualified in the step four.
Further, in the step one, the sodium hypochlorite meets the requirement of type A in GB 19106-.
Further, in the second step, the dodecyl betaine meets the QB/T2344-; the potassium bromide should meet the requirements of HG/T3808-2006 industrial grade.
Further, the amount of sodium hypochlorite used in the third step is the amount calculated in the first step; and the residual purified water is the calculated amount of the purified water in the step one minus the used amount of the purified water in the step two.
Further, the sodium hydroxide in the fourth step should meet the requirement of industrial grade IS-I in GB/T209-2018, and the pH IS adjusted to 12-13 (detected by an acidimeter).
Further, the filling specification in the sixth step is 500ml or 5L or 25L.
The invention has the advantages that:
(1) the disinfectant containing sodium hypochlorite prepared by the method has good safety.
(2) The disinfectant containing sodium hypochlorite prepared by the method has good stability, and the reduction rate of the available chlorine content is less than or equal to 15 percent at 54 +/-2 ℃ in 14 days of accelerated test.
(3) The disinfectant containing sodium hypochlorite prepared by the method has strong capability of killing microorganisms.
Detailed Description
The following is further detailed by the specific embodiments:
the disinfectant comprises, by mass, 40 parts of sodium hypochlorite, 1 part of potassium bromide, 0.2 part of dodecyl betaine, 0.2 part of sodium hydroxide and 40 parts of water.
The invention provides a preparation method of a disinfectant, which comprises the following specific steps:
step one, measuring the effective chlorine content of sodium hypochlorite, calculating the adding amount of the sodium hypochlorite and purified water (the effective chlorine content is fed according to 4-7%), wherein the sodium hypochlorite meets the A-type requirement in GB 19106-;
step two, weighing dodecyl betaine and potassium bromide according to the formula, putting the dodecyl betaine and the potassium bromide into a stirring tank, adding 30-50% of purified water, stirring to dissolve the dodecyl betaine, wherein the dodecyl betaine meets the requirement of QB/T2344-; the potassium bromide meets the requirements of HG/T3808-2006 industrial grade products;
step three, putting the calculated amount of sodium hypochlorite and the balance of purified water into a stirring tank, and uniformly stirring, wherein the amount of the sodium hypochlorite is the amount calculated in the step one; the residual purified water is obtained by subtracting the consumption of the purified water in the step two from the calculated amount of the purified water in the step one;
adding sodium hydroxide into the stirring tank, stirring and dissolving, and adjusting the pH value to 12-13 (detected by an acidimeter) when the sodium hydroxide meets the requirement of industrial grade IS-I in GB/T209-2018;
step five, carrying out semi-finished product inspection on the disinfectant prepared in the step four;
and step six, filling the semi-finished product qualified in the step four, wherein the filling specification is 500ml or 5L or 25L.
The difference between the second embodiment and the first embodiment is only that:
the sodium hypochlorite-potassium bromide-sodium dodecyl betaine-sodium hypochlorite-potassium bromide-sodium dodecyl betaine-sodium hydroxide powder comprises, by mass, 55 parts of sodium hypochlorite, 2 parts of potassium bromide, 0.6 part of dodecyl betaine, 0.35 part of sodium hydroxide and 55 parts of water.
The difference between the third embodiment and the first embodiment is only that:
the sodium hypochlorite-potassium bromide-sodium dodecyl betaine-sodium hypochlorite-potassium bromide-potassium dodecyl betaine-sodium hydroxide powder comprises, by mass, 60 parts of sodium hypochlorite, 3 parts of potassium bromide, 1.0 part of dodecyl betaine, 0.4 part of sodium hydroxide and 60 parts of water.
And (3) stability test:
the disinfectant prepared in the first to third embodiments is placed in a constant temperature test box at 54 +/-2 ℃ for 14 days, and samples are taken before and after placement to detect the available chlorine content of the stock solution. The results of the accelerated test are shown in the following table.
The results of the accelerated test are as follows:
as can be seen from the above table, the reduction rate of the effective chlorine content of the disinfectant prepared in the first to third embodiments is less than or equal to 15%, and the reduced effective chlorine content of the stock solution is greater than or equal to 4%, which meets the requirements of the disinfectant stability evaluation method GB/T38499-.
Microbiological kill test
The test microorganism Staphylococcus aureus (Staphylococcus aureus) ATCC 6538 was used as a representative of pyococcus in the bacterial propagules; escherichia coli (Escherichia coli)8099 is representative of enteric bacteria in bacterial propagules; pseudomonas aeruginosa (Pseudomonas aeruginosa) ATCC 15442 as representative of the most commonly isolated bacterial propagules in nosocomial infections; bacillus subtilis var. niger ATCC 9372 as representative of bacterial spores; candida albicans (Candida albicans) ATCC 10231 as a representative of pathogenic fungi; poliovirus type I vaccine strain (Poliovirus-I) is representative of the virus. The results of the microbial kill test are shown in the table below.
The following table shows the results of the microbial kill test
Concentration of organic interfering substances for bactericidal assay was 0.3%.
As can be seen from the above table, the disinfectants prepared in the first to third examples have strong capability of killing microorganisms.
The foregoing is merely an example of the present invention, and common general knowledge in the field of known specific structures and characteristics is not described herein in any greater extent than that known in the art at the filing date or prior to the priority date of the application, so that those skilled in the art can now appreciate that all of the above-described techniques in this field and have the ability to apply routine experimentation before this date can be combined with one or more of the present teachings to complete and implement the present invention, and that certain typical known structures or known methods do not pose any impediments to the implementation of the present invention by those skilled in the art. It should be noted that, for those skilled in the art, without departing from the structure of the present invention, several changes and modifications can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicability of the patent. The scope of the claims of the present application shall be determined by the contents of the claims, and the description of the embodiments and the like in the specification shall be used to explain the contents of the claims.
Claims (10)
1. A disinfectant, characterized by: the sodium hypochlorite-potassium bromide-sodium dodecyl betaine water dispersible granule comprises, by mass, 40-60 parts of sodium hypochlorite, 1-3 parts of potassium bromide, 0.2-1.0 part of dodecyl betaine, 0.2-0.4 part of sodium hydroxide and 40-60 parts of water.
2. A disinfectant as set forth in claim 1, wherein: the sodium hypochlorite-potassium bromide-sodium dodecyl betaine-sodium hypochlorite-potassium bromide-potassium dodecyl betaine-sodium hydroxide powder comprises, by mass, 40 parts of sodium hypochlorite, 1 part of potassium bromide, 0.2 part of dodecyl betaine, and 40 parts of water.
3. A disinfectant as set forth in claim 1, wherein: the sodium hypochlorite-potassium bromide-sodium dodecyl betaine-sodium hypochlorite-potassium bromide-sodium dodecyl betaine-sodium hydroxide powder comprises, by mass, 55 parts of sodium hypochlorite, 2 parts of potassium bromide, 0.6 part of dodecyl betaine, 0.35 part of sodium hydroxide and 55 parts of water.
4. A disinfectant as set forth in claim 1, wherein: the sodium hypochlorite-potassium bromide-sodium dodecyl betaine-sodium hypochlorite-potassium bromide-potassium dodecyl betaine-sodium hydroxide powder comprises, by mass, 60 parts of sodium hypochlorite, 3 parts of potassium bromide, 1.0 part of dodecyl betaine, 0.4 part of sodium hydroxide and 60 parts of water.
5. A method of preparing a disinfectant as claimed in any of claims 1 to 4, characterized in that: the method comprises the following steps:
step one, measuring the effective chlorine content of sodium hypochlorite, and calculating the adding amount of the sodium hypochlorite and purified water (the effective chlorine content is fed according to 4-7%);
step two, weighing the dodecyl betaine and the potassium bromide according to the formula, putting the dodecyl betaine and the potassium bromide into a stirring tank, adding 30-50% of purified water, and stirring to dissolve;
putting the calculated amount of sodium hypochlorite and the balance of purified water into a stirring tank, and uniformly stirring;
adding sodium hydroxide into a stirring tank, stirring and dissolving, and adjusting the pH value;
step five, carrying out semi-finished product inspection on the disinfectant prepared in the step four;
and step six, filling the semi-finished product qualified in the step four.
6. A disinfectant as set forth in claim 5, wherein: in the first step, the sodium hypochlorite meets the requirement of type A in GB 19106-.
7. A disinfectant as set forth in claim 6, wherein: in the second step, the dodecyl betaine meets the requirement of QB/T2344-; the potassium bromide should meet the requirements of HG/T3808-2006 industrial grade.
8. A disinfectant as set forth in claim 7, wherein: the sodium hypochlorite dosage in the third step is the dosage calculated in the first step; and the residual purified water is the calculated amount of the purified water in the step one minus the used amount of the purified water in the step two.
9. A disinfectant as set forth in claim 8, wherein: the sodium hydroxide in the fourth step meets the requirement of industrial grade IS-I in GB/T209-2018, and the pH IS adjusted to be 12-13 (detected by an acidimeter).
10. A disinfectant according to claim 9, wherein: in the sixth step, the filling specification is 500ml or 5L or 25L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110340555.0A CN113197218A (en) | 2021-03-30 | 2021-03-30 | Disinfectant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110340555.0A CN113197218A (en) | 2021-03-30 | 2021-03-30 | Disinfectant and preparation method thereof |
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| Publication Number | Publication Date |
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| CN113197218A true CN113197218A (en) | 2021-08-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110340555.0A Pending CN113197218A (en) | 2021-03-30 | 2021-03-30 | Disinfectant and preparation method thereof |
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1152398A (en) * | 1996-10-21 | 1997-06-25 | 谢体生 | Washing disinfactant |
| US20130217610A1 (en) * | 2012-02-17 | 2013-08-22 | The Clorox Company | Targeted performance of hypohalite methods thereof |
| CN107287061A (en) * | 2017-05-27 | 2017-10-24 | 山东瑞泰奇洗涤消毒科技有限公司 | A kind of cleaning and disinfecting liquid of aroma type 84 containing natural soap base and preparation method thereof |
| CN107484771A (en) * | 2017-09-30 | 2017-12-19 | 蚌埠科卫消毒药剂有限公司 | A kind of 84 thimerosals and preparation method thereof |
| CN109805009A (en) * | 2019-01-24 | 2019-05-28 | 北京日光旭升精细化工技术研究所 | A kind of chlorine-containing disinfectant and preparation method thereof |
| CN110591833A (en) * | 2019-10-09 | 2019-12-20 | 广州超威生物科技有限公司 | Toilet cleaning agent and preparation method thereof |
| CN111493088A (en) * | 2020-04-29 | 2020-08-07 | 广西夏阳环保科技有限公司 | Efficient composite 84 disinfectant and preparation method thereof |
| CN111990410A (en) * | 2020-09-03 | 2020-11-27 | 感控卫士(山东)医疗科技有限公司 | Hypochlorous acid disinfectant, preparation method thereof and preparation method of disinfectant wet tissue |
-
2021
- 2021-03-30 CN CN202110340555.0A patent/CN113197218A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1152398A (en) * | 1996-10-21 | 1997-06-25 | 谢体生 | Washing disinfactant |
| US20130217610A1 (en) * | 2012-02-17 | 2013-08-22 | The Clorox Company | Targeted performance of hypohalite methods thereof |
| CN107287061A (en) * | 2017-05-27 | 2017-10-24 | 山东瑞泰奇洗涤消毒科技有限公司 | A kind of cleaning and disinfecting liquid of aroma type 84 containing natural soap base and preparation method thereof |
| CN107484771A (en) * | 2017-09-30 | 2017-12-19 | 蚌埠科卫消毒药剂有限公司 | A kind of 84 thimerosals and preparation method thereof |
| CN109805009A (en) * | 2019-01-24 | 2019-05-28 | 北京日光旭升精细化工技术研究所 | A kind of chlorine-containing disinfectant and preparation method thereof |
| CN110591833A (en) * | 2019-10-09 | 2019-12-20 | 广州超威生物科技有限公司 | Toilet cleaning agent and preparation method thereof |
| CN111493088A (en) * | 2020-04-29 | 2020-08-07 | 广西夏阳环保科技有限公司 | Efficient composite 84 disinfectant and preparation method thereof |
| CN111990410A (en) * | 2020-09-03 | 2020-11-27 | 感控卫士(山东)医疗科技有限公司 | Hypochlorous acid disinfectant, preparation method thereof and preparation method of disinfectant wet tissue |
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