WO2020180101A3 - Pca 공정을 이용한 배양액의 결정화 장치 및 방법 - Google Patents

Pca 공정을 이용한 배양액의 결정화 장치 및 방법 Download PDF

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Publication number
WO2020180101A3
WO2020180101A3 PCT/KR2020/003048 KR2020003048W WO2020180101A3 WO 2020180101 A3 WO2020180101 A3 WO 2020180101A3 KR 2020003048 W KR2020003048 W KR 2020003048W WO 2020180101 A3 WO2020180101 A3 WO 2020180101A3
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WIPO (PCT)
Prior art keywords
solvent
culture solution
crystallizing
pressure container
container
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PCT/KR2020/003048
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English (en)
French (fr)
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WO2020180101A2 (ko
Inventor
이윤우
손원수
박희정
송순욱
김시나
이찬주
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서울대학교산학협력단
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Publication of WO2020180101A2 publication Critical patent/WO2020180101A2/ko
Publication of WO2020180101A3 publication Critical patent/WO2020180101A3/ko

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0278—Physical preservation processes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Environmental Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

PCA 공정을 이용한 배양액의 결정화 장치 및 방법이 제공된다. 상기 PCA 공정을 이용한 배양액의 결정화 방법은, 용기에 제1 용매 및 상기 제1 용매에 녹아있는 타겟 물질을 포함하는 배양액을 공급하는 단계, 상기 용기에 제3 용매를 공급하는 단계, 및 상기 용기에 제2 용매를 공급하는 단계를 포함한다. 상기 제1 내지 제3 용매는 다성분계 혼합물을 생성하고, 상기 타겟 물질은 석출된다. 상기 PCA 공정을 이용한 배양액의 결정화 장치는, 제1 용매 및 상기 제1 용매에 녹아있는 타겟 물질을 포함하는 배양액을 건조하여 상기 타겟 물질을 획득하기 위한 장치로서, 상기 배양액이 공급되는 고압 용기, 상기 고압 용기에 연결되어 상기 고압 용기에 제2 용매를 공급하는 제1 공급부, 상기 고압 용기에 연결되어 제3 용매를 공급하는 제2 공급부, 상기 제1 공급부에 인접하게 배치되어 상기 제1 공급부에서 배출되는 상기 제2 용매를 예냉하는 예냉기, 및 상기 고압 용기에 인접하게 배치되어 상기 고압 용기에 공급되는 상기 제2 용매를 예열하는 예열기를 포함한다.
PCT/KR2020/003048 2019-03-05 2020-03-04 Pca 공정을 이용한 배양액의 결정화 장치 및 방법 WO2020180101A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020190025419A KR102170146B1 (ko) 2019-03-05 2019-03-05 Pca 공정을 이용한 배양액의 결정화 장치 및 방법
KR10-2019-0025419 2019-03-05

Publications (2)

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WO2020180101A2 WO2020180101A2 (ko) 2020-09-10
WO2020180101A3 true WO2020180101A3 (ko) 2021-05-14

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PCT/KR2020/003048 WO2020180101A2 (ko) 2019-03-05 2020-03-04 Pca 공정을 이용한 배양액의 결정화 장치 및 방법

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KR (1) KR102170146B1 (ko)
WO (1) WO2020180101A2 (ko)

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US20240066069A1 (en) 2021-01-08 2024-02-29 Seoul National University R&Db Foundation Dried cell secretome-based therapeutic agent for osteoarthritis treatment

Citations (5)

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Publication number Priority date Publication date Assignee Title
US6838089B1 (en) * 1998-04-14 2005-01-04 Astrazeneca Ab Antigen delivery system and method of production
KR100600691B1 (ko) * 1998-04-14 2006-07-19 아스트라제네카 아베 활성 물질의 담체 매트릭스로의 결합
KR101107328B1 (ko) * 2002-11-29 2012-01-20 얀센 파마슈티카 엔.브이. 염기성/산성 약물 화합물, 계면활성제 및 생리학적으로용인되는 수용성 산/염기를 포함하는 약제학적 조성물
US9138705B2 (en) * 2010-11-22 2015-09-22 Hong Kong Polytechnic University Method for precipitating a solute from a solution
US9259396B2 (en) * 2012-01-20 2016-02-16 Nano And Advanced Materials Institute Limited Method of preparing soy isoflavone nanoparticles by precipitation with compressed antisolvent (PCA) using a supercritical fluid

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6838089B1 (en) * 1998-04-14 2005-01-04 Astrazeneca Ab Antigen delivery system and method of production
KR100600691B1 (ko) * 1998-04-14 2006-07-19 아스트라제네카 아베 활성 물질의 담체 매트릭스로의 결합
KR101107328B1 (ko) * 2002-11-29 2012-01-20 얀센 파마슈티카 엔.브이. 염기성/산성 약물 화합물, 계면활성제 및 생리학적으로용인되는 수용성 산/염기를 포함하는 약제학적 조성물
US9138705B2 (en) * 2010-11-22 2015-09-22 Hong Kong Polytechnic University Method for precipitating a solute from a solution
US9259396B2 (en) * 2012-01-20 2016-02-16 Nano And Advanced Materials Institute Limited Method of preparing soy isoflavone nanoparticles by precipitation with compressed antisolvent (PCA) using a supercritical fluid

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
FUSARO, F. ET AL.: "Compressed CO2 antisolvent precipitation of lysozyme", THE JOURNAL OF SUPERCRITICAL FLUIDS, vol. 49, 2009, pages 79 - 92, XP026048780, DOI: 10.1016/j.supflu.2008.12.005 *

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WO2020180101A2 (ko) 2020-09-10
KR20200106779A (ko) 2020-09-15
KR102170146B1 (ko) 2020-10-26

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