WO2020151125A1 - 微环境氢气供给透气层及外敷袋 - Google Patents

微环境氢气供给透气层及外敷袋 Download PDF

Info

Publication number
WO2020151125A1
WO2020151125A1 PCT/CN2019/085359 CN2019085359W WO2020151125A1 WO 2020151125 A1 WO2020151125 A1 WO 2020151125A1 CN 2019085359 W CN2019085359 W CN 2019085359W WO 2020151125 A1 WO2020151125 A1 WO 2020151125A1
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogen
peroxide
production formula
metal
thin layer
Prior art date
Application number
PCT/CN2019/085359
Other languages
English (en)
French (fr)
Inventor
曹荣华
王婷嬅
曹政中
曹家菱
曹家瑄
Original Assignee
曹荣华
王婷嬅
曹政中
曹家菱
曹家瑄
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 曹荣华, 王婷嬅, 曹政中, 曹家菱, 曹家瑄 filed Critical 曹荣华
Priority to SG11202107501RA priority Critical patent/SG11202107501RA/en
Priority to CA3126408A priority patent/CA3126408A1/en
Publication of WO2020151125A1 publication Critical patent/WO2020151125A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/30—Hydrogen technology
    • Y02E60/36—Hydrogen production from non-carbon containing sources, e.g. by water electrolysis

Definitions

  • This application provides a micro-environmental hydrogen supply gas permeable layer and external application bag containing a hydrogen production formula.
  • supplying hydrogen to the skin or inside the human body, it has the advantages of non-irritating, excellent diffusion ability, and no harmful by-products of the reaction.
  • Hydrogen (H 2 ) is a colorless and odorless gas.
  • Hydrogen can be used as an antioxidant gas to treat cancer.
  • Japanese scholars used hydrogen to neutralize toxic free radicals to treat cerebral ischemia reperfusion injury.
  • Hydrogen can selectively neutralize free radicals, produce anti-oxidation, anti-inflammatory and anti-apoptosis effects, without affecting the physiologically active reactive oxygen species in the body, such as superoxide anions and hydrogen peroxide, indicating that hydrogen can be used safely human body.
  • Another advantage of hydrogen is its strong diffusion ability. Cell membranes and various biological barriers do not affect the diffusion and penetration of hydrogen. It can reach any part of the body. It is considered to be common acute and chronic diseases such as stroke, diabetes, arteriosclerosis, and Parkinson's disease. The disease has a therapeutic effect.
  • Hydrogen can be used by inhaling hydrogen, drinking hydrogen water or injecting hydrogen brine. Inhalation of hydrogen gas can improve neurological and cardiovascular diseases such as stroke and myocardial infarction. Drinking hydrogen water has been reported to have therapeutic effects on diabetes and metabolic diseases. In addition, in animal models, it has also been proved that drinking hydrogen water can improve allergic diseases. Such as: atopic dermatitis; if it is injected directly into the retinopathy eyeball, it can treat fundus diseases.
  • the current common hydrogen supply methods include hydrogen water or high-pressure hydrogen tanks.
  • the hydrogen water fuses hydrogen into the water.
  • a hydrogen generator is required, which is large in size, consumes electricity, and the finished hydrogen water is difficult to store; if you want to add high purity
  • high-pressure hydrogen cylinders are usually used.
  • the potential safety risks of high-pressure gas cylinders also cause concerns in use. Because hydrogen generators and high-pressure hydrogen cylinders are inconvenient to carry, it is not easy to promote, and the practical application of hydrogen is restricted. Therefore, how to supply hydrogen that can be used anytime, anywhere and easily can easily solve non-bacterial inflammation and other health benefits. Apply for the problem to be solved.
  • the applicant in this case provides a micro-environment hydrogen supply gas-permeable layer and an external application bag, comprising: a thin layer enveloping a hydrogen production formula, and a plurality of small holes on the inner surface, wherein the outer side of the thin layer is not breathable, The inner side is breathable, and the inner surface has multiple small holes.
  • the thin layer can be a single layer or a composite layer; the hydrogen production formula is wrapped in the thin layer and will not escape, and will absorb moisture in the air or liquid water , And then generate hydrogen; the hydrogen is released into the skin and inside the human body through the multiple small holes.
  • the inner material of the thin layer can be silica gel, silica gel, non-woven fabric, or plastic breathable film.
  • the outer material of the thin layer is polypropylene, polyethylene plastic film, aluminum film, or composite film.
  • the hydrogen production formula may be in powder or granular form.
  • the hydrogen production formula includes metal peroxide, metal hydroxide, or metal hydride, and aluminum powder or silicon powder.
  • the weight ratio of metal peroxide or metal hydroxide to aluminum powder is 1:100-100:1.
  • the weight ratio of metal peroxide or metal hydroxide to aluminum powder is 1:10-10:1.
  • the metal peroxide is selected from the group consisting of calcium peroxide, magnesium peroxide, sodium peroxide, and potassium peroxide
  • the metal hydroxide is selected from the group consisting of calcium hydroxide , Magnesium hydroxide, sodium hydroxide, potassium hydroxide
  • the metal hydride is selected from the group consisting of magnesium hydride, calcium hydride, silicon hydride.
  • the hydrogen production formula can be added with a solid acid selected from the group consisting of solid citric acid, solid lactic acid, solid oxalic acid, solid hydrochloric acid, solid phytic acid and solid silicic acid.
  • the hydrogen production formula may further include a super absorbent polymer, an activator or a catalyst.
  • the thin layer may further include oxygen and active oxygen generating units.
  • the breathable layer can be used in daily hygiene products, which include eye masks, masks, face masks, facial masks, bras, breast stickers, galactorrhea stickers, sanitary napkins, sanitary napkins, diapers, sanitary care products Pads, wound dressings, band aids, dressing gauze, bedsore pads or external compress bags.
  • this application provides an external application bag for inhibiting inflammation, which contains:
  • the thin layer can be a single layer or a composite layer;
  • the hydrogen production formula which is wrapped in the thin layer, will not escape, and will absorb moisture or liquid water in the air to generate hydrogen gas; the hydrogen gas is released to the skin through the multiple small holes;
  • the oxygen-making formula is wrapped in the thin layer and will not escape, but will absorb moisture or liquid water in the air to generate oxygen; the oxygen is released to the skin through the plurality of small holes.
  • the inner material of the thin layer may be silica gel, silica gel, non-woven fabric, or plastic breathable film.
  • the outer material of the thin layer is polypropylene, polyethylene plastic film, aluminum film, or composite film.
  • the hydrogen production formula and the oxygen production formula can be in powder or granular form.
  • the hydrogen production formula includes metal peroxide, metal hydroxide, or metal hydride and aluminum powder or silicon powder.
  • the weight ratio of metal peroxide or metal hydroxide to aluminum powder is 1:100-100:1.
  • the weight ratio of metal peroxide or metal hydroxide to aluminum powder is 1:10-10:1.
  • the metal peroxide is selected from the group consisting of calcium peroxide, magnesium peroxide, sodium peroxide, and potassium peroxide.
  • the metal hydroxide is selected from the group consisting of calcium hydroxide, magnesium hydroxide, sodium hydroxide, and potassium hydroxide.
  • the metal hydride is selected from the group consisting of magnesium hydride, calcium hydride, and silicon hydride.
  • the hydrogen production formula can be added with a solid acid selected from the group consisting of solid citric acid, solid lactic acid, solid oxalic acid, solid hydrochloric acid, solid phytic acid and solid silicic acid, so that the pH of the hydrogen production formula Between 4-9.
  • the oxygen production formula is a metal peroxide, selected from the group consisting of calcium peroxide, magnesium peroxide, sodium peroxide, and potassium peroxide.
  • the weight ratio of the oxygen production formula to the hydrogen production formula is 1:1 to 1:50.
  • the inflammation refers to non-bacterial inflammation.
  • This application is an air permeable layer containing hydrogen production formula, which can generate a large amount of hydrogen in a short time and supply it to human skin, nostrils, mouth, eyes, or other parts of the human body that come into contact with it.
  • the beneficial effects are as follows:
  • This application further discloses that in order to obtain the best health effect of the breathable layer, the required hydrogen production formula, oxygen production formula ratio and dosage, and exemplifies that the breathable layer can be applied to household hygiene products, as well as the extended application of this application .
  • Figure 1 is a schematic diagram of a micro-environment hydrogen supply to the gas-permeable layer
  • Figure 2 is an exploded view of the breathable layer
  • Figure 3 is a cross-sectional view of the breathable layer
  • Figure 4 is a schematic diagram of the breathable layer applied to the eye mask
  • 5A and 5B are schematic diagrams of applying the breathable layer to a mask
  • Figure 6 is a schematic diagram of the breathable layer applied to a facial mask
  • Figure 7 is a schematic diagram of the air permeable layer applied to a wound dressing
  • Figure 8A shows the effect of the application for the external compress in the gout area that has not been used
  • Figure 8B shows the effect of using the external compress in this application for 2 hours on gout
  • Figure 8C shows the effect of using the external compress in this application for 3 hours on gout
  • Figure 8D shows the effect of using the external compress of this application for gout on the 4th day
  • Figure 9 is a schematic diagram of the external application bag applied to ankle pain
  • Fig. 10 is a schematic diagram of the application of the external compress bag to menstrual pain.
  • the present application provides a breathable layer 1, comprising: a thin layer 11 wrapped with a hydrogen production formula, wherein the outer side of the thin layer 11 is air-tight and the inner side is breathable, and the inner surface has a plurality of small holes 111 ,
  • the thin layer can be a single layer or a composite layer; and a hydrogen production formula 12, which is wrapped in the thin layer 11, will not escape, will absorb moisture in the air or liquid water, and then generate hydrogen; 2 It can be seen that the hydrogen gas will be absorbed into the human body through the multiple small holes 111 through the skin, nostrils, oral cavity, eyes, and other parts of the human body that come into contact with it.
  • the hydrogen production formula 12 is covered with the thin layer 11 which is airtight on the outside and air permeable on the inside.
  • the small holes 111 on the inside of the thin layer have a diameter smaller than the diameter of the hydrogen production formula 12 to ensure that the hydrogen production formula 12 does not For leakage, the outer side of the thin layer 11 is made of air-tight material, and the inner side is made of skin-friendly material.
  • the inner material of the thin layer 11 used to cover the hydrogen production formula 12 may be silica gel, non-woven fabric, or a plastic breathable film; the outer material may be polypropylene, polyethylene plastic film, aluminum film, or composite film.
  • the hydrogen production formula 12 may be in powder form or granular form, including metal peroxide, metal hydroxide, or metal hydride, and aluminum powder or silicon powder.
  • the metal peroxide is selected from the group consisting of calcium peroxide, magnesium peroxide, sodium peroxide, and potassium peroxide
  • the metal hydroxide is selected from the group consisting of calcium hydroxide, magnesium hydroxide, and hydroxide. The group consisting of sodium and potassium hydroxide.
  • the hydrogen production formula can also contain compounds that can generate metal hydroxides through water, such as magnesium hydride, calcium hydride, and silicon hydride.
  • the hydrogen production formula can optionally add a solid acid to neutralize the aforementioned hydrogen production formula, so that the pH of the hydrogen production formula is between 4-9 to avoid skin irritation and enhance the hydrogen absorption effect.
  • the solid acid is selected from the group consisting of solid citric acid, solid lactic acid, solid oxalic acid, solid hydrochloric acid, solid phytic acid, and solid silicic acid.
  • reaction formula is the mechanism for supplying hydrogen in the hydrogen production formula:
  • Metal hydroxide can react with aluminum powder to generate hydrogen, see the following reaction formula:
  • Metal hydrides can react with water to produce hydrogen and metal hydroxides, and metal hydroxides can react with water to continuously produce hydrogen.
  • the thin layer 11 can be further added with an oxygen-making formula 13, wherein the oxygen-making formula 13 can be in the form of powder or granules, including metal peroxide Material or metal superoxide.
  • the hydrogen generation efficiency of each reactant was tested in the range of 0.01-100 g.
  • the weight ratio of the formula to the hydrogen production formula is 1:1-1:50.
  • the breathable film can be used in daily hygiene products for personal use.
  • the daily hygiene products include but are not limited to eye masks (Figure 4), masks (Figure 5A, Figure 5B), face masks, masks ( Figure 6), bras, chest stickers, Galactorrhea patch, sanitary napkins, sanitary napkins, diapers, sanitary pads, wound dressings (Figure 7), band-aids, gauze, bedsore pads, and external dressing bags.
  • the following recruits subjects with various related diseases and symptoms, including neurological diseases, recent radiotherapy, constipation, UV damage, eye soreness, eye discomfort, and trauma, and assign the use of masks, eye masks, facial masks, Or household hygiene products such as wound dressings, continue to use for three months, three times a week, once for two hours, and fill out a questionnaire after the end, to investigate when the hydrogen production formula of the breathable layer is applied to various household hygiene products, the effect of each disease , The symptom improvement effect and the comfort level of use are based on 1-10 as the scoring benchmark. The higher the effect, the more significant the effect.
  • the test groups and results are shown in Table 1 below.
  • the metal peroxide is calcium peroxide and the metal hydroxide is calcium hydroxide, both of which are 10 grams, aluminum powder 1 gram, appropriate amount of citric acid, water through the skin or externally added Water to produce hydrogen.
  • Table 1- The effectiveness and comfort of the breathable layer in the mask for various diseases and symptoms
  • Embodiment two eye mask
  • the test groups and results are shown in Table 2 below.
  • the metal peroxide is sodium peroxide and the metal hydroxide is sodium hydroxide.
  • the hydrogen production formula in this case can improve eye soreness, eye diseases, etc., and it has better effects than commercially available eye masks or the group that does not contain aluminum powder (cannot generate hydrogen); in addition, each combination of this case All of them have better comfort than commercially available eye masks, and when peroxides, hydroxides, and solid acids are also available, the comfort is improved. If oxygen formula is added at the same time, a large amount of hydrogen and a large amount of oxygen are generated at the same time, which is more comfortable good. At the same time, adding oxygen formula can avoid the discomfort caused by the lack of oxygen due to the excessive contact time of the external application bag.
  • Table 2- The effect and comfort of the breathable layer in the eye mask for various diseases and symptoms
  • the test groups and results are shown in Table 3 below.
  • the metal peroxide is magnesium peroxide
  • the metal hydroxide is magnesium hydroxide, both of which are 12.5 grams, 6.25 grams of silica fume, and the appropriate amount of solid acid is lactic acid. Produce hydrogen.
  • the hydrogen production formula in this case has the effects of improving UV damage, radiotherapy side effects, and neurological diseases; in addition, all combinations in this case It has better comfort than commercially available masks, and if it contains peroxides, hydroxides, and solid acids, the comfort is better.
  • Table 3- The effectiveness and comfort of the breathable layer in the mask for various diseases and symptoms
  • the test groups and results are shown in Table 4 below.
  • the metal peroxide is potassium peroxide and the metal hydroxide is potassium hydroxide, both are 2.5 grams, aluminum powder is 2.5 grams, and the solid acid is phytic acid.
  • Wound dressings can be used Hydrogen is produced by absorbing water, which can keep the water from being released back to the wound, and through the air-permeable layer, the design is only for gas circulation, so as to obtain the improved effect of supplying hydrogen and avoiding secondary infection of the wound.
  • this external dressing bag is added with oxygen-making material-peroxide to generate more oxygen; the wound dressing can generate hydrogen and oxygen by absorbing water, and it is more effective It is designed to keep water from being released to the wound in the reverse direction, and through the air-permeable layer only for gas circulation, to obtain hydrogen supply and at the same time avoid skin and wound discomfort caused by hypoxia.
  • FIG. 8A A 55-year-old male tester had a gout attack, his right thumb was red and swollen, and there was severe pain (Fig. 8A). Spray the external application bag on the red and swollen area. After one hour, the pain was significantly reduced. Change the external application bag every hour. 8B is the effect after using the second external application bag, Figure 8C is the effect of using the third external application bag to reduce the swelling of the gout area by about 40%. 3 external application bags are used every day, after 10 tablets (day 4) gout The swelling was obviously reduced (Figure 8D), and there was no discomfort caused by allergies caused by the external application bag contacting the skin.
  • the external application bag contains 2.5 grams of calcium peroxide and 1.5 grams of aluminum powder, which can generate a large amount of hydrogen and a large amount of oxygen.
  • Example 5-2 Ankle pain
  • a 60-year-old male tester had cervical spine pain for more than 20 years. After spraying the external application bag on the cervical spine, the pain was significantly reduced after 30 minutes, and there was no discomfort such as allergies caused by the external application bag contacting the skin.
  • Example 5-4 Breast pain before menstruation
  • the 21-year-old female tester had premenstrual symptoms, such as breast tenderness before menstruation.
  • breast tenderness and pain before menstruation apply this external compress bag to the front of the breast.
  • the external application bag contains 2.5 grams of calcium peroxide and 1.5 grams of aluminum powder, which can generate a large amount of hydrogen and a large amount of oxygen.
  • Example 5-5 Physiological pain
  • a 30-year-old female tester who has endometriosis will experience physical pain during her menstrual period.
  • menstrual period When the menstrual period is painful, apply this external compress bag to the position around the navel (as shown in Figure 10). After 10 minutes, the pain is significantly reduced.
  • the external application bag contains 1 gram of peroxide, 1.5 grams of potassium hydroxide, 1.5 grams of aluminum powder, and appropriate amount of phytic acid, which can generate a large amount of hydrogen and a large amount of oxygen.
  • the 55-year-old male tester had long-term hip pain. He sprayed the external application bag on the hip pain area. After 20 minutes, the pain was significantly reduced and there was no discomfort caused by the external application bag contacting the skin.
  • high-molecular water-absorbing materials ie super absorbent polymers
  • super absorbent polymers can also be added at the same time to absorb liquids, so as to simultaneously generate hydrogen and avoid liquid backflow. Double effect of skin infection and inflammation.
  • the breathable layer and external application bag of the present application no matter what combination of hydrogen production formula, can improve neurological diseases, radiotherapy side effects, constipation, ultraviolet light damage, eye soreness, Eye discomfort and wound healing.
  • the antioxidant effect of hydrogen and the effect of improving the flora in the body it breaks through the functional scope of the previous sanitary products.
  • this case system Compared with the group that only generates hydrogen (without aluminum powder), this case system
  • the application of hydrogen formula can achieve more excellent, wide-ranging and diversified body health effects, and has beneficial effects; and because of the relationship that it can generate oxygen at the same time, it has better comfort than commercial products (without gas-producing formula), and no gas
  • the feeling of stuffiness improves the comfort of use; when peroxide, hydroxide and solid acid are added at the same time, the best effect of improving diseases, symptoms, and comfort will be achieved.
  • this case can produce a large amount of hydrogen and oxygen in a short period of time, which can be supplied to human skin, nostrils, mouth, eyes, or other parts of the human body that come into contact with it.
  • it does not require steel cylinders.
  • the advantages of pipeline, manufacturing machine or plug-in are easy to carry around, the formula is harmless, can be used close to the skin, and the hydrogen generation is simple and does not cause harmful by-products and other optimization effects.
  • the simple structure of hydrogen is also used, so it has excellent diffusion ability, and the reaching position is not restricted. It is a non-toxic, mild and safe reducing agent. It has excellent effects of removing free radicals and improving the flora in the body. Compared with the past At the health-care level of the existing sanitary products, it has achieved more extensive and increased efficacy benefits.
  • the diseases listed in this application are the elimination of free radicals through hydrogen gas.
  • the corresponding disease applications With the examples of this case, the breathable layer of this case can be reasonably applied to alleviate any other diseases originating from these two causes, such as: Cancer, side effects of chemotherapy, metabolic diseases, immune diseases, allergies, diabetes, weight control, colitis or other non-bacterial inflammations, etc.
  • the hydrogen production formula may further include super absorbent polymers, activators or catalysts as appropriate; in addition, it is also possible to further add generating units that can generate oxygen and active oxygen, and adjust the ratio to correspond to Different needs to achieve the desired effect.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Materials Engineering (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

一种微环境氢气供给透气层（1）及外敷袋，包含：一薄层（11），包裹一制氢配方（12），其中，该薄层（11）外侧不透气，内侧透气，内侧表面具多个小孔洞（111），该薄层（11）可为单层或是复合层。制氢配方（12）被包裹于该薄层（11）中，不会逸散，会吸收空气中水分或是液态水，进而生成氢气。该氢气通过该多个小孔洞（111）释放至皮肤、人体内部。其中，该制氢配方（12）系包含金属过氧化物、金属氢氧化物、或金属氢化物及铝粉或硅粉；该透气层（1）可以用于外敷袋或其他生活卫生用品中，具有改善非细菌性发炎及其他保健的功效。

Description

微环境氢气供给透气层及外敷袋
本申请要求提交国际局、申请日为2019年01月25日、申请号为PCT/CN2019/073210、申请名称为“微环境氢气供给透气层”的国际专利申请的优先权，其全部内容通过引用结合在本申请中。
技术领域
本申请提供一包含制氢配方的微环境氢气供给透气层及外敷袋，透过供给氢气至皮肤或是人体内部，以氢气的不具刺激性、优异扩散能力、与反应不具有害副产物等优势，达到保健、疾病改善的用途，属于生活保健领域。
背景技术
氢气(H 2)是一种无色无味的气体，1975年有研究报导指出，氢气可以作为抗氧化气体治疗癌症，2007年日本学者以氢气中和有毒自由基，治疗脑缺血再灌注损伤，其后有大量研究确认氢气对多种疾病和损伤有治疗效果。氢气能选择性中和自由基，产生抗氧化、抗炎症和抗细胞凋亡等效应，而不影响体内具有生理作用的活性氧，如：超氧阴离子和过氧化氢等，说明氢气安全可用于人体。氢气的另外一个优点是具有强大的扩散能力，细胞膜和各种生物屏障都不影响氢气的扩散渗透，能达到身体任何部位，被认为对中风、糖尿病、动脉硬化、帕金森病等常见急性和慢性疾病具有治疗作用。
氢气的使用可以通过吸入氢气、饮用氢水或注射氢气盐水等方法。吸入氢气对中风、心肌梗塞等具有神经、心血管疾病具有改善作用，饮用氢水被报导对糖尿病和代谢疾病有治疗效果；另外，在动物模式中，也证明饮用氢水可改善过敏性疾病，如：异位性皮肤炎；若是直接注射于视网膜病变眼球内，则可治疗眼底疾病。日本鹿儿岛大学和印度尼西亚Sam Ratulangi大学合作，采用高浓度氢水合并使用抗癌药5氟尿嘧啶，利用细胞学和动物模型两种模式，证明氢气不仅能促进肿瘤细胞凋亡，且可以明显增加5氟尿嘧啶的 抗肿瘤效果，延长患有肿瘤的动物寿命。
目前常见的氢气供给方式，包括氢水或高压氢气罐，氢水将氢气融合于水中，首先需要氢气制造机，体积大、需要耗电，且制作完成的氢水不易保存；若要补充高纯度的氢气，通常会使用高压氢气钢瓶，但除了体积、重量造成的不便携带问题外，高压气体钢瓶具有的潜在安全风险，也令使用上有所顾虑。由于氢气制造机与高压氢气钢瓶携带不便，推广并不容易，使氢气在实际应用上受到限制，因此如何供应可随时随地、便于使用的氢气可以容易的解决非细菌性发炎及其他保健功效是本申请要解决的问题。
市面上有各式贴身接触皮肤的生活卫生用品(包含口罩、面罩、面膜等)，由于与皮肤直接接触，因此，常标榜穿戴之舒适性与方便性，然而，近年来，该领域者也针对其他可合并达成功效，力求改良与突破，例如透过内部材料反应，供给人体氧气等有益气体；然而，由于气体供给来自于材料间内部化学作用，若为了提升保健功效，往往须涵括更多材料或同时包含更多种类的材料组合，进而衍生材料逸散或不安全副产物的风险。
因此，如何以提供一可供给氢气的透气层在生活卫生用品中，为本申请在此欲解决的一重要问题。
发明内容
为解决前述问题，本案申请人提供一种微环境氢气供给透气层及外敷袋，包含：一薄层，包裹一制氢配方，内侧表面具多个小孔洞，其中，该薄层外侧不透气，内侧透气，内侧表面具多个小孔洞，该薄层可为单层或是复合层；该制氢配方，被包裹于该薄层中，不会逸散，会吸收空气中水分或是液态水，进而生成氢气；该氢气通过该多个小孔洞释放至皮肤、人体内部。
进一步的技术方案中，该薄层的内侧材质可为硅胶、硅胶、无纺布、或塑料透气膜。
进一步的技术方案中，其中该薄层的外侧材质为聚丙烯、聚乙烯塑料薄膜、铝膜、或复合膜。
进一步的技术方案中，其中该制氢配方可为粉末状、颗粒状。
进一步的技术方案中，其中该制氢配方包含金属过氧化物、金属氢氧化物、或金属氢化物及铝粉或硅粉。
进一步的技术方案中，金属过氧化物或金属氢氧化物与铝粉的重量比例为：1:100-100:1。
进一步的技术方案中，金属过氧化物或金属氢氧化物与铝粉的重量比例为：1:10-10:1。
可选的技术方案中，其中该金属过氧化物选自于由过氧化钙、过氧化镁、过氧化钠、过氧化钾所组成的群组；该金属氢氧化物选自于由氢氧化钙、氢氧化镁、氢氧化钠、氢氧化钾所组成的群组；该金属氢化物选自于由氢化镁、氢化钙、氢化硅所组成的群组。
为达本案申请目的，其中该制氢配方可添加一固体酸，该固体酸选自于由固体柠檬酸、固体乳酸、固体草酸、固体盐酸、固体植酸和固体硅酸所组成的群组。
可选的技术方案中，该制氢配方可进一步包含高吸水性聚合物、活化剂或是催化剂。
可选的技术方案中，该薄层可进一步包含氧气及活性氧生成单元。
可选的技术方案中，该透气层可以用于生活卫生用品中，该生活卫生用品是包含眼罩、口罩、面罩、面膜、胸罩、胸贴、溢乳贴、卫生棉、卫生巾、纸尿裤、卫生护垫、伤口敷料、创可贴、包扎纱布、褥疮垫或外敷袋。
基于相同的申请构思，本申请提供一种抑制发炎的外敷袋，包含：
一薄层，包裹一制氢配方、一制氧配方，其中，该薄层外侧不透气，内侧透气，内侧表面具多个小孔洞，该薄层可为单层或是复合层；
该制氢配方，被包裹于该薄层中，不会逸散，会吸收空气中水分或是液态水，进而生成氢气；该氢气通过该多个小孔洞释放至皮肤；
该制氧配方，被包裹于该薄层中，不会逸散，会吸收空气中水分或是液态水，进而生成氧气；该氧气通过该多个小孔洞释放至皮肤。
进一步的技术方案中，其中该薄层的内侧材质可为硅胶、硅胶、无纺布、或塑料透气膜。
进一步的技术方案中，其中该薄层的外侧材质为聚丙烯、聚乙烯塑料薄膜、铝膜、或复合膜。其中该制氢配方、该制氧配方可为粉末状、颗粒状。
为达本案申请目的，其中该制氢配方包含金属过氧化物、金属氢氧化物、或金属氢化物及铝粉或硅粉。
进一步的技术方案中，金属过氧化物或金属氢氧化物与铝粉的重量比例为：1:100-100:1。
进一步的技术方案中，金属过氧化物或金属氢氧化物与铝粉的重量比例为：1:10-10:1。
可选的技术方案中，其中该金属过氧化物选自于由过氧化钙、过氧化镁、过氧化钠、过氧化钾所组成的群组。
可选的技术方案中，其中该金属氢氧化物选自于由氢氧化钙、氢氧化镁、氢氧化钠、氢氧化钾所组成的群组。
可选的技术方案中，其中该金属氢化物选自于由氢化镁、氢化钙、氢化硅所组成的群组。该制氢配方可添加一固体酸，该固体酸选自于由固体柠檬酸、固体乳酸、固体草酸、固体盐酸、固体植酸和固体硅酸所组成的群组，使该制氢配方的酸碱度介于4-9之间。
可选的技术方案中，该制氧配方是金属过氧化物，选自于由过氧化钙、过氧化镁、过氧化钠、过氧化钾所组成的群组。
可选的技术方案中，该制氧配方与该制氢配方的重量比例为1:1-1:50。
具体的技术方案中，该发炎是指非细菌性发炎。
本申请为内含制氢配方的透气层，可于短时间内，产生大量氢气，供给人体皮肤、鼻孔、口腔、眼睛、或是其他接触的人体部位，有利功效如下所示：
(1)使用安全方便，不须钢瓶管线或插电，便于随身携带，且配方无害，可贴身使用。
(2)不会衍生有害副产物。
(3)贴近皮肤易于吸收。
(4)氢气的广泛身体保健用途：
-优异的扩散能力，抵达部位不受限制；
-无毒、温和的安全还原剂；
-可以中和自由基，具优异抗氧化、抗发炎效果，尤其是针对非细菌性发炎；
-改善体内菌群。
(5)氧气添加更一步改善过去传统敷料因为长期使用造成缺氧的问题。
本申请进一步的揭示，为取得透气层最佳保健效果，所需的较佳制氢配方、制氧配方比例与剂量，并例示可将透气层施用于生活卫生用品中，以及本申请的延伸应用。
附图说明
为了更清楚地说明本公开实施例或相关技术中的技术方案，下面将对实施例或相关技术描述中所需要使用的附图作一简单地介绍，显而易见地，下面描述中的附图是本公开的一些实施例，对于本领域普通技术人员来讲，在不付出创造性劳动的前提下，还可以根据这些附图获得其他的附图。
图1为一微环境氢气供给透气层的示意图；
图2为该透气层的分解图；
图3为该透气层的剖面图；
图4为该透气层应用于眼罩的示意图；
图5A、图5B为该透气层应用于口罩的示意图；
图6为该透气层应用于面膜的示意图；
图7为该透气层应用于伤口敷料的示意图；
图8A为痛风处尚未使用本申请中外敷袋的效果；
图8B为痛风处使用本申请中外敷袋2小时的效果；
图8C为痛风处使用本申请中外敷袋3小时的效果；
图8D为痛风处使用本申请中外敷袋第4天之效果；
图9为该外敷袋应用于脚踝疼痛的示意图；
图10为该外敷袋应用于生理痛的示意图。
附图标记：
1-透气层；
11-薄层；
111-小孔洞；
12-制氢配方。
具体实施方式
本申请是以下面的实施例予以示范阐明，但本申请不受下述实施例所限制，以下具体说明本案的微环境氢气供给透气层及外敷袋所涵括的特征、应用与优势，然而，凡未脱离本申请技艺精神所为的等效实施或变更，均应包含于本案的专利范围中。
如图1至图3所示，本申请提供一透气层1，包含：一薄层11，包裹一制氢配方，其中，该薄层11外侧不透气内侧透气，内侧表面具多个小孔洞111，该薄层可为单层或是复合层；以及一制氢配方12，被包裹于该薄层11中，不会逸散，会吸收空气中水分或是液态水，进而生成氢气；由图2可见，该氢气将通过该多个小孔洞111经由皮肤、鼻孔、口腔、眼睛、其他接触的人体部位，吸收入人体内部。
本申请将制氢配方12以外侧不透气，而内侧透气之该薄层11包覆，其中，该薄层内侧之小孔洞111孔径小于该制氢配方12直径，以保证该制氢配方12不外泄，该薄层11的外侧为不透气材质，内侧则为亲肤性材料。
在保存时，以气密材料包装，以保证空气中水分不会提前与该制氢配方12反应；使用时将气密包装撕除，应用在所需位置；使用该透气层1，可透过外侧不透气材质截留汗水、湿气等水份不外泄，因此，可充分令该制氢配 方12反应，并定向针对皮肤供给氢气。
用于包覆该制氢配方12的该薄层11的内侧材质，可为硅胶、无纺布、或塑料透气膜；外侧材质可为聚丙烯、聚乙烯塑料薄膜、铝膜、或复合膜。
该制氢配方12，可为粉末状、颗粒状，包含金属过氧化物、金属氢氧化物、或金属氢化物及铝粉或硅粉。
其中该金属过氧化物选自于由过氧化钙、过氧化镁、过氧化钠、过氧化钾所组成的群组，该金属氢氧化物选自于由氢氧化钙、氢氧化镁、氢氧化钠、氢氧化钾所组成的群组。
该制氢配方亦可包含可透过水分生成金属氢氧化物之化合物，例如：氢化镁、氢化钙、氢化硅。
该制氢配方可选择性添加一固体酸，与前述制氢配方起中和作用，令制氢配方的酸碱值介于4-9之间，以避免刺激皮肤，并提升氢气吸收效果，该固体酸选自于由固体柠檬酸、固体乳酸、固体草酸、固体盐酸、固体植酸和固体硅酸所组成的群组。
以下反应式为制氢配方供给氢气的机制：
若为金属过氧化物，首先会透过与水反应，生成金属氢氧化物，并释放氧气，反应式为：
2XO 2+2H 2O→2X(OH) 2+O 2(X为钙、镁)或是
2Y 2O 2+2H 2O→4Y(OH)+O 2(X为钠、钾)
金属氢氧化物可与铝粉反应，生成氢气，见下列反应式：
2Al+2H 2O+X(OH) 2＝X(AlO 2) 2+3H 2
2Al+2H 2O+2Y(OH)＝2YAlO 2+3H 2
金属氢化物则可透过与水分反应，生成氢气及金属氢氧化物，金属氢氧化物可再与水反应，持续产生氢气。
前述反应中，若欲快速生成较大量氢气，可选择活性较大的碱金属(IA族)(亦即钠或钾)的过氧化物或是氢氧化物作为反应物。
透过前述例示制氢配方的组合应用，该领域具有通常技术者亦可联想应 用硅与氢氧化物及水反应，产生氢气，此为本案组合的等效实施，应包含于本案制氢配方之申请专利范围之内，其反应式如下：
Si+4H 2O＝H 4SiO 4+2H 2
H 4SiO 4+2NaOH＝Na 2SiO 3+3H 2
为避免敷料接触皮肤时间长，因为外侧不透气而缺氧引起的不适，该薄层11可进一步加入一制氧配方13，其中该制氧配方13可为粉末状、颗粒状，包含金属过氧化物或金属超氧化物。
金属过氧化物，会透过与水反应，并释放氧气，反应式为：
2XO 2+2H 2O→2X(OH) 2+O 2(X为钙、镁)或是
2Y 2O 2+2H 2O→4Y(OH)+O 2(X为钠、钾)
为获取较佳剂量比例，因此，测试各反应物分别于0.01-100克的范围时的氢气生成效率，前述该制氢配方在重量比例为金属过氧化物或金属氢氧化物：铝粉＝1:100-100:1时，可反应产生氢气，而当重量比例为1:10-10:1时，具有较优的氢气生成效率，若需要进一步产生氧气溢出至薄层1外，该制氧配方与该制氢配方的重量比例为1:1-1:50。
该透气膜可应用于生活卫生用品中，贴身使用，该生活卫生用品包括但不限于眼罩(图4)、口罩(图5A、图5B)、面罩、面膜(图6)、胸罩、胸贴、溢乳贴、卫生棉、卫生巾、纸尿裤、卫生护垫、伤口敷料(图7)、创可贴、包扎纱布、褥疮垫、外敷袋。
以下招募具有各相关疾病、症状的受试者，包含神经疾病、近期经过放射性疗法、便秘、紫外线损伤、眼部酸涩、眼部不适和外伤，分配使用含该透气膜的口罩、眼罩、面膜、或是伤口敷料等生活卫生用品，持续使用三个月，一周三次，一次两个小时，并于结束后填写问卷，调查当该透气层的制氢配方应用在各生活卫生用品时，对于各疾病、症状的改善功效及其使用上的舒适度，以1-10作为评分基准，越高表示成效越显着；同时，与市售不含产气材料的一般产品(以下简称市售)及不含铝粉之组别(不产生氢气)做对照，各评分统计之平均结果分述于下；该透气膜中的制氢配方根据上述之较 佳比例(金属过氧化物或金属氢氧化物：铝粉＝100:80-120)，并依所对应的生活卫生用品调整含量。
实施例一、口罩
测试组别及结果见下表1，金属过氧化物为过氧化钙、金属氢氧化物为氢氧化钙，均为10克，铝粉1克，柠檬酸适量，透过皮肤水份或是外加水，以产生氢气。
结果显示本案制氢配方可改善神经疾病、放射性疗法副作用、便秘等疾病/症状，此些功效不论是市售口罩，或是仅生成氧气(不含铝粉)的组别，均无法达成；另外，本案各组合均具较市售口罩更佳的舒适度，而在同时具有过氧化物、氢氧化物、固体酸时，舒适度较佳。
表1-口罩中的透气层对于各疾病、症状的改善功效及舒适度
Figure PCTCN2019085359-appb-000001
实施例二、眼罩
测试组别及结果见下表2，金属过氧化物为过氧化钠、金属氢氧化物为氢氧化钠，使用1～10克，铝粉10克，草酸适量，透过外加水，以产生氢气。
结果显示本案制氢配方可改善眼部酸涩、眼部疾病等，相较于市售眼罩，或是不含铝粉(无法生成氢气)的组别，均有更佳效果；另外，本案各组合均具较市售眼罩更佳的舒适度，而在同时具有过氧化物、氢氧化物、固体酸时，舒适度提升、若同时加入制氧配方，同时生成大量氢气与大量氧气，舒适度较佳。同时加入制氧配方，更可以避免外敷袋接触时间过长，因为缺氧引起的不适。
表2-眼罩中的透气层对于各疾病、症状的改善功效及舒适度
Figure PCTCN2019085359-appb-000002
实施例三、面膜
测试组别及结果见下表3，金属过氧化物为过氧化镁、金属氢氧化物为氢氧化镁，均为12.5克，硅粉6.25克，固体酸为乳酸适量，透过外加水，以产生氢气。
结果显示，相较于市售面膜，或是不含铝粉(无法生成氢气)之组别，本案制氢配方具有可改善紫外线损伤、放射性疗法副作用、神经疾病等功效；另外，本案各组合均具较市售面膜更佳的舒适度，而若同时具有过氧化物、氢氧化物、固体酸时，舒适度较佳。
表3-面膜中的透气层对于各疾病、症状的改善功效及舒适度
Figure PCTCN2019085359-appb-000003
实施例四、伤口敷料
测试组别及结果见下表4，金属过氧化物为过氧化钾、金属氢氧化物为氢氧化钾，均为2.5克，铝粉2.5克，固体酸为植酸适量；伤口敷料可藉由吸收水份产生氢气，更可保持水份不反向释出至伤口，并透过该透气层仅供气体流通的设计，而取得供给氢气并同时避免伤口二度感染的改良效果。
结果显示，相较于市售伤口敷料，或是不含铝粉(无法生成氢气)之组别，本案制氢配方具有可改善紫外线损伤、放射性疗法副作用、伤口愈合等功效；另外，本案各组合均具较市售敷料更佳之舒适度，而若同时具有过氧化物、氢氧化物、固体酸时，舒适度较佳。
表4-伤口敷料中的透气层对各疾病、症状的改善功效及舒适度
Figure PCTCN2019085359-appb-000004
Figure PCTCN2019085359-appb-000005
实施例五、外敷袋
为避免外敷袋接触皮肤时间长，因为缺氧引起的不适，本外敷袋额外增加制氧材料-过氧化物，以生成更多氧气；伤口敷料可借由吸收水份产生氢气、氧气，更可保持水份不反向释出至伤口，并透过该透气层仅供气体流通的设计，而取得供给氢气并同时避免皮肤及伤口因缺氧造成的不适。
实施例五-1、痛风
55岁男性测试者痛风发作，右脚大拇指红肿，并且有严重疼痛(图8A)，将本外敷袋喷水贴于红肿处，一小时后疼痛明显减轻，每一小时换一外敷袋，图8B为使用第二个外敷袋后的效果，图8C为使用第3个外敷袋后痛风处消肿约40％的效果，每天使用3个外敷袋，在使用10片后(第4天)痛风处明显消肿(图8D)，且没有产生因外敷袋接触皮肤造成过敏等不舒服。本外敷袋含过氧化钙2.5克、铝粉1.5克，可以生成大量氢气与大量氧气。
实施例五-2、脚踝疼痛
65岁男性测试者脚踝扭伤而疼痛，走路时疼痛更严重，疼痛难行，在扭伤4天后使用本外敷袋，将本外敷袋喷水贴于脚踝疼痛处(如图9)，10分钟后疼痛明显减轻了约一半，20分钟后疼痛明显减轻了约70％，1小时后不感觉疼痛且可以正常走路，外敷后没有产生因外敷袋接触皮肤造成过敏等不舒服。
实施例五-3、颈椎疼痛
60岁男性测试者有颈椎疼痛困扰超过20年，将本外敷袋喷水贴于颈椎处，30分钟后，疼痛明显减轻，且没有产生因外敷袋接触皮肤造成过敏等不舒服。
实施例五-4、经期前乳房胀痛
21岁女性测试者有经前症候群，如经期前乳房胀痛等。在经前乳房胀痛时，将本外敷袋喷水贴于乳房前，一小时后，疼痛明显减轻，且没有产生因外敷袋接触皮肤造成过敏等不舒服。本外敷袋含过氧化钙2.5克、铝粉1.5克，可以生成大量氢气与大量氧气。
实施例五-5、生理痛
30岁女性测试者，有子宫内膜异位，生理期时都会有生理痛的状况。在生理期疼痛时，将本外敷袋喷水贴于肚脐四周位置(如图10)，10分钟后，疼痛明显减轻，持续使用敷料3天、每天8小时，没有产生因敷料接触皮肤造成过敏等不舒服。本外敷袋含过氧化物为过氧化镁1克、氢氧化物为氢氧化钾1.5克、铝粉1.5克、植酸适量，可以生成大量氢气与大量氧气。
实施例五-6、髋骨疼痛
55岁男性测试者长期有髋骨疼痛困扰，将本外敷袋喷水贴于髋骨疼痛处，20分钟后，疼痛明显减轻，且没有产生因外敷袋接触皮肤造成过敏等不舒服。
结果显示，相较于市售外敷袋，外用本案制氢配方与制氧配方的组合可有效改善肌肉、骨骼、内脏的深度发炎与疼痛，且因为供给氧气没有产生因外敷袋接触皮肤造成过敏等不舒服。
另外，当使用卫生棉和卫生巾等特别具有液体不漏出之需求时，亦可同时添加高分子吸水材料(即高吸水性聚合物)，吸收液体，达到同时供氢气产生，并避免液体回流造成皮肤感染、发炎的双重功效。
总结而言，本申请的透气层及外敷袋，不论是何种制氢配方的组合，当应用在生活卫生用品中，均可改善神经疾病、放射性疗法副作用、便秘、紫外线损伤、眼部酸涩、眼部不适、伤口愈合，借由氢气的抗氧化功效及改善体内菌群的效果，一举突破以往生活卫生用品限制的功能范畴；相对于仅生 成氢气(不含铝粉)的组别，本案制氢配方的应用，可达成更优异、广泛多元的身体保健功效，具有利功效；并因同时可生成氧气的关系，较市售(不含产气配方)具有较佳舒适性，不会有气闷的感受，提升使用上的舒适性；当同时添加过氧化物、氢氧化物及固体酸时，会达成最佳改善疾病、症状、以及舒适度的效果。
综合而言，本案可于短时间内，产生大量氢气、氧气，供给人体皮肤、鼻孔、口腔、眼睛、或是其他接触的人体部位，相较于一般产生氢气的方法及器具，具有不须钢瓶管线、制造机或插电的优点，便于随身携带，配方无害，可贴近皮肤使用，且氢气的生成简便不会衍生有害副产物等优化效果。
此外，也应用氢气结构简单，故具有优异的扩散能力，抵达部位不受限制，为无毒、温和的安全还原剂，具优异交除自由基效果、改善体内菌群等优势，相较于以往的现有生活卫生用品的保健用途层面，取得更为广泛且功效提升的效益。
本申请列举之疾病，是透过氢气的消除自由基，所对应的疾病应用，借由本案实施例，可合理将本案的透气层应用于可改善任何源于此二成因的其他疾病，例如：癌症、化学疗法副作用、代谢疾病、免疫疾病、过敏、糖尿病、控制体重、结肠炎或其他非细菌性引起之发炎等。
为提升氢气生成效果，该制氢配方可视情况进一步包含高吸水性聚合物、活化剂或是催化剂；此外，亦可进一步添加可产生氧气及活性氧的生成单元，并进行比例的调整，对应不同需求，达成所需功效。
上列详细说明是针对本申请之可行实施例之具体说明，惟该实施例并非用以限制本申请之专利范围，凡未脱离本申请技艺精神所为之等效实施或变更，均应包含于本案之专利范围中。
显然，本领域的技术人员可以对本申请实施例进行各种改动和变型而不脱离本申请的精神和范围。这样，倘若本申请的这些修改和变型属于本申请权利要求及其等同技术的范围的内，则本申请也意图包含这些改动和变型在内。

Claims (28)

  1. 一种微环境氢气供给透气层，其特征在于，包含：
    一薄层，包裹一制氢配方，所述薄层外侧不透气，内侧透气，内侧表面具多个小孔洞，所述薄层包括单层或是复合层；
    所述制氢配方被包裹于所述薄层中，吸收空气中水分或是液态水，进而生成氢气；
    所述氢气通过所述多个小孔洞释放至皮肤、人体内部。
  2. 如权利要求1所述的微环境氢气供给透气层，其特征在于，所述薄层的内侧材质可为硅胶、无纺布、或塑料透气膜。
  3. 如权利要求1所述的微环境氢气供给透气层，其特征在于，所述薄层的外侧材质为聚丙烯、聚乙烯塑料薄膜、铝膜或复合膜。
  4. 如权利要求1所述的微环境氢气供给透气层，其特征在于，所述制氢配方包括粉末状或颗粒状。
  5. 如权利要求1所述的微环境氢气供给透气层，其特征在于，所述制氢配方包含金属过氧化物、金属氢氧化物、金属氢化物、铝粉或硅粉。
  6. 如权利要求5所述的微环境氢气供给透气层，其特征在于，金属过氧化物或金属氢氧化物与铝粉的重量比例为：1:100～100:1。
  7. 如权利要求6所述的微环境氢气供给透气层，其特征在于，金属过氧化物或金属氢氧化物与铝粉的重量比例为：1:10～10:1。
  8. 如权利要求5所述的微环境氢气供给透气层，其特征在于，所述金属过氧化物选自于由过氧化钙、过氧化镁、过氧化钠、过氧化钾所组成的群组。
  9. 如权利要求5所述的微环境氢气供给透气层，其特征在于，所述金属氢氧化物选自于由氢氧化钙、氢氧化镁、氢氧化钠、氢氧化钾所组成的群组。
  10. 如权利要求5所述的微环境氢气供给透气层，其特征在于，所述金属氢化物选自于由氢化镁、氢化钙、氢化硅所组成的群组。
  11. 如权利要求5所述的微环境氢气供给透气层，其特征在于，所述制 氢配方可添加一固体酸，所述固体酸选自于由固体柠檬酸、固体乳酸、固体草酸、固体盐酸、固体植酸和固体硅酸所组成的群组，使制氢配方的酸碱度介于4-9之间。
  12. 如权利要求1所述的微环境氢气供给透气层，其特征在于，所述制氢配方可进一步包含高吸水性聚合物、活化剂或催化剂。
  13. 如权利要求1所述的微环境氢气供给透气层，其特征在于，所述薄层可进一步包含氧气及活性氧生成单元。
  14. 如权利要求1所述的微环境氢气供给透气层，其特征在于，所述透气层可以用于生活卫生用品中，所述生活卫生用品包含眼罩、口罩、面罩、面膜、胸罩、胸贴、溢乳贴、卫生棉、卫生巾、纸尿裤、卫生护垫、伤口敷料、创可贴、包扎纱布、褥疮垫或外敷袋。
  15. 一种外敷袋，其特征在于，包含：
    一薄层，包裹一制氢配方、一制氧配方，所述薄层外侧不透气，内侧透气，内侧表面具多个小孔洞，所述薄层包括单层或是复合层；
    所述制氢配方，被包裹于所述薄层中，吸收空气中水分或是液态水，进而生成氢气；所述氢气通过所述多个小孔洞释放至皮肤；
    所述制氧配方，被包裹于所述薄层中，吸收空气中水分或是液态水，进而生成氧气；所述氧气通过所述多个小孔洞释放至皮肤。
  16. 如权利要求15所述的外敷袋，其特征在于，所述薄层的内侧材质包括硅胶、无纺布、或塑料透气膜。
  17. 如权利要求15所述的外敷袋，其特征在于，所述薄层的外侧材质包括聚丙烯、聚乙烯塑料薄膜、铝膜或复合膜。
  18. 如权利要求15所述的外敷袋，其特征在于，所述制氢配方、所述制氧配方包括粉末状或颗粒状。
  19. 如权利要求15所述的外敷袋，其特征在于，所述制氢配方包含金属过氧化物、金属氢氧化物、或金属氢化物、铝粉或硅粉。
  20. 如权利要求19所述的外敷袋，其特征在于，金属过氧化物或金属氢 氧化物与铝粉的重量比例为：1:100～100:1。
  21. 如权利要求20所述的外敷袋，其特征在于，金属过氧化物或金属氢氧化物与铝粉的重量比例为：1:10～10:1。
  22. 如权利要求19所述的外敷袋，其特征在于，所述金属过氧化物选自于由过氧化钙、过氧化镁、过氧化钠、过氧化钾所组成的群组。
  23. 如权利要求19所述的外敷袋，其特征在于，所述金属氢氧化物选自于由氢氧化钙、氢氧化镁、氢氧化钠、氢氧化钾所组成的群组。
  24. 如权利要求19所述的外敷袋，其特征在于，所述金属氢化物选自于由氢化镁、氢化钙、氢化硅所组成的群组。
  25. 如权利要求19所述的外敷袋，其特征在于，所述制氢配方可添加一固体酸，所述固体酸选自于由固体柠檬酸、固体乳酸、固体草酸、固体盐酸、固体植酸和固体硅酸所组成的群组，使制氢配方的酸碱度介于4-9之间。
  26. 如权利要求15所述的外敷袋，其特征在于，所述制氧配方是金属过氧化物，选自于由过氧化钙、过氧化镁、过氧化钠、过氧化钾所组成的群组。
  27. 如权利要求15所述的外敷袋，其特征在于，所述制氧配方与所述制氢配方的重量比例为1:1～1:50。
  28. 如权利要求15所述的外敷袋，其特征在于，所述发炎是指非细菌性发炎。
PCT/CN2019/085359 2019-01-25 2019-04-30 微环境氢气供给透气层及外敷袋 WO2020151125A1 (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SG11202107501RA SG11202107501RA (en) 2019-01-25 2019-04-30 Microenvironment hydrogen-supplying breathable layer and applications thereof
CA3126408A CA3126408A1 (en) 2019-01-25 2019-04-30 Microenvironment hydrogen-supplying breathable layer and applications thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/CN2019/073210 WO2020151005A1 (zh) 2019-01-25 2019-01-25 微环境氢气供给透气层
CNPCT/CN2019/073210 2019-01-25

Publications (1)

Publication Number Publication Date
WO2020151125A1 true WO2020151125A1 (zh) 2020-07-30

Family

ID=71735979

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/CN2019/073210 WO2020151005A1 (zh) 2019-01-25 2019-01-25 微环境氢气供给透气层
PCT/CN2019/085359 WO2020151125A1 (zh) 2019-01-25 2019-04-30 微环境氢气供给透气层及外敷袋

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/CN2019/073210 WO2020151005A1 (zh) 2019-01-25 2019-01-25 微环境氢气供给透气层

Country Status (3)

Country Link
CA (1) CA3126408A1 (zh)
SG (1) SG11202107501RA (zh)
WO (2) WO2020151005A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114620681B (zh) * 2021-12-24 2023-05-23 杭州江涌节能技术有限公司 一种可循环利用的制氢材料及其制备方法和应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020034553A1 (en) * 2000-09-19 2002-03-21 Janice Zayas Skin healing, conditioning and enhancing lotion
US6767342B1 (en) * 2001-04-23 2004-07-27 Evelyna D. Cantwell Oxygen bandage system
CN206007659U (zh) * 2014-03-11 2017-03-15 纳秋兰国际有限会社 卫生用品
CN106860032A (zh) * 2016-10-25 2017-06-20 曹荣华 一种气态皮肤供氧美白产品及其应用
CN206621479U (zh) * 2016-07-01 2017-11-10 曹荣华 供给氧气的亲肤性吸收结构

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101146086B1 (ko) * 2011-10-12 2012-05-11 이복연 피부미용기체의 분출마스크
CN204193090U (zh) * 2014-10-28 2015-03-11 友荃科技实业股份有限公司 氢氧气美容保健面膜
CN204121447U (zh) * 2014-10-28 2015-01-28 友荃科技实业股份有限公司 氢水美容面膜
CN108601674B (zh) * 2016-01-12 2019-05-28 竹原隆 眼罩型氢供给器
CN106235472B (zh) * 2016-09-30 2017-11-07 福州品行科技发展有限公司 一种便携口罩及其使用方法
CN206909775U (zh) * 2017-05-05 2018-01-23 安徽人本氢能科技股份有限公司 一种新型氢气口罩
CN207590987U (zh) * 2017-05-05 2018-07-10 安徽人本氢能科技股份有限公司 一种新型氢气面膜
CN107875029A (zh) * 2017-12-19 2018-04-06 广州弘皓电子科技有限公司 一种用于可发生氢气的水素面膜的氢气发生粉
CN108294960A (zh) * 2018-04-16 2018-07-20 苏州雨泉富氢生物科技有限公司 一种富氢美容面膜及其制备方法
CN109125099B (zh) * 2018-08-24 2021-04-13 杭州氢源素生物科技有限公司 一种可持续释放氢气的面膜及其使用方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020034553A1 (en) * 2000-09-19 2002-03-21 Janice Zayas Skin healing, conditioning and enhancing lotion
US6767342B1 (en) * 2001-04-23 2004-07-27 Evelyna D. Cantwell Oxygen bandage system
CN206007659U (zh) * 2014-03-11 2017-03-15 纳秋兰国际有限会社 卫生用品
CN206621479U (zh) * 2016-07-01 2017-11-10 曹荣华 供给氧气的亲肤性吸收结构
CN106860032A (zh) * 2016-10-25 2017-06-20 曹荣华 一种气态皮肤供氧美白产品及其应用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEN XI ; ZOU JIANXIN ; ZENG XIAOQIN ; DING WENJIANG: "Applications of Mg-based Hydrogen Storage Materials in Energetic Materials", CHINESE JOURNAL OF EXPLOSIVES AND PROPELLANTS, vol. 39, no. 3, 30 June 2016 (2016-06-30), pages 2 - 4, ISSN: 1007-7812, DOI: 10.14077/j.issn.1007-7812.2016.03.001 *
WANG, RONGMING ET AL: "Passage, Hydrogen Storage Material and Energy Carrier Thereof", HYDROGEN STORAGE MATERIAL AND ENERGY CARRIER THEREOF, 31 March 1998 (1998-03-31), CN, pages 54 - 65, XP009522369, ISBN: 7-5624-1621-4 *

Also Published As

Publication number Publication date
WO2020151005A1 (zh) 2020-07-30
SG11202107501RA (en) 2021-08-30
CA3126408A1 (en) 2020-07-30

Similar Documents

Publication Publication Date Title
TWI720465B (zh) 微環境氫氣供給透氣層及其用途
CN111481425A (zh) 微环境氢气供给透气层及外敷袋
TWM583850U (zh) 微環境氫氣供給透氣層及其用途
CN106726165A (zh) 一种一次性吸收物品
JP2015167840A (ja) 衛生用品
CN107596574A (zh) 一种用于祛寒暖宫和调理痛经用的护理片
US11471423B2 (en) Microenvironmental gas permeable layer capable of supplying hydrogen
JP2019194162A (ja) 肌の酸素供給による美白及び加熱機能を備えた通気性材料
JP6479897B2 (ja) 酸素を供給する肌触りの良い吸収構造
WO2020151125A1 (zh) 微环境氢气供给透气层及外敷袋
JP6814239B2 (ja) 通気層
CN204812203U (zh) 一种医用外科口罩
CN205459367U (zh) 一种应用于产科的加压腹带
JP3217927U (ja) 肌の酸素供給による美白及び加熱機能を備えた通気性材料
CN211797230U (zh) 一种供给一氧化氮的多层装置
CN109568015A (zh) 一种雅连中草药植物液棉纱布卫生巾
TWM592306U (zh) 一種供給一氧化氮之多層裝置
TWI750362B (zh) 一種具有皮膚美白供氧並具加熱功能的透氣材料
CN208405093U (zh) 一种腋臭手术术后双侧压迫腋窝垫
TWI816904B (zh) 一種供給一氧化氮之多層裝置
TW201730100A (zh) 一種可局部快速產生氧氣組合物
CN102366471B (zh) 一种温补肾虚的自热式中药贴膏剂
KR20010029068A (ko) 죽염과 운모를 유효성분으로 함유하는 질정제
JP3207724U (ja) 衛生用品
WO2021068134A1 (zh) 供给一氧化氮的多层装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19911120

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 3126408

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19911120

Country of ref document: EP

Kind code of ref document: A1