WO2020149727A3 - 12-lox 발현 촉진제를 포함하는 간 질환 예방 또는 치료용 조성물 - Google Patents

12-lox 발현 촉진제를 포함하는 간 질환 예방 또는 치료용 조성물 Download PDF

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WO2020149727A3
WO2020149727A3 PCT/KR2020/095003 KR2020095003W WO2020149727A3 WO 2020149727 A3 WO2020149727 A3 WO 2020149727A3 KR 2020095003 W KR2020095003 W KR 2020095003W WO 2020149727 A3 WO2020149727 A3 WO 2020149727A3
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expression promoter
composition
lox
liver diseases
preventing
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French (fr)
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WO2020149727A2 (ko
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이미옥
한용현
구승회
김준석
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서울대학교 산학협력단
고려대학교 산학협력단
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Publication of WO2020149727A2 publication Critical patent/WO2020149727A2/ko
Publication of WO2020149727A3 publication Critical patent/WO2020149727A3/ko

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Abstract

본 발명은 도코사헥사에노산의 효과를 향상시켜 주는 12-LOX, 또는 12-LOX의 발현 촉진제를 유효성분으로 포함하는 조성물 등에 관한 것으로, 본 발명에 따른 12-LOX, 또는 12-LOX의 발현 촉진제는 도코사헥사에노산의 간 질환 개선, 예방, 치료 효과 등을 현저히 증가시킬 수 있다.
PCT/KR2020/095003 2019-01-16 2020-01-15 12-lox 발현 촉진제를 포함하는 간 질환 예방 또는 치료용 조성물 WO2020149727A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2019-0005876 2019-01-16
KR1020190005876A KR102186416B1 (ko) 2019-01-16 2019-01-16 12-lox 발현 촉진제를 포함하는 간 질환 예방 또는 치료용 조성물

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WO2020149727A2 WO2020149727A2 (ko) 2020-07-23
WO2020149727A3 true WO2020149727A3 (ko) 2020-09-03

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PCT/KR2020/095003 WO2020149727A2 (ko) 2019-01-16 2020-01-15 12-lox 발현 촉진제를 포함하는 간 질환 예방 또는 치료용 조성물

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WO2023014070A1 (ko) * 2021-08-03 2023-02-09 연세대학교 산학협력단 Stc-1 또는 그 유도체를 포함하는 간질환 예방 또는 치료용 조성물

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160096618A (ko) * 2013-12-10 2016-08-16 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 간 질환의 감별 진단

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107530306A (zh) 2015-04-28 2018-01-02 普罗诺瓦生物医药挪威公司 结构增强的含硫脂肪酸在预防和/或治疗非酒精性脂肪性肝炎中的用途

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160096618A (ko) * 2013-12-10 2016-08-16 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 간 질환의 감별 진단

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ENGUITA, MONICA: "The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-kappaB and TGF13 pathways in hepatic stellate cells", CELL DEATH & DISEASE, vol. 14, 8 January 2019 (2019-01-08), pages 1 - 13, XP55735059 *
KIRPICH, IRINA: "The role of 12/15-lipoxygenase in a mouse model of alcoholic liver disease", THE FASEB JOURNAL, 2016, pages 30 *
NOBILI, VALERIC: "Role of docosahexaenoic acid treatment in improving liver histology in pediatric nonalcoholic fatty liver disease", PLOS ONE, 2 September 2014 (2014-09-02), pages e88005, XP55735070 *
SAMALA, NIHARIKA: "Molecular mechanisms of nonalcoholic fatty liver disease: potential role for 12-lipoxygenase", JOURNAL OF DIABETES AND ITS COMPLICATIONS, 2017, pages 1630 - 1637, XP085235824 *

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KR20200089381A (ko) 2020-07-27
KR102186416B1 (ko) 2020-12-07

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