WO2020142874A1 - Sample analysis device and estimation method for reagent distribution - Google Patents

Abstract

A sample analysis device and an estimation method for reagent distribution. After a user inputs sample information and reagent distribution information, the sample analysis device can simulate a test process of a sample according to the sample information and the reagent distribution information, calculate estimation data used for estimating a distribution effect of the reagent distribution information according to the test process, and display estimation data to the user; and the user can learn the distribution effect of the reagent distribution information according to the estimation data, thus achieving the aim of the sample analysis device estimating a reagent distribution effect.

Description

Sample analysis equipment and reagent distribution evaluation method Technical field

The invention relates to the technical field of medical devices, in particular to a sample analysis device and an evaluation method of reagent distribution.

Background technique

Sample analyzers, such as biochemical analyzers, immune analyzers, etc., are often used in clinical laboratories to detect various analytical components of blood, urine, or other body fluids to provide a basis for diagnosis of disease and body function. It can realize the simultaneous reaction and detection of multiple samples and multiple items. It has the advantages of high degree of automation, fast measurement speed, and accurate measurement results. It has been widely used in clinical testing.

In the process of sample analysis, the sample analyzer generally needs to mix the tested sample with the corresponding reagent according to the test item, and then complete the analysis of the sample according to the mixing result. Therefore, each sample analyzer is equipped with a reagent unit for providing reagents required for the test. The reagent unit can rotate and position each reagent container holding the reagent to the corresponding reagent suction position. For a sample analyzer with multiple reagent units, it is necessary to distribute reagents to different reagent units during use. Different reagent distribution methods will have a direct impact on the evaluation indexes such as the test speed and working time of the sample analyzer.

At present, the effects of different reagent distribution methods of the sample analyzer are mainly subjectively evaluated by the operator based on long-term use experience, and subjective factors have a greater influence.

Summary of the invention

The invention mainly provides a sample analysis device and a reagent distribution evaluation method, so that the sample analysis device can evaluate the effect of reagent distribution.

According to a first aspect, an embodiment provides a sample analysis device, including an input device, an analysis device, a processor, and a display device;

The analysis device is connected to the processor for analyzing a sample, and the analysis device includes at least two reagent units, and the reagent unit is used to provide reagents for sample analysis;

The input device is connected to the processor for detecting sample information and reagent distribution information input by the user, and inputting the sample information and the reagent distribution information to the processor, the reagent distribution information is for the user Information of reagents distributed on each reagent unit;

The processor is used to simulate a test process of the sample based on the sample information and the reagent allocation information, calculate evaluation data according to the test process, and send the evaluation data to the display device, the evaluation data is used to Evaluate the distribution effect of the reagent distribution information;

The display device is connected to the processor for displaying the evaluation data.

According to a second aspect, an embodiment provides a reagent distribution evaluation method, including:

Simulate the testing process of the sample based on the sample information and the reagent distribution information input by the user through the input device, and the reagent distribution information is the information of the reagent distributed on each reagent unit;

Calculating evaluation data according to the test process, the evaluation data being used to evaluate the distribution effect of the reagent distribution information;

The evaluation data is sent to the display device for display.

According to the sample analysis device and the reagent distribution evaluation method of the above embodiment, after the user inputs the sample information and the reagent distribution information, the sample analysis device can simulate the test process of the sample based on the sample information and the reagent distribution information, and calculate the usefulness accordingly Evaluation data for evaluating the distribution effect of the reagent distribution information and displaying the evaluation data to the user. Therefore, the purpose of the sample analysis equipment to evaluate the effect of reagent distribution is achieved.

BRIEF DESCRIPTION

1 is a schematic structural diagram of a sample analysis device according to an embodiment of the present invention;

2 is a schematic structural diagram of a sample analysis device according to a specific embodiment of the present invention;

3 is a schematic structural diagram of a sample analysis device according to another specific embodiment of the present invention;

4 is a flowchart of a method for evaluating reagent distribution in an embodiment of the present invention;

5 is a schematic diagram of an information input interface of the present invention;

6 is a flowchart of a method for evaluating reagent distribution in a specific embodiment of the present invention;

7 is a schematic diagram of another sample information input interface of the present invention;

8 is a schematic diagram of another sample information input interface of the present invention;

9 is a schematic diagram of a reagent allocation information entry interface of the present invention;

10 is a flowchart of a method for evaluating reagent distribution in another specific embodiment of the present invention.

detailed description

The present invention will be further described in detail below through specific embodiments and drawings. Unless otherwise specified, "connection" and "connection" in this application include direct and indirect connections (connections).

The sample analysis equipment may include a single machine (one analyzer) or a combination (at least two analyzers cascade) of instruments such as a biochemical analyzer, an immunoanalyzer, etc., so as to perform biochemical, immunological, or biochemical and immunological analysis on the sample. The sample can be analyte in serum, plasma or other body fluids. Sample analysis equipment is usually composed of analysis module, injection control unit, processor and so on. The analysis module contains at least one reagent unit. The analysis module is mainly used to analyze analytes in serum, plasma and other body fluids; the injection control unit mainly controls the input, scheduling, transmission, positioning and recovery of the sample rack , And automatically identify the barcode information of the sample rack and sample tube; the processor can realize the functions of data input, data output, test result evaluation and quality control of the sample analysis equipment.

For a single machine containing multiple reagent units in an analysis module, or a sample interconnection device including multiple reagent units formed by cascading multiple analysis modules, users often distribute reagents to different reagent units according to different usage requirements. In this process, different reagent distribution methods will have an impact on the department's test speed, TAT time (time to complete the test) and other important evaluation indicators of the department.

The current sample analysis equipment does not have the function of predicting the effect of reagent distribution. For a reagent distribution method, the effect needs to be evaluated by manual calculation, or after a period of use of the sample analysis equipment In order to evaluate the effect according to the specific use situation, and this evaluation is very susceptible to the user's subjective factors. With the diversification of user customization needs, the increase in the number of interconnected analysis modules, and the gradual increase in reagent storage capacity, the need to predict the distribution effect of reagents is also increasing, and users prefer to be able to analyze by samples The device estimates the current reagent distribution method to evaluate whether it can meet specific requirements without manual evaluation, or the user must experience the effect after a period of actual use.

In order to reduce the scenes that the user needs to manually estimate to the greatest extent, and at the same time ensure that the use effect after distribution meets the requirements to the greatest extent, the solution of the present invention is proposed.

In the embodiment of the present invention, as long as the user inputs the sample information and the reagent allocation information, the sample analysis device can simulate the test process of the sample based on the sample information and the reagent allocation information, calculate the evaluation data, and then display the obtained evaluation data to the user , The user can know the distribution effect of the reagent distribution information through the evaluation data.

An embodiment of the present invention provides a sample analysis device. For a schematic structural diagram, refer to FIG. 1. The sample analysis device includes an input device 1, an analysis device 2, a processor 3, and a display device 4. The input device 1, an analysis device 2, and a display device 4 Connected to the processor 3 respectively. The analysis device 2 is used to analyze the sample. The analysis device 2 includes at least two reagent units S, and the reagent unit S is used to provide reagents for sample analysis.

Based on FIG. 1, in a specific embodiment, the sample analysis device may include only one analyzer, such as a biochemical analyzer or an immunoassay analyzer, and the analysis device 2 of the sample analysis device includes an analysis Module 21. The analysis module 21 may be a biochemical analysis module or an immunoassay module. The analysis module 21 includes at least two reagent units S. For a schematic structural diagram, see FIG. 2. In another specific embodiment, the sample analysis device may include a combination of at least two analyzers, for example, at least two biochemical analyzers, at least two immunoassay analyzers, or at least one biochemical analyzer and at least one A combination of two immunoassay analyzers, the analysis device 2 of the sample analysis device includes at least two analysis modules 21, and the at least two analysis modules 21 may both be biochemical analysis modules or immunoassay modules, or may be partly biochemical analysis modules, part It is an immunoassay module, that is, the types of the at least two analysis modules 21 may be the same or different, wherein each analysis module 21 includes at least one reagent unit S, and a schematic structural diagram thereof may be shown in FIG.

In practical applications, the reagent units S may be disk-shaped reagent trays. When an analysis module 21 includes at least two reagent units S, the reagent units S may be arranged in a dispersed manner, as shown in FIG. 2; these reagent units S may also be at least two coaxial arrangements, for example, one analysis module 21 includes two reagent units S, and these two reagent units S respectively form a coaxial inner ring and an outer ring, that is, form a double ring structure.

For the sample analysis devices of the various structures described above, the input device 1 is used to detect the sample information and reagent distribution information input by the user, and input the sample information and reagent distribution information to the processor 3, wherein the reagent distribution information is provided by the user in each Information of the reagent distributed on the reagent unit S. The processor 3 is used to simulate the test process of the sample based on the sample information and reagent allocation information input by the user, calculate the evaluation data according to the test process, and send the obtained evaluation data to the display device 4, the evaluation data is used to evaluate the reagent distribution information Distribution effect. The display device 4 is used to display the evaluation data obtained by the processor 3.

In practical applications, the sample analysis device may further include a memory, and the processor 3 saves the obtained evaluation data in the memory when receiving the save instruction input by the user through the input device 1. In this way, the processor 3 can compare the evaluation data corresponding to the at least two reagent distribution information stored in the memory, respectively, and output the comparison result to the display device 4 for display. Based on the comparison result, the user can know which reagent dispensing method has the better dispensing effect to meet the current requirements.

Based on the sample analysis device of the above embodiment, an embodiment of the present invention also provides a method for evaluating reagent distribution. For the flowchart, refer to FIG. 4. The method may include the following steps:

Step 101: Obtain sample information and reagent allocation information.

When the user inputs sample information and reagent distribution information through the input device 1, the processor 3 acquires the sample information and reagent distribution information. The sample information may include the total number of samples and the test items of each sample; or, it may be the number of samples per batch, the test items of each batch of samples, and the on-time of each batch of samples. The reagent allocation information is the information of the reagents allocated by the user on each reagent unit, and the reagent allocation information may include the correspondence between each reagent unit S and the type of the allocated reagent, where the reagent type corresponds to the detection item in the sample information.

Step 102: Simulate the testing process of the sample.

The processor 3 simulates the test process of the sample based on the sample information and reagent distribution information input by the user through the input device 1.

Step 103: Calculate the evaluation data.

The processor 3 calculates evaluation data according to the simulated test process of the sample, and the evaluation data is used to evaluate the distribution effect of the reagent distribution information input by the user. The evaluation data may be the evaluation of the overall effect of the sample analysis device, the evaluation of the effects of each analysis module in the sample analysis device, or the evaluation of the effect of the entire device and each analysis module at the same time. The calculated evaluation data can be data related to factors such as time or speed. For example, through the test process of the simulated samples (all samples in the sample information entered by the user), the test duration of each sample can be calculated, and the total amount of all samples measured. Data such as duration, average test duration of a single sample, test speed of the whole machine, and test speed of a single analysis module. For sample analysis equipment including multiple reagent units, different reagent distribution methods have different effects on the scheduling efficiency and test efficiency of the sample; by calculating these evaluation data, specific reagent distribution methods (reagent distribution entered by the user) can be known in advance The corresponding effect of the reagent distribution method corresponding to the information) provides a reference for the user to perform reagent distribution.

Step 104: Display evaluation data.

After the processor 3 calculates the evaluation data, it sends the evaluation data to the display device 4 for display.

The sample analysis equipment and the reagent distribution evaluation method provided by the embodiments of the present invention can input the sample information and reagent distribution information through the input device when the user wants to know the use effect of the sample analysis equipment in a certain reagent distribution mode. , The processor will simulate the test process of the sample based on this information and calculate the evaluation data, and then display the evaluation data to the user. Based on the evaluation data, the user can know the distribution effect of the reagent distribution information, and realize the distribution of reagents by the sample analysis equipment. The function of predicting the effect can facilitate the user to check the reagent distribution effect in various situations in advance, so that the user can select the appropriate reagent distribution strategy from it.

In the embodiment of the present invention, the evaluation of the reagent distribution effect may be the evaluation of the entire machine of the sample analysis device, or the evaluation of each reagent unit in the sample analysis device, or the evaluation of both. The solution of the present invention will be described in detail below by taking the evaluation of the effect of the whole machine of the sample analysis device as an example.

Here, taking a sample analysis device including two reagent units (respectively referred to as S1 and S2) as an example, the two reagent units may be located in two analysis modules 21, respectively.

The sample analysis device provides the user with an information input interface when estimating the reagent distribution effect. When the user needs to estimate the reagent distribution effect, the information input interface is displayed through the display device 4. FIG. 5 shows an information entry interface, which may include a sample information entry window and a reagent allocation information entry window. The user may enter sample information in the sample information entry window, and enter reagent allocation information in the reagent allocation information entry window.

FIG. 6 is a flowchart of a method for evaluating reagent distribution in a specific embodiment of the present invention. As shown in FIG. 6, the method may include the following steps:

Step 201: Obtain sample information.

The user inputs the sample information through the input device 1 according to the information input interface displayed on the display device 4. At this time, the processor 3 obtains the sample information.

For example, as shown in Figure 5, the user can enter the total number of samples in the "total number" option, such as 10 samples, and then enter the 10 samples of each sample in the "test item" of the "sample" item. Test items. You can enter the name of the test package in the "test item", such as "HBV five" for sample 1 and sample 4, or you can enter each test item, such as ACTH (adrenal cortex) for sample 2 Hormones), enter Anti-HCV (Hepatitis C Antibody), HIV (HIV) and Anti-TP (Syphilis) for Sample No. 3. For the convenience of operation, it is also possible to provide a selection menu of test items for each sample. The user can select the test item from this menu. For example, FIG. 7 shows a schematic diagram of another sample information input interface, which can be provided for each The sample provides the corresponding "select test item" function menu. When the user clicks this menu, a list of optional test items pops up. For example, click the sample 1 "select test item" menu. The pop-up test item list includes ACTH, Anti-HCV, HIV, Anti-TP and other testing items, the user selects the desired testing items in this list, and then clicks the "OK" button in the testing item list to select the testing items. After entering the sample information for each sample, the user clicks the "OK" function key in the sample information entry window to complete the sample information input.

In practical applications, you can also input sample information by batch. The sample information at this time can include the number of samples in each batch, the test items for each batch of samples, and the time for each batch of samples to be on-board. The user only needs to enter this information for each batch of samples. That's it. For example, FIG. 8 shows another sample information input window, and the user can enter the number and test of the first batch of samples in the "quantity", "test items", and "on-time" of the "first batch". Projects and on-board time, for example, enter "10", "Hepatitis B five items" and "9:00", then there are 10 samples in the first batch, and the test items of each sample are five hepatitis B items. Boarding at 9:00. If there are multiple batches of samples, you can add these three items of information entry for each batch of samples such as batch 2 and batch 3 through the "Add" function key. Finally, click the "OK" button to complete the sample information input.

Step 202: Obtain reagent distribution information.

The user inputs the reagent distribution information through the input device 1 according to the information input interface displayed on the display device 4. At this time, the processor 3 obtains the reagent distribution information.

For example, in the information entry interface shown in FIG. 5, the user can open a reagent allocation information entry window to enter reagent allocation information. Fig. 9 shows a reagent distribution information entry interface. The user can input the assigned reagent type in the "reagent type" corresponding to the reagent units S1 and S2 respectively according to the detection items in the entered sample information. The reagent type and sample Corresponding to the detection item in the message, as long as the detection item is determined, the reagent type is determined. For convenience, the detection item can be directly entered in "Reagent Type". For example, if the user only enters the first batch of samples in the sample information input window shown in Figure 8, the input test item is "five hepatitis B items", then the user can assign the five hepatitis B items to S1 and S2, such as S1 HBeAg, HBsAg and Anti-HBc are entered in S2, and Anti-HBs and Anti-HBe are entered in S2. Click "OK" to complete the input of reagent allocation information. If the user enters multiple batches of samples in the sample information input window shown in FIG. 8, or enters sample information of multiple samples in the sample information input window shown in FIG. 5, the user needs to include all the test items included in the sample Assigned to S1 and S2.

In practical application, it is convenient for the user to input the reagent distribution information and avoid the information input error. In the reagent distribution information input window shown in FIG. 8, it is also possible to set the “select reagent type” for S1 and S2 as shown in FIG. 7. Function menu, when the user clicks on this menu, a list of selectable test items pops up, and only the test items entered by the user in the sample information input window are displayed in this list, so that the user only needs to select the allocation in the test item list as needed Just go to the test item on S1 or S2.

Step 203: Calculate the whole machine evaluation data.

After receiving the sample information and reagent distribution information input by the user through the input device 1, the processor 3 simulates the test process of the sample based on the sample information and reagent distribution information, and calculates the overall evaluation data of the sample analysis device according to the test process. The machine evaluation data may include the first total test time, the first average sample test time, the longest sample test time, and/or the first test speed.

Specifically, the processor 3 may calculate the overall evaluation data of the sample analysis device according to the following steps A1 to C1:

Step A1: Pre-arrange the sample detection sequence.

After receiving the sample information and reagent distribution information input by the user through the input device 1, the processor 3 pre-arranges the sample suction time for all samples according to the sample information and reagent distribution information, so that the sample information of all samples in the sample information can be determined Detection sequence. For example, the user enters sample information and reagent allocation information for 40 samples (or four sample racks with 10 samples loaded on each sample rack). The sample information for each sample includes test item information, and the input of 40 samples The sample information has a sequence, which can be used as a reference factor for pre-arranging the sample detection sequence; in addition, the reagent distribution information entered by the user can determine the reagents allocated to each reagent unit, and the analysis module where each reagent unit is located can be executed The test items can also be determined accordingly, and the sample test sequence can be pre-arranged according to the matching of the test items that each analysis module can perform with the sample test item information; for example, according to the reagent allocation information, it can be determined that the first analysis module can execute the For a test item, the sequence of samples including the first test item is sent to the first analysis module for testing.

Step B1: Simulate the testing process of the sample.

After pre-arranging the sample suction time, the processor 3 can simulate the test process of the sample according to the sample suction time. Specifically, starting from the first sample, the processor 3 may simulate the test process of the normal sample test of the sample analysis device according to the pre-arranged sample suction time or sequence, and simulate the test process of all samples to detect the corresponding test items, Until all samples are tested. For example, the user inputs the sample information and reagent allocation information of 40 samples, and the target analysis module of each sample can be determined according to the reagent allocation information, for example, the test items of samples 1-20 are the first test items, and the test items of samples 21-40 It is the second test item, and it can be known from the reagent allocation information that the first analysis module can execute the first test item and the second analysis module can execute the second test item, then the target analysis module for samples 1-20 may be the first analysis module, The target analysis module of samples 21-40 is the second analysis module, and the simulation process may include: scanning the samples 1-20 in sequence and dispatching the samples 1-20 to the first analysis module for sampling and testing, and executing The detection of the first test item; scan the samples 21-40 in sequence and dispatch the samples 21-40 to the second analysis module for sampling, and perform the detection of the second test item.

Step C1: Calculate the whole machine evaluation data according to the test process of the sample.

The processor 3 calculates the evaluation data of the whole machine according to the test process of the simulated sample. For example, the processor 3 can estimate the time for each sample from completing the barcode scanning to obtain the sample test result, and each sample from the sample suction to the corresponding test The timing of the results of the project, etc.

In the process of calculating the evaluation data of the whole machine, the processor 3 can, according to the above estimation function, for each sample, start the barcode scanning time of the sample as the detection start time of the sample, complete the test of the sample and obtain The time when the test result is output is taken as the test end time of the sample. Alternatively, for each sample, the sample suction time when the first test item is detected may be used as the test start time of the sample.

Specifically, for the first total test time, the processor 3 records the test start time of the first sample and the test end time of the last sample during the test of the simulated sample to obtain the first test start time T1 and the first test End time T2, and then calculate the time difference between T1 and T2 to get the first total test time. In practical applications, the overall machine evaluation data may further include the first test start time and/or the first test end time.

In practical applications, when calculating the first total test time, the time when the simulation process is started after the user inputs the sample information and the reagent allocation information can be used as the first test start time.

For the first average sample test time, the processor 3 records the test start time and test end time of each sample during the test of the simulated sample, and calculates the value of each sample based on the test start time and test end time of each sample Test time, then calculate the sum of the test time of all samples to get the total test time, and then calculate the average test time of each sample based on the total test time and the total number of samples or the number of samples in each batch to get the first average sample testing time.

For example, the total number of samples is 5, and the processor 3 records the test start time and test end time of each sample during the test of the simulated sample, and calculates the test time of these 5 samples as t1, t2, and t3 accordingly , T4 and t5, the first average sample test time can be calculated according to the formula (t1+t2+t3+t4+t5)/5. If the number of samples in each batch is given, the number of samples in each batch can be summed to obtain the total number of samples, and the first average sample test time can be obtained in the same way.

For the longest sample test time, the processor 3 records the test start time and test end time of each sample during the test of the simulated sample, and calculates the test of each sample based on the test start time and test end time of each sample Time, and then obtain the longest test time from these test times, and use the longest test time as the longest sample test time.

For the first test speed, the processor 3 obtains the total number Q of test items of all samples during the test of the simulated samples, and records the test start time of the first sample and the test end time of the last sample to obtain the first The test start time T1 and the first test end time T2, then calculate the time difference between T1 and T2 to obtain the first total test time T, and finally calculate the ratio of Q to the T to obtain the first test speed Q/T.

The evaluation data of the whole machine may also include the shortest sample test time. During the test of the simulated sample, the processor 3 records the test start time and test end time of each sample, and calculates based on the test start time and test end time of each sample The test time of each sample is obtained, and then the shortest test time is obtained from these test times, and the shortest test time is taken as the shortest sample test time.

Step 204: Display the whole machine evaluation data.

After the processor 3 calculates the whole machine evaluation data, it sends the whole machine evaluation data to the display device 4 for display. Specifically, the display device 4 can display the whole machine evaluation data in the form of a graph.

After the processor 3 sends the whole machine evaluation data to the display device 4 for display, it can also perform the following steps:

Step 205: Store the whole machine evaluation data.

The processor 3 stores the whole machine evaluation data. Specifically, the input device 1 detects the user's operation of saving the entire machine evaluation data, generates a save instruction according to the operation, and then sends the save instruction to the processor 3. When receiving the save instruction, the processor 3 saves the whole machine evaluation data in the memory, so that the user can view the whole machine evaluation data at any time, or perform further analysis on the evaluation data.

The above method embodiments are exemplified by evaluating the effect of the entire sample analysis device. In practical applications, the effect of each analysis module in the sample analysis device can also be evaluated, or the effect of the whole machine and each analysis module can be evaluated at the same time.

FIG. 10 is a flowchart of an evaluation method of reagent distribution in another specific embodiment of the present invention. The method is described by taking the example of evaluating the reagent distribution effect of the analysis module where each reagent unit in the sample analysis device is located, as shown in FIG. According to 10, the method may include the following steps:

Step 301 and step 302 are the same as step 201 and step 202, and will not be repeated here.

Step 303: The calculation and analysis module evaluates the data.

After receiving the sample information and reagent distribution information input by the user through the input device 1, the processor 3 simulates the test process of the sample based on the sample information and reagent distribution information, and calculates the evaluation data (i.e., reagents) of the analysis module of the sample analysis device according to the test process Evaluation data of the analysis module where the unit is located), the analysis module evaluation data may include a second average sample test time, a second test speed, a second test start time, a second test end time, and/or a sample aspiration maximum waiting time.

Specifically, the processor 3 may calculate the evaluation data of the analysis module of the sample analysis device according to the following steps A2 to C2:

The specific processes of step A2 and step B2 are the same as step A1 and step B1, respectively.

Step C2: Calculate the evaluation data of the analysis module according to the test process of the sample.

The processor 3 calculates the analysis module evaluation data according to the test process of the simulated sample.

Specifically, the second test start time is the time when the analysis module where the reagent unit is located starts to detect the first test item, or the sample suction time when the first test item starts to be detected. This time can be simulated by the processor 3 in the sample Recorded during the test. The second test end time is the time when the analysis module where the reagent unit is located completes the last test item, and this time can also be recorded by the processor 3 during the test process of the simulated sample. The analysis module mentioned here is for an analysis module. The sampling waiting time is the time from the end of the current sampling to the next sampling start on the same analysis module, which can be recorded by the processor 3 during the test of the simulated sample, after the test on the analysis module is completed , And take the longest time from the recorded time as the longest waiting time for aspiration. In practical applications, the processor 3 can also record the time point of the longest waiting time of the suction.

For the second average sample test time, the processor 3, during the test of the simulated sample, for each analysis module (that is, the analysis module where the reagent unit is located), for each sample that is tested on the analysis module, record the sample’s Test start time k1 and test end time k2, where the test start time k1 may be the time when the analysis module starts to detect the first test item of the sample on the analysis module, or it may be when the analysis module starts to detect the sample Sample suction time. Then, the processor 3 calculates the test time k of each sample according to k1 and k2, that is, k=k2-k1; then, calculates the sum of the test time k of all samples to obtain the total test time Y; The total number of samples tested on the analysis module calculates the average test time of each sample to obtain the second average sample test time.

For example, the samples tested on the analysis module M1 are three samples A, B, and C. For sample A, the processor 3 records the time k1 _A when _A starts the test on M1 and the time k2 _A when the test ends, and then a test of the calculated time k _a = k1 _a -k2 _a; the same, time the test sample is obtained and C K B K _B and _C; after obtaining total test time a, B and C, the three samples Y=k _A +k _B +k _C ; Finally, the second average sample test time Y′ of the three samples is obtained according to Y′=Y/3.

For the second test speed, the processor 3 obtains the total number R of test items for which the sample is tested on the analysis module for each analysis module during the test of the simulated sample, and records that the analysis module starts to detect the first The time of the test item and the time of completing the last test item are the second test start time m1 and the second test end time m2, and then the time difference between m1 and m2 is calculated to obtain the second total test time M of the analysis module, that is, M = M2-m1; finally calculate the ratio of R and M to obtain the second test speed R/M.

Step 304: Display analysis module evaluation data.

Similar to step 204, after the processor 3 calculates the analysis module evaluation data, it sends the analysis module evaluation data to the display device 4 for display. Specifically, the display device 4 may also display the evaluation data of the analysis module in the form of a graph.

After the processor 3 sends the analysis module evaluation data to the display device 4 for display, it may also perform a similar step 305 as in FIG. 6:

Step 305: Store and analyze the module evaluation data.

In practical applications, the processor 3 can also calculate the whole machine evaluation data and the analysis module evaluation data at the same time when simulating the sample testing process, and then send the obtained whole machine evaluation data and analysis module evaluation data to the display device 4, the display device 4 The evaluation data of the whole machine and the evaluation data of the analysis module can be displayed simultaneously in the form of a graph.

In practical applications, after storing the whole machine evaluation data and/or the analysis module evaluation data, the reagent distribution evaluation method further includes the following steps a to c:

Step a: Obtain evaluation data.

The memory has stored evaluation data of a variety of different reagent distribution methods (i.e. reagent distribution information). At this time, the processor 3 can obtain evaluation data corresponding to at least two reagent distribution information from the memory. For example, the sample analysis device can display the comparative analysis menu through the display device. The user wants to compare the reagent distribution method 1 and the reagent distribution method 2 stored in the memory. The two types can be selected from the comparative analysis menu through the input device 1 Reagent distribution mode. At this time, the input device 1 generates a comparison instruction and sends it to the processor 3. When the processor 3 receives the comparison instruction, it obtains evaluations corresponding to the reagent distribution method 1 and the reagent distribution method 2 from the memory according to the comparison instruction. data. Alternatively, the user can also compare the current reagent distribution method with the reagent distribution method stored in the memory.

Step b: Compare and evaluate the data.

After the processor 3 obtains the evaluation data corresponding to the at least two reagent allocation information, the two evaluation data are compared to obtain a comparison result. For example, comparing the first average sample test time and the longest sample test time in the reagent distribution method 1 with the first average sample test time and the longest sample test time in the reagent distribution method 2, respectively, the first average sample can be obtained The reagent distribution method with the shortest test time and the reagent distribution method with the shortest sample test time.

Step c: Display the comparison result.

After the processor 3 obtains the comparison result, it outputs the comparison result to the display device 4 for display. In actual application, the comparison evaluation data and the comparison result can be displayed at the same time, and can also be displayed in the form of a graph.

In the sample analysis equipment and reagent distribution evaluation method provided by the embodiments of the present invention, the user can input sample information and reagent distribution information through the input device. At this time, the processor will simulate the sample test process based on the information and calculate the whole machine evaluation data And/or analysis module evaluation data, and then display the whole machine evaluation data and/or analysis module evaluation data to the user, based on these data, the user can know the use effect of the reagent distribution information on the whole machine and/or the reagent unit The use effect achieved by the analysis module where it is implemented realizes the function of the sample analysis equipment to estimate the distribution effect of the reagent, and the effect of the reagent distribution can be estimated when the machine is first installed, which is convenient for the user to know or view the reagent in various situations in advance Assign effects. Further, the calculated evaluation data of the whole machine and/or the evaluation data of the analysis module can be stored in a memory to facilitate the user to view at any time, or perform further analysis on these data. In addition, the evaluation data of the whole machine and/or the evaluation data of the analysis module corresponding to different reagent distribution information can be compared to facilitate the user to select a suitable reagent distribution strategy therefrom.

The solution proposed by the present invention can also be applied to at least the following scenarios:

(1) Multiple single machines are upgraded to interconnected sample analysis equipment.

In this scenario, the user has only multiple sample analyzers. For certain requirements, such as increasing the test speed, the multiple sample analyzers need to be interconnected and upgraded to a sample analysis device with multiple analysis modules . Since the user is only familiar with the reagent distribution data of each stand-alone, if the reagent distribution status of each analysis module of the connected device is still consistent with the original analysis module, it is unknown whether it can also meet the user's use requirements. In this case By adopting the solution of the present invention, it is possible to provide the user with an estimate of the effect of reagent distribution, so that the user knows in advance the use effect of reagent distribution.

(2) After using a cascade of multiple sample analyzers for a period of time, you want to upgrade or replace the sample analyzer.

The user has already allocated reagents to the original reagent units. When at least one of the sample analyzers is upgraded or replaced with a new sample analyzer, can the new cascade equipment meet the original requirements, or After adding a certain amount of testing, whether the new cascade device can also meet the requirements such as normal time completion, etc. In this scenario, the solution of the present invention can be used to estimate in advance.

This document refers to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications can be made to the exemplary embodiments without departing from the scope of this document. For example, various operating steps and components for performing the operating steps can be implemented in different ways according to the specific application or considering any number of cost functions associated with the operation of the system (eg one or more steps can be deleted, Modify or incorporate into other steps).

In addition, as understood by those skilled in the art, the principles herein may be reflected in a computer program product on a computer-readable storage medium that is pre-installed with computer-readable program code. Any tangible, non-transitory computer-readable storage medium can be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-ROM, DVD, Blu-ray disks, etc.), flash memory, and/or the like . These computer program instructions can be loaded onto a general-purpose computer, a dedicated computer, or other programmable data processing equipment to form a machine, so that these instructions executed on a computer or other programmable data processing device can generate a device that implements a specified function. These computer program instructions can also be stored in a computer-readable memory, which can instruct a computer or other programmable data processing device to operate in a specific manner, so that the instructions stored in the computer-readable memory can form a piece Manufactured products, including implementation devices that implement specified functions. Computer program instructions can also be loaded onto a computer or other programmable data processing device, so that a series of operating steps are performed on the computer or other programmable device to produce a computer-implemented process that allows the computer or other programmable device to execute Instructions can provide steps for implementing specified functions.

Although the principles herein have been shown in various embodiments, many modifications of structures, arrangements, ratios, elements, materials, and components that are particularly suitable for specific environments and operating requirements can be made without departing from the principles and scope of this disclosure use. The above modifications and other changes or amendments will be included within the scope of this article.

The foregoing specific description has been described with reference to various embodiments. However, those skilled in the art will recognize that various modifications and changes can be made without departing from the scope of the present disclosure. Therefore, consideration of this disclosure will be in an illustrative rather than a restrictive sense, and all such modifications will be included within its scope. Also, there have been the above-mentioned advantages, various advantages, and solutions to the problems of various embodiments. However, benefits, advantages, solutions to problems, and any elements that can produce these, or solutions that make them more explicit, should not be interpreted as critical, necessary, or necessary. The term "comprising" and any other variants used in this article are non-exclusive, so that a process, method, article, or device that includes a list of elements includes not only these elements, but also those that are not explicitly listed or do not belong to the process , Methods, systems, articles or other elements of equipment. In addition, the term "coupled" and any other variations thereof as used herein refer to physical connection, electrical connection, magnetic connection, optical connection, communication connection, functional connection, and/or any other connection.

Those skilled in the art will recognize that many changes can be made to the details of the above-described embodiments without departing from the basic principles of the invention. Therefore, the scope of the present invention should be determined according to the following claims.

Claims (38)

1. A sample analysis device, characterized in that it includes an input device, an analysis device, a processor, and a display device;

   The analysis device is connected to the processor for analyzing a sample, and the analysis device includes at least two reagent units, and the reagent unit is used to provide reagents for sample analysis;

   The input device is connected to the processor for detecting sample information and reagent distribution information input by a user, and inputting the sample information and the reagent distribution information to the processor, the reagent distribution information is Information about the reagents distributed on each reagent unit;

   The processor is used to simulate a test process of the sample based on the sample information and the reagent allocation information, calculate evaluation data according to the test process, and send the evaluation data to the display device, the evaluation data is used to Evaluate the distribution effect of the reagent distribution information;

   The display device is connected to the processor for displaying the evaluation data.
2. The sample analysis apparatus according to claim 1, wherein the analysis device includes an analysis module, and the analysis module includes at least two of the reagent units.
3. The sample analysis apparatus according to claim 1, wherein the analysis device includes at least two analysis modules, and each of the analysis modules includes at least one of the reagent units.
4. The sample analysis device according to claim 2 or 3, wherein the sample information includes the total number of samples and the test items for each sample; or, the sample information includes the number of samples per batch and the number of samples per batch Test items and the on-board time of each batch of samples;

   The reagent allocation information includes a correspondence relationship between each reagent unit and the type of reagent that is allocated, and the reagent type corresponds to the detection item.
5. The sample analysis device according to claim 4, wherein when the processor simulates a test process of a sample based on the sample information and the reagent allocation information, the processor is specifically used to analyze the sample information and the reagent Distribute information, pre-arrange the testing order of all samples, and simulate the testing process of all samples according to the pre-arranged testing order.
6. The sample analysis device according to claim 5, wherein the processor is specifically configured to pre-arrange the sampling time for all samples to start aspiration based on the sample information and the reagent allocation information, starting from the first Starting with the sample, according to the sampling time, the test process of simulating all the corresponding test items of all samples is tested.
7. The sample analysis device according to claim 5, wherein the evaluation data includes whole machine evaluation data and/or analysis module evaluation data, and the analysis module evaluation data is the evaluation data of the analysis module where the reagent unit is located .
8. The sample analysis device according to claim 7, wherein the overall evaluation data includes a first total test time, a first average sample test time, a longest sample test time, and/or a first test speed.
9. The sample analysis device according to claim 8, wherein the whole machine evaluation data is a first total test time, and the processor is specifically used in the test when calculating the evaluation data according to the test process During the process, record the test start time of the first sample and the test end time of the last sample to obtain the first test start time and the first test end time, and calculate the first test start time and the first test end time Time difference to obtain the first total test time.
10. The sample analysis device according to claim 9, wherein the overall evaluation data further includes the first test start time and/or the first test end time.
11. The sample analysis device according to claim 8, wherein the whole machine evaluation data is a first average sample test time, and the processor is specifically used when calculating evaluation data according to the test process: During the test, record the test start time and test end time of each sample, calculate the test time of each sample according to the test start time and test end time of each sample, and find the sum of the test time of all samples, and The average test time of each sample is calculated according to the sum of the test time of all samples and the total number of samples or the number of samples of each batch, to obtain the first average sample test time.
12. The sample analysis device according to claim 8, wherein the whole machine evaluation data is the longest sample test time, and when the processor calculates the evaluation data according to the test process, it is specifically used to: During the test, record the test start time and test end time of each sample, calculate the test time of each sample according to the test start time and test end time of each sample, and obtain the most from the test time of each sample Long test time, get the longest sample test time.
13. The sample analysis device according to claim 8, characterized in that the whole machine evaluation data is a first test speed, and the processor is specifically used when calculating the evaluation data according to the test process: in the test During the process, obtain the total number of test items of all samples, record the test start time of the first sample and the test end time of the last sample, obtain the first test start time and the first test end time, and calculate the first test The time difference between the start time and the end time of the first test obtains the first total test time, calculates the ratio of the total number of items to the first total test time, and obtains the first test speed.
14. The sample analysis device according to claim 7, wherein the analysis module evaluation data includes a second average sample test time, a second test speed, a second test start time, a second test end time, and/or a sample suction The longest waiting time.
15. The sample analysis device according to claim 14, wherein the evaluation data of the analysis module is a second average sample test time, and the processor is specifically used when calculating evaluation data according to the test process: In the test process, for the analysis module where the reagent unit is located, for each sample tested on the analysis module, record the test start time and test end time of the sample, and calculate based on the test start time and test end time of each sample Calculate the test time of each sample, calculate the sum of the test time, and calculate the average test time of each sample based on the sum of the test time and the total number of samples tested on the analysis module to obtain the first 2. Average sample test time.
16. The sample analysis device according to claim 14, wherein for the analysis module where the reagent unit is located, the second test start time is the time when the analysis module starts to detect the first test item, and the second test ends Time is the time for the analysis module to complete the last test item;

    The processor is specifically configured to record the second test start time and/or the second test end time during the test.
17. The sample analysis device according to claim 14, wherein the evaluation data of the analysis module is a second test speed, and when the processor calculates the evaluation data according to the test process, it is specifically used for: During the process, for the analysis module where the reagent unit is located, obtain the total number of test items that were tested on the analysis module, record the time when the analysis module started to detect the first test item and the time when the last test item was completed. The second test start time and the second test end time, calculate the time difference between the second test start time and the second test end time to obtain the second total test time of the analysis module, calculate the total number of times and the The ratio of the second total test time gives the second test speed.
18. The sample analysis device according to claim 1, wherein the display device is specifically configured to display the evaluation data in the form of a graph.
19. The sample analysis device according to claim 1, further comprising a memory, and the processor saves the evaluation data in the memory when receiving a save instruction input by the user through the input device.
20. The sample analysis device according to claim 19, wherein the processor is further configured to compare the evaluation data corresponding to the at least two reagent distribution information stored in the memory, and output the comparison result to all The display device displays.
21. An evaluation method of reagent distribution, characterized in that it includes:

    Simulate the testing process of the sample based on the sample information and the reagent distribution information input by the user through the input device, and the reagent distribution information is the information of the reagent distributed on each reagent unit;

    Calculating evaluation data according to the test process, the evaluation data being used to evaluate the distribution effect of the reagent distribution information;

    The evaluation data is sent to the display device for display.
22. The method of claim 21, wherein the sample information includes the total number of samples and the test items for each sample; or, the sample information includes the number of samples per batch, the test items for each batch of samples, and each On-board time of batch samples;

    The reagent allocation information includes a correspondence relationship between each reagent unit and the type of reagent that is allocated, and the reagent type corresponds to the detection item.
23. The method according to claim 22, wherein the simulating the testing process of the sample based on the sample information and the reagent allocation information input by the user through the input device includes:

    According to the sample information and reagent allocation information input by the user through the input device, the detection sequence of all samples is prearranged;

    Simulate the testing process of all samples according to the testing sequence.
24. The method of claim 23, wherein the pre-arranged detection order of all samples includes:

    Pre-arrange the sampling time for all samples to start aspiration to get the detection order of all samples.
25. The method of claim 24, wherein simulating the testing process of all samples according to the testing sequence includes:

    Starting from the first sample, according to the sampling time, all samples are tested to test the corresponding test items.
26. The method according to claim 23, wherein the evaluation data includes whole-machine evaluation data and/or analysis module evaluation data, and the analysis module evaluation data is evaluation data of an analysis module where the reagent unit is located.
27. The method of claim 26, wherein the overall evaluation data includes a first total test time, a first average sample test time, a longest sample test time, and/or a first test speed.
28. The method according to claim 27, wherein the overall evaluation data is a first total test time, and the calculating the evaluation data according to the test process includes:

    During the testing process, record the test start time of the first sample and the test end time of the last sample to obtain the first test start time and the first test end time;

    The time difference between the first test start time and the first test end time is calculated to obtain the first total test time.
29. The method according to claim 27, wherein the whole machine evaluation data is a first average sample test time, and the calculating the evaluation data according to the test process includes:

    During the testing process, record the test start time and test end time of each sample;

    Calculate the test time of each sample according to the test start time and test end time of each sample;

    Calculate the sum of the test time of all samples to get the total test time;

    The average test time of each sample is calculated according to the total test time and the total number of samples or the number of samples in each batch to obtain the first average sample test time.
30. The method according to claim 27, wherein the whole machine evaluation data is the longest sample test time, and the calculating the evaluation data according to the test process includes:

    During the testing process, record the test start time and test end time of each sample;

    Calculate the test time of each sample according to the test start time and test end time of each sample;

    Obtain the longest test time from the test time of each sample to obtain the longest sample test time.
31. The method according to claim 27, wherein the overall evaluation data is a first test speed, and the calculating the evaluation data according to the test process includes:

    During the testing process, obtain the total number of test items for all samples;

    Record the test start time of the first sample and the test end time of the last sample to obtain the first test start time and the first test end time;

    Calculating the time difference between the first test start time and the first test end time to obtain a first total test time;

    Calculate the ratio of the total number of items to the first total test time to obtain the first test speed.
32. The method according to claim 26, wherein the analysis module evaluation data includes a second average sample test time, a second test speed, a second test start time, a second test end time, and/or a longest sample draw waiting time.
33. The method of claim 32, wherein the evaluation data of the analysis module is a second average sample test time, and the calculation of the evaluation data according to the test process includes:

    During the test, for the analysis module where the reagent unit is located, for each sample tested on the analysis module, record the test start time and test end time of the sample;

    Calculating the test time of each sample according to the test start time and the test end time;

    Calculate the sum of the test time to obtain the total test time;

    The average test time of each sample is calculated according to the total test time and the total number of samples tested on the analysis module to obtain a second average sample test time.
34. The method according to claim 32, wherein the second test start time is the time when the analysis module where the reagent unit is located starts to detect the first test item; the second test end time is the reagent The time when the analysis module where the unit is located completes the last test item; the calculation of the evaluation data according to the test process includes:

    During the test, the second test start time and/or the second test end time are recorded.
35. The method of claim 32, wherein the analysis module evaluation data is a second test speed, and the calculating the evaluation data according to the test process includes:

    During the test, for the analysis module where the reagent unit is located, obtain the total number of test items for which the sample detection is performed on the analysis module;

    Record the time when the analysis module starts to detect the first test item and the time to complete the last test item to obtain the second test start time and the second test end time;

    Calculating the time difference between the second test start time and the second test end time to obtain the second total test time of the analysis module;

    Calculate the ratio of the total number of times to the second total test time to obtain the second test speed.
36. The method of claim 21, further comprising: storing the evaluation data.
37. The method of claim 36, further comprising:

    Compare the evaluation data corresponding to the distribution information of at least two reagents;

    The comparison result is output to the display device for display.
38. A computer-readable storage medium, characterized by comprising a program, which can be executed by a processor to implement the method according to any one of claims 21 to 37.

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