CN113039439A - Sample analysis apparatus and method of evaluating reagent dispensing - Google Patents

Sample analysis apparatus and method of evaluating reagent dispensing Download PDF

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Publication number
CN113039439A
CN113039439A CN201980075452.7A CN201980075452A CN113039439A CN 113039439 A CN113039439 A CN 113039439A CN 201980075452 A CN201980075452 A CN 201980075452A CN 113039439 A CN113039439 A CN 113039439A
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sample
time
test
detection
testing
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林扬
鞠文涛
王俊
尹亮
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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Shenzhen Mindray Bio Medical Electronics Co Ltd
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G—PHYSICS
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Abstract

After a user inputs sample information and reagent distribution information, the sample analysis equipment can simulate a test process of a sample according to the sample information and the reagent distribution information, and accordingly calculates evaluation data for evaluating the distribution effect of the reagent distribution information and displays the evaluation data to the user, so that the user can know the distribution effect of the reagent distribution information according to the evaluation data, and the purpose of estimating the reagent distribution effect by the sample analysis equipment is achieved.

Description

Sample analysis apparatus and method of evaluating reagent dispensing Technical Field
The invention relates to the technical field of medical instruments, in particular to a sample analysis device and a reagent distribution evaluation method.
Background
Sample analyzers, such as biochemical analyzers, immunoassay analyzers, and the like, are commonly used in clinical laboratories to detect various analytical components of blood, urine, or other body fluids, and provide a basis for diagnosis of diseases and judgment of body functions. The device can realize the simultaneous reaction and detection of a plurality of samples and a plurality of items, has the advantages of high automation degree, high measurement speed, accurate measurement result and the like, and is widely applied to clinical examination.
In the process of analyzing a sample, a sample analyzer generally needs to mix a sample to be tested with a corresponding reagent according to a test item, and then complete the analysis of the sample according to a mixing result. Therefore, each sample analyzer is provided with a reagent unit for supplying a reagent required for the test, which is capable of rotationally positioning each reagent container containing the reagent to a corresponding reagent sucking site. For a sample analyzer with a plurality of reagent units, reagents need to be distributed to different reagent units when the sample analyzer is used, and different reagent distribution modes can directly influence evaluation indexes such as testing speed, working time and the like of the sample analyzer.
At present, the effect brought by different reagent distribution modes of a sample analyzer is mainly subjectively evaluated by an operator according to long-term use experience, and the influence of subjective factors is large.
Disclosure of Invention
The present invention generally provides a sample analysis apparatus and a reagent dispensing evaluation method to enable the sample analysis apparatus to evaluate the effect of reagent dispensing.
According to a first aspect, there is provided in one embodiment a sample analysis apparatus comprising an input device, an analysis device, a processor and a display device;
the analysis device is connected with the processor and is used for analyzing the sample, and the analysis device comprises at least two reagent units which are used for providing reagents for sample analysis;
the input device is connected with the processor and is used for detecting sample information and reagent distribution information input by a user and inputting the sample information and the reagent distribution information into the processor, wherein the reagent distribution information is information of reagents distributed on each reagent unit by the user;
the processor is used for simulating a test process of a sample according to the sample information and the reagent distribution information, calculating evaluation data according to the test process, and sending the evaluation data to the display device, wherein the evaluation data is used for evaluating the distribution effect of the reagent distribution information;
the display device is connected with the processor and used for displaying the evaluation data.
According to a second aspect, there is provided in an embodiment a method of assessing reagent dispensing, comprising:
simulating a test process of a sample according to sample information and reagent distribution information input by a user through an input device, wherein the reagent distribution information is information of reagents distributed on each reagent unit;
calculating evaluation data according to the test process, wherein the evaluation data is used for evaluating the distribution effect of the reagent distribution information;
and sending the evaluation data to a display device for displaying.
According to the sample analysis apparatus and the reagent dispensing evaluation method of the above embodiments, after the user inputs the sample information and the reagent dispensing information, the sample analysis apparatus can simulate the test process of the sample according to the sample information and the reagent dispensing information, and accordingly calculate the evaluation data for evaluating the dispensing effect of the reagent dispensing information, and display the evaluation data to the user. Thereby achieving the purpose of evaluating the effect of reagent dispensing by the sample analysis device.
Drawings
FIG. 1 is a schematic structural diagram of a sample analysis apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic diagram of a sample analysis device according to an embodiment of the present invention;
FIG. 3 is a schematic diagram of a sample analysis device according to another embodiment of the present invention;
FIG. 4 is a flow chart of a method of assessing reagent dispensing in one embodiment of the present invention;
FIG. 5 is a schematic view of an information entry interface according to the present invention;
FIG. 6 is a flow chart of a method of assessing reagent dispensing in one embodiment of the present invention;
FIG. 7 is a schematic view of another sample information entry interface in accordance with the present invention;
FIG. 8 is a schematic view of yet another sample information entry interface in accordance with the present invention;
FIG. 9 is a schematic view of a reagent dispensing information entry interface according to the present invention;
FIG. 10 is a flow chart of a method of assessing reagent dispensing in another embodiment of the present invention.
Detailed Description
The present invention will be described in further detail with reference to the following detailed description and accompanying drawings. The terms "connected" and "coupled" when used herein, unless otherwise indicated, include both direct and indirect connections (couplings).
The sample analysis apparatus may comprise a single unit (one analyzer) or a combination (at least two analyzers in cascade) of biochemical analyzers, immunological analyzers, etc. to perform biochemical, immunological, or biochemical and immunological analysis on the sample. The sample may be an analyte in serum, plasma or other human body fluids. The sample analysis device is generally composed of an analysis module, a sample introduction control unit, a processor, and the like. The analysis module comprises at least one reagent unit and is mainly used for analyzing the analytes in serum, plasma and other human body fluids; the sample injection control unit mainly controls the input, dispatching, transmission, positioning and recovery of the sample rack and automatically identifies the bar code information of the sample rack and the sample tube; the processor can realize the functions of data input, data output, detection result evaluation, quality control and the like of the sample analysis equipment.
For a single machine with a plurality of reagent units in an analysis module or a sample interconnection device with a plurality of reagent units formed by cascading a plurality of analysis modules, a user often distributes reagents to different reagent units according to different use requirements. In the process, different reagent distribution modes can affect important evaluation indexes of departments such as the testing speed of the whole machine, TAT time (time for completing the test) and the like.
The existing sample analysis equipment does not have the function of estimating the effect of reagent distribution, and for a reagent distribution mode, the effect needs to be evaluated through manual calculation, or the effect can be evaluated according to specific use conditions after the sample analysis equipment needs to be used for a period of time, and the evaluation is very easily influenced by subjective factors of users. With the diversification of customized demands of users, the increase of the number of interconnected analysis modules, the gradual increase of the capacity of reagent bins and other situations, the demand for estimating the reagent distribution effect is continuously enhanced, and users hope to estimate the current reagent distribution mode by sample analysis equipment to estimate whether the current reagent distribution mode can meet specific requirements or not, without manual calculation estimation, or the effect needs to be tested after the user actually uses the reagent for a period of time.
The scheme of the invention is provided in order to reduce the scenes which need to be manually estimated by the user to the maximum extent and ensure that the use effect after distribution meets the requirements to the maximum extent.
In the embodiment of the invention, as long as a user inputs the sample information and the reagent distribution information, the sample analysis equipment can simulate the test process of the sample according to the sample information and the reagent distribution information, calculate the evaluation data, and display the obtained evaluation data to the user, so that the user can know the distribution effect of the reagent distribution information through the evaluation data.
The embodiment of the invention provides sample analysis equipment, the structural schematic diagram of which is shown in fig. 1, the sample analysis equipment comprises an input device 1, an analysis device 2, a processor 3 and a display device 4, wherein the input device 1, the analysis device 2 and the display device 4 are respectively connected with the processor 3. Wherein the analysis device 2 is used for analyzing a sample, the analysis device 2 comprises at least two reagent units S for providing reagents for analyzing the sample.
Based on fig. 1, in a specific embodiment, the sample analysis apparatus may only comprise one analyzer, such as a biochemical analyzer or an immunological analyzer, the analysis device 2 of the sample analysis apparatus comprises one analysis module 21, the analysis module 21 may be a biochemical analysis module or an immunological analysis module, the analysis module 21 comprises at least two reagent units S, and the structural schematic diagram thereof can be seen in fig. 2. In another specific embodiment, the sample analyzer may comprise a combination of at least two analyzers, such as at least two biochemical analyzers, at least two immunological analyzers, or a combination of at least one biochemical analyzer and at least one immunological analyzer, the analyzing device 2 of the sample analyzer comprises at least two analyzing modules 21, the at least two analyzing modules 21 may be both biochemical analyzing modules or immunological analyzing modules, or may be partly biochemical analyzing modules and partly immunological analyzing modules, i.e. the types of the at least two analyzing modules 21 may be the same or different, wherein each analyzing module 21 comprises at least one reagent unit S, and the schematic structural diagram thereof can be seen in fig. 3.
In practical applications, the reagent units S may be disk-shaped reagent trays, and when at least two reagent units S are included in one analysis module 21, the reagent units S may be distributed as shown in fig. 2; the reagent units S may also be at least two coaxially arranged, for example, one analysis module 21 includes two reagent units S therein, and the two reagent units S respectively form coaxial inner and outer rings, i.e., form a double-ring structure.
With the sample analysis apparatuses of the various configurations described above, the input device 1 is configured to detect sample information and reagent dispensing information input by a user, which is information of a reagent dispensed by the user on each reagent unit S, and input the sample information and the reagent dispensing information to the processor 3. The processor 3 is configured to simulate a test process of the sample according to the sample information and the reagent dispensing information input by the user, calculate evaluation data according to the test process, and transmit the obtained evaluation data to the display device 4, the evaluation data being used to evaluate the dispensing effect of the reagent dispensing information. The display device 4 is used for displaying the evaluation data obtained by the processor 3.
In practice, the sample analysis apparatus may further comprise a memory, and the processor 3 stores the obtained evaluation data in the memory when receiving a storage instruction input by the user through the input device 1. Thus, the processor 3 can compare the evaluation data corresponding to at least two kinds of reagent dispensing information stored in the memory, and output the comparison result to the display device 4 for display. The user can know which reagent dispensing mode has better dispensing effect according to the comparison result so as to meet the current requirement.
Based on the sample analysis device of the above embodiment, an embodiment of the present invention further provides a reagent dispensing evaluation method, whose flowchart is shown in fig. 4, and the method may include the following steps:
step 101: sample information and reagent dispensing information are obtained.
When the user inputs the sample information and the reagent dispensing information through the input device 1, the processor 3 acquires the sample information and the reagent dispensing information. The sample information may include the total number of samples and the detection items of each sample; alternatively, the number of samples in each batch, the detection items of each batch of samples, and the machine time of each batch of samples may be used. The reagent distribution information is information of the reagent distributed by the user on each reagent unit, and the reagent distribution information may include a corresponding relationship between each reagent unit S and a distributed reagent type, where the reagent type corresponds to the detection item in the sample information.
Step 102: and simulating the test process of the sample.
The processor 3 simulates the test procedure of the sample according to the sample information and the reagent dispensing information input by the user through the input device 1.
Step 103: and calculating evaluation data.
The processor 3 calculates evaluation data for evaluating the dispensing effect of the reagent dispensing information input by the user according to the simulated test course of the sample. The evaluation data can be used for evaluating the overall effect of the sample analysis equipment, evaluating the effect of each analysis module in the sample analysis equipment, and evaluating the overall effect and the effect of each analysis module simultaneously. The calculated evaluation data may be data related to factors such as time or speed, for example, the test duration of each sample, the total duration of all samples tested, the average test duration of a single sample, the test speed of a whole machine, the test speed of a single analysis module, and the like may be calculated by simulating the test process of the samples (all samples in the sample information input by the user). For sample analysis equipment comprising a plurality of reagent units, different reagent distribution modes have different influences on the scheduling efficiency, the testing efficiency and the like of a sample; by calculating the evaluation data, the corresponding effect of a specific reagent distribution mode (the reagent distribution mode corresponding to the reagent distribution information input by the user) can be known in advance, and reference is provided for the user to distribute the reagent.
Step 104: and displaying the evaluation data.
After the processor 3 calculates the evaluation data, the evaluation data is transmitted to the display device 4 to be displayed.
According to the sample analysis equipment and the reagent distribution evaluation method provided by the embodiment of the invention, when a user wants to know the use effect of the sample analysis equipment in a certain reagent distribution mode, the sample information and the reagent distribution information can be input through the input device, at this time, the processor can simulate the test process of the sample according to the information and calculate the evaluation data, then the evaluation data is displayed to the user, the user can know the distribution effect of the reagent distribution information according to the evaluation data, the function of estimating the reagent distribution effect of the sample analysis equipment is realized, the user can conveniently check the reagent distribution effect under various conditions in advance, and the user can conveniently select a proper reagent distribution strategy.
In the embodiment of the invention, the evaluation of the reagent distribution effect can be the evaluation of the whole sample analysis device, the evaluation of each reagent unit in the sample analysis device, or the evaluation of the reagent distribution effect and the reagent units simultaneously. The following describes the solution of the present invention in detail by taking the evaluation of the effect of the whole sample analyzer as an example.
Here, taking the example that the sample analysis apparatus includes 2 reagent units (S1 and S2, respectively), the 2 reagent units may be located in two analysis modules 21, respectively.
The sample analysis device provides an information input interface for a user when the reagent distribution effect is estimated, and the information input interface is displayed through the display device 4 when the user needs to estimate the reagent distribution effect. Fig. 5 illustrates an information entry interface that can include a sample information entry window at which a user can enter sample information and a reagent dispensing information entry window at which reagent dispensing information is entered.
FIG. 6 is a flow chart of a method for assessing reagent dispensing in one embodiment of the present invention, which may include the steps of, as shown in FIG. 6:
step 201: sample information is obtained.
The user inputs sample information through the input device 1 according to the information entry interface displayed on the display device 4, and at this time, the processor 3 acquires the sample information.
For example, as shown in fig. 5, the user may input the total number of samples, such as 10 samples, in the "total number" option, and then respectively input the detection items of each sample of the 10 samples in the "detection items" of the "sample" item. The name of the test package may be inputted into the test items, for example, five items of hepatitis B are inputted into the sample No. 1 and the sample No. 4, or each test item may be inputted, for example, ACTH (adrenocorticotropic hormone) is inputted into the sample No. 2, and Anti-HCV (hepatitis C antibody), HIV (AIDS virus) and Anti-TP (syphilis) are inputted into the sample No. 3. For convenience of operation, a selection menu of detection items may be provided for each sample, and the user may select a detection item from the menu, for example, fig. 7 shows a schematic view of another sample information entry interface, a corresponding function menu of "selection detection items" may be provided for each sample, and when the user clicks the menu, a selectable detection item list pops up, for example, a menu of "selection detection items" of sample No. 1 is clicked, the popped up detection item list includes detection items such as ACTH, Anti-HCV, HIV, Anti-TP, etc., the user selects a desired detection item from the list, and then clicks a "ok" key in the detection item list, so as to select a detection item. After the sample information of each sample is input, the user clicks a 'confirm' function key in the sample information entry window to finish the input of the sample information.
In practical application, the sample information may be input by batch, where the sample information may include the number of samples in each batch, the detection items of the samples in each batch, and the on-machine time of the samples in each batch, and the user only needs to input the information of the samples in each batch. For example, fig. 8 shows another sample information entry window, where the user can enter the number of the 1 st batch of samples, the detection item, and the time on machine in the "number of 1 st batch", the detection item "and the time on machine" items, for example, respectively enter "10", "hepatitis b five items", and "9: 00", then there are 10 samples in the 1 st batch, the detection item of each sample is hepatitis b five items, and the sample is on machine at 9: 00. If there are multiple batches of samples, these three information entry items for batches of samples, batch 2, batch 3, etc., may be added via the "add" function key. And finally, clicking a 'confirm' key to finish the input of the sample information.
Step 202: reagent dispensing information is obtained.
The user inputs reagent dispensing information via the input device 1 according to the information entry interface displayed on the display device 4, and at this time, the processor 3 acquires the reagent dispensing information.
For example, in the information entry interface shown in fig. 5, a user may open a reagent dispensing information entry window for entry of reagent dispensing information. Fig. 9 shows a reagent dispensing information entry interface, and a user may input a reagent type to be dispensed in "reagent type" corresponding to the respective reagent cells S1 and S2, according to the test items in the entered sample information, the reagent type corresponding to the test items in the sample information, the reagent type being determined as long as the test items are determined, and the test items may be directly input in "reagent type" for convenience. For example, if the user only enters the 1 st batch of samples in the sample information entry window shown in fig. 8, and the input detection item is "five items of hepatitis b", the user may assign the five items of hepatitis b to S1 and S2, respectively, for example, the user inputs HBeAg, HBsAg, and Anti-HBc in S1, the user inputs Anti-HBs, and Anti-HBe in S2, and the user clicks the "ok" key to complete the input of the reagent assignment information. If the user enters a plurality of samples in the sample information entry window shown in fig. 8, or enters sample information of a plurality of samples in the sample information entry window shown in fig. 5, the user needs to assign the test items included in all the samples to S1 and S2.
In practical application, a user can conveniently enter reagent distribution information, information entry errors are avoided, in the reagent distribution information entry window shown in fig. 8, as in fig. 7, function menus of "selecting reagent types" are respectively set for S1 and S2, when the user clicks the menus, a selectable detection item list pops up, only detection items input by the user in the sample information entry window are displayed in the list, and thus, the user only needs to select the detection items allocated to S1 or S2 in the detection item list as required.
Step 203: and calculating the evaluation data of the whole machine.
After receiving the sample information and the reagent distribution information input by the user through the input device 1, the processor 3 simulates a test process of the sample according to the sample information and the reagent distribution information, and calculates complete machine evaluation data of the sample analysis equipment according to the test process, wherein the complete machine evaluation data may include a first total test time, a first average sample test time, a longest sample test time and/or a first test speed.
Specifically, the processor 3 may calculate the overall evaluation data of the sample analysis device according to the following steps a1 to C1:
step A1: and (4) arranging a sample detection sequence in advance.
After receiving the sample information and the reagent dispensing information input by the user through the input device 1, the processor 3 pre-arranges the sample drawing time for starting the sample drawing of all samples according to the sample information and the reagent dispensing information, so as to determine the detection sequence of all samples in the sample information. For example, the user inputs sample information and reagent distribution information of 40 samples (or four sample racks, each sample rack is loaded with 10 samples), the sample information of each sample includes detection item information, and the input sample information of 40 samples has a sequence, which can be one of the reference factors for pre-arranging the sample detection sequence; in addition, the reagent distributed by each reagent unit can be determined through the reagent distribution information input by the user, the detection items executable by the analysis module where each reagent unit is located can also be determined, and the sample detection sequence can be pre-arranged according to the matching condition of the detection items executable by each analysis module and the detection item information of the sample; for example, if it is determined that the first analysis module can perform the first test item according to the reagent dispensing information, the order in which the samples including the first test item are sent to the first analysis module for testing is pre-arranged.
Step B1: and simulating the test process of the sample.
After the processor 3 arranges the sample sucking time in advance, the test process of the sample can be simulated according to the sample sucking time. Specifically, starting from the first sample, the processor 3 may simulate the test process of detecting the respective corresponding detection items of all samples according to the working process of the sample analysis device during the normal sample test according to the pre-arranged sample sucking time or sequence until the detection of all samples is completed. For example, the user inputs sample information and reagent allocation information of 40 samples, and determines a target analysis module of each sample according to the reagent allocation information, for example, the detection items of samples 1 to 20 are first detection items, the detection items of samples 21 to 40 are second detection items, and the first analysis module can execute the first detection items, and the second analysis module can execute the second detection items according to the reagent allocation information, so that the target analysis module of samples 1 to 20 can be the first analysis module, and the target analysis module of samples 21 to 40 is the second analysis module, and the simulation process can include: scanning the samples 1-20 in sequence, dispatching the samples 1-20 to a first analysis module for sample suction and detection, and executing detection of a first detection item; and scanning the samples 21-40 in sequence, dispatching the samples 21-40 to a second analysis module for sample suction, and executing detection of a second detection item.
Step C1: and calculating the complete machine evaluation data according to the test process of the sample.
The processor 3 calculates the complete machine evaluation data according to the test process of the simulated samples, for example, the processor 3 can estimate the time from the completion of the bar code scanning to the obtaining of the detection result of the sample for each sample, the time from the sample sucking to the obtaining of the result of the corresponding detection item for each sample, and the like.
In the process of calculating the evaluation data of the whole machine, the processor 3 may use, for each sample, the time when the sample starts to perform barcode scanning as the detection start time of the sample, and use the time when the sample is tested and the detection result is obtained as the detection end time of the sample according to the estimation function. Alternatively, for each sample, the sample aspirating time when the first detection item is detected may be set as the detection start time of the sample.
Specifically, for the first total testing time, the processor 3 records the detection start time of the first sample and the detection end time of the last sample in the testing process of the simulation sample to obtain the first testing start time T1 and the first testing end time T2, and then calculates the time difference between T1 and T2, that is, the first total testing time. In practical applications, the overall evaluation data may further include the first test start time and/or the first test end time.
In practical applications, when calculating the first total test time, the time when the simulation process is started after the user inputs the sample information and the reagent dispensing information may be used as the first test start time.
For the first average sample testing time, the processor 3 records the detection start time and the detection end time of each sample in the testing process of the simulation sample, calculates the testing time of each sample according to the detection start time and the detection end time of each sample, then calculates the sum of the testing times of all samples to obtain the total testing time, and then calculates the average testing time of each sample according to the total testing time and the total number of samples or the number of each batch of samples to obtain the first average sample testing time.
For example, if the total number of samples is 5, the processor 3 records the detection start time and the detection end time of each sample during the test of the simulated samples, and calculates the test time of these 5 samples as t1, t2, t3, t4 and t5, respectively, then the first average sample test time can be calculated according to the formula (t1+ t2+ t3+ t4+ t 5)/5. If the number of samples in each batch is given, the total number of samples can be obtained by summing the number of samples in each batch, and the first average sample test time can be obtained in the same way.
For the longest sample testing time, the processor 3 records the detection start time and the detection end time of each sample during the testing process of the simulated samples, calculates the testing time of each sample according to the detection start time and the detection end time of each sample, then obtains the longest testing time from the testing times, and takes the longest testing time as the longest sample testing time.
For the first testing speed, the processor 3 obtains the total number Q of items detected for all samples during the testing process of the simulation samples, records the detection start time of the first sample and the detection end time of the last sample to obtain a first testing start time T1 and a first testing end time T2, then calculates the time difference between T1 and T2 to obtain a first total testing time T, and finally calculates the ratio of Q to T to obtain a first testing speed Q/T.
The complete machine evaluation data can also comprise shortest sample testing time, the processor 3 records the detection starting time and the detection ending time of each sample in the test process of the simulation samples, calculates the testing time of each sample according to the detection starting time and the detection ending time of each sample, then obtains the shortest testing time from the testing times, and takes the shortest testing time as the shortest sample testing time.
Step 204: and displaying the evaluation data of the whole machine.
After the processor 3 calculates the complete machine evaluation data, the complete machine evaluation data is transmitted to the display device 4 for display. Specifically, the display device 4 may display the complete machine evaluation data in the form of a graph.
After the processor 3 sends the complete machine evaluation data to the display device 4 for displaying, the following steps can be executed:
step 205: and storing the evaluation data of the whole machine.
The processor 3 stores the complete machine evaluation data. Specifically, the input device 1 detects an operation of saving the complete machine evaluation data by the user, generates a saving instruction according to the operation, and then sends the saving instruction to the processor 3. When receiving the saving instruction, the processor 3 saves the complete machine evaluation data in the memory, so that a user can conveniently view the complete machine evaluation data at any time or further analyze the evaluation data.
The above method embodiments are illustrated by evaluating the effect of the complete sample analysis apparatus. In practical application, the effects of each analysis module in the sample analysis equipment can be evaluated, or the effects of the whole machine and each analysis module can be evaluated simultaneously.
Fig. 10 is a flowchart of a reagent dispensing evaluation method according to another embodiment of the present invention, which is described by taking an example of evaluating the reagent dispensing effect of an analysis module in which each reagent unit is located in a sample analysis apparatus, and as shown in fig. 10, the method may include the following steps:
step 301 and step 302 are the same as step 201 and step 202, respectively, and are not described again here.
Step 303: the computational analysis module evaluates the data.
After receiving the sample information and the reagent dispensing information input by the user through the input device 1, the processor 3 simulates a test process of the sample according to the sample information and the reagent dispensing information, and calculates evaluation data of an analysis module of the sample analysis apparatus (i.e., evaluation data of an analysis module in which the reagent unit is located) according to the test process, where the evaluation data of the analysis module may include a second average sample test time, a second test speed, a second test start time, a second test end time, and/or a maximum sample suction waiting time.
Specifically, the processor 3 may calculate the analysis module evaluation data of the sample analysis device according to the following steps a2 to C2:
the specific procedures of step a2 and step B2 are the same as step a1 and step B1, respectively.
Step C2: and calculating evaluation data of the analysis module according to the test process of the sample.
The processor 3 calculates the analysis module evaluation data from the test procedure of the simulated sample.
Specifically, the second test start time is a time when the analysis module where the reagent unit is located starts to detect the first detection item, or a sample sucking time when the detection of the first detection item starts, and the time can be recorded by the processor 3 in the test process of the analog sample. The second test end time is the time when the analysis module where the reagent unit is located completes the last detection item, and the time can also be recorded by the processor 3 in the test process of the simulation sample. Wherein said analysis module is for an analysis module. The sample sucking waiting time is the time from the end of the sample sucking to the beginning of the next sample sucking on the same analysis module, and can be recorded by the processor 3 in the test process of the simulation sample, and after the test on the analysis module is completed, the longest time is taken from the recorded time as the longest sample sucking waiting time. In practice, the processor 3 may also record the time point of the longest waiting time of the sample suction.
For the second average sample testing time, the processor 3 records, for each sample tested on each analysis module (i.e. the analysis module where the reagent unit is located) during the test of the simulated sample, the testing start time k1 and the testing end time k2 of the sample, where the testing start time k1 may be the time when the analysis module starts to test the first testing item of the sample on the analysis module, or may be the sample sucking time when the analysis module starts to test the sample. Then, the processor 3 calculates the test time k of each sample according to k1 and k2, i.e. k is k2-k 1; then, calculating the sum of the test time k of all samples to obtain total test time Y; and calculating the average test time of each sample according to the Y and the total number of the samples detected on the analysis module to obtain the second average sample test time.
For example, the 3 samples tested at analysis module M1 were A, B and C, and for sample A, processor 3 recorded the time k1 at which A began testing at M1AAnd time k2 for ending detectionAThen calculating the test time k of AA＝k1 A-k2 A(ii) a Similarly, the test time k of samples B and C can be obtainedBAnd kC(ii) a Then, the total test time Y ═ k of the 3 samples A, B and C was determinedA+k B+k C(ii) a Finally, a second average sample test time Y 'of these 3 samples is obtained from Y' ═ Y/3.
For the second testing speed, in the testing process of the simulated sample, the processor 3 obtains, for each analysis module, the total number R of times of the detection items for performing sample detection on the analysis module, records the time when the analysis module starts detecting the first detection item and the time when the analysis module finishes the last detection item, obtains a second testing start time M1 and a second testing end time M2, and then calculates the time difference between M1 and M2, obtains a second total testing time M for the analysis module, that is, M is M2-M1; and finally, calculating the ratio of R to M to obtain a second test speed R/M.
Step 304: the display analysis module evaluates the data.
Similar to step 204, after the processor 3 calculates the evaluation data of the analysis module, the evaluation data of the analysis module is sent to the display device 4 for display. Specifically, the display device 4 may display the analysis module evaluation data in the form of a graph.
After sending the analysis module evaluation data to the display device 4 for display, the processor 3 may also perform similar steps 305 as in fig. 6:
step 305: the storage analysis module evaluates the data.
In practical application, when the processor 3 simulates a test process of a sample, the complete machine evaluation data and the analysis module evaluation data can be simultaneously calculated, and then the obtained complete machine evaluation data and the obtained analysis module evaluation data are sent to the display device 4, and the display device 4 can simultaneously display the complete machine evaluation data and the analysis module evaluation data in a chart form.
In practical application, after the evaluation data of the whole machine and/or the evaluation data of the analysis module are stored, the reagent distribution evaluation method further comprises the following steps a to c:
step a: evaluation data is acquired.
The memory has stored evaluation data for a plurality of different reagent dispensing formats (i.e. reagent dispensing information), and the processor 3 may retrieve from the memory the evaluation data for each of at least two reagent dispensing formats. For example, the sample analysis apparatus may display a comparative analysis menu on the display device, and the user may select the two reagent dispensing methods from the comparative analysis menu by using the input device 1 when the user wants to compare the reagent dispensing method 1 and the reagent dispensing method 2 stored in the memory, and at this time, the input device 1 generates a comparative instruction and transmits the comparative instruction to the processor 3, and when the processor 3 receives the comparative instruction, the processor acquires evaluation data corresponding to each of the reagent dispensing method 1 and the reagent dispensing method 2 from the memory according to the comparative instruction. Alternatively, the user may compare the current reagent dispensing method with the reagent dispensing method stored in the memory.
Step b: and comparing the evaluation data.
After the processor 3 acquires the evaluation data corresponding to the at least two kinds of reagent distribution information, the two kinds of evaluation data are compared to obtain a comparison result. For example, the first average sample test time and the longest sample test time in the reagent distribution pattern 1 are respectively compared with the first average sample test time and the longest sample test time in the reagent distribution pattern 2, so that the reagent distribution pattern with the shortest first average sample test time and the reagent distribution pattern with the shortest longest sample test time can be obtained.
Step c: and displaying the comparison result.
After the processor 3 obtains the comparison result, the comparison result is output to the display device 4 to be displayed. In practical application, the evaluation data to be compared and the comparison result can be displayed at the same time, and can also be displayed in a form of a graph.
According to the sample analysis equipment and the reagent distribution evaluation method provided by the embodiment of the invention, a user can input sample information and reagent distribution information through an input device, at the moment, a processor can simulate the test process of a sample according to the information and calculate the evaluation data of the whole machine and/or the evaluation data of an analysis module, then the evaluation data of the whole machine and/or the evaluation data of the analysis module are displayed to the user, the user can know the use effect of the reagent distribution information on the whole machine and/or the use effect on the analysis module where the reagent unit is located according to the data, the function of the sample analysis equipment for estimating the reagent distribution effect is realized, the reagent distribution effect can be estimated when the sample analysis equipment is installed for the first time, and the user can conveniently know or check the reagent distribution effect under various conditions in advance. Furthermore, the calculated overall evaluation data and/or the calculated evaluation data of the analysis module can be stored in a memory, so that a user can conveniently view the data at any time or further analyze the data. In addition, the whole machine evaluation data and/or the analysis module evaluation data corresponding to different reagent distribution information can be compared, so that a user can conveniently select a proper reagent distribution strategy.
The scheme proposed by the invention can be applied to the following scenes at least:
(1) and upgrading a plurality of single machines into interconnected sample analysis equipment.
In such a scenario, a user only has a plurality of individual sample analyzers, and for a certain requirement, such as increasing the testing speed, the plurality of sample analyzers need to be interconnected and upgraded to a sample analysis device having a plurality of analysis modules. And because the user only knows the reagent distribution data of each single machine, if the reagent distribution condition of each analysis module of the interconnected equipment is still consistent with that of the original analysis module, whether the use requirement of the user can be met is unknown, and under the condition, the scheme of the invention can provide the estimation of the reagent distribution effect for the user so that the user knows the use effect of the reagent distribution in advance.
(2) After a period of use, a device in which a plurality of sample analyzers are cascaded may wish to upgrade or replace the sample analyzers.
After a user has already performed reagent distribution on each original reagent unit, when at least one of the sample analyzers is upgraded or replaced with a new sample analyzer, whether the new cascade equipment can meet the original requirements or not, or whether the new cascade equipment can also meet the requirements such as completion in normal time after a certain test amount is added, and in such a scenario, the scheme of the present invention can be adopted for estimation in advance.
Reference is made herein to various exemplary embodiments. However, those skilled in the art will recognize that changes and modifications may be made to the exemplary embodiments without departing from the scope hereof. For example, the various operational steps, as well as the components used to perform the operational steps, may be implemented in differing ways depending upon the particular application or consideration of any number of cost functions associated with operation of the system (e.g., one or more steps may be deleted, modified or incorporated into other steps).
Additionally, as will be appreciated by one skilled in the art, the principles herein may be reflected in a computer program product on a computer readable storage medium, which is pre-loaded with computer readable program code. Any tangible, non-transitory computer-readable storage medium may be used, including magnetic storage devices (hard disks, floppy disks, etc.), optical storage devices (CD-ROMs, DVDs, Blu Ray disks, etc.), flash memory, and/or the like. These computer program instructions may be loaded onto a general purpose computer, special purpose computer, or other programmable data processing apparatus to produce a machine, such that the instructions which execute on the computer or other programmable data processing apparatus create means for implementing the functions specified. These computer program instructions may also be stored in a computer-readable memory that can direct a computer or other programmable data processing apparatus to function in a particular manner, such that the instructions stored in the computer-readable memory produce an article of manufacture including means for implementing the function specified. The computer program instructions may also be loaded onto a computer or other programmable data processing apparatus to cause a series of operational steps to be performed on the computer or other programmable apparatus to produce a computer implemented process such that the instructions which execute on the computer or other programmable apparatus provide steps for implementing the functions specified.
While the principles herein have been illustrated in various embodiments, many modifications of structure, arrangement, proportions, elements, materials, and components particularly adapted to specific environments and operative requirements may be employed without departing from the principles and scope of the present disclosure. The above modifications and other changes or modifications are intended to be included within the scope of this document.
The foregoing detailed description has been described with reference to various embodiments. However, one skilled in the art will recognize that various modifications and changes may be made without departing from the scope of the present disclosure. Accordingly, the disclosure is to be considered in an illustrative and not a restrictive sense, and all such modifications are intended to be included within the scope thereof. Also, advantages, other advantages, and solutions to problems have been described above with regard to various embodiments. However, the benefits, advantages, solutions to problems, and any element(s) that may cause any element(s) to occur or become more pronounced are not to be construed as a critical, required, or essential feature or element of any or all the claims. As used herein, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, system, article, or apparatus. Furthermore, the term "coupled," and any other variation thereof, as used herein, refers to a physical connection, an electrical connection, a magnetic connection, an optical connection, a communicative connection, a functional connection, and/or any other connection.
Those skilled in the art will recognize that many changes may be made to the details of the above-described embodiments without departing from the underlying principles of the invention. Accordingly, the scope of the invention should be determined from the following claims.

Claims (38)

  1. A sample analysis apparatus comprising input means, analysis means, a processor and display means;
    the analysis device is connected with the processor and is used for analyzing the sample, and the analysis device comprises at least two reagent units which are used for providing reagents for sample analysis;
    the input device is connected with the processor and is used for detecting sample information and reagent distribution information input by a user and inputting the sample information and the reagent distribution information into the processor, wherein the reagent distribution information is information of reagents distributed on each reagent unit;
    the processor is used for simulating a test process of a sample according to the sample information and the reagent distribution information, calculating evaluation data according to the test process, and sending the evaluation data to the display device, wherein the evaluation data is used for evaluating the distribution effect of the reagent distribution information;
    the display device is connected with the processor and used for displaying the evaluation data.
  2. The sample analysis apparatus of claim 1, wherein the analysis device comprises an analysis module comprising at least two of the reagent units.
  3. The sample analysis apparatus of claim 1, wherein the analysis device comprises at least two analysis modules, each of the analysis modules comprising at least one of the reagent units.
  4. The sample analysis apparatus according to claim 2 or 3, wherein the sample information includes a total number of samples and a detection item of each sample; or, the sample information includes the number of each batch of samples, the detection items of each batch of samples, and the on-machine time of each batch of samples;
    the reagent distribution information includes a correspondence between each reagent unit and a reagent type to be distributed, the reagent type corresponding to the detection item.
  5. The sample analysis device according to claim 4, wherein the processor, when simulating the test process of the samples based on the sample information and the reagent dispensing information, is specifically configured to pre-order the detection order of all the samples based on the sample information and the reagent dispensing information, and simulate the test process of all the samples based on the pre-ordered detection order.
  6. The sample analysis apparatus according to claim 5, wherein the processor is specifically configured to pre-arrange a sample drawing time at which a sample drawing is started for all samples according to the sample information and the reagent dispensing information, and simulate a test procedure for detecting respective corresponding detection items for all samples according to the sample drawing time from a first sample.
  7. The sample analysis apparatus of claim 5, wherein the assessment data comprises overall assessment data and/or analysis module assessment data, the analysis module assessment data being assessment data of an analysis module in which the reagent unit is located.
  8. The sample analysis apparatus of claim 7, wherein the overall evaluation data comprises a first total test time, a first average sample test time, a longest sample test time, and/or a first test speed.
  9. The sample analyzer of claim 8, wherein the overall evaluation data is a first total test time, and the processor is configured to record a detection start time of a first sample and a detection end time of a last sample during the test process when calculating the evaluation data according to the test process, to obtain a first test start time and a first test end time, and to calculate a time difference between the first test start time and the first test end time, to obtain the first total test time.
  10. The sample analysis apparatus of claim 9, wherein the overall evaluation data further comprises the first test start time and/or the first test end time.
  11. The sample analysis device of claim 8, wherein the overall evaluation data is a first average sample test time, and the processor, when calculating the evaluation data from the test procedure, is specifically configured to: in the testing process, the detection starting time and the detection ending time of each sample are recorded, the testing time of each sample is calculated according to the detection starting time and the detection ending time of each sample, the sum of the testing time of all samples is obtained, the average testing time of each sample is calculated according to the sum of the testing time of all samples and the total number of the samples or the number of each batch of samples, and the first average sample testing time is obtained.
  12. The sample analysis device of claim 8, wherein the overall evaluation data is a longest sample test time, and the processor, when calculating evaluation data from the test procedure, is specifically configured to: in the testing process, the detection starting time and the detection ending time of each sample are recorded, the testing time of each sample is calculated according to the detection starting time and the detection ending time of each sample, and the longest testing time is obtained from the testing time of each sample to obtain the longest testing time of the sample.
  13. The sample analysis apparatus of claim 8, wherein the overall evaluation data is a first test speed, and the processor, when calculating evaluation data from the test procedure, is specifically configured to: in the testing process, the total number of items of the testing items of all samples is obtained, the testing starting time of the first sample and the testing ending time of the last sample are recorded, the first testing starting time and the first testing ending time are obtained, the time difference between the first testing starting time and the first testing ending time is calculated, the first total testing time is obtained, and the ratio of the total number of items to the first total testing time is calculated, so that the first testing speed is obtained.
  14. The sample analysis device of claim 7, wherein the analysis module evaluation data comprises a second average sample test time, a second test speed, a second test start time, a second test end time, and/or a maximum wait time for a draw.
  15. The sample analysis device of claim 14, wherein the analysis module evaluation data is a second average sample test time, and the processor, when calculating evaluation data from the test procedure, is specifically configured to: in the testing process, for each sample detected on the analysis module where the reagent unit is located, recording the detection start time and the detection end time of the sample, calculating the testing time of each sample according to the detection start time and the detection end time of each sample, solving the sum of the testing times, and calculating the average testing time of each sample according to the sum of the testing times and the total number of the samples detected on the analysis module to obtain the second average sample testing time.
  16. The sample analyzing apparatus according to claim 14, wherein, for the analyzing module in which the reagent unit is located, the second test start time is a time when the analyzing module starts to detect the first test item, and the second test end time is a time when the analyzing module completes the last test item;
    the processor is specifically configured to record the second test start time and/or the second test end time during the test.
  17. The sample analysis device of claim 14, wherein the analysis module evaluation data is a second test speed, and the processor, when calculating evaluation data from the test procedure, is specifically configured to: in the testing process, for an analysis module where a reagent unit is located, the total number of times of detection items for sample detection on the analysis module is obtained, the time for the analysis module to start detecting a first detection item and the time for completing a last detection item are recorded, a second test start time and a second test end time are obtained, the time difference between the second test start time and the second test end time is calculated, a second total test time of the analysis module is obtained, and the ratio of the total number of times to the second total test time is calculated, so that a second test speed is obtained.
  18. Sample analysis device as claimed in claim 1, characterized in that the display means are in particular adapted to display the evaluation data in the form of a graph.
  19. The sample analysis apparatus of claim 1, further comprising a memory, wherein the processor stores the assessment data in the memory upon receiving a save instruction input by a user via the input device.
  20. The sample analyzing apparatus of claim 19, wherein the processor is further configured to compare the evaluation data corresponding to each of the at least two reagent dispensing information stored in the memory, and output the comparison result to the display device for display.
  21. A method for assessing reagent dispensing, comprising:
    simulating a test process of a sample according to sample information and reagent distribution information input by a user through an input device, wherein the reagent distribution information is information of reagents distributed on each reagent unit;
    calculating evaluation data according to the test process, wherein the evaluation data is used for evaluating the distribution effect of the reagent distribution information;
    and sending the evaluation data to a display device for displaying.
  22. The method of claim 21, wherein the sample information includes a total number of samples and a detection item per sample; or, the sample information includes the number of each batch of samples, the detection items of each batch of samples, and the on-machine time of each batch of samples;
    the reagent distribution information includes a correspondence between each reagent unit and a reagent type to be distributed, the reagent type corresponding to the detection item.
  23. The method of claim 22, wherein simulating a test procedure for the sample based on the sample information and the reagent dispensing information input by the user via the input device comprises:
    pre-arranging the detection sequence of all samples according to the sample information and the reagent distribution information input by a user through an input device;
    and simulating the test process of all samples according to the detection sequence.
  24. The method of claim 23, wherein the pre-arranging the order of detection of all samples comprises:
    and pre-arranging the sample suction time for starting the sample suction of all samples to obtain the detection sequence of all samples.
  25. The method of claim 24, wherein simulating the testing process of all samples according to the detection sequence comprises:
    and starting from the first sample, simulating the test process of detecting the detection items corresponding to all samples according to the sample sucking time.
  26. The method of claim 23, wherein the assessment data comprises overall assessment data and/or analysis module assessment data, the analysis module assessment data being assessment data of an analysis module in which the reagent unit is located.
  27. The method of claim 26, wherein the overall evaluation data includes a first total test time, a first average sample test time, a longest sample test time, and/or a first test speed.
  28. The method of claim 27, wherein the overall evaluation data is a first total test time, and wherein the calculating evaluation data based on the test procedure comprises:
    recording the detection starting time of a first sample and the detection ending time of a last sample in the test process to obtain a first test starting time and a first test ending time;
    and calculating the time difference between the first test starting time and the first test ending time to obtain the first total test time.
  29. The method of claim 27, wherein said overall evaluation data is a first average sample test time, and said calculating evaluation data from said test procedure comprises:
    recording the detection start time and the detection end time of each sample in the test process;
    calculating the testing time of each sample according to the detection starting time and the detection ending time of each sample;
    calculating the sum of the test time of all samples to obtain total test time;
    and calculating the average testing time of each sample according to the total testing time and the total number of the samples or the number of the samples in each batch to obtain the first average sample testing time.
  30. The method of claim 27, wherein the overall evaluation data is a longest sample test time, and wherein calculating evaluation data from the test procedure comprises:
    recording the detection start time and the detection end time of each sample in the test process;
    calculating the testing time of each sample according to the detection starting time and the detection ending time of each sample;
    and obtaining the longest test time from the test time of each sample to obtain the longest sample test time.
  31. The method of claim 27, wherein the overall evaluation data is a first test speed, and wherein calculating evaluation data based on the test procedure comprises:
    in the testing process, acquiring the total number of items of the detection items of all samples;
    recording the detection start time of a first sample and the detection end time of a last sample to obtain a first test start time and a first test end time;
    calculating the time difference between the first test starting time and the first test ending time to obtain first total test time;
    and calculating the ratio of the total number of the items to the first total testing time to obtain a first testing speed.
  32. The method of claim 26, wherein the analysis module evaluation data comprises a second average sample test time, a second test speed, a second test start time, a second test end time, and/or a maximum wait time for a draw.
  33. The method of claim 32, wherein said analyzing module evaluation data is a second average sample test time, and said calculating evaluation data from said test procedure comprises:
    in the testing process, for each sample detected on the analysis module where the reagent unit is located, recording the detection start time and the detection end time of the sample;
    calculating the testing time of each sample according to the detection starting time and the detection ending time;
    calculating the sum of the test time to obtain the total test time;
    and calculating the average testing time of each sample according to the total testing time and the total number of the samples detected on the analysis module to obtain the second average sample testing time.
  34. The method of claim 32, wherein the second test start time is a time when the analysis module in which the reagent unit is located starts to detect the first test item; the second test ending time is the time for completing the last detection item by the analysis module where the reagent unit is located; the calculating evaluation data according to the test procedure comprises:
    and recording the second test starting time and/or the second test ending time in the test process.
  35. The method of claim 32, wherein said analyzing module evaluating data is a second test speed, said calculating evaluation data from said test procedure comprising:
    in the test process, acquiring the total times of detection items for sample detection on an analysis module of the reagent unit;
    recording the time when the analysis module starts to detect the first detection item and the time when the analysis module finishes the last detection item to obtain a second test starting time and a second test ending time;
    calculating the time difference between the second test starting time and the second test ending time to obtain a second total test time of the analysis module;
    and calculating the ratio of the total times to the second total testing time to obtain a second testing speed.
  36. The method of claim 21, further comprising: storing the evaluation data.
  37. The method of claim 36, further comprising:
    comparing the evaluation data respectively corresponding to the at least two kinds of reagent distribution information;
    and outputting the comparison result to the display device for displaying.
  38. A computer-readable storage medium, characterized by comprising a program executable by a processor to implement the method of any one of claims 21 to 37.
CN201980075452.7A 2019-01-07 2019-01-07 Sample analysis apparatus and method of evaluating reagent dispensing Pending CN113039439A (en)

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