WO2020141177A1 - Liquid nicotine formulation comprising water-immiscible solvents - Google Patents

Liquid nicotine formulation comprising water-immiscible solvents Download PDF

Info

Publication number
WO2020141177A1
WO2020141177A1 PCT/EP2019/087195 EP2019087195W WO2020141177A1 WO 2020141177 A1 WO2020141177 A1 WO 2020141177A1 EP 2019087195 W EP2019087195 W EP 2019087195W WO 2020141177 A1 WO2020141177 A1 WO 2020141177A1
Authority
WO
WIPO (PCT)
Prior art keywords
water
percent
weight
nicotine formulation
liquid nicotine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2019/087195
Other languages
English (en)
French (fr)
Inventor
Robert Emmett
Jean-Pierre Schaller
Aline VUARNOZ-BIZE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Philip Morris Products SA
Original Assignee
Philip Morris Products SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philip Morris Products SA filed Critical Philip Morris Products SA
Priority to UAA202101822A priority Critical patent/UA128585C2/uk
Priority to KR1020217020778A priority patent/KR102930095B1/ko
Priority to EP19831770.3A priority patent/EP3905898B1/en
Priority to CN201980079943.9A priority patent/CN113163847B/zh
Priority to JP2021531580A priority patent/JP2022515021A/ja
Priority to BR112021010222-1A priority patent/BR112021010222A2/pt
Priority to ES19831770T priority patent/ES2980261T3/es
Priority to US17/418,928 priority patent/US20220053817A1/en
Priority to MX2021007623A priority patent/MX427496B/es
Priority to PL19831770.3T priority patent/PL3905898T3/pl
Publication of WO2020141177A1 publication Critical patent/WO2020141177A1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A24B15/241—Extraction of specific substances
    • A24B15/243—Nicotine
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/32—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by acyclic compounds
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/05—Devices without heating means
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/10—Devices using liquid inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/42—Cartridges or containers for inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/46—Shape or structure of electric heating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams

Definitions

  • the invention relates to a liquid nicotine formulation for use in an aerosol-generating system.
  • the invention also relates to a cartridge for an aerosol-generating system comprising the liquid nicotine formulation and an aerosol-generating system comprising the liquid nicotine formulation and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • Aerosol-generating systems for delivering nicotine to a user that comprise an atomiser configured to generate an inhalable aerosol from a liquid nicotine formulation are known.
  • Some known aerosol-generating systems comprise a thermal atomiser such as an electric heater that is configured to heat and vaporise the liquid nicotine formulation to generate an aerosol.
  • Other known aerosol-generating systems comprise a non-thermal atomiser that is configured to generate an aerosol from the liquid nicotine formulation using, for example, impinging jet, ultrasonic or vibrating mesh technologies.
  • Typical liquid nicotine formulations for use in aerosol generating systems comprise glycerine, propylene glycol and water as solvents.
  • pulmonary delivery of the inhalable aerosol generated from the liquid nicotine formulation is important for user palatability and satisfaction. Nicotine adsorption through the pulmonary alveoli is rapid and efficient. By contrast, nicotine adsorption in the upper airways is slower and less efficient. Nicotine adsorption in the upper airways may also undesirably be perceived by a user as having a sensorial harshness and induce mouth and throat irritation.
  • liquid nicotine formulation for use in an aerosol generating system that that enables generation of an aerosol providing improved nicotine satisfaction to a user compared to typical liquid nicotine formulations.
  • liquid nicotine formulation for use in an aerosol-generating system that enables generation of an aerosol having improved lung deposition characteristics and nicotine retention compared to aerosols generated from typical liquid nicotine formulations.
  • a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: at least one of water and one or more water-miscible solvents; one or more partially water-soluble, water- immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • a cartridge for use in an aerosol-generating system the cartridge containing a liquid nicotine formulation comprising: at least one of water and one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • an aerosol generating system comprising: a liquid nicotine formulation comprising: at least one of water and one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml; and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: at least one of water and one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • a cartridge for use in an aerosol-generating system the cartridge containing a liquid nicotine formulation comprising: at least one of water and one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • an aerosol generating system comprising: a liquid nicotine formulation comprising: at least one of water and one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5; and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • liquid nicotine formulation describes a liquid formulation comprising nicotine.
  • the term“nicotine” describes nicotine, nicotine base or a nicotine salt.
  • the amounts of nicotine recited herein are the amount of free base nicotine or amount of protonated nicotine, respectively.
  • the term“water-miscible solvent” describes a compound other than water or an organic acid that is liquid at 20°C and mixes with water in all proportions to form a homogenous solution.
  • the term“partially water- soluble, water-immiscible solvent” describes a compound that is liquid at 20°C and has a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml.
  • the term“partially water-soluble, water-immiscible solvent” describes a compound that is liquid at 20°C and has a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5.
  • water-insoluble, water-immiscible solvent describes a compound that is liquid at 20°C and has a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • water- insoluble, water-immiscible solvent describes a compound that is liquid at 20°C and has a partition coefficient (log P) at 20°C of greater than about 5.
  • water solubility values recited herein are the water solubility measured based on the preliminary test of OECD (1995), Test No. 105: Water Solubility, OECD Guidelines for the Testing of Chemicals, Section 1 , OECD Publishing, Paris, https://doi.org/10.1787/9789264069589-en.
  • OECD Water Solubility
  • OECD Guidelines for the Testing of Chemicals Section 1 , OECD Publishing, Paris, https://doi.org/10.1787/9789264069589-en.
  • increasing volumes of distilled water are added at 20°C to 0.1 g of the sample (solid substances must be pulverized) in a 10 ml glass-stoppered measuring cylinder.
  • the substance is an acid
  • the sample is added to the distilled water in the first step.
  • the solubility When the solubility is low, a long time may be required to dissolve a substance and at least 24 hours should be allowed. If, after 24 hours, the substance is still not dissolved, the measuring cylinder is placed for at 40°C in an ultrasound bath for 15 minutes and another 24 hours allowed (up to a maximum of 96 hours). If the substance is still not dissolved, the solubility is considered to be below the limit value or not soluble.
  • partition coefficient (log P) values recited herein are the octanol/water partition coefficient (log Pow) measured in accordance with: OECD (1995), Test No. 107: Partition Coefficient (n-octanol/water): Shake Flask Method, OECD Guidelines for the Testing of Chemicals, Section 1 , OECD Publishing, Paris, https://doi.org/10.1787/9789264069626-en (for values in the range log Pow between -2 and 4); OECD (2004), Test No.
  • Inclusion of a combination of at least one of water and one or more water-miscible solvents, one or more partially water-soluble, water-immiscible solvents and one or more water insoluble, water-immiscible solvents in the liquid nicotine formulation according to the invention advantageously enables generation of an inhalable aerosol providing improved nicotine satisfaction to a user compared to aerosols generated from typical liquid nicotine formulations.
  • inclusion of a combination of at least one of water and one or more water-miscible solvents, one or more partially water-soluble, water-immiscible solvents and one or more water insoluble, water-immiscible solvents in the liquid nicotine formulation according to the invention advantageously enables generation of an inhalable aerosol having improved lung deposition characteristics and nicotine retention compared to aerosols generated from typical liquid nicotine formulations.
  • the liquid nicotine formulation according to the invention when used in an aerosol-generating system the liquid nicotine formulation according to the invention generates an inhalable aerosol comprising dual phase particles or droplets comprising an aqueous or water-miscible phase and a water- immiscible phase. This advantageously reduces nicotine adsorption in the upper airways and enhances pulmonary nicotine delivery and retention.
  • the improvement in pulmonary nicotine delivery and retention is believed to be due to coating or enveloping of the aqueous or water-miscible phase by the water immiscible phase. This is believed to reduce nicotine evaporation and adsorption in the upper airways.
  • the liquid nicotine formulation may comprise natural nicotine or synthetic nicotine.
  • the liquid nicotine formulation may have a nicotine content of greater than or equal to about 0.5 percent by weight.
  • the liquid nicotine formulation has a nicotine content of greater than or equal to about 1 percent by weight. More preferably, the liquid nicotine formulation has a nicotine content of greater than or equal to about 1.5 percent by weight.
  • the liquid nicotine formulation may have a nicotine content of less than or equal to about 10 percent by weight.
  • the liquid nicotine formulation may have a nicotine content of less than or equal to about 8 percent by weight.
  • the liquid nicotine formulation has a nicotine content of less than or equal to about 5 percent by weight. More preferably, the liquid nicotine formulation has a nicotine content of less than or equal to about 3 percent by weight.
  • the liquid nicotine formulation may have a nicotine content of between about 0.5 percent by weight and about 10 percent by weight.
  • the liquid nicotine formulation may have a nicotine content of between about 0.5 percent by weight and about 8 percent by weight, between about 0.5 percent by weight and about 5 percent by weight or between about 0.5 percent by weight and about 3 percent by weight.
  • the liquid nicotine formulation has a nicotine content of between about 1 percent by weight and about 10 percent by weight.
  • the liquid nicotine formulation may have a nicotine content of between about 1 percent by weight and about 8 percent by weight, between about 1 percent by weight and about 5 percent by weight or between about 1 percent by weight and about 3 percent by weight.
  • the liquid nicotine formulation has a nicotine content of between about 1.5 percent by weight and about 10 percent by weight.
  • the liquid nicotine formulation may have a nicotine content of between about 1.5 percent by weight and about 8 percent by weight, between about 1.5 percent by weight and about 5 percent by weight or between about 1.5 percent by weight and about 3 percent by weight.
  • the liquid nicotine formulation comprises at least one of water and one or more water- miscible solvents. That is, the liquid nicotine comprises water or one or more miscible solvents or both water and one or more miscible solvents.
  • the liquid nicotine formulation may have a total water and water-miscible solvent content of greater than or equal to about 50 percent by weight or greater than or equal to about 55 percent by weight.
  • the liquid nicotine formulation has a total water and water-miscible solvent content of greater than or equal to about 60 percent by weight. More preferably, the liquid nicotine formulation has a total water and water-miscible solvent content of greater than or equal to 65 percent by weight.
  • the liquid nicotine formulation may have a total water and water-miscible solvent content of greater than or equal to about 70 percent by weight, greater than or equal to about 75 percent by weight, greater than or equal to about 80 percent by weight or greater than or equal to about 85 percent by weight.
  • the liquid nicotine formulation comprises water
  • the water may advantageously help to dissolve and stabilise polar components and ionic components of the liquid nicotine formulation.
  • the liquid nicotine formulation comprises water
  • the liquid nicotine formulation has a water content of greater than or equal to about 5 percent by weight. More preferably, the liquid nicotine formulation has a water-content of greater than or equal to about 10 percent by weight.
  • the liquid nicotine formulation may have a water content of greater than or equal to about 15 percent by weight, greater than or equal to about 20 percent by weight, greater than or equal to about 25 percent by weight, greater than or equal to about 30 percent by weight or greater than or equal to about 35 percent by weight.
  • the liquid nicotine formulation comprises water
  • the liquid nicotine formulation may have a water content of less than or equal to about 90 percent by weight.
  • the liquid nicotine formulation comprises water
  • the liquid nicotine formulation has a water content of less than or equal to about 85 percent by weight. More preferably, the liquid nicotine formulation has a water content of less than or equal to about 80 percent by weight.
  • the liquid nicotine formulation may have a water content of less than or equal to about 75 percent by weight, less than or equal to about 70 percent by weight or less than or equal to about 65 percent by weight.
  • the liquid nicotine formulation may have a water content of between about 5 percent by weight and about 90 percent by weight.
  • the liquid nicotine formulation has a water content of between about 5 percent by weight and about 85 percent by weight.
  • the liquid nicotine formulation may have a water content of between about 5 percent by weight and about 80 percent by weight, between about 5 percent by weight and about 75 percent by weight, between about 5 percent by weight and about 70 percent by weight or between about 5 percent by weight and about 65 percent by weight.
  • the liquid nicotine formulation may have a water content of between about 10 percent by weight and about 90 percent by weight. More preferably, the liquid nicotine formulation has a water content of between about 10 percent by weight and about 85 percent by weight. For example, the liquid nicotine formulation may have a water content of between about 10 percent by weight and about 80 percent by weight, between about 10 percent by weight and about 75 percent by weight, between about 10 percent by weight and about 70 percent by weight or between about 10 percent by weight and about 65 percent by weight. ln embodiments in which the liquid nicotine formulation comprises water, the liquid nicotine formulation may have a water content of between about 15 percent by weight and about 90 percent by weight or between about 15 percent by weight and about 85 percent by weight.
  • the liquid nicotine formulation may have a water content of between about 15 percent by weight and about 80 percent by weight, between about 15 percent by weight and about 75 percent by weight, between about 15 percent by weight and about 70 percent by weight or between about 15 percent by weight and about 65 percent by weight.
  • the liquid nicotine formulation may have a water content of between about 20 percent by weight and about 90 percent by weight or between about 20 percent by weight and about 85 percent by weight.
  • the liquid nicotine formulation may have a water content of between about 20 percent by weight and about 80 percent by weight, between about 20 percent by weight and about 75 percent by weight, between about 20 percent by weight and about 70 percent by weight or between about 20 percent by weight and about 65 percent by weight.
  • the liquid nicotine formulation may have a water content of between about 25 percent by weight and about 90 percent by weight or between about 25 percent by weight and about 85 percent by weight.
  • the liquid nicotine formulation may have a water content of between about 25 percent by weight and about 80 percent by weight, between about 25 percent by weight and about 75 percent by weight, between about 25 percent by weight and about 70 percent by weight or between about 25 percent by weight and about 65 percent by weight.
  • the liquid nicotine formulation may have a water content of between about 30 percent by weight and about 90 percent by weight or between about 30 percent by weight and about 85 percent by weight.
  • the liquid nicotine formulation may have a water content of between about 30 percent by weight and about 80 percent by weight, between about 30 percent by weight and about 75 percent by weight, between about 30 percent by weight and about 70 percent by weight or between about 30 percent by weight and about 65 percent by weight.
  • the liquid nicotine formulation may have a water content of between about 35 percent by weight and about 90 percent by weight or between about 35 percent by weight and about 85 percent by weight.
  • the liquid nicotine formulation may have a water content of between about 35 percent by weight and about 80 percent by weight, between about 35 percent by weight and about 75 percent by weight, between about 35 percent by weight and about 70 percent by weight or between about 35 percent by weight and about 65 percent by weight.
  • the one or more water-miscible solvents may advantageously help to dissolve and stabilise polar components and ionic components of the liquid nicotine formulation.
  • the liquid nicotine formulation comprises one or more water- miscible solvents
  • the liquid nicotine formulation has a water-miscible solvent content of greater than or equal to about 5 percent by weight. More preferably, the liquid nicotine formulation has a water-miscible solvent content of greater than or equal to about 10 percent by weight.
  • the liquid nicotine formulation may have a water-miscible solvent content of greater than or equal to about 15 percent by weight, greater than or equal to about 20 percent by weight or greater than or equal to about 25 percent by weight.
  • the liquid nicotine formulation may have a water-miscible solvent content of less than or equal to about 80 percent by weight or less than or equal to about 75 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible solvents
  • the liquid nicotine formulation has a water-miscible solvent content of less than or equal to about 70 percent by weight. More preferably, the liquid nicotine formulation has a water-miscible solvent content of less than or equal to about 60 percent by weight.
  • the liquid nicotine formulation may have a water-miscible solvent content of less than or equal to about 50 percent by weight or less than or equal to about 40 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible solvents
  • the liquid nicotine formulation has a water-miscible solvent content of between about 5 percent by weight and about 70 percent by weight.
  • the liquid nicotine formulation may have a water-miscible solvent content of between about 5 percent by weight and about 60 percent by weight, between about 5 percent by weight and about 50 percent by weight or between about 5 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation has a water-miscible solvent content of between about 10 percent by weight and about 70 percent by weight.
  • the liquid nicotine formulation may have a water-miscible solvent content of between about 10 percent by weight and about 60 percent by weight, between about 10 percent by weight and about 50 percent by weight or between about 10 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible solvents
  • the liquid nicotine formulation may have a water-miscible solvent content of between about 15 percent by weight and about 70 percent by weight, between about 15 percent by weight and about 60 percent by weight, between about 15 percent by weight and about 50 percent by weight or between about 15 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation may have a water-miscible solvent content of between about 20 percent by weight and about 70 percent by weight, between about 20 percent by weight and about 60 percent by weight, between about 20 percent by weight and about 50 percent by weight or between about 20 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation may have a water-miscible solvent content of between about 25 percent by weight and about 70 percent by weight, between about 25 percent by weight and about 60 percent by weight, between about 25 percent by weight and about 50 percent by weight or between about 25 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible solvents
  • the one or more water-miscible solvents are one or more water- miscible polyhydric alcohols.
  • water-miscible polyhydric alcohol describes a polyhydric alcohol that is liquid at 20°C and mixes with water in all proportions to form a homogenous solution.
  • a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water- immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • a cartridge for use in an aerosol-generating system the cartridge containing a liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water- immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • an aerosol-generating system comprising: a liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml; and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • an aerosol-generating system comprising: a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols; one or more partially water-soluble, water- immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • a cartridge for use in an aerosol-generating system the cartridge containing a liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • an aerosol-generating system comprising: a liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5; and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • a liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5; and an atomiser configured to generate an aerosol from
  • the liquid nicotine formulation comprises one or more water- miscible polyhydric alcohols
  • the liquid nicotine formulation has a water-miscible polyhydric alcohol content of greater than or equal to about 5 percent by weight. More preferably, the liquid nicotine formulation has a water-miscible polyhydric alcohol content of greater than or equal to about 10 percent by weight.
  • the liquid nicotine formulation may have a water-miscible polyhydric alcohol content of greater than or equal to about 15 percent by weight, greater than or equal to about 20 percent by weight or greater than or equal to about 25 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible polyhydric alcohols
  • the liquid nicotine formulation may have a water-miscible polyhydric alcohol content of less than or equal to about 80 percent by weight or less than or equal to about 75 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible polyhydric alcohols
  • the liquid nicotine formulation has a water-miscible polyhydric alcohol content of less than or equal to about 70 percent by weight. More preferably, the liquid nicotine formulation has a water-miscible polyhydric alcohol content of less than or equal to about 60 percent by weight.
  • the liquid nicotine formulation may have a water- miscible polyhydric alcohol content of less than or equal to about 50 percent by weight or less than or equal to about 40 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible polyhydric alcohols
  • the liquid nicotine formulation has a water-miscible polyhydric alcohol content of between about 5 percent by weight and about 70 percent by weight.
  • the liquid nicotine formulation may have a water-miscible polyhydric alcohol content of between about 5 percent by weight and about 60 percent by weight, between about 5 percent by weight and about 50 percent by weight or between about 5 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation has a water-miscible polyhydric alcohol content of between about 10 percent by weight and about 70 percent by weight.
  • the liquid nicotine formulation may have a water-miscible polyhydric alcohol content of between about 10 percent by weight and about 60 percent by weight, between about 10 percent by weight and about 50 percent by weight or between about 10 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible polyhydric alcohols
  • the liquid nicotine formulation may have a water-miscible polyhydric alcohol content of between about 15 percent by weight and about 70 percent by weight, between about 15 percent by weight and about 60 percent by weight, between about 15 percent by weight and about 50 percent by weight or between about 15 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation may have a water-miscible polyhydric alcohol content of between about 20 percent by weight and about 70 percent by weight, between about 20 percent by weight and about 60 percent by weight, between about 20 percent by weight and about 50 percent by weight or between about 20 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation may have a water-miscible polyhydric alcohol content of between about 25 percent by weight and about 70 percent by weight, between about 25 percent by weight and about 60 percent by weight, between about 25 percent by weight and about 50 percent by weight or between about 25 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible polyhydric alcohols
  • the one or more water-miscible polyhydric alcohols are selected from the group consisting of 1 ,3-butanediol, glycerine, propylene glycol, and triethylene glycol.
  • the one or more water-miscible polyhydric alcohols are selected from the group consisting of glycerine and propylene glycol.
  • the one or more water-miscible polyhydric alcohols are selected from the group consisting of vegetable glycerine and propylene glycol.
  • a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water- soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water- soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • a cartridge for use in an aerosol-generating system the cartridge containing a liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohol selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water- soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • a cartridge for use in an aerosol-generating system the cartridge containing a liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • an aerosol-generating system comprising: a liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5; and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • a liquid nicotine formulation comprising: at least one of water and one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immisc
  • the liquid nicotine formulation comprises one or more water- miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol
  • the liquid nicotine formulation may have a combined glycerine and propylene glycol content of less than or equal to about 80 percent by weight or less than or equal to about 75 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol
  • the liquid nicotine formulation has a combined glycerine and propylene glycol content of less than or equal to about 70 percent by weight. More preferably, the liquid nicotine formulation has a combined glycerine and propylene glycol content of less than or equal to about 60 percent by weight.
  • the liquid nicotine formulation may have a combined glycerine and propylene glycol content of less than or equal to about 50 percent by weight or less than or equal to about 40 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol
  • the liquid nicotine formulation may have a combined glycerine and propylene glycol content of between about 5 percent by weight and about 80 percent by weight or between about 5 percent by weight and about 75 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol
  • the liquid nicotine formulation has a combined glycerine and propylene glycol content of between about 5 percent by weight and about 70 percent by weight.
  • the liquid nicotine formulation may have a combined glycerine and propylene glycol content of between about 5 percent by weight and about 60 percent by weight, between about 5 percent by weight and about 50 percent by weight or between about 5 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol
  • the liquid nicotine formulation may have a combined glycerine and propylene glycol content of between about 10 percent by weight and about 80 percent by weight or between about 10 percent by weight and about 75 percent by weight.
  • the liquid nicotine formulation has a combined glycerine and propylene glycol content of between about 10 percent by weight and about 70 percent by weight.
  • the liquid nicotine formulation may have a combined glycerine and propylene glycol content of between about 10 percent by weight and about 60 percent by weight, between about 10 percent by weight and about 50 percent by weight or between about 10 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation comprises one or more water- miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol
  • the liquid nicotine formulation may have a combined glycerine and propylene glycol content of between about 15 percent by weight and about 80 percent by weight, between about 15 percent by weight and about 75 percent by weight, between about 15 percent by weight and about 70 percent by weight, between about 15 percent by weight and about 60 percent by weight, between about 15 percent by weight and about 50 percent by weight or between about 15 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation may have a combined glycerine and propylene glycol content of between about 20 percent by weight and about 80 percent by weight, between about 20 percent by weight and about 75 percent by weight, between about 20 percent by weight and about 70 percent by weight, between about 20 percent by weight and about 60 percent by weight, between about 20 percent by weight and about 50 percent by weight or between about 20 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation may have a combined glycerine and propylene glycol content of between about 25 percent by weight and about 80 percent by weight, between about 15 percent by weight and about 75 percent by weight, between about 25 percent by weight and about 70 percent by weight, between about 25 percent by weight and about 60 percent by weight, between about 25 percent by weight and about 50 percent by weight or between about 25 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation comprises water and one or more water-miscible solvents.
  • a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: water; one or more water-miscible solvents; one or more partially water- soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • a cartridge for use in an aerosol-generating system the cartridge containing a liquid nicotine formulation comprising: water; one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • an aerosol-generating system comprising: a liquid nicotine formulation comprising: water; one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml; and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: water; one or more water-miscible solvents; one or more partially water- soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • a cartridge for use in an aerosol-generating system the cartridge containing a liquid nicotine formulation comprising: water; one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • an aerosol-generating system comprising: a liquid nicotine formulation comprising: water; one or more water-miscible solvents; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5; and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • the liquid nicotine formulation may have a combined water and water-miscible solvent content of greater than or equal to about 50 percent by weight or greater than or equal to about 55 percent by weight.
  • the liquid nicotine formulation has a combined water and water-miscible solvent content of greater than or equal to about 60 percent by weight. More preferably, the liquid nicotine formulation has a combined water and water-miscible solvent content of greater than or equal to 65 percent by weight.
  • the liquid nicotine formulation may have a combined water and water-miscible solvent content of greater than or equal to about 70 percent by weight, greater than or equal to about 75 percent by weight, greater than or equal to about 80 percent by weight or greater than or equal to about 85 percent by weight.
  • the liquid nicotine formulation comprises water and one or more water- miscible polyhydric alcohols.
  • a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • a cartridge for use in an aerosol-generating system the cartridge containing a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water- immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • an aerosol-generating system comprising: a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols; one or more partially water- soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml; and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • a cartridge for use in an aerosol-generating system the cartridge containing a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • an aerosol-generating system comprising: a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols; one or more partially water- soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5; and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols; one or more partially water- soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5; and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • the liquid nicotine formulation comprises water and one or more water-miscible polyhydric alcohols
  • the liquid nicotine formulation may have a combined water and water-miscible polyhydric alcohol content of greater than or equal to about 50 percent by weight or greater than or equal to about 55 percent by weight.
  • the liquid nicotine formulation comprises water and one or more water-miscible polyhydric alcohols
  • the liquid nicotine formulation has a combined water and water-miscible polyhydric alcohol content of greater than or equal to about 60 percent by weight. More preferably, the liquid nicotine formulation has a combined water and water- miscible polyhydric alcohol content of greater than or equal to 65 percent by weight.
  • the liquid nicotine formulation may have a combined water and water-miscible polyhydric alcohol content of greater than or equal to about 70 percent by weight, greater than or equal to about 75 percent by weight, greater than or equal to about 80 percent by weight or greater than or equal to about 85 percent by weight.
  • the liquid nicotine formulation comprises water and one or more water- miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol.
  • a liquid nicotine formulation for use in an aerosol-generating system, the liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water- immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • a cartridge for use in an aerosol-generating system the cartridge containing a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • an aerosol-generating system comprising: a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml; and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml; and one or more water insoluble, water-i
  • an aerosol-generating system comprising: a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • a cartridge for use in an aerosol-generating system the cartridge containing a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of
  • an aerosol-generating system comprising: a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5; and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • a liquid nicotine formulation comprising: water; one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol; one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5; and one or more water insoluble, water-immiscible solvents a having a
  • the liquid nicotine formulation comprises water and one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol
  • the liquid nicotine formulation may have a combined water, glycerine and propylene glycol content of greater than or equal to about 50 percent by weight or greater than or equal to about 55 percent by weight.
  • the liquid nicotine formulation comprises water and one or more water-miscible polyhydric alcohols selected from the group consisting of glycerine and propylene glycol
  • the liquid nicotine formulation has a combined water, glycerine and propylene glycol content of greater than or equal to about 60 percent by weight.
  • the liquid nicotine formulation has a combined water, glycerine and propylene glycol content of greater than or equal to 65 percent by weight.
  • the liquid nicotine formulation may have a combined water, glycerine and propylene glycol content of greater than or equal to about 70 percent by weight, greater than or equal to about 75 percent by weight, greater than or equal to about 80 percent by weight or greater than or equal to about 85 percent by weight.
  • the liquid nicotine formulation has a glycerine content of greater than or equal to about 5 percent by weight.
  • the liquid nicotine formulation has a glycerine content of greater than or equal to about 6 percent by weight.
  • the liquid nicotine formulation may have a glycerine content of greater than or equal to about 7 percent by weight or greater than or equal to about 8 percent by weight.
  • the liquid nicotine formulation may have a glycerine content of less than or equal to about 80 percent by weight or less than or equal to about 75 percent by weight.
  • the liquid nicotine formulation has a glycerine content of less than or equal to about 70 percent by weight. More preferably, the liquid nicotine formulation has a glycerine content of less than or equal to about 60 percent by weight. For example, the liquid nicotine formulation may have a glycerine content of less than or equal to about 50 percent by weight or less than or equal to about 40 percent by weight.
  • the liquid nicotine formulation has a glycerine content of between about 5 percent by weight and about 70 percent by weight.
  • the liquid nicotine formulation may have a glycerine content of between about 5 percent by weight and about 60 percent by weight, between about 5 percent by weight and about 50 percent by weight or between about
  • the liquid nicotine formulation has a glycerine content of between about
  • the liquid nicotine formulation may have a glycerine content of between about 6 percent by weight and about 60 percent by weight, between about 6 percent by weight and about 50 percent by weight or between about 6 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation may have a glycerine content of between about 7 percent by weight and about 70 percent by weight, between about 7 percent by weight and about 60 percent by weight, between about 7 percent by weight and about 50 percent by weight or between about 7 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation may have a glycerine content of between about 8 percent by weight and about 70 percent by weight, between about 8 percent by weight and about 60 percent by weight, between about 8 percent by weight and about 50 percent by weight or between about 8 percent by weight and about 40 percent by weight.
  • the liquid nicotine formulation comprises water-immiscible solvents.
  • water- immiscible solvent describes a compound that is liquid at 20°C and has a water solubility at 20°C of less than or equal to about 100 mg/ml.
  • water- immiscible solvent describes a compound that is liquid at 20°C and has a partition coefficient (log P) at 20°C of greater than or equal to about 0.05.
  • the liquid nicotine formulation comprises one or more partially water-soluble, water-immiscible solvents having a water solubility at 20°C of between about 20 mg/ml and about 100 mg/ml and one or more water insoluble, water-immiscible solvents having a water solubility at 20°C of less than or equal to about 5 mg/ml.
  • the liquid nicotine formulation comprises one or more partially water-soluble, water-immiscible solvents having a partition coefficient (log P) at 20°C of between about 0.05 and about 0.5 and one or more water insoluble, water- immiscible solvents a having a partition coefficient (log P) at 20°C of greater than about 5.
  • the water-immiscible solvents may advantageously help to dissolve and stabilise non polar components of the liquid nicotine formulation.
  • the water-immiscible solvents may reduce the hygroscopicity of an aerosol generated from the liquid nicotine formulation when used in an aerosol-generating system. This may advantageously reduce or prevent increases in the particle or droplet size of the aerosol when inhaled by a user as a result of adsorption of water in the respiratory tract.
  • the liquid nicotine formulation has a total water-immiscible solvent content of greater than or equal to about 2 percent by weight.
  • total water-immiscible solvent content describes the combined partially water-soluble, water-immiscible solvent content and water-insoluble solvent content of the liquid nicotine formulation.
  • the liquid nicotine formulation may have a total water-immiscible solvent content of greater than or equal to about 4 percent by weight, greater than or equal to about 6 percent by weight or greater than or equal to about 8 percent by weight.
  • the liquid nicotine formulation may have a total water-immiscible solvent content of less than or equal to about 40 percent by weight. Preferably, the liquid nicotine formulation has a total water-immiscible solvent content of less than or equal to about 35 percent by weight. For example, the liquid nicotine formulation may have a total water-immiscible solvent content of less than or equal to about 30 percent by weight, less than or equal to about 25 percent by weight, less than or equal to about 20 percent by weight or less than or equal to about 15 percent by weight.
  • the liquid nicotine formulation has a total water-immiscible solvent content of between about 2 percent by weight and about 35 percent by weight.
  • the liquid nicotine formulation may have a total water-immiscible solvent content of between about 2 percent by weight and about 30 percent by weight, between about 2 percent by weight and about 25 percent by weight, between about 2 percent by weight and about 20 percent by weight or between about 2 percent by weight and about 15 percent by weight.
  • the liquid nicotine formulation may have a total water-immiscible solvent content of between about 4 percent by weight and about 35 percent by weight.
  • the liquid nicotine formulation may have a total water-immiscible solvent content of between about 4 percent by weight and about 30 percent by weight, between about 4 percent by weight and about 25 percent by weight, between about 4 percent by weight and about 20 percent by weight or between about 4 percent by weight and about 15 percent by weight.
  • the liquid nicotine formulation may have a total water-immiscible solvent content of between about 6 percent by weight and about 35 percent by weight.
  • the liquid nicotine formulation may have a total water-immiscible solvent content of between about 6 percent by weight and about 30 percent by weight, between about 6 percent by weight and about 25 percent by weight, between about 6 percent by weight and about 20 percent by weight or between about 6 percent by weight and about 15 percent by weight.
  • the liquid nicotine formulation may have a total water-immiscible solvent content of between about 8 percent by weight and about 35 percent by weight.
  • the liquid nicotine formulation may have a total water-immiscible solvent content of between about 8 percent by weight and about 30 percent by weight, between about 8 percent by weight and about 25 percent by weight, between about 8 percent by weight and about 20 percent by weight or between about 8 percent by weight and about 15 percent by weight.
  • the liquid nicotine formulation has a partially water-soluble, water-immiscible solvent content of greater than or equal to about 0.5 percent by weight. More preferably, the liquid nicotine formulation has a partially water-soluble, water-immiscible solvent content of greater than or equal to about 1 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of greater than or equal to about 2 percent by weight, greater than or equal to about 4 percent by weight, greater than or equal to about 6 percent by weight, greater than or equal to about 7 percent by weight or greater than or equal to about 8 percent by weight.
  • the liquid nicotine formulation has a partially water-soluble, water-immiscible solvent content of less than or equal to about 30 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of less than or equal to about 25 percent by weight, less than or equal to about 20 percent by weight or less than or equal to about 15 percent by weight.
  • the liquid nicotine formulation has a partially water-soluble, water-immiscible solvent content of between about 0.5 percent by weight and about 30 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of between about 0.5 percent by weight and about 25 percent by weight, between about 0.5 percent by weight and about 20 percent by weight or between about 0.5 percent by weight and about 15 percent by weight.
  • the liquid nicotine formulation has a partially water-soluble, water- immiscible solvent content of between about 1 percent by weight and about 30 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of between about 1 percent by weight and about 25 percent by weight, between about 1 percent by weight and about 20 percent by weight or between about 1 percent by weight and about 15 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of between about 2 percent by weight and about 30 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of between about 2 percent by weight and about 25 percent by weight, between about 2 percent by weight and about 20 percent by weight or between about 2 percent by weight and about 15 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of between about 4 percent by weight and about 30 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of between about 4 percent by weight and about 25 percent by weight, between about 4 percent by weight and about 20 percent by weight or between about 4 percent by weight and about 15 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of between about 6 percent by weight and about 30 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of between about 6 percent by weight and about 25 percent by weight, between about 6 percent by weight and about 20 percent by weight or between about 6 percent by weight and about 15 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of between about 7 percent by weight and about 30 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of between about 7 percent by weight and about 25 percent by weight, between about 7 percent by weight and about 20 percent by weight or between about 7 percent by weight and about 15 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of between about 8 percent by weight and about 30 percent by weight.
  • the liquid nicotine formulation may have a partially water-soluble, water-immiscible solvent content of between about 8 percent by weight and about 25 percent by weight, between about 8 percent by weight and about 20 percent by weight or between about 8 percent by weight and about 15 percent by weight.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent nicotine content of the liquid nicotine formulation may be greater than or equal to about 0.75.
  • the weight percent partially water-soluble, water-immiscible solvent content of the liquid nicotine formulation may be at least about 0.75 times the weight percent nicotine content of the liquid nicotine formulation.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent nicotine content of the liquid nicotine formulation is greater than or equal to about 1.
  • the ratio of the weight percent partially water-soluble, water- immiscible solvent content to the weight percent nicotine content of the liquid nicotine formulation may be greater than or equal to about 1.25, greater than or equal to about 1.5 or greater than or equal to about 1.75.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent nicotine content of the liquid nicotine formulation may be less than or equal to about 20.
  • the weight percent partially water-soluble, water-immiscible solvent content of the liquid nicotine formulation may be less than or equal to 20 times the weight percent nicotine content of the liquid nicotine formulation.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent nicotine content of the liquid nicotine formulation is less than or equal to about 18.
  • the ratio of the weight percent partially water-soluble, water- immiscible solvent content to the weight percent nicotine content of the liquid nicotine formulation may be less than or equal to about 16, less than or equal to about 14 or less than or equal to about 12.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent nicotine content of the liquid nicotine formulation may be between about 0.75 and about 20, between about 0.75 and about 18, between about 0.75 and about 16, between about 0.75 and about 14 or between about 0.75 and about 12.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent nicotine content of the liquid nicotine formulation is between about 1 and about 20, between about 1 and about 18, between about 1 and about 16, between about 1 and about 14 or between about 1 and about 12.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1.25 and about 20, between about 1.25 and about 18, between about 1.25 and about 16, between about 1.25 and about 14 or between about 1.25 and about 12.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1.5 and about 20, between about 1.5 and about 18, between about 1.5 and about 16, between about 1.5 and about 14 or between about 1.5 and about 12.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent nicotine content of the liquid nicotine formulation may be between about 1.75 and about 20, between about 1.75 and about 18, between about 1.75 and about 16, between about 1.75 and about 14 or between about 1.75 and about 12.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-miscible solvent content of the liquid nicotine formulation may be greater than or equal to about 0.06.
  • the weight percent partially water-soluble, water-immiscible solvent content of the liquid nicotine formulation may be at least about 0.06 times the weight percent water-miscible solvent content of the liquid nicotine formulation.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-miscible solvent content of the liquid nicotine formulation is greater than or equal to about 0.08.
  • the ratio of the weight percent partially water- soluble, water-immiscible solvent content to the weight percent water-miscible solvent content of the liquid nicotine formulation may be greater than or equal to about 0.1 , greater than or equal to about 0.12 or greater than or equal to about 0.14.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-miscible solvent content of the liquid nicotine formulation may be less than or equal to about 1.2.
  • the weight percent partially water-soluble, water-immiscible solvent content of the liquid nicotine formulation may be less than or equal to about 1.2 times the weight percent water- miscible solvent content of the liquid nicotine formulation.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-miscible solvent content of the liquid nicotine formulation is less than or equal to about 1.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-miscible solvent content of the liquid nicotine formulation may be less than or equal to about 0.8, less than or equal to about 0.6 or less than or equal to about 0.4.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-miscible solvent content of the liquid nicotine formulation may be between about 0.06 and about 1.2, between about 0.06 and about 1 , between about 0.06 and about 0.8, between about 0.06 and about 0.6 or between about 0.06 and about 0.4.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-miscible solvent content of the liquid nicotine formulation is between about 0.08 and about 1.2, between about 0.08 and about 1 , between about 0.08 and about 0.8, between about 0.08 and about 0.6 or between about 0.08 and about 0.4.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-miscible solvent content of the liquid nicotine formulation may be between about 0.1 and about 1.2, between about 0.1 and about 1 , between about 0.1 and about 0.8, between about 0.1 and about 0.6 or between about 0.1 and about 0.4.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-miscible solvent content of the liquid nicotine formulation may be between about 0.12 and about 1.2, between about 0.12 and about 1 , between about 0.12 and about 0.8, between about 0.1 and about 0.6 or between about 0.12 and about 0.4.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-miscible solvent content of the liquid nicotine formulation may be between about 0.14 and about 1.2, between about 0.14 and about 1 , between about 0.14 and about 0.8, between about 0.14 and about 0.6 or between about 0.14 and about 0.4.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water content of the liquid nicotine formulation may be greater than or equal to about 0.025. That is, the weight percent partially water-soluble, water-immiscible solvent content of the liquid nicotine formulation may be at least about 0.02 times the weight percent water content of the liquid nicotine formulation.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water content of the liquid nicotine formulation is greater than or equal to about 0.03.
  • the ratio of the weight percent partially water-soluble, water- immiscible solvent content to the weight percent water content of the liquid nicotine formulation may be greater than or equal to about 0.05, greater than or equal to about 0.075 or greater than or equal to about 0.1.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water content of the liquid nicotine formulation may be less than or equal to about 5.
  • the weight percent partially water-soluble, water-immiscible solvent content of the liquid nicotine formulation may be less than or equal to about 5 times the weight percent water content of the liquid nicotine formulation.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water content of the liquid nicotine formulation is less than or equal to about 1.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water content of the liquid nicotine formulation may be less than or equal to about 0.8, less than or equal to about 0.6 or less than or equal to about 0.4.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water content of the liquid nicotine formulation may be between about 0.02 and about 1.2, between about 0.02 and about 1 , between about 0.02 and about 0.8, between about 0.02 and about 0.6 or between about 0.02 and about 0.4.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water content of the liquid nicotine formulation is between about 0.03 and about 1.2, between about 0.03 and about 1 , between about 0.03 and about 0.8, between about 0.03 and about 0.6 or between about 0.03 and about 0.4.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water content of the liquid nicotine formulation may be between about 0.05 and about 1.2, between about 0.05 and about 1 , between about 0.05 and about 0.8, between about 0.05 and about 0.6 or between about 0.05 and about 0.4.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water content of the liquid nicotine formulation may be between about 0.75 and about 1.2, between about 0.75 and about 1 , between about 0.75 and about 0.8, between about 0.75 and about 0.6 or between about 0.75 and about 0.4.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water content of the liquid nicotine formulation may be between about 0.1 and about 1.2, between about 0.1 and about 1 , between about 0.1 and about 0.8, between about 0.1 and about 0.6 or between about 0.1 and about 0.4.
  • the one or more partially water-soluble, water-immiscible solvents may have a maximum carbon chain length of less than or equal to 12.
  • the one or more partially water- soluble, water-immiscible solvents may have a maximum carbon chain length of less than or equal to 10.
  • the one or more partially water-soluble, water-immiscible solvents are selected from the group consisting of polysorbate 80, triethyl citrate and triacetin.
  • the one or more partially water-soluble, water-immiscible solvents are selected from the group consisting of triethyl citrate and triacetin.
  • the liquid nicotine formulation has a water-insoluble, water-immiscible solvent content of greater than or equal to about 0.5 percent by weight. More preferably, the liquid nicotine formulation has a water-insoluble, water-immiscible solvent content of greater than or equal to about 1 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of greater than or equal to about 2 percent by weight, greater than or equal to about 3 percent by weight, greater than or equal to about 4 percent by weight or greater than or equal to about 6 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of less than or equal to about 30 percent by weight.
  • the liquid nicotine formulation has a water-insoluble, water-immiscible solvent content of less than or equal to about 25 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of less than or equal to about 20 percent by weight, less than or equal to about 15 percent by weight or less than or equal to about 10 percent by weight.
  • the liquid nicotine formulation has a water-insoluble, water-immiscible solvent content of between about 0.5 percent by weight and about 25 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of between about 0.5 percent by weight and about 20 percent by weight, between about 0.5 percent by weight and about 15 percent by weight or between about 0.5 percent by weight and about 10 percent by weight.
  • the liquid nicotine formulation has a water-insoluble, water-immiscible solvent content of between about 1 percent by weight and about 25 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of between about 1 percent by weight and about 20 percent by weight, between about 1 percent by weight and about 15 percent by weight or between about 1 percent by weight and about 10 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of between about 2 percent by weight and about 25 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of between about 2 percent by weight and about 20 percent by weight, between about 2 percent by weight and about 15 percent by weight or between about 2 percent by weight and about 10 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of between about 3 percent by weight and about 25 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of between about 3 percent by weight and about 20 percent by weight, between about 3 percent by weight and about 15 percent by weight or between about 3 percent by weight and about 10 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of between about 4 percent by weight and about 25 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of between about 4 percent by weight and about 20 percent by weight, between about 4 percent by weight and about 15 percent by weight or between about 4 percent by weight and about 10 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of between about 6 percent by weight and about 25 percent by weight.
  • the liquid nicotine formulation may have a water-insoluble, water-immiscible solvent content of between about 6 percent by weight and about 20 percent by weight, between about 6 percent by weight and about 15 percent by weight or between about 6 percent by weight and about 10 percent by weight.
  • the one or more water-insoluble, water-immiscible solvents may have a maximum carbon chain length of less than or equal to 30.
  • the one or more water-insoluble, water- immiscible solvents may have a maximum carbon chain length of less than or equal to 20, less than or equal to 18, less than or equal to 16, less than or equal to 14 or less than or equal to 12.
  • the one or more one or more water-insoluble, water-immiscible solvents are selected from the group consisting of oleic acid and MIGLYOL® (mixture of decanoyl- and octanoyl glycerides).
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-insoluble, water-immiscible solvent content of the liquid nicotine formulation may be greater than or equal to about 0.2. That is, the weight percent partially water-soluble, water-immiscible solvent content of the liquid nicotine formulation may be at least about 0.2 times the weight percent water-insoluble, water-immiscible solvent content of the liquid nicotine formulation.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-insoluble, water-immiscible solvent content of the liquid nicotine formulation is greater than or equal to about 0.4.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water- insoluble, water-immiscible solvent content of the liquid nicotine formulation may be greater than or equal to about 0.6, greater than or equal to about 0.8 or greater than or equal to about 1.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-insoluble, water-immiscible solvent content of the liquid nicotine formulation may be less than or equal to about 35.
  • the weight percent partially water-soluble, water-immiscible solvent content of the liquid nicotine formulation may be less than or equal to 35 times the weight percent water- insoluble, water-immiscible solvent content of the liquid nicotine formulation.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-insoluble, water-immiscible solvent content of the liquid nicotine formulation is less than or equal to about 30.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-insoluble, water-immiscible solvent content of the liquid nicotine formulation may be less than or equal to about 25, less than or equal to about 20 or less than or equal to about 15.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-insoluble, water-immiscible solvent content of the liquid nicotine formulation may be between about 0.2 and about 35, between about 0.2 and about 30, between about 0.2 and about 25, between about 0.2 and about 20 or between about 0.2 and about 15.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-insoluble, water-immiscible solvent content of the liquid nicotine formulation is between about 0.4 and about 35, between about 0.4 and about 30, between about 0.4 and about 25, between about 0.4 and about 20 or between about 0.4 and about 15.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-insoluble, water-immiscible solvent content of the liquid nicotine formulation may be between about 0.6 and about 35, between about 0.6 and about 30, between about 0.6 and about 25, between about 0.6 and about 20 or between about 0.6 and about 15.
  • the ratio of the weight percent partially water-soluble, water-immiscible solvent content to the weight percent water-insoluble, water-immiscible solvent content of the liquid nicotine formulation may be between about 0.8 and about 35, between about 0.8 and about 30, between about 0.8 and about 25, between about 0.8 and about 20 or between about 0.8 and about 15.
  • the liquid nicotine formulation may be a substantially uncaffeinated liquid nicotine formulation.
  • the term“substantially uncaffeinated liquid nicotine formulation” describes a liquid nicotine formulation having a caffeine content of less than 0.5 percent by weight.
  • the liquid nicotine formulation may have a caffeine content of less than about 0.4 percent by weight, less than about 0.3 percent by weight or less than about 0.2 percent by weight.
  • the liquid nicotine formulation may be a substantially caffeine-free liquid nicotine formulation.
  • substantially caffeine-free liquid nicotine formulation describes a liquid nicotine formulation having a caffeine content of less than about 0.1 percent by weight.
  • the liquid nicotine formulation may be a caffeine-free liquid nicotine formulation.
  • caffeine-free liquid nicotine formulation describes a liquid nicotine formulation having a caffeine content of 0 percent by weight.
  • caffeine describes caffeine or a caffeine salt.
  • caffeine salt the amounts of caffeine recited herein are the amount of caffeine cation.
  • the liquid nicotine formulation may comprise one or more solid emulsifiers.
  • solid emulsifier describes an emulsifier that is solid at 20°C.
  • Suitable solid emulsifiers include, but are not limited to, 1-Stearoyl- rac-glycerol, Kolliphor ® P 188, sodium caseinate, sodium dodecanoate and sodium docusate.
  • the liquid nicotine formulation has a solid emulsifier content of less than or equal to about 8 percent by weight. More preferably, the liquid nicotine formulation has a solid emulsifier content of less than or equal to about 5 percent by weight.
  • the liquid nicotine formulation comprises one or more water-soluble organic acids.
  • water-soluble organic acid describes an organic acid having a water solubility at 20°C of greater than or equal to about 500 mg/ml.
  • the one or more water-soluble organic acids may advantageously bind nicotine in the liquid nicotine formulation through formation of one or nicotine salts.
  • the one or more nicotine salts may advantageously be dissolved and stabilised in the at least one of water and one or more water-miscible solvents. This may advantageously reduce nicotine adsorption in the upper airways and enhance pulmonary nicotine delivery and retention as discussed above.
  • the liquid nicotine formulation comprises one or more water-soluble carboxylic acids.
  • Suitable water-soluble carboxylic acids include, but are not limited to, acetic acid, citric acid, lactic acid, levulinic acid, malic acid, malonic acid and pyruvic acid.
  • the liquid nicotine formulation comprises lactic acid.
  • the liquid nicotine formulation has a water-soluble organic acid content of greater than or equal to about 2 percent by weight. More preferably, the liquid nicotine formulation has a water-soluble organic acid content of greater than or equal to about 3 percent by weight.
  • the liquid nicotine formulation has a water-soluble organic acid content of less than or equal to about 8 percent by weight. More preferably, the liquid nicotine formulation has a water-soluble organic acid content of less than or equal to about 6 percent by weight.
  • the liquid nicotine formulation has a water-soluble organic acid content of between about 2 percent by weight and about 8 percent by weight.
  • the liquid nicotine formulation may have a water-soluble organic acid content of between about 2 percent by weight and about 6 percent by weight.
  • the liquid nicotine formulation has a water-soluble organic acid content of between about 3 percent by weight and about 8 percent by weight.
  • the liquid nicotine formulation may have a water-soluble organic acid content of between about 2 percent by weight and about 6 percent by weight.
  • the liquid nicotine formulation may comprise one or more flavourants.
  • Suitable flavourants include, but are not limited to, menthol.
  • the liquid nicotine formulation has a flavourant content of less than or equal to about 4 percent by weight. More preferably, the liquid nicotine formulation has a flavourant content of less than or equal to about 3 percent by weight.
  • a cartridge for use in an aerosol generating system the cartridge containing a liquid nicotine formulation according to the invention.
  • the cartridge may comprise an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • a cartridge containing the liquid nicotine formulation and an atomiser configured to generate an aerosol from the liquid nicotine formulation may be referred to as a“cartomiser”.
  • the atomiser may be a thermal atomiser.
  • thermal atomiser describes an atomiser that is configured to heat the liquid nicotine formulation to generate an aerosol.
  • the cartridge may comprise any suitable type of thermal atomiser.
  • the thermal atomiser may comprise a heater and a liquid transport element configured to transport liquid nicotine formulation to the heater.
  • the liquid transport element may comprise a capillary wick.
  • the heater may comprise a heater coil.
  • the thermal atomiser may comprise an electric heater.
  • the thermal atomiser may comprise an electric heater comprising a resistive heating element or an inductive heating element.
  • the atomiser may be a non-thermal atomiser.
  • non-thermal atomiser describes an atomiser that is configured to generate an aerosol from the liquid nicotine formulation by means other than heating.
  • the cartridge may comprise any suitable type of non-thermal atomiser.
  • the non-thermal atomiser may be an impinging jet atomiser, an ultrasonic atomiser or a vibrating mesh atomiser.
  • an aerosol-generating system comprising a liquid nicotine formulation according to the invention and an atomiser configured to generate an aerosol from the liquid nicotine formulation.
  • the atomiser may be a thermal atomiser.
  • the aerosol-generating system may comprise any suitable type of thermal atomiser.
  • the thermal atomiser may comprise a heater and a liquid transport element configured to transport liquid nicotine formulation to the heater.
  • the liquid transport element may comprise a capillary wick.
  • the heater may comprise a heater coil.
  • the thermal atomiser may comprise an electric heater.
  • the thermal atomiser may comprise an electric heater comprising a resistive heating element or an inductive heating element.
  • the atomiser may be a non-thermal atomiser.
  • the aerosol-generating system may comprise any suitable type of non-thermal atomiser.
  • the non-thermal atomiser may be an impinging jet atomiser, an ultrasonic atomiser or a vibrating mesh atomiser.
  • the aerosol-generating system may comprise: a cartridge according to the invention containing the liquid nicotine formulation; and an aerosol-generating device comprising a housing defining a device cavity configured to receive at least a portion of the cartridge.
  • the aerosol-generating system may comprise: a consumable cartridge according to the invention containing the liquid nicotine formulation; and a reusable aerosol-generating device comprising a housing defining a device cavity configured to receive at least a portion of the cartridge.
  • the aerosol-generating device may comprise a battery and control electronics.
  • the aerosol-generating system may comprise: a cartridge according to the invention containing the liquid nicotine formulation and the atomiser; and an aerosol-generating device comprising a housing defining a device cavity configured to receive at least a portion of the cartridge.
  • the aerosol-generating system may comprise: a cartridge according to the invention containing the liquid nicotine formulation; and an aerosol-generating device comprising a housing defining a device cavity configured to receive at least a portion of the cartridge and the atomiser.
  • features described above in relation to one aspect of the invention may also be applicable to other aspects of the invention.
  • features described above in relation to the liquid nicotine formulation of the invention may also relate, where appropriate, to the cartridge of the invention and the aerosol-generating system of the invention.
  • features described above in relation to the cartridge of the invention may also relate, where appropriate, to the aerosol-generating system of the invention, and vice versa.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Tobacco Products (AREA)
PCT/EP2019/087195 2018-12-31 2019-12-31 Liquid nicotine formulation comprising water-immiscible solvents Ceased WO2020141177A1 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
UAA202101822A UA128585C2 (uk) 2018-12-31 2019-12-31 Рідкий склад на основі нікотину, що містить розчинники, які не змішуються з водою
KR1020217020778A KR102930095B1 (ko) 2018-12-31 2019-12-31 수불혼화성 용매를 포함하는 액체 니코틴 제형
EP19831770.3A EP3905898B1 (en) 2018-12-31 2019-12-31 Liquid nicotine formulation comprising water-immiscible solvents
CN201980079943.9A CN113163847B (zh) 2018-12-31 2019-12-31 包含水不混溶性溶剂的液体尼古丁制剂
JP2021531580A JP2022515021A (ja) 2018-12-31 2019-12-31 水不混和性溶媒を含む液体ニコチン製剤
BR112021010222-1A BR112021010222A2 (pt) 2018-12-31 2019-12-31 Formulação de nicotina líquida compreendendo solventes imiscíveis em água
ES19831770T ES2980261T3 (es) 2018-12-31 2019-12-31 Formulación de nicotina líquida que comprende solventes inmiscibles en agua
US17/418,928 US20220053817A1 (en) 2018-12-31 2019-12-31 Liquid nicotine formulation comprising water-immiscible solvents
MX2021007623A MX427496B (es) 2018-12-31 2019-12-31 Formulacion liquida de nicotina que comprende solventes inmiscibles en agua
PL19831770.3T PL3905898T3 (pl) 2018-12-31 2019-12-31 Ciekły preparat nikotyny zawierający niemieszające się z wodą rozpuszczalniki

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
EP18215964.0 2018-12-31
EP18215983 2018-12-31
EP18215983.0 2018-12-31
EP18215969 2018-12-31
EP18215966.5 2018-12-31
EP18215964 2018-12-31
EP18215966 2018-12-31
EP18215976.4 2018-12-31
EP18215969.9 2018-12-31
EP18215976 2018-12-31

Publications (1)

Publication Number Publication Date
WO2020141177A1 true WO2020141177A1 (en) 2020-07-09

Family

ID=69104449

Family Applications (5)

Application Number Title Priority Date Filing Date
PCT/EP2019/087195 Ceased WO2020141177A1 (en) 2018-12-31 2019-12-31 Liquid nicotine formulation comprising water-immiscible solvents
PCT/EP2019/087196 Ceased WO2020141178A1 (en) 2018-12-31 2019-12-31 Liquid nicotine formulation comprising partially water-soluble solvent
PCT/EP2019/087198 Ceased WO2020141180A1 (en) 2018-12-31 2019-12-31 Liquid nicotine formulation
PCT/EP2019/087193 Ceased WO2020141176A1 (en) 2018-12-31 2019-12-31 Liquid nicotine formulation
PCT/EP2019/087202 Ceased WO2020141184A1 (en) 2018-12-31 2019-12-31 Low viscosity liquid nicotine formulation

Family Applications After (4)

Application Number Title Priority Date Filing Date
PCT/EP2019/087196 Ceased WO2020141178A1 (en) 2018-12-31 2019-12-31 Liquid nicotine formulation comprising partially water-soluble solvent
PCT/EP2019/087198 Ceased WO2020141180A1 (en) 2018-12-31 2019-12-31 Liquid nicotine formulation
PCT/EP2019/087193 Ceased WO2020141176A1 (en) 2018-12-31 2019-12-31 Liquid nicotine formulation
PCT/EP2019/087202 Ceased WO2020141184A1 (en) 2018-12-31 2019-12-31 Low viscosity liquid nicotine formulation

Country Status (11)

Country Link
US (5) US20220079210A1 (enExample)
EP (5) EP3905897A1 (enExample)
JP (6) JP2022516896A (enExample)
KR (5) KR102878504B1 (enExample)
CN (5) CN113163846B (enExample)
BR (3) BR112021010222A2 (enExample)
ES (2) ES2981302T3 (enExample)
MX (5) MX2021007626A (enExample)
PL (2) PL3905898T3 (enExample)
UA (5) UA129018C2 (enExample)
WO (5) WO2020141177A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7013754B2 (ja) * 2017-09-15 2022-02-01 株式会社三洋物産 遊技機
CN113164610A (zh) 2018-12-28 2021-07-23 菲利普莫里斯生产公司 包含低摩尔质量金属盐的液体尼古丁制剂
CN113163844B (zh) 2018-12-28 2023-08-15 菲利普莫里斯生产公司 高粘度尼古丁制剂
WO2020141177A1 (en) * 2018-12-31 2020-07-09 Philip Morris Products S.A. Liquid nicotine formulation comprising water-immiscible solvents
EP4056055A1 (en) * 2021-03-09 2022-09-14 Avogen Tech SA Device for volatilisation of an aqueous solution and method thereof
GB202110541D0 (en) * 2021-07-22 2021-09-08 Nicoventures Trading Ltd Delivery system
KR102416605B1 (ko) 2021-08-17 2022-07-05 한국과학기술원 비트라인 멀티 레벨 전압 센싱 회로
IT202100027086A1 (it) * 2021-10-21 2023-04-21 Alberto Patarchi Erogatore portatile per il trattamento o la prevenzione di un’infezione o di una patologia causata da un virus
CN113912585B (zh) * 2021-11-09 2023-02-24 深圳萨特瓦生物科技有限公司 复合尼古丁盐及其制备方法与应用、电子烟油及电子烟
CN116235996A (zh) * 2021-12-07 2023-06-09 深圳雾芯科技有限公司 电子烟液及包含其的雾化装置
KR20240012197A (ko) * 2022-07-20 2024-01-29 주식회사 케이티앤지 표면파 아토마이저에 사용하기 위한 액상형 흡입제형, 이를 포함하는 카트리지 및 에어로졸 생성장치
KR102872477B1 (ko) * 2022-08-10 2025-10-20 주식회사 케이티앤지 니코틴 흡입성 조성물 및 이를 포함하는 에어로졸 발생 장치 및 시스템
KR102885439B1 (ko) * 2022-10-07 2025-11-17 주식회사 케이티앤지 에어로졸 흡입기용 액상 조성물
CN117204598A (zh) * 2023-07-05 2023-12-12 深圳梵活生命科学股份有限公司 一种应用于雾化器可缓解烟瘾的雾化液
JP2026519054A (ja) * 2024-04-30 2026-06-11 ケーティー アンド ジー コーポレイション エアロゾル生成物品用シートおよびこれを含むエアロゾル生成物品

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104256885A (zh) * 2014-08-05 2015-01-07 云南中烟工业有限责任公司 一种电子烟烟液溶剂
US20170086500A1 (en) * 2015-09-25 2017-03-30 Altria Client Services Llc Pre-vaporization formulation for controlling acidity in an e-vaping device

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997048293A1 (fr) * 1996-06-17 1997-12-24 Japan Tobacco Inc. Parfumeur d'ambiance
WO2006004646A1 (en) * 2004-06-28 2006-01-12 Nektar Therapeutics Aerosol formulation comprising nicotine salt
JP2006109784A (ja) * 2004-10-15 2006-04-27 Mitsubishi Gas Chem Co Inc パクリタキセルの製造方法
WO2007032962A2 (en) 2005-09-09 2007-03-22 University Of Kentucky Compositions and methods for intranasal delivery of tricyclic cannabinoids
WO2007078273A1 (en) * 2005-12-22 2007-07-12 Augite Incorporation No-tar electronic smoking utensils
WO2009020666A1 (en) 2007-08-06 2009-02-12 Insys Therapeutics Inc. Oral cannabinoid liquid formulations and methods of treatment
US9314524B2 (en) * 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
US20120325228A1 (en) * 2011-06-23 2012-12-27 Williams Jonnie R Alkaloid composition for e-cigarette
DE102011114094A1 (de) * 2011-09-21 2013-03-21 F. Holzer Gmbh Stimulierendes und belebendes Nasenspray und Nasentropfen
PL2830589T3 (pl) * 2012-03-27 2019-07-31 Nicoccino Ab Preparat nikotynowy
DE102012104033B9 (de) 2012-05-08 2025-02-06 Tdk Electronics Ag Keramischer Vielschichtkondensator
US10799548B2 (en) * 2013-03-15 2020-10-13 Altria Client Services Llc Modifying taste and sensory irritation of smokeless tobacco and non-tobacco products
CA3208137A1 (en) 2013-05-06 2014-11-13 Juul Labs, Inc. Nicotine salt formulations for aerosol devices and methods thereof
WO2015006465A1 (en) 2013-07-10 2015-01-15 Ahkeo Ventures LLC Inhalable compositions comprising caffeine, methods of use and an apparatus for using the same
WO2015009862A2 (en) 2013-07-19 2015-01-22 Altria Client Services Inc. Liquid aerosol formulation of an electronic smoking article
US10265292B2 (en) * 2013-09-18 2019-04-23 The Werc Shop, LLC Terpene-based compositions, processes methodologies
AU2014323044B2 (en) 2013-09-19 2019-02-28 Philip Morris Products S.A. Aerosol-generating system for generating nicotine salt particles
WO2015042589A1 (en) * 2013-09-23 2015-03-26 Verso PV, LLC Personal vaporizer liquid for emulsifying oil-soluble compounds and resins
US9333229B2 (en) 2013-10-16 2016-05-10 William Bjorncrantz Winterized crude cannabis extracts and methods of preparation and use
US10292424B2 (en) * 2013-10-31 2019-05-21 Rai Strategic Holdings, Inc. Aerosol delivery device including a pressure-based aerosol delivery mechanism
CN103598672A (zh) * 2013-11-28 2014-02-26 刘秋明 一种电子烟烟液溶剂及电子烟烟液
CN103622161A (zh) 2013-11-28 2014-03-12 刘秋明 一种电子烟烟液溶剂及电子烟烟液
CN119606056A (zh) * 2013-12-05 2025-03-14 尤尔实验室有限公司 用于气雾剂装置的尼古丁液体制剂及其方法
WO2015117243A1 (en) 2014-02-07 2015-08-13 Bellerose Samuel Liquid formulation for e-cigarettes
US9375033B2 (en) 2014-02-14 2016-06-28 R.J. Reynolds Tobacco Company Tobacco-containing gel composition
GB201407426D0 (en) * 2014-04-28 2014-06-11 Batmark Ltd Aerosol forming component
US20150313275A1 (en) * 2014-04-30 2015-11-05 Altria Client Services, Inc. Liquid aerosol formulation of an electronic smoking article
JP6529990B2 (ja) * 2014-05-21 2019-06-12 マクニール アーベーＭｃｎｅｉｌ Ａｂ エアロゾル投与用のニコチンを含む液体製剤
KR102698762B1 (ko) * 2014-07-11 2024-08-27 필립모리스 프로덕츠 에스.에이. 공기 흐름 제어가 개선된 에어로졸 발생 시스템
JP6660370B2 (ja) * 2014-07-11 2020-03-11 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム 液体ニコチン供与源を備えるエアロゾル形成カートリッジ
GB2535427A (en) * 2014-11-07 2016-08-24 Nicoventures Holdings Ltd Solution
GB2532062A (en) * 2014-11-07 2016-05-11 Nicoventures Holdings Ltd Container
US10470090B2 (en) 2014-11-14 2019-11-05 Qualcomm Incorporated Data compression techniques for handover and radio link failure recovery
CN104473323A (zh) * 2014-12-03 2015-04-01 河南中烟工业有限责任公司 一种电子烟雾化剂
CN104585880B (zh) * 2015-01-20 2018-06-08 湖北中烟工业有限责任公司 一种用于烟用滴丸的薄荷香精溶剂
WO2016133890A1 (en) * 2015-02-19 2016-08-25 Srq Patent Holdings, Llc Compositions for e-cigarettes
CN104939305B (zh) * 2015-05-20 2016-04-20 湖南中烟工业有限责任公司 一种烟草提取物及电子烟液
US20160345621A1 (en) * 2015-06-01 2016-12-01 San Li Pre-vapor formulation of an electronic vaping device and/or methods of manufacturing the same
GB2542389A (en) * 2015-09-17 2017-03-22 Kind Consumer Ltd Simulated cigarette
CN106562469A (zh) * 2015-10-07 2017-04-19 惠州市吉瑞科技有限公司 电子烟烟液
KR102661607B1 (ko) * 2015-11-02 2024-04-30 필립모리스 프로덕츠 에스.에이. 진동 부재를 포함하는 에어로졸 발생 시스템
GB2544468A (en) * 2015-11-12 2017-05-24 Jaytee Biosciences Ltd Liquid formulation
EP3407859B1 (en) * 2016-01-29 2021-06-02 The Procter & Gamble Company Composition for enhancing hair fiber properties
US20170325494A1 (en) * 2016-05-16 2017-11-16 Lunatech, Llc Liquid composition containing nicotine from non-tobacco source for use with electronic vaporizing devices
CN109068750B (zh) * 2016-05-27 2022-12-20 菲利普莫里斯生产公司 具有液体指示剂的气溶胶生成制品
US20170348494A1 (en) * 2016-06-06 2017-12-07 Nicholas A. Havercroft Pulmonary device, method and system for delivering a pharmaceutical product to an individual
US20170367386A1 (en) 2016-06-24 2017-12-28 Allied Concessions Group, Inc. Terpene flavoring compositions
CN106036990B (zh) * 2016-08-03 2018-10-12 华健 一种复合醇电子烟雾化液
US20200345058A1 (en) * 2016-08-08 2020-11-05 Juul Labs, Inc. Nicotine Oxalic Acid Formulations
US20180084823A1 (en) * 2016-09-27 2018-03-29 BOND STREET MANUFACTURING LLC (a Florida LLC) Vaporizable Tobacco Wax Compositions and Container thereof
US20180103680A1 (en) 2016-10-18 2018-04-19 Altria Client Services Llc Methods and systems for improving stability of the pre-vapor formulation of an e-vaping device
WO2018224339A1 (en) * 2017-06-08 2018-12-13 Philip Morris Products S.A. Cartridge having a susceptor material
KR102773875B1 (ko) 2018-05-16 2025-02-27 필립모리스 프로덕츠 에스.에이. 진동 챔버를 갖는 분무기 조립체
US11919023B2 (en) 2018-05-16 2024-03-05 Philip Morris Products S.A. Atomizer and a mesh therefor
EP3574902A1 (en) * 2018-06-01 2019-12-04 Yatzz Limited Nicotine formulation and mode of delivery
GB201818711D0 (en) * 2018-11-16 2019-01-02 Nicoventures Trading Ltd Method
WO2020141177A1 (en) * 2018-12-31 2020-07-09 Philip Morris Products S.A. Liquid nicotine formulation comprising water-immiscible solvents
WO2020248071A1 (en) * 2019-06-12 2020-12-17 Lunaverse Inc. Method and system for trichome isolation

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104256885A (zh) * 2014-08-05 2015-01-07 云南中烟工业有限责任公司 一种电子烟烟液溶剂
US20170086500A1 (en) * 2015-09-25 2017-03-30 Altria Client Services Llc Pre-vaporization formulation for controlling acidity in an e-vaping device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"OECD Guidelines for the Testing of Chemicals", 2006, OECD PUBLISHING, article "Test No. 123: Partition Coefficient (1-Octanoi/Water): Slow-Stirring Method"

Also Published As

Publication number Publication date
US20220079211A1 (en) 2022-03-17
KR102901539B1 (ko) 2025-12-18
KR102930095B1 (ko) 2026-02-25
JP7590324B2 (ja) 2024-11-26
CN113163847B (zh) 2023-01-10
BR112021009726A2 (pt) 2021-08-17
KR20210108390A (ko) 2021-09-02
MX2021007625A (es) 2021-08-11
WO2020141178A1 (en) 2020-07-09
US20220071270A1 (en) 2022-03-10
JP2022516149A (ja) 2022-02-24
EP3905901A1 (en) 2021-11-10
CN113163846A (zh) 2021-07-23
JP2022516896A (ja) 2022-03-03
JP2025060944A (ja) 2025-04-10
JP2022516895A (ja) 2022-03-03
KR20210110314A (ko) 2021-09-07
EP3905898B1 (en) 2024-05-08
UA128585C2 (uk) 2024-08-21
BR112021010222A2 (pt) 2021-08-24
ES2981302T3 (es) 2024-10-08
UA129122C2 (uk) 2025-01-22
CN113163846B (zh) 2023-04-28
CN113242696B (zh) 2023-04-28
KR102878504B1 (ko) 2025-10-30
CN113163847A (zh) 2021-07-23
CN113242696A (zh) 2021-08-10
MX2021007626A (es) 2021-08-11
EP3905898A1 (en) 2021-11-10
EP3905900A1 (en) 2021-11-10
JP7863606B2 (ja) 2026-05-21
WO2020141180A1 (en) 2020-07-09
US11992038B2 (en) 2024-05-28
US20220079210A1 (en) 2022-03-17
CN113163845A (zh) 2021-07-23
EP3905900B1 (en) 2024-05-15
BR112021010614A2 (pt) 2021-08-24
KR20210109548A (ko) 2021-09-06
ES2980261T3 (es) 2024-09-30
EP3905899A1 (en) 2021-11-10
CN113163848A (zh) 2021-07-23
MX2021007624A (es) 2021-08-11
PL3905900T3 (pl) 2024-09-23
MX2021007627A (es) 2021-08-11
EP3905900C0 (en) 2024-05-15
US20220053817A1 (en) 2022-02-24
EP3905897A1 (en) 2021-11-10
KR20210108384A (ko) 2021-09-02
MX2021007623A (es) 2021-08-11
BR112021010284A2 (pt) 2021-08-17
BR112021010593A2 (pt) 2021-08-24
MX427496B (es) 2025-10-13
KR102901540B1 (ko) 2025-12-18
PL3905898T3 (pl) 2024-09-23
UA129018C2 (uk) 2024-12-25
UA129019C2 (uk) 2024-12-25
UA129123C2 (uk) 2025-01-22
EP3905898C0 (en) 2024-05-08
JP2022515021A (ja) 2022-02-17
WO2020141184A1 (en) 2020-07-09
CN113163845B (zh) 2023-04-28
JP2022515983A (ja) 2022-02-24
KR20210108394A (ko) 2021-09-02
US20220071269A1 (en) 2022-03-10
WO2020141176A1 (en) 2020-07-09
CN113163848B (zh) 2023-06-20

Similar Documents

Publication Publication Date Title
US11992038B2 (en) Liquid nicotine formulation comprising partially water-soluble solvent
RU2823145C2 (ru) Жидкая никотиновая композиция, содержащая растворители, не смешивающиеся с водой
RU2816308C2 (ru) Жидкий состав на основе никотина, содержащий частично водорастворимый растворитель
RU2829803C2 (ru) Жидкая никотиновая композиция с низкой вязкостью
BR112021010614B1 (pt) Formulações de nicotina líquida para uso em um sistema gerador de aerossol compreendendo um solvente parcialmente solúvel em água, cartucho para uso em um sistema gerador de aerossol, e sistema gerador de aerossol
BR112021009726B1 (pt) Formulação de nicotina líquida para uso em um sistema gerador de aerossol, cartucho para uso em um sistema gerador de aerossol e sistema gerador de aerossol

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19831770

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2021531580

Country of ref document: JP

Kind code of ref document: A

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112021010222

Country of ref document: BR

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2019831770

Country of ref document: EP

Effective date: 20210802

ENP Entry into the national phase

Ref document number: 112021010222

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20210526

WWG Wipo information: grant in national office

Ref document number: MX/A/2021/007623

Country of ref document: MX