MX427496B - Formulacion liquida de nicotina que comprende solventes inmiscibles en agua - Google Patents

Formulacion liquida de nicotina que comprende solventes inmiscibles en agua

Info

Publication number
MX427496B
MX427496B MX2021007623A MX2021007623A MX427496B MX 427496 B MX427496 B MX 427496B MX 2021007623 A MX2021007623 A MX 2021007623A MX 2021007623 A MX2021007623 A MX 2021007623A MX 427496 B MX427496 B MX 427496B
Authority
MX
Mexico
Prior art keywords
water
nicotine formulation
liquid nicotine
aerosol
immiscible solvents
Prior art date
Application number
MX2021007623A
Other languages
English (en)
Other versions
MX2021007623A (es
Inventor
Aline Vuarnoz-Bize
Jean-Pierre Schaller
Robert Emmett
Original Assignee
Philip Morris Products Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philip Morris Products Sa filed Critical Philip Morris Products Sa
Publication of MX2021007623A publication Critical patent/MX2021007623A/es
Publication of MX427496B publication Critical patent/MX427496B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A24B15/241—Extraction of specific substances
    • A24B15/243—Nicotine
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
    • A24B15/32—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by acyclic compounds
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/05—Devices without heating means
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/10—Devices using liquid inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/42—Cartridges or containers for inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/46—Shape or structure of electric heating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Manufacture Of Tobacco Products (AREA)

Abstract

Una formulación líquida de nicotina para su uso en un sistema generador de aerosol, la formulación líquida de nicotina comprende: al menos uno de agua y uno o más solventes miscibles en agua; uno o más solventes parcialmente solubles en agua, inmiscibles en agua que tienen una solubilidad en agua a 20 °C de entre aproximadamente 20 mg/ml y aproximadamente 100 mg/ml; y uno o más solventes insolubles en agua, inmiscibles en agua que tienen una solubilidad en agua a 20 °C menor o igual a aproximadamente 5 mg/ml, en donde la formulación líquida de nicotina tiene un contenido de solvente insoluble en agua, inmiscible en agua superior o igual a aproximadamente 2 por ciento en peso. Una formulación líquida de nicotina para su uso en un sistema generador de aerosol, la formulación líquida de nicotina comprende: al menos uno de agua y uno o más solventes miscibles en agua; uno o más solventes parcialmente solubles en agua, inmiscibles en agua que tienen un coeficiente de partición (log P) a 20 °C de entre aproximadamente 0.05 y aproximadamente 0.5; y uno o más solventes insolubles en agua, inmiscibles en agua que tienen un coeficiente de partición (log P) a 20 °C superior a aproximadamente 5, en donde la formulación líquida de nicotina tiene un contenido de solvente insoluble en agua, inmiscible en agua superior o igual a aproximadamente 2 por ciento en peso. Un cartucho para su uso en un sistema generador de aerosol, el cartucho contiene la formulación líquida de nicotina. Un sistema generador de aerosol que comprende la formulación líquida de nicotina y un atomizador configurado para generar un aerosol a partir de la formulación líquida de nicotina.
MX2021007623A 2018-12-31 2019-12-31 Formulacion liquida de nicotina que comprende solventes inmiscibles en agua MX427496B (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP18215983 2018-12-31
EP18215969 2018-12-31
EP18215964 2018-12-31
EP18215966 2018-12-31
EP18215976 2018-12-31
PCT/EP2019/087195 WO2020141177A1 (en) 2018-12-31 2019-12-31 Liquid nicotine formulation comprising water-immiscible solvents

Publications (2)

Publication Number Publication Date
MX2021007623A MX2021007623A (es) 2021-08-11
MX427496B true MX427496B (es) 2025-10-13

Family

ID=69104449

Family Applications (5)

Application Number Title Priority Date Filing Date
MX2021007626A MX2021007626A (es) 2018-12-31 2019-12-31 Formulacion de nicotina liquida de baja viscosidad.
MX2021007627A MX2021007627A (es) 2018-12-31 2019-12-31 Formulacion de nicotina liquida.
MX2021007625A MX2021007625A (es) 2018-12-31 2019-12-31 Formulacion de nicotina liquida que comprende un solvente parcialmente soluble en agua.
MX2021007624A MX2021007624A (es) 2018-12-31 2019-12-31 Formulacion de nicotina liquida.
MX2021007623A MX427496B (es) 2018-12-31 2019-12-31 Formulacion liquida de nicotina que comprende solventes inmiscibles en agua

Family Applications Before (4)

Application Number Title Priority Date Filing Date
MX2021007626A MX2021007626A (es) 2018-12-31 2019-12-31 Formulacion de nicotina liquida de baja viscosidad.
MX2021007627A MX2021007627A (es) 2018-12-31 2019-12-31 Formulacion de nicotina liquida.
MX2021007625A MX2021007625A (es) 2018-12-31 2019-12-31 Formulacion de nicotina liquida que comprende un solvente parcialmente soluble en agua.
MX2021007624A MX2021007624A (es) 2018-12-31 2019-12-31 Formulacion de nicotina liquida.

Country Status (11)

Country Link
US (5) US20220079210A1 (es)
EP (5) EP3905897A1 (es)
JP (6) JP2022516896A (es)
KR (5) KR102878504B1 (es)
CN (5) CN113163846B (es)
BR (3) BR112021010222A2 (es)
ES (2) ES2981302T3 (es)
MX (5) MX2021007626A (es)
PL (2) PL3905898T3 (es)
UA (5) UA129018C2 (es)
WO (5) WO2020141177A1 (es)

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Also Published As

Publication number Publication date
US20220079211A1 (en) 2022-03-17
WO2020141177A1 (en) 2020-07-09
KR102901539B1 (ko) 2025-12-18
KR102930095B1 (ko) 2026-02-25
JP7590324B2 (ja) 2024-11-26
CN113163847B (zh) 2023-01-10
BR112021009726A2 (pt) 2021-08-17
KR20210108390A (ko) 2021-09-02
MX2021007625A (es) 2021-08-11
WO2020141178A1 (en) 2020-07-09
US20220071270A1 (en) 2022-03-10
JP2022516149A (ja) 2022-02-24
EP3905901A1 (en) 2021-11-10
CN113163846A (zh) 2021-07-23
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